ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	pyrimidine nucleobase catabolic process (GO:0006208)	6.26825887
2	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	5.28327579
3	substrate-independent telencephalic tangential migration (GO:0021826)	5.28327579
4	neuronal ion channel clustering (GO:0045161)	5.16183443
5	sperm motility (GO:0030317)	5.07196007
6	protein polyglutamylation (GO:0018095)	4.96997047
7	behavioral response to nicotine (GO:0035095)	4.86955973
8	nucleobase catabolic process (GO:0046113)	4.82066688
9	acrosome reaction (GO:0007340)	4.75276369
10	regulation of cilium movement (GO:0003352)	4.47590482
11	neurofilament cytoskeleton organization (GO:0060052)	4.34117204
12	cranial nerve morphogenesis (GO:0021602)	4.21273039
13	response to pheromone (GO:0019236)	4.09916075
14	transmission of nerve impulse (GO:0019226)	4.07945500
15	neuron recognition (GO:0008038)	4.05805290
16	peristalsis (GO:0030432)	4.04919594
17	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	3.98601071
18	regulation of synapse structural plasticity (GO:0051823)	3.87027213
19	presynaptic membrane organization (GO:0097090)	3.82871800
20	calcium ion-dependent exocytosis (GO:0017156)	3.77661344
21	establishment of mitochondrion localization (GO:0051654)	3.75428542
22	urogenital system development (GO:0001655)	3.74427700
23	single strand break repair (GO:0000012)	3.68618490
24	forebrain neuron differentiation (GO:0021879)	3.67053957
25	microtubule severing (GO:0051013)	3.66432858
26	synaptic transmission, dopaminergic (GO:0001963)	3.64578059
27	cell migration in hindbrain (GO:0021535)	3.60596101
28	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	3.59911019
29	regulation of microtubule-based movement (GO:0060632)	3.57337047
30	axonal fasciculation (GO:0007413)	3.54794824
31	locomotory exploration behavior (GO:0035641)	3.52274140
32	positive regulation of growth hormone secretion (GO:0060124)	3.46801179
33	mitochondrion transport along microtubule (GO:0047497)	3.38399064
34	establishment of mitochondrion localization, microtubule-mediated (GO:0034643)	3.38399064
35	neurotransmitter-gated ion channel clustering (GO:0072578)	3.32893712
36	response to acidic pH (GO:0010447)	3.28677331
37	brain morphogenesis (GO:0048854)	3.24950220
38	phenylpropanoid metabolic process (GO:0009698)	3.24826708
39	negative regulation of catecholamine secretion (GO:0033604)	3.21268575
40	neuromuscular synaptic transmission (GO:0007274)	3.08070978
41	axonemal dynein complex assembly (GO:0070286)	3.04558544
42	microtubule depolymerization (GO:0007019)	3.01986735
43	cellular ketone body metabolic process (GO:0046950)	3.00147914
44	epithelial cilium movement (GO:0003351)	2.99736285
45	neural tube formation (GO:0001841)	2.97492110
46	glucocorticoid biosynthetic process (GO:0006704)	2.97309673
47	sperm-egg recognition (GO:0035036)	2.94287955
48	pattern specification involved in kidney development (GO:0061004)	2.93839480
49	spermatid development (GO:0007286)	2.93375757
50	regulation of neuron migration (GO:2001222)	2.91726109
51	spinal cord association neuron differentiation (GO:0021527)	2.91335689
52	neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)	2.88586833
53	protein targeting to Golgi (GO:0000042)	2.87884039
54	cerebral cortex radially oriented cell migration (GO:0021799)	2.87433223
55	cranial nerve structural organization (GO:0021604)	2.86341049
56	regulation of dopamine secretion (GO:0014059)	2.84815141
57	spermatid nucleus differentiation (GO:0007289)	2.84808956
58	glutamate secretion (GO:0014047)	2.84402916
59	protein localization to synapse (GO:0035418)	2.84180097
60	microtubule bundle formation (GO:0001578)	2.82385085
61	multicellular organism reproduction (GO:0032504)	2.82354867
62	synapse assembly (GO:0007416)	2.81948715
