TCN2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the vitamin B12-binding protein family. This family of proteins, alternatively referred to as R binders, is expressed in various tissues and secretions. This plasma protein binds cobalamin and mediates the transport of cobalamin into cells. This protein and other mammalian cobalamin-binding proteins, such as transcobalamin I and gastric intrisic factor, may have evolved by duplication of a common ancestral gene. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1drug transmembrane transport (GO:0006855)6.74383272
2urate metabolic process (GO:0046415)6.68604328
3angiotensin maturation (GO:0002003)6.36023393
4lysine metabolic process (GO:0006553)6.18748119
5lysine catabolic process (GO:0006554)6.18748119
6glycosphingolipid catabolic process (GO:0046479)6.16713941
7drug transport (GO:0015893)5.81724818
8glycolipid catabolic process (GO:0019377)5.73966525
9glyoxylate metabolic process (GO:0046487)5.73620302
10cysteine metabolic process (GO:0006534)5.45714031
11fat-soluble vitamin biosynthetic process (GO:0042362)5.41584845
12aminoglycoside antibiotic metabolic process (GO:0030647)5.40421274
13erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.25684265
14L-phenylalanine catabolic process (GO:0006559)5.25684265
15erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.21169018
16L-phenylalanine metabolic process (GO:0006558)5.21169018
17oligosaccharide catabolic process (GO:0009313)5.11487469
18drug catabolic process (GO:0042737)5.01310974
19organic cation transport (GO:0015695)4.99570802
20ceramide catabolic process (GO:0046514)4.91617550
21aromatic amino acid family catabolic process (GO:0009074)4.90672044
22fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.83578516
23adhesion of symbiont to host cell (GO:0044650)4.80930523
24virion attachment to host cell (GO:0019062)4.80930523
25exogenous drug catabolic process (GO:0042738)4.66892235
26phosphate ion transport (GO:0006817)4.62365358
27response to mercury ion (GO:0046689)4.61591293
28indole-containing compound catabolic process (GO:0042436)4.56363485
29indolalkylamine catabolic process (GO:0046218)4.56363485
30tryptophan catabolic process (GO:0006569)4.56363485
31homocysteine metabolic process (GO:0050667)4.49125057
32short-chain fatty acid metabolic process (GO:0046459)4.47021619
33tricarboxylic acid metabolic process (GO:0072350)4.39659935
34sphingolipid catabolic process (GO:0030149)4.38720528
35tryptophan metabolic process (GO:0006568)4.36692752
36quaternary ammonium group transport (GO:0015697)4.36288464
37regulation of mononuclear cell migration (GO:0071675)4.35821327
38valine metabolic process (GO:0006573)4.34011106
39membrane lipid catabolic process (GO:0046466)4.29834813
40sulfur amino acid catabolic process (GO:0000098)4.26566867
41amino-acid betaine metabolic process (GO:0006577)4.20672141
42cellular modified amino acid catabolic process (GO:0042219)4.18482852
43regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.16386747
44aspartate family amino acid catabolic process (GO:0009068)4.12628604
45adhesion of symbiont to host (GO:0044406)4.11957067
46serine family amino acid catabolic process (GO:0009071)4.10733535
47branched-chain amino acid metabolic process (GO:0009081)4.02265917
48phosphate ion transmembrane transport (GO:0035435)4.02264342
49fatty acid beta-oxidation (GO:0006635)3.96828289
50kynurenine metabolic process (GO:0070189)3.95098594
51vitamin D metabolic process (GO:0042359)3.94960842
522-oxoglutarate metabolic process (GO:0006103)3.93431220
53amino sugar catabolic process (GO:0046348)3.83179515
54fatty acid oxidation (GO:0019395)3.82113217
55peptide catabolic process (GO:0043171)3.80080482
56lipid oxidation (GO:0034440)3.77106522
57alpha-linolenic acid metabolic process (GO:0036109)3.73379862
58regulation of vitamin metabolic process (GO:0030656)3.64794574
59serine family amino acid metabolic process (GO:0009069)3.63278687
60carnitine metabolic process (GO:0009437)3.61725382
61regulation of cytokine secretion involved in immune response (GO:0002739)3.59025622
62aromatic amino acid family metabolic process (GO:0009072)3.57442930
63renal absorption (GO:0070293)3.57334253
64immunoglobulin mediated immune response (GO:0016064)3.55188147
65branched-chain amino acid catabolic process (GO:0009083)3.53071103
66cellular ketone body metabolic process (GO:0046950)3.52861686
67alpha-amino acid catabolic process (GO:1901606)3.52098845
68cellular amino acid catabolic process (GO:0009063)3.52075783
69acetyl-CoA metabolic process (GO:0006084)3.50315425
70excretion (GO:0007588)3.48824286
71fatty acid catabolic process (GO:0009062)3.47914494
72toxin transport (GO:1901998)3.46245492
73amino-acid betaine transport (GO:0015838)3.46224485
74carnitine transport (GO:0015879)3.46224485
75bile acid biosynthetic process (GO:0006699)3.45192481
76T-helper 1 type immune response (GO:0042088)3.43681322
77flavonoid metabolic process (GO:0009812)3.43371736
78lipoprotein transport (GO:0042953)3.43320117
79NADH metabolic process (GO:0006734)3.41835957
80fructose metabolic process (GO:0006000)3.40959800
81glutamate metabolic process (GO:0006536)3.38340606
82monocarboxylic acid catabolic process (GO:0072329)3.33891723
83regulation of cellular extravasation (GO:0002691)3.32918569
84benzene-containing compound metabolic process (GO:0042537)3.30753643
85carboxylic acid catabolic process (GO:0046395)3.29323813
86organic acid catabolic process (GO:0016054)3.29323813
87nonribosomal peptide biosynthetic process (GO:0019184)3.29122332
88branching involved in labyrinthine layer morphogenesis (GO:0060670)3.28131563
89barbed-end actin filament capping (GO:0051016)3.27881375
90drug metabolic process (GO:0017144)3.27589131
91proline metabolic process (GO:0006560)3.27217208
92regulation of fever generation (GO:0031620)3.26302687
93modified amino acid transport (GO:0072337)3.23090949
