TCP11L2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.20977437
2microglial cell activation (GO:0001774)4.93845928
3positive regulation by symbiont of host defense response (GO:0052509)4.83981799
4modulation by symbiont of host defense response (GO:0052031)4.83981799
5modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.83981799
6modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.83981799
7positive regulation by organism of defense response of other organism involved in symbiotic interact4.83981799
8modulation by symbiont of host immune response (GO:0052553)4.83981799
9detection of molecule of bacterial origin (GO:0032490)4.67950665
10regulation of relaxation of muscle (GO:1901077)4.49298310
11macrophage activation involved in immune response (GO:0002281)4.23851806
12hepatocyte apoptotic process (GO:0097284)4.23407082
13regulation of gamma-delta T cell differentiation (GO:0045586)4.11365250
14positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.08816506
15regulation of gamma-delta T cell activation (GO:0046643)3.99325259
16regulation of interferon-beta biosynthetic process (GO:0045357)3.97790638
17macrophage activation (GO:0042116)3.94140904
18interferon-gamma production (GO:0032609)3.94064052
19regulation of B cell receptor signaling pathway (GO:0050855)3.83127989
20phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.82988195
21negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.81205456
22detection of external biotic stimulus (GO:0098581)3.72310141
23neutrophil mediated immunity (GO:0002446)3.66702411
24positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.63430385
25antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.62839705
26antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.62839705
27negative regulation of lymphocyte mediated immunity (GO:0002707)3.58013592
28negative regulation of T cell mediated immunity (GO:0002710)3.56186726
29leukocyte aggregation (GO:0070486)3.51234124
30response to interleukin-15 (GO:0070672)3.44644472
31regulation of necroptotic process (GO:0060544)3.43244253
32negative regulation of cell killing (GO:0031342)3.43197005
33negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.43197005
34response to host immune response (GO:0052572)3.42388919
35response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.42388919
36myeloid leukocyte mediated immunity (GO:0002444)3.38886204
37tolerance induction (GO:0002507)3.37821330
38regulation of interleukin-12 biosynthetic process (GO:0045075)3.35372604
39positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.35277434
40positive thymic T cell selection (GO:0045059)3.33608185
41cellular response to interleukin-15 (GO:0071350)3.32787250
42antigen processing and presentation of endogenous antigen (GO:0019883)3.30664610
43negative T cell selection (GO:0043383)3.26456113
44positive T cell selection (GO:0043368)3.25366862
45negative regulation of B cell proliferation (GO:0030889)3.23984302
46neutrophil activation involved in immune response (GO:0002283)3.23219454
47response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.22419071
48response to host (GO:0075136)3.22419071
49response to host defenses (GO:0052200)3.22419071
50detection of biotic stimulus (GO:0009595)3.20431897
51regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.14485012
52regulation of beta-amyloid formation (GO:1902003)3.06853148
53negative regulation of interleukin-12 production (GO:0032695)3.06554636
54negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.04750276
55negative thymic T cell selection (GO:0045060)3.00602365
56protein K11-linked deubiquitination (GO:0035871)3.00581571
57activated T cell proliferation (GO:0050798)2.98775352
58negative regulation of leukocyte mediated immunity (GO:0002704)2.98459770
59presynaptic membrane organization (GO:0097090)2.98354020
60myeloid cell activation involved in immune response (GO:0002275)2.97638349
61positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.95951292
62negative regulation of T-helper cell differentiation (GO:0045623)2.92437585
63negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.92437585
64regulation of platelet aggregation (GO:0090330)2.90709939
65negative regulation of humoral immune response (GO:0002921)2.89029156
66negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.86192944
67B cell receptor signaling pathway (GO:0050853)2.85104345
68negative regulation of immunoglobulin mediated immune response (GO:0002890)2.83676236
69negative regulation of B cell mediated immunity (GO:0002713)2.83676236
70cellular response to zinc ion (GO:0071294)2.83013023
71cellular response to ethanol (GO:0071361)2.81488185
72positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.80617640
73negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.78359486
74negative regulation of adaptive immune response (GO:0002820)2.77947333
75T cell migration (GO:0072678)2.76528600
76protoporphyrinogen IX metabolic process (GO:0046501)2.73075032
77T cell selection (GO:0045058)2.72895319
78thymic T cell selection (GO:0045061)2.71372903
79regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.70737146
80establishment of protein localization to Golgi (GO:0072600)2.70151964
81protein targeting to Golgi (GO:0000042)2.69558379
82positive regulation of interferon-alpha production (GO:0032727)2.69558246
