TCP11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1spermatid development (GO:0007286)9.97286791
2axonemal dynein complex assembly (GO:0070286)9.94229816
3epithelial cilium movement (GO:0003351)9.93777956
4plasma membrane fusion (GO:0045026)9.75394650
5cilium or flagellum-dependent cell motility (GO:0001539)9.60902132
6motile cilium assembly (GO:0044458)9.51335551
7regulation of cilium movement (GO:0003352)9.07687363
8reproduction (GO:0000003)8.86437358
9cilium movement (GO:0003341)8.14708506
10negative regulation of inclusion body assembly (GO:0090084)7.67505843
11protein targeting to Golgi (GO:0000042)7.66728134
12epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.48522702
13piRNA metabolic process (GO:0034587)7.43869476
14sperm capacitation (GO:0048240)7.42046067
15synaptonemal complex organization (GO:0070193)7.35401310
16establishment of protein localization to Golgi (GO:0072600)7.34945876
17rRNA methylation (GO:0031167)7.23293323
18retrograde transport, vesicle recycling within Golgi (GO:0000301)7.16155305
19single fertilization (GO:0007338)7.15150951
20male meiosis (GO:0007140)7.14985841
21synaptonemal complex assembly (GO:0007130)7.14136829
22phosphatidylethanolamine biosynthetic process (GO:0006646)6.96377754
23organic cation transport (GO:0015695)6.80136197
24* spermatogenesis (GO:0007283)6.74959252
25* male gamete generation (GO:0048232)6.72487486
26response to pheromone (GO:0019236)6.66454690
27microtubule depolymerization (GO:0007019)6.48197542
28phosphatidylethanolamine metabolic process (GO:0046337)6.42787670
29regulation of inclusion body assembly (GO:0090083)6.32060854
30fertilization (GO:0009566)6.20232845
31centriole replication (GO:0007099)6.19268436
32* gamete generation (GO:0007276)6.17525884
33rRNA modification (GO:0000154)6.07474819
34calcium ion-dependent exocytosis (GO:0017156)5.58081132
35germ cell development (GO:0007281)5.56753577
36centriole assembly (GO:0098534)5.52306436
37protein localization to Golgi apparatus (GO:0034067)5.51033962
38cellular process involved in reproduction in multicellular organism (GO:0022412)5.44634707
39chromosome condensation (GO:0030261)5.42933628
40regulation of microtubule-based movement (GO:0060632)5.40167855
41ventricular system development (GO:0021591)5.29053543
42DNA packaging (GO:0006323)5.20442330
43male meiosis I (GO:0007141)5.15798663
44regulation of centriole replication (GO:0046599)5.10378736
45cell recognition (GO:0008037)4.91622834
46microtubule severing (GO:0051013)4.87850474
47* multicellular organismal reproductive process (GO:0048609)4.86930662
48glycerol ether metabolic process (GO:0006662)4.85441850
49seminiferous tubule development (GO:0072520)4.82296295
50chromosome organization involved in meiosis (GO:0070192)4.80570755
51positive regulation of Rab GTPase activity (GO:0032851)4.77632975
52regulation of Rab GTPase activity (GO:0032313)4.77632975
53DNA methylation involved in gamete generation (GO:0043046)4.71624205
54cellular ketone body metabolic process (GO:0046950)4.69665860
55left/right pattern formation (GO:0060972)4.66216105
56spermatid nucleus differentiation (GO:0007289)4.61578287
57ether metabolic process (GO:0018904)4.48369240
58regulation of transcription involved in cell fate commitment (GO:0060850)4.38925416
59meiotic nuclear division (GO:0007126)4.31707703
60chaperone-mediated protein complex assembly (GO:0051131)4.22860501
61meiosis I (GO:0007127)4.13634623
62ketone body metabolic process (GO:1902224)4.13445324
63multicellular organismal movement (GO:0050879)4.02433539
64musculoskeletal movement (GO:0050881)4.02433539
65sexual reproduction (GO:0019953)3.97818048
66* multicellular organismal development (GO:0007275)3.89475489
67microtubule nucleation (GO:0007020)3.88331747
68single strand break repair (GO:0000012)3.84916463
69protein polyglutamylation (GO:0018095)3.71571194
70genitalia morphogenesis (GO:0035112)3.67806842
71response to acidic pH (GO:0010447)3.57264074
72meiotic cell cycle (GO:0051321)3.56955019
73protein refolding (GO:0042026)3.53710474
74membrane protein intracellular domain proteolysis (GO:0031293)3.52038632
75glomerular visceral epithelial cell development (GO:0072015)3.49770666
76protein localization to cilium (GO:0061512)3.44982836
77regulation of spindle checkpoint (GO:0090231)3.44583446
78nuclear pore complex assembly (GO:0051292)3.41415623
79histone H3-K9 demethylation (GO:0033169)3.40699993
80cellular response to pH (GO:0071467)3.39473894
81glomerular epithelial cell development (GO:0072310)3.37363948
82sequestering of actin monomers (GO:0042989)3.35952647
83nucleosome disassembly (GO:0006337)3.35526348
84protein-DNA complex disassembly (GO:0032986)3.35526348
85cerebral cortex neuron differentiation (GO:0021895)3.30483183
86microtubule polymerization or depolymerization (GO:0031109)3.28415885
87homeostasis of number of cells within a tissue (GO:0048873)3.27875466
88peptidyl-threonine dephosphorylation (GO:0035970)3.20360942
89amino-acid betaine transport (GO:0015838)3.19573781
90carnitine transport (GO:0015879)3.19573781
91glycolytic process (GO:0006096)3.19451771
92regulation of interleukin-13 production (GO:0032656)3.16676448
93nucleus organization (GO:0006997)3.15010454
94protein K11-linked deubiquitination (GO:0035871)3.14904744
95monoubiquitinated protein deubiquitination (GO:0035520)3.14845213
96mitotic sister chromatid cohesion (GO:0007064)3.14577044
97negative regulation of Rho protein signal transduction (GO:0035024)3.11614536
98RNA localization (GO:0006403)3.08992496
99Golgi to endosome transport (GO:0006895)3.06883824