94eosinophil chemotaxis (GO:0048245)3.22178683
95regulation of cholesterol esterification (GO:0010872)3.21536132
96regulation of cholesterol homeostasis (GO:2000188)3.19974433
97negative regulation of interleukin-12 production (GO:0032695)3.19902517
98ethanol oxidation (GO:0006069)3.19439477
99biotin metabolic process (GO:0006768)3.19088890
100response to growth hormone (GO:0060416)3.17339026
101indolalkylamine metabolic process (GO:0006586)3.16941315
102regulation of podosome assembly (GO:0071801)3.16657387
103regulation of cholesterol storage (GO:0010885)3.16259569
104monocyte chemotaxis (GO:0002548)3.15884070
105urea cycle (GO:0000050)3.14875659
106urea metabolic process (GO:0019627)3.14875659
107cellular glucuronidation (GO:0052695)3.14222228
108regulation of guanylate cyclase activity (GO:0031282)3.13729033
109glucuronate metabolic process (GO:0019585)3.13653165
110uronic acid metabolic process (GO:0006063)3.13653165
111serine family amino acid biosynthetic process (GO:0009070)3.13511906
112phosphate ion homeostasis (GO:0055062)3.13141138
113trivalent inorganic anion homeostasis (GO:0072506)3.13141138
114glycosylceramide metabolic process (GO:0006677)3.11738483
115phospholipid efflux (GO:0033700)3.09662822
116regulation of dendritic cell antigen processing and presentation (GO:0002604)3.08654673
117ketone body metabolic process (GO:1902224)3.07568363
118protein carboxylation (GO:0018214)3.06606900
119peptidyl-glutamic acid carboxylation (GO:0017187)3.06606900
120response to phenylpropanoid (GO:0080184)3.04026903
121complement activation, alternative pathway (GO:0006957)3.03593572
122glutathione biosynthetic process (GO:0006750)3.02109376
123cyclooxygenase pathway (GO:0019371)3.01723344
124vitamin biosynthetic process (GO:0009110)3.01706243
125aldehyde catabolic process (GO:0046185)3.00969346
126tyrosine metabolic process (GO:0006570)3.00441850
127positive regulation of antigen processing and presentation (GO:0002579)2.99094010
128cellular biogenic amine catabolic process (GO:0042402)2.98488441
129amine catabolic process (GO:0009310)2.98488441
130nitrogen cycle metabolic process (GO:0071941)2.97994972
131positive regulation of heat generation (GO:0031652)2.97544039
132regulation of macrophage chemotaxis (GO:0010758)2.95467786
133cellular response to thyroid hormone stimulus (GO:0097067)2.94677208
134triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.94329399
135sodium-independent organic anion transport (GO:0043252)2.93230471
136eosinophil migration (GO:0072677)2.93220059
137regulation of vitamin D biosynthetic process (GO:0060556)2.92608272
138NADP metabolic process (GO:0006739)2.91467024
139response to peptidoglycan (GO:0032494)2.90661736
1404-hydroxyproline metabolic process (GO:0019471)2.88496164
141L-ascorbic acid metabolic process (GO:0019852)2.88063671
142positive regulation of triglyceride lipase activity (GO:0061365)2.87816906
143positive regulation of lipoprotein lipase activity (GO:0051006)2.87816906
144bile acid metabolic process (GO:0008206)2.87679940
145regulation of antigen processing and presentation (GO:0002577)2.85202707
146transcytosis (GO:0045056)2.83791230
147epoxygenase P450 pathway (GO:0019373)2.83005050
148small molecule catabolic process (GO:0044282)2.82651264
149interferon-gamma-mediated signaling pathway (GO:0060333)2.82259989
150myeloid dendritic cell differentiation (GO:0043011)2.82119539
151glycoside metabolic process (GO:0016137)2.79949469
152neutrophil activation involved in immune response (GO:0002283)2.77041112
153NIK/NF-kappaB signaling (GO:0038061)2.75114191
154positive regulation of chemokine biosynthetic process (GO:0045080)2.74017708
155negative regulation of nitric oxide biosynthetic process (GO:0045019)2.73050978
156keratan sulfate catabolic process (GO:0042340)2.70816142
157fat-soluble vitamin metabolic process (GO:0006775)2.70010270
158cellular response to type I interferon (GO:0071357)2.69859911
159type I interferon signaling pathway (GO:0060337)2.69859911
160B cell mediated immunity (GO:0019724)2.65613010
161macrophage activation involved in immune response (GO:0002281)2.65560304
162N-acetylneuraminate metabolic process (GO:0006054)2.64351404
163response to type I interferon (GO:0034340)2.63542518
164positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.62092181
165plasma lipoprotein particle assembly (GO:0034377)2.61035852
166detection of other organism (GO:0098543)2.57952247
167negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.57559665
168regulation of systemic arterial blood pressure by hormone (GO:0001990)2.56998042
169regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.56998042
170endocrine process (GO:0050886)2.56998042
171negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.54091701
172lipoprotein metabolic process (GO:0042157)2.53194009
173regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.52165393
174positive regulation of Cdc42 GTPase activity (GO:0043089)2.51693055
175regulation of monocyte chemotaxis (GO:0090025)2.49791689
176amyloid precursor protein catabolic process (GO:0042987)2.49579772
177positive regulation of cellular amide metabolic process (GO:0034250)2.48562807
178positive regulation of monocyte chemotaxis (GO:0090026)2.47581069
179regulation of membrane protein ectodomain proteolysis (GO:0051043)2.46723274
180protein-lipid complex assembly (GO:0065005)2.46229618
181response to interferon-beta (GO:0035456)2.45576962
182apoptotic cell clearance (GO:0043277)2.45093531
183positive regulation of pseudopodium assembly (GO:0031274)2.44059232
184cellular response to interferon-gamma (GO:0071346)2.44035629
185regulation of chemokine biosynthetic process (GO:0045073)2.43558696
186diacylglycerol metabolic process (GO:0046339)2.43508641
187very-low-density lipoprotein particle assembly (GO:0034379)2.43376659
188lipopolysaccharide-mediated signaling pathway (GO:0031663)2.43194577
