ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	pattern specification involved in kidney development (GO:0061004)	5.87985400
2	regulation of T-helper 2 cell differentiation (GO:0045628)	5.70993502
3	regulation of T-helper 1 cell differentiation (GO:0045625)	5.51652912
4	negative regulation of sodium ion transport (GO:0010766)	4.84252842
5	negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)	4.71524204
6	negative regulation of T-helper cell differentiation (GO:0045623)	4.71524204
7	positive regulation of T cell cytokine production (GO:0002726)	4.66617623
8	indole-containing compound catabolic process (GO:0042436)	4.65702414
9	indolalkylamine catabolic process (GO:0046218)	4.65702414
10	tryptophan catabolic process (GO:0006569)	4.65702414
11	fusion of sperm to egg plasma membrane (GO:0007342)	4.52328120
12	kynurenine metabolic process (GO:0070189)	4.45727825
13	negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)	4.28444915
14	sperm motility (GO:0030317)	4.22741139
15	cellular response to exogenous dsRNA (GO:0071360)	4.07661917
16	phosphate ion homeostasis (GO:0055062)	4.02294004
17	trivalent inorganic anion homeostasis (GO:0072506)	4.02294004
18	oligosaccharide catabolic process (GO:0009313)	3.91728702
19	response to pheromone (GO:0019236)	3.91014942
20	regulation of memory T cell differentiation (GO:0043380)	3.88443979
21	positive regulation of type 2 immune response (GO:0002830)	3.84572969
22	cilium or flagellum-dependent cell motility (GO:0001539)	3.76582494
23	cellular anion homeostasis (GO:0030002)	3.76547731
24	negative regulation of alpha-beta T cell differentiation (GO:0046639)	3.75628270
25	intestinal cholesterol absorption (GO:0030299)	3.70814519
26	regulation of regulatory T cell differentiation (GO:0045589)	3.68572350
27	natural killer cell activation involved in immune response (GO:0002323)	3.67976075
28	positive regulation of T-helper cell differentiation (GO:0045624)	3.63479288
29	aromatic amino acid family catabolic process (GO:0009074)	3.57891213
30	sulfation (GO:0051923)	3.50558038
31	positive regulation of fatty acid beta-oxidation (GO:0032000)	3.50496206
32	tryptophan metabolic process (GO:0006568)	3.49807392
33	negative regulation of fibrinolysis (GO:0051918)	3.37433312
34	plasma membrane fusion (GO:0045026)	3.37432671
35	low-density lipoprotein particle remodeling (GO:0034374)	3.34662496
36	regulation of T cell cytokine production (GO:0002724)	3.32820451
37	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.31669561
38	negative regulation of alpha-beta T cell activation (GO:0046636)	3.31000120
39	axonemal dynein complex assembly (GO:0070286)	3.30467458
40	peroxisome fission (GO:0016559)	3.27154884
41	membrane protein intracellular domain proteolysis (GO:0031293)	3.24825170
42	protein-lipid complex remodeling (GO:0034368)	3.14564664
43	macromolecular complex remodeling (GO:0034367)	3.14564664
44	plasma lipoprotein particle remodeling (GO:0034369)	3.14564664
45	spermatid development (GO:0007286)	3.13670468
46	regulation of somitogenesis (GO:0014807)	3.12035421
47	acrosome assembly (GO:0001675)	3.10898805
48	cellular response to prostaglandin stimulus (GO:0071379)	3.07672116
49	regulation of T-helper 1 type immune response (GO:0002825)	3.06076906
50	glomerular basement membrane development (GO:0032836)	3.00580926
51	regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	2.98172778
52	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	2.95118247
53	regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)	2.94740756
54	positive regulation of endothelial cell differentiation (GO:0045603)	2.91424443
55	negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)	2.89851068
56	regulation of interleukin-13 production (GO:0032656)	2.89285881
57	cell proliferation involved in metanephros development (GO:0072203)	2.87231199
58	high-density lipoprotein particle remodeling (GO:0034375)	2.86571317
