TCHP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)5.26037721
2axonemal dynein complex assembly (GO:0070286)4.90110688
3positive regulation of gamma-delta T cell activation (GO:0046645)4.60978898
4regulation of cytokine production involved in inflammatory response (GO:1900015)4.32518843
5interkinetic nuclear migration (GO:0022027)4.17399680
6motile cilium assembly (GO:0044458)4.13455806
7piRNA metabolic process (GO:0034587)4.10521089
8negative regulation of T cell mediated immunity (GO:0002710)4.02448184
9microtubule depolymerization (GO:0007019)4.01523805
10histone H3-K4 trimethylation (GO:0080182)3.96047402
11positive regulation of B cell differentiation (GO:0045579)3.81472281
12positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.79826722
13cilium movement (GO:0003341)3.73990242
14epithelial cilium movement (GO:0003351)3.68311171
15regulation of DNA endoreduplication (GO:0032875)3.65585274
16DNA methylation involved in gamete generation (GO:0043046)3.63928149
17negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.59987399
18negative regulation of cell killing (GO:0031342)3.59987399
19response to interleukin-15 (GO:0070672)3.57588471
20centriole assembly (GO:0098534)3.50215275
21regulation of RIG-I signaling pathway (GO:0039535)3.50058026
22positive regulation of granulocyte differentiation (GO:0030854)3.49926035
23DNA deamination (GO:0045006)3.47910470
24cellular response to interleukin-15 (GO:0071350)3.43263504
25acrosome reaction (GO:0007340)3.43012406
26mast cell activation involved in immune response (GO:0002279)3.40915761
27mast cell degranulation (GO:0043303)3.40915761
28epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.38735479
29L-fucose catabolic process (GO:0042355)3.37784931
30fucose catabolic process (GO:0019317)3.37784931
31L-fucose metabolic process (GO:0042354)3.37784931
32regulation of gamma-delta T cell differentiation (GO:0045586)3.37506865
33negative regulation of lymphocyte mediated immunity (GO:0002707)3.30966409
34male meiosis (GO:0007140)3.30490215
35multicellular organism reproduction (GO:0032504)3.30397070
36negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.21431835
37regulation of B cell receptor signaling pathway (GO:0050855)3.21168210
38centriole replication (GO:0007099)3.18921763
39sperm motility (GO:0030317)3.16583784
40positive regulation of defense response to virus by host (GO:0002230)3.16457038
41adenosine metabolic process (GO:0046085)3.12604231
42regulation of gamma-delta T cell activation (GO:0046643)3.10854969
43B cell receptor signaling pathway (GO:0050853)3.10469267
44nerve growth factor signaling pathway (GO:0038180)3.08662387
45opioid receptor signaling pathway (GO:0038003)3.04302060
46regulation of B cell differentiation (GO:0045577)3.02361825
47ventricular system development (GO:0021591)3.02299105
48axoneme assembly (GO:0035082)2.98311167
49regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.97920713
50fusion of sperm to egg plasma membrane (GO:0007342)2.95279856
51mast cell activation (GO:0045576)2.89464844
52histone H3-K9 methylation (GO:0051567)2.87687714
53regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.81114021
54positive regulation of erythrocyte differentiation (GO:0045648)2.80894616
55tyrosine phosphorylation of STAT protein (GO:0007260)2.80564706
56purinergic nucleotide receptor signaling pathway (GO:0035590)2.78653482
57tolerance induction (GO:0002507)2.75727888
58histone H2B ubiquitination (GO:0033523)2.74415865
59alpha-beta T cell differentiation (GO:0046632)2.73435558
60mRNA cleavage (GO:0006379)2.72870985
61positive regulation of interleukin-1 beta secretion (GO:0050718)2.72804447
62regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.70816902
63V(D)J recombination (GO:0033151)2.69922470
64microtubule polymerization or depolymerization (GO:0031109)2.69301843
65regulation of female gonad development (GO:2000194)2.69068645
66photoreceptor cell maintenance (GO:0045494)2.69019982
67male meiosis I (GO:0007141)2.68826768
68regulation of timing of cell differentiation (GO:0048505)2.67774419
69regulation of memory T cell differentiation (GO:0043380)2.67522223
70pseudouridine synthesis (GO:0001522)2.66823422
71ribosomal large subunit biogenesis (GO:0042273)2.66351252
72regulation of interleukin-6 biosynthetic process (GO:0045408)2.65063218
73negative regulation of translation, ncRNA-mediated (GO:0040033)2.64538924
74regulation of translation, ncRNA-mediated (GO:0045974)2.64538924
75negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.64538924
76leukocyte aggregation (GO:0070486)2.64108355
77positive regulation of T cell mediated cytotoxicity (GO:0001916)2.61766696
78regulation of cilium movement (GO:0003352)2.61592502
79viral transcription (GO:0019083)2.61573266
80face development (GO:0060324)2.61340446
81mesenchymal cell differentiation involved in renal system development (GO:2001012)2.60485522
82mesenchymal cell differentiation involved in kidney development (GO:0072161)2.60485522
83histone H3-K4 methylation (GO:0051568)2.59673460
84acrosome assembly (GO:0001675)2.58160284
85poly(A)+ mRNA export from nucleus (GO:0016973)2.57529645
86spinal cord motor neuron differentiation (GO:0021522)2.56388036
87head development (GO:0060322)2.55955707
88histone H3-K9 modification (GO:0061647)2.55832650
89negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.55513274
90retina layer formation (GO:0010842)2.55511059
91alpha-beta T cell activation (GO:0046631)2.55074947
92negative regulation of cAMP-mediated signaling (GO:0043951)2.54569598
93mitochondrial RNA metabolic process (GO:0000959)2.53868108
94regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.53004080
95nonmotile primary cilium assembly (GO:0035058)2.51722413
96peptidyl-lysine trimethylation (GO:0018023)2.51431569
97cerebral cortex radially oriented cell migration (GO:0021799)2.50702126
98translational termination (GO:0006415)2.50691601
99negative regulation of execution phase of apoptosis (GO:1900118)2.49674016
100positive regulation of interleukin-1 secretion (GO:0050716)2.49585212
101limb bud formation (GO:0060174)2.49557740
102positive regulation of T cell differentiation in thymus (GO:0033089)2.49316947