189regulation of heat generation (GO:0031650)2.42782746
190detection of bacterium (GO:0016045)2.42220444
191intestinal absorption (GO:0050892)2.41436062
192regulation of superoxide anion generation (GO:0032928)2.40248526
193cholesterol efflux (GO:0033344)2.40146291
194positive regulation of guanylate cyclase activity (GO:0031284)2.38007546

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.63409320
2* RXR_22158963_ChIP-Seq_LIVER_Mouse5.77314136
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.15411251
4PPARA_22158963_ChIP-Seq_LIVER_Mouse5.08019339
5LXR_22158963_ChIP-Seq_LIVER_Mouse4.57301750
6EGR1_23403033_ChIP-Seq_LIVER_Mouse3.35308746
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.12992934
8RARG_19884340_ChIP-ChIP_MEFs_Mouse2.66016135
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.64288844
10CLOCK_20551151_ChIP-Seq_293T_Human2.59601893
11TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.53432591
12ESR1_21235772_ChIP-Seq_MCF-7_Human2.51618238
13CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.47518031
14TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.16936005
15CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.16258042
16HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.16236050
17NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.12839953
18TRIM28_21343339_ChIP-Seq_HEK293_Human2.12838097
19* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.09955954
20NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.08673521
21ESR2_21235772_ChIP-Seq_MCF-7_Human2.03249780
22IRF8_22096565_ChIP-ChIP_GC-B_Human1.98831813
23BP1_19119308_ChIP-ChIP_Hs578T_Human1.95207363
24CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.91449527
25IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.76110175
26TP63_17297297_ChIP-ChIP_HaCaT_Human1.73877309
27* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.69697224
28* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.61487360
29STAT4_19710469_ChIP-ChIP_TH1__Mouse1.61044210
30KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.60183593
31KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.60183593
32KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.60183593
33IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.59124266
34SOX2_27498859_Chip-Seq_STOMACH_Mouse1.59065368
35TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.58158965
36* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.58121729
37CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.57408876
38CDX2_20551321_ChIP-Seq_CACO-2_Human1.54598115
39THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.50535559
40VDR_24763502_ChIP-Seq_THP-1_Human1.47255465
41POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.46983780
42LXR_22292898_ChIP-Seq_THP-1_Human1.46077782
43Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.43597831
44GATA4_25053715_ChIP-Seq_YYC3_Human1.43454160
45TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.41077214
46TCF3_18692474_ChIP-Seq_MEFs_Mouse1.40959789
47PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.39914271
48* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.39046842
49FOXA2_19822575_ChIP-Seq_HepG2_Human1.37389685
50ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.36987800
51GATA2_21666600_ChIP-Seq_HMVEC_Human1.33575680
52IRF8_27001747_Chip-Seq_BMDM_Mouse1.32512223
53SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.32094371
54OCT4_18692474_ChIP-Seq_MEFs_Mouse1.26027153
55FOXO3_23340844_ChIP-Seq_DLD1_Human1.25778293
56IRF8_21731497_ChIP-ChIP_J774_Mouse1.25249170
57CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.25188323
58* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.22969691
59SOX2_20726797_ChIP-Seq_SW620_Human1.22692419
60STAT1_20625510_ChIP-Seq_HELA_Human1.22098306
61HNF4A_19822575_ChIP-Seq_HepG2_Human1.19874227
62STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.18350869
63NANOG_18692474_ChIP-Seq_MEFs_Mouse1.18260690
64ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.17918521
65PPAR_26484153_Chip-Seq_NCI-H1993_Human1.17630262
66* RACK7_27058665_Chip-Seq_MCF-7_Human1.17460793
67SPI1_23127762_ChIP-Seq_K562_Human1.16982614
68TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.16174887
69SALL4_18804426_ChIP-ChIP_XEN_Mouse1.16144351
70* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15646484
71SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.13647681
72SOX2_18692474_ChIP-Seq_MEFs_Mouse1.12888546
73VDR_21846776_ChIP-Seq_THP-1_Human1.12430931
74MYB_21317192_ChIP-Seq_ERMYB_Mouse1.12283341
75CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.11310250
76KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.10812950
77PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08578835
78SA1_27219007_Chip-Seq_Bcells_Human1.07781468
79TBX20_22328084_ChIP-Seq_HEART_Mouse1.06746422
80TBX20_22080862_ChIP-Seq_HEART_Mouse1.06746422
81SRY_22984422_ChIP-ChIP_TESTIS_Rat1.06617058
82MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.06437893
83GATA1_22025678_ChIP-Seq_K562_Human1.06081967
84SPI1_23547873_ChIP-Seq_NB4_Human1.05952612
85NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.05049088
86NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.03642583
87STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.03361915
88* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.03117822
89BCL6_27268052_Chip-Seq_Bcells_Human1.02507795
90STAT3_1855785_ChIP-Seq_MESCs_Mouse1.02155374
91BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.01863073
92SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.01584281
93* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00639546
94NFIB_24661679_ChIP-Seq_LUNG_Mouse1.00341917
95NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.00098346
96SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.99673896
97GATA6_25053715_ChIP-Seq_YYC3_Human0.98515897
98GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.98364563
99FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.98325412
100CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97893554
101* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.97887272
102BCOR_27268052_Chip-Seq_Bcells_Human0.97486810
103GATA1_19941826_ChIP-Seq_K562_Human0.96750776
104IKZF1_21737484_ChIP-ChIP_HCT116_Human0.95813737
105ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.95585477
106GATA2_19941826_ChIP-Seq_K562_Human0.95178205
107LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.94185402
108P63_26484246_Chip-Seq_KERATINOCYTES_Human0.94050324
109ELK3_25401928_ChIP-Seq_HUVEC_Human0.93636178
110* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.91409364
111VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.91170916
112EGR1_19032775_ChIP-ChIP_M12_Human0.90447624
113SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.90196608
114ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.88769298
115ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.85659803
116KDM2B_26808549_Chip-Seq_SUP-B15_Human0.84258537
117TFEB_21752829_ChIP-Seq_HELA_Human0.83694926
118AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.83578047
119SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.83377228
120* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.82751500
121GATA1_19941827_ChIP-Seq_MEL_Mouse0.80722974
122SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.80267631
123* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.79666529
124VDR_24787735_ChIP-Seq_THP-1_Human0.79366605
125KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.78440060
126NRF2_20460467_ChIP-Seq_MEFs_Mouse0.76000496
127NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.76000496
128CJUN_26792858_Chip-Seq_BT549_Human0.74184214
129CDX2_19796622_ChIP-Seq_MESCs_Mouse0.73193732
130HIF1A_21447827_ChIP-Seq_MCF-7_Human0.72961890
131* MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.72649953
132RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.72216822
133FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.71602571
134PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.71328168
135* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.71111054
136PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.70769906
137E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.70222403
138SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.69613572
139BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.69222498
140TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.68752401
141SCL_19346495_ChIP-Seq_HPC-7_Human0.67578329
142LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.66967048
143* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.65401641
144RAD21_21589869_ChIP-Seq_MESCs_Mouse0.64933373
145* ATF3_27146783_Chip-Seq_COLON_Human0.64692073
146FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.64331592

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis6.98934487
2MP0002139_abnormal_hepatobiliary_system5.42562317
3MP0003303_peritoneal_inflammation4.10486205
4MP0005332_abnormal_amino_acid3.61463851
5MP0004019_abnormal_vitamin_homeostasis3.56193072
6MP0005365_abnormal_bile_salt3.48850313
7MP0008875_abnormal_xenobiotic_pharmacok3.42226162
8MP0005085_abnormal_gallbladder_physiolo3.36430794
9MP0004043_abnormal_pH_regulation3.19841626
10MP0002138_abnormal_hepatobiliary_system3.16616879
11MP0003195_calcinosis2.93918084
12MP0009643_abnormal_urine_homeostasis2.89544370
13MP0003252_abnormal_bile_duct2.84244491
14MP0005058_abnormal_lysosome_morphology2.81094164
15MP0002148_abnormal_hypersensitivity_rea2.52702316
16MP0003191_abnormal_cellular_cholesterol2.42028748
17MP0003806_abnormal_nucleotide_metabolis2.34727316
18MP0009840_abnormal_foam_cell2.20603478
19MP0009785_altered_susceptibility_to2.19483790
20MP0001756_abnormal_urination2.12637642
21MP0001765_abnormal_ion_homeostasis2.11848029
22MP0010155_abnormal_intestine_physiology2.03186904
23MP0010329_abnormal_lipoprotein_level2.03156366
24MP0005636_abnormal_mineral_homeostasis2.01677761
25MP0002136_abnormal_kidney_physiology1.98807530
26MP0004510_myositis1.96130566
27MP0001666_abnormal_nutrient_absorption1.86719191
28MP0003300_gastrointestinal_ulcer1.83788749
29MP0001835_abnormal_antigen_presentation1.83654951
30MP0005025_abnormal_response_to1.80158958
31MP0003724_increased_susceptibility_to1.78555032
32MP0001958_emphysema1.78118337
33MP0001790_abnormal_immune_system1.74518178
34MP0005387_immune_system_phenotype1.74518178
35MP0003186_abnormal_redox_activity1.65359436
36MP0005319_abnormal_enzyme/_coenzyme1.63985581
37MP0005584_abnormal_enzyme/coenzyme_acti1.56372090
38MP0005671_abnormal_response_to1.51673610
39MP0010368_abnormal_lymphatic_system1.51607537
40MP0003329_amyloid_beta_deposits1.50993813
41MP0001853_heart_inflammation1.50836661
42MP0002118_abnormal_lipid_homeostasis1.48213500
43MP0005000_abnormal_immune_tolerance1.42951265
44MP0005670_abnormal_white_adipose1.42767881
45MP0000609_abnormal_liver_physiology1.41841768
46MP0003878_abnormal_ear_physiology1.40256969
47MP0005377_hearing/vestibular/ear_phenot1.40256969
48MP0005257_abnormal_intraocular_pressure1.39132956
49MP0005083_abnormal_biliary_tract1.37372472
50MP0002452_abnormal_antigen_presenting1.36632839
51MP0003705_abnormal_hypodermis_morpholog1.35704094
52MP0003448_altered_tumor_morphology1.31070686
53MP0008260_abnormal_autophagy1.23554229
54MP0003172_abnormal_lysosome_physiology1.18697094
55MP0002723_abnormal_immune_serum1.18617577
56MP0001764_abnormal_homeostasis1.18008292
57MP0006054_spinal_hemorrhage1.14914790
58MP0000490_abnormal_crypts_of1.13494663
59MP0009764_decreased_sensitivity_to1.12463178
60MP0005084_abnormal_gallbladder_morpholo1.11626448
61MP0001849_ear_inflammation1.09275150
62MP0000685_abnormal_immune_system1.09040561
63MP0005451_abnormal_body_composition1.08746167
