TCL1B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic chromosome condensation (GO:0007076)6.21998415
2DNA unwinding involved in DNA replication (GO:0006268)6.11190764
3V(D)J recombination (GO:0033151)5.79491180
4DNA strand elongation involved in DNA replication (GO:0006271)5.68655295
5DNA strand elongation (GO:0022616)5.55673809
6DNA replication initiation (GO:0006270)5.26126561
7positive regulation of protein homooligomerization (GO:0032464)5.19370687
8B cell receptor signaling pathway (GO:0050853)5.04117777
9DNA topological change (GO:0006265)4.96345601
10telomere maintenance via semi-conservative replication (GO:0032201)4.89529996
11mitotic sister chromatid cohesion (GO:0007064)4.77747377
12meiotic chromosome segregation (GO:0045132)4.74260219
13regulation of histone H3-K9 methylation (GO:0051570)4.62028426
14mitotic sister chromatid segregation (GO:0000070)4.58268125
15protein localization to chromosome, centromeric region (GO:0071459)4.41313716
16sister chromatid segregation (GO:0000819)4.32844211
17DNA ligation (GO:0006266)4.32782142
18mitotic metaphase plate congression (GO:0007080)4.31124255
19somatic diversification of immune receptors via germline recombination within a single locus (GO:0004.24324477
20somatic cell DNA recombination (GO:0016444)4.24324477
21telomere maintenance via recombination (GO:0000722)4.22176345
22mitotic recombination (GO:0006312)4.08461195
23negative regulation of histone methylation (GO:0031061)4.06477323
24protein localization to kinetochore (GO:0034501)3.99741263
25establishment of integrated proviral latency (GO:0075713)3.95728961
26oocyte development (GO:0048599)3.94854046
27somatic diversification of immune receptors (GO:0002200)3.93304410
28positive regulation of chromosome segregation (GO:0051984)3.92124999
29somatic recombination of immunoglobulin gene segments (GO:0016447)3.86811739
30chromosome condensation (GO:0030261)3.84867926
31cellular hyperosmotic response (GO:0071474)3.78971710
32metaphase plate congression (GO:0051310)3.67968970
33DNA replication checkpoint (GO:0000076)3.66192685
34maturation of 5.8S rRNA (GO:0000460)3.61841843
35regulation of sister chromatid cohesion (GO:0007063)3.51581351
36establishment of chromosome localization (GO:0051303)3.50843029
37nucleotide-excision repair, DNA gap filling (GO:0006297)3.48504174
38somatic diversification of immunoglobulins (GO:0016445)3.48189270
39positive regulation of mitotic sister chromatid separation (GO:1901970)3.47600005
40positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.47600005
41positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.47600005
42positive regulation of B cell differentiation (GO:0045579)3.45604211
43nuclear pore complex assembly (GO:0051292)3.42589596
44telomere maintenance via telomere lengthening (GO:0010833)3.39388644
45mitotic nuclear envelope disassembly (GO:0007077)3.38184159
46somatic diversification of immune receptors via somatic mutation (GO:0002566)3.38106701
47somatic hypermutation of immunoglobulin genes (GO:0016446)3.38106701
48nuclear pore organization (GO:0006999)3.31198793
49kinetochore organization (GO:0051383)3.30555800
50regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.27872947
51protein localization to chromosome (GO:0034502)3.26801049
52regulation of DNA endoreduplication (GO:0032875)3.26535895
53chromosome segregation (GO:0007059)3.26020372
54positive regulation of developmental pigmentation (GO:0048087)3.22466464
55T cell lineage commitment (GO:0002360)3.21870426
56ATP-dependent chromatin remodeling (GO:0043044)3.21609826
57regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.21240091