100protein depolymerization (GO:0051261)3.05613454
101carnitine transmembrane transport (GO:1902603)3.01476586
102mitochondrial fission (GO:0000266)3.00395730
103RNA destabilization (GO:0050779)2.98533055
104interferon-gamma secretion (GO:0072643)2.98336113
105nucleoside diphosphate phosphorylation (GO:0006165)2.97555152
106cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.96563690
107polyol catabolic process (GO:0046174)2.94400818
108regulation of T-helper 2 cell differentiation (GO:0045628)2.93755196
109coenzyme catabolic process (GO:0009109)2.93234637
110intra-Golgi vesicle-mediated transport (GO:0006891)2.93133657
111polyamine biosynthetic process (GO:0006596)2.92766526
112DNA conformation change (GO:0071103)2.90232592
113regulation of phosphoprotein phosphatase activity (GO:0043666)2.89509538
114meiotic cell cycle process (GO:1903046)2.88410951
115alditol metabolic process (GO:0019400)2.85383351
116microtubule-based movement (GO:0007018)2.84793122
117positive regulation of macrophage activation (GO:0043032)2.84491335
118cilium organization (GO:0044782)2.82102410
119positive regulation of guanylate cyclase activity (GO:0031284)2.81540324
120antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.81258327
121intraciliary transport (GO:0042073)2.80850491
122regulation of cilium assembly (GO:1902017)2.80787529
123axoneme assembly (GO:0035082)2.80294415
124negative regulation of organelle assembly (GO:1902116)2.77661683
125cilium assembly (GO:0042384)2.70058773
126synapsis (GO:0007129)2.70055753
127cilium morphogenesis (GO:0060271)2.68842140
128gene silencing by RNA (GO:0031047)2.65443995
129peptidyl-glutamic acid modification (GO:0018200)2.65067464
130mitochondrion degradation (GO:0000422)2.64759046
131cellular component assembly involved in morphogenesis (GO:0010927)2.64209736
132chromatin silencing (GO:0006342)2.60716858
133GTP biosynthetic process (GO:0006183)2.59177241
134lactate metabolic process (GO:0006089)2.51612682
135gene silencing (GO:0016458)2.45103080
136sperm motility (GO:0030317)14.2320054
137fusion of sperm to egg plasma membrane (GO:0007342)12.8191690
138acrosome reaction (GO:0007340)12.4464923
139cell wall macromolecule catabolic process (GO:0016998)11.8933729
140cell wall macromolecule metabolic process (GO:0044036)11.8933729
141sperm-egg recognition (GO:0035036)11.4045381
142acrosome assembly (GO:0001675)10.9997300
143binding of sperm to zona pellucida (GO:0007339)10.4952961
144multicellular organism reproduction (GO:0032504)10.2604287
145cell-cell recognition (GO:0009988)10.2025646

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.61840134
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.88415703
3EZH2_22144423_ChIP-Seq_EOC_Human4.63554099
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.18729540
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.86936964
6MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.35964247
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.00546173
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.88117457
9STAT6_21828071_ChIP-Seq_BEAS2B_Human2.78439717
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.78360528
11BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.67279172
12VDR_22108803_ChIP-Seq_LS180_Human2.58142240
13* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.36403878
14GATA1_26923725_Chip-Seq_HPCs_Mouse2.30579018
15VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.17591761
16CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.14803078
17CTBP1_25329375_ChIP-Seq_LNCAP_Human2.14705625
18EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.07632497
19ZNF274_21170338_ChIP-Seq_K562_Hela2.06295986
20FUS_26573619_Chip-Seq_HEK293_Human2.02336030
21DROSHA_22980978_ChIP-Seq_HELA_Human1.91800171
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.88159862
23RAC3_21632823_ChIP-Seq_H3396_Human1.87533285
24ERA_21632823_ChIP-Seq_H3396_Human1.83693486
25ELK4_26923725_Chip-Seq_MESODERM_Mouse1.83548318
26* FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.77771400
27SOX2_22085726_ChIP-Seq_NPCs_Mouse1.70133139
28FLI1_27457419_Chip-Seq_LIVER_Mouse1.70046183
29STAT1_17558387_ChIP-Seq_HELA_Human1.69543454
30MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.63998744
31KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.62683215
32* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.62549687
33TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.62074138
34SMC4_20622854_ChIP-Seq_HELA_Human1.60448138
35* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.59926076
36TAF2_19829295_ChIP-Seq_ESCs_Human1.58695211
37ER_23166858_ChIP-Seq_MCF-7_Human1.57746520
38GATA3_21867929_ChIP-Seq_CD8_Mouse1.56467667
39WDR5_24793694_ChIP-Seq_LNCAP_Human1.55335664
40MYC_19829295_ChIP-Seq_ESCs_Human1.54776833
41TDRD3_21172665_ChIP-Seq_MCF-7_Human1.53565501
42ARNT_22903824_ChIP-Seq_MCF-7_Human1.53076993
43FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.52869966
44* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.51196651
45* BCL6_27268052_Chip-Seq_Bcells_Human1.50296131
46GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.48909626
47AR_25329375_ChIP-Seq_VCAP_Human1.48431572
48OCT4_20526341_ChIP-Seq_ESCs_Human1.47125802
49P68_20966046_ChIP-Seq_HELA_Human1.46977312
50RBPJ_21746931_ChIP-Seq_IB4_Human1.45245485
51PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.44327868
52PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.44155505
53CBX2_22325352_ChIP-Seq_293T-Rex_Human1.43822841