59	adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)	2.86258019
60	gamma-aminobutyric acid transport (GO:0015812)	2.85627401
61	cellular zinc ion homeostasis (GO:0006882)	2.85270602
62	indole-containing compound metabolic process (GO:0042430)	2.84317121
63	regulation of fibrinolysis (GO:0051917)	2.83707212
64	regulation of cytokine secretion involved in immune response (GO:0002739)	2.83593149
65	positive regulation of lipid catabolic process (GO:0050996)	2.81569196
66	primary amino compound metabolic process (GO:1901160)	2.80066690
67	regulation of cilium movement (GO:0003352)	2.78367918
68	blood coagulation, intrinsic pathway (GO:0007597)	2.78290673
69	indolalkylamine metabolic process (GO:0006586)	2.77314756
70	regulation of T-helper cell differentiation (GO:0045622)	2.76985018
71	nephron epithelium morphogenesis (GO:0072088)	2.76852827
72	nephron tubule morphogenesis (GO:0072078)	2.76852827
73	acrosome reaction (GO:0007340)	2.75511116
74	negative regulation of telomere maintenance (GO:0032205)	2.74878750
75	reverse cholesterol transport (GO:0043691)	2.71974919
76	peristalsis (GO:0030432)	2.71792283
77	response to prostaglandin (GO:0034694)	2.71516844
78	negative regulation of astrocyte differentiation (GO:0048712)	2.70296150
79	negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)	2.69645473
80	neuronal action potential (GO:0019228)	2.68633218
81	sperm capacitation (GO:0048240)	2.68007505
82	modified amino acid transport (GO:0072337)	2.67142982
83	amine catabolic process (GO:0009310)	2.64812725
84	cellular biogenic amine catabolic process (GO:0042402)	2.64812725
85	2-oxoglutarate metabolic process (GO:0006103)	2.64594114
86	basic amino acid transport (GO:0015802)	2.63822078
87	very-low-density lipoprotein particle assembly (GO:0034379)	2.62745351
88	peptidyl-threonine dephosphorylation (GO:0035970)	2.62714154
89	cholesterol efflux (GO:0033344)	2.62092694
90	negative regulation of sterol transport (GO:0032372)	2.62026636
91	negative regulation of cholesterol transport (GO:0032375)	2.62026636
92	sperm-egg recognition (GO:0035036)	2.61760667
93	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	2.61734783
94	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	2.61734783
95	serotonin metabolic process (GO:0042428)	2.61462077
96	negative regulation of T cell differentiation (GO:0045581)	2.59205529
97	sleep (GO:0030431)	2.57636659
98	positive regulation of T cell mediated immunity (GO:0002711)	2.57273121
99	negative regulation of insulin receptor signaling pathway (GO:0046627)	2.56552062
100	multicellular organism reproduction (GO:0032504)	2.56379942

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.75212057
2	EZH2_22144423_ChIP-Seq_EOC_Human	2.87012245
3	VDR_22108803_ChIP-Seq_LS180_Human	2.69712458
4	GBX2_23144817_ChIP-Seq_PC3_Human	2.55505467
5	ZNF274_21170338_ChIP-Seq_K562_Hela	2.39606695
6	TCF4_18268006_ChIP-ChIP_LS174T_Human	2.27013263
7	AR_21572438_ChIP-Seq_LNCaP_Human	2.20377856
8	EGR1_23403033_ChIP-Seq_LIVER_Mouse	2.14261397
9	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.03215382
10	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.92559075
11	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.92559075
12	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.76359851
13	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.73943741
14	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.73219640
15	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.64632278
16	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.64032323
17	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.62278615
18	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.62158118
19	ER_23166858_ChIP-Seq_MCF-7_Human	1.57319131
20	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.56147750
21	FOXA2_19822575_ChIP-Seq_HepG2_Human	1.53497500
22	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	1.52965314
