TCP11L1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)5.77044360
2synaptic vesicle endocytosis (GO:0048488)4.68910708
3hemidesmosome assembly (GO:0031581)4.59634604
4regulation of short-term neuronal synaptic plasticity (GO:0048172)4.46040918
5cell adhesion mediated by integrin (GO:0033627)4.40303313
6piRNA metabolic process (GO:0034587)4.32008046
7synaptic vesicle exocytosis (GO:0016079)4.30021382
8regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.23411160
9positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.14403978
10dendrite morphogenesis (GO:0048813)4.13094079
11neuron cell-cell adhesion (GO:0007158)4.09531525
12cell migration in hindbrain (GO:0021535)4.08538668
13glutamate secretion (GO:0014047)3.99881038
14cerebellar Purkinje cell differentiation (GO:0021702)3.94759760
15synaptic vesicle maturation (GO:0016188)3.90773281
16protein K11-linked deubiquitination (GO:0035871)3.86139424
17protein localization to synapse (GO:0035418)3.84811996
18wound healing, spreading of epidermal cells (GO:0035313)3.81509180
19G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.80664015
20regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.80459676
21regulation of hippo signaling (GO:0035330)3.76228664
22nuclear pore complex assembly (GO:0051292)3.75451161
23membrane depolarization during action potential (GO:0086010)3.69420993
24positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.66442513
25central nervous system projection neuron axonogenesis (GO:0021952)3.65303268
26nuclear pore organization (GO:0006999)3.61564619
27regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.59198083
28cellular potassium ion homeostasis (GO:0030007)3.58251729
29vocalization behavior (GO:0071625)3.57147609
30regulation of respiratory system process (GO:0044065)3.56626079
31protein targeting to lysosome (GO:0006622)3.54670319
32establishment of protein localization to vacuole (GO:0072666)3.54670319
33protein targeting to vacuole (GO:0006623)3.54670319
34ionotropic glutamate receptor signaling pathway (GO:0035235)3.52249208
35glutamate receptor signaling pathway (GO:0007215)3.51004322
36cerebral cortex radially oriented cell migration (GO:0021799)3.50396048
37urinary tract smooth muscle contraction (GO:0014848)3.48057511
38behavioral response to nicotine (GO:0035095)3.41914139
39neuromuscular synaptic transmission (GO:0007274)3.40448562
40regulation of synaptic vesicle exocytosis (GO:2000300)3.40444692
41pyrimidine dimer repair (GO:0006290)3.38751541
42positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.36880178
43response to auditory stimulus (GO:0010996)3.35759757
44regulation of glutamate receptor signaling pathway (GO:1900449)3.35342067
45synaptic transmission, glutamatergic (GO:0035249)3.33394423
46synapse assembly (GO:0007416)3.31743674
47regulation of synaptic vesicle transport (GO:1902803)3.26179459
48single strand break repair (GO:0000012)3.24439816
49glycerophospholipid catabolic process (GO:0046475)3.23525839
50cytoplasmic mRNA processing body assembly (GO:0033962)3.19386013
51postsynaptic membrane organization (GO:0001941)3.18729028
52negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.18184840
53positive regulation of dendritic spine morphogenesis (GO:0061003)3.18057430
54positive regulation of synaptic transmission, GABAergic (GO:0032230)3.17872462
55neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.16204162
56synapsis (GO:0007129)3.15458857
57neuronal action potential propagation (GO:0019227)3.14065440
58regulation of neuronal synaptic plasticity (GO:0048168)3.13836756
59locomotory exploration behavior (GO:0035641)3.13544510
60heparin biosynthetic process (GO:0030210)3.13059296
61heparin metabolic process (GO:0030202)3.13059296
62negative regulation of microtubule polymerization (GO:0031115)3.11187143
63neuronal action potential (GO:0019228)3.10882957
64innervation (GO:0060384)3.09877970
65L-amino acid import (GO:0043092)3.09652592
66establishment of protein localization to Golgi (GO:0072600)3.09422557
67lipid translocation (GO:0034204)3.08288146
68phospholipid translocation (GO:0045332)3.08288146
69positive regulation of mitochondrial fission (GO:0090141)3.08269780
70neurofilament cytoskeleton organization (GO:0060052)3.07902518
71neuromuscular process controlling posture (GO:0050884)3.06987385
72regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.06479877
73adult walking behavior (GO:0007628)3.06053461
74behavioral response to pain (GO:0048266)3.05808186
75regulation of synapse structural plasticity (GO:0051823)3.05659027
76mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.04042744
77positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.04042744
78axonal fasciculation (GO:0007413)3.03169347
79regulation of synaptic transmission, glutamatergic (GO:0051966)3.02893681
80axon cargo transport (GO:0008088)3.02839303
81neuron-neuron synaptic transmission (GO:0007270)3.02711117
82regulation of respiratory gaseous exchange (GO:0043576)3.02672773
83dosage compensation (GO:0007549)3.01610572
84regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)3.01116292
85positive regulation of potassium ion transmembrane transport (GO:1901381)3.00727344
86membrane hyperpolarization (GO:0060081)3.00536144
87pore complex assembly (GO:0046931)2.99994104
88retinal ganglion cell axon guidance (GO:0031290)2.99081841
89negative regulation of vascular permeability (GO:0043116)2.98487259
90establishment of synaptic vesicle localization (GO:0097480)2.94981283
91synaptic vesicle transport (GO:0048489)2.94981283
92membrane depolarization (GO:0051899)2.92718827
93establishment of mitochondrion localization (GO:0051654)2.91874348
94regulation of long-term neuronal synaptic plasticity (GO:0048169)2.91345995
95gamma-aminobutyric acid transport (GO:0015812)2.89861139
96cerebellar granule cell differentiation (GO:0021707)2.89188647
97startle response (GO:0001964)2.88558593
98membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.87625750
99proline transport (GO:0015824)2.87440635