54AUTS2_25519132_ChIP-Seq_293T-REX_Human1.43679420
55E2F1_20622854_ChIP-Seq_HELA_Human1.42879225
56HNFA_21074721_ChIP-Seq_CACO-2_Human1.41818276
57TP63_22573176_ChIP-Seq_HFKS_Human1.41430527
58CBP_20019798_ChIP-Seq_JUKART_Human1.40944126
59IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.40944126
60P53_21459846_ChIP-Seq_SAOS-2_Human1.40092825
61CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.39742361
62PCGF2_27294783_Chip-Seq_ESCs_Mouse1.39651467
63ETV1_20927104_ChIP-Seq_GIST48_Human1.38147023
64LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.34737040
65SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.33034501
66* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.32696789
67REST_21632747_ChIP-Seq_MESCs_Mouse1.31790076
68ETV2_25802403_ChIP-Seq_MESCs_Mouse1.31540241
69P300_27268052_Chip-Seq_Bcells_Human1.31422287
70TAL1_26923725_Chip-Seq_HPCs_Mouse1.31089849
71ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.30929482
72KDM2B_26808549_Chip-Seq_REH_Human1.30769030
73SMAD3_21741376_ChIP-Seq_ESCs_Human1.30318357
74RAD21_21589869_ChIP-Seq_MESCs_Mouse1.28732333
75PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.28527886
76CEBPB_22108803_ChIP-Seq_LS180_Human1.28205541
77SMAD3_21741376_ChIP-Seq_EPCs_Human1.28204660
78TP53_18474530_ChIP-ChIP_U2OS_Human1.25194760
79MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.23411673
80LXR_22292898_ChIP-Seq_THP-1_Human1.23383057
81KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.22072698
82SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.21898361
83GATA3_21867929_ChIP-Seq_TH1_Mouse1.21674055
84TP63_19390658_ChIP-ChIP_HaCaT_Human1.21315554
85GF1_26923725_Chip-Seq_HPCs_Mouse1.21293056
86CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21196331
87* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.20363971
88KAP1_22055183_ChIP-Seq_ESCs_Mouse1.19110282
89PHF8_20622853_ChIP-Seq_HELA_Human1.18928905
90CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.18395862
91RXRA_24833708_ChIP-Seq_LIVER_Mouse1.16815958
92GATA3_21878914_ChIP-Seq_MCF-7_Human1.16380875
93* P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.15839794
94TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15468193
95* SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14756484
96GATA6_21074721_ChIP-Seq_CACO-2_Human1.14539942
97ERG_20517297_ChIP-Seq_VCAP_Human1.14349426
98FLI1_21867929_ChIP-Seq_TH2_Mouse1.14241857
99MYC_27129775_Chip-Seq_CORNEA_Mouse1.13825107
100TET1_21451524_ChIP-Seq_MESCs_Mouse1.13513047
101TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12506986
102* P300_19829295_ChIP-Seq_ESCs_Human1.12399426
103TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11862941
104CTCF_20526341_ChIP-Seq_ESCs_Human1.11846743
105PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.11780005
106* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.11761213
107POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.10512204
108TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10512204
109* SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.10327296
110* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.10106332
111EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.08780195
112NFE2_27457419_Chip-Seq_LIVER_Mouse1.08469207
113* SPI1_26923725_Chip-Seq_HPCs_Mouse1.08411677
114SMAD4_21799915_ChIP-Seq_A2780_Human1.08013246
115PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.08004061
116GATA1_19941827_ChIP-Seq_MEL86_Mouse1.07830444
117PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.07039822
118NFYA_21822215_ChIP-Seq_K562_Human1.06738028
119EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.06691773
120SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06338907
121STAT3_23295773_ChIP-Seq_U87_Human1.06224887
122RARA_24833708_ChIP-Seq_LIVER_Mouse1.06155181
123GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.05273417
124SMAD4_21741376_ChIP-Seq_HESCs_Human1.05189939
125CTBP2_25329375_ChIP-Seq_LNCAP_Human1.05091320
126SA1_27219007_Chip-Seq_Bcells_Human1.05001081
127PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04992879
128KLF5_20875108_ChIP-Seq_MESCs_Mouse1.04516063
129NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.03976682
130ELF1_20517297_ChIP-Seq_JURKAT_Human1.03564295
131* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.03557645
132ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.02510746
133* RUNX2_22187159_ChIP-Seq_PCA_Human1.01302985
134TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.01049111
135EZH2_27294783_Chip-Seq_ESCs_Mouse1.00540325
136* SMRT_27268052_Chip-Seq_Bcells_Human0.99842694
137OCT1_27270436_Chip-Seq_PROSTATE_Human0.99836433
138KLF4_19829295_ChIP-Seq_ESCs_Human0.99832636
139DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.99634524
140AR_21572438_ChIP-Seq_LNCaP_Human0.99078144
141OCT4_19829295_ChIP-Seq_ESCs_Human0.98613215
142* JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.98412977
143* YY1_22570637_ChIP-Seq_MALME-3M_Human0.97272893
144PCGF2_27294783_Chip-Seq_NPCs_Mouse0.97185224
145CBX2_27304074_Chip-Seq_ESCs_Mouse0.96879483
146* ESET_19884257_ChIP-Seq_ESCs_Mouse0.95478286
147* RUNX1_26923725_Chip-Seq_HPCs_Mouse0.94446593
148SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.94287826
149LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.93458546
150CRX_20693478_ChIP-Seq_RETINA_Mouse0.93436040
151SUZ12_27294783_Chip-Seq_NPCs_Mouse0.93119571
152* SOX11_22085726_ChIP-Seq_ESNs_Mouse0.92516784
153SOX2_21211035_ChIP-Seq_LN229_Human0.92438197
154NANOG_20526341_ChIP-Seq_ESCs_Human0.92349175
