TCL1A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of acrosome reaction (GO:0060046)8.84421058
2regulation of female gonad development (GO:2000194)8.45710772
3positive regulation of humoral immune response (GO:0002922)7.49239714
4oocyte development (GO:0048599)7.40940716
5multicellular organism reproduction (GO:0032504)7.36862516
6regulation of DNA methylation (GO:0044030)6.91830395
7regulation of histone H3-K9 methylation (GO:0051570)6.46125274
8regulation of meiosis I (GO:0060631)6.16727990
9protein kinase C signaling (GO:0070528)6.14846873
10piRNA metabolic process (GO:0034587)5.97223507
11B cell receptor signaling pathway (GO:0050853)5.63492772
12meiotic cell cycle (GO:0051321)5.33654756
13negative regulation of histone methylation (GO:0031061)5.31562604
14immunoglobulin mediated immune response (GO:0016064)5.27485887
15negative regulation of reproductive process (GO:2000242)5.09200343
16reproduction (GO:0000003)4.97284484
17mitotic chromosome condensation (GO:0007076)4.94921881
18DNA methylation involved in gamete generation (GO:0043046)4.81425027
19positive regulation of histone H3-K4 methylation (GO:0051571)4.68764580
20binding of sperm to zona pellucida (GO:0007339)4.64079788
21female gamete generation (GO:0007292)4.47150538
22citrulline biosynthetic process (GO:0019240)4.44600375
23regulation of hypersensitivity (GO:0002883)4.43158279
24positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.29593620
25B cell mediated immunity (GO:0019724)4.29407857
26regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.94867965
27positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.78074252
28positive regulation of mitotic sister chromatid separation (GO:1901970)3.78074252
29positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.78074252
30sperm-egg recognition (GO:0035036)3.75097537
31regulation of B cell receptor signaling pathway (GO:0050855)3.73078921
32protein localization to chromosome, centromeric region (GO:0071459)3.66305219
33regulation of interferon-beta biosynthetic process (GO:0045357)3.64691512
34retinal cone cell development (GO:0046549)3.59954446
35regulation of histone methylation (GO:0031060)3.56035562
36positive regulation of histone methylation (GO:0031062)3.52039722
37positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.51241114
38DNA alkylation (GO:0006305)3.49539018
39DNA methylation (GO:0006306)3.49539018
40regulation of steroid hormone secretion (GO:2000831)3.46558416
41gene silencing by RNA (GO:0031047)3.45462163
42single fertilization (GO:0007338)3.45088704
43positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.41582708
44positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.40524273
45fertilization (GO:0009566)3.33616676
46negative regulation of cAMP-mediated signaling (GO:0043951)3.33584878
47positive regulation of interleukin-4 production (GO:0032753)3.30054520
48protein localization to kinetochore (GO:0034501)3.26385100
49positive regulation of isotype switching (GO:0045830)3.23754920
50synapsis (GO:0007129)3.21785136
51positive regulation of chromosome segregation (GO:0051984)3.21737455
52regulation of RNA export from nucleus (GO:0046831)3.20985762
53cell-cell recognition (GO:0009988)3.20785873
54antigen processing and presentation of endogenous antigen (GO:0019883)3.18341528
55regulation of chromatin binding (GO:0035561)3.15433606
56histone H3-K36 demethylation (GO:0070544)3.15284495
57regulation of histone H3-K4 methylation (GO:0051569)3.13821736
58B cell proliferation (GO:0042100)3.11550784
59regulation of germinal center formation (GO:0002634)3.10007273