103left/right axis specification (GO:0070986)2.49245238
104regulation of T cell mediated cytotoxicity (GO:0001914)2.48853242
105cilium organization (GO:0044782)2.48727149
106cell proliferation in forebrain (GO:0021846)2.48708395
107positive T cell selection (GO:0043368)2.48555892
108cilium assembly (GO:0042384)2.48390733
109defense response to protozoan (GO:0042832)2.47977900
110positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)2.47344589
111regulation of interleukin-12 biosynthetic process (GO:0045075)2.46133967
112regulation of granulocyte differentiation (GO:0030852)2.45731810
113protein K48-linked deubiquitination (GO:0071108)2.45413819
114positive regulation of cell killing (GO:0031343)2.44849283
115regulation of defense response to virus by host (GO:0050691)2.42680715
116spermatid development (GO:0007286)2.41867436
117positive thymic T cell selection (GO:0045059)2.41139369
118histone-serine phosphorylation (GO:0035404)2.40425930
119natural killer cell differentiation (GO:0001779)2.40352701
120regulation of erythrocyte differentiation (GO:0045646)2.39709873
121ketone body metabolic process (GO:1902224)2.39698404
122cellular ketone body metabolic process (GO:0046950)2.39561003
123leukocyte degranulation (GO:0043299)2.38505022
124positive regulation of interleukin-1 beta production (GO:0032731)2.38331655
125negative regulation of leukocyte mediated immunity (GO:0002704)2.38011048
126cellular response to gamma radiation (GO:0071480)2.37912712
127positive regulation of protein kinase C signaling (GO:0090037)2.37494013
128positive regulation of protein deacetylation (GO:0090312)2.37203383
129gonadal mesoderm development (GO:0007506)2.36503532
130DNA methylation (GO:0006306)2.35810718
131DNA alkylation (GO:0006305)2.35810718
132regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.35409014
133positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.35407321
134mitochondrial respiratory chain complex I assembly (GO:0032981)2.35115363
135NADH dehydrogenase complex assembly (GO:0010257)2.35115363
136mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.35115363
137positive regulation of DNA recombination (GO:0045911)2.35030410
138meiotic cell cycle (GO:0051321)2.34812904
139centrosome localization (GO:0051642)2.34806815
140axon ensheathment in central nervous system (GO:0032291)2.34792583
141central nervous system myelination (GO:0022010)2.34792583
142pyrimidine ribonucleoside catabolic process (GO:0046133)2.34290753
143female gonad development (GO:0008585)2.33968619
144detection of light stimulus involved in visual perception (GO:0050908)2.33301324
145detection of light stimulus involved in sensory perception (GO:0050962)2.33301324
146preassembly of GPI anchor in ER membrane (GO:0016254)2.32629347
147regulation of development, heterochronic (GO:0040034)2.32626880
148G-protein coupled receptor internalization (GO:0002031)2.32476323
149reproduction (GO:0000003)2.32052820
150protein polyglutamylation (GO:0018095)2.31979744
151positive regulation of meiosis (GO:0045836)2.30451170
152regulation of rhodopsin mediated signaling pathway (GO:0022400)2.30259742
153regulation of meiosis I (GO:0060631)2.29881794
154sperm-egg recognition (GO:0035036)2.29763783
155intraciliary transport (GO:0042073)2.27893384
156single fertilization (GO:0007338)2.26694272
157positive regulation of meiotic cell cycle (GO:0051446)2.26394508
158DNA ligation (GO:0006266)2.25294445
159cranial nerve morphogenesis (GO:0021602)2.25293544
160lateral sprouting from an epithelium (GO:0060601)2.24373551
161startle response (GO:0001964)2.24025484
162rhodopsin mediated signaling pathway (GO:0016056)2.23106757
163regulation of spindle checkpoint (GO:0090231)2.22973285
164superoxide anion generation (GO:0042554)2.22709458
165protein localization to cilium (GO:0061512)2.22224601
166modulation by virus of host process (GO:0019054)2.20707085
167negative regulation of myoblast differentiation (GO:0045662)2.20240588
168response to X-ray (GO:0010165)2.18551579
169cell differentiation in spinal cord (GO:0021515)2.18305857
170maintenance of protein location in nucleus (GO:0051457)2.16721023
171GPI anchor biosynthetic process (GO:0006506)2.15459046
172inner ear receptor stereocilium organization (GO:0060122)2.13326619
173DNA integration (GO:0015074)2.13262230
174synapsis (GO:0007129)2.13224135
175DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.12841184
176synaptonemal complex organization (GO:0070193)2.10221519
177activated T cell proliferation (GO:0050798)2.09966292
178mRNA splice site selection (GO:0006376)2.09648102
179negative regulation of keratinocyte proliferation (GO:0010839)2.09558353
180histone H3-K36 demethylation (GO:0070544)2.09284970
181DNA damage response, signal transduction resulting in transcription (GO:0042772)2.07579451
182DNA strand renaturation (GO:0000733)2.07256867
183negative regulation of appetite (GO:0032099)2.06697875
184negative regulation of response to food (GO:0032096)2.06697875
185cellular component assembly involved in morphogenesis (GO:0010927)2.06250944

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.22606207
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.55374995
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.22469574
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.05375465
5EZH2_22144423_ChIP-Seq_EOC_Human2.93033028
6ELF1_17652178_ChIP-ChIP_JURKAT_Human2.86028553
7PCGF2_27294783_Chip-Seq_ESCs_Mouse2.73852545
8SCL_19346495_ChIP-Seq_HPC-7_Human2.68420682
9GBX2_23144817_ChIP-Seq_PC3_Human2.64568523
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.63657346
11CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.63420186
12PCGF2_27294783_Chip-Seq_NPCs_Mouse2.53865632
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.43447078
14TP63_19390658_ChIP-ChIP_HaCaT_Human2.42433665
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.37918942
16SUZ12_27294783_Chip-Seq_NPCs_Mouse2.28376449
17BMI1_23680149_ChIP-Seq_NPCS_Mouse2.21899354
18NFE2_27457419_Chip-Seq_LIVER_Mouse2.21482036
19CBX2_27304074_Chip-Seq_ESCs_Mouse2.21127568
20RUNX_20019798_ChIP-Seq_JUKART_Human2.18209586
21IGF1R_20145208_ChIP-Seq_DFB_Human2.15142576