155NFYB_21822215_ChIP-Seq_K562_Human0.91126097
156* BCOR_27268052_Chip-Seq_Bcells_Human0.90061440
157CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.90034681
158PHF8_20622854_ChIP-Seq_HELA_Human0.89634075
159RBPJ_22232070_ChIP-Seq_NCS_Mouse0.89114672
160* FLI1_21867929_ChIP-Seq_CD8_Mouse0.87025836
161NANOG_18555785_Chip-Seq_ESCs_Mouse0.85929608
162CTCF_27219007_Chip-Seq_Bcells_Human0.85449539
163NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.84617381
164PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.84532079
165TBL1_22424771_ChIP-Seq_293T_Human0.84279552
166SMAD4_21741376_ChIP-Seq_EPCs_Human0.84213652
167TAF15_26573619_Chip-Seq_HEK293_Human0.83768410
168PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.83695816

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.05352083
2MP0001929_abnormal_gametogenesis5.52254336
3MP0008877_abnormal_DNA_methylation4.03481672
4MP0002210_abnormal_sex_determination3.36457984
5MP0002161_abnormal_fertility/fecundity3.31201052
6MP0001348_abnormal_lacrimal_gland3.05757625
7MP0005670_abnormal_white_adipose3.00645630
8MP0001145_abnormal_male_reproductive2.85713491
9MP0000653_abnormal_sex_gland2.46116700
10MP0003718_maternal_effect2.43893969
11MP0002653_abnormal_ependyma_morphology2.37291327
12MP0000678_abnormal_parathyroid_gland2.26606862
13MP0005410_abnormal_fertilization16.5507850
14MP0001485_abnormal_pinna_reflex1.76258241
15MP0005451_abnormal_body_composition1.69274104
16MP0002160_abnormal_reproductive_system1.61462687
17MP0003646_muscle_fatigue1.58260513
18MP0002132_abnormal_respiratory_system1.57286216
19MP0005423_abnormal_somatic_nervous1.55509897
20MP0005310_abnormal_salivary_gland1.55296344
21MP0005379_endocrine/exocrine_gland_phen1.48246771
22MP0005623_abnormal_meninges_morphology1.45820142
23MP0001486_abnormal_startle_reflex1.45324985
24MP0004233_abnormal_muscle_weight1.43215635
25MP0002822_catalepsy1.34082391
26MP0002249_abnormal_larynx_morphology1.32163613
27MP0002282_abnormal_trachea_morphology1.21064566
28MP0004859_abnormal_synaptic_plasticity1.19498861
29MP0002138_abnormal_hepatobiliary_system1.15840037
30MP0001963_abnormal_hearing_physiology1.13254600
31MP0009053_abnormal_anal_canal1.12816155
32MP0005395_other_phenotype1.08353051
33MP0001765_abnormal_ion_homeostasis1.08300766
34MP0002735_abnormal_chemical_nociception1.04335735
35MP0001984_abnormal_olfaction0.97862965
36MP0002127_abnormal_cardiovascular_syste0.92564302
37MP0000026_abnormal_inner_ear0.92309921
38MP0002234_abnormal_pharynx_morphology0.90354712
39MP0008995_early_reproductive_senescence0.86207052
40MP0000955_abnormal_spinal_cord0.85131496
41MP0008058_abnormal_DNA_repair0.81389489
42MP0005647_abnormal_sex_gland0.80564680
43MP0005389_reproductive_system_phenotype0.78865573
44MP0008569_lethality_at_weaning0.77476135
45MP0003115_abnormal_respiratory_system0.77457427
46MP0002067_abnormal_sensory_capabilities0.77088837
47MP0005377_hearing/vestibular/ear_phenot0.76425284
48MP0003878_abnormal_ear_physiology0.76425284
49MP0004510_myositis0.74015266
50MP0005248_abnormal_Harderian_gland0.73346514
51MP0003011_delayed_dark_adaptation0.72192020
52MP0002557_abnormal_social/conspecific_i0.69123960
53MP0009046_muscle_twitch0.68304582
54MP0005083_abnormal_biliary_tract0.67726310
55MP0001905_abnormal_dopamine_level0.67700497
56MP0009697_abnormal_copulation0.65915226
57MP0003077_abnormal_cell_cycle0.65903786
58MP0005666_abnormal_adipose_tissue0.64222293
59MP0000681_abnormal_thyroid_gland0.62683368
60MP0005636_abnormal_mineral_homeostasis0.61237248
61MP0004085_abnormal_heartbeat0.60015967
62MP0000049_abnormal_middle_ear0.59265549
63MP0003329_amyloid_beta_deposits0.58880558
64MP0000569_abnormal_digit_pigmentation0.56084077
65MP0005167_abnormal_blood-brain_barrier0.54842502
66MP0000358_abnormal_cell_content/0.54450670
67MP0001666_abnormal_nutrient_absorption0.53311808
68MP0009278_abnormal_bone_marrow0.52933594
69MP0002572_abnormal_emotion/affect_behav0.51833529
70MP0002272_abnormal_nervous_system0.50881497
71MP0010094_abnormal_chromosome_stability0.50653992
72MP0001764_abnormal_homeostasis0.50307140
73MP0001324_abnormal_eye_pigmentation0.50047729
74MP0005397_hematopoietic_system_phenotyp0.49921738
75MP0001545_abnormal_hematopoietic_system0.49921738
76MP0001293_anophthalmia0.49667105
77MP0004036_abnormal_muscle_relaxation0.48757107
78MP0002269_muscular_atrophy0.48661650
79MP0000003_abnormal_adipose_tissue0.48171941
80MP0002733_abnormal_thermal_nociception0.47990553
81MP0009745_abnormal_behavioral_response0.45978700
82MP0003699_abnormal_female_reproductive0.45937414
83MP0001879_abnormal_lymphatic_vessel0.44994242
84MP0003137_abnormal_impulse_conducting0.44723384
85MP0000534_abnormal_ureter_morphology0.43927607
86MP0003950_abnormal_plasma_membrane0.42869195
87MP0001270_distended_abdomen0.42572037
88MP0002928_abnormal_bile_duct0.42063437
89MP0010329_abnormal_lipoprotein_level0.41802957
90MP0005253_abnormal_eye_physiology0.41535907
91MP0001440_abnormal_grooming_behavior0.41319089
92MP0002736_abnormal_nociception_after0.40392891
93MP0002734_abnormal_mechanical_nocicepti0.40059744
94MP0000516_abnormal_urinary_system0.39596072
95MP0005367_renal/urinary_system_phenotyp0.39596072
96MP0005535_abnormal_body_temperature0.38725469
97MP0004484_altered_response_of0.38645810
98MP0003111_abnormal_nucleus_morphology0.38399440
99MP0006036_abnormal_mitochondrial_physio0.37835964
100MP0005551_abnormal_eye_electrophysiolog0.37107298
101MP0009115_abnormal_fat_cell0.36500023
102MP0000613_abnormal_salivary_gland0.36325971
103MP0000230_abnormal_systemic_arterial0.36007001