83positive regulation of tolerance induction (GO:0002645)2.69272411
84regulation of actin filament-based movement (GO:1903115)2.67378804
85dendritic cell migration (GO:0036336)2.66693974
86respiratory burst (GO:0045730)2.65208619
87regulation of granulocyte differentiation (GO:0030852)2.64178093
88T cell receptor signaling pathway (GO:0050852)2.64035456
89retrograde transport, vesicle recycling within Golgi (GO:0000301)2.63960093
90response to peptidoglycan (GO:0032494)2.62985166
91production of molecular mediator involved in inflammatory response (GO:0002532)2.62775231
92regulation of amyloid precursor protein catabolic process (GO:1902991)2.62515978
93regulation of isotype switching to IgG isotypes (GO:0048302)2.61966312
94regulation of B cell differentiation (GO:0045577)2.61534366
95antigen receptor-mediated signaling pathway (GO:0050851)2.60731692
96histone H3-K4 trimethylation (GO:0080182)2.60485797
97positive regulation of interleukin-2 production (GO:0032743)2.58982884
98antigen processing and presentation via MHC class Ib (GO:0002475)2.58425049
99positive regulation of cellular amide metabolic process (GO:0034250)2.56555357
100regulation of T cell tolerance induction (GO:0002664)2.54281954
101regulation of cell communication by electrical coupling (GO:0010649)2.53928221
102regulation of cardiac muscle cell contraction (GO:0086004)2.53451228
103mast cell activation (GO:0045576)2.51043730
104creatine metabolic process (GO:0006600)2.49604264
105G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.48679382
106regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.47044502
107phagocytosis, recognition (GO:0006910)2.45869271
108positive regulation of B cell differentiation (GO:0045579)2.45748435
109positive regulation of granulocyte differentiation (GO:0030854)2.44232854
110regulation of regulatory T cell differentiation (GO:0045589)2.42737988
111detection of bacterium (GO:0016045)2.41203654
112negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.40381061
113cellular response to epinephrine stimulus (GO:0071872)2.40339188
114negative regulation of complement activation (GO:0045916)2.39891786
115detection of other organism (GO:0098543)2.38754144
116protoporphyrinogen IX biosynthetic process (GO:0006782)2.37773684
117regulation of tolerance induction (GO:0002643)2.37473484
118megakaryocyte development (GO:0035855)2.37322908
119antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.36859536
120membrane raft organization (GO:0031579)2.33674311
121regulation of alpha-beta T cell proliferation (GO:0046640)2.31223701
122presynaptic membrane assembly (GO:0097105)2.31066468
123histone H3-K36 demethylation (GO:0070544)2.29302690
124neutrophil activation (GO:0042119)2.28567620
125response to epinephrine (GO:0071871)2.27749110
126response to muramyl dipeptide (GO:0032495)2.27318222
127negative regulation of erythrocyte differentiation (GO:0045647)2.24559841
128T cell costimulation (GO:0031295)2.21430360
129regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.21132328
130regulation of natural killer cell mediated immunity (GO:0002715)2.21132328
131response to type I interferon (GO:0034340)2.20012087
132lymphocyte costimulation (GO:0031294)2.19788501
133oxygen transport (GO:0015671)2.19264652
134positive regulation of natural killer cell mediated immunity (GO:0002717)2.19259439
135positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.19259439
136regulation of T cell receptor signaling pathway (GO:0050856)2.18843880
137negative regulation of cAMP-mediated signaling (GO:0043951)2.18639987
138cellular extravasation (GO:0045123)2.17720431
139negative regulation of nitric-oxide synthase activity (GO:0051001)2.17018715
140cellular response to type I interferon (GO:0071357)2.15811574
141type I interferon signaling pathway (GO:0060337)2.15811574
142negative regulation of glycoprotein biosynthetic process (GO:0010561)2.14501406
143regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.13413035
144leukocyte homeostasis (GO:0001776)2.12477082
145negative regulation of T cell apoptotic process (GO:0070233)2.11859246
146regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.10957676
147definitive hemopoiesis (GO:0060216)2.10935515
148leukocyte cell-cell adhesion (GO:0007159)2.10275282
149T-helper cell differentiation (GO:0042093)2.09773859
150CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.09773859
151lymphocyte homeostasis (GO:0002260)2.04913044
152negative regulation of protein activation cascade (GO:2000258)2.04640474
153positive regulation of alpha-beta T cell proliferation (GO:0046641)2.04088903
154germinal center formation (GO:0002467)2.03863001
155negative regulation of monooxygenase activity (GO:0032769)2.02112609
156lymph node development (GO:0048535)2.01195720
157regulation of sarcomere organization (GO:0060297)2.00235806
158angiogenesis involved in wound healing (GO:0060055)2.00215848
159interferon-gamma-mediated signaling pathway (GO:0060333)2.00048412
160regulation of interleukin-2 production (GO:0032663)1.99768860

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.95873167
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.39533480
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.30277342
4RUNX_20019798_ChIP-Seq_JUKART_Human2.93951557
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.61390013
6IRF8_22096565_ChIP-ChIP_GC-B_Human2.58180636
