TCP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized. In addition, three pseudogenes that appear to be derived from this gene have been found. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)5.95903188
2piRNA metabolic process (GO:0034587)5.31033375
3nuclear pore complex assembly (GO:0051292)5.03657510
4nuclear pore organization (GO:0006999)4.99734765
5* binding of sperm to zona pellucida (GO:0007339)4.96900049
6fusion of sperm to egg plasma membrane (GO:0007342)4.96451860
7* sperm-egg recognition (GO:0035036)4.95410098
8establishment of integrated proviral latency (GO:0075713)4.93283552
9male meiosis (GO:0007140)4.54745601
10acrosome assembly (GO:0001675)4.51967033
11synaptonemal complex assembly (GO:0007130)4.50268186
12DNA replication-dependent nucleosome organization (GO:0034723)4.41877398
13DNA replication-dependent nucleosome assembly (GO:0006335)4.41877398
14synaptonemal complex organization (GO:0070193)4.38186268
15* cell-cell recognition (GO:0009988)4.36648985
16DNA unwinding involved in DNA replication (GO:0006268)4.32295883
17protein localization to kinetochore (GO:0034501)4.19735274
18protein localization to chromosome, centromeric region (GO:0071459)4.09299577
19sperm motility (GO:0030317)4.07320163
20mitotic nuclear envelope disassembly (GO:0007077)4.06310023
21DNA strand elongation involved in DNA replication (GO:0006271)4.03369927
22regulation of centriole replication (GO:0046599)4.02755731
23pore complex assembly (GO:0046931)3.92455584
24proteasome assembly (GO:0043248)3.92066626
25mitotic metaphase plate congression (GO:0007080)3.90553628
26DNA replication initiation (GO:0006270)3.90149718
27chaperone-mediated protein complex assembly (GO:0051131)3.86546226
28axonemal dynein complex assembly (GO:0070286)3.84692268
29mitotic sister chromatid cohesion (GO:0007064)3.84553236
30multicellular organism reproduction (GO:0032504)3.82707067
31nuclear envelope disassembly (GO:0051081)3.81882791
32membrane disassembly (GO:0030397)3.81882791
33DNA strand elongation (GO:0022616)3.81096545
34histone exchange (GO:0043486)3.77628473
35establishment of viral latency (GO:0019043)3.75939852
36chromosome organization involved in meiosis (GO:0070192)3.75007184
37formation of translation preinitiation complex (GO:0001731)3.73321243
38mitotic chromosome condensation (GO:0007076)3.69239854
39mitotic sister chromatid segregation (GO:0000070)3.68806802
40DNA methylation involved in gamete generation (GO:0043046)3.68109249
41synapsis (GO:0007129)3.67313668
42spermatid development (GO:0007286)3.65449288
43nucleobase biosynthetic process (GO:0046112)3.64073800
44meiotic nuclear division (GO:0007126)3.59117821
45chromatin remodeling at centromere (GO:0031055)3.58344527
46ribosomal large subunit biogenesis (GO:0042273)3.58198541
47plasma membrane fusion (GO:0045026)3.57785149
48cell wall macromolecule metabolic process (GO:0044036)3.57198264
49cell wall macromolecule catabolic process (GO:0016998)3.57198264
50sister chromatid segregation (GO:0000819)3.56201599
51microtubule depolymerization (GO:0007019)3.55330870
52regulation of mitotic spindle organization (GO:0060236)3.55106003
53regulation of centrosome cycle (GO:0046605)3.54740031
54metaphase plate congression (GO:0051310)3.52906567
55regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.50110475
56telomere maintenance via semi-conservative replication (GO:0032201)3.49978561
57monoubiquitinated protein deubiquitination (GO:0035520)3.49404797
58translesion synthesis (GO:0019985)3.48657991
59double-strand break repair via nonhomologous end joining (GO:0006303)3.47789923
60non-recombinational repair (GO:0000726)3.47789923
61purine nucleobase biosynthetic process (GO:0009113)3.46988466
62motile cilium assembly (GO:0044458)3.46072980
63spindle checkpoint (GO:0031577)3.42803084
64gene silencing by RNA (GO:0031047)3.41828269
65CENP-A containing nucleosome assembly (GO:0034080)3.41692849
66chromosome condensation (GO:0030261)3.38903112
67mitotic spindle checkpoint (GO:0071174)3.37854078
68attachment of spindle microtubules to kinetochore (GO:0008608)3.37749797
69anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.35698805
70tRNA aminoacylation for protein translation (GO:0006418)3.35539028
71regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.34490334
72epithelial cilium movement (GO:0003351)3.34343257
73IMP biosynthetic process (GO:0006188)3.34286693
74tRNA aminoacylation (GO:0043039)3.34018824
75amino acid activation (GO:0043038)3.34018824
76kinetochore organization (GO:0051383)3.33939043
77regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.33646429
78mitotic recombination (GO:0006312)3.33603279
79DNA replication-independent nucleosome assembly (GO:0006336)3.33568246
80DNA replication-independent nucleosome organization (GO:0034724)3.33568246
81regulation of chromosome segregation (GO:0051983)3.33189013
82telomere maintenance via recombination (GO:0000722)3.32656564
83negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.32296239
84DNA replication checkpoint (GO:0000076)3.31536037
85regulation of histone H3-K9 methylation (GO:0051570)3.30831049
86negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.30280077
87regulation of spindle organization (GO:0090224)3.30277776
88DNA double-strand break processing (GO:0000729)3.26664440
89regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.25412509
90DNA ligation (GO:0006266)3.22591268
91mitotic spindle assembly checkpoint (GO:0007094)3.21916376
92postreplication repair (GO:0006301)3.21911811
93regulation of translational fidelity (GO:0006450)3.21247535
94DNA packaging (GO:0006323)3.20549414
95spindle assembly checkpoint (GO:0071173)3.20312677
96DNA geometric change (GO:0032392)3.19840379
97DNA duplex unwinding (GO:0032508)3.19727695
98establishment of chromosome localization (GO:0051303)3.19120279
99regulation of sister chromatid segregation (GO:0033045)3.18038548
100regulation of mitotic sister chromatid separation (GO:0010965)3.18038548
101regulation of mitotic sister chromatid segregation (GO:0033047)3.18038548
102ribosome biogenesis (GO:0042254)3.17803276
103folic acid-containing compound biosynthetic process (GO:0009396)3.17781143
104maturation of 5.8S rRNA (GO:0000460)3.16586044
105establishment of protein localization to mitochondrial membrane (GO:0090151)3.14976718
106positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.14218432
107heterochromatin organization (GO:0070828)3.14217069
108positive regulation of chromosome segregation (GO:0051984)3.13725931
109spliceosomal snRNP assembly (GO:0000387)3.13716613
110epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.13253586
111negative regulation of DNA repair (GO:0045738)3.13032582
112ribosome assembly (GO:0042255)3.12482262
113DNA topological change (GO:0006265)3.12407632
114meiotic chromosome segregation (GO:0045132)3.11718695
115negative regulation of chromosome segregation (GO:0051985)3.09749026
116reproduction (GO:0000003)3.09700913
117negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.09568975
118negative regulation of ligase activity (GO:0051352)3.09568975
119negative regulation of mitotic sister chromatid separation (GO:2000816)3.08185928
120negative regulation of mitotic sister chromatid segregation (GO:0033048)3.08185928
121negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.08185928
122negative regulation of sister chromatid segregation (GO:0033046)3.08185928
123maturation of SSU-rRNA (GO:0030490)3.07151504
124male meiosis I (GO:0007141)3.06694940
125regulation of mitotic metaphase/anaphase transition (GO:0030071)3.06333367
126DNA synthesis involved in DNA repair (GO:0000731)3.05720790
127IMP metabolic process (GO:0046040)3.03137919
128positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.02908213
129positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.02908213
130positive regulation of mitotic sister chromatid separation (GO:1901970)3.02908213
131nucleotide-excision repair, DNA gap filling (GO:0006297)3.02812450
132DNA conformation change (GO:0071103)3.01068455
133telomere maintenance via telomere lengthening (GO:0010833)3.00585016
134mitochondrial RNA metabolic process (GO:0000959)2.99033855
135somatic diversification of immune receptors via somatic mutation (GO:0002566)2.98603681
136somatic hypermutation of immunoglobulin genes (GO:0016446)2.98603681
137G1/S transition of mitotic cell cycle (GO:0000082)2.98587749
138cell cycle G1/S phase transition (GO:0044843)2.98587749
139ribonucleoprotein complex biogenesis (GO:0022613)2.98322700
140meiotic cell cycle process (GO:1903046)2.98212218
141DNA catabolic process, exonucleolytic (GO:0000738)2.97943018
142ATP-dependent chromatin remodeling (GO:0043044)2.95653473
143chromosome segregation (GO:0007059)2.93214691
144negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.92768126
145protein localization to chromosome (GO:0034502)2.91597039

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.78211687
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse6.06824176
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.51899223
4MYC_18555785_ChIP-Seq_MESCs_Mouse4.14935971
5E2F4_17652178_ChIP-ChIP_JURKAT_Human4.03424843
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.32393704
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.29515579
8* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.87197786
9* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.75703011
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.65672325
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.64865578
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.61957711
13AR_21909140_ChIP-Seq_LNCAP_Human2.59644806
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.46543721
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.41429893