63	cellular response to pH (GO:0071467)	2.77992444
64	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	2.75202277
65	retinal ganglion cell axon guidance (GO:0031290)	2.74807516
66	establishment of protein localization to Golgi (GO:0072600)	2.74687945
67	cerebellar Purkinje cell differentiation (GO:0021702)	2.74013433
68	postsynaptic membrane organization (GO:0001941)	2.73370034
69	response to muscle activity (GO:0014850)	2.72848894
70	prepulse inhibition (GO:0060134)	2.72432310
71	fusion of sperm to egg plasma membrane (GO:0007342)	2.72132535
72	regulation of growth hormone secretion (GO:0060123)	2.71230665
73	metanephric mesenchyme development (GO:0072075)	2.70577524
74	dendritic spine morphogenesis (GO:0060997)	2.69090591
75	tachykinin receptor signaling pathway (GO:0007217)	2.69014619
76	synaptic vesicle maturation (GO:0016188)	2.68028288
77	cell proliferation in forebrain (GO:0021846)	2.67491479
78	parturition (GO:0007567)	2.67334877
79	sperm capacitation (GO:0048240)	2.67017242
80	central nervous system myelination (GO:0022010)	2.66298821
81	axon ensheathment in central nervous system (GO:0032291)	2.66298821
82	exploration behavior (GO:0035640)	2.64777937
83	binding of sperm to zona pellucida (GO:0007339)	2.64441015
84	microtubule polymerization or depolymerization (GO:0031109)	2.63793978
85	auditory behavior (GO:0031223)	2.63538682
86	C4-dicarboxylate transport (GO:0015740)	2.60893847
87	regulation of circadian sleep/wake cycle (GO:0042749)	2.60514288
88	regulation of circadian sleep/wake cycle, sleep (GO:0045187)	2.60514288
89	ketone body metabolic process (GO:1902224)	2.60090237
90	positive regulation of gastrulation (GO:2000543)	2.58436494
91	cranial nerve development (GO:0021545)	2.58046686
92	protein localization to Golgi apparatus (GO:0034067)	2.57335366
93	dendrite development (GO:0016358)	2.56251600
94	negative regulation of neurotransmitter secretion (GO:0046929)	2.56035017
95	cilium movement (GO:0003341)	2.53213002
96	mesonephros development (GO:0001823)	2.52746089
97	positive regulation of potassium ion transmembrane transporter activity (GO:1901018)	2.52181313
98	olfactory bulb development (GO:0021772)	2.52152216
99	establishment of monopolar cell polarity (GO:0061162)	2.51851580
100	establishment or maintenance of monopolar cell polarity (GO:0061339)	2.51851580

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	7.35272079
2	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	5.33346702
3	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	4.78262379
4	ZNF274_21170338_ChIP-Seq_K562_Hela	2.87610929
5	REST_21632747_ChIP-Seq_MESCs_Mouse	2.66757171
6	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	2.43415042
7	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.36599880
8	REST_18959480_ChIP-ChIP_MESCs_Mouse	2.27514318
9	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.23654559
10	SUZ12_27294783_Chip-Seq_ESCs_Mouse	2.22685093
11	EZH2_27294783_Chip-Seq_ESCs_Mouse	2.18692304
12	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.04982231
13	JARID2_20064375_ChIP-Seq_MESCs_Mouse	2.04268025
14	IKZF1_21737484_ChIP-ChIP_HCT116_Human	2.03011228
15	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.99361134
16	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.91741357
17	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.80714641
18	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.79718290
19	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.75907954
20	* CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.74959577
21	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.72413512
22	DROSHA_22980978_ChIP-Seq_HELA_Human	1.68103822
23	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.68052316
24	CTCF_27219007_Chip-Seq_Bcells_Human	1.65586507