22VDR_22108803_ChIP-Seq_LS180_Human2.11819668
23FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.07598657
24BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.05505899
25RNF2_27304074_Chip-Seq_NSC_Mouse2.00681771
26EST1_17652178_ChIP-ChIP_JURKAT_Human1.99860561
27ZNF274_21170338_ChIP-Seq_K562_Hela1.98808671
28IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.93820557
29PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.91801372
30GABP_17652178_ChIP-ChIP_JURKAT_Human1.91116309
31IRF8_21731497_ChIP-ChIP_J774_Mouse1.90669918
32IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.90083322
33* SPI1_23547873_ChIP-Seq_NB4_Human1.88964460
34TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.87405853
35MYB_26560356_Chip-Seq_TH2_Human1.86274421
36NANOG_18555785_Chip-Seq_ESCs_Mouse1.83685403
37VDR_23849224_ChIP-Seq_CD4+_Human1.82068325
38NOTCH1_21737748_ChIP-Seq_TLL_Human1.77722237
39MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.74183197
40VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.73807558
41EZH2_27294783_Chip-Seq_NPCs_Mouse1.71984170
42E2F1_18555785_Chip-Seq_ESCs_Mouse1.70188357
43SUZ12_18555785_Chip-Seq_ESCs_Mouse1.70078187
44STAT3_18555785_Chip-Seq_ESCs_Mouse1.69099177
45EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.68493890
46GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.66648149
47TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.61855912
48POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.61855912
49EZH2_27304074_Chip-Seq_ESCs_Mouse1.60670788
50MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.60512652
51CMYC_18555785_Chip-Seq_ESCs_Mouse1.59557203
52POU3F2_20337985_ChIP-ChIP_501MEL_Human1.58298200
53GATA3_26560356_Chip-Seq_TH2_Human1.57211624
54JARID2_20064375_ChIP-Seq_MESCs_Mouse1.56058579
55NMYC_18555785_Chip-Seq_ESCs_Mouse1.56054069
56P53_22387025_ChIP-Seq_ESCs_Mouse1.55791148
57EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.55468941
58SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.55008415
59CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.54461879
60OCT4_18555785_Chip-Seq_ESCs_Mouse1.54343068
61SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.52681480
62P300_18555785_Chip-Seq_ESCs_Mouse1.51616966
63MYB_26560356_Chip-Seq_TH1_Human1.51438051
64E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.51211652
65KLF4_18555785_Chip-Seq_ESCs_Mouse1.45418429
66POU5F1_16153702_ChIP-ChIP_HESCs_Human1.45202004
67ZFX_18555785_Chip-Seq_ESCs_Mouse1.44447807
68RUNX1_27457419_Chip-Seq_LIVER_Mouse1.44446232
69TAF15_26573619_Chip-Seq_HEK293_Human1.43833285
70VDR_21846776_ChIP-Seq_THP-1_Human1.43324840
71ER_23166858_ChIP-Seq_MCF-7_Human1.41863995
72SOX2_18555785_Chip-Seq_ESCs_Mouse1.41596666
73RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.39926286
74CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.38827140
75IRF1_19129219_ChIP-ChIP_H3396_Human1.37331843
76ESRRB_18555785_Chip-Seq_ESCs_Mouse1.36759913
77GATA3_27048872_Chip-Seq_THYMUS_Human1.35936589
78RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.35916129
79PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.35784384
80SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.35579974
81CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35500249
82E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.35422662
83* E2F4_17652178_ChIP-ChIP_JURKAT_Human1.35121003
84PU1_27457419_Chip-Seq_LIVER_Mouse1.33968558
85MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.33296370
86FUS_26573619_Chip-Seq_HEK293_Human1.33238241
87SPI1_23127762_ChIP-Seq_K562_Human1.32656576
88* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.32586015
89* FOXP3_21729870_ChIP-Seq_TREG_Human1.31875204
90FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.31757934
91EED_16625203_ChIP-ChIP_MESCs_Mouse1.31459304
92P300_19829295_ChIP-Seq_ESCs_Human1.31312860
93IKZF1_21737484_ChIP-ChIP_HCT116_Human1.30154902
94FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.30109380
95CTBP1_25329375_ChIP-Seq_LNCAP_Human1.30098983
96MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.29431499
97DROSHA_22980978_ChIP-Seq_HELA_Human1.29045101
98TAL1_26923725_Chip-Seq_HPCs_Mouse1.28916776
99CIITA_25753668_ChIP-Seq_RAJI_Human1.28660110
100RNF2_27304074_Chip-Seq_ESCs_Mouse1.27515287
101LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27125919
102* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.26925964
103CTCF_18555785_Chip-Seq_ESCs_Mouse1.26792157
104GATA1_26923725_Chip-Seq_HPCs_Mouse1.26702783
105SMAD1_18555785_Chip-Seq_ESCs_Mouse1.26404065
106OCT4_21477851_ChIP-Seq_ESCs_Mouse1.25413050
107VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.25269962
108CTBP2_25329375_ChIP-Seq_LNCAP_Human1.24868125
109RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23140998
110CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.22580731
111ETS1_20019798_ChIP-Seq_JURKAT_Human1.20295798
112MYC_18940864_ChIP-ChIP_HL60_Human1.20151294
113SMAD4_21799915_ChIP-Seq_A2780_Human1.19978195
114EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.19914638
115MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.18932980
116CRX_20693478_ChIP-Seq_RETINA_Mouse1.17908926
117VDR_24763502_ChIP-Seq_THP-1_Human1.17393174
118LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.17067854
119EZH2_27294783_Chip-Seq_ESCs_Mouse1.16922140
120UTX_26944678_Chip-Seq_JUKART_Human1.16824713
121SMAD3_21741376_ChIP-Seq_EPCs_Human1.16610943
122MAF_26560356_Chip-Seq_TH1_Human1.16462575
123FOXM1_23109430_ChIP-Seq_U2OS_Human1.16369994
124GATA2_22383799_ChIP-Seq_G1ME_Mouse1.15531645
125TCF4_23295773_ChIP-Seq_U87_Human1.15344765
126EWS_26573619_Chip-Seq_HEK293_Human1.14551433
127PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.13918937
128SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.13574438
129SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.11955095
130TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.11719410
131CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.10737046
132KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.09990131
133P300_27268052_Chip-Seq_Bcells_Human1.09559797
134TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09088538
135ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.08937446
136MYC_22102868_ChIP-Seq_BL_Human1.08624713
137MAF_26560356_Chip-Seq_TH2_Human1.08620885
138BP1_19119308_ChIP-ChIP_Hs578T_Human1.08574241
139EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.08084672
140* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.06085538
141P53_21459846_ChIP-Seq_SAOS-2_Human1.05854307
142SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.04736374
143PRDM14_20953172_ChIP-Seq_ESCs_Human1.04532223
144CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.04069373
145BCL6_27268052_Chip-Seq_Bcells_Human1.03140367
146FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.03008806
147KDM2B_26808549_Chip-Seq_REH_Human1.02124164
148HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.01530957
149GF1_26923725_Chip-Seq_HPCs_Mouse1.01438638
150STAT6_21828071_ChIP-Seq_BEAS2B_Human1.01271962
151MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00885924
152TBL1_22424771_ChIP-Seq_293T_Human1.00475398
153SUZ12_27294783_Chip-Seq_ESCs_Mouse1.00439362
154SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.99798168
155NCOR_22424771_ChIP-Seq_293T_Human0.99556305
156RUNX2_22187159_ChIP-Seq_PCA_Human0.99137120
157KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.99019676
158* STAT3_23295773_ChIP-Seq_U87_Human0.98196591
159BCAT_22108803_ChIP-Seq_LS180_Human0.98113249
160JARID2_20075857_ChIP-Seq_MESCs_Mouse0.97535852
161GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.96380005
162ERG_20517297_ChIP-Seq_VCAP_Human0.95864555
163WDR5_24793694_ChIP-Seq_LNCAP_Human0.95612361
164FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.95412172
165P53_22127205_ChIP-Seq_FIBROBLAST_Human0.95263291
166IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.94072367
167CBP_20019798_ChIP-Seq_JUKART_Human0.94072367
168* SMRT_27268052_Chip-Seq_Bcells_Human0.94062771
169ELK1_19687146_ChIP-ChIP_HELA_Human0.93460250
170AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.92805759
171CEBPB_22108803_ChIP-Seq_LS180_Human0.92422896
172GATA3_21878914_ChIP-Seq_MCF-7_Human0.91758793
173GATA3_26560356_Chip-Seq_TH1_Human0.90151620
174RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.89429480
175E2F1_20622854_ChIP-Seq_HELA_Human0.89044383
176TDRD3_21172665_ChIP-Seq_MCF-7_Human0.88715716
177PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88336007
178MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.87094791
179FOXA1_21572438_ChIP-Seq_LNCaP_Human0.86032600
180TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.85155717
181RUNX1_22412390_ChIP-Seq_EML_Mouse0.84683943
182* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.84542937
183* NANOG_20526341_ChIP-Seq_ESCs_Human0.84415547

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis3.98134030
2MP0006292_abnormal_olfactory_placode3.60575226
3MP0003136_yellow_coat_color3.36210368
4MP0005410_abnormal_fertilization3.13006182
5MP0003806_abnormal_nucleotide_metabolis2.67337780
6MP0008877_abnormal_DNA_methylation2.60495642
7MP0002102_abnormal_ear_morphology2.58517345
8MP0001873_stomach_inflammation2.51077514
9MP0003787_abnormal_imprinting2.51075973
10MP0000685_abnormal_immune_system2.40950377
11MP0008057_abnormal_DNA_replication2.36515365
12MP0002163_abnormal_gland_morphology2.23014937
13MP0001800_abnormal_humoral_immune2.20582579
14MP0001986_abnormal_taste_sensitivity2.20063737
15MP0003724_increased_susceptibility_to2.13011364
16MP0004381_abnormal_hair_follicle2.11682671
17MP0002138_abnormal_hepatobiliary_system2.11508122
18MP0002396_abnormal_hematopoietic_system2.10571454
19MP0000372_irregular_coat_pigmentation2.09634471
20MP0002277_abnormal_respiratory_mucosa2.08285593
21MP0003828_pulmonary_edema2.06040020
22MP0001188_hyperpigmentation2.03551193
23MP0005423_abnormal_somatic_nervous1.90954881
24MP0005257_abnormal_intraocular_pressure1.89859140
25MP0008058_abnormal_DNA_repair1.89858794
26MP0002405_respiratory_system_inflammati1.88240645
27MP0004742_abnormal_vestibular_system1.86368502
28MP0002095_abnormal_skin_pigmentation1.85004228
29MP0005409_darkened_coat_color1.79426631
30MP0005551_abnormal_eye_electrophysiolog1.78422841
31MP0003941_abnormal_skin_development1.75919677
32MP0005379_endocrine/exocrine_gland_phen1.73273163
33MP0002420_abnormal_adaptive_immunity1.66720388
34MP0005171_absent_coat_pigmentation1.66437521
35MP0008995_early_reproductive_senescence1.64328017
36MP0000703_abnormal_thymus_morphology1.64114986
37MP0001819_abnormal_immune_cell1.62328858
38MP0003698_abnormal_male_reproductive1.61448606
39MP0005645_abnormal_hypothalamus_physiol1.58929101
40MP0002723_abnormal_immune_serum1.57361554
41MP0008007_abnormal_cellular_replicative1.57138076
42MP0009379_abnormal_foot_pigmentation1.56263419
43MP0002398_abnormal_bone_marrow1.55426480
44MP0006072_abnormal_retinal_apoptosis1.55210974
45MP0005253_abnormal_eye_physiology1.52582286
46MP0003183_abnormal_peptide_metabolism1.51307879
47MP0002722_abnormal_immune_system1.49187055
48MP0001346_abnormal_lacrimal_gland1.47553990
49MP0002452_abnormal_antigen_presenting1.47177307
50MP0000689_abnormal_spleen_morphology1.44446032
51MP0005000_abnormal_immune_tolerance1.42677602
52MP0005646_abnormal_pituitary_gland1.42144062
53MP0002938_white_spotting1.41087173
54MP0002210_abnormal_sex_determination1.39932522
55MP0002249_abnormal_larynx_morphology1.39080525
56MP0003938_abnormal_ear_development1.38183146
57MP0000383_abnormal_hair_follicle1.37566991
58MP0003693_abnormal_embryo_hatching1.37136785
59MP0000716_abnormal_immune_system1.36824817
60MP0001929_abnormal_gametogenesis1.36618670
61MP0001486_abnormal_startle_reflex1.33548143
62MP0000049_abnormal_middle_ear1.31138546
63MP0005499_abnormal_olfactory_system1.30093035
64MP0005394_taste/olfaction_phenotype1.30093035
65MP0003436_decreased_susceptibility_to1.26117313
66MP0005025_abnormal_response_to1.24022821
67MP0006276_abnormal_autonomic_nervous1.23054948
68MP0008789_abnormal_olfactory_epithelium1.21425004
69MP0001968_abnormal_touch/_nociception1.20206965
70MP0003950_abnormal_plasma_membrane1.19832031
71MP0002928_abnormal_bile_duct1.19521521
72MP0000026_abnormal_inner_ear1.19470621
73MP0000631_abnormal_neuroendocrine_gland1.19138391