104MP0000470_abnormal_stomach_morphology0.35243413
105MP0005391_vision/eye_phenotype0.33689863
106MP0003942_abnormal_urinary_system0.33677538
107MP0003936_abnormal_reproductive_system0.33622603
108MP0003879_abnormal_hair_cell0.33101107
109MP0000249_abnormal_blood_vessel0.32904973
110MP0001501_abnormal_sleep_pattern0.32644980
111MP0001730_embryonic_growth_arrest0.32372483
112MP0001970_abnormal_pain_threshold0.32177739
113MP0004133_heterotaxia0.31904146
114MP0003786_premature_aging0.29520383
115MP0002971_abnormal_brown_adipose0.28933150
116MP0000604_amyloidosis0.28731221
117MP0008007_abnormal_cellular_replicative0.28551381
118MP0004811_abnormal_neuron_physiology0.28162027
119MP0003861_abnormal_nervous_system0.25406487
120MP0008057_abnormal_DNA_replication0.24090180
121MP0005375_adipose_tissue_phenotype0.24026912
122MP0003633_abnormal_nervous_system0.23772403
123MP0002295_abnormal_pulmonary_circulatio0.23656875
124MP0001119_abnormal_female_reproductive0.23563087
125MP0008961_abnormal_basal_metabolism0.23255953
126MP0003948_abnormal_gas_homeostasis0.22692549
127MP0002152_abnormal_brain_morphology0.21935639
128MP0002169_no_abnormal_phenotype0.21711817
129MP0003787_abnormal_imprinting0.21638396
130MP0002873_normal_phenotype0.21468378
131MP0002092_abnormal_eye_morphology0.20706351
132MP0001727_abnormal_embryo_implantation0.20698845
133MP0002139_abnormal_hepatobiliary_system0.20632051
134MP0000751_myopathy0.20140634
135MP0001661_extended_life_span0.19878620
136MP0001849_ear_inflammation0.19754272
137MP0003631_nervous_system_phenotype0.19309259
138MP0004019_abnormal_vitamin_homeostasis0.19082789
139MP0004742_abnormal_vestibular_system0.19063622
140MP0004043_abnormal_pH_regulation0.18508164
141MP0001968_abnormal_touch/_nociception0.18481715
142MP0006035_abnormal_mitochondrial_morpho0.17890157
143MP0004808_abnormal_hematopoietic_stem0.17117345
144MP0000313_abnormal_cell_death0.16566676
145MP0002084_abnormal_developmental_patter0.16457361
146MP0004270_analgesia0.16304040
147MP0003045_fibrosis0.15600793
148MP0010307_abnormal_tumor_latency0.14958730
149MP0002229_neurodegeneration0.14892193
150MP0002909_abnormal_adrenal_gland0.14179983
151MP0002693_abnormal_pancreas_physiology0.14125716
152MP0000001_mammalian_phenotype0.13970395
153MP0003959_abnormal_lean_body0.13917988
154MP0005380_embryogenesis_phenotype0.13117549
155MP0001672_abnormal_embryogenesis/_devel0.13117549
156MP0002405_respiratory_system_inflammati0.12738030
157MP0005365_abnormal_bile_salt0.11759229

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.18491752
2Abnormal respiratory epithelium morphology (HP:0012253)9.15040965
3Abnormal respiratory motile cilium morphology (HP:0005938)9.15040965
4Rhinitis (HP:0012384)7.53136916
5Severe visual impairment (HP:0001141)7.45647077
6Chronic bronchitis (HP:0004469)7.24738486
7Infertility (HP:0000789)7.19906739
8Abnormal ciliary motility (HP:0012262)7.09406963
9Nasal polyposis (HP:0100582)6.47853819
10Chronic hepatic failure (HP:0100626)5.86535805
11Abnormality of the nasal mucosa (HP:0000433)5.33024105
12Hyperkalemia (HP:0002153)4.98223098
13Male infertility (HP:0003251)4.86499806
14Resting tremor (HP:0002322)4.73675565
15Bronchitis (HP:0012387)4.68571222
16Bony spicule pigmentary retinopathy (HP:0007737)4.58955677
17Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.58285456
18Bronchiectasis (HP:0002110)4.50070833
19Attenuation of retinal blood vessels (HP:0007843)4.48223406
20Cone-rod dystrophy (HP:0000548)4.43784744
21Abnormality of macular pigmentation (HP:0008002)4.27558086
22Nephronophthisis (HP:0000090)4.26988596
23Hypoalphalipoproteinemia (HP:0003233)3.82813961
24Menstrual irregularities (HP:0000858)3.76330545
25Abnormal spermatogenesis (HP:0008669)3.67508304
26Facial shape deformation (HP:0011334)3.63974777
27Potter facies (HP:0002009)3.63974777
28Aplasia/Hypoplasia of the earlobes (HP:0009906)3.63046515
29Hypoplasia of the thymus (HP:0000778)3.61601665
30Progressive sensorineural hearing impairment (HP:0000408)3.61392991
31Recurrent otitis media (HP:0000403)3.36164537
32Renovascular hypertension (HP:0100817)3.27617112
33Abnormal rod and cone electroretinograms (HP:0008323)3.25278535
34Postural instability (HP:0002172)3.24118824
35Abnormality of the renal medulla (HP:0100957)3.21261175
36Amelogenesis imperfecta (HP:0000705)3.14769623
37Recurrent sinusitis (HP:0011108)3.10742380
38Insulin-resistant diabetes mellitus (HP:0000831)3.05084615
39Impulsivity (HP:0100710)2.98687990
40Recurrent bronchitis (HP:0002837)2.97793046
41Hypoplastic ischia (HP:0003175)2.92534874
42Portal hypertension (HP:0001409)2.88204795
43Enlarged epiphyses (HP:0010580)2.88114568
44Progressive cerebellar ataxia (HP:0002073)2.86010893
45Abnormality of dental color (HP:0011073)2.85858815
46Tubulointerstitial nephritis (HP:0001970)2.84918362
47Abnormal gallbladder physiology (HP:0012438)2.65583425
48Cholecystitis (HP:0001082)2.65583425
49Abnormality of potassium homeostasis (HP:0011042)2.65483033
50Abnormality of the hepatic vasculature (HP:0006707)2.64779030
51Abnormality of the ischium (HP:0003174)2.64298062
52Gonadotropin excess (HP:0000837)2.62698007
53Tubular atrophy (HP:0000092)2.60854649
54Generalized aminoaciduria (HP:0002909)2.56581496
55Abnormality of midbrain morphology (HP:0002418)2.47057424
56Molar tooth sign on MRI (HP:0002419)2.47057424
57Tubulointerstitial abnormality (HP:0001969)2.46879207
58Abnormality of the costochondral junction (HP:0000919)2.45318896
59Increased purine levels (HP:0004368)2.43103625
60Hyperuricemia (HP:0002149)2.43103625