58DNA packaging (GO:0006323)3.19079344
59regulation of protein heterodimerization activity (GO:0043497)3.14821215
60nuclear envelope disassembly (GO:0051081)3.14295983
61membrane disassembly (GO:0030397)3.14295983
62regulation of meiosis I (GO:0060631)3.13568384
63CENP-A containing nucleosome assembly (GO:0034080)3.13284668
64establishment of viral latency (GO:0019043)3.10308053
65positive regulation of histone H3-K4 methylation (GO:0051571)3.07518442
66ear development (GO:0043583)3.06237373
67DNA conformation change (GO:0071103)3.03796872
68chromatin remodeling at centromere (GO:0031055)3.02667900
69CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.01919806
70spindle assembly involved in mitosis (GO:0090307)3.01361628
71sister chromatid cohesion (GO:0007062)3.00049499
72spliceosomal tri-snRNP complex assembly (GO:0000244)2.99972777
73nucleosome disassembly (GO:0006337)2.99050847
74protein-DNA complex disassembly (GO:0032986)2.99050847
75piRNA metabolic process (GO:0034587)2.98365521
76base-excision repair (GO:0006284)2.95340041
77regulation of spindle checkpoint (GO:0090231)2.93432750
78positive regulation of protein oligomerization (GO:0032461)2.92233546
79regulation of histone methylation (GO:0031060)2.91908528
80B cell homeostasis (GO:0001782)2.91840289
81regulation of chromosome segregation (GO:0051983)2.87441805
82chromatin assembly or disassembly (GO:0006333)2.86314580
83non-recombinational repair (GO:0000726)2.85786467
84double-strand break repair via nonhomologous end joining (GO:0006303)2.85786467
85positive regulation by host of viral transcription (GO:0043923)2.84826088
86folic acid-containing compound biosynthetic process (GO:0009396)2.83967374
87microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.81963852
88synapsis (GO:0007129)2.81635215
89DNA duplex unwinding (GO:0032508)2.79489259
90somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.78778845
91somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.78778845
92isotype switching (GO:0045190)2.78778845
93mitotic cell cycle (GO:0000278)2.78342025
94B cell proliferation (GO:0042100)2.76790178
95short-chain fatty acid metabolic process (GO:0046459)2.76551465
96heterochromatin organization (GO:0070828)2.76266413
97telomere organization (GO:0032200)2.75061673
98telomere maintenance (GO:0000723)2.74903844
99spindle assembly (GO:0051225)2.74884337
100DNA replication-independent nucleosome organization (GO:0034724)2.73863631

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.30662701
2MYC_22102868_ChIP-Seq_BL_Human4.28489042
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.88144198
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.65311278
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.31320978
6MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.27076323
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.19340311
8HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.99120298
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.77681750
10E2F1_21310950_ChIP-Seq_MCF-7_Human2.47111363
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.46559088
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.34908375
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.31928149
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.31910617
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.31811201
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.27333293
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.24580121
18MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.22945310
19CIITA_25753668_ChIP-Seq_RAJI_Human2.22702408