64MP0003453_abnormal_keratinocyte_physiol1.08192639
65MP0005310_abnormal_salivary_gland1.07861108
66MP0005167_abnormal_blood-brain_barrier1.07076524
67MP0008469_abnormal_protein_level1.04585742
68MP0000538_abnormal_urinary_bladder1.02561564
69MP0000858_altered_metastatic_potential1.01768381
70MP0003879_abnormal_hair_cell1.00539595
71MP0004947_skin_inflammation0.99146141
72MP0002928_abnormal_bile_duct0.98574172
73MP0001800_abnormal_humoral_immune0.98533784
74MP0004272_abnormal_basement_membrane0.98427968
75MP0002168_other_aberrant_phenotype0.97538606
76MP0001879_abnormal_lymphatic_vessel0.97526617
77MP0004264_abnormal_extraembryonic_tissu0.95531134
78MP0003436_decreased_susceptibility_to0.95372955
79MP0005666_abnormal_adipose_tissue0.95340277
80MP0001819_abnormal_immune_cell0.95037955
81MP0000230_abnormal_systemic_arterial0.94859514
82MP0008438_abnormal_cutaneous_collagen0.94817289
83MP0000598_abnormal_liver_morphology0.93738966
84MP0003075_altered_response_to0.93524523
85MP0002135_abnormal_kidney_morphology0.93152306
86MP0002420_abnormal_adaptive_immunity0.92074527
87MP0004858_abnormal_nervous_system0.88564024
88MP0009642_abnormal_blood_homeostasis0.88510529
89MP0008961_abnormal_basal_metabolism0.86670874
90MP0009278_abnormal_bone_marrow0.83832153
91MP0000920_abnormal_myelination0.83772456
92MP0005595_abnormal_vascular_smooth0.82841535
93MP0010234_abnormal_vibrissa_follicle0.82003061
94MP0003638_abnormal_response/metabolism_0.80851182
95MP0000604_amyloidosis0.78599697
96MP0003011_delayed_dark_adaptation0.77984213
97MP0001533_abnormal_skeleton_physiology0.77977448
98MP0002405_respiratory_system_inflammati0.77369629
99MP0005381_digestive/alimentary_phenotyp0.76684975
100MP0005165_increased_susceptibility_to0.75185763
101MP0000343_altered_response_to0.74949552
102MP0003828_pulmonary_edema0.74239821
103MP0006036_abnormal_mitochondrial_physio0.74124205
104MP0005164_abnormal_response_to0.74005301
105MP0003566_abnormal_cell_adhesion0.73828266
106MP0002876_abnormal_thyroid_physiology0.73542471
107MP0005408_hypopigmentation0.72752828
108MP0002896_abnormal_bone_mineralization0.72745130
109MP0001845_abnormal_inflammatory_respons0.72070120
110MP0005535_abnormal_body_temperature0.71940332
111MP0005390_skeleton_phenotype0.71853612
112MP0005220_abnormal_exocrine_pancreas0.71834023
113MP0002090_abnormal_vision0.71442115
114MP0003690_abnormal_glial_cell0.70049425
115MP0009379_abnormal_foot_pigmentation0.70022160
116MP0002254_reproductive_system_inflammat0.68457856
117MP0009333_abnormal_splenocyte_physiolog0.68141430
118MP0009763_increased_sensitivity_to0.67977415
119MP0005464_abnormal_platelet_physiology0.66237687
120MP0006082_CNS_inflammation0.66118740
121MP0002419_abnormal_innate_immunity0.65829374
122MP0001501_abnormal_sleep_pattern0.64465908
123MP0000465_gastrointestinal_hemorrhage0.64307176
124MP0001542_abnormal_bone_strength0.63597271
125MP0010386_abnormal_urinary_bladder0.62640809
126MP0002998_abnormal_bone_remodeling0.62604392
127MP0004782_abnormal_surfactant_physiolog0.62100957
128MP0004147_increased_porphyrin_level0.61420578
129MP0000249_abnormal_blood_vessel0.59977988
130MP0002796_impaired_skin_barrier0.59053073
131MP0002971_abnormal_brown_adipose0.58385147
132MP0002295_abnormal_pulmonary_circulatio0.58243128
133MP0003183_abnormal_peptide_metabolism0.57559677
134MP0002078_abnormal_glucose_homeostasis0.57408249
135MP0005166_decreased_susceptibility_to0.56967202
136MP0001661_extended_life_span0.56843394
137MP0008004_abnormal_stomach_pH0.54707990
138MP0002089_abnormal_postnatal_growth/wei0.54004941
139MP0005376_homeostasis/metabolism_phenot0.53854483
140MP0004130_abnormal_muscle_cell0.53667908
141MP0003795_abnormal_bone_structure0.52549788
142MP0005375_adipose_tissue_phenotype0.52424324
143MP0005395_other_phenotype0.51415595
144MP0000371_diluted_coat_color0.49559618
145MP0001663_abnormal_digestive_system0.46891082
146MP0004885_abnormal_endolymph0.46849033

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of liposaccharide metabolism (HP:0010968)7.27436101
2Abnormality of glycosphingolipid metabolism (HP:0004343)7.27436101
3Abnormality of glycolipid metabolism (HP:0010969)7.27436101
4Gout (HP:0001997)5.36988422
5Hypokalemic alkalosis (HP:0001949)5.05902968
6Increased cerebral lipofuscin (HP:0011813)5.04411042
7Increased circulating renin level (HP:0000848)4.96996196
8Hyperactive renin-angiotensin system (HP:0000841)4.85232068
9Abnormality of glutamine family amino acid metabolism (HP:0010902)4.78596742
10Metabolic alkalosis (HP:0200114)4.74048777
11Hyperglycinuria (HP:0003108)4.63767509
12Loss of speech (HP:0002371)4.47697294
13Abnormality of chloride homeostasis (HP:0011422)4.34119619
14Polyuria (HP:0000103)4.32723128
15Abnormal urine output (HP:0012590)4.26662272
16Hypomagnesemia (HP:0002917)4.26128754
17Disinhibition (HP:0000734)4.25268282
18Proximal tubulopathy (HP:0000114)4.22527993
19Abnormality of purine metabolism (HP:0004352)4.17302230
20Abnormality of renal excretion (HP:0011036)4.16135711
21Abnormality of macrophages (HP:0004311)4.15499192
22Increased neuronal autofluorescent lipopigment (HP:0002074)3.95992547
23Abnormality of serine family amino acid metabolism (HP:0010894)3.89744051
24Abnormality of glycine metabolism (HP:0010895)3.89744051
25Hyperuricemia (HP:0002149)3.87760786
26Increased purine levels (HP:0004368)3.87760786
27Generalized aminoaciduria (HP:0002909)3.85406893
28Nuclear cataract (HP:0100018)3.85373678
29Vacuolated lymphocytes (HP:0001922)3.77262373
30Alkalosis (HP:0001948)3.75874934
31Mutism (HP:0002300)3.73476372
32Abnormality of magnesium homeostasis (HP:0004921)3.70953364
33Abnormality of aromatic amino acid family metabolism (HP:0004338)3.69807679
34Ketoacidosis (HP:0001993)3.69343579
35Ketosis (HP:0001946)3.64213316
36Systemic lupus erythematosus (HP:0002725)3.42299055
37Polydipsia (HP:0001959)3.38262419
38Abnormal drinking behavior (HP:0030082)3.38262419