100auditory behavior (GO:0031223)2.86808792
101cell differentiation in hindbrain (GO:0021533)2.86158645
102neurotransmitter secretion (GO:0007269)2.85107861
103neuron recognition (GO:0008038)2.85106003
104snRNA transcription (GO:0009301)2.85025617
105histone H3-K36 demethylation (GO:0070544)2.84717621
106regulation of meiosis I (GO:0060631)2.83955646
107pyrimidine nucleobase catabolic process (GO:0006208)2.83606170
108layer formation in cerebral cortex (GO:0021819)2.83057609
109central nervous system neuron axonogenesis (GO:0021955)2.82732170
110negative regulation of synaptic transmission, GABAergic (GO:0032229)2.81634310
111mitochondrion transport along microtubule (GO:0047497)2.81586761
112establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.81586761
113protein targeting to Golgi (GO:0000042)2.77881485
114regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.77776266
115glucocorticoid receptor signaling pathway (GO:0042921)2.77471566
116exploration behavior (GO:0035640)2.77131265
117regulation of neurotransmitter secretion (GO:0046928)2.75333970
118dendritic spine morphogenesis (GO:0060997)2.73755425
119fibroblast migration (GO:0010761)2.73696705
120male meiosis (GO:0007140)2.73599398
121positive regulation of dendritic spine development (GO:0060999)2.72584293
122regulation of postsynaptic membrane potential (GO:0060078)2.72098203
123glycine transport (GO:0015816)2.71743432
124presynaptic membrane assembly (GO:0097105)2.71223946
125ganglion development (GO:0061548)2.70586616
126cranial nerve morphogenesis (GO:0021602)2.69032965
127substrate-dependent cell migration (GO:0006929)2.67577926
128positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.67527736
129negative regulation of mast cell activation (GO:0033004)2.66591306
130detection of temperature stimulus (GO:0016048)2.66415149
131negative regulation of dendrite development (GO:2000171)2.66410228
132retrograde transport, vesicle recycling within Golgi (GO:0000301)2.65981416
133growth hormone receptor signaling pathway (GO:0060396)2.65968371
134mitotic sister chromatid cohesion (GO:0007064)2.64979988
135regulation of synaptic transmission, GABAergic (GO:0032228)2.64472916
136vesicle transport along microtubule (GO:0047496)2.63172774
137negative regulation of meiosis (GO:0045835)2.62862689
138regulation of excitatory postsynaptic membrane potential (GO:0060079)2.62815800
139DNA methylation involved in gamete generation (GO:0043046)2.62737786
140early endosome to late endosome transport (GO:0045022)2.62498865
141cell communication by electrical coupling (GO:0010644)2.61339046
142regulation of synapse assembly (GO:0051963)2.60524674
143establishment of vesicle localization (GO:0051650)2.59914023
144neurotransmitter transport (GO:0006836)2.59890063
145synaptic vesicle docking involved in exocytosis (GO:0016081)2.59475708
146regulation of cAMP-dependent protein kinase activity (GO:2000479)2.59278123
147sphingosine metabolic process (GO:0006670)2.57638952
148sequestering of extracellular ligand from receptor (GO:0035581)2.54728179
149nerve growth factor signaling pathway (GO:0038180)2.54600584
150protein localization to cell surface (GO:0034394)2.54187125
151negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.53941348
152protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.50882365
153Golgi transport vesicle coating (GO:0048200)2.49601170
154COPI coating of Golgi vesicle (GO:0048205)2.49601170
155COPII vesicle coating (GO:0048208)2.49510040
156protein K48-linked deubiquitination (GO:0071108)2.48616132
157activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)2.48598131
158ribonucleoprotein complex disassembly (GO:0032988)2.48452416
159sprouting angiogenesis (GO:0002040)2.48318360
160regulation of protein polyubiquitination (GO:1902914)2.47936184
161mesodermal cell differentiation (GO:0048333)2.45611989
162rRNA catabolic process (GO:0016075)2.45444406
163regulation of NFAT protein import into nucleus (GO:0051532)2.45439198
164UDP-N-acetylglucosamine metabolic process (GO:0006047)2.45396092
165cellular response to vitamin D (GO:0071305)2.45214666
166embryonic process involved in female pregnancy (GO:0060136)2.44861737
167regulation of clathrin-mediated endocytosis (GO:2000369)2.43355594
168glomerular visceral epithelial cell development (GO:0072015)2.42543213
169establishment of nucleus localization (GO:0040023)2.41403991
170import into cell (GO:0098657)2.40659199
171meiotic chromosome segregation (GO:0045132)2.40110374
172inactivation of MAPK activity (GO:0000188)2.38839769
173organelle transport along microtubule (GO:0072384)2.36810129
174oogenesis (GO:0048477)2.36558191
175germ cell migration (GO:0008354)2.34219164
176Golgi to plasma membrane protein transport (GO:0043001)2.33703725
177type B pancreatic cell proliferation (GO:0044342)2.33368509
178microtubule nucleation (GO:0007020)2.31950379
179regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.31168936
180macroautophagy (GO:0016236)2.30603714
181heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.30535051
182negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.30209178
183wound healing, spreading of cells (GO:0044319)2.29554898
184Golgi to plasma membrane transport (GO:0006893)2.28972140
185regulation of mitochondrial fission (GO:0090140)2.28074311
186mesenchymal-epithelial cell signaling (GO:0060638)2.27593301
187endoplasmic reticulum organization (GO:0007029)2.27353456
188interkinetic nuclear migration (GO:0022027)2.26823376
189cell-substrate junction assembly (GO:0007044)2.26450215
190gene silencing by RNA (GO:0031047)2.26194852
191magnesium ion transport (GO:0015693)2.25226136
192regulation of establishment of cell polarity (GO:2000114)2.24995199
193positive regulation of vasculogenesis (GO:2001214)2.22880804
194regulation of centriole replication (GO:0046599)2.22782893

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human4.68333043
2EZH2_22144423_ChIP-Seq_EOC_Human4.20862566
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.43073337