60regulation of chromatin silencing (GO:0031935)3.08566957
61positive regulation of B cell differentiation (GO:0045579)3.05303808
62positive thymic T cell selection (GO:0045059)3.03545015
63regulation of interleukin-4 production (GO:0032673)3.03368241
64regulation of antigen processing and presentation (GO:0002577)3.02985140
65regulation of cell maturation (GO:1903429)3.02918157
66negative regulation of histone modification (GO:0031057)2.99767783
67positive regulation of DNA recombination (GO:0045911)2.99615895
68interkinetic nuclear migration (GO:0022027)2.98389962
69N-terminal protein amino acid acetylation (GO:0006474)2.98065796
70regulation of dendritic cell antigen processing and presentation (GO:0002604)2.97121837
71protein localization to chromosome (GO:0034502)2.96558835
72positive regulation of gene expression, epigenetic (GO:0045815)2.96247851
73positive regulation of gamma-delta T cell activation (GO:0046645)2.93811601
74synaptonemal complex assembly (GO:0007130)2.90547163
75regulation of acute inflammatory response to antigenic stimulus (GO:0002864)2.88857160
76defense response to protozoan (GO:0042832)2.88647941
77centriole replication (GO:0007099)2.83901485
78negative regulation of chromatin modification (GO:1903309)2.83459939
79attachment of spindle microtubules to kinetochore (GO:0008608)2.82442042
80primitive streak formation (GO:0090009)2.82217480
81negative regulation of gene silencing (GO:0060969)2.81474647
82establishment of chromosome localization (GO:0051303)2.80782690
83positive regulation of reproductive process (GO:2000243)2.79460184
84gene silencing (GO:0016458)2.77770215
85positive regulation of B cell activation (GO:0050871)2.76348839
86chromosome organization involved in meiosis (GO:0070192)2.76306135
87negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.75249631
88histone H3-K4 methylation (GO:0051568)2.74366603
89mitotic metaphase plate congression (GO:0007080)2.72828995
90regulation of phospholipid biosynthetic process (GO:0071071)2.71524757
91phosphatidylinositol dephosphorylation (GO:0046856)2.70894113
92regulation of mast cell degranulation (GO:0043304)2.70613307
93DNA methylation or demethylation (GO:0044728)2.69879676
94regulation of B cell differentiation (GO:0045577)2.69062440
95male meiosis I (GO:0007141)2.69008112
96regulation of reproductive process (GO:2000241)2.67969648
97DNA replication checkpoint (GO:0000076)2.67775829
98regulation of interferon-gamma biosynthetic process (GO:0045072)2.65524544
99oogenesis (GO:0048477)2.64611081
100antigen receptor-mediated signaling pathway (GO:0050851)2.61948650

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.30164724
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.39719780
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.81908183
4MYC_22102868_ChIP-Seq_BL_Human3.75914540
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.70214484
6FOXM1_23109430_ChIP-Seq_U2OS_Human2.91512253
7E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.81886101
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.70807599
9IRF8_21731497_ChIP-ChIP_J774_Mouse2.64051612
10SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.53099550
11MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.51432690
12NOTCH1_21737748_ChIP-Seq_TLL_Human2.49051030
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.42140047
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.17536791
15E2F4_17652178_ChIP-ChIP_JURKAT_Human2.16390458
16STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.13818854
17VDR_21846776_ChIP-Seq_THP-1_Human2.00035185
18EZH2_22144423_ChIP-Seq_EOC_Human12.6625951