23	FUS_26573619_Chip-Seq_HEK293_Human	1.52385884
24	TAF15_26573619_Chip-Seq_HEK293_Human	1.47525594
25	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.46049843
26	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.42552256
27	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.42481005
28	CBP_20019798_ChIP-Seq_JUKART_Human	1.42481005
29	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.39150991
30	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.36455086
31	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.35262133
32	RUNX2_22187159_ChIP-Seq_PCA_Human	1.33887554
33	P300_19829295_ChIP-Seq_ESCs_Human	1.33502228
34	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.33490964
35	DROSHA_22980978_ChIP-Seq_HELA_Human	1.33135314
36	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.32596111
37	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.30061463
38	REST_21632747_ChIP-Seq_MESCs_Mouse	1.28003144
39	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.25932268
40	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.25635609
41	RNF2_27304074_Chip-Seq_NSC_Mouse	1.24387579
42	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.24237061
43	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.21657389
44	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.21019562
45	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.20675660
46	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.19880154
47	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.19783123
48	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.19559684
49	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.17956861
50	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.17230252
51	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.16995082
52	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.16969158
53	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.16729384
54	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.16723457
55	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.16234234
56	AR_25329375_ChIP-Seq_VCAP_Human	1.16074192
57	RXR_22108803_ChIP-Seq_LS180_Human	1.15848713
58	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.13390125
59	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.13241241
60	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.13059513
61	TAF2_19829295_ChIP-Seq_ESCs_Human	1.12256032
62	LXR_22158963_ChIP-Seq_LIVER_Mouse	1.10837003
63	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.10393997
64	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.10393997
65	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.09851775
66	RAC3_21632823_ChIP-Seq_H3396_Human	1.08424437
67	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.06780646
68	NANOG_20526341_ChIP-Seq_ESCs_Human	1.06055081
69	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.05518020
70	AR_20517297_ChIP-Seq_VCAP_Human	1.05486518
71	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.04408750
72	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.04386908
73	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.04386908
74	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.03525875
75	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.03130991
76	STAT3_23295773_ChIP-Seq_U87_Human	1.02739195
77	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.01166086
78	CEBPB_22108803_ChIP-Seq_LS180_Human	1.00876371
79	SMAD4_21799915_ChIP-Seq_A2780_Human	1.00376391
80	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.00088686
81	ERA_21632823_ChIP-Seq_H3396_Human	0.98393248
82	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.97606775
83	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.97219884
84	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	0.96866401
85	WDR5_24793694_ChIP-Seq_LNCAP_Human	0.96704567
86	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.96554443