16* ETS1_20019798_ChIP-Seq_JURKAT_Human2.41098595
17JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.39134543
18NELFA_20434984_ChIP-Seq_ESCs_Mouse2.34610666
19* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.32697896
20XRN2_22483619_ChIP-Seq_HELA_Human2.26068077
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.21122238
22RBPJ_22232070_ChIP-Seq_NCS_Mouse2.18561498
23* MYCN_18555785_ChIP-Seq_MESCs_Mouse2.13980325
24HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.05485535
25* E2F1_21310950_ChIP-Seq_MCF-7_Human2.01772699
26* VDR_23849224_ChIP-Seq_CD4+_Human2.01543299
27PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.00185840
28* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.97094985
29DCP1A_22483619_ChIP-Seq_HELA_Human1.89213488
30FOXP3_21729870_ChIP-Seq_TREG_Human1.81515341
31POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.81191829
32* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.80169171
33GABP_19822575_ChIP-Seq_HepG2_Human1.80142325
34TTF2_22483619_ChIP-Seq_HELA_Human1.75965900
35CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.71498409
36ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.70300533
37EGR1_19374776_ChIP-ChIP_THP-1_Human1.68947289
38* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.66914171
39MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.65654752
40* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.61051518
41YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.59362541
42SALL1_21062744_ChIP-ChIP_HESCs_Human1.58071391
43ELK1_19687146_ChIP-ChIP_HELA_Human1.54293688
44THAP11_20581084_ChIP-Seq_MESCs_Mouse1.51330193
45KDM5A_27292631_Chip-Seq_BREAST_Human1.46401742
46NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.46013199
47ELF1_17652178_ChIP-ChIP_JURKAT_Human1.35850134
48* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.35611881
49PADI4_21655091_ChIP-ChIP_MCF-7_Human1.35139691
50FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.31599471
51ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.30909291
52NANOG_18555785_ChIP-Seq_MESCs_Mouse1.29027387
53CIITA_25753668_ChIP-Seq_RAJI_Human1.25801394
54* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.25778474
55STAT3_1855785_ChIP-Seq_MESCs_Mouse1.23164188
56* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.23140269
57* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.22975939
58SOX2_18555785_ChIP-Seq_MESCs_Mouse1.21104317
59E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.20919303
60SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.18097770
61* YY1_21170310_ChIP-Seq_MESCs_Mouse1.17772244
62CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.17175383
63TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.15523334
64HOXB4_20404135_ChIP-ChIP_EML_Mouse1.15219364
65SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.12066172
66DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.09037184
67MYC_22102868_ChIP-Seq_BL_Human1.08391727
68FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.07685666
69E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.07347060
70POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.05835465
71* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.00965742
72SRF_21415370_ChIP-Seq_HL-1_Mouse0.99807471
73NOTCH1_21737748_ChIP-Seq_TLL_Human0.98684861
74NANOG_16153702_ChIP-ChIP_HESCs_Human0.97374809
75TFEB_21752829_ChIP-Seq_HELA_Human0.97307795
76MYC_18940864_ChIP-ChIP_HL60_Human0.97062701
77CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.95803664
78EWS_26573619_Chip-Seq_HEK293_Human0.91676784
79ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.91231874
80BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.89928118
81NANOG_21062744_ChIP-ChIP_HESCs_Human0.89669338
82ERG_20887958_ChIP-Seq_HPC-7_Mouse0.88702067
83SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.87822212
84SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.87730699
85TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.87640904
86CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.86466321
87SOX2_16153702_ChIP-ChIP_HESCs_Human0.86307076
88TP63_19390658_ChIP-ChIP_HaCaT_Human0.86206506
89CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.85289300
90POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.85088394
91KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.84702589
92HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.84640592
93CHD1_26751641_Chip-Seq_LNCaP_Human0.83085510
94KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.82457672
95* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.82225313
96SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.78829954
97BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.78315910
98POU5F1_16153702_ChIP-ChIP_HESCs_Human0.76155959
99ZNF263_19887448_ChIP-Seq_K562_Human0.76042545
100SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.73786132
101* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.73736759
102* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.72983390
103FUS_26573619_Chip-Seq_HEK293_Human0.72256443
104TBX5_21415370_ChIP-Seq_HL-1_Mouse0.71905946
105PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.71345631
106NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.70950067
107TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.70250224
108DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.69710184
109ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.68755847
110CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.68014364
111ESR1_15608294_ChIP-ChIP_MCF-7_Human0.67826507
112SOX17_20123909_ChIP-Seq_XEN_Mouse0.64641603
113* PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.64189816
114NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.62300233

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization5.17516760
2MP0010094_abnormal_chromosome_stability4.68783243
3MP0008877_abnormal_DNA_methylation4.42571653
4MP0003693_abnormal_embryo_hatching4.39233254
5MP0008057_abnormal_DNA_replication4.10310517
6MP0003111_abnormal_nucleus_morphology3.99364281
7MP0004957_abnormal_blastocyst_morpholog3.93485006
8MP0003077_abnormal_cell_cycle3.64676918
9MP0008058_abnormal_DNA_repair3.52051770
10MP0008007_abnormal_cellular_replicative2.98433446
11MP0001929_abnormal_gametogenesis2.86536830
12MP0003123_paternal_imprinting2.65706307
13MP0003698_abnormal_male_reproductive2.61000414
14MP0002210_abnormal_sex_determination2.56847067
15MP0001730_embryonic_growth_arrest2.54274262
16MP0008932_abnormal_embryonic_tissue2.43848838
17MP0001188_hyperpigmentation2.25959044
18MP0001145_abnormal_male_reproductive2.21239216
19MP0009379_abnormal_foot_pigmentation2.16447058
20MP0010307_abnormal_tumor_latency2.14034431
21MP0010352_gastrointestinal_tract_polyps2.13407160
22MP0000350_abnormal_cell_proliferation2.05313748
23MP0003786_premature_aging2.01774963
24MP0002653_abnormal_ependyma_morphology1.93203586
25MP0000653_abnormal_sex_gland1.88053857
26MP0005380_embryogenesis_phenotype1.76898229
27MP0001672_abnormal_embryogenesis/_devel1.76898229
28MP0001697_abnormal_embryo_size1.75527737
29MP0003941_abnormal_skin_development1.68050236
30MP0003984_embryonic_growth_retardation1.62042258
31MP0002084_abnormal_developmental_patter1.61245618
32MP0004197_abnormal_fetal_growth/weight/1.59988480
33MP0002080_prenatal_lethality1.59176152
34MP0002088_abnormal_embryonic_growth/wei1.58156311
35MP0002161_abnormal_fertility/fecundity1.58021674
36MP0001529_abnormal_vocalization1.57947006
37MP0000537_abnormal_urethra_morphology1.56494949
38MP0002085_abnormal_embryonic_tissue1.54616979
39MP0003121_genomic_imprinting1.53466136
40MP0002160_abnormal_reproductive_system1.51998759
41MP0005187_abnormal_penis_morphology1.51462807
42MP0003890_abnormal_embryonic-extraembry1.44593517
43MP0010030_abnormal_orbit_morphology1.41192955
44MP0004808_abnormal_hematopoietic_stem1.39903917
45MP0002086_abnormal_extraembryonic_tissu1.34610161
46MP0002396_abnormal_hematopoietic_system1.33846958
47MP0001293_anophthalmia1.32339016
48MP0000313_abnormal_cell_death1.31481758
49MP0005076_abnormal_cell_differentiation1.28840458
50MP0005623_abnormal_meninges_morphology1.24788092
51MP0000647_abnormal_sebaceous_gland1.19713111
52MP0003567_abnormal_fetal_cardiomyocyte1.19651939
53MP0002938_white_spotting1.19269239
54MP0009053_abnormal_anal_canal1.18939384
55MP0003705_abnormal_hypodermis_morpholog1.16082607
56MP0006292_abnormal_olfactory_placode1.15251921
57MP0004233_abnormal_muscle_weight1.14867134
58MP0003186_abnormal_redox_activity1.12204886
59MP0004147_increased_porphyrin_level1.11276177
60MP0002019_abnormal_tumor_incidence1.10326032
61MP0000358_abnormal_cell_content/1.09821115
62MP0002282_abnormal_trachea_morphology1.08426062
63MP0003806_abnormal_nucleotide_metabolis1.03666555
64MP0000490_abnormal_crypts_of0.98996354
65MP0005389_reproductive_system_phenotype0.97734177
66MP0009672_abnormal_birth_weight0.97498510
67MP0003718_maternal_effect0.95302001
68MP0003315_abnormal_perineum_morphology0.91441803
69MP0008789_abnormal_olfactory_epithelium0.89202219
70MP0003119_abnormal_digestive_system0.87597818
71MP0003221_abnormal_cardiomyocyte_apopto0.87129460
72MP0006054_spinal_hemorrhage0.86758369
73MP0002877_abnormal_melanocyte_morpholog0.86372786
74MP0002009_preneoplasia0.85356381
75MP0004133_heterotaxia0.85022238
76MP0003115_abnormal_respiratory_system0.84401497
77MP0003937_abnormal_limbs/digits/tail_de0.80236202
78MP0005501_abnormal_skin_physiology0.79597902
79MP0003385_abnormal_body_wall0.79341078
80MP0009703_decreased_birth_body0.78994351
81MP0001119_abnormal_female_reproductive0.76687320
82MP0001545_abnormal_hematopoietic_system0.76321755
83MP0005397_hematopoietic_system_phenotyp0.76321755
84MP0002233_abnormal_nose_morphology0.75827826
85MP0003943_abnormal_hepatobiliary_system0.74940585