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.34649007
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.78565727
6BRD4_25478319_ChIP-Seq_HGPS_Human2.74216822
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.71204217
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.61630371
9SALL1_21062744_ChIP-ChIP_HESCs_Human2.50766802
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.48110768
11IGF1R_20145208_ChIP-Seq_DFB_Human2.42840959
12REST_21632747_ChIP-Seq_MESCs_Mouse2.37741714
13ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.35212709
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.32909830
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.32448627
16RNF2_18974828_ChIP-Seq_MESCs_Mouse2.30175952
17EZH2_18974828_ChIP-Seq_MESCs_Mouse2.30175952
18JARID2_20075857_ChIP-Seq_MESCs_Mouse2.29533728
19CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.22509721
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.19057959
21MTF2_20144788_ChIP-Seq_MESCs_Mouse2.18590021
22WT1_19549856_ChIP-ChIP_CCG9911_Human2.18233871
23DROSHA_22980978_ChIP-Seq_HELA_Human2.14670057
24* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.13371269
25ZFP57_27257070_Chip-Seq_ESCs_Mouse2.12888714
26AR_21572438_ChIP-Seq_LNCaP_Human2.10023868
27RNF2_27304074_Chip-Seq_ESCs_Mouse2.07910590
28EZH2_27294783_Chip-Seq_ESCs_Mouse2.03589637
29* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.02866392
30SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.02669455
31FUS_26573619_Chip-Seq_HEK293_Human2.01616476
32CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.01056674
33PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.99103278
34SUZ12_27294783_Chip-Seq_ESCs_Mouse1.98468102
35CJUN_26792858_Chip-Seq_BT549_Human1.95258100
36NRF2_20460467_ChIP-Seq_MEFs_Mouse1.93666130
37NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.93666130
38* SMAD4_21799915_ChIP-Seq_A2780_Human1.84772957
39SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.82817440
40Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.82583482
41SMAD_19615063_ChIP-ChIP_OVARY_Human1.82403220
42TAF15_26573619_Chip-Seq_HEK293_Human1.81976525
43BMI1_23680149_ChIP-Seq_NPCS_Mouse1.79578120
44SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.79061447
45SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.79061447
46FLI1_27457419_Chip-Seq_LIVER_Mouse1.77832639
47P300_19829295_ChIP-Seq_ESCs_Human1.71881049
48CTBP2_25329375_ChIP-Seq_LNCAP_Human1.70346128
49TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.69604850
50REST_18959480_ChIP-ChIP_MESCs_Mouse1.65815561
51PCGF2_27294783_Chip-Seq_ESCs_Mouse1.65697334
52CBX2_27304074_Chip-Seq_ESCs_Mouse1.63223716
53PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.61383644
54GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.59978480
55JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.56185724
56STAT3_23295773_ChIP-Seq_U87_Human1.55723404
57EWS_26573619_Chip-Seq_HEK293_Human1.51987664
58CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.51352546
59PCGF2_27294783_Chip-Seq_NPCs_Mouse1.50253229
60CTBP1_25329375_ChIP-Seq_LNCAP_Human1.50106961
61* RNF2_27304074_Chip-Seq_NSC_Mouse1.49035735
62AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.48408222
63RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.43765036
64VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.43504336
65SMAD3_21741376_ChIP-Seq_EPCs_Human1.43226444
66KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.42708171
67CTNNB1_20460455_ChIP-Seq_HCT116_Human1.41731533
68* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40746097
69CDX2_19796622_ChIP-Seq_MESCs_Mouse1.40404575
70PIAS1_25552417_ChIP-Seq_VCAP_Human1.39710531
71POU3F2_20337985_ChIP-ChIP_501MEL_Human1.39595549
72GATA2_21666600_ChIP-Seq_HMVEC_Human1.39292504
73EP300_21415370_ChIP-Seq_HL-1_Mouse1.38504522
74JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.38388591
75NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.36965005
76AR_25329375_ChIP-Seq_VCAP_Human1.36856496
77TOP2B_26459242_ChIP-Seq_MCF-7_Human1.36391105
78IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.36163639
79CBP_20019798_ChIP-Seq_JUKART_Human1.36163639
80EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.36096926
81ELK1_19687146_ChIP-ChIP_HELA_Human1.35652368
82NR3C1_23031785_ChIP-Seq_PC12_Mouse1.35487440
83* TP63_23658742_ChIP-Seq_EP156T_Human1.32900509
84SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32601350
85FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.32018693
86* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.31797980
87SUZ12_27294783_Chip-Seq_NPCs_Mouse1.30785549
88RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.28969399
89NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.28896516
90AHR_22903824_ChIP-Seq_MCF-7_Human1.28132848
91ARNT_22903824_ChIP-Seq_MCF-7_Human1.27326970
92IKZF1_21737484_ChIP-ChIP_HCT116_Human1.26039591
93TCF4_23295773_ChIP-Seq_U87_Human1.25705717
94YAP1_20516196_ChIP-Seq_MESCs_Mouse1.25328707
95RARB_27405468_Chip-Seq_BRAIN_Mouse1.24322419
96ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.24135423
97SOX2_21211035_ChIP-Seq_LN229_Gbm1.24011358
98* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23960042
99EGR1_19374776_ChIP-ChIP_THP-1_Human1.23917348
100* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23749036
101FLI1_21867929_ChIP-Seq_TH2_Mouse1.23412978
102PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.23183389
103* NANOG_18555785_Chip-Seq_ESCs_Mouse1.23096582
104EZH2_27294783_Chip-Seq_NPCs_Mouse1.21865836
105ZNF217_24962896_ChIP-Seq_MCF-7_Human1.21220875
106ERG_21242973_ChIP-ChIP_JURKAT_Human1.20183649
107ZNF274_21170338_ChIP-Seq_K562_Hela1.18835591
108NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.18153164
109AR_19668381_ChIP-Seq_PC3_Human1.16303646
110HIF1A_21447827_ChIP-Seq_MCF-7_Human1.16155709
111* E2F1_18555785_Chip-Seq_ESCs_Mouse1.15699390
112TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15578085
113CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.14172876
114MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.13496096
115RING1B_27294783_Chip-Seq_NPCs_Mouse1.12454962
116P53_22127205_ChIP-Seq_FIBROBLAST_Human1.11644917
117FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.11032427
118* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.10113158
119JUN_21703547_ChIP-Seq_K562_Human1.09633375
120RING1B_27294783_Chip-Seq_ESCs_Mouse1.09539984
121RUNX2_22187159_ChIP-Seq_PCA_Human1.08606242
122TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06831112
123UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05689566
124TFEB_21752829_ChIP-Seq_HELA_Human1.05175931
125* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.04500485
126NFE2_27457419_Chip-Seq_LIVER_Mouse1.04009986
127* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.03611360
128NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03279742
129* CMYC_18555785_Chip-Seq_ESCs_Mouse1.02803140
130TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02698375
131POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.02698375
132* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.01715716
133CDX2_22108803_ChIP-Seq_LS180_Human1.01555232
134PADI4_21655091_ChIP-ChIP_MCF-7_Human1.00951472
135SOX9_26525672_Chip-Seq_HEART_Mouse1.00870714
136FOXM1_26456572_ChIP-Seq_MCF-7_Human0.99629168
137TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.99252141
138TCF4_18268006_ChIP-ChIP_LS174T_Human0.98958450
139CRX_20693478_ChIP-Seq_RETINA_Mouse0.98410981
140ER_23166858_ChIP-Seq_MCF-7_Human0.98198665
141SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.97920816
142STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.97579311
143* P53_22387025_ChIP-Seq_ESCs_Mouse0.97499554
144IRF1_19129219_ChIP-ChIP_H3396_Human0.97328503
145RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.97319326
146SMAD3_21741376_ChIP-Seq_ESCs_Human0.96983835
147PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95958194
148SALL4_18804426_ChIP-ChIP_XEN_Mouse0.95931204
149KDM2B_26808549_Chip-Seq_REH_Human0.95503885
150TP53_16413492_ChIP-PET_HCT116_Human0.94114961
151* TP53_18474530_ChIP-ChIP_U2OS_Human0.93688447
152* SUZ12_18555785_Chip-Seq_ESCs_Mouse0.92429259

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.40756381
2MP0008438_abnormal_cutaneous_collagen4.13260981
3MP0002735_abnormal_chemical_nociception3.58204528
4MP0001968_abnormal_touch/_nociception3.45391688
5MP0005645_abnormal_hypothalamus_physiol3.33953427
6MP0000569_abnormal_digit_pigmentation3.32162138
7MP0003880_abnormal_central_pattern3.29610409
8MP0008057_abnormal_DNA_replication3.21902043
9MP0005275_abnormal_skin_tensile3.14202016
10MP0006276_abnormal_autonomic_nervous3.10619433
11MP0004270_analgesia3.08295191
12MP0003950_abnormal_plasma_membrane2.85641553
13MP0003635_abnormal_synaptic_transmissio2.83487467
14MP0008877_abnormal_DNA_methylation2.76446152
15MP0002736_abnormal_nociception_after2.66491579
16MP0001984_abnormal_olfaction2.61795815
17MP0010352_gastrointestinal_tract_polyps2.51310136
18MP0003122_maternal_imprinting2.49885327
19MP0009046_muscle_twitch2.46163106
20MP0002734_abnormal_mechanical_nocicepti2.42848771
21MP0004858_abnormal_nervous_system2.42029334
22MP0000383_abnormal_hair_follicle2.41194984
23MP0002063_abnormal_learning/memory/cond2.34895634
24MP0000778_abnormal_nervous_system2.34167817
25MP0005423_abnormal_somatic_nervous2.31722194
26MP0002733_abnormal_thermal_nociception2.26835542
27MP0002184_abnormal_innervation2.19047875
28MP0005646_abnormal_pituitary_gland2.18700420
29MP0003566_abnormal_cell_adhesion2.14810733
30MP0006292_abnormal_olfactory_placode2.13200504
31MP0010386_abnormal_urinary_bladder2.12203298
32MP0005171_absent_coat_pigmentation2.07549391
33MP0002064_seizures2.06654357
34MP0002572_abnormal_emotion/affect_behav2.06451299
35MP0009745_abnormal_behavioral_response2.04669616
36MP0002067_abnormal_sensory_capabilities2.02184720
37MP0002272_abnormal_nervous_system1.99841327
38MP0001970_abnormal_pain_threshold1.96734317
39MP0001486_abnormal_startle_reflex1.95622707
40MP0010678_abnormal_skin_adnexa1.92061582
41MP0006054_spinal_hemorrhage1.82060293
42MP0005623_abnormal_meninges_morphology1.79624859
43MP0003091_abnormal_cell_migration1.78470916
44MP0000427_abnormal_hair_cycle1.75161169
45MP0001188_hyperpigmentation1.70575870
46MP0001502_abnormal_circadian_rhythm1.67970424
47MP0000955_abnormal_spinal_cord1.66176793
48MP0002557_abnormal_social/conspecific_i1.62918945
49MP0002102_abnormal_ear_morphology1.62826967
50MP0004811_abnormal_neuron_physiology1.62517899
51MP0010030_abnormal_orbit_morphology1.61930745
52MP0002009_preneoplasia1.61824275
53MP0002638_abnormal_pupillary_reflex1.57884693
54MP0003045_fibrosis1.57604719
55MP0001958_emphysema1.56642953
56MP0005084_abnormal_gallbladder_morpholo1.54938305
57MP0002877_abnormal_melanocyte_morpholog1.54568593
58MP0005023_abnormal_wound_healing1.51743958
59MP0005386_behavior/neurological_phenoty1.50810923
60MP0004924_abnormal_behavior1.50810923
61MP0004742_abnormal_vestibular_system1.50342661
62MP0001243_abnormal_dermal_layer1.48171370
63MP0002060_abnormal_skin_morphology1.46904892
64MP0005394_taste/olfaction_phenotype1.46837516
65MP0005499_abnormal_olfactory_system1.46837516
66MP0002882_abnormal_neuron_morphology1.43662199
67MP0004272_abnormal_basement_membrane1.40784045
68MP0008058_abnormal_DNA_repair1.39423578
69MP0000647_abnormal_sebaceous_gland1.39116837
70MP0000566_synostosis1.35719058
71MP0001440_abnormal_grooming_behavior1.34726316
72MP0001299_abnormal_eye_distance/1.33010317
73MP0000015_abnormal_ear_pigmentation1.32935391
74MP0004142_abnormal_muscle_tone1.32461393
75MP0002751_abnormal_autonomic_nervous1.31526651
76MP0003656_abnormal_erythrocyte_physiolo1.28922313
77MP0001501_abnormal_sleep_pattern1.23919351
78MP0005551_abnormal_eye_electrophysiolog1.20931050
79MP0003787_abnormal_imprinting1.16795405
80MP0002332_abnormal_exercise_endurance1.15844944
81MP0000013_abnormal_adipose_tissue1.14620986
82MP0000631_abnormal_neuroendocrine_gland1.13040961
83MP0003279_aneurysm1.12613754