19BP1_19119308_ChIP-ChIP_Hs578T_Human1.87380951
20CIITA_25753668_ChIP-Seq_RAJI_Human1.85081804
21EGR1_19374776_ChIP-ChIP_THP-1_Human1.75132736
22FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.74357860
23MYB_26560356_Chip-Seq_TH1_Human1.69900798
24VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.68372005
25* MYB_26560356_Chip-Seq_TH2_Human1.62320025
26RUNX_20019798_ChIP-Seq_JUKART_Human1.58186237
27MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.57057286
28VDR_24763502_ChIP-Seq_THP-1_Human1.52795689
29SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.49349662
30FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.49030628
31UTX_26944678_Chip-Seq_JUKART_Human1.46719329
32KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.43770159
33KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.43770159
34KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.43770159
35SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.41559056
36SCL_19346495_ChIP-Seq_HPC-7_Human1.36274237
37FOXP3_21729870_ChIP-Seq_TREG_Human1.35438807
38IRF8_27001747_Chip-Seq_BMDM_Mouse1.35353566
39PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.35140293
40SPI1_23547873_ChIP-Seq_NB4_Human1.33901821
41SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.31172662
42TP63_19390658_ChIP-ChIP_HaCaT_Human1.30132340
43MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.28619921
44SPI1_23127762_ChIP-Seq_K562_Human1.28214081
45STAT6_21828071_ChIP-Seq_BEAS2B_Human1.26667791
46STAT4_19710469_ChIP-ChIP_TH1__Mouse1.18482458
47IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.17350402
48GATA3_27048872_Chip-Seq_THYMUS_Human1.16427040
49SMRT_27268052_Chip-Seq_Bcells_Human1.15995970
50TCF7_22412390_ChIP-Seq_EML_Mouse1.15399709
51MAF_26560356_Chip-Seq_TH1_Human1.14857312
52RUNX1_22412390_ChIP-Seq_EML_Mouse1.13172937
53MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.11394206
54RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03994306
55POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.03637588
56HOXB4_20404135_ChIP-ChIP_EML_Mouse1.02918581
57MYB_21317192_ChIP-Seq_ERMYB_Mouse1.01967758
58BCL6_27268052_Chip-Seq_Bcells_Human1.01777627
59E2F1_21310950_ChIP-Seq_MCF-7_Human1.00454169
60BCOR_27268052_Chip-Seq_Bcells_Human0.99043860
61VDR_23849224_ChIP-Seq_CD4+_Human0.97545279
62NANOG_18555785_ChIP-Seq_MESCs_Mouse0.96046677
63GATA3_26560356_Chip-Seq_TH1_Human0.94873369
64RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.94494572
65P300_27268052_Chip-Seq_Bcells_Human0.93721641
66KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.90836614
67HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.90626065
68TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88860670
69FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.88718973
70TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.88594270
71SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.88516769
72ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.87969776
73MAF_26560356_Chip-Seq_TH2_Human0.87681549
74BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.87056645
75PU.1_20513432_ChIP-Seq_Bcells_Mouse0.86371711
76GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86057027
77NANOG_20526341_ChIP-Seq_ESCs_Human0.83315990
78PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.81785585
79GATA1_19941827_ChIP-Seq_MEL86_Mouse0.81681500
80HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.81350591
81ERG_20887958_ChIP-Seq_HPC-7_Mouse0.80595567
82BRD4_27068464_Chip-Seq_AML-cells_Mouse0.79249941
83OCT4_19829295_ChIP-Seq_ESCs_Human0.79139360
84HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.78298172
85TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.77500334
86GATA2_22383799_ChIP-Seq_G1ME_Mouse0.76762511
87SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.76201648
88GATA1_19941827_ChIP-Seq_MEL_Mouse0.75242976
89YY1_21170310_ChIP-Seq_MESCs_Mouse0.74349403
90GATA3_26560356_Chip-Seq_TH2_Human0.74107590
91GATA1_22383799_ChIP-Seq_G1ME_Mouse0.74103272
92P68_20966046_ChIP-Seq_HELA_Human0.72255016
93ELK4_26923725_Chip-Seq_MESODERM_Mouse0.71642768
94KDM2B_26808549_Chip-Seq_SUP-B15_Human0.68753865
95* CTCF_21964334_Chip-Seq_Bcells_Human0.68622425
96GATA1_26923725_Chip-Seq_HPCs_Mouse0.68394295
97P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.68009599
98CTCF_26484167_Chip-Seq_Bcells_Mouse0.67054722
99ETS1_22383799_ChIP-Seq_G1ME_Mouse0.66663904
100ELF1_17652178_ChIP-ChIP_JURKAT_Human0.66326040

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003718_maternal_effect5.86277522
2MP0008877_abnormal_DNA_methylation3.77028492
3MP0002138_abnormal_hepatobiliary_system3.48872173
4MP0008057_abnormal_DNA_replication3.47315433
5MP0001790_abnormal_immune_system3.15558456
6MP0005387_immune_system_phenotype3.15558456
7MP0003693_abnormal_embryo_hatching3.11988993
8MP0006292_abnormal_olfactory_placode3.08797626
9MP0001800_abnormal_humoral_immune3.02751275
10MP0003183_abnormal_peptide_metabolism2.94671303
11MP0001835_abnormal_antigen_presentation2.74544419
12MP0002139_abnormal_hepatobiliary_system2.62549374
13MP0010094_abnormal_chromosome_stability2.51904901
14MP0000685_abnormal_immune_system2.47418801
15MP0003077_abnormal_cell_cycle2.41334157
16MP0002452_abnormal_antigen_presenting2.26121279
17MP0005395_other_phenotype2.17212822
18MP0003699_abnormal_female_reproductive2.16618411
19MP0008058_abnormal_DNA_repair2.15875935
20MP0002420_abnormal_adaptive_immunity2.15543461
21MP0001929_abnormal_gametogenesis2.13562132
22MP0003111_abnormal_nucleus_morphology2.12590892
23MP0002398_abnormal_bone_marrow2.09742148
24MP0001819_abnormal_immune_cell2.06597149
25MP0002723_abnormal_immune_serum2.05099495
26MP0005671_abnormal_response_to2.00901391
27MP0003763_abnormal_thymus_physiology1.99947442
28MP0005075_abnormal_melanosome_morpholog1.99667056
29MP0008789_abnormal_olfactory_epithelium1.95756921
30MP0005000_abnormal_immune_tolerance1.92966247
31MP0005394_taste/olfaction_phenotype1.88560320
32MP0005499_abnormal_olfactory_system1.88560320
33MP0000015_abnormal_ear_pigmentation1.84419557
34MP0000689_abnormal_spleen_morphology1.82393771
35MP0002210_abnormal_sex_determination1.76268788
36MP0000716_abnormal_immune_system1.70697945
37MP0002396_abnormal_hematopoietic_system1.65020373
38MP0001730_embryonic_growth_arrest1.57453880
39MP0002722_abnormal_immune_system1.52111369
40MP0003436_decreased_susceptibility_to1.46891175
41MP0003890_abnormal_embryonic-extraembry1.46117402
42MP0003303_peritoneal_inflammation1.43330499
43MP0000653_abnormal_sex_gland1.42042122
44MP0005025_abnormal_response_to1.40764051
45MP0005645_abnormal_hypothalamus_physiol1.37381429
46MP0001119_abnormal_female_reproductive1.36324284
47MP0002429_abnormal_blood_cell1.35970985
48MP0000703_abnormal_thymus_morphology1.27357345
49MP0002161_abnormal_fertility/fecundity1.26035627
50MP0010307_abnormal_tumor_latency1.25517819
51MP0002419_abnormal_innate_immunity1.21027676
52MP0009785_altered_susceptibility_to1.17204370
53MP0001986_abnormal_taste_sensitivity1.15627602
54MP0003950_abnormal_plasma_membrane1.12091194
55MP0000350_abnormal_cell_proliferation1.11742651
56MP0005310_abnormal_salivary_gland1.10787921
57MP0002019_abnormal_tumor_incidence1.10751885