74MP0004808_abnormal_hematopoietic_stem1.18080416
75MP0004147_increased_porphyrin_level1.18032432
76MP0003111_abnormal_nucleus_morphology1.17888364
77MP0002419_abnormal_innate_immunity1.16911644
78MP0002132_abnormal_respiratory_system1.11684233
79MP0003937_abnormal_limbs/digits/tail_de1.10807500
80MP0003880_abnormal_central_pattern1.09760665
81MP0005174_abnormal_tail_pigmentation1.09162156
82MP0000569_abnormal_digit_pigmentation1.08888429
83MP0004043_abnormal_pH_regulation1.07405454
84MP0005391_vision/eye_phenotype1.06123579
85MP0000015_abnormal_ear_pigmentation1.06097709
86MP0002429_abnormal_blood_cell1.05748481
87MP0000778_abnormal_nervous_system1.05695844
88MP0003121_genomic_imprinting1.05353335
89MP0009046_muscle_twitch1.04796076
90MP0003011_delayed_dark_adaptation1.03020052
91MP0010094_abnormal_chromosome_stability1.02274997
92MP0001145_abnormal_male_reproductive1.01356659
93MP0001663_abnormal_digestive_system0.99542581
94MP0003943_abnormal_hepatobiliary_system0.98740661
95MP0005075_abnormal_melanosome_morpholog0.98179387
96MP0003077_abnormal_cell_cycle0.97166705
97MP0001485_abnormal_pinna_reflex0.96406916
98MP0009250_abnormal_appendicular_skeleto0.96120376
99MP0001963_abnormal_hearing_physiology0.96087553
100MP0005451_abnormal_body_composition0.95636225
101MP0005671_abnormal_response_to0.95195657
102MP0002638_abnormal_pupillary_reflex0.95072512
103MP0000427_abnormal_hair_cycle0.93865277
104MP0002752_abnormal_somatic_nervous0.93716633
105MP0005623_abnormal_meninges_morphology0.91515735
106MP0001984_abnormal_olfaction0.90030482
107MP0003786_premature_aging0.89692797
108MP0000653_abnormal_sex_gland0.89114532
109MP0000432_abnormal_head_morphology0.88516809
110MP0002233_abnormal_nose_morphology0.88330285
111MP0003045_fibrosis0.88035941
112MP0005387_immune_system_phenotype0.88007142
113MP0001790_abnormal_immune_system0.88007142
114MP0002876_abnormal_thyroid_physiology0.87361414
115MP0005195_abnormal_posterior_eye0.87084129
116MP0002098_abnormal_vibrissa_morphology0.86861334
117MP0004142_abnormal_muscle_tone0.86821931
118MP0008260_abnormal_autophagy0.86719408
119MP0002116_abnormal_craniofacial_bone0.85719570
120MP0005310_abnormal_salivary_gland0.85679296
121MP0000579_abnormal_nail_morphology0.85247666
122MP0005266_abnormal_metabolism0.85048198
123MP0001286_abnormal_eye_development0.84380628
124MP0003878_abnormal_ear_physiology0.83717719
125MP0005377_hearing/vestibular/ear_phenot0.83717719
126MP0001293_anophthalmia0.82563742
127MP0002697_abnormal_eye_size0.81909905
128MP0002009_preneoplasia0.81459046
129MP0002177_abnormal_outer_ear0.80803230
130MP0003385_abnormal_body_wall0.80134234
131MP0001835_abnormal_antigen_presentation0.79979018
132MP0002148_abnormal_hypersensitivity_rea0.79948706
133MP0006036_abnormal_mitochondrial_physio0.79267849
134MP0003755_abnormal_palate_morphology0.79143136
135MP0003763_abnormal_thymus_physiology0.77340546
136MP0000465_gastrointestinal_hemorrhage0.77241740
137MP0009333_abnormal_splenocyte_physiolog0.77108356
138MP0003303_peritoneal_inflammation0.76740092
139MP0003890_abnormal_embryonic-extraembry0.76290805
140MP0009785_altered_susceptibility_to0.76205846
141MP0003172_abnormal_lysosome_physiology0.76005087
142MP0000762_abnormal_tongue_morphology0.74962998
143MP0005083_abnormal_biliary_tract0.74534679
144MP0001851_eye_inflammation0.73259206
145MP0002127_abnormal_cardiovascular_syste0.73119043
146MP0002161_abnormal_fertility/fecundity0.72500894
147MP0003866_abnormal_defecation0.72284438
148MP0002735_abnormal_chemical_nociception0.71920342
149MP0000613_abnormal_salivary_gland0.70176039
150MP0001765_abnormal_ion_homeostasis0.69623303
151MP0000678_abnormal_parathyroid_gland0.69017177
152MP0005389_reproductive_system_phenotype0.68979249
153MP0002736_abnormal_nociception_after0.68612099
154MP0003315_abnormal_perineum_morphology0.68521071
155MP0001324_abnormal_eye_pigmentation0.67189772
156MP0005360_urolithiasis0.65806142
157MP0002019_abnormal_tumor_incidence0.65505793
158MP0002160_abnormal_reproductive_system0.65317898
159MP0003122_maternal_imprinting0.64206083
160MP0001545_abnormal_hematopoietic_system0.64009753
161MP0005397_hematopoietic_system_phenotyp0.64009753
162MP0001502_abnormal_circadian_rhythm0.63959984
163MP0009745_abnormal_behavioral_response0.63174050
164MP0001905_abnormal_dopamine_level0.61485314
165MP0001853_heart_inflammation0.61143487

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.79467903
2Absent/shortened dynein arms (HP:0200106)5.36298064
3Dynein arm defect of respiratory motile cilia (HP:0012255)5.36298064
4Abnormal respiratory motile cilium physiology (HP:0012261)4.40301798
5Chromosomal breakage induced by crosslinking agents (HP:0003221)4.24809600
6Abnormal ciliary motility (HP:0012262)4.20877172
7Abnormal respiratory motile cilium morphology (HP:0005938)4.15258199
8Abnormal respiratory epithelium morphology (HP:0012253)4.15258199
9Volvulus (HP:0002580)4.12936322
10Recurrent cutaneous fungal infections (HP:0011370)3.76111219
11Chronic mucocutaneous candidiasis (HP:0002728)3.76111219
12Chromsome breakage (HP:0040012)3.74672691
13Panhypogammaglobulinemia (HP:0003139)3.54925036
14Abnormal delayed hypersensitivity skin test (HP:0002963)3.37166396
15Recurrent fungal infections (HP:0002841)3.15448536
16Rhinitis (HP:0012384)3.07253402
17T lymphocytopenia (HP:0005403)3.01160731
18Ectopic kidney (HP:0000086)3.01002182
19Abnormality of cells of the erythroid lineage (HP:0012130)3.00089463
20Duplicated collecting system (HP:0000081)2.95902617
21Abnormality of T cell number (HP:0011839)2.87197231
22Abnormality of T cells (HP:0002843)2.81341757
23Septo-optic dysplasia (HP:0100842)2.76893324
24Parakeratosis (HP:0001036)2.75961808
25Tubulointerstitial nephritis (HP:0001970)2.73407050
26Abnormality of B cell number (HP:0010975)2.72591534
27Congenital stationary night blindness (HP:0007642)2.72567350
28Abnormality of T cell physiology (HP:0011840)2.63911441
29Nephronophthisis (HP:0000090)2.61528143
30Absent rod-and cone-mediated responses on ERG (HP:0007688)2.59895898
31Agammaglobulinemia (HP:0004432)2.59838346
32Chronic sinusitis (HP:0011109)2.57131192
33Abnormality of the renal collecting system (HP:0004742)2.55804514