25	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.65085933
26	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.65085933
27	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.63639567
28	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.63639567
29	RNF2_27304074_Chip-Seq_NSC_Mouse	1.59856062
30	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.58604551
31	GBX2_23144817_ChIP-Seq_PC3_Human	1.55027630
32	IRF1_19129219_ChIP-ChIP_H3396_Human	1.52469865
33	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.51531796
34	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.50774956
35	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.50319045
36	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	1.44408684
37	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.42763908
38	VDR_22108803_ChIP-Seq_LS180_Human	1.42554307
39	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.40622951
40	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.40492008
41	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.38746454
42	ERA_21632823_ChIP-Seq_H3396_Human	1.37942183
43	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.37082823
44	FUS_26573619_Chip-Seq_HEK293_Human	1.34324929
45	OLIG2_26023283_ChIP-Seq_AINV15_Mouse	1.33018975
46	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.31256985
47	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.29226436
48	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.27866006
49	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.24190455
50	P300_19829295_ChIP-Seq_ESCs_Human	1.20773544
51	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.20472569
52	CBP_20019798_ChIP-Seq_JUKART_Human	1.20472569
53	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.15282411
54	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.13987051
55	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.11283378
56	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.11004788
57	NCOR_22424771_ChIP-Seq_293T_Human	1.10566683
58	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.07751433
59	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.07131333
60	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.05777226
61	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.04545291
62	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.03099548
63	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.02670737
64	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.01615441
65	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.01092854
66	* DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.00311997
67	NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse	0.98473885
68	RARB_27405468_Chip-Seq_BRAIN_Mouse	0.98250585
69	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.98062027
70	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.97858912
71	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.97725426
72	ER_23166858_ChIP-Seq_MCF-7_Human	0.97418614
73	RAC3_21632823_ChIP-Seq_H3396_Human	0.96744903
74	* OCT4_19829295_ChIP-Seq_ESCs_Human	0.95760091
75	NANOG_20526341_ChIP-Seq_ESCs_Human	0.94409835
76	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.93637562
77	TP53_20018659_ChIP-ChIP_R1E_Mouse	0.93411610
78	OCT4_20526341_ChIP-Seq_ESCs_Human	0.93269469
79	TAF2_19829295_ChIP-Seq_ESCs_Human	0.92223604
80	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.91599894
81	PHF8_20622854_ChIP-Seq_HELA_Human	0.91519329
82	ELF1_20517297_ChIP-Seq_JURKAT_Human	0.91098090
83	ERG_21242973_ChIP-ChIP_JURKAT_Human	0.89410052
84	E2F1_20622854_ChIP-Seq_HELA_Human	0.89296269
85	MYC_19829295_ChIP-Seq_ESCs_Human	0.89251974
86	MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse	0.88452824
87	SMAD3_21741376_ChIP-Seq_ESCs_Human	0.87154681
88	* E2F1_17053090_ChIP-ChIP_MCF-7_Human	0.86905009