39Abnormality of nucleobase metabolism (HP:0010932)3.36839639
40Renal salt wasting (HP:0000127)3.35505052
41Abnormality of fatty-acid metabolism (HP:0004359)3.33735991
42Tetany (HP:0001281)3.33692134
43Neurofibrillary tangles (HP:0002185)3.30327343
44Xanthomatosis (HP:0000991)3.28947520
45Abnormality of renin-angiotensin system (HP:0000847)3.28941645
46Hyperammonemia (HP:0001987)3.22902783
47Abnormality of proline metabolism (HP:0010907)3.22329946
48Hydroxyprolinuria (HP:0003080)3.22329946
49Hyperaldosteronism (HP:0000859)3.14504468
50Eczematoid dermatitis (HP:0000976)3.11207066
51Vascular calcification (HP:0004934)3.04137540
52Abnormality of urine glucose concentration (HP:0011016)3.02635073
53Glycosuria (HP:0003076)3.02635073
54Abnormality of aspartate family amino acid metabolism (HP:0010899)3.02565880
55Hyperglycinemia (HP:0002154)2.97026321
56Abnormality of monocarboxylic acid metabolism (HP:0010996)2.96320044
57Deep venous thrombosis (HP:0002625)2.95787242
58Intrahepatic cholestasis (HP:0001406)2.91986718
59Renal tubular acidosis (HP:0001947)2.88652907
60Abnormality of the vasculature of the conjunctiva (HP:0008054)2.88400727
61Amyloidosis (HP:0011034)2.84726288
62Hematochezia (HP:0002573)2.84472025
63Dysostosis multiplex (HP:0000943)2.82841183
64Autoimmune thrombocytopenia (HP:0001973)2.81000151
65Progressive neurologic deterioration (HP:0002344)2.79962197
66Abnormality of sulfur amino acid metabolism (HP:0004339)2.78501389
67Cardiovascular calcification (HP:0011915)2.77915522
68Urinary glycosaminoglycan excretion (HP:0003541)2.73508801
69Mucopolysacchariduria (HP:0008155)2.73508801
70Delayed CNS myelination (HP:0002188)2.72829340
71Complement deficiency (HP:0004431)2.66843934
72Hypoglycemic coma (HP:0001325)2.64978789
73Apathy (HP:0000741)2.62954179
74Recurrent bacterial skin infections (HP:0005406)2.62864131
75Recurrent abscess formation (HP:0002722)2.59575548
76Diminished motivation (HP:0000745)2.56453089
77Hypercalciuria (HP:0002150)2.55387013
78Nephrolithiasis (HP:0000787)2.54937410
79Agnosia (HP:0010524)2.54038962
80Malnutrition (HP:0004395)2.53464465
81Myocardial infarction (HP:0001658)2.52837622
82Abnormality of mucopolysaccharide metabolism (HP:0011020)2.51359259
83Abnormality of polysaccharide metabolism (HP:0011012)2.51359259
84Abnormality of glycosaminoglycan metabolism (HP:0004371)2.51359259
85Hypokalemia (HP:0002900)2.51133066
86Prolonged neonatal jaundice (HP:0006579)2.47831194
87Peripheral demyelination (HP:0011096)2.44933394
88Recurrent gram-negative bacterial infections (HP:0005420)2.42793190
89Hepatosplenomegaly (HP:0001433)2.42616017
90Orchitis (HP:0100796)2.40414779
91Metabolic acidosis (HP:0001942)2.40209591
92Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.40007506
93Abnormal enzyme/coenzyme activity (HP:0012379)2.36799557
94Hyperphosphaturia (HP:0003109)2.36198151
95Hypophosphatemia (HP:0002148)2.35615711
96Dementia (HP:0000726)2.35021294
97Glomerulonephritis (HP:0000099)2.34534621
98Axonal loss (HP:0003447)2.32673288
99Purpura (HP:0000979)2.27253537
100Rickets (HP:0002748)2.26209961
101Joint hemorrhage (HP:0005261)2.25712059
102Abnormal urine phosphate concentration (HP:0012599)2.25266670
103Abnormality of alkaline phosphatase activity (HP:0004379)2.25251812
104Polyphagia (HP:0002591)2.23123525
105Neuronal loss in central nervous system (HP:0002529)2.22584243
106* Dicarboxylic aciduria (HP:0003215)2.20263785
107* Abnormality of dicarboxylic acid metabolism (HP:0010995)2.20263785
108Conjunctival telangiectasia (HP:0000524)2.18322861
109Petechiae (HP:0000967)2.15982539
110Retinal atrophy (HP:0001105)2.13499645
111* Vomiting (HP:0002013)2.12211203
112Abnormality of potassium homeostasis (HP:0011042)2.08788265
113Mediastinal lymphadenopathy (HP:0100721)2.08732708
114Metaphyseal irregularity (HP:0003025)2.08295766
115Myositis (HP:0100614)2.07786288
116Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.07073962
117Inappropriate behavior (HP:0000719)2.06847374
118Abnormality of the nasal mucosa (HP:0000433)2.06283828
119Lymphangioma (HP:0100764)2.06263176
120Abnormality of complement system (HP:0005339)2.05998292
121Nephrocalcinosis (HP:0000121)2.05977379
122Cerebral inclusion bodies (HP:0100314)2.05756129
123Premature loss of primary teeth (HP:0006323)2.04204981
124Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.04063929
125Abnormality of the vitamin B12 metabolism (HP:0004341)2.03223804
126Late onset (HP:0003584)2.03135930
127Enlarged kidneys (HP:0000105)2.02903466
128Nausea (HP:0002018)2.02224389
129Elevated alkaline phosphatase (HP:0003155)2.01143642
130Metaphyseal cupping (HP:0003021)2.00529721
131Hepatocellular carcinoma (HP:0001402)1.99181036
132Sensorimotor neuropathy (HP:0007141)1.99130308
133Chondrocalcinosis (HP:0000934)1.98594970
134Optic neuritis (HP:0100653)1.98060948
135Retrobulbar optic neuritis (HP:0100654)1.98060948
136Upper motor neuron abnormality (HP:0002127)1.96695429
137Increased CSF protein (HP:0002922)1.96087948
138Tetraparesis (HP:0002273)1.95851692
139Abnormal tarsal ossification (HP:0008369)1.94581178
140Bone pain (HP:0002653)1.94163628
141Widely patent fontanelles and sutures (HP:0004492)1.93591633
142Pathologic fracture (HP:0002756)1.93499265
143Fat malabsorption (HP:0002630)1.93232722
144Gingivitis (HP:0000230)1.92488888
145Chronic diarrhea (HP:0002028)1.92318852
146Nephritis (HP:0000123)1.92026481
147Dehydration (HP:0001944)1.91293126
148Esophageal varix (HP:0002040)1.91277232
149Abnormality of vitamin B metabolism (HP:0004340)1.91250227
150Steatorrhea (HP:0002570)1.90472710
151Facial shape deformation (HP:0011334)1.89650758
152Potter facies (HP:0002009)1.89650758
153Increased IgM level (HP:0003496)1.87707623
154* Lethargy (HP:0001254)1.87373791
155Hyperlipoproteinemia (HP:0010980)1.86986018
156Delayed epiphyseal ossification (HP:0002663)1.86005561
157Cardiomegaly (HP:0001640)1.81461536