20FOXP3_21729870_ChIP-Seq_TREG_Human2.18088078
21POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.03686869
22E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.02760046
23ETS1_20019798_ChIP-Seq_JURKAT_Human2.01658336
24THAP11_20581084_ChIP-Seq_MESCs_Mouse2.01372436
25E2F7_22180533_ChIP-Seq_HELA_Human10.5842333
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.97839967
27GABP_17652178_ChIP-ChIP_JURKAT_Human1.96552496
28NOTCH1_21737748_ChIP-Seq_TLL_Human1.84610465
29SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.83309962
30EGR1_19374776_ChIP-ChIP_THP-1_Human1.79883969
31NELFA_20434984_ChIP-Seq_ESCs_Mouse1.73263649
32SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.71911007
33YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.71853714
34MYCN_18555785_ChIP-Seq_MESCs_Mouse1.70626753
35PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.68481215
36NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.67012357
37KDM5A_27292631_Chip-Seq_BREAST_Human1.65772833
38KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.64331223
39HOXB4_20404135_ChIP-ChIP_EML_Mouse1.62740462
40MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.60815853
41DCP1A_22483619_ChIP-Seq_HELA_Human1.60669992
42XRN2_22483619_ChIP-Seq_HELA_Human1.58639629
43VDR_23849224_ChIP-Seq_CD4+_Human1.57478943
44STAT6_21828071_ChIP-Seq_BEAS2B_Human1.54596321
45GABP_19822575_ChIP-Seq_HepG2_Human1.53290960
46AR_21909140_ChIP-Seq_LNCAP_Human1.51562949
47NANOG_18555785_ChIP-Seq_MESCs_Mouse1.50762678
48TTF2_22483619_ChIP-Seq_HELA_Human1.45918445
49YY1_21170310_ChIP-Seq_MESCs_Mouse1.45631947
50E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.45242072
51PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.45023632
52SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.43992468
53CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.42835613
54E2F1_18555785_ChIP-Seq_MESCs_Mouse1.37989339
55TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.36127841
56VDR_21846776_ChIP-Seq_THP-1_Human1.35655374
57ELF1_17652178_ChIP-ChIP_JURKAT_Human1.34453670
58FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.33722292
59CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.33344726
60ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.30660555
61IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.28961997
62TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.27493496
63ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.27154551
64ZFX_18555785_ChIP-Seq_MESCs_Mouse1.25017686
65EZH2_22144423_ChIP-Seq_EOC_Human1.23154892
66ERG_20887958_ChIP-Seq_HPC-7_Mouse1.23141440
67SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.22195075
68CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.21487013
69CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.15501906
70BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.13467380
71DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.05953873
72POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.05096787
73KLF4_18555785_ChIP-Seq_MESCs_Mouse1.04832036
74MYB_26560356_Chip-Seq_TH2_Human0.99337072
75CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.99121873
76SRF_21415370_ChIP-Seq_HL-1_Mouse0.98021464
77MYB_26560356_Chip-Seq_TH1_Human0.97940126
78PADI4_21655091_ChIP-ChIP_MCF-7_Human0.96910299
79HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.96831648
80TFEB_21752829_ChIP-Seq_HELA_Human0.96060965
81GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.94667416
82PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.93039601
83TP63_19390658_ChIP-ChIP_HaCaT_Human0.92188877
84RBPJ_22232070_ChIP-Seq_NCS_Mouse0.90957792
85SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.90826107
86TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90012390
87FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.87475291
88CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.86477547
89IRF8_22096565_ChIP-ChIP_GC-B_Human0.85007924
90SOX2_18555785_ChIP-Seq_MESCs_Mouse0.82619384
91UTX_26944678_Chip-Seq_JUKART_Human0.82571605
92SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.81532917
93ELK1_19687146_ChIP-ChIP_HELA_Human0.78519938
94TBX5_21415370_ChIP-Seq_HL-1_Mouse0.77483876
95PU.1_20513432_ChIP-Seq_Bcells_Mouse0.74859716
96KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.74135636
97POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.73143262
98MYC_18940864_ChIP-ChIP_HL60_Human0.72862435
99SPI1_23547873_ChIP-Seq_NB4_Human0.71934081
100P300_27268052_Chip-Seq_Bcells_Human0.71633739

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability5.17971574
2MP0001986_abnormal_taste_sensitivity4.97352737
3MP0003693_abnormal_embryo_hatching4.73837975
4MP0005423_abnormal_somatic_nervous4.44303196
5MP0008057_abnormal_DNA_replication4.20567297
6MP0003111_abnormal_nucleus_morphology4.09331253
7MP0008058_abnormal_DNA_repair3.79482224
8MP0003077_abnormal_cell_cycle3.63795238
9MP0004957_abnormal_blastocyst_morpholog3.53183864
10MP0000372_irregular_coat_pigmentation2.68352180
11MP0003763_abnormal_thymus_physiology2.63119889
12MP0005075_abnormal_melanosome_morpholog2.51044071
13MP0003718_maternal_effect2.31817599
14MP0008932_abnormal_embryonic_tissue2.31789517
15MP0002396_abnormal_hematopoietic_system2.18853417
16MP0001730_embryonic_growth_arrest2.12532015
17MP0010307_abnormal_tumor_latency2.07206820
18MP0004381_abnormal_hair_follicle2.05952485
19MP0005076_abnormal_cell_differentiation1.98685606
20MP0008877_abnormal_DNA_methylation1.97613397
21MP0000350_abnormal_cell_proliferation1.92157197
22MP0000685_abnormal_immune_system1.87040137
23MP0000490_abnormal_crypts_of1.84149725
24MP0008007_abnormal_cellular_replicative1.83531855
25MP0001800_abnormal_humoral_immune1.53127121
26MP0004808_abnormal_hematopoietic_stem1.50432032
27MP0002019_abnormal_tumor_incidence1.50154138
28MP0001790_abnormal_immune_system1.50069966
29MP0005387_immune_system_phenotype1.50069966
30MP0000689_abnormal_spleen_morphology1.48073258
31MP0000703_abnormal_thymus_morphology1.47367712
32MP0002398_abnormal_bone_marrow1.47205174
33MP0001929_abnormal_gametogenesis1.46010207
34MP0002210_abnormal_sex_determination1.45112246
35MP0009333_abnormal_splenocyte_physiolog1.44180898
36MP0000313_abnormal_cell_death1.39201396
37MP0004233_abnormal_muscle_weight1.37167371
38MP0002722_abnormal_immune_system1.32346659
39MP0005380_embryogenesis_phenotype1.30949503
40MP0001672_abnormal_embryogenesis/_devel1.30949503
41MP0002009_preneoplasia1.30689273
42MP0010352_gastrointestinal_tract_polyps1.30553122
43MP0001835_abnormal_antigen_presentation1.23614589
44MP0000465_gastrointestinal_hemorrhage1.17361370
45MP0002452_abnormal_antigen_presenting1.17281282
46MP0006292_abnormal_olfactory_placode1.15757752
47MP0002080_prenatal_lethality1.14337368
48MP0005266_abnormal_metabolism1.13941811
49MP0003786_premature_aging1.08228015
50MP0001145_abnormal_male_reproductive1.06566072
51MP0003646_muscle_fatigue1.06022859
52MP0000716_abnormal_immune_system1.05102350
53MP0005645_abnormal_hypothalamus_physiol1.04442248
54MP0004185_abnormal_adipocyte_glucose1.02666231
55MP0001853_heart_inflammation1.01636633
56MP0005501_abnormal_skin_physiology1.01558481
57MP0000653_abnormal_sex_gland1.01280267
58MP0000015_abnormal_ear_pigmentation1.01164656