61Subcapsular cataract (HP:0000523)2.35649136
62Unilateral renal agenesis (HP:0000122)2.35309713
63Abnormality of the aortic arch (HP:0012303)2.33594952
64Progressive hearing impairment (HP:0001730)2.30902453
65Azoospermia (HP:0000027)2.30629535
66Osteomalacia (HP:0002749)2.26427245
67Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.22356258
68Dyschromatopsia (HP:0007641)2.19302149
69Medial flaring of the eyebrow (HP:0010747)2.18418984
70Myokymia (HP:0002411)2.14251292
71Spastic tetraparesis (HP:0001285)2.11562389
72Ventricular tachycardia (HP:0004756)2.08852993
73Intellectual disability, moderate (HP:0002342)2.07628347
74Polyuria (HP:0000103)2.06132259
75Choroideremia (HP:0001139)2.04981839
76Hypophosphatemic rickets (HP:0004912)2.02901946
77Tubulointerstitial fibrosis (HP:0005576)2.02392127
78Absent/shortened dynein arms (HP:0200106)13.2066678
79Dynein arm defect of respiratory motile cilia (HP:0012255)13.2066678
80Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.9661326
81Recurrent pneumonia (HP:0006532)1.99271753
82Flattened epiphyses (HP:0003071)1.98476380
83Hypolipoproteinemia (HP:0010981)1.93057914
84Focal segmental glomerulosclerosis (HP:0000097)1.90937499
85Abnormality of the parathyroid morphology (HP:0011766)1.90532236
86Decreased central vision (HP:0007663)1.89613472
87Hyponatremia (HP:0002902)1.87537716
88Optic nerve hypoplasia (HP:0000609)1.87362059
89Widely patent fontanelles and sutures (HP:0004492)1.85752347
90Upper limb muscle weakness (HP:0003484)1.83985046
91Heterotopia (HP:0002282)1.83526628
92Postaxial foot polydactyly (HP:0001830)1.81524587
93Hypoplasia of the capital femoral epiphysis (HP:0003090)1.80928854
94Insulin resistance (HP:0000855)1.79719761
95Abnormal drinking behavior (HP:0030082)1.78849814
96Polydipsia (HP:0001959)1.78849814
97Stage 5 chronic kidney disease (HP:0003774)1.78346068
98Abnormality of the lower motor neuron (HP:0002366)1.77642574
99Abnormal biliary tract physiology (HP:0012439)1.75682109
100Bile duct proliferation (HP:0001408)1.75682109
101Renal Fanconi syndrome (HP:0001994)1.75526904
102Hemorrhage of the eye (HP:0011885)1.74860798
103Abnormality of chloride homeostasis (HP:0011422)1.74288102
104Occipital encephalocele (HP:0002085)1.73387872
105Neurofibrillary tangles (HP:0002185)1.72175455
106Bradycardia (HP:0001662)1.71341643
107Obsessive-compulsive behavior (HP:0000722)1.71038115
108Photophobia (HP:0000613)1.69512205
109Epiphyseal dysplasia (HP:0002656)1.68181105
110Congenital hepatic fibrosis (HP:0002612)1.68175527
111Short ribs (HP:0000773)1.67983513
112Abnormality of the epiphysis of the femoral head (HP:0010574)1.67866968
113Bell-shaped thorax (HP:0001591)1.66651430
114Horizontal nystagmus (HP:0000666)1.65789909
115Recurrent corneal erosions (HP:0000495)1.63963290
116Acanthosis nigricans (HP:0000956)1.62842921
117Sandal gap (HP:0001852)1.61479416
118Abnormality of the renal cortex (HP:0011035)1.60962173
119Fibular hypoplasia (HP:0003038)1.60564405
120Abnormality of purine metabolism (HP:0004352)1.60390465
121Abnormality of renal excretion (HP:0011036)1.60309612
122Double outlet right ventricle (HP:0001719)1.59727445
123Congenital malformation of the right heart (HP:0011723)1.59727445
124Abnormality of dentin (HP:0010299)1.56186794
125Decreased electroretinogram (ERG) amplitude (HP:0000654)1.54843299
126Oculomotor apraxia (HP:0000657)1.54405343
127Amyotrophic lateral sclerosis (HP:0007354)1.50637598
128Renal dysplasia (HP:0000110)1.49549652
129Abnormality of the dental root (HP:0006486)1.45357063
130Taurodontia (HP:0000679)1.45357063
131Abnormality of permanent molar morphology (HP:0011071)1.45357063
132Absent epiphyses (HP:0010577)1.43353582
133Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.43353582
134Deformed sella turcica (HP:0002681)1.40852780
135Cerebral inclusion bodies (HP:0100314)1.40267009
136Aplasia/Hypoplasia of the lens (HP:0008063)1.38904729
137Hemiparesis (HP:0001269)1.38530397
138Postaxial hand polydactyly (HP:0001162)1.38302956
139Asymmetric septal hypertrophy (HP:0001670)1.38187845
140Abnormal urine output (HP:0012590)1.37654263
141Facial cleft (HP:0002006)1.37648803
142Bundle branch block (HP:0011710)1.37350995
143Exercise-induced myalgia (HP:0003738)1.35865346
144Abnormality of the dental pulp (HP:0006479)1.35542799
145Broad distal phalanx of finger (HP:0009836)1.35424521
146Cystic liver disease (HP:0006706)1.35417059
147Easy fatigability (HP:0003388)1.35096256
148Abnormality of molar (HP:0011077)1.33252898
149Abnormality of molar morphology (HP:0011070)1.33252898
150Loss of speech (HP:0002371)1.30083815
151Myoglobinuria (HP:0002913)1.29564470
152Absent frontal sinuses (HP:0002688)1.28905273
153Impaired proprioception (HP:0010831)1.28230712
154Hypercholesterolemia (HP:0003124)1.27699935
155Short femoral neck (HP:0100864)1.27273222
156Cerebellar dysplasia (HP:0007033)1.24841166
157Short thorax (HP:0010306)1.23673360
158Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.23402913
159Truncal obesity (HP:0001956)1.22130226
160Constricted visual fields (HP:0001133)1.21934737
161Chronic sinusitis (HP:0011109)1.21497908
162Nephropathy (HP:0000112)1.20970949
163Fatigable weakness (HP:0003473)1.18556681
164Abnormality of the neuromuscular junction (HP:0003398)1.18556681
165J-shaped sella turcica (HP:0002680)1.18143036
166Sensory axonal neuropathy (HP:0003390)1.15444304
167Neoplasm of the heart (HP:0100544)1.14388728

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK47.65524057
2PDK37.65524057
3TESK16.90979780
4PRKD35.51857226