84MP0003941_abnormal_skin_development1.11850679
85MP0003172_abnormal_lysosome_physiology1.11241066
86MP0005409_darkened_coat_color1.11103735
87MP0003121_genomic_imprinting1.11013544
88MP0002928_abnormal_bile_duct1.10828548
89MP0002066_abnormal_motor_capabilities/c1.08953314
90MP0000358_abnormal_cell_content/1.08936184
91MP0001542_abnormal_bone_strength1.08620258
92MP0002752_abnormal_somatic_nervous1.08578925
93MP0001986_abnormal_taste_sensitivity1.08514238
94MP0003879_abnormal_hair_cell1.07511568
95MP0003890_abnormal_embryonic-extraembry1.06868456
96MP0005621_abnormal_cell_physiology1.06063748
97MP0008569_lethality_at_weaning1.05864930
98MP0008789_abnormal_olfactory_epithelium1.03700416
99MP0004147_increased_porphyrin_level1.01681874
100MP0005174_abnormal_tail_pigmentation1.01677980
101MP0005248_abnormal_Harderian_gland1.01152133
102MP0010368_abnormal_lymphatic_system1.00818414
103MP0008007_abnormal_cellular_replicative1.00131605
104MP0003705_abnormal_hypodermis_morpholog0.99866113
105MP0002896_abnormal_bone_mineralization0.99670217
106MP0003329_amyloid_beta_deposits0.99548254
107MP0002229_neurodegeneration0.99345511
108MP0001191_abnormal_skin_condition0.99037965
109MP0002152_abnormal_brain_morphology0.98823487
110MP0004134_abnormal_chest_morphology0.98177864
111MP0002938_white_spotting0.97335537
112MP0003634_abnormal_glial_cell0.97175829
113MP0009697_abnormal_copulation0.96657091
114MP0000538_abnormal_urinary_bladder0.95863525
115MP0003633_abnormal_nervous_system0.95481650
116MP0008995_early_reproductive_senescence0.95163791
117MP0005384_cellular_phenotype0.95011783
118MP0004885_abnormal_endolymph0.92186101
119MP0001348_abnormal_lacrimal_gland0.90746877
120MP0005187_abnormal_penis_morphology0.88863866
121MP0010771_integument_phenotype0.88699741
122MP0005167_abnormal_blood-brain_barrier0.88335691
123MP0001963_abnormal_hearing_physiology0.86653993
124MP0010307_abnormal_tumor_latency0.86277751
125MP0004133_heterotaxia0.86131902
126MP0005253_abnormal_eye_physiology0.85624606
127MP0001529_abnormal_vocalization0.85527838
128MP0003631_nervous_system_phenotype0.85379671
129MP0000026_abnormal_inner_ear0.85271778
130MP0002138_abnormal_hepatobiliary_system0.83422740
131MP0001905_abnormal_dopamine_level0.82046063
132MP0001915_intracranial_hemorrhage0.81841282
133MP0003448_altered_tumor_morphology0.81163355
134MP0002177_abnormal_outer_ear0.80288359
135MP0002168_other_aberrant_phenotype0.79483811
136MP0000681_abnormal_thyroid_gland0.77899820
137MP0002249_abnormal_larynx_morphology0.77531932
138MP0005503_abnormal_tendon_morphology0.77049745
139MP0000049_abnormal_middle_ear0.76540410
140MP0003252_abnormal_bile_duct0.76318900
141MP0005058_abnormal_lysosome_morphology0.76270066
142MP0000767_abnormal_smooth_muscle0.76112321
143MP0003861_abnormal_nervous_system0.75706456
144MP0002006_tumorigenesis0.74696516
145MP0004808_abnormal_hematopoietic_stem0.74682034
146MP0004233_abnormal_muscle_weight0.73643314
147MP0003300_gastrointestinal_ulcer0.73500570
148MP0002090_abnormal_vision0.72703134
149MP0000372_irregular_coat_pigmentation0.72147397
150MP0003183_abnormal_peptide_metabolism0.71651168
151MP0001216_abnormal_epidermal_layer0.70701049
152MP0002163_abnormal_gland_morphology0.70062756
153MP0000467_abnormal_esophagus_morphology0.69543594
154MP0009780_abnormal_chondrocyte_physiolo0.69105927
155MP0003632_abnormal_nervous_system0.68285847
156MP0002295_abnormal_pulmonary_circulatio0.68236472
157MP0006072_abnormal_retinal_apoptosis0.67594994
158MP0001324_abnormal_eye_pigmentation0.67560441
159MP0000003_abnormal_adipose_tissue0.67483199
160MP0002822_catalepsy0.67480475
161MP0008932_abnormal_embryonic_tissue0.67417764
162MP0002234_abnormal_pharynx_morphology0.66337423
163MP0002269_muscular_atrophy0.65235763
164MP0002084_abnormal_developmental_patter0.64526217
165MP0005257_abnormal_intraocular_pressure0.64084838
166MP0000579_abnormal_nail_morphology0.63096640
167MP0000920_abnormal_myelination0.62355991
168MP0005195_abnormal_posterior_eye0.62027596
169MP0000749_muscle_degeneration0.59928973
170MP0003385_abnormal_body_wall0.59653734
171MP0003938_abnormal_ear_development0.59025775
172MP0001661_extended_life_span0.58627660

Predicted human phenotypes

RankGene SetZ-score
1Febrile seizures (HP:0002373)4.87923442
2Focal motor seizures (HP:0011153)4.79230454
3Myokymia (HP:0002411)4.60691767
4Action tremor (HP:0002345)4.23810227
5Progressive cerebellar ataxia (HP:0002073)4.12521516
6Epileptic encephalopathy (HP:0200134)4.05480751
7Focal seizures (HP:0007359)3.97230098
8Polyphagia (HP:0002591)3.88157190
9Failure to thrive in infancy (HP:0001531)3.71940152
10Ulnar claw (HP:0001178)3.62182822
11Supranuclear gaze palsy (HP:0000605)3.47649783
12Termporal pattern (HP:0011008)3.47371582
13Insidious onset (HP:0003587)3.47371582
14Degeneration of the lateral corticospinal tracts (HP:0002314)3.15058413
15Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.15058413
16Shoulder girdle muscle weakness (HP:0003547)3.13182459
17Autoamputation (HP:0001218)3.11323651
18Excessive salivation (HP:0003781)3.07934892
19Drooling (HP:0002307)3.07934892
20Absence seizures (HP:0002121)3.07160233
21Atrophic scars (HP:0001075)3.03894579
22Aqueductal stenosis (HP:0002410)2.95928808
23Truncal ataxia (HP:0002078)2.87089433
24Generalized tonic-clonic seizures (HP:0002069)2.85509120
25Visual hallucinations (HP:0002367)2.84049579
26Congenital stationary night blindness (HP:0007642)2.81692707
27Abnormality of the hip-girdle musculature (HP:0001445)2.78289164
28Abnormality of the musculature of the pelvis (HP:0001469)2.78289164
29Abnormal eating behavior (HP:0100738)2.74535212
30Dialeptic seizures (HP:0011146)2.73914580
31Follicular hyperkeratosis (HP:0007502)2.70371674
32Pelvic girdle muscle weakness (HP:0003749)2.66686081
33Spondylolisthesis (HP:0003302)2.59170184
34Broad ribs (HP:0000885)2.53297697
35Absent speech (HP:0001344)2.51539318
36Ankle clonus (HP:0011448)2.50884844
37Wormian bones (HP:0002645)2.50539808
38Protruding tongue (HP:0010808)2.48600247