59MP0001697_abnormal_embryo_size1.00906038
60MP0003984_embryonic_growth_retardation0.99004249
61MP0005000_abnormal_immune_tolerance0.95353458
62MP0002420_abnormal_adaptive_immunity0.95250960
63MP0002751_abnormal_autonomic_nervous0.95008585
64MP0002132_abnormal_respiratory_system0.94405393
65MP0002088_abnormal_embryonic_growth/wei0.94078800
66MP0006035_abnormal_mitochondrial_morpho0.93741288
67MP0002429_abnormal_blood_cell0.92600160
68MP0003699_abnormal_female_reproductive0.92259210
69MP0003890_abnormal_embryonic-extraembry0.91709947
70MP0002166_altered_tumor_susceptibility0.90873075
71MP0001819_abnormal_immune_cell0.90110476
72MP0005310_abnormal_salivary_gland0.87978821
73MP0002085_abnormal_embryonic_tissue0.85193292
74MP0002723_abnormal_immune_serum0.82752986
75MP0006036_abnormal_mitochondrial_physio0.81327276
76MP0003698_abnormal_male_reproductive0.80996396
77MP0001873_stomach_inflammation0.80843546
78MP0005379_endocrine/exocrine_gland_phen0.77545621
79MP0001119_abnormal_female_reproductive0.76919139
80MP0002138_abnormal_hepatobiliary_system0.76518301
81MP0002161_abnormal_fertility/fecundity0.76002208
82MP0002006_tumorigenesis0.75860691
83MP0009672_abnormal_birth_weight0.75091181
84MP0005395_other_phenotype0.74235012
85MP0002822_catalepsy0.72371644
86MP0005621_abnormal_cell_physiology0.67868434
87MP0002084_abnormal_developmental_patter0.67741304
88MP0002163_abnormal_gland_morphology0.67734862
89MP0002405_respiratory_system_inflammati0.67722726
90MP0005408_hypopigmentation0.64651332
91MP0000377_abnormal_hair_follicle0.64629950
92MP0002086_abnormal_extraembryonic_tissu0.63969421
93MP0003959_abnormal_lean_body0.63282875
94MP0003303_peritoneal_inflammation0.62618073
95MP0005384_cellular_phenotype0.62282802
96MP0005389_reproductive_system_phenotype0.62009040
97MP0002160_abnormal_reproductive_system0.61492109
98MP0002332_abnormal_exercise_endurance0.57103926
99MP0000358_abnormal_cell_content/0.55757801
100MP0001661_extended_life_span0.55046125

Predicted human phenotypes

RankGene SetZ-score
1Agammaglobulinemia (HP:0004432)6.61779496
2B lymphocytopenia (HP:0010976)5.11405844
3Chromosomal breakage induced by crosslinking agents (HP:0003221)4.85060580
4Panhypogammaglobulinemia (HP:0003139)4.74603846
5Chromsome breakage (HP:0040012)4.38997354
6Abnormality of B cell number (HP:0010975)4.32722992
7Cellulitis (HP:0100658)4.19874019
8Papilloma (HP:0012740)4.06910291
9Verrucae (HP:0200043)4.06910291
10Poikiloderma (HP:0001029)4.02143965
11Medulloblastoma (HP:0002885)3.78101140
12Meningitis (HP:0001287)3.54719974
13Recurrent bronchitis (HP:0002837)3.41768292
14Combined immunodeficiency (HP:0005387)3.40156446
15Chronic sinusitis (HP:0011109)3.33872965
16Hypoplasia of the thymus (HP:0000778)3.29996420
17Osteomyelitis (HP:0002754)3.23758312
18Severe combined immunodeficiency (HP:0004430)3.05626988
19Abnormality of chromosome stability (HP:0003220)3.00673771
20Ependymoma (HP:0002888)2.95501198
21Aplasia/Hypoplasia of the uvula (HP:0010293)2.92631983
22Volvulus (HP:0002580)2.91282401
23Increased nuchal translucency (HP:0010880)2.90696253
24Abnormality of the preputium (HP:0100587)2.87289202
25Meckel diverticulum (HP:0002245)2.86041024
26Carpal bone hypoplasia (HP:0001498)2.84456223
27Microvesicular hepatic steatosis (HP:0001414)2.77182517
28Abnormality of the ileum (HP:0001549)2.74992504
29Abnormality of DNA repair (HP:0003254)2.73191665
30Recurrent viral infections (HP:0004429)2.71613516
31Birth length less than 3rd percentile (HP:0003561)2.71549758
32Lymphoma (HP:0002665)2.67682307
33Abnormality of the renal collecting system (HP:0004742)2.67539168