58MP0002928_abnormal_bile_duct1.10193993
59MP0002148_abnormal_hypersensitivity_rea1.08591753
60MP0000465_gastrointestinal_hemorrhage1.06274581
61MP0003252_abnormal_bile_duct1.05225657
62MP0003172_abnormal_lysosome_physiology1.04968970
63MP0001145_abnormal_male_reproductive1.03198111
64MP0010234_abnormal_vibrissa_follicle1.00037345
65MP0004381_abnormal_hair_follicle0.99207190
66MP0005174_abnormal_tail_pigmentation0.98958081
67MP0002405_respiratory_system_inflammati0.98235853
68MP0010155_abnormal_intestine_physiology0.96396850
69MP0004957_abnormal_blastocyst_morpholog0.94118315
70MP0000313_abnormal_cell_death0.91898425
71MP0009840_abnormal_foam_cell0.85620275
72MP0005360_urolithiasis0.85380774
73MP0003879_abnormal_hair_cell0.85255696
74MP0009333_abnormal_splenocyte_physiolog0.83686996
75MP0005410_abnormal_fertilization0.81195028
76MP0000490_abnormal_crypts_of0.80305630
77MP0003698_abnormal_male_reproductive0.79363340
78MP0001845_abnormal_inflammatory_respons0.78563377
79MP0005389_reproductive_system_phenotype0.78403575
80MP0001672_abnormal_embryogenesis/_devel0.73642552
81MP0005380_embryogenesis_phenotype0.73642552
82MP0003959_abnormal_lean_body0.73403024
83MP0003121_genomic_imprinting0.70404926
84MP0002095_abnormal_skin_pigmentation0.69393768
85MP0001764_abnormal_homeostasis0.66580054
86MP0002163_abnormal_gland_morphology0.64050739
87MP0001919_abnormal_reproductive_system0.63928158
88MP0004808_abnormal_hematopoietic_stem0.61773895
89MP0010368_abnormal_lymphatic_system0.61732936
90MP0002234_abnormal_pharynx_morphology0.61495406
91MP0005464_abnormal_platelet_physiology0.61075802
92MP0008469_abnormal_protein_level0.59709018
93MP0008932_abnormal_embryonic_tissue0.59618826
94MP0008004_abnormal_stomach_pH0.55170373
95MP0004947_skin_inflammation0.54416104
96MP0005621_abnormal_cell_physiology0.53597529
97MP0002006_tumorigenesis0.53217152
98MP0005501_abnormal_skin_physiology0.52864855
99MP0001666_abnormal_nutrient_absorption0.51361992
100MP0002166_altered_tumor_susceptibility0.50411447

Predicted human phenotypes

RankGene SetZ-score
1Agammaglobulinemia (HP:0004432)8.20618261
2Gastrointestinal stroma tumor (HP:0100723)5.48879315
3Cellulitis (HP:0100658)5.41770089
4Osteomyelitis (HP:0002754)4.76754979
5Recurrent bronchitis (HP:0002837)4.75400277
6Meningitis (HP:0001287)4.60508460
7Recurrent pneumonia (HP:0006532)4.59738110
8Verrucae (HP:0200043)4.18444787
9Papilloma (HP:0012740)4.18444787
10Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)4.08585417
11Recurrent sinusitis (HP:0011108)4.06521230
12Chronic sinusitis (HP:0011109)3.96702751
13Recurrent lower respiratory tract infections (HP:0002783)3.83908527
14Eczematoid dermatitis (HP:0000976)3.79337005
15Impulsivity (HP:0100710)3.76280018
16Abnormality of macrophages (HP:0004311)3.67381035
17Chromosomal breakage induced by crosslinking agents (HP:0003221)3.49052075
18Chromsome breakage (HP:0040012)3.42560632
19Recurrent bacterial skin infections (HP:0005406)3.39123434
20Lymphopenia (HP:0001888)3.39042290
21Aplasia/Hypoplasia of the fovea (HP:0008060)3.34862748
22Hypoplasia of the fovea (HP:0007750)3.34862748
23Facial hemangioma (HP:0000329)3.33031077
24Hypergonadotropic hypogonadism (HP:0000815)3.30683727
25Mediastinal lymphadenopathy (HP:0100721)3.25453583
26Pulmonary fibrosis (HP:0002206)3.20221477
27Panhypogammaglobulinemia (HP:0003139)3.18632311
28Osteomalacia (HP:0002749)3.16052338
29Gastrointestinal inflammation (HP:0004386)3.12642134
30Inflammation of the large intestine (HP:0002037)3.12297049
31Recurrent gram-negative bacterial infections (HP:0005420)3.04159913
32Abnormality of cells of the lymphoid lineage (HP:0012140)3.04149824