39Atonic seizures (HP:0010819)2.46016673
40Epileptiform EEG discharges (HP:0011182)2.44565765
41Premature rupture of membranes (HP:0001788)2.41872433
42Hypothermia (HP:0002045)2.38645656
43EEG with generalized epileptiform discharges (HP:0011198)2.38353731
44Disproportionate short-trunk short stature (HP:0003521)2.34636391
45Blue irides (HP:0000635)2.34050318
46Gaze-evoked nystagmus (HP:0000640)2.33953680
47Entropion (HP:0000621)2.33386165
48Hyperventilation (HP:0002883)2.32412534
49Hand muscle atrophy (HP:0009130)2.32342640
50Sleep apnea (HP:0010535)2.30408916
51Hip dysplasia (HP:0001385)2.29429644
52Severe visual impairment (HP:0001141)2.29406442
53Limb dystonia (HP:0002451)2.29324173
54Progressive inability to walk (HP:0002505)2.29132846
55Abnormality of salivation (HP:0100755)2.27679351
56Esotropia (HP:0000565)2.27237719
57Urinary glycosaminoglycan excretion (HP:0003541)2.26462897
58Mucopolysacchariduria (HP:0008155)2.26462897
59Poor eye contact (HP:0000817)2.26382433
60Mutism (HP:0002300)2.26344947
61Broad-based gait (HP:0002136)2.25394929
62Genetic anticipation (HP:0003743)2.25040892
63Ankle contracture (HP:0006466)2.19387052
64Agitation (HP:0000713)2.17241562
65Poikiloderma (HP:0001029)2.14463623
66Abnormality of mucopolysaccharide metabolism (HP:0011020)2.12317564
67Abnormality of polysaccharide metabolism (HP:0011012)2.12317564
68Abnormality of glycosaminoglycan metabolism (HP:0004371)2.12317564
69Fibular aplasia (HP:0002990)2.11492225
70Hemiparesis (HP:0001269)2.11024069
71Exotropia (HP:0000577)2.07983590
72Pheochromocytoma (HP:0002666)2.07784751
73Mild short stature (HP:0003502)2.05836263
74Medulloblastoma (HP:0002885)2.05633156
75Hypsarrhythmia (HP:0002521)2.04085801
76Abnormality of the odontoid process (HP:0003310)2.03002271
77Urinary urgency (HP:0000012)2.02662941
78Hypoplasia of the brainstem (HP:0002365)2.02047853
79Aplasia/Hypoplasia of the brainstem (HP:0007362)2.02047853
80Dysmetric saccades (HP:0000641)2.01113566
81Aortic aneurysm (HP:0004942)2.01062289
82Open mouth (HP:0000194)2.00020229
83Impaired vibration sensation in the lower limbs (HP:0002166)1.98702685
84Postural instability (HP:0002172)1.96978148
85Septo-optic dysplasia (HP:0100842)1.96018647
86Facial diplegia (HP:0001349)1.95968190
87Tented upper lip vermilion (HP:0010804)1.95674351
88Specific learning disability (HP:0001328)1.95050200
89Hypoplasia of the odontoid process (HP:0003311)1.94801322
90Distal lower limb amyotrophy (HP:0008944)1.94222292
91Depression (HP:0000716)1.92833050
92Lower limb muscle weakness (HP:0007340)1.92713399
93Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.92568833
94Small hand (HP:0200055)1.92156574
95Narrow palate (HP:0000189)1.92020221
96Lower limb amyotrophy (HP:0007210)1.91187274
97Cervical subluxation (HP:0003308)1.90790157
98Protrusio acetabuli (HP:0003179)1.90768244
99Steppage gait (HP:0003376)1.90455550
100Abnormal social behavior (HP:0012433)1.89348558
101Impaired social interactions (HP:0000735)1.89348558
102Clumsiness (HP:0002312)1.89070892
103Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.88723662
104Cubitus valgus (HP:0002967)1.88357375
105Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.88034911
106Inappropriate behavior (HP:0000719)1.87614999
107Milia (HP:0001056)1.86901248
108Mesomelia (HP:0003027)1.86549328
109Papillary thyroid carcinoma (HP:0002895)1.86349849
110Limb-girdle muscle weakness (HP:0003325)1.86130625
111Upper limb muscle weakness (HP:0003484)1.84383082
112Wrist flexion contracture (HP:0001239)1.84019204
113Impaired vibratory sensation (HP:0002495)1.83875319
114Distal upper limb amyotrophy (HP:0007149)1.83193322
115Upper limb amyotrophy (HP:0009129)1.83193322
116Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.83094792
117Vertebral arch anomaly (HP:0008438)1.81487185
118Aortic dissection (HP:0002647)1.79713810
119Bowel diverticulosis (HP:0005222)1.78155090
120Spastic gait (HP:0002064)1.78106333
121Albinism (HP:0001022)1.77919559
122Bradycardia (HP:0001662)1.77798651
123Neuroendocrine neoplasm (HP:0100634)1.77532181
124Abnormality of macular pigmentation (HP:0008002)1.76761820
125Growth hormone deficiency (HP:0000824)1.76496864
126Lissencephaly (HP:0001339)1.76484521
127Soft skin (HP:0000977)1.76324977
128Absent frontal sinuses (HP:0002688)1.76184196
129Alacrima (HP:0000522)1.75085190
130Generalized hypopigmentation of hair (HP:0011358)1.74563746
131Thoracolumbar scoliosis (HP:0002944)1.74254017
132Abnormality of the corticospinal tract (HP:0002492)1.73888860
133Onycholysis (HP:0001806)1.73302364
134Thick nail (HP:0001805)1.73256660
135Decreased lacrimation (HP:0000633)1.72274955
136Abnormality of the antihelix (HP:0009738)1.71835354
137Scanning speech (HP:0002168)1.70488183
138Narrow forehead (HP:0000341)1.69593343
139Ovoid vertebral bodies (HP:0003300)1.69232631
140Mitral stenosis (HP:0001718)1.68822593
141Absent septum pellucidum (HP:0001331)1.68746897
142Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.68552694
143Gait imbalance (HP:0002141)1.68370523
144Abnormal auditory evoked potentials (HP:0006958)1.68054715
145Hypoventilation (HP:0002791)1.67386675
146Iris hypopigmentation (HP:0007730)1.66909267
147Widely spaced teeth (HP:0000687)1.66581878
148Submucous cleft hard palate (HP:0000176)1.66403288
149Anosmia (HP:0000458)1.66083497
150Generalized hypopigmentation (HP:0007513)1.66044807
151Astrocytoma (HP:0009592)1.65447536
152Abnormality of the astrocytes (HP:0100707)1.65447536
153Aplasia/Hypoplasia of the fovea (HP:0008060)1.65018980
154Hypoplasia of the fovea (HP:0007750)1.65018980
155Dysdiadochokinesis (HP:0002075)1.65008551
156Lower limb hyperreflexia (HP:0002395)1.64837807
157Fair hair (HP:0002286)1.64619030
158Bladder diverticulum (HP:0000015)1.63632706
159Abnormality of dentin (HP:0010299)1.63291975
160Abnormality of the lower motor neuron (HP:0002366)1.63282776
161Genu recurvatum (HP:0002816)1.63160517
162Choroideremia (HP:0001139)1.62779007
163Retinal dysplasia (HP:0007973)1.62288685
164Segmental peripheral demyelination/remyelination (HP:0003481)1.62253383