89	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.86809195
90	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	0.86630864
91	AR_25329375_ChIP-Seq_VCAP_Human	0.86614101
92	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.84955734
93	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.84843555
94	CTCF_20526341_ChIP-Seq_ESCs_Human	0.83863319
95	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	0.83223059
96	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.81680524
97	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	0.80206613
98	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	0.80174965
99	TP53_22573176_ChIP-Seq_HFKS_Human	0.80099603
100	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.78966376

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003880_abnormal_central_pattern	5.64520562
2	MP0006276_abnormal_autonomic_nervous	4.63332477
3	MP0002822_catalepsy	3.70847716
4	MP0005423_abnormal_somatic_nervous	3.47903315
5	MP0002653_abnormal_ependyma_morphology	3.32563445
6	MP0005410_abnormal_fertilization	3.11184945
7	MP0000778_abnormal_nervous_system	2.69775814
8	MP0003787_abnormal_imprinting	2.53062979
9	MP0001529_abnormal_vocalization	2.27813092
10	MP0004859_abnormal_synaptic_plasticity	2.24876536
11	MP0005394_taste/olfaction_phenotype	2.19051300
12	MP0005499_abnormal_olfactory_system	2.19051300
13	MP0002163_abnormal_gland_morphology	2.01292275
14	MP0000955_abnormal_spinal_cord	1.97387154
15	MP0008789_abnormal_olfactory_epithelium	1.96680316
16	MP0001188_hyperpigmentation	1.94636146
17	MP0001486_abnormal_startle_reflex	1.80827060
18	MP0003123_paternal_imprinting	1.78387358
19	MP0002272_abnormal_nervous_system	1.76297572
20	MP0002184_abnormal_innervation	1.64593404
21	MP0003635_abnormal_synaptic_transmissio	1.64551663
22	MP0004270_analgesia	1.63470157
23	MP0003011_delayed_dark_adaptation	1.60810596
24	MP0001984_abnormal_olfaction	1.60391650
25	MP0002160_abnormal_reproductive_system	1.58171660
26	MP0002557_abnormal_social/conspecific_i	1.57492266
27	MP0003646_muscle_fatigue	1.50676236
28	MP0003698_abnormal_male_reproductive	1.50226318
29	MP0002063_abnormal_learning/memory/cond	1.50012572
30	MP0009745_abnormal_behavioral_response	1.46904250
31	MP0005646_abnormal_pituitary_gland	1.46277808
32	MP0002572_abnormal_emotion/affect_behav	1.44150943
33	MP0004811_abnormal_neuron_physiology	1.43954251
34	MP0001968_abnormal_touch/_nociception	1.41803842
35	MP0006292_abnormal_olfactory_placode	1.40763805
36	MP0002882_abnormal_neuron_morphology	1.40732378
37	MP0005379_endocrine/exocrine_gland_phen	1.37439648
38	MP0001485_abnormal_pinna_reflex	1.37115182
39	MP0003315_abnormal_perineum_morphology	1.33050167
40	MP0003890_abnormal_embryonic-extraembry	1.32552238
41	MP0009046_muscle_twitch	1.31234623
42	MP0002752_abnormal_somatic_nervous	1.29703609
43	MP0002909_abnormal_adrenal_gland	1.29148553
44	MP0001905_abnormal_dopamine_level	1.28480745
45	MP0005551_abnormal_eye_electrophysiolog	1.28256036
46	MP0002837_dystrophic_cardiac_calcinosis	1.23040650
47	MP0003121_genomic_imprinting	1.21499736
48	MP0002067_abnormal_sensory_capabilities	1.17883443
49	MP0005386_behavior/neurological_phenoty	1.17488837
50	MP0004924_abnormal_behavior	1.17488837
51	MP0002734_abnormal_mechanical_nocicepti	1.16163223
52	MP0002733_abnormal_thermal_nociception	1.15523463
53	MP0005360_urolithiasis	1.15446929
54	MP0003879_abnormal_hair_cell	1.15309342
55	MP0004145_abnormal_muscle_electrophysio	1.15153249
56	MP0001970_abnormal_pain_threshold	1.13573419
57	MP0002064_seizures	1.11966035
58	MP0005187_abnormal_penis_morphology	1.10552780
59	MP0004742_abnormal_vestibular_system	1.10052684
60	MP0005377_hearing/vestibular/ear_phenot	1.09087526
61	MP0003878_abnormal_ear_physiology	1.09087526
62	MP0005389_reproductive_system_phenotype	1.06396582