34Duplicated collecting system (HP:0000081)2.64123274
35Reticulocytopenia (HP:0001896)2.61165267
36Abnormality of the carotid arteries (HP:0005344)2.61037495
37Rhabdomyosarcoma (HP:0002859)2.60697216
38Colitis (HP:0002583)2.60481871
39Small intestinal stenosis (HP:0012848)2.59825901
40Duodenal stenosis (HP:0100867)2.59825901
41Sepsis (HP:0100806)2.57546978
42External ear malformation (HP:0008572)2.52715873
43Impulsivity (HP:0100710)2.51922829
44Horseshoe kidney (HP:0000085)2.50670229
45Aplasia/Hypoplasia of the thymus (HP:0010515)2.42060621
46Patellar aplasia (HP:0006443)2.41718185
47Glioma (HP:0009733)2.39613634
48Ectopic kidney (HP:0000086)2.39562110
49Colon cancer (HP:0003003)2.34912021
50IgM deficiency (HP:0002850)2.34367705
51Neoplasm of the adrenal cortex (HP:0100641)2.30874580
52Recurrent otitis media (HP:0000403)2.29360403
53Astrocytoma (HP:0009592)2.27444909
54Abnormality of the astrocytes (HP:0100707)2.27444909
55Squamous cell carcinoma (HP:0002860)2.27131636
56Gastrointestinal inflammation (HP:0004386)2.26315956
57Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.24569404
58Thyroiditis (HP:0100646)2.22398677
59Aplasia/Hypoplasia of the patella (HP:0006498)2.21961270
60Hypercortisolism (HP:0001578)2.19855337
61Clubbing of toes (HP:0100760)2.19625003
62Ankyloglossia (HP:0010296)2.19127351
63Neoplasm of striated muscle (HP:0009728)2.18825240
64Premature ovarian failure (HP:0008209)2.17335663
65Basal cell carcinoma (HP:0002671)2.14392575
66Abnormality of the duodenum (HP:0002246)2.13616783
67IgG deficiency (HP:0004315)2.11791414
68Agnosia (HP:0010524)2.11130983
69Cafe-au-lait spot (HP:0000957)2.08813561
70Progressive external ophthalmoplegia (HP:0000590)2.07538488
71Deep palmar crease (HP:0006191)2.06685108
72Adenoma sebaceum (HP:0009720)2.06509033
73Angiofibromas (HP:0010615)2.06509033
74Recurrent pneumonia (HP:0006532)2.05702387
75Recurrent lower respiratory tract infections (HP:0002783)2.04753840
76Absent thumb (HP:0009777)2.02600075
77Bronchitis (HP:0012387)2.01800230
78Gastrointestinal carcinoma (HP:0002672)2.00862146
79Malignant gastrointestinal tract tumors (HP:0006749)2.00862146
80T lymphocytopenia (HP:0005403)1.98930708
81Recurrent sinusitis (HP:0011108)1.96873408
82Sloping forehead (HP:0000340)1.95511349
83Myelodysplasia (HP:0002863)1.93177181
84Proximal placement of thumb (HP:0009623)1.92523298
85Uterine leiomyosarcoma (HP:0002891)1.92085871
86Leiomyosarcoma (HP:0100243)1.92085871
87Obsessive-compulsive behavior (HP:0000722)1.90717510
88Abnormality of abdominal situs (HP:0011620)1.89283021
89Abdominal situs inversus (HP:0003363)1.89283021
90Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.89134376
91Hypergonadotropic hypogonadism (HP:0000815)1.87913112
92Nephroblastoma (Wilms tumor) (HP:0002667)1.87276587
93Inflammation of the large intestine (HP:0002037)1.86952970
94Absent radius (HP:0003974)1.86882414
95Short thumb (HP:0009778)1.85376840
96Acute lymphatic leukemia (HP:0006721)1.84645406
97Prominent nose (HP:0000448)1.81737993
98Mediastinal lymphadenopathy (HP:0100721)1.81327338
99Abnormality of the thymus (HP:0000777)1.81108229
100Viral hepatitis (HP:0006562)1.80860780

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K108.61476437
2ERN13.70035978
3VRK23.12978390
4CDC73.07522887
5CDK83.00014859
6ICK2.88626579
7SMG12.77102040
8BUB12.45590643
9TESK22.35962096
10CDK42.25921341
11MAP4K12.01699277
12TTK1.99025764
13PRPF4B1.98428019
14MST41.64520230
15SRPK11.58181243
16MELK1.51485351
17BLK1.49202486
18CDK71.40810920
19ATR1.40053325
20CDK121.39353041
21TAF11.38085782
22CDK91.35853131
23BRSK11.23911713
24EEF2K1.22384907