5PDK24.93111070
6ICK4.87146412
7DDR23.71192308
8BRD43.61668214
9INSRR3.48153598
10PLK23.30928757
11MAP4K22.44769601
12PTK2B2.30408850
13WNK42.26016809
14PNCK2.15612882
15STK392.09948953
16MST1R1.98133127
17STK381.94643647
18PIK3CG1.90264053
19DYRK1B1.81280065
20NEK21.70301403
21PDK11.17145707
22CDK71.10418099
23AKT31.10189700
24MAPK151.07938429
25DYRK30.94223669
26KSR20.93682206
27SIK20.93001486
28MAP3K90.91743765
29CAMK1D0.91736010
30WNK10.91532834
31TYRO30.90659252
32PASK0.81877765
33EEF2K0.78850599
34MAP3K110.75890025
35PDPK10.75246588
36CCNB10.74307480
37IRAK10.69845443
38RIPK40.67110447
39STK30.66600222
40TESK20.65337725
41TTK0.63555317
42CAMK1G0.63183747
43MAP2K20.62684000
44PINK10.60968091
45MET0.58225239
46MAP3K20.57917261
47LATS20.57867865
48RPS6KA20.57617605
49CAMK10.56532026
50CHEK20.54983170
51SGK4940.48754265
52SGK2230.48754265
53CDK30.48697377
54MAP2K60.48624595
55ROCK10.48205381
56ARAF0.48161002
57TIE10.47449729
58UHMK10.44225282
59NTRK20.43889440
60MAP3K80.43093962
61PAK10.42532108
62MAPK10.41254579
63PRKAA20.41029545
64LATS10.40877996
65BMPR1B0.40862243
66CHEK10.39913247
67NTRK30.39350306
68IRAK20.38777394
69MUSK0.38597177
70PRKCG0.35723624
71STK38L0.34713497
72OXSR10.34429634
73PAK20.33965679
74MAP3K100.33738747
75PAK40.33609408
76SGK10.32872705
77LMTK20.32405534
78MTOR0.32096676
79MARK10.30955631
80MAPKAPK50.29944044
81MARK20.29443597
82ATR0.28725041
83ATM0.28137272
84WEE10.28067972
85CAMK40.26366209
86CAMKK10.25770786
87RPS6KL10.25225594
88RPS6KC10.25225594
89MAP3K40.24858476
90RPS6KA60.24390617
91MAPK140.24201505
92CDK190.23712671
93CDC70.22630749
94PRKAA10.21195870
95MAPK100.20522959
96JAK30.20520613
97NEK60.19678621
98PRKCZ0.18128320
99RPS6KB10.16221738
100AKT10.14923042
101CDK150.14674169
102PRKCQ0.14056527
103SGK20.13488053
104MAPK110.13434003
105PLK10.13266897
106BRSK20.13171445
107PKN10.12073122
108CDK180.11996770
109PLK40.11692223
110CDK11A0.11239304
111RPS6KA10.09344408
112BRSK10.08413605
113MINK10.08228016
114GSK3B0.07567237
115CSF1R0.06910598
116CDK140.06826436
117CSNK2A10.06634333
118PRKG20.06561607
119BRAF0.06360169
120PRKACA0.06035411
121STK100.05848183
122CDK60.05036059
123TNIK0.04685702
124MAPK90.04677829
125CSNK1D0.03744267
126CDK20.03715293
127CLK10.03692366
128PIM10.03452434
129CDK10.03246998
130CDK120.02931150
131STK110.02851723
132WNK30.02527062
133MAPK80.02429359
134PRKACG0.01692422
135MARK30.01504908
136PAK60.00885498
137PRKCB0.00860401
138PRKCD0.00809804
139CSNK2A20.00684958
140CAMK2A0.00502692
141PRKG10.00216058
142EPHB10.00156403
143PDGFRB-0.0365676
144CSK-0.0346427
145PRKDC-0.0309635
146PRKACB-0.0306540
147MAP3K1-0.0255223
148RPS6KA3-0.0250804
149EGFR-0.0177122
150AURKA-0.0091467
151CDK4-0.0072988
152PRKCA-0.0064884
153TRIB3-0.0014393

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000726.76843246
2Fatty acid biosynthesis_Homo sapiens_hsa000614.74074109
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.47944369
4Olfactory transduction_Homo sapiens_hsa047403.55626805
5Pyruvate metabolism_Homo sapiens_hsa006203.27892452
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.24945295
7Vitamin B6 metabolism_Homo sapiens_hsa007503.20671331
8Linoleic acid metabolism_Homo sapiens_hsa005913.12753890
9Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.73837364
10Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.65910216
11Glucagon signaling pathway_Homo sapiens_hsa049222.58544462
12Carbohydrate digestion and absorption_Homo sapiens_hsa049732.52845199
13Propanoate metabolism_Homo sapiens_hsa006402.40377066
14Butanoate metabolism_Homo sapiens_hsa006502.24589282
15Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.17055521
16Basal transcription factors_Homo sapiens_hsa030222.14727300
17Selenocompound metabolism_Homo sapiens_hsa004502.08993625
18Glycerolipid metabolism_Homo sapiens_hsa005611.98012044
19PPAR signaling pathway_Homo sapiens_hsa033201.88572929
20Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.85112217
21Fructose and mannose metabolism_Homo sapiens_hsa000511.79369501
22Glycerophospholipid metabolism_Homo sapiens_hsa005641.77298046
23Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.74485377
24Dorso-ventral axis formation_Homo sapiens_hsa043201.74041149
25Oocyte meiosis_Homo sapiens_hsa041141.58339939
26Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.53729203
27Fat digestion and absorption_Homo sapiens_hsa049751.53690206
28Amphetamine addiction_Homo sapiens_hsa050311.50430143
29Mineral absorption_Homo sapiens_hsa049781.47376780
30Fatty acid metabolism_Homo sapiens_hsa012121.47146914
31Fatty acid degradation_Homo sapiens_hsa000711.47136952
32Phenylalanine metabolism_Homo sapiens_hsa003601.45890782
33Pentose phosphate pathway_Homo sapiens_hsa000301.44419137
34Ether lipid metabolism_Homo sapiens_hsa005651.42995710
35Carbon metabolism_Homo sapiens_hsa012001.29644862
36Cardiac muscle contraction_Homo sapiens_hsa042601.25833023
37Fanconi anemia pathway_Homo sapiens_hsa034601.24064496
38Antigen processing and presentation_Homo sapiens_hsa046121.22378055
39Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.16420131
40Phototransduction_Homo sapiens_hsa047441.14449735
41Glycosaminoglycan degradation_Homo sapiens_hsa005311.11663691
42Cysteine and methionine metabolism_Homo sapiens_hsa002701.09183874
43mRNA surveillance pathway_Homo sapiens_hsa030151.05160472
44Renin secretion_Homo sapiens_hsa049241.04996633
45Hedgehog signaling pathway_Homo sapiens_hsa043401.00984417
46Huntingtons disease_Homo sapiens_hsa050160.99152734
47Purine metabolism_Homo sapiens_hsa002300.97574166