33Sepsis (HP:0100806)2.98847830
34Lip pit (HP:0100267)2.95016913
35Recurrent viral infections (HP:0004429)2.93946539
36Colitis (HP:0002583)2.92882259
37Vasculitis (HP:0002633)2.91343587
38Emphysema (HP:0002097)2.89375440
39B lymphocytopenia (HP:0010976)2.86483171
40Abnormality of the fovea (HP:0000493)2.85078467
41Abdominal situs inversus (HP:0003363)2.84634814
42Abnormality of abdominal situs (HP:0011620)2.84634814
43Recurrent abscess formation (HP:0002722)2.81706593
44Recurrent fungal infections (HP:0002841)2.81387932
45Bronchitis (HP:0012387)2.76994810
46IgG deficiency (HP:0004315)2.76949952
47Skin rash (HP:0000988)2.74677878
48IgA deficiency (HP:0002720)2.73167479
49Recurrent otitis media (HP:0000403)2.68897050
50Cholecystitis (HP:0001082)2.67692906
51Abnormal gallbladder physiology (HP:0012438)2.67692906
52Chronic obstructive pulmonary disease (HP:0006510)2.63861413
53Obstructive lung disease (HP:0006536)2.63861413
54Supernumerary spleens (HP:0009799)2.59630391
55Abnormality of B cell number (HP:0010975)2.58013851
56Anterior segment dysgenesis (HP:0007700)2.54906479
57Diminished motivation (HP:0000745)2.54580284
58Premature ovarian failure (HP:0008209)2.52613075
59Abnormality of the prostate (HP:0008775)2.50332027
60Apathy (HP:0000741)2.48321123
61Restrictive lung disease (HP:0002091)2.44001030
62Abnormal delayed hypersensitivity skin test (HP:0002963)2.43572637
63Malnutrition (HP:0004395)2.40964627
64Truncal obesity (HP:0001956)2.40586132
65Leukopenia (HP:0001882)2.39035979
66Obstructive sleep apnea (HP:0002870)2.32241208
67Hypercortisolism (HP:0001578)2.30173146
68Infertility (HP:0000789)2.29262151
69Male infertility (HP:0003251)2.17144929
70Lower limb hyperreflexia (HP:0002395)2.16752750
71Encephalitis (HP:0002383)2.15018263
72* Lymphoma (HP:0002665)2.08022794
73IgM deficiency (HP:0002850)2.07078256
74Capillary hemangiomas (HP:0005306)2.06828697
75Aplasia/Hypoplasia of the macula (HP:0008059)2.03016308
76Limb hypertonia (HP:0002509)2.01674954
77Dehydration (HP:0001944)2.00155780
78Oligodactyly (hands) (HP:0001180)1.99247855
79Hypophosphatemic rickets (HP:0004912)1.98691526
80Prostate neoplasm (HP:0100787)1.97690807
81Recurrent skin infections (HP:0001581)1.95952824
82Azoospermia (HP:0000027)1.93992804
83Viral hepatitis (HP:0006562)1.92911057
84Increased IgM level (HP:0003496)1.90465766
85Combined immunodeficiency (HP:0005387)1.84751991
86Aplasia/Hypoplasia affecting the retina (HP:0008061)1.82814951
87Abnormality of the preputium (HP:0100587)1.81861005
88Abnormality of male internal genitalia (HP:0000022)1.80921530
89Gonadotropin excess (HP:0000837)1.80180038
90Chronic mucocutaneous candidiasis (HP:0002728)1.79940289
91Recurrent cutaneous fungal infections (HP:0011370)1.79940289
92Papillary thyroid carcinoma (HP:0002895)1.79869331
93Urticaria (HP:0001025)1.79333618
94Abnormality of chromosome stability (HP:0003220)1.78202618
95Carpal bone hypoplasia (HP:0001498)1.77200905
96Hypokinesia (HP:0002375)1.75742428
97Abnormal spermatogenesis (HP:0008669)1.74746133
98Abnormality of DNA repair (HP:0003254)1.72095827
99Increased IgE level (HP:0003212)1.71704978
100Secondary amenorrhea (HP:0000869)1.71004063

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K134.44138647
2ARAF3.83662813
3CDK123.54498818
4MAP3K93.38711785
5MAP3K103.20523921
6MAP4K13.12178371
7TESK22.72294330
8ERN12.59292598
9IRAK42.32094507
10RIPK42.17532763
11BRAF2.02984822
12STK241.96908552
13BLK1.96098894
14TAOK31.94211806
15SYK1.77270672
16TTK1.67803003
17TNK21.65363127
18AURKA1.58831246
19CDK91.58026917
20CDC71.54854776
21MST41.49874895
22NEK61.45518119