63	MP0003861_abnormal_nervous_system	1.06104880
64	MP0001929_abnormal_gametogenesis	1.05643787
65	MP0002751_abnormal_autonomic_nervous	1.05443163
66	MP0010386_abnormal_urinary_bladder	1.05334869
67	MP0000534_abnormal_ureter_morphology	1.04178238
68	MP0002152_abnormal_brain_morphology	1.01314269
69	MP0001299_abnormal_eye_distance/	1.00433785
70	MP0002736_abnormal_nociception_after	0.99885960
71	MP0002735_abnormal_chemical_nociception	0.97395140
72	MP0002210_abnormal_sex_determination	0.93559779
73	MP0008995_early_reproductive_senescence	0.92969575
74	MP0008877_abnormal_DNA_methylation	0.90406687
75	MP0002229_neurodegeneration	0.88911341
76	MP0002638_abnormal_pupillary_reflex	0.86895549
77	MP0004142_abnormal_muscle_tone	0.86758118
78	MP0002161_abnormal_fertility/fecundity	0.85811058
79	MP0003122_maternal_imprinting	0.82749001
80	MP0001919_abnormal_reproductive_system	0.81862072
81	MP0001440_abnormal_grooming_behavior	0.80789725
82	MP0004085_abnormal_heartbeat	0.80635650
83	MP0004133_heterotaxia	0.79614200
84	MP0005195_abnormal_posterior_eye	0.79365532
85	MP0005645_abnormal_hypothalamus_physiol	0.79140508
86	MP0004134_abnormal_chest_morphology	0.78191808
87	MP0002066_abnormal_motor_capabilities/c	0.78036131
88	MP0000026_abnormal_inner_ear	0.77619354
89	MP0003938_abnormal_ear_development	0.77013129
90	MP0000631_abnormal_neuroendocrine_gland	0.76157203
91	MP0003942_abnormal_urinary_system	0.74457301
92	MP0001145_abnormal_male_reproductive	0.74384291
93	MP0002876_abnormal_thyroid_physiology	0.73795277
94	MP0004782_abnormal_surfactant_physiolog	0.73478647
95	MP0003718_maternal_effect	0.72657021
96	MP0000566_synostosis	0.72422271
97	MP0006072_abnormal_retinal_apoptosis	0.70562292
98	MP0000653_abnormal_sex_gland	0.70399002
99	MP0002234_abnormal_pharynx_morphology	0.69374097
100	MP0003119_abnormal_digestive_system	0.69088201

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Myokymia (HP:0002411)	4.23522119
2	Oligodactyly (hands) (HP:0001180)	3.66155223
3	Abnormality of macular pigmentation (HP:0008002)	3.59366805
4	Chronic hepatic failure (HP:0100626)	3.55682820
5	Thoracolumbar scoliosis (HP:0002944)	3.35081853
6	Hepatoblastoma (HP:0002884)	3.13018860
7	Abnormal pancreas size (HP:0012094)	3.10375510
8	Bony spicule pigmentary retinopathy (HP:0007737)	3.03914331
9	Progressive cerebellar ataxia (HP:0002073)	3.01872474
10	Supranuclear gaze palsy (HP:0000605)	2.92706051
11	Pancreatic fibrosis (HP:0100732)	2.82941306
12	Severe visual impairment (HP:0001141)	2.81974481
13	Optic nerve coloboma (HP:0000588)	2.81789333
14	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.78256272
15	Fetal akinesia sequence (HP:0001989)	2.75767693
16	Diastasis recti (HP:0001540)	2.74883150
17	Hyperthyroidism (HP:0000836)	2.69357298
18	Rib fusion (HP:0000902)	2.62685130
19	Occipital encephalocele (HP:0002085)	2.60996530
20	Spastic tetraplegia (HP:0002510)	2.59690025
21	Impulsivity (HP:0100710)	2.58719280
22	Gait imbalance (HP:0002141)	2.57270175
23	Facial shape deformation (HP:0011334)	2.57237910
24	Potter facies (HP:0002009)	2.57237910
25	Pancreatic cysts (HP:0001737)	2.56229538
26	True hermaphroditism (HP:0010459)	2.47570831
27	Medial flaring of the eyebrow (HP:0010747)	2.46423483
28	Sclerocornea (HP:0000647)	2.46420157
29	Abnormal respiratory motile cilium physiology (HP:0012261)	2.43522513
30	Abnormality of the corticospinal tract (HP:0002492)	2.39869087
31	Vaginal atresia (HP:0000148)	2.38321390
32	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	2.36356276
33	Oligodactyly (HP:0012165)	2.34139340
34	Tubulointerstitial nephritis (HP:0001970)	2.33877257
35	Renal dysplasia (HP:0000110)	2.33604420
36	Nephronophthisis (HP:0000090)	2.32821592
37	Growth hormone deficiency (HP:0000824)	2.31577544
38	Drooling (HP:0002307)	2.30647363