87	SOX2_19829295_ChIP-Seq_ESCs_Human	0.95882719
88	NANOG_19829295_ChIP-Seq_ESCs_Human	0.95882719
89	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.95598479
90	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.95586763
91	TP53_18474530_ChIP-ChIP_U2OS_Human	0.95140975
92	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	0.95106511
93	MYC_19829295_ChIP-Seq_ESCs_Human	0.94282398
94	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.94246003
95	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	0.93867848
96	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	0.93741869
97	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.93446454
98	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	0.93014010
99	RUNX_20019798_ChIP-Seq_JUKART_Human	0.92953571
100	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.92405743

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005410_abnormal_fertilization	4.40429623
2	MP0002736_abnormal_nociception_after	3.35683331
3	MP0000569_abnormal_digit_pigmentation	3.35107039
4	MP0002139_abnormal_hepatobiliary_system	3.13952492
5	MP0003195_calcinosis	3.11242503
6	MP0002254_reproductive_system_inflammat	3.02392938
7	MP0005377_hearing/vestibular/ear_phenot	3.01799275
8	MP0003878_abnormal_ear_physiology	3.01799275
9	MP0005645_abnormal_hypothalamus_physiol	3.01296663
10	MP0001968_abnormal_touch/_nociception	2.97663339
11	MP0008875_abnormal_xenobiotic_pharmacok	2.61853219
12	MP0000566_synostosis	2.54677365
13	MP0005085_abnormal_gallbladder_physiolo	2.51395738
14	MP0003136_yellow_coat_color	2.47243097
15	MP0005365_abnormal_bile_salt	2.42539149
16	MP0010329_abnormal_lipoprotein_level	2.26953461
17	MP0005360_urolithiasis	2.20723219
18	MP0002735_abnormal_chemical_nociception	2.17081485
19	MP0004043_abnormal_pH_regulation	2.10611546
20	MP0004885_abnormal_endolymph	2.08694585
21	MP0001666_abnormal_nutrient_absorption	1.94078015
22	MP0005167_abnormal_blood-brain_barrier	1.90422735
23	MP0004742_abnormal_vestibular_system	1.89165450
24	MP0005423_abnormal_somatic_nervous	1.87686461
25	MP0002653_abnormal_ependyma_morphology	1.81152528
26	MP0001346_abnormal_lacrimal_gland	1.77418354
27	MP0003252_abnormal_bile_duct	1.74406383
28	MP0003646_muscle_fatigue	1.70023253
29	MP0003698_abnormal_male_reproductive	1.69941527
30	MP0003879_abnormal_hair_cell	1.63547664
31	MP0005671_abnormal_response_to	1.62356520
32	MP0002822_catalepsy	1.57129492
33	MP0001905_abnormal_dopamine_level	1.44535492
34	MP0005670_abnormal_white_adipose	1.43815167
35	MP0005332_abnormal_amino_acid	1.42594105
36	MP0001348_abnormal_lacrimal_gland	1.42125849
37	MP0003941_abnormal_skin_development	1.39305161
38	MP0001485_abnormal_pinna_reflex	1.39056558
39	MP0003638_abnormal_response/metabolism_	1.37172397
40	MP0003868_abnormal_feces_composition	1.37000448
41	MP0001929_abnormal_gametogenesis	1.32223083
42	MP0005187_abnormal_penis_morphology	1.31389791
43	MP0008872_abnormal_physiological_respon	1.27388743
44	MP0003122_maternal_imprinting	1.22006776
45	MP0002733_abnormal_thermal_nociception	1.21363445
46	MP0005058_abnormal_lysosome_morphology	1.20510720
47	MP0003315_abnormal_perineum_morphology	1.19284565
48	MP0002067_abnormal_sensory_capabilities	1.18124181
49	MP0009745_abnormal_behavioral_response	1.17744667
50	MP0000534_abnormal_ureter_morphology	1.17170306
51	MP0001765_abnormal_ion_homeostasis	1.14151328
52	MP0002118_abnormal_lipid_homeostasis	1.13907433
53	MP0001501_abnormal_sleep_pattern	1.10074472
54	MP0002160_abnormal_reproductive_system	1.08895936
55	MP0001873_stomach_inflammation	1.04605313
56	MP0009785_altered_susceptibility_to	1.04433808
57	MP0002138_abnormal_hepatobiliary_system	1.04143885
58	MP0009046_muscle_twitch	1.03578908
59	MP0003329_amyloid_beta_deposits	1.02691693
60	MP0002161_abnormal_fertility/fecundity	1.02548369
61	MP0001486_abnormal_startle_reflex	0.99462134
62	MP0002272_abnormal_nervous_system	0.97686540