23PRPF4B1.41909575
24BMPR21.34712418
25MAPK111.32443709
26CDK191.31712839
27BTK1.29886094
28KSR21.27894067
29MELK1.27183975
30TLK11.25870350
31TYK21.24372447
32RAF11.23218617
33LYN1.21765956
34CDK71.19396622
35CSF1R1.16156442
36GRK61.15915952
37PIM11.15504638
38MAP3K81.12442669
39PRKCI1.11810253
40PKN11.08767993
41ZAK1.05882348
42NTRK21.03921901
43MARK31.02852991
44EEF2K1.02795900
45KIT0.97334909
46CDK40.95942028
47ACVR1B0.95089549
48CDK80.89857565
49EIF2AK30.88924934
50MAP3K140.87217727
51IKBKB0.84592163
52MOS0.84202988
53CHEK10.83814848
54MAPK120.81025455
55TAOK20.78730513
56PRKCQ0.77769180
57ZAP700.74728122
58BRSK10.73144277
59FES0.71306686
60PLK10.71282369
61IKBKE0.69879094
62ATR0.68445429
63STK100.65753872
64LCK0.65116706
65VRK10.64478007
66PASK0.63835764
67MAP2K30.62502369
68CDC42BPA0.61299138
69KDR0.61097162
70CDK20.60837960
71NEK90.59248411
72MARK20.54462656
73JAK30.54031438
74LRRK20.53707744
75STK30.53486042
76MAPK130.52577924
77BRD40.52332210
78TEC0.52157197
79PRKD20.51631350
80AURKB0.50576505
81TAOK10.49722289
82CSK0.48835414
83CHEK20.48518513
84HCK0.48448123
85NEK20.48177697
86ATM0.47255915
87PRKCZ0.46485018
88CLK10.45196458
89PDK10.44817822
90TBK10.43387691
91WNK10.43117810
92PAK10.42242513
93BUB10.41353455
94MAP3K10.41309290
95PRKD10.39068012
96MAP3K50.35652433
97CSNK1D0.35187535
98MET0.34459106
99FYN0.33791966
100CHUK0.33149696

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.05514316
2B cell receptor signaling pathway_Homo sapiens_hsa046623.80833709
3Intestinal immune network for IgA production_Homo sapiens_hsa046723.32875776
4Allograft rejection_Homo sapiens_hsa053303.28060710
5Asthma_Homo sapiens_hsa053103.16355715
6Autoimmune thyroid disease_Homo sapiens_hsa053203.12685192
7Graft-versus-host disease_Homo sapiens_hsa053322.88292960
8Mismatch repair_Homo sapiens_hsa034302.63583012
9Base excision repair_Homo sapiens_hsa034102.47910694
10DNA replication_Homo sapiens_hsa030302.42736438
11Type I diabetes mellitus_Homo sapiens_hsa049402.39534675
12Cell cycle_Homo sapiens_hsa041102.36678619
13Basal transcription factors_Homo sapiens_hsa030222.08008754
14Leishmaniasis_Homo sapiens_hsa051401.98614373
15Antigen processing and presentation_Homo sapiens_hsa046121.97037714
16Ovarian steroidogenesis_Homo sapiens_hsa049131.82589438
17Homologous recombination_Homo sapiens_hsa034401.80165430
18Herpes simplex infection_Homo sapiens_hsa051681.78021943
19Viral myocarditis_Homo sapiens_hsa054161.75648674
20Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.71034879
21Staphylococcus aureus infection_Homo sapiens_hsa051501.60721816
22Hematopoietic cell lineage_Homo sapiens_hsa046401.54103146
23Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.49950891
24Systemic lupus erythematosus_Homo sapiens_hsa053221.44467568
25Dorso-ventral axis formation_Homo sapiens_hsa043201.38720513
26Fanconi anemia pathway_Homo sapiens_hsa034601.38166760
27Osteoclast differentiation_Homo sapiens_hsa043801.35315182
28Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.34413250
29Oocyte meiosis_Homo sapiens_hsa041141.30558300
30Influenza A_Homo sapiens_hsa051641.26606675
31Non-homologous end-joining_Homo sapiens_hsa034501.26369553
32NF-kappa B signaling pathway_Homo sapiens_hsa040641.26013151
33Nucleotide excision repair_Homo sapiens_hsa034201.25963684
34Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.23187713
35Phosphatidylinositol signaling system_Homo sapiens_hsa040701.19928207
36RNA degradation_Homo sapiens_hsa030181.19889593
37Epstein-Barr virus infection_Homo sapiens_hsa051691.13748871
38HTLV-I infection_Homo sapiens_hsa051661.12058274