158Vertebral compression fractures (HP:0002953)1.80589699
159Increased serum ferritin (HP:0003281)1.79693918
160Asymmetric septal hypertrophy (HP:0001670)1.79623986
161Mucosal telangiectasiae (HP:0100579)1.79549712
162Confusion (HP:0001289)1.78061929
163Spontaneous hematomas (HP:0007420)1.76116528
164Subcapsular cataract (HP:0000523)1.76062246
165Zonular cataract (HP:0010920)1.75924902
166Abnormality of vitamin metabolism (HP:0100508)1.75213812
167Abnormality of the periventricular white matter (HP:0002518)1.73527253
168Personality changes (HP:0000751)1.73492719
169Wide cranial sutures (HP:0010537)1.71687787
170Bone cyst (HP:0012062)1.69518846
171Interstitial pulmonary disease (HP:0006530)1.69098461
172Polygenic inheritance (HP:0010982)1.68723075
173Posterior subcapsular cataract (HP:0007787)1.67412890

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK45.74228998
2WNK34.62613183
3ACVR1B4.60585870
4OXSR14.14215542
5BCKDK4.11047753
6ERN13.55143842
7NME23.16645974
8KDR3.01324406
9TGFBR22.86862916
10STK162.83225780
11TIE12.74586436
12DDR22.68386296
13STK392.39365352
14MST1R2.35646842
15GRK72.23327815
16TRIB32.20856352
17EPHB12.14883801
18FGFR42.06920115
19TESK22.04082174
20FGR1.97809550
21TNIK1.87747895
22TAOK21.77074014
23TESK11.75672599
24SIK11.67983142
25PIM21.57316031
26PTK61.56702020
27STK38L1.52860233
28RIPK11.50298652
29PKN21.46873304
30LRRK21.32828974
31PDK21.28537274
32CDC42BPA1.26534495
33ADRBK21.26071427
34MOS1.24610246
35MET1.20301497
36MAP3K31.19277590
37PRPF4B1.17552590
38INSRR1.17205236
39TYK21.16867511
40MAP2K31.14270607
41PDK31.13241696
42PDK41.13241696
43IRAK31.11340502
44IKBKE1.09485427
45PAK41.05874224
46TAOK11.05484752
47MAPK151.05484258
48CAMK1D1.01141893
49BLK1.00404036
50TBK10.98411476
51MYLK0.95891059
52RIPK40.94336956
53TAOK30.93712332
54PTK20.93461344
55MAP3K10.93236825
56GRK60.92089913
57IKBKB0.90415671
58SGK4940.89426640
59SGK2230.89426640
60MAP3K140.89332387
61FLT30.86707133
62GSK3A0.86139259
63WNK10.84882714
64JAK10.82924660
65CSK0.81420837
66DMPK0.80841040
67STK100.80486799
68FRK0.78013715
69MAP4K10.77645279
70JAK20.76892286
71SGK30.74099583
72ZAP700.72944064
73MAP3K120.72718664
74LYN0.71942700
75NEK90.69930032
76TGFBR10.68937041
77FES0.67185481
78MST40.66428331
79DYRK1B0.66409871
80MAP2K20.65965641
81CAMK1G0.65950401
82PRKAA20.65256852
83MAPK110.64734896
84NEK10.64313498
85ARAF0.63655598
86BTK0.63510059
87MAP3K110.63436428
88PIK3CG0.62976226
89DAPK30.60843121
90EPHA30.60470907
91STK380.60178884
92FER0.60050273
93ABL20.59280310
94MAP3K70.58692548
95LIMK10.57336164
96BMX0.57152843
97KIT0.55832872
98STK240.55330948
99NLK0.55187281
100LATS10.53323324
101PDPK10.52751519
102MAP3K50.52615815
103CSF1R0.49870639
104PIM10.49243897
105MAPK70.49169192
106SIK30.49029191
107EPHB20.46807407
108MAP2K60.45608083
109IRAK20.45576649
110LMTK20.44293322
111MAPK120.43246489
112EPHA20.42968320
113ITK0.42375680
114TTN0.41317078
115JAK30.41279328
116MATK0.41163456
117PTK2B0.40663470
118IGF1R0.40538352
119MAP3K80.38549355
120PRKAA10.38511787
121PINK10.38304821
122CHUK0.38240188
123SGK20.36398322
124CDK190.36285791
125MAPKAPK30.35959942
126PDGFRA0.35754663
127TEC0.35093949
128PRKCD0.34183952
129GRK10.34110647
130PRKG20.33906313
131IRAK40.33238172
132SRC0.31424856
133CDK60.31081213
134DAPK20.31015023
135IRAK10.30858383
136INSR0.29769920
137PDK10.28110573
138EGFR0.27697986
139PBK0.26730577
140LCK0.26566871
141MAPK40.26484745
142MAP3K100.25962621
143MAP3K20.25683513
144ERBB40.24917678
145PRKACG0.24395295
146FGFR30.24149198

Predicted pathways (KEGG)

RankGene SetZ-score
1Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.42663899
2Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.89335926
3Pentose and glucuronate interconversions_Homo sapiens_hsa000402.87006496
4Asthma_Homo sapiens_hsa053102.73401088
5Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.72110764
6Butanoate metabolism_Homo sapiens_hsa006502.62767816
7Fatty acid degradation_Homo sapiens_hsa000712.59595835
8Propanoate metabolism_Homo sapiens_hsa006402.57277665
9Tryptophan metabolism_Homo sapiens_hsa003802.43055272
10Primary bile acid biosynthesis_Homo sapiens_hsa001202.34984172
11Peroxisome_Homo sapiens_hsa041462.31154195
12Allograft rejection_Homo sapiens_hsa053302.29554084
13Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.24734273
14Cyanoamino acid metabolism_Homo sapiens_hsa004602.24698546
152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.19500327
16Nitrogen metabolism_Homo sapiens_hsa009102.18836406
17Rheumatoid arthritis_Homo sapiens_hsa053232.16646566
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.11446045
19Intestinal immune network for IgA production_Homo sapiens_hsa046722.07629561
20Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.07157800
21Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.02795161
22Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.98206645
23Arginine biosynthesis_Homo sapiens_hsa002201.94607682
24Autoimmune thyroid disease_Homo sapiens_hsa053201.94126362
25Fatty acid metabolism_Homo sapiens_hsa012121.92612052
26Pyruvate metabolism_Homo sapiens_hsa006201.82399003
27Sulfur metabolism_Homo sapiens_hsa009201.81214638
28Graft-versus-host disease_Homo sapiens_hsa053321.81151732
29beta-Alanine metabolism_Homo sapiens_hsa004101.79967942
30PPAR signaling pathway_Homo sapiens_hsa033201.76125953
31Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.72254933
32Other glycan degradation_Homo sapiens_hsa005111.68968326
33Complement and coagulation cascades_Homo sapiens_hsa046101.66903370
34Staphylococcus aureus infection_Homo sapiens_hsa051501.64955552
35Bile secretion_Homo sapiens_hsa049761.63518135
36Histidine metabolism_Homo sapiens_hsa003401.59398596
37Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.57945024
38Starch and sucrose metabolism_Homo sapiens_hsa005001.53615569
39Type I diabetes mellitus_Homo sapiens_hsa049401.44395130