48Morphine addiction_Homo sapiens_hsa050320.97217229
49Type I diabetes mellitus_Homo sapiens_hsa049400.96717101
50Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.94712372
51Glutathione metabolism_Homo sapiens_hsa004800.92359168
52Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.88443702
53Adipocytokine signaling pathway_Homo sapiens_hsa049200.87666365
54Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.87253677
55RNA transport_Homo sapiens_hsa030130.86199017
56Arachidonic acid metabolism_Homo sapiens_hsa005900.85647852
57Arginine biosynthesis_Homo sapiens_hsa002200.85599573
58Arginine and proline metabolism_Homo sapiens_hsa003300.84624985
59Insulin secretion_Homo sapiens_hsa049110.84601321
60Collecting duct acid secretion_Homo sapiens_hsa049660.82664041
61Estrogen signaling pathway_Homo sapiens_hsa049150.79265204
62Nicotine addiction_Homo sapiens_hsa050330.78937407
63Primary bile acid biosynthesis_Homo sapiens_hsa001200.78921472
64Biosynthesis of amino acids_Homo sapiens_hsa012300.77144533
65Autoimmune thyroid disease_Homo sapiens_hsa053200.76006950
66Allograft rejection_Homo sapiens_hsa053300.75349583
67Chemical carcinogenesis_Homo sapiens_hsa052040.74209247
68Long-term potentiation_Homo sapiens_hsa047200.73726430
69Thyroid hormone synthesis_Homo sapiens_hsa049180.73317421
70Bile secretion_Homo sapiens_hsa049760.70308650
71cGMP-PKG signaling pathway_Homo sapiens_hsa040220.68928016
72Influenza A_Homo sapiens_hsa051640.67269441
73Glutamatergic synapse_Homo sapiens_hsa047240.66731617
74Legionellosis_Homo sapiens_hsa051340.66723493
75Central carbon metabolism in cancer_Homo sapiens_hsa052300.65997938
76Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.65598232
77Graft-versus-host disease_Homo sapiens_hsa053320.64091496
78Viral myocarditis_Homo sapiens_hsa054160.62534185
79Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.62338037
80ABC transporters_Homo sapiens_hsa020100.61912229
81Tyrosine metabolism_Homo sapiens_hsa003500.59790215
82Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.58757439
83Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.58619633
84Maturity onset diabetes of the young_Homo sapiens_hsa049500.54581067
85Aldosterone synthesis and secretion_Homo sapiens_hsa049250.53028137
86Pancreatic secretion_Homo sapiens_hsa049720.52208611
87Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.50586085
88Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.50381659
89Tight junction_Homo sapiens_hsa045300.50270732
90Serotonergic synapse_Homo sapiens_hsa047260.49269540
91AMPK signaling pathway_Homo sapiens_hsa041520.48591227
92Endocytosis_Homo sapiens_hsa041440.48478773
93MAPK signaling pathway_Homo sapiens_hsa040100.48135875
94Salivary secretion_Homo sapiens_hsa049700.46706345
95Protein digestion and absorption_Homo sapiens_hsa049740.46506677
96Retinol metabolism_Homo sapiens_hsa008300.45995110
97Renin-angiotensin system_Homo sapiens_hsa046140.45847816
98Vascular smooth muscle contraction_Homo sapiens_hsa042700.45664699
99Systemic lupus erythematosus_Homo sapiens_hsa053220.44921157
100Calcium signaling pathway_Homo sapiens_hsa040200.43780955
101Synaptic vesicle cycle_Homo sapiens_hsa047210.42838570
102Nitrogen metabolism_Homo sapiens_hsa009100.42192246
103Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.41036625
104Cholinergic synapse_Homo sapiens_hsa047250.38910846
105VEGF signaling pathway_Homo sapiens_hsa043700.38078272
106Gastric acid secretion_Homo sapiens_hsa049710.37612447
107Thyroid hormone signaling pathway_Homo sapiens_hsa049190.37308727
108Acute myeloid leukemia_Homo sapiens_hsa052210.34269697
109GABAergic synapse_Homo sapiens_hsa047270.33863552
110Phosphatidylinositol signaling system_Homo sapiens_hsa040700.33494797
111Pentose and glucuronate interconversions_Homo sapiens_hsa000400.32849171
112Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.32772340
113Pyrimidine metabolism_Homo sapiens_hsa002400.32483365
114Metabolic pathways_Homo sapiens_hsa011000.32382033
115Inositol phosphate metabolism_Homo sapiens_hsa005620.31084871
116Oxytocin signaling pathway_Homo sapiens_hsa049210.29485443
117cAMP signaling pathway_Homo sapiens_hsa040240.28026172
118ECM-receptor interaction_Homo sapiens_hsa045120.27548531
119Taste transduction_Homo sapiens_hsa047420.26585271
120Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.26147457
121Alcoholism_Homo sapiens_hsa050340.25725813
122Sulfur metabolism_Homo sapiens_hsa009200.25447169
123Transcriptional misregulation in cancer_Homo sapiens_hsa052020.25164126
124Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.24319580
125Circadian entrainment_Homo sapiens_hsa047130.22377598
126Cocaine addiction_Homo sapiens_hsa050300.22228324
127Prolactin signaling pathway_Homo sapiens_hsa049170.19971428
128Viral carcinogenesis_Homo sapiens_hsa052030.19803743
129Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.18469000
130Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.15754371
131Adherens junction_Homo sapiens_hsa045200.15692388
132Jak-STAT signaling pathway_Homo sapiens_hsa046300.14244976
133B cell receptor signaling pathway_Homo sapiens_hsa046620.13307821
134HIF-1 signaling pathway_Homo sapiens_hsa040660.12492471
135Basal cell carcinoma_Homo sapiens_hsa052170.11793743
136Wnt signaling pathway_Homo sapiens_hsa043100.11411255
137Type II diabetes mellitus_Homo sapiens_hsa049300.11216080
138N-Glycan biosynthesis_Homo sapiens_hsa005100.10834365
139Insulin resistance_Homo sapiens_hsa049310.07756971

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