86MP0002092_abnormal_eye_morphology0.74901326
87MP0005499_abnormal_olfactory_system0.73566411
88MP0005394_taste/olfaction_phenotype0.73566411
89MP0001661_extended_life_span0.73271528
90MP0002796_impaired_skin_barrier0.70641630
91MP0005384_cellular_phenotype0.69663801
92MP0002697_abnormal_eye_size0.68826723
93MP0005409_darkened_coat_color0.67378979
94MP0001915_intracranial_hemorrhage0.67239911
95MP0002111_abnormal_tail_morphology0.66278908
96MP0000428_abnormal_craniofacial_morphol0.65597466
97MP0004084_abnormal_cardiac_muscle0.64811978
98MP0000703_abnormal_thymus_morphology0.64444231
99MP0003755_abnormal_palate_morphology0.64252252
100MP0000049_abnormal_middle_ear0.61978192
101MP0003861_abnormal_nervous_system0.61553005
102MP0002269_muscular_atrophy0.60120331
103MP0000432_abnormal_head_morphology0.59893484
104MP0005023_abnormal_wound_healing0.58690539
105MP0002751_abnormal_autonomic_nervous0.58660486
106MP0002177_abnormal_outer_ear0.58598639
107MP0001727_abnormal_embryo_implantation0.58022284
108MP0002095_abnormal_skin_pigmentation0.57265771
109MP0006072_abnormal_retinal_apoptosis0.57171579
110MP0000733_abnormal_muscle_development0.56687694
111MP0002081_perinatal_lethality0.56323683
112MP0005621_abnormal_cell_physiology0.56005502
113MP0008260_abnormal_autophagy0.54970232
114MP0001849_ear_inflammation0.53603305
115MP0003942_abnormal_urinary_system0.53221612
116MP0006035_abnormal_mitochondrial_morpho0.52392871
117MP0003699_abnormal_female_reproductive0.50806457
118MP0008995_early_reproductive_senescence0.50555426
119MP0002114_abnormal_axial_skeleton0.50231185
120MP0003566_abnormal_cell_adhesion0.48134919
121MP0005266_abnormal_metabolism0.47118576
122MP0006036_abnormal_mitochondrial_physio0.46986908
123MP0003935_abnormal_craniofacial_develop0.46804610
124MP0004264_abnormal_extraembryonic_tissu0.46545578
125MP0002925_abnormal_cardiovascular_devel0.46496001
126MP0001286_abnormal_eye_development0.46337578
127MP0000266_abnormal_heart_morphology0.45752401
128MP0003122_maternal_imprinting0.45309784
129MP0009697_abnormal_copulation0.45024043
130MP0002102_abnormal_ear_morphology0.43619384

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)7.19051628
2Dynein arm defect of respiratory motile cilia (HP:0012255)6.08570508
3Absent/shortened dynein arms (HP:0200106)6.08570508
4Abnormal respiratory motile cilium physiology (HP:0012261)4.54929195
5Abnormal respiratory motile cilium morphology (HP:0005938)4.50338565
6Abnormal respiratory epithelium morphology (HP:0012253)4.50338565
7Rhinitis (HP:0012384)4.29205638
8Chronic bronchitis (HP:0004469)4.21174233
9Degeneration of anterior horn cells (HP:0002398)4.09531100
10Abnormality of the anterior horn cell (HP:0006802)4.09531100
11Selective tooth agenesis (HP:0001592)3.94541251
12Abnormality of glycolysis (HP:0004366)3.72845828
13Increased serum pyruvate (HP:0003542)3.68457917
14Cortical dysplasia (HP:0002539)3.64399897
15Abnormal ciliary motility (HP:0012262)3.38626312
1611 pairs of ribs (HP:0000878)3.34695524
17Abnormality of the lower motor neuron (HP:0002366)3.33106623
18Birth length less than 3rd percentile (HP:0003561)3.20385876
19Impulsivity (HP:0100710)3.19315294
20Nasal polyposis (HP:0100582)3.07256890
21Infertility (HP:0000789)2.94006444
22Ependymoma (HP:0002888)2.90500029
23Colon cancer (HP:0003003)2.83243466
24Medulloblastoma (HP:0002885)2.78859866
25Hypoplasia of the capital femoral epiphysis (HP:0003090)2.76138840
26Chromsome breakage (HP:0040012)2.74827337
27Microvesicular hepatic steatosis (HP:0001414)2.72571152
28Abnormal spermatogenesis (HP:0008669)2.70465175
29Supernumerary spleens (HP:0009799)2.69789945
30Abnormality of chromosome stability (HP:0003220)2.69093644
31Gonadotropin excess (HP:0000837)2.68118629
32Nephronophthisis (HP:0000090)2.64158482
33Bronchitis (HP:0012387)2.61563114
34Facial cleft (HP:0002006)2.59794167
35Meckel diverticulum (HP:0002245)2.58157917
36Reticulocytopenia (HP:0001896)2.53061211
37Amyotrophic lateral sclerosis (HP:0007354)2.52817955
38Missing ribs (HP:0000921)2.49179753
39Abnormality of the ileum (HP:0001549)2.46186208
40Atrophy/Degeneration involving motor neurons (HP:0007373)2.45301095
41Aplasia/Hypoplasia of the uvula (HP:0010293)2.44768607
42Sloping forehead (HP:0000340)2.44507759
43Increased nuchal translucency (HP:0010880)2.43411230
44Chromosomal breakage induced by crosslinking agents (HP:0003221)2.42771735
45Abnormality of the preputium (HP:0100587)2.41576199
46Multiple enchondromatosis (HP:0005701)2.39315196
47Small intestinal stenosis (HP:0012848)2.39218899
48Duodenal stenosis (HP:0100867)2.39218899
49Breast hypoplasia (HP:0003187)2.38437701
50Facial hemangioma (HP:0000329)2.34986436
51Bronchiectasis (HP:0002110)2.33942684
52Ectopic kidney (HP:0000086)2.29671004
53Fibular hypoplasia (HP:0003038)2.27868103
54Nephroblastoma (Wilms tumor) (HP:0002667)2.27849005
55Abnormality of the nasal mucosa (HP:0000433)2.26694334
56Oral leukoplakia (HP:0002745)2.26554085