63	MP0003303_peritoneal_inflammation	0.97366632
64	MP0005083_abnormal_biliary_tract	0.92779986
65	MP0004142_abnormal_muscle_tone	0.91313255
66	MP0006292_abnormal_olfactory_placode	0.91291609
67	MP0005448_abnormal_energy_balance	0.91283065
68	MP0002638_abnormal_pupillary_reflex	0.88386924
69	MP0009384_cardiac_valve_regurgitation	0.87783645
70	MP0002557_abnormal_social/conspecific_i	0.86652973
71	MP0005310_abnormal_salivary_gland	0.83416037
72	MP0000639_abnormal_adrenal_gland	0.82905532
73	MP0000427_abnormal_hair_cycle	0.82460085
74	MP0002938_white_spotting	0.79755529
75	MP0003633_abnormal_nervous_system	0.79421362
76	MP0002229_neurodegeneration	0.78597712
77	MP0002572_abnormal_emotion/affect_behav	0.77994083
78	MP0002064_seizures	0.77250015
79	MP0005551_abnormal_eye_electrophysiolog	0.75978816
80	MP0000026_abnormal_inner_ear	0.75889933
81	MP0005636_abnormal_mineral_homeostasis	0.75741782
82	MP0001970_abnormal_pain_threshold	0.74476405
83	MP0000631_abnormal_neuroendocrine_gland	0.73615389
84	MP0008569_lethality_at_weaning	0.73230748
85	MP0001963_abnormal_hearing_physiology	0.70893935
86	MP0009643_abnormal_urine_homeostasis	0.70567517
87	MP0009840_abnormal_foam_cell	0.69835147
88	MP0009278_abnormal_bone_marrow	0.69613301
89	MP0000604_amyloidosis	0.68985185
90	MP0000230_abnormal_systemic_arterial	0.68815240
91	MP0005379_endocrine/exocrine_gland_phen	0.68723142
92	MP0005389_reproductive_system_phenotype	0.68036409
93	MP0003631_nervous_system_phenotype	0.67695578
94	MP0008995_early_reproductive_senescence	0.66125773
95	MP0001664_abnormal_digestion	0.65676901
96	MP0002148_abnormal_hypersensitivity_rea	0.65114505
97	MP0002876_abnormal_thyroid_physiology	0.64453996
98	MP0000609_abnormal_liver_physiology	0.61958271
99	MP0002210_abnormal_sex_determination	0.60873183
100	MP0005084_abnormal_gallbladder_morpholo	0.59387560

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Deep venous thrombosis (HP:0002625)	4.30718302
2	Enlarged epiphyses (HP:0010580)	4.01741985
3	Facial shape deformation (HP:0011334)	3.91789625
4	Potter facies (HP:0002009)	3.91789625
5	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.89574520
6	Absent/shortened dynein arms (HP:0200106)	3.89574520
7	Prolonged partial thromboplastin time (HP:0003645)	3.81729696
8	Glomerulonephritis (HP:0000099)	3.72691085
9	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	3.45370545
10	Nephritis (HP:0000123)	3.36430748
11	Conical tooth (HP:0000698)	3.11794705
12	Osteomalacia (HP:0002749)	3.08518437
13	Epidermoid cyst (HP:0200040)	3.04561789
14	Xanthomatosis (HP:0000991)	2.93574631
15	Hyperphosphaturia (HP:0003109)	2.91416911
16	Hypobetalipoproteinemia (HP:0003563)	2.85114923
17	Abnormal respiratory epithelium morphology (HP:0012253)	2.71945898
18	Abnormal respiratory motile cilium morphology (HP:0005938)	2.71945898
19	Progressive cerebellar ataxia (HP:0002073)	2.67006460
20	Spastic tetraparesis (HP:0001285)	2.57213663
21	Supernumerary bones of the axial skeleton (HP:0009144)	2.46337912
22	Abnormal urine phosphate concentration (HP:0012599)	2.45272448
23	Vascular calcification (HP:0004934)	2.44237238
24	Hypophosphatemic rickets (HP:0004912)	2.42070181
25	Midline defect of the nose (HP:0004122)	2.41488779
26	Tubulointerstitial abnormality (HP:0001969)	2.38574637
27	Tubulointerstitial fibrosis (HP:0005576)	2.34912592
28	Complement deficiency (HP:0004431)	2.33901081
29	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	2.33313787
30	Supernumerary spleens (HP:0009799)	2.31731052
31	Joint hemorrhage (HP:0005261)	2.31408985
32	Spontaneous abortion (HP:0005268)	2.27485143
33	Attenuation of retinal blood vessels (HP:0007843)	2.26797297
34	Metabolic alkalosis (HP:0200114)	2.24006235
35	Abnormal urine output (HP:0012590)	2.22231789
36	Hypoplastic ischia (HP:0003175)	2.21301469
37	Delayed CNS myelination (HP:0002188)	2.20961500