39Toxoplasmosis_Homo sapiens_hsa051451.12055270
40Viral carcinogenesis_Homo sapiens_hsa052031.08701244
41Tuberculosis_Homo sapiens_hsa051521.08615777
42T cell receptor signaling pathway_Homo sapiens_hsa046601.06372025
43Inositol phosphate metabolism_Homo sapiens_hsa005621.05778640
44Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.04277093
45p53 signaling pathway_Homo sapiens_hsa041151.02383556
46Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.01493605
47Toll-like receptor signaling pathway_Homo sapiens_hsa046200.97702192
48Phagosome_Homo sapiens_hsa041450.94203239
49Rheumatoid arthritis_Homo sapiens_hsa053230.91481044
50Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.90947956
51Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.85744905
52RNA transport_Homo sapiens_hsa030130.84777221
53mRNA surveillance pathway_Homo sapiens_hsa030150.84228931
54Measles_Homo sapiens_hsa051620.78345605
55Hepatitis B_Homo sapiens_hsa051610.77175923
56Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.77065766
57Non-small cell lung cancer_Homo sapiens_hsa052230.73839117
58Caffeine metabolism_Homo sapiens_hsa002320.72815589
59Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.71504001
60Acute myeloid leukemia_Homo sapiens_hsa052210.68626851
61Chemokine signaling pathway_Homo sapiens_hsa040620.68472061
62Shigellosis_Homo sapiens_hsa051310.57564665
63Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.57550396
64Cysteine and methionine metabolism_Homo sapiens_hsa002700.56373466
65RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.55567040
66mTOR signaling pathway_Homo sapiens_hsa041500.55419407
67FoxO signaling pathway_Homo sapiens_hsa040680.53806542
68Transcriptional misregulation in cancer_Homo sapiens_hsa052020.53153955
69Alcoholism_Homo sapiens_hsa050340.49965549
70Thyroid cancer_Homo sapiens_hsa052160.48488065
71Jak-STAT signaling pathway_Homo sapiens_hsa046300.47689401
72ABC transporters_Homo sapiens_hsa020100.47265281
73Olfactory transduction_Homo sapiens_hsa047400.45856156
74Apoptosis_Homo sapiens_hsa042100.43651541
75Sphingolipid signaling pathway_Homo sapiens_hsa040710.43640636
76Gap junction_Homo sapiens_hsa045400.41433944
77Pancreatic cancer_Homo sapiens_hsa052120.40107208
78SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37587961
79RNA polymerase_Homo sapiens_hsa030200.37385543
80Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.36586781
81Notch signaling pathway_Homo sapiens_hsa043300.36272712
82Chronic myeloid leukemia_Homo sapiens_hsa052200.35825963
83Renal cell carcinoma_Homo sapiens_hsa052110.33968802
84Glycosaminoglycan degradation_Homo sapiens_hsa005310.32623619
85Prostate cancer_Homo sapiens_hsa052150.32567436
86Phospholipase D signaling pathway_Homo sapiens_hsa040720.29789424
87Small cell lung cancer_Homo sapiens_hsa052220.28170210
88Neurotrophin signaling pathway_Homo sapiens_hsa047220.27785447
89TNF signaling pathway_Homo sapiens_hsa046680.27708500
90Lysine degradation_Homo sapiens_hsa003100.26193716
91Thyroid hormone signaling pathway_Homo sapiens_hsa049190.25106609
92Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.24171935
93African trypanosomiasis_Homo sapiens_hsa051430.22994620
94Folate biosynthesis_Homo sapiens_hsa007900.22771841
95Phototransduction_Homo sapiens_hsa047440.22687067
96Malaria_Homo sapiens_hsa051440.22255188
97Pyrimidine metabolism_Homo sapiens_hsa002400.21215059
98Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.20034714
99Endocytosis_Homo sapiens_hsa041440.19987771
100Colorectal cancer_Homo sapiens_hsa052100.19471714

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