57Agnosia (HP:0010524)2.25349315
58Abnormality of cells of the erythroid lineage (HP:0012130)2.24018280
59Proximal placement of thumb (HP:0009623)2.22234097
60Acute encephalopathy (HP:0006846)2.21729720
61Acute necrotizing encephalopathy (HP:0006965)2.20393785
62Short ribs (HP:0000773)2.20102982
63Abnormal lung lobation (HP:0002101)2.19801929
64Abnormality of methionine metabolism (HP:0010901)2.17886918
65Embryonal renal neoplasm (HP:0011794)2.17487440
66Increased serum lactate (HP:0002151)2.16791327
67Absent thumb (HP:0009777)2.16715995
68Deviation of the thumb (HP:0009603)2.16005974
69Rhabdomyosarcoma (HP:0002859)2.15556746
70Postnatal microcephaly (HP:0005484)2.15171996
71Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.14394311
72Absent epiphyses (HP:0010577)2.14394311
73Patellar aplasia (HP:0006443)2.14103250
74Carpal bone hypoplasia (HP:0001498)2.13885310
75Horseshoe kidney (HP:0000085)2.13146223
76Overlapping toe (HP:0001845)2.12679033
77Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.12156510
78Abnormality of alanine metabolism (HP:0010916)2.12156510
79Hyperalaninemia (HP:0003348)2.12156510
80Abnormal number of erythroid precursors (HP:0012131)2.09886955
81Astrocytoma (HP:0009592)2.08597986
82Abnormality of the astrocytes (HP:0100707)2.08597986
83Neoplasm of the pancreas (HP:0002894)2.08124614
84Secondary amenorrhea (HP:0000869)2.04623708
85Breast carcinoma (HP:0003002)2.03083068
86High pitched voice (HP:0001620)2.03074639
87Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.02871047
88Decreased activity of mitochondrial respiratory chain (HP:0008972)2.02871047
89Shoulder girdle muscle weakness (HP:0003547)2.02734933
90Abnormal mitochondria in muscle tissue (HP:0008316)2.02653304
91Abnormality of the labia minora (HP:0012880)2.01319637
92Volvulus (HP:0002580)2.00390030
93Aplasia/Hypoplasia of the patella (HP:0006498)1.99510809
94Increased CSF lactate (HP:0002490)1.99100541
95Increased hepatocellular lipid droplets (HP:0006565)1.99023494
96Neoplasm of striated muscle (HP:0009728)1.96910461
97Myelodysplasia (HP:0002863)1.96121128
98Microglossia (HP:0000171)1.95922033
99Aplasia involving forearm bones (HP:0009822)1.95318404
100Absent forearm bone (HP:0003953)1.95318404
101Biliary tract neoplasm (HP:0100574)1.93574746
102Cerebral edema (HP:0002181)1.91525431
103Pelvic girdle muscle weakness (HP:0003749)1.91401779
104Macrocytic anemia (HP:0001972)1.90143774
105Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.89241078
106Short 4th metacarpal (HP:0010044)1.89241078
107Triphalangeal thumb (HP:0001199)1.88744828
108Abnormality of the duodenum (HP:0002246)1.88598149
109Abnormality of abdominal situs (HP:0011620)1.88325013
110Abdominal situs inversus (HP:0003363)1.88325013
111Atresia of the external auditory canal (HP:0000413)1.86381423
112Upper motor neuron abnormality (HP:0002127)1.85989756
113Choanal atresia (HP:0000453)1.85308671
114Absent radius (HP:0003974)1.83952569
115Abnormality of the carotid arteries (HP:0005344)1.83848226
116Premature ovarian failure (HP:0008209)1.81609382
117Glioma (HP:0009733)1.81589969
118Aplasia/Hypoplasia of the sternum (HP:0006714)1.81378504
119Basal cell carcinoma (HP:0002671)1.80348325
120Progressive external ophthalmoplegia (HP:0000590)1.79235892
121Trismus (HP:0000211)1.78845511
122Abnormality of the renal medulla (HP:0100957)1.78104618
123Arteriovenous malformation (HP:0100026)1.77876258
124Ovarian neoplasm (HP:0100615)1.77687505
125Prominent nose (HP:0000448)1.75951768
126Type I transferrin isoform profile (HP:0003642)1.75253837
127Aplasia/hypoplasia of the humerus (HP:0006507)1.73902501
128Spastic diplegia (HP:0001264)1.73664287
129Cerebral hypomyelination (HP:0006808)1.72943357
130Broad distal phalanx of finger (HP:0009836)1.72477880
131Neoplasm of the colon (HP:0100273)1.71945875
132Pancytopenia (HP:0001876)1.70420171
133Aplasia/Hypoplasia of the fibula (HP:0006492)1.69790039
134Hypoplasia of the radius (HP:0002984)1.69681881
135Abnormal gallbladder physiology (HP:0012438)1.69388141
136Cholecystitis (HP:0001082)1.69388141
137Cafe-au-lait spot (HP:0000957)1.69367830
138Lactic acidosis (HP:0003128)1.68672349
139Lipid accumulation in hepatocytes (HP:0006561)1.67852453
140Papillary thyroid carcinoma (HP:0002895)1.66361578
141Progressive macrocephaly (HP:0004481)1.65909233
142Abnormality of serum amino acid levels (HP:0003112)1.65087647
143Aplasia/Hypoplasia of the sacrum (HP:0008517)1.64066077
144CNS hypomyelination (HP:0003429)1.63506879
145Abnormal umbilical cord blood vessels (HP:0011403)1.63492402
146Single umbilical artery (HP:0001195)1.63492402
147Abnormality of the fetal cardiovascular system (HP:0010948)1.63492402
148Abnormality of the hip-girdle musculature (HP:0001445)1.62717516
149Abnormality of the musculature of the pelvis (HP:0001469)1.62717516
150Embryonal neoplasm (HP:0002898)1.59527271
151Reduced antithrombin III activity (HP:0001976)1.58952163