38	Stage 5 chronic kidney disease (HP:0003774)	2.18981191
39	Abnormality of the pubic bones (HP:0003172)	2.18276052
40	Tongue fasciculations (HP:0001308)	2.17374860
41	Abnormal ciliary motility (HP:0012262)	2.17221528
42	Trigonocephaly (HP:0000243)	2.16699303
43	Agitation (HP:0000713)	2.14653504
44	Tubular atrophy (HP:0000092)	2.14082785
45	Pancreatic cysts (HP:0001737)	2.13547105
46	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	2.12414251
47	Progressive hearing impairment (HP:0001730)	2.09819217
48	Gingival bleeding (HP:0000225)	2.06430045
49	Neoplasm of the heart (HP:0100544)	2.06339310
50	Muscle fibrillation (HP:0010546)	1.99737246
51	Hyperalaninemia (HP:0003348)	1.99364650
52	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.99364650
53	Abnormality of alanine metabolism (HP:0010916)	1.99364650
54	Cardiovascular calcification (HP:0011915)	1.98580860
55	Hypokalemic alkalosis (HP:0001949)	1.97507413
56	Back pain (HP:0003418)	1.96586099
57	Tubulointerstitial nephritis (HP:0001970)	1.96270711
58	Retrobulbar optic neuritis (HP:0100654)	1.95758654
59	Optic neuritis (HP:0100653)	1.95758654
60	Hypercholesterolemia (HP:0003124)	1.93993426
61	Anomalous pulmonary venous return (HP:0010772)	1.92579522
62	Genetic anticipation (HP:0003743)	1.92340564
63	Abnormality of aromatic amino acid family metabolism (HP:0004338)	1.89548027
64	Keratoconjunctivitis (HP:0001096)	1.87441465
65	Tinnitus (HP:0000360)	1.86710418
66	Proximal tubulopathy (HP:0000114)	1.85661678
67	Nephronophthisis (HP:0000090)	1.85520635
68	Focal segmental glomerulosclerosis (HP:0000097)	1.85262219
69	Abnormality of renal excretion (HP:0011036)	1.84203365
70	Supernumerary ribs (HP:0005815)	1.81269300
71	Increased IgE level (HP:0003212)	1.79044309
72	True hermaphroditism (HP:0010459)	1.78628579
73	Arthropathy (HP:0003040)	1.76984613
74	Abnormality of the ischium (HP:0003174)	1.76773247
75	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.76529965
76	Broad palm (HP:0001169)	1.76454635
77	Abnormality of macular pigmentation (HP:0008002)	1.76156113
78	Amyloidosis (HP:0011034)	1.75024816
79	Abnormality of the renal cortex (HP:0011035)	1.74666609
80	Renovascular hypertension (HP:0100817)	1.74250045
81	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.74083787
82	Abnormality of urine glucose concentration (HP:0011016)	1.74029780
83	Glycosuria (HP:0003076)	1.74029780
84	Widely patent fontanelles and sutures (HP:0004492)	1.73991775
85	Abnormality of cochlea (HP:0000375)	1.72859196
86	Abnormality of the renal medulla (HP:0100957)	1.72603828
87	Acanthocytosis (HP:0001927)	1.71829725
88	Prominent supraorbital ridges (HP:0000336)	1.71754058
89	Increased neuronal autofluorescent lipopigment (HP:0002074)	1.71340252
90	Glomerulosclerosis (HP:0000096)	1.71233415
91	Opisthotonus (HP:0002179)	1.71187931
92	Hemiplegia (HP:0002301)	1.70764384
93	Abnormal respiratory motile cilium physiology (HP:0012261)	1.69990152
94	Hydroxyprolinuria (HP:0003080)	1.67575267
95	Abnormality of proline metabolism (HP:0010907)	1.67575267
96	Hyperlipoproteinemia (HP:0010980)	1.67357823
97	Congenital stationary night blindness (HP:0007642)	1.65426732
98	Morphological abnormality of the pyramidal tract (HP:0002062)	1.63666720
99	Abnormality of the sella turcica (HP:0002679)	1.63047859
100	Restlessness (HP:0000711)	1.62756358

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	2.77571094
2	RIPK4	2.42973798
3	PNCK	2.17082298
4	TLK1	2.14955531
5	MAP4K2	13.6793015
6	MAPK15	1.92439329
7	TXK	1.65578893
8	ACVR1B	1.62062935
9	GRK6	1.53699382
10	BCKDK	1.47003946
11	TYRO3	1.40400554
12	WNK4	1.29626767
13	BMPR1B	1.27901538
14	OXSR1	1.27424689
15	DDR2	1.23313454
16	ICK	1.21314709
17	CAMK1D	1.12166569
18	MAP3K11	1.04783632
19	STK39	1.03547378
20	ADRBK2	1.03295253
21	CAMK1G	1.00288859
22	PLK4	0.99409371
23	CDK3	0.92715476
24	IRAK1	0.92119188
25	CAMKK2	0.90708504
26	FGFR3	0.89601731
27	EPHA3	0.88124128
28	TAOK3	0.87656251