34Severe combined immunodeficiency (HP:0004430)2.50411438
35Aplasia/Hypoplasia of the spleen (HP:0010451)2.43714394
36Respiratory difficulties (HP:0002880)2.38163982
37Abnormality of the renal cortex (HP:0011035)2.37761051
38B lymphocytopenia (HP:0010976)2.33523587
39Abnormal number of erythroid precursors (HP:0012131)2.32925645
40Truncal obesity (HP:0001956)2.30822732
41Asplenia (HP:0001746)2.30598806
42Supernumerary bones of the axial skeleton (HP:0009144)2.30301753
43Abnormality of the renal medulla (HP:0100957)2.28939973
44Dyschromatopsia (HP:0007641)2.26439397
45Decreased central vision (HP:0007663)2.25016487
46Abnormality of the preputium (HP:0100587)2.22764558
47Attenuation of retinal blood vessels (HP:0007843)2.22572377
48Acute lymphatic leukemia (HP:0006721)2.21976371
49Encephalitis (HP:0002383)2.21869407
50Aplasia/Hypoplasia of the uvula (HP:0010293)2.21729926
51Molar tooth sign on MRI (HP:0002419)2.21291334
52Abnormality of midbrain morphology (HP:0002418)2.21291334
53Constricted visual fields (HP:0001133)2.20484598
54Pallor (HP:0000980)2.19280831
55Duplication of thumb phalanx (HP:0009942)2.18608945
56Prostate neoplasm (HP:0100787)2.15490254
57Facial hemangioma (HP:0000329)2.15162588
58Congenital sensorineural hearing impairment (HP:0008527)2.15077435
59True hermaphroditism (HP:0010459)2.13543242
60Meckel diverticulum (HP:0002245)2.10456594
61Delayed CNS myelination (HP:0002188)2.08777397
62Absent septum pellucidum (HP:0001331)2.08411036
63Reticulocytopenia (HP:0001896)2.08362774
64Median cleft lip (HP:0000161)2.08005248
65Abnormality of the ileum (HP:0001549)2.07468031
66Oligodactyly (hands) (HP:0001180)2.06147055
67Congenital, generalized hypertrichosis (HP:0004540)2.05994833
68Inflammation of the large intestine (HP:0002037)2.05185065
69Gastrointestinal inflammation (HP:0004386)2.04984799
70Lip pit (HP:0100267)2.04871684
71Abnormal rod and cone electroretinograms (HP:0008323)2.04807495
72Bile duct proliferation (HP:0001408)2.03893129
73Abnormal biliary tract physiology (HP:0012439)2.03893129
74Bronchiectasis (HP:0002110)2.03182885
75Acute necrotizing encephalopathy (HP:0006965)2.02255341
76Abnormality of the dental pulp (HP:0006479)2.01306697
77Postaxial foot polydactyly (HP:0001830)2.00654715
78Preaxial hand polydactyly (HP:0001177)1.99760460
79Small hand (HP:0200055)1.99412827
80Abnormality of secondary sexual hair (HP:0009888)1.99406122
81Abnormality of the axillary hair (HP:0100134)1.99406122
82Abnormality of molar (HP:0011077)1.98685057
83Abnormality of molar morphology (HP:0011070)1.98685057
84Medial flaring of the eyebrow (HP:0010747)1.98549178
85Pancreatic fibrosis (HP:0100732)1.98407528
86Clubbing of toes (HP:0100760)1.98292223
87Thyroiditis (HP:0100646)1.97818935
88Pendular nystagmus (HP:0012043)1.97338367
89Abnormality of the septum pellucidum (HP:0007375)1.96718818
90Recurrent viral infections (HP:0004429)1.96464392
91Recurrent skin infections (HP:0001581)1.95990594
92Progressive microcephaly (HP:0000253)1.95811618
93Elevated erythrocyte sedimentation rate (HP:0003565)1.95503152
94White forelock (HP:0002211)1.94976388
95Abnormal hair whorl (HP:0010721)1.94081788
96Meningitis (HP:0001287)1.93348179
97Increased CSF lactate (HP:0002490)1.93140859
98Retinal dysplasia (HP:0007973)1.91971423
99Abnormality of DNA repair (HP:0003254)1.90606041
100Supernumerary spleens (HP:0009799)1.89101620
101Patchy hypopigmentation of hair (HP:0011365)1.88917622
102Generalized hypopigmentation of hair (HP:0011358)1.88268078
103Chronic hepatic failure (HP:0100626)1.87411890
104Abnormality of the dental root (HP:0006486)1.87319018
105Taurodontia (HP:0000679)1.87319018
106Abnormality of permanent molar morphology (HP:0011071)1.87319018
107Mitochondrial inheritance (HP:0001427)1.87180755
108Nephroblastoma (Wilms tumor) (HP:0002667)1.86529669
109Bony spicule pigmentary retinopathy (HP:0007737)1.86306942
110Recurrent sinusitis (HP:0011108)1.84995311
111Aplasia/Hypoplasia of the tibia (HP:0005772)1.84630890
112Progressive macrocephaly (HP:0004481)1.83877498
1133-Methylglutaconic aciduria (HP:0003535)1.83414361
114Stomatitis (HP:0010280)1.82375548
115Aplasia cutis congenita (HP:0001057)1.81773859
116Abnormal mitochondria in muscle tissue (HP:0008316)1.81120597
117Absent thumb (HP:0009777)1.80640772
118Chronic bronchitis (HP:0004469)1.80151060
119Atelectasis (HP:0100750)1.79378697
120Impulsivity (HP:0100710)1.79317557
121Intestinal atresia (HP:0011100)1.79078955
122Combined immunodeficiency (HP:0005387)1.78687251
123Optic nerve hypoplasia (HP:0000609)1.78081436
124Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.78061382
125Optic disc pallor (HP:0000543)1.77992122
126Protruding tongue (HP:0010808)1.77556738
127Autoimmune hemolytic anemia (HP:0001890)1.75802212
128Severe visual impairment (HP:0001141)1.74497551
129Self-mutilation (HP:0000742)1.74134683
130Recurrent abscess formation (HP:0002722)1.73729143
131Adrenal hypoplasia (HP:0000835)1.72277684
132Abnormality of incisor morphology (HP:0011063)1.72184167
133Acute encephalopathy (HP:0006846)1.72098952
134Congenital hepatic fibrosis (HP:0002612)1.71891531
135Highly arched eyebrow (HP:0002553)1.71783730
136Anomalous pulmonary venous return (HP:0010772)1.71227688
137Neoplasm of the adrenal cortex (HP:0100641)1.70559084
138Cystic liver disease (HP:0006706)1.70034113
139Renal dysplasia (HP:0000110)1.69819165
140Embryonal renal neoplasm (HP:0011794)1.69766053
141Stomach cancer (HP:0012126)1.69424076
142Mediastinal lymphadenopathy (HP:0100721)1.68524454
143Choroideremia (HP:0001139)1.68319935
144Hyperventilation (HP:0002883)1.68247989
145Tubular atrophy (HP:0000092)1.68089478
146Male pseudohermaphroditism (HP:0000037)1.68053555
147Facial cleft (HP:0002006)1.67942534
148Fair hair (HP:0002286)1.67756991
149Albinism (HP:0001022)1.67221524
150Aplasia/Hypoplasia of the thymus (HP:0010515)1.66796641
151Conical tooth (HP:0000698)1.66761346
152Rib fusion (HP:0000902)1.62315529
153Pancreatic cysts (HP:0001737)1.61742228
154Febrile seizures (HP:0002373)1.59290033
155Abnormality of the parietal bone (HP:0002696)1.57162550
156Aganglionic megacolon (HP:0002251)1.55478618