25CHEK21.18926981
26TRIB31.17364797
27CHEK11.16396088
28TESK11.13444048
29BMPR1B1.12443534
30PLK11.12338831
31PRKCI1.11434399
32AURKA1.09340039
33BRSK21.08583500
34WEE11.07805118
35MAPK111.07624600
36PBK1.04990728
37PLK41.00437273
38STK100.98073210
39MAP3K90.95229783
40TGFBR10.94877081
41EIF2AK30.93336206
42MAP3K80.91513468
43ZAK0.90306267
44AURKB0.88357510
45VRK10.87979415
46SYK0.80747562
47RPS6KB20.80380116
48ACVR1B0.80123407
49PLK30.76436132
50CDK20.74633830
51ATM0.73519776
52NLK0.71188020
53MAPK40.69913358
54LYN0.63740999
55STK160.63158733
56RPS6KB10.61676244
57FES0.61431781
58PIM10.61057795
59MAP3K130.59640972
60CDK10.59020640
61NEK20.58323243
62MARK30.56969383
63LRRK20.54963161
64RPS6KC10.52480327
65RPS6KL10.52480327
66BTK0.52343261
67TNK20.50856502
68STK240.49479266
69RAF10.48549451
70ARAF0.47175011
71KSR20.46833153
72CCNB10.46658400
73CAMK1D0.46476370
74TRIM280.46072745
75BRAF0.45940157
76MAPKAPK20.43230293
77NUAK10.43158538
78RPS6KA60.42894275
79AKT20.37245315
80MAPK90.35926371
81CSNK2A20.34192124
82NEK10.33528150
83SCYL20.33168226
84CSNK2A10.33083746
85CDK190.32628026
86TLK10.31762582
87MAP2K20.31111715
88MTOR0.30479406
89CSNK1G10.29973388
90MAPK140.29609805
91RPS6KA10.28897145
92MAPK10.28321730
93PAK10.27759149
94GSK3B0.27700480
95CAMK1G0.27131952
96MAPK70.26858802
97DAPK10.26293178
98TSSK60.25877158
99MAPK30.25696597
100EIF2AK20.24255869

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030306.10268155
2Mismatch repair_Homo sapiens_hsa034304.55005247
3Base excision repair_Homo sapiens_hsa034103.98722538
4Cell cycle_Homo sapiens_hsa041103.54319526
5Homologous recombination_Homo sapiens_hsa034403.13876240
6Non-homologous end-joining_Homo sapiens_hsa034503.11487500
7B cell receptor signaling pathway_Homo sapiens_hsa046622.66964114
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.58904717
9Fanconi anemia pathway_Homo sapiens_hsa034602.51732070
10Nucleotide excision repair_Homo sapiens_hsa034202.49655071
11Primary immunodeficiency_Homo sapiens_hsa053402.40784071
12Spliceosome_Homo sapiens_hsa030402.39151431
13RNA transport_Homo sapiens_hsa030132.32251350
14One carbon pool by folate_Homo sapiens_hsa006702.27622052
15RNA polymerase_Homo sapiens_hsa030202.27079462
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.23679487
17Proteasome_Homo sapiens_hsa030502.21281416
18Basal transcription factors_Homo sapiens_hsa030222.04580990
19mRNA surveillance pathway_Homo sapiens_hsa030151.96155677
20Pyrimidine metabolism_Homo sapiens_hsa002401.74344579
21RNA degradation_Homo sapiens_hsa030181.73703242
22Cyanoamino acid metabolism_Homo sapiens_hsa004601.41805891
23Ribosome_Homo sapiens_hsa030101.37597152
24Oocyte meiosis_Homo sapiens_hsa041141.36649155
25Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.22558551
26Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.20168648
27p53 signaling pathway_Homo sapiens_hsa041151.19611442
28MicroRNAs in cancer_Homo sapiens_hsa052061.01361845
29Prostate cancer_Homo sapiens_hsa052150.99668039
30Epstein-Barr virus infection_Homo sapiens_hsa051690.98359292
31Notch signaling pathway_Homo sapiens_hsa043300.97971355
32Colorectal cancer_Homo sapiens_hsa052100.95167917
33Apoptosis_Homo sapiens_hsa042100.92123339
34Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.88645359
35Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.85792275
36Purine metabolism_Homo sapiens_hsa002300.85231098
37Folate biosynthesis_Homo sapiens_hsa007900.83373568
38Vitamin B6 metabolism_Homo sapiens_hsa007500.83093848
39Hepatitis B_Homo sapiens_hsa051610.82000147
40Cysteine and methionine metabolism_Homo sapiens_hsa002700.81880855
41Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.80360136
42Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.80013860
43Sulfur relay system_Homo sapiens_hsa041220.78183423
44Chronic myeloid leukemia_Homo sapiens_hsa052200.76432768
45HTLV-I infection_Homo sapiens_hsa051660.74321337
46Non-small cell lung cancer_Homo sapiens_hsa052230.73769107
472-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.68281584
48Butanoate metabolism_Homo sapiens_hsa006500.67477856
49Viral carcinogenesis_Homo sapiens_hsa052030.64601379
50NF-kappa B signaling pathway_Homo sapiens_hsa040640.62994226
51Herpes simplex infection_Homo sapiens_hsa051680.62217634
52Small cell lung cancer_Homo sapiens_hsa052220.61643706
53mTOR signaling pathway_Homo sapiens_hsa041500.59602486
54Selenocompound metabolism_Homo sapiens_hsa004500.59407840
55Steroid biosynthesis_Homo sapiens_hsa001000.55730200
56Bladder cancer_Homo sapiens_hsa052190.55399955
57Biosynthesis of amino acids_Homo sapiens_hsa012300.52413031
58Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.50810322
59Huntingtons disease_Homo sapiens_hsa050160.49826815
60Lysine degradation_Homo sapiens_hsa003100.48748926
61Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.48044320
62FoxO signaling pathway_Homo sapiens_hsa040680.47547025
63TGF-beta signaling pathway_Homo sapiens_hsa043500.47477401
64Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.43922455
65Pancreatic cancer_Homo sapiens_hsa052120.43612440
66Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.42508711
67Carbon metabolism_Homo sapiens_hsa012000.42077664
68AMPK signaling pathway_Homo sapiens_hsa041520.41264473
69Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41074669
70Propanoate metabolism_Homo sapiens_hsa006400.40456250
71Regulation of autophagy_Homo sapiens_hsa041400.40037250
72Parkinsons disease_Homo sapiens_hsa050120.39077436
73Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.37259766
74Transcriptional misregulation in cancer_Homo sapiens_hsa052020.35989418
75Olfactory transduction_Homo sapiens_hsa047400.35722261
76Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.34890981
77Glioma_Homo sapiens_hsa052140.33643391
78Melanoma_Homo sapiens_hsa052180.32115390
79Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.31445434
80Pentose phosphate pathway_Homo sapiens_hsa000300.27149018
81N-Glycan biosynthesis_Homo sapiens_hsa005100.26669522
82Endometrial cancer_Homo sapiens_hsa052130.24802966
83Thyroid hormone signaling pathway_Homo sapiens_hsa049190.24370928
84Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.23671685
85Dorso-ventral axis formation_Homo sapiens_hsa043200.23139394
86Insulin signaling pathway_Homo sapiens_hsa049100.23003909
87Neurotrophin signaling pathway_Homo sapiens_hsa047220.22529971
88T cell receptor signaling pathway_Homo sapiens_hsa046600.22486714
89Inositol phosphate metabolism_Homo sapiens_hsa005620.21620581
90Pyruvate metabolism_Homo sapiens_hsa006200.20200297
91Thyroid cancer_Homo sapiens_hsa052160.19666346
92HIF-1 signaling pathway_Homo sapiens_hsa040660.19631227
93Acute myeloid leukemia_Homo sapiens_hsa052210.18945264
94Renal cell carcinoma_Homo sapiens_hsa052110.18494593
95Shigellosis_Homo sapiens_hsa051310.13064807
96Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.11194595
97* PI3K-Akt signaling pathway_Homo sapiens_hsa041510.10337491
98Phosphatidylinositol signaling system_Homo sapiens_hsa040700.09865970
99Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.09198995
100Central carbon metabolism in cancer_Homo sapiens_hsa052300.08223598

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