152Progressive muscle weakness (HP:0003323)1.54739762
153Megaloblastic anemia (HP:0001889)1.54107043
154Leukodystrophy (HP:0002415)1.53946281

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK45.05072185
2PDK35.05072185
3CDC74.34780252
4WEE13.81142518
5BUB13.51830997
6NEK23.10058322
7PDK23.02297985
8TESK12.65697141
9EIF2AK12.62132210
10TRIM282.37954300
11NEK12.33414280
12PASK2.29716217
13TTK2.18869528
14SRPK12.11211907
15TSSK62.10751464
16BRSK21.99859437
17MST41.90732331
18ACVR1B1.89257879
19PLK11.81502260
20PNCK1.79219988
21PLK41.73154636
22ATR1.73124452
23VRK21.62474369
24TESK21.55534595
25PLK31.53701994
26MKNK11.52824542
27CCNB11.43967461
28EIF2AK31.42599910
29AURKB1.39680441
30EEF2K1.36498672
31CDK121.36461783
32SCYL21.35731180
33CHEK11.34368825
34DYRK31.33577400
35CHEK21.31887917
36NUAK11.28059397
37BRSK11.19853812
38CDK71.18686744
39TAF11.18629248
40BCR1.18547248
41STK161.18492650
42TGFBR11.14465392
43RPS6KB21.09168990
44RPS6KA41.04509007
45NME11.04098075
46AURKA1.02929547
47MAP3K81.01886262
48CDK41.01689545
49VRK11.01354673
50STK30.99024234
51PKN20.97769601
52ATM0.97465409
53MKNK20.96165258
54PAK40.95137225
55TLK10.92432820
56MAP3K100.87984566
57STK100.85396438
58ICK0.85172048
59CDK20.75521415
60MAPKAPK50.71706264
61PRKD30.71252175
62CSNK1G10.70220692
63CSNK1G30.69229630
64ERBB40.68111085
65ZAK0.66962013
66STK40.66745074
67PAK10.66737686
68EPHA20.65255344
69PTK2B0.63904249
70STK390.63850767
71PLK20.62157660
72CDK10.61879507
73CSNK2A20.61393347
74STK38L0.61199433
75NME20.60156027
76CLK10.59177901
77CDK190.59001018
78RAF10.56493699
79CDK60.54493903
80CSNK2A10.52672610
81CSNK1A1L0.52574003
82BRAF0.52507093
83BRD40.52497058
84CSNK1G20.50877516
85MTOR0.50815899
86MELK0.49900401
87WNK30.49003899
88ALK0.48469216
89LIMK10.47660074
90MINK10.47315332
91CDK30.45843459
92FGFR10.43884580
93PAK20.43256363
94KSR10.43244566
95SMG10.43086739
96MAP3K40.42724356
97FLT30.42191837
98LRRK20.40958528
99CDK11A0.40725805
100PIM10.40389077
101CSNK1E0.37866348
102PRKDC0.37275426
103TTN0.35743452
104PBK0.34044998
105MET0.31911624
106RPS6KB10.31884883
107TRIB30.31225789
108PRKCI0.30947483
109MAP3K90.29493966
110DAPK10.29066495
111DYRK1B0.27153652
112EIF2AK20.26385110
113CDK80.25239472
114ILK0.23945197
115CSNK1D0.22825838
116LATS10.21718176
117WNK40.20142678
118RPS6KA50.19736960
119AKT20.19717737
120ERBB30.18572746
121LATS20.18308711
122MAPKAPK30.17660902
123NEK90.17120811
124MAPK140.15551201
125CDK140.14980446
126CDK180.14633742
127CDK150.14030715
128MAP2K30.13968374

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.70380873
2Mismatch repair_Homo sapiens_hsa034304.08802053
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.67645773
4RNA transport_Homo sapiens_hsa030133.65154340
5Proteasome_Homo sapiens_hsa030503.30275074
6Spliceosome_Homo sapiens_hsa030403.24110179
7Cell cycle_Homo sapiens_hsa041102.91663916
8Homologous recombination_Homo sapiens_hsa034402.83786850
9Nucleotide excision repair_Homo sapiens_hsa034202.81735561
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.80494534
11Base excision repair_Homo sapiens_hsa034102.74287021
12Fanconi anemia pathway_Homo sapiens_hsa034602.62334825
13One carbon pool by folate_Homo sapiens_hsa006702.54652987
14Basal transcription factors_Homo sapiens_hsa030222.36729872
15Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.26259677
16RNA polymerase_Homo sapiens_hsa030202.23690474
17Ribosome_Homo sapiens_hsa030102.22852846
18mRNA surveillance pathway_Homo sapiens_hsa030152.20547425
19Pyrimidine metabolism_Homo sapiens_hsa002402.11848034
20Non-homologous end-joining_Homo sapiens_hsa034502.09235160
21RNA degradation_Homo sapiens_hsa030181.92570186
22Oocyte meiosis_Homo sapiens_hsa041141.66316957
23Vitamin B6 metabolism_Homo sapiens_hsa007501.64019151
24Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.58601865
25Selenocompound metabolism_Homo sapiens_hsa004501.55135661
26Systemic lupus erythematosus_Homo sapiens_hsa053221.52892511
27Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.47536496
28p53 signaling pathway_Homo sapiens_hsa041151.47041656
29Pentose phosphate pathway_Homo sapiens_hsa000301.43638826
30Steroid biosynthesis_Homo sapiens_hsa001001.38366347
31Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.34068529
32Biosynthesis of amino acids_Homo sapiens_hsa012301.33720703
33Cysteine and methionine metabolism_Homo sapiens_hsa002701.32879756
34Pyruvate metabolism_Homo sapiens_hsa006201.30707087
35Purine metabolism_Homo sapiens_hsa002301.30452851
36Epstein-Barr virus infection_Homo sapiens_hsa051691.20924546
37Viral carcinogenesis_Homo sapiens_hsa052031.14502685
38Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.13586599
39Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.13522148
40Carbon metabolism_Homo sapiens_hsa012001.12018484
41Antigen processing and presentation_Homo sapiens_hsa046121.04419634