157Abnormality of chromosome stability (HP:0003220)1.55178103
158Triphalangeal thumb (HP:0001199)1.54077092
159Abnormality of the nasal septum (HP:0000419)1.53419999
160Abnormal sex determination (HP:0012244)1.52845446
161Sex reversal (HP:0012245)1.52845446
162Osteomalacia (HP:0002749)1.51013250
163Intestinal fistula (HP:0100819)1.50825347
164Cupped ear (HP:0000378)1.50534940
165Astigmatism (HP:0000483)1.50511501
166Anencephaly (HP:0002323)1.50398864
167Abnormality of the fingertips (HP:0001211)1.49128760
168Renal agenesis (HP:0000104)1.48884897
169Abnormality of the incisor (HP:0000676)1.48536201
170Partial duplication of thumb phalanx (HP:0009944)1.47884111
171Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.47743929
172Nephrogenic diabetes insipidus (HP:0009806)1.47427848
173Upper limb muscle weakness (HP:0003484)1.46339491
174Postaxial hand polydactyly (HP:0001162)1.45507966
175Ectopic anus (HP:0004397)1.45332277

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FES3.36607234
2CASK3.18295723
3ACVR1B3.07301706
4RIPK42.96384975
5MAP4K12.71466813
6BMPR1B2.55611577
7FRK2.50894573
8TNIK2.49787287
9CDK122.44543806
10CDK82.42016221
11GRK12.16290428
12BLK2.10358524
13TXK1.99983799
14MAP2K31.99744976
15MATK1.97463725
16KIT1.93447106
17TAOK31.90087594
18IRAK41.81036437
19CDK31.79621330
20GRK61.77663680
21LATS11.73581072
22ADRBK21.72114379
23MAPK151.71573508
24YES11.70091423
25MKNK21.69980824
26PKN11.69574406
27SRPK11.61978658
28INSRR1.61271455
29MAPKAPK31.57750283
30CSK1.56094080
31MAP3K91.53225869
32MAPK131.52741254
33SYK1.51897037
34MAP3K141.48132833
35NEK61.45550499
36IRAK31.45231112
37MAP3K111.43577582
38EIF2AK21.43093532
39BRD41.43018082
40TAOK21.40756508
41STK391.38176215
42PRPF4B1.37615766
43MAP2K21.36467052
44ZAK1.35233502
45CLK11.33383906
46SIK21.31812023
47TYK21.31420867
48IRAK21.30110851
49PNCK1.22396382
50GRK71.19618263
51TYRO31.17014285
52SIK31.16763347
53CHEK21.15289087
54NTRK31.15186258
55TNK21.15022998
56CDK71.13528676
57TAOK11.11064427
58PLK41.08797574
59BMPR21.08734025
60VRK21.08351934
61IRAK11.07613945
62CAMK1G1.02916070
63STK161.00869908
64LCK0.95481979
65MARK20.93871105
66IKBKE0.93311281
67BUB10.93236490
68TRPM70.93226314
69HCK0.90584602
70DYRK20.90257571
71VRK10.89349104
72MAP2K60.88944136
73MKNK10.88443092
74MAP3K60.87768634
75ATR0.87008520
76TESK20.87001453
77WNK10.86478143
78PBK0.85599720
79ICK0.84218273
80CDC70.83906118
81ADRBK10.83619820
82NME10.83226426
83MAP3K70.82338215
84MAP3K10.82298237
85NTRK20.82027752
86MELK0.81601668
87TTK0.80609618
88STK100.80244153
89IKBKB0.77600576
90TGFBR10.77009656
91STK30.74564949
92RAF10.74250709
93HIPK20.74244584
94NLK0.73747648
95ERBB30.73233786
96MAP2K10.73210039
97ITK0.72594005
98TEC0.72267563
99AKT30.71447041
100MAP3K30.71371850
101PTK2B0.70981260
102BTK0.68847228
103MAPKAPK50.68745161
104CDK90.67287291
105PIK3CG0.66561564
106PRKCQ0.65174223
107ATM0.64607042
108RPS6KB20.64259448
109MAPK70.64070863
110NEK20.62019050
111CAMK1D0.61888144
112CHUK0.61492207
113PRKD20.61382170
114TLK10.60973690
115MST40.60956140
116PRKCH0.60754719
117OXSR10.59707032
118DYRK30.59002514
119STK40.58202982
120UHMK10.58093179
121RPS6KA50.57236533
122MUSK0.57217396
123SGK2230.56937690
124SGK4940.56937690
125CDK40.56504906
126MARK30.56391645
127CHEK10.55430842
128CAMKK10.54149040
129MAP4K20.53474034
130EPHB20.52946365
131RPS6KA60.50906391
132BCR0.50469037
133TAF10.49638985
134MAPK120.49468122
135MAP2K70.48505941
136FGR0.47949484
137MAPK100.47065282
138MAP3K130.46951194
139TIE10.46697628
140DMPK0.46522136
141SGK20.46286934
142CAMKK20.46134005
143GSK3B0.46076940
144LYN0.45622668
145DYRK1A0.44170881
146WNK30.44020441
147PRKG10.43926097
148MAPK140.43558000
149CAMK40.42667544
150NUAK10.42565525
151CDK10.41906476
152CCNB10.41359306
153JAK30.40801053
154WNK40.40453749
155TBK10.39145471
156KSR20.38760760
157WEE10.38602818
158STK110.37596856
159ALK0.36879917
160ZAP700.36876034
161EIF2AK30.34845153
162PDK10.33916316
163PRKCI0.32165248
164PLK20.31891346
165MAPKAPK20.30221832
166CSF1R0.29545447

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.11818439
2Phototransduction_Homo sapiens_hsa047442.88621265
3Fanconi anemia pathway_Homo sapiens_hsa034602.61248805
4Basal transcription factors_Homo sapiens_hsa030222.51969323
5Autoimmune thyroid disease_Homo sapiens_hsa053202.07325610
6Fc epsilon RI signaling pathway_Homo sapiens_hsa046642.01095226
7Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.87687139
8Homologous recombination_Homo sapiens_hsa034401.85866889
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.85834130
10Allograft rejection_Homo sapiens_hsa053301.67864857
11Regulation of autophagy_Homo sapiens_hsa041401.64341874
12Primary immunodeficiency_Homo sapiens_hsa053401.55747352
13Non-homologous end-joining_Homo sapiens_hsa034501.53695461
14Graft-versus-host disease_Homo sapiens_hsa053321.46990821
15Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.42864054
16Olfactory transduction_Homo sapiens_hsa047401.38740497
17Sphingolipid metabolism_Homo sapiens_hsa006001.37760977
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.36147557
19Intestinal immune network for IgA production_Homo sapiens_hsa046721.34001366
20Ether lipid metabolism_Homo sapiens_hsa005651.32747388
21Taste transduction_Homo sapiens_hsa047421.30390122
22Nicotine addiction_Homo sapiens_hsa050331.29991970
23NF-kappa B signaling pathway_Homo sapiens_hsa040641.27531296
24Leishmaniasis_Homo sapiens_hsa051401.26182435
25Oxidative phosphorylation_Homo sapiens_hsa001901.24561642
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.22721008
27Asthma_Homo sapiens_hsa053101.18867393
28Arachidonic acid metabolism_Homo sapiens_hsa005901.16777074
29Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.15707069
30Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.13241448
31Butanoate metabolism_Homo sapiens_hsa006501.12409296
32Basal cell carcinoma_Homo sapiens_hsa052171.11541707
33Hematopoietic cell lineage_Homo sapiens_hsa046401.11293818
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.10443184
35mRNA surveillance pathway_Homo sapiens_hsa030151.10313237
36RNA degradation_Homo sapiens_hsa030181.10304313
37Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.06624367