39	Focal motor seizures (HP:0011153)	2.29934405
40	Genital tract atresia (HP:0001827)	2.28909790
41	Congenital primary aphakia (HP:0007707)	2.28383556
42	Cortical dysplasia (HP:0002539)	2.27156351
43	Abnormality of the aortic arch (HP:0012303)	2.25811104
44	Hypoplasia of the brainstem (HP:0002365)	2.23440342
45	Aplasia/Hypoplasia of the brainstem (HP:0007362)	2.23440342
46	Osteomalacia (HP:0002749)	2.23150160
47	Poor coordination (HP:0002370)	2.23058256
48	Nephrogenic diabetes insipidus (HP:0009806)	2.22898909
49	Anencephaly (HP:0002323)	2.22790134
50	Double outlet right ventricle (HP:0001719)	2.18010431
51	Congenital malformation of the right heart (HP:0011723)	2.18010431
52	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.15458403
53	Absent/shortened dynein arms (HP:0200106)	2.15458403
54	Abnormality of the labia minora (HP:0012880)	2.14100258
55	Abnormal respiratory motile cilium morphology (HP:0005938)	2.10942455
56	Abnormal respiratory epithelium morphology (HP:0012253)	2.10942455
57	Fibular aplasia (HP:0002990)	2.09860857
58	Poor suck (HP:0002033)	2.08554448
59	Abnormality of the lower motor neuron (HP:0002366)	2.08426892
60	Excessive salivation (HP:0003781)	2.06157821
61	Focal seizures (HP:0007359)	2.06102010
62	Anomalous pulmonary venous return (HP:0010772)	2.05627710
63	Abnormal rod and cone electroretinograms (HP:0008323)	1.99172365
64	Pachygyria (HP:0001302)	1.98800188
65	Abnormal ciliary motility (HP:0012262)	1.98189931
66	Broad-based gait (HP:0002136)	1.95906043
67	Type 2 muscle fiber atrophy (HP:0003554)	1.95883241
68	Infertility (HP:0000789)	1.95468414
69	Impaired vibration sensation in the lower limbs (HP:0002166)	1.94594631
70	Renal hypoplasia (HP:0000089)	1.94113291
71	Shawl scrotum (HP:0000049)	1.91718609
72	Abnormality of the renal medulla (HP:0100957)	1.91403958
73	Multicystic kidney dysplasia (HP:0000003)	1.88761952
74	Agitation (HP:0000713)	1.88584868
75	Lipid accumulation in hepatocytes (HP:0006561)	1.88471671
76	Cystic liver disease (HP:0006706)	1.87505347
77	Muscle fiber atrophy (HP:0100295)	1.86396634
78	Delayed CNS myelination (HP:0002188)	1.86322540
79	Renal Fanconi syndrome (HP:0001994)	1.85263199
80	Broad alveolar ridges (HP:0000187)	1.83290227
81	Stage 5 chronic kidney disease (HP:0003774)	1.82978273
82	Megalencephaly (HP:0001355)	1.82597363
83	Chorioretinal atrophy (HP:0000533)	1.81434487
84	Abnormality of midbrain morphology (HP:0002418)	1.81117228
85	Molar tooth sign on MRI (HP:0002419)	1.81117228
86	Hemivertebrae (HP:0002937)	1.80751753
87	Aplasia/Hypoplasia of the earlobes (HP:0009906)	1.78137341
88	Volvulus (HP:0002580)	1.77420539
89	Anophthalmia (HP:0000528)	1.77024391
90	Hypoparathyroidism (HP:0000829)	1.76437599
91	Limb dystonia (HP:0002451)	1.76367422
92	Polyphagia (HP:0002591)	1.76262618
93	Lissencephaly (HP:0001339)	1.73623550
94	Specific learning disability (HP:0001328)	1.72956397
95	Anosmia (HP:0000458)	1.72950881
96	Neoplasm of the adrenal cortex (HP:0100641)	1.72471581
97	Hand muscle atrophy (HP:0009130)	1.70851951
98	Epileptic encephalopathy (HP:0200134)	1.70483422
99	Urinary urgency (HP:0000012)	1.70340692
100	Abnormality of the pulmonary veins (HP:0011718)	1.70117069

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MARK1	4.14871947
2	NTRK3	3.68534214
3	CASK	3.29040006
4	MAP4K2	3.18800083
5	PLK4	3.17916373
6	MINK1	2.81872465
7	PINK1	2.56149255
8	INSRR	2.49509688
9	SIK2	2.42210445
10	DYRK2	2.36492191
11	ADRBK2	1.97497603
12	WNK3	1.80810688
13	DYRK3	1.77702444
14	ICK	1.74851695
15	MAP3K4	1.70326876
16	NTRK2	1.65269646
17	MAP2K7	1.64288963
18	TRIM28	1.63944838
19	SGK494	1.52728789
20	SGK223	1.52728789
21	MAP3K9	1.47013512
22	TYRO3	1.44067703
23	PRKCG	1.43747341
24	MAP3K11	1.40702260
25	TESK1	1.38428770
26	PAK3	1.32966727
27	BRD4	1.30906443
28	RPS6KA2	1.25463278