40Antigen processing and presentation_Homo sapiens_hsa046121.42682427
41Carbon metabolism_Homo sapiens_hsa012001.41324517
42Glycosaminoglycan degradation_Homo sapiens_hsa005311.36180136
43* Vitamin digestion and absorption_Homo sapiens_hsa049771.34950377
44Selenocompound metabolism_Homo sapiens_hsa004501.34153806
45Caffeine metabolism_Homo sapiens_hsa002321.32669860
46Glutathione metabolism_Homo sapiens_hsa004801.31779086
47Chemical carcinogenesis_Homo sapiens_hsa052041.28283856
48Osteoclast differentiation_Homo sapiens_hsa043801.27902896
49Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.25346079
50Tuberculosis_Homo sapiens_hsa051521.24474010
51Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.23571652
52Arginine and proline metabolism_Homo sapiens_hsa003301.23565730
53Toll-like receptor signaling pathway_Homo sapiens_hsa046201.21340811
54Drug metabolism - other enzymes_Homo sapiens_hsa009831.20830363
55Folate biosynthesis_Homo sapiens_hsa007901.19255073
56Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.15195163
57Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.12983870
58Steroid hormone biosynthesis_Homo sapiens_hsa001401.12613981
59Lysosome_Homo sapiens_hsa041421.12319635
60Phenylalanine metabolism_Homo sapiens_hsa003601.07344916
61Lysine degradation_Homo sapiens_hsa003101.05550512
62Maturity onset diabetes of the young_Homo sapiens_hsa049501.02975671
63Viral myocarditis_Homo sapiens_hsa054161.00393228
64Salmonella infection_Homo sapiens_hsa051320.98780266
65Retinol metabolism_Homo sapiens_hsa008300.97946569
66Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.97334227
67Biosynthesis of amino acids_Homo sapiens_hsa012300.95973964
68Fatty acid elongation_Homo sapiens_hsa000620.94438396
69NF-kappa B signaling pathway_Homo sapiens_hsa040640.94261097
70Glycerolipid metabolism_Homo sapiens_hsa005610.91565507
71Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.90364561
72ABC transporters_Homo sapiens_hsa020100.89697556
73Prion diseases_Homo sapiens_hsa050200.88812291
74Toxoplasmosis_Homo sapiens_hsa051450.87800335
75African trypanosomiasis_Homo sapiens_hsa051430.84899071
76Fat digestion and absorption_Homo sapiens_hsa049750.84748347
77Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.83758294
78Pentose phosphate pathway_Homo sapiens_hsa000300.83248362
79Protein digestion and absorption_Homo sapiens_hsa049740.82861355
80Mineral absorption_Homo sapiens_hsa049780.81023573
81TNF signaling pathway_Homo sapiens_hsa046680.78084418
82Renin-angiotensin system_Homo sapiens_hsa046140.76424714
83Tyrosine metabolism_Homo sapiens_hsa003500.74657677
84Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.72342401
85Fructose and mannose metabolism_Homo sapiens_hsa000510.71985524
86Influenza A_Homo sapiens_hsa051640.70126048
87Vibrio cholerae infection_Homo sapiens_hsa051100.68956831
88Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.66583764
89Collecting duct acid secretion_Homo sapiens_hsa049660.64907495
90Galactose metabolism_Homo sapiens_hsa000520.64891186
91Cysteine and methionine metabolism_Homo sapiens_hsa002700.62749268
92Ether lipid metabolism_Homo sapiens_hsa005650.62604536
93Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.62351019
94Hematopoietic cell lineage_Homo sapiens_hsa046400.61132553
95Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.60997655
96Steroid biosynthesis_Homo sapiens_hsa001000.60657860
97Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.58352038
98Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.56078468
99Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.55466045
100NOD-like receptor signaling pathway_Homo sapiens_hsa046210.54249790
101RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.54188332
102Sulfur relay system_Homo sapiens_hsa041220.50799225
103Carbohydrate digestion and absorption_Homo sapiens_hsa049730.49700977
104Arachidonic acid metabolism_Homo sapiens_hsa005900.47960418
105Oxidative phosphorylation_Homo sapiens_hsa001900.45323689
106Metabolic pathways_Homo sapiens_hsa011000.44879355
107Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.43016982
108Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.42921671
109Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.38277124
110Herpes simplex infection_Homo sapiens_hsa051680.38248485
111Proteasome_Homo sapiens_hsa030500.37256209
112Thyroid hormone synthesis_Homo sapiens_hsa049180.36615660
113Insulin resistance_Homo sapiens_hsa049310.36536977
114Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.36271861
115Linoleic acid metabolism_Homo sapiens_hsa005910.32142478
116Chemokine signaling pathway_Homo sapiens_hsa040620.32047473
117Adipocytokine signaling pathway_Homo sapiens_hsa049200.31448922
118Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.27515614
119Fatty acid biosynthesis_Homo sapiens_hsa000610.25099796
120Leukocyte transendothelial migration_Homo sapiens_hsa046700.21861836
121Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.21078039
122Malaria_Homo sapiens_hsa051440.15011069
123alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.14449082
124Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.12707788
125Pertussis_Homo sapiens_hsa051330.12707162
126Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.09733365
127Phagosome_Homo sapiens_hsa041450.09280821
128Sphingolipid metabolism_Homo sapiens_hsa006000.07883464
129Amoebiasis_Homo sapiens_hsa051460.06369296
130Hepatitis C_Homo sapiens_hsa051600.05821906
131ECM-receptor interaction_Homo sapiens_hsa045120.05190372
132Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.04590134
133Leishmaniasis_Homo sapiens_hsa051400.03687297
134Legionellosis_Homo sapiens_hsa051340.03687136
135AMPK signaling pathway_Homo sapiens_hsa041520.02767303
136Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.02466678

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