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.04175248
43Oxidative phosphorylation_Homo sapiens_hsa001901.01678941
44Folate biosynthesis_Homo sapiens_hsa007901.01283544
45Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.99852880
46Fatty acid elongation_Homo sapiens_hsa000620.94258382
47Huntingtons disease_Homo sapiens_hsa050160.87909361
48Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.80899099
49HTLV-I infection_Homo sapiens_hsa051660.80063548
50Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.78648491
51Legionellosis_Homo sapiens_hsa051340.67864726
52Herpes simplex infection_Homo sapiens_hsa051680.63703607
53Alcoholism_Homo sapiens_hsa050340.63263367
54Glucagon signaling pathway_Homo sapiens_hsa049220.63085234
55Central carbon metabolism in cancer_Homo sapiens_hsa052300.62498710
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.61968460
57Fatty acid metabolism_Homo sapiens_hsa012120.58294997
58Arginine and proline metabolism_Homo sapiens_hsa003300.57718627
59Fructose and mannose metabolism_Homo sapiens_hsa000510.56125475
60N-Glycan biosynthesis_Homo sapiens_hsa005100.55455943
61Glutathione metabolism_Homo sapiens_hsa004800.54095753
62Propanoate metabolism_Homo sapiens_hsa006400.53735742
63Small cell lung cancer_Homo sapiens_hsa052220.53674021
64Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.52564121
65Alzheimers disease_Homo sapiens_hsa050100.52327549
66Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.51679201
67Cyanoamino acid metabolism_Homo sapiens_hsa004600.51240776
68Thyroid cancer_Homo sapiens_hsa052160.50752336
69MicroRNAs in cancer_Homo sapiens_hsa052060.50322584
70Hippo signaling pathway_Homo sapiens_hsa043900.48758249
712-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.48721398
72Basal cell carcinoma_Homo sapiens_hsa052170.47777745
73Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.46285225
74TGF-beta signaling pathway_Homo sapiens_hsa043500.42176012
75Drug metabolism - other enzymes_Homo sapiens_hsa009830.39083067
76HIF-1 signaling pathway_Homo sapiens_hsa040660.38048392
77Hedgehog signaling pathway_Homo sapiens_hsa043400.34112318
78Fatty acid degradation_Homo sapiens_hsa000710.33180045
79Sulfur metabolism_Homo sapiens_hsa009200.32857487
80beta-Alanine metabolism_Homo sapiens_hsa004100.32749703
81Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.31303435
82Colorectal cancer_Homo sapiens_hsa052100.30125553
83Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.30034672
84Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.27670642
85Renin-angiotensin system_Homo sapiens_hsa046140.26388104
86Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.24780296
87Adherens junction_Homo sapiens_hsa045200.23959311
88Transcriptional misregulation in cancer_Homo sapiens_hsa052020.23429352
89mTOR signaling pathway_Homo sapiens_hsa041500.23180462
90Arginine biosynthesis_Homo sapiens_hsa002200.23089508
91Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.22244956
92Vibrio cholerae infection_Homo sapiens_hsa051100.21551004
93Tight junction_Homo sapiens_hsa045300.21105197
94Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.20911902
95Pentose and glucuronate interconversions_Homo sapiens_hsa000400.20166090
96Protein export_Homo sapiens_hsa030600.20086941
97Butanoate metabolism_Homo sapiens_hsa006500.19507615
98Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.18293524
99Shigellosis_Homo sapiens_hsa051310.18111161
100Wnt signaling pathway_Homo sapiens_hsa043100.17835195
101Metabolic pathways_Homo sapiens_hsa011000.16875509
102Viral myocarditis_Homo sapiens_hsa054160.16490603
103Bladder cancer_Homo sapiens_hsa052190.16109548
104Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.15109293
105Apoptosis_Homo sapiens_hsa042100.13879071
106Parkinsons disease_Homo sapiens_hsa050120.12927232
107Pathways in cancer_Homo sapiens_hsa052000.12421196
108Peroxisome_Homo sapiens_hsa041460.12029720
109AMPK signaling pathway_Homo sapiens_hsa041520.11964861
110Chronic myeloid leukemia_Homo sapiens_hsa052200.11190554
111Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.10226714
112Lysine degradation_Homo sapiens_hsa003100.09664764
113Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.09638912
114Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.09509965
115Hepatitis B_Homo sapiens_hsa051610.08256251
116Thyroid hormone signaling pathway_Homo sapiens_hsa049190.08110993
117Prostate cancer_Homo sapiens_hsa052150.08076013
118Influenza A_Homo sapiens_hsa051640.07972105
119Linoleic acid metabolism_Homo sapiens_hsa005910.06670315
120Fatty acid biosynthesis_Homo sapiens_hsa000610.05912145
121Galactose metabolism_Homo sapiens_hsa000520.04788617
122Fat digestion and absorption_Homo sapiens_hsa049750.04566564
123Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.04023850
124Sulfur relay system_Homo sapiens_hsa041220.03715951

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