29	MAPK13	1.22503352
30	DYRK1B	1.20224958
31	ARAF	1.19260449
32	CAMK1G	1.14716889
33	PLK2	1.13788165
34	FRK	1.12536503
35	PNCK	1.09104144
36	PKN1	1.05707358
37	EPHB2	1.05081571
38	BCR	1.04315612
39	BMPR1B	0.98315156
40	CDK5	0.95204421
41	SGK2	0.91918939
42	PRKCZ	0.91073455
43	BRAF	0.90805011
44	CSNK1G2	0.90572864
45	EPHA4	0.85518416
46	CAMKK1	0.84129113
47	DAPK2	0.84100879
48	STK3	0.83986206
49	STK11	0.79248366
50	CAMKK2	0.74730755
51	CSNK1A1	0.74021765
52	CAMK1D	0.73140732
53	CSNK1E	0.72761542
54	MAP2K4	0.72737787
55	PRKG1	0.72215641
56	MAPK15	0.69481123
57	DDR2	0.68527638
58	ERBB2	0.68104143
59	TLK1	0.66708266
60	NEK2	0.65442648
61	SGK1	0.62360428
62	CAMK1	0.62325344
63	PRKCQ	0.61757783
64	PRKACA	0.60986623
65	CAMK4	0.60767937
66	NTRK1	0.59671900
67	CDK3	0.58661029
68	CDK14	0.55901731
69	PHKG1	0.54917404
70	PHKG2	0.54917404
71	PRKCH	0.54623541
72	OXSR1	0.54054693
73	GRK1	0.53277455
74	DYRK1A	0.52947611
75	MAPK8	0.52235118
76	OBSCN	0.52119936
77	CSNK1G3	0.51607431
78	MATK	0.50496557
79	MARK3	0.50441990
80	RPS6KA6	0.49724664
81	CAMK2A	0.49610031
82	RPS6KA1	0.49334595
83	PRKAA1	0.47173729
84	AURKA	0.45576428
85	RPS6KA3	0.45098978
86	CSNK1A1L	0.44748599
87	TXK	0.44736011
88	RPS6KL1	0.44725889
89	RPS6KC1	0.44725889
90	BRSK1	0.43805909
91	PRKCB	0.43489028
92	STK16	0.43446901
93	SGK3	0.42431359
94	NUAK1	0.41138486
95	PIK3CG	0.40840806
96	AKT1	0.40228624
97	LIMK1	0.40160605
98	SIK3	0.39420352
99	MUSK	0.37899378
100	GSK3B	0.37354979

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.85649003
2	Phototransduction_Homo sapiens_hsa04744	2.85590007
3	Nicotine addiction_Homo sapiens_hsa05033	2.74181338
4	Cardiac muscle contraction_Homo sapiens_hsa04260	2.47703110
5	Oxidative phosphorylation_Homo sapiens_hsa00190	2.22575195
6	Parkinsons disease_Homo sapiens_hsa05012	2.11632867
7	Olfactory transduction_Homo sapiens_hsa04740	2.05348872
8	Synaptic vesicle cycle_Homo sapiens_hsa04721	2.00455619
9	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.92895866
10	GABAergic synapse_Homo sapiens_hsa04727	1.88865892
11	Butanoate metabolism_Homo sapiens_hsa00650	1.77953197
12	Morphine addiction_Homo sapiens_hsa05032	1.72436101
13	Steroid biosynthesis_Homo sapiens_hsa00100	1.70593145
14	Axon guidance_Homo sapiens_hsa04360	1.69428397
15	Huntingtons disease_Homo sapiens_hsa05016	1.66016231
16	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.65268424
17	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.61901217
18	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.61430493
19	Cocaine addiction_Homo sapiens_hsa05030	1.60828287
20	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.60293785
21	Dopaminergic synapse_Homo sapiens_hsa04728	1.56143937
22	Phenylalanine metabolism_Homo sapiens_hsa00360	1.54108626
23	Retinol metabolism_Homo sapiens_hsa00830	1.53194968
24	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.52636465
25	Glutamatergic synapse_Homo sapiens_hsa04724	1.51409613
26	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.47483963
27	Taste transduction_Homo sapiens_hsa04742	1.43211099
28	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.42244446
29	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.41361190
30	Alzheimers disease_Homo sapiens_hsa05010	1.34951079
31	Circadian entrainment_Homo sapiens_hsa04713	1.34927319
32	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.33223715
33	Selenocompound metabolism_Homo sapiens_hsa00450	1.30381460
34	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.29963528
35	Serotonergic synapse_Homo sapiens_hsa04726	1.26297931
36	Sulfur relay system_Homo sapiens_hsa04122	1.23219832
37	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.21268369
38	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.21175699
39	Insulin secretion_Homo sapiens_hsa04911	1.18787059