29	MAP3K4	0.85495980
30	ZAK	0.81010709
31	YES1	0.78640520
32	PDK1	0.73168559
33	MAPK13	0.72025762
34	FGFR4	0.71264511
35	CDK19	0.68858443
36	INSRR	0.65580009
37	TBK1	0.65545252
38	MATK	0.62316200
39	CDK8	0.60286581
40	PRKCG	0.59093420
41	PRKCQ	0.58236897
42	STK38L	0.57712841
43	CSNK1A1L	0.57260268
44	KIT	0.56613201
45	CSNK1G2	0.56557097
46	PDPK1	0.56299888
47	CSK	0.55835367
48	TAOK2	0.55307911
49	PRKCZ	0.51556026
50	CSNK1G3	0.50608310
51	GRK7	0.50253075
52	STK38	0.49443130
53	CAMK1	0.47069525
54	PDGFRB	0.46506617
55	CSNK1G1	0.46333501
56	IKBKB	0.44661807
57	TAOK1	0.41804741
58	MAP3K3	0.40904653
59	ITK	0.39974248
60	DYRK1B	0.36911291
61	MAP3K14	0.36601103
62	SYK	0.36497887
63	CAMK4	0.36406448
64	PKN1	0.35327556
65	FGFR1	0.34201495
66	MAP3K7	0.33867950
67	IKBKE	0.31734701
68	IRAK2	0.29593621
69	PIM2	0.29377764
70	CHUK	0.29030520
71	LYN	0.28828789
72	CDK7	0.28778500
73	UHMK1	0.24320933
74	NTRK2	0.22857342
75	GRK1	0.20629799
76	IGF1R	0.19723043
77	AKT3	0.19142799
78	CDK12	0.18889679
79	WEE1	0.18845431
80	JAK3	0.18552958
81	TEC	0.18451505
82	CAMK2A	0.18340361
83	SGK1	0.18267968
84	PLK2	0.17622494
85	ERBB2	0.17599423
86	PRKACB	0.17334421
87	INSR	0.17243272
88	PRKACA	0.17194606
89	IRAK4	0.16973321
90	MAP4K1	0.16853754
91	MAPK11	0.16643714
92	LCK	0.16589821
93	RPS6KA3	0.15699257
94	TGFBR2	0.15029769
95	CSNK1D	0.14617692
96	CAMK2B	0.14313300
97	PRKG1	0.14292224
98	RET	0.13449892
99	ADRBK1	0.13120403
100	PIK3CA	0.13009436

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Fatty acid biosynthesis_Homo sapiens_hsa00061	2.77808802
2	Complement and coagulation cascades_Homo sapiens_hsa04610	2.63451640
3	Cyanoamino acid metabolism_Homo sapiens_hsa00460	2.61599515
4	Caffeine metabolism_Homo sapiens_hsa00232	2.44780911
5	ABC transporters_Homo sapiens_hsa02010	2.43029873
6	Butanoate metabolism_Homo sapiens_hsa00650	2.24722769
7	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.22854532
8	Fat digestion and absorption_Homo sapiens_hsa04975	2.08526829
9	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.03244470
10	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.99997065
11	Nitrogen metabolism_Homo sapiens_hsa00910	1.96204801
12	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.91163675
13	Linoleic acid metabolism_Homo sapiens_hsa00591	1.89634347
14	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.82856950
15	Sulfur relay system_Homo sapiens_hsa04122	1.79651742
16	Glycerolipid metabolism_Homo sapiens_hsa00561	1.74089863
17	Tryptophan metabolism_Homo sapiens_hsa00380	1.72875330
18	Steroid biosynthesis_Homo sapiens_hsa00100	1.72357655
19	Sulfur metabolism_Homo sapiens_hsa00920	1.66123233
20	Renin-angiotensin system_Homo sapiens_hsa04614	1.65240802
21	Retinol metabolism_Homo sapiens_hsa00830	1.62078691
22	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.61373327
23	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.56975382
24	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.45673293
25	PPAR signaling pathway_Homo sapiens_hsa03320	1.43679544
26	Peroxisome_Homo sapiens_hsa04146	1.43290753
27	Nicotine addiction_Homo sapiens_hsa05033	1.43220333
28	Chemical carcinogenesis_Homo sapiens_hsa05204	1.40990194
29	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.38552599
30	Taste transduction_Homo sapiens_hsa04742	1.29214537
31	Bile secretion_Homo sapiens_hsa04976	1.28296192
32	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.26621256
33	Histidine metabolism_Homo sapiens_hsa00340	1.25223541
34	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.23977284
35	Salivary secretion_Homo sapiens_hsa04970	1.23123050
36	Olfactory transduction_Homo sapiens_hsa04740	1.22135029
37	Graft-versus-host disease_Homo sapiens_hsa05332	1.21561124
38	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.21368613
39	Allograft rejection_Homo sapiens_hsa05330	1.19644332
40	Fatty acid degradation_Homo sapiens_hsa00071	1.15867954