38Renal cell carcinoma_Homo sapiens_hsa052111.06438994
39Measles_Homo sapiens_hsa051621.04747480
40Spliceosome_Homo sapiens_hsa030401.04545380
41One carbon pool by folate_Homo sapiens_hsa006701.00679199
42Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.00203487
43Morphine addiction_Homo sapiens_hsa050320.98346259
44Linoleic acid metabolism_Homo sapiens_hsa005910.98039614
45Wnt signaling pathway_Homo sapiens_hsa043100.96784639
46RNA polymerase_Homo sapiens_hsa030200.96028335
47Herpes simplex infection_Homo sapiens_hsa051680.95767732
48Transcriptional misregulation in cancer_Homo sapiens_hsa052020.95331261
49Pyrimidine metabolism_Homo sapiens_hsa002400.94847826
50Serotonergic synapse_Homo sapiens_hsa047260.93449467
51Parkinsons disease_Homo sapiens_hsa050120.93164070
52Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.92657659
53DNA replication_Homo sapiens_hsa030300.92656087
54Acute myeloid leukemia_Homo sapiens_hsa052210.92038072
55Other glycan degradation_Homo sapiens_hsa005110.90620936
56Antigen processing and presentation_Homo sapiens_hsa046120.90603932
57alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.89640398
58Mismatch repair_Homo sapiens_hsa034300.89245707
59Axon guidance_Homo sapiens_hsa043600.87249596
60Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.87229956
61Huntingtons disease_Homo sapiens_hsa050160.85908888
62Glutamatergic synapse_Homo sapiens_hsa047240.85805603
63Hedgehog signaling pathway_Homo sapiens_hsa043400.83543220
64Tuberculosis_Homo sapiens_hsa051520.82702243
65Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.81611805
66ABC transporters_Homo sapiens_hsa020100.80060764
67Jak-STAT signaling pathway_Homo sapiens_hsa046300.79988898
68Platelet activation_Homo sapiens_hsa046110.78349562
69Rheumatoid arthritis_Homo sapiens_hsa053230.76420366
70Chemical carcinogenesis_Homo sapiens_hsa052040.74345973
71Non-small cell lung cancer_Homo sapiens_hsa052230.73357758
72Base excision repair_Homo sapiens_hsa034100.73259265
73Cholinergic synapse_Homo sapiens_hsa047250.72786606
74Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.72741945
75T cell receptor signaling pathway_Homo sapiens_hsa046600.72603038
76Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.72203652
77Oxytocin signaling pathway_Homo sapiens_hsa049210.71437705
78Notch signaling pathway_Homo sapiens_hsa043300.70709110
79Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.70400176
80Calcium signaling pathway_Homo sapiens_hsa040200.70354889
81Glycerophospholipid metabolism_Homo sapiens_hsa005640.68751462
82Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.68638786
83Cell cycle_Homo sapiens_hsa041100.67239930
84SNARE interactions in vesicular transport_Homo sapiens_hsa041300.67155492
85Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.65798874
86Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.65218862
87Pancreatic cancer_Homo sapiens_hsa052120.63575593
88Chemokine signaling pathway_Homo sapiens_hsa040620.63218599
89Phospholipase D signaling pathway_Homo sapiens_hsa040720.62608530
90Nucleotide excision repair_Homo sapiens_hsa034200.62464537
91NOD-like receptor signaling pathway_Homo sapiens_hsa046210.62112851
92Purine metabolism_Homo sapiens_hsa002300.61130415
93Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.60640384
94Phosphatidylinositol signaling system_Homo sapiens_hsa040700.59895858
95Circadian rhythm_Homo sapiens_hsa047100.59705053
96Malaria_Homo sapiens_hsa051440.59637394
97Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.59149497
98Type I diabetes mellitus_Homo sapiens_hsa049400.58330729
99Ras signaling pathway_Homo sapiens_hsa040140.58166002
100Ovarian steroidogenesis_Homo sapiens_hsa049130.56885596
101RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.55863965
102Toll-like receptor signaling pathway_Homo sapiens_hsa046200.55715507
103Osteoclast differentiation_Homo sapiens_hsa043800.54929830
104p53 signaling pathway_Homo sapiens_hsa041150.54767768
105Circadian entrainment_Homo sapiens_hsa047130.54650387
106Nitrogen metabolism_Homo sapiens_hsa009100.54002341
107Vitamin B6 metabolism_Homo sapiens_hsa007500.53422668
108African trypanosomiasis_Homo sapiens_hsa051430.53042792
109GnRH signaling pathway_Homo sapiens_hsa049120.52827456
110B cell receptor signaling pathway_Homo sapiens_hsa046620.52811634
111Epstein-Barr virus infection_Homo sapiens_hsa051690.51587853
112Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51070504
113Pathways in cancer_Homo sapiens_hsa052000.49878334
114Toxoplasmosis_Homo sapiens_hsa051450.49783345
115Dorso-ventral axis formation_Homo sapiens_hsa043200.48857651
116Hepatitis B_Homo sapiens_hsa051610.48557278
117MicroRNAs in cancer_Homo sapiens_hsa052060.48506354
118cAMP signaling pathway_Homo sapiens_hsa040240.47551130
119Inositol phosphate metabolism_Homo sapiens_hsa005620.47487554
120Vascular smooth muscle contraction_Homo sapiens_hsa042700.46746546
121MAPK signaling pathway_Homo sapiens_hsa040100.46725663
122Salivary secretion_Homo sapiens_hsa049700.46493669
123Alzheimers disease_Homo sapiens_hsa050100.46356768
124Systemic lupus erythematosus_Homo sapiens_hsa053220.46060954
125Influenza A_Homo sapiens_hsa051640.45959589
126Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.44921731
127HTLV-I infection_Homo sapiens_hsa051660.44854898
128GABAergic synapse_Homo sapiens_hsa047270.44764123
129Protein export_Homo sapiens_hsa030600.43977356
130Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.43913254
131Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.43428479
132Neurotrophin signaling pathway_Homo sapiens_hsa047220.42889736
133Prostate cancer_Homo sapiens_hsa052150.42716910
134Melanogenesis_Homo sapiens_hsa049160.40407655
135Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.39884401
136Hippo signaling pathway_Homo sapiens_hsa043900.39854088
137Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.39755130
138Choline metabolism in cancer_Homo sapiens_hsa052310.39491597
139Insulin secretion_Homo sapiens_hsa049110.38624296
140RNA transport_Homo sapiens_hsa030130.38394596
141Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.37920641

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