40	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.13892498
41	Fatty acid degradation_Homo sapiens_hsa00071	1.11509909
42	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.04158364
43	Basal transcription factors_Homo sapiens_hsa03022	1.03990036
44	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.03939943
45	Cholinergic synapse_Homo sapiens_hsa04725	1.02132116
46	Amphetamine addiction_Homo sapiens_hsa05031	1.02014237
47	Long-term depression_Homo sapiens_hsa04730	1.00339308
48	Linoleic acid metabolism_Homo sapiens_hsa00591	0.99521403
49	Peroxisome_Homo sapiens_hsa04146	0.99450549
50	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.94571869
51	Arginine biosynthesis_Homo sapiens_hsa00220	0.93762671
52	Chemical carcinogenesis_Homo sapiens_hsa05204	0.93105830
53	Tyrosine metabolism_Homo sapiens_hsa00350	0.88796876
54	Glycerolipid metabolism_Homo sapiens_hsa00561	0.87159452
55	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.86640190
56	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.86086402
57	RNA polymerase_Homo sapiens_hsa03020	0.81716068
58	Gap junction_Homo sapiens_hsa04540	0.80535880
59	cAMP signaling pathway_Homo sapiens_hsa04024	0.77676069
60	Tryptophan metabolism_Homo sapiens_hsa00380	0.76831781
61	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.75221449
62	Regulation of autophagy_Homo sapiens_hsa04140	0.74030776
63	Alcoholism_Homo sapiens_hsa05034	0.73454554
64	Pyruvate metabolism_Homo sapiens_hsa00620	0.73088827
65	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.72057819
66	Caffeine metabolism_Homo sapiens_hsa00232	0.67997793
67	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.67508744
68	Arginine and proline metabolism_Homo sapiens_hsa00330	0.67079058
69	Notch signaling pathway_Homo sapiens_hsa04330	0.66522206
70	Bile secretion_Homo sapiens_hsa04976	0.59798762
71	Basal cell carcinoma_Homo sapiens_hsa05217	0.57116219
72	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.56686633
73	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.56024358
74	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.52126977
75	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.51380706
76	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.51186625
77	PPAR signaling pathway_Homo sapiens_hsa03320	0.51158973
78	Fatty acid metabolism_Homo sapiens_hsa01212	0.50258269
79	Calcium signaling pathway_Homo sapiens_hsa04020	0.49983783
80	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.49175145
81	Hippo signaling pathway_Homo sapiens_hsa04390	0.48269294
82	Ribosome_Homo sapiens_hsa03010	0.48067356
83	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.47304062
84	Metabolic pathways_Homo sapiens_hsa01100	0.47104735
85	Glucagon signaling pathway_Homo sapiens_hsa04922	0.46756355
86	MAPK signaling pathway_Homo sapiens_hsa04010	0.45571930
87	ABC transporters_Homo sapiens_hsa02010	0.43439623
88	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.42002188
89	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.41241292
90	Type II diabetes mellitus_Homo sapiens_hsa04930	0.40492121
91	VEGF signaling pathway_Homo sapiens_hsa04370	0.40186522
92	Renin secretion_Homo sapiens_hsa04924	0.39903173
93	Gastric acid secretion_Homo sapiens_hsa04971	0.39796661
94	Propanoate metabolism_Homo sapiens_hsa00640	0.38915866
95	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.38598982
96	Long-term potentiation_Homo sapiens_hsa04720	0.37100330
97	Melanogenesis_Homo sapiens_hsa04916	0.36938020
98	RNA transport_Homo sapiens_hsa03013	0.36843350
99	Fat digestion and absorption_Homo sapiens_hsa04975	0.36196571
100	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.35849886

TCP10L

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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