41	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.14121054
42	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.13179997
43	Phototransduction_Homo sapiens_hsa04744	1.08183916
44	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	1.07204737
45	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.06925540
46	African trypanosomiasis_Homo sapiens_hsa05143	1.06044157
47	Fatty acid metabolism_Homo sapiens_hsa01212	1.04189768
48	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.03562308
49	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.01692868
50	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.98329705
51	Malaria_Homo sapiens_hsa05144	0.95971703
52	Ether lipid metabolism_Homo sapiens_hsa00565	0.92049556
53	Cardiac muscle contraction_Homo sapiens_hsa04260	0.91133821
54	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.87195728
55	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.86058151
56	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.85616315
57	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.83895829
58	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.80821773
59	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.80696337
60	Type I diabetes mellitus_Homo sapiens_hsa04940	0.79209797
61	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.79200176
62	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.79163424
63	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.79048417
64	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.77219971
65	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.73775077
66	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.71845845
67	Protein digestion and absorption_Homo sapiens_hsa04974	0.70949586
68	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.69143534
69	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.67631320
70	Glutamatergic synapse_Homo sapiens_hsa04724	0.67366969
71	Phenylalanine metabolism_Homo sapiens_hsa00360	0.66695764
72	Type II diabetes mellitus_Homo sapiens_hsa04930	0.65052191
73	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.64658478
74	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.61934950
75	Asthma_Homo sapiens_hsa05310	0.60447197
76	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.55680776
77	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.55459588
78	Morphine addiction_Homo sapiens_hsa05032	0.54616567
79	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.53832588
80	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.53327491
81	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.51298100
82	Renin secretion_Homo sapiens_hsa04924	0.51287874
83	Propanoate metabolism_Homo sapiens_hsa00640	0.50138876
84	Insulin resistance_Homo sapiens_hsa04931	0.49763400
85	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.47027249
86	GABAergic synapse_Homo sapiens_hsa04727	0.46439617
87	Primary immunodeficiency_Homo sapiens_hsa05340	0.43094515
88	cAMP signaling pathway_Homo sapiens_hsa04024	0.42850331
89	Other glycan degradation_Homo sapiens_hsa00511	0.41105490
90	beta-Alanine metabolism_Homo sapiens_hsa00410	0.40602226
91	Tyrosine metabolism_Homo sapiens_hsa00350	0.39175789
92	Arginine and proline metabolism_Homo sapiens_hsa00330	0.38487341
93	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.36603842
94	Arginine biosynthesis_Homo sapiens_hsa00220	0.35198810
95	TNF signaling pathway_Homo sapiens_hsa04668	0.33005890
96	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.32752492
97	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.32142929
98	Antigen processing and presentation_Homo sapiens_hsa04612	0.30886268
99	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.30403692
100	Circadian entrainment_Homo sapiens_hsa04713	0.30108026

TCP10L2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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