165Ependymoma (HP:0002888)1.62249776
166Dysmetria (HP:0001310)1.62221026
167Narrow nasal bridge (HP:0000446)1.61312354
168Spastic paraplegia (HP:0001258)1.61199593
169Optic nerve hypoplasia (HP:0000609)1.61024608
170Paraplegia (HP:0010550)1.60758936
171Insomnia (HP:0100785)1.60608348
172Urinary bladder sphincter dysfunction (HP:0002839)1.60477322
173Vascular tortuosity (HP:0004948)1.60180743
174Nephrogenic diabetes insipidus (HP:0009806)1.60041264
175Increased number of teeth (HP:0011069)1.59631152
176Inability to walk (HP:0002540)1.57992832
177Megalencephaly (HP:0001355)1.57499168
178Fragile skin (HP:0001030)1.57039251
179Osteolytic defects of the hand bones (HP:0009699)1.57038621
180Osteolytic defects of the phalanges of the hand (HP:0009771)1.57038621

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.76682195
2MAP4K24.12047458
3SIK33.51197866
4NEK13.37206881
5MARK13.13711826
6MINK12.80107424
7MAP3K122.74628355
8FRK2.73030872
9CDK122.53796811
10RPS6KA42.48838551
11MAP3K92.40293781
12MAP2K72.33850323
13MAP3K42.18907794
14NTRK22.18352915
15CASK2.02803623
16FLT31.92496339
17MAP2K41.91291136
18TRIM281.90036508
19BCR1.89253090
20TNIK1.87062346
21NEK91.84089667
22ACVR1B1.79343174
23PAK61.78606793
24PRPF4B1.75635215
25NTRK11.73983763
26LATS21.65446810
27MAPK131.64079093
28KSR11.61729510
29YES11.61126408
30SGK21.60862594
31MET1.56507719
32SGK2231.52596842
33SGK4941.52596842
34PINK11.43843506
35EPHA41.39513911
36ERBB31.37215924
37LATS11.28248038
38MARK21.27928248
39MAP3K21.25150552
40RIPK41.23779049
41CDK51.20884769
42PHKG21.20452182
43PHKG11.20452182
44CAMKK21.18607370
45SIK21.18005177
46WNK31.16257921
47PDGFRA1.16201815
48CLK11.12757581
49SRPK11.09773847
50CDK61.07891845
51TGFBR21.05893904
52UHMK11.05759934
53BRSK21.05649440
54PDGFRB1.02883542
55SGK31.00441596
56LMTK20.99837261
57DYRK20.99272714
58TRPM70.96007974
59PDK20.95759130
60PRKCG0.95713419
61RPS6KA50.94946899
62PNCK0.93434068
63RAF10.93183253
64PLK40.92646120
65CAMK1G0.92057884
66ICK0.89094571
67CAMK1D0.88925415
68INSRR0.88206672
69PTK20.88070757
70DDR20.87844178
71MATK0.87100014
72DAPK10.86658206
73MAP3K110.85277504
74PBK0.83008718
75CAMK40.82463879
76ADRBK20.81888434
77CDC42BPA0.81571234
78CAMK2A0.79676864
79STK38L0.78531073
80PAK20.75949407
81PTK2B0.74654135
82PLK20.74101553
83WNK10.73523326
84GRK70.70713809
85CAMKK10.68725772
86FER0.68192979
87EIF2AK30.67900247
88PRKCE0.67609146
89SGK10.67606460
90ERBB20.66679363
91CDK180.66575938
92SCYL20.66496577
93IRAK10.66441918
94RET0.65602254
95PKN20.65199309
96DAPK20.65082636
97PIK3CG0.64514562
98PRKCZ0.63725015
99ZAK0.63134525
100GRK50.63121406
101CSNK1G20.62369763
102TAOK20.62222848
103FES0.60943301
104PRKD20.59703725
105IRAK20.59575465
106DYRK30.59471246
107CAMK2B0.58189324
108DYRK1A0.57860754
109CDK140.57817354
110LIMK10.57152953
111PAK30.56574578
112IRAK30.56432016
113RPS6KA20.56104702
114ERBB40.54705649
115JAK10.54632586
116STK380.54597149
117MAPK100.52649325
118PIM20.52506656
119AKT30.51957646
120MAP3K60.51453575
121CAMK2D0.50626264
122IRAK40.49898447
123CDK30.49842201
124CDK150.48941470
125MAPK110.48179494
126CAMK10.47630642
127HIPK20.47443537
128EPHB20.45566056
129BRD40.45071030
130BMPR1B0.44639389
131NEK60.44580946
132MAP2K10.44308858
133TTN0.43625627
134EPHA30.43558014
135BRAF0.42369367
136EGFR0.41126909
137CDK190.39190090
138CAMK2G0.38357266
139FGR0.37800321
140CDK11A0.37315596
141MAP3K10.37165200
142DYRK1B0.36289277
143MKNK20.35638369
144MOS0.35560046
145PRKG10.35203130
146ARAF0.34339209
147BMPR20.33260183
148CSNK1A1L0.32943801
149KSR20.32268966
150RPS6KA30.31541780
151MUSK0.31450084
152MAP3K50.31083239

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.60691866
2Synaptic vesicle cycle_Homo sapiens_hsa047213.15884942
3Selenocompound metabolism_Homo sapiens_hsa004502.43222454
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.35611418
5GABAergic synapse_Homo sapiens_hsa047272.31649324
6Circadian entrainment_Homo sapiens_hsa047132.29998986
7Glutamatergic synapse_Homo sapiens_hsa047242.14921204
8Morphine addiction_Homo sapiens_hsa050322.09482830
9Olfactory transduction_Homo sapiens_hsa047402.00914764
10Insulin secretion_Homo sapiens_hsa049111.84399338
11Serotonergic synapse_Homo sapiens_hsa047261.83862797
12Dopaminergic synapse_Homo sapiens_hsa047281.83656372
13Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.81391412
14Taste transduction_Homo sapiens_hsa047421.77883804
15Glycosaminoglycan degradation_Homo sapiens_hsa005311.73344093
16Axon guidance_Homo sapiens_hsa043601.72993322
17Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.71820258
18Cholinergic synapse_Homo sapiens_hsa047251.71631694
19Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.70559780
20Alcoholism_Homo sapiens_hsa050341.65428869
21Salivary secretion_Homo sapiens_hsa049701.59555430
22Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.52373831
23Non-homologous end-joining_Homo sapiens_hsa034501.49587571
24Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.49451765
25Long-term potentiation_Homo sapiens_hsa047201.49321044
26Focal adhesion_Homo sapiens_hsa045101.47880694
27Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.45225594
28Long-term depression_Homo sapiens_hsa047301.45101713
29Proteoglycans in cancer_Homo sapiens_hsa052051.42611514
30Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.40678541
31Amphetamine addiction_Homo sapiens_hsa050311.37665825
32Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.33901610
33ECM-receptor interaction_Homo sapiens_hsa045121.33645119
34Phototransduction_Homo sapiens_hsa047441.31592018
35Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.31289243
36Collecting duct acid secretion_Homo sapiens_hsa049661.29811580
37Calcium signaling pathway_Homo sapiens_hsa040201.27579468
38ErbB signaling pathway_Homo sapiens_hsa040121.26679014
39MicroRNAs in cancer_Homo sapiens_hsa052061.26222447
40Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.25319865
41Gap junction_Homo sapiens_hsa045401.25236703
42Type II diabetes mellitus_Homo sapiens_hsa049301.25138775
43Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.23803513
44GnRH signaling pathway_Homo sapiens_hsa049121.22127111
45Aldosterone synthesis and secretion_Homo sapiens_hsa049251.19448865
46Oxytocin signaling pathway_Homo sapiens_hsa049211.19314002
47Systemic lupus erythematosus_Homo sapiens_hsa053221.19167888
48Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.16997742
49Regulation of actin cytoskeleton_Homo sapiens_hsa048101.14269534
50Cocaine addiction_Homo sapiens_hsa050301.12587381
51Bladder cancer_Homo sapiens_hsa052191.11994706
52TGF-beta signaling pathway_Homo sapiens_hsa043501.11986883
53Adherens junction_Homo sapiens_hsa045201.11870874
54Renin secretion_Homo sapiens_hsa049241.11801705
55Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.11272091
56Phosphatidylinositol signaling system_Homo sapiens_hsa040701.10902699
57Glioma_Homo sapiens_hsa052141.05395784
58Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.04316439
59Small cell lung cancer_Homo sapiens_hsa052221.03885038
60cAMP signaling pathway_Homo sapiens_hsa040241.02055936
61p53 signaling pathway_Homo sapiens_hsa041151.00482659
62Sphingolipid metabolism_Homo sapiens_hsa006001.00374807
63Dorso-ventral axis formation_Homo sapiens_hsa043200.99309825
64Neurotrophin signaling pathway_Homo sapiens_hsa047220.98375110
65Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.95717069
66SNARE interactions in vesicular transport_Homo sapiens_hsa041300.95599383
67Melanogenesis_Homo sapiens_hsa049160.94466579
68Platelet activation_Homo sapiens_hsa046110.94051066
69Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.92516935
70Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.90832165
71Phagosome_Homo sapiens_hsa041450.89616278
72Gastric acid secretion_Homo sapiens_hsa049710.89579370
73Viral carcinogenesis_Homo sapiens_hsa052030.89394488
74Choline metabolism in cancer_Homo sapiens_hsa052310.87578780
75Hedgehog signaling pathway_Homo sapiens_hsa043400.87452968
76Amoebiasis_Homo sapiens_hsa051460.85773926
77AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.83857893
78MAPK signaling pathway_Homo sapiens_hsa040100.83246049
79Hepatitis B_Homo sapiens_hsa051610.82524540
80Fanconi anemia pathway_Homo sapiens_hsa034600.81725115
81PI3K-Akt signaling pathway_Homo sapiens_hsa041510.77412622
82Endometrial cancer_Homo sapiens_hsa052130.77313097
83Circadian rhythm_Homo sapiens_hsa047100.77299523
84Melanoma_Homo sapiens_hsa052180.76416549
85Wnt signaling pathway_Homo sapiens_hsa043100.75777346
86Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.75647905
87Steroid biosynthesis_Homo sapiens_hsa001000.75619563
88Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.75122128
89Ether lipid metabolism_Homo sapiens_hsa005650.75053456
90Vibrio cholerae infection_Homo sapiens_hsa051100.74704692
91Rheumatoid arthritis_Homo sapiens_hsa053230.73260662
92Phospholipase D signaling pathway_Homo sapiens_hsa040720.72952695
93Chronic myeloid leukemia_Homo sapiens_hsa052200.72542790
94Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.72531761
95Ras signaling pathway_Homo sapiens_hsa040140.71874471
96Sphingolipid signaling pathway_Homo sapiens_hsa040710.71590182
97TNF signaling pathway_Homo sapiens_hsa046680.70484568
98Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.70445276
99Lysine degradation_Homo sapiens_hsa003100.70372120
100Prolactin signaling pathway_Homo sapiens_hsa049170.69317537
101Pancreatic cancer_Homo sapiens_hsa052120.69237960
102Non-small cell lung cancer_Homo sapiens_hsa052230.69183179
103Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.69090103
104Renal cell carcinoma_Homo sapiens_hsa052110.68875883
105Colorectal cancer_Homo sapiens_hsa052100.68358491
106Oocyte meiosis_Homo sapiens_hsa041140.67621481
107Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.67468670
108Estrogen signaling pathway_Homo sapiens_hsa049150.67035169
109Longevity regulating pathway - mammal_Homo sapiens_hsa042110.64366279
110Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.64295000
111Dilated cardiomyopathy_Homo sapiens_hsa054140.60416644
112cGMP-PKG signaling pathway_Homo sapiens_hsa040220.60150886
113Type I diabetes mellitus_Homo sapiens_hsa049400.60044141
114Endocytosis_Homo sapiens_hsa041440.59757519
115Salmonella infection_Homo sapiens_hsa051320.58907808
116Rap1 signaling pathway_Homo sapiens_hsa040150.58691983
117Transcriptional misregulation in cancer_Homo sapiens_hsa052020.57098164
118RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.56485991
119Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.56413730
120Vascular smooth muscle contraction_Homo sapiens_hsa042700.56002275
121Prostate cancer_Homo sapiens_hsa052150.55766541
122Basal cell carcinoma_Homo sapiens_hsa052170.55690631
123Toxoplasmosis_Homo sapiens_hsa051450.53880328
124Lysosome_Homo sapiens_hsa041420.53617056
125Hippo signaling pathway_Homo sapiens_hsa043900.52499593
126VEGF signaling pathway_Homo sapiens_hsa043700.52489132
127Toll-like receptor signaling pathway_Homo sapiens_hsa046200.52122996
128Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51043969
129Pancreatic secretion_Homo sapiens_hsa049720.50131133
130Mineral absorption_Homo sapiens_hsa049780.49170106
131mTOR signaling pathway_Homo sapiens_hsa041500.48313964
132Tuberculosis_Homo sapiens_hsa051520.46826659
133Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.46575187
134Inositol phosphate metabolism_Homo sapiens_hsa005620.45879720
135Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.44047161
136Shigellosis_Homo sapiens_hsa051310.43660838
137Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.42469526
138African trypanosomiasis_Homo sapiens_hsa051430.42018715
139Carbohydrate digestion and absorption_Homo sapiens_hsa049730.41870391
140Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.40971711
141Regulation of autophagy_Homo sapiens_hsa041400.39646116
142Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.38624924

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