7SCL_19346495_ChIP-Seq_HPC-7_Human2.55683845
8VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.38404333
9GATA1_22025678_ChIP-Seq_K562_Human2.37932809
10* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.32708518
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.30825103
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.29218928
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.11154117
14* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.96796177
15LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.87510143
16SMAD_19615063_ChIP-ChIP_OVARY_Human1.86995682
17RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.84091370
18IRF8_27001747_Chip-Seq_BMDM_Mouse1.82361732
19STAT4_19710469_ChIP-ChIP_TH1__Mouse1.80962841
20GATA2_21666600_ChIP-Seq_HMVEC_Human1.79065171
21IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.76650527
22NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.63399189
23THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.62989164
24AR_21572438_ChIP-Seq_LNCaP_Human1.61274149
25* GATA1_19941826_ChIP-Seq_K562_Human1.56710501
26GATA1_19941827_ChIP-Seq_MEL_Mouse1.56627727
27* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.56138164
28IRF8_21731497_ChIP-ChIP_J774_Mouse1.55994546
29* GATA2_19941826_ChIP-Seq_K562_Human1.55254997
30MYB_26560356_Chip-Seq_TH2_Human1.51071187
31SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.47853143
32FOXO3_23340844_ChIP-Seq_DLD1_Human1.47242481
33MYB_21317192_ChIP-Seq_ERMYB_Mouse1.47202210
34SPI1_23547873_ChIP-Seq_NB4_Human1.46890484
35* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.43988635
36LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.42563802
37STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.38487744
38GBX2_23144817_ChIP-Seq_PC3_Human1.36733547
39TP53_16413492_ChIP-PET_HCT116_Human1.33694598
40RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.31248306
41* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.26400401
42MAF_26560356_Chip-Seq_TH1_Human1.26117478
43GATA3_27048872_Chip-Seq_THYMUS_Human1.22321154
44DROSHA_22980978_ChIP-Seq_HELA_Human1.22236726
45E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.16386740
46SPI1_23127762_ChIP-Seq_K562_Human1.15878044
47SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14278996
48FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.13724915
49PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13672764
50* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.12714544
51KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.12205223
52TAF15_26573619_Chip-Seq_HEK293_Human1.11049069
53TCF7_22412390_ChIP-Seq_EML_Mouse1.10177374
54EP300_21415370_ChIP-Seq_HL-1_Mouse1.08958191
55GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08367608
56MYB_26560356_Chip-Seq_TH1_Human1.07163448
57NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.07007700
58GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.06688062
59VDR_24787735_ChIP-Seq_THP-1_Human1.06668054
60AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.05544858
61ESR1_20079471_ChIP-ChIP_T-47D_Human1.03091662
62GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02135055
63FLI1_27457419_Chip-Seq_LIVER_Mouse1.01936238
64GATA3_26560356_Chip-Seq_TH2_Human1.00498857
65NOTCH1_21737748_ChIP-Seq_TLL_Human0.99676464
66CDX2_19796622_ChIP-Seq_MESCs_Mouse0.99138356
67KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.98864846
68GATA1_19941827_ChIP-Seq_MEL86_Mouse0.97559121
69EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.96932169
70EGR1_23403033_ChIP-Seq_LIVER_Mouse0.96629047
71* RUNX1_22412390_ChIP-Seq_EML_Mouse0.96067988
72UTX_26944678_Chip-Seq_JUKART_Human0.95915024
73* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.95189531
74STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.93479370
75BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.93276305
76ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.93194138
77* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.92484756
78RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91441883
79ARNT_22903824_ChIP-Seq_MCF-7_Human0.90178966
80CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.89284476
81PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.88880138
82TBX20_22080862_ChIP-Seq_HEART_Mouse0.88711287
83TBX20_22328084_ChIP-Seq_HEART_Mouse0.88711287
84TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87229138
85FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.87194746
86PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.86472414
87TP63_23658742_ChIP-Seq_EP156T_Human0.85653945
88* FLI1_21867929_ChIP-Seq_TH2_Mouse0.85501980
89LXR_22158963_ChIP-Seq_LIVER_Mouse0.84083245
90* PU_27001747_Chip-Seq_BMDM_Mouse0.83652668
91OCT4_21477851_ChIP-Seq_ESCs_Mouse0.83355679
92KDM2B_26808549_Chip-Seq_SUP-B15_Human0.82915968
93RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.82891811
94ER_23166858_ChIP-Seq_MCF-7_Human0.82727505
95EGR1_19032775_ChIP-ChIP_M12_Human0.81987917
96GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81878912
97ZFP57_27257070_Chip-Seq_ESCs_Mouse0.81851802
98PIAS1_25552417_ChIP-Seq_VCAP_Human0.81848431
99* POU3F2_20337985_ChIP-ChIP_501MEL_Human0.81219052
100PCGF2_27294783_Chip-Seq_NPCs_Mouse0.80371056
101FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.80010930
102NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.79789712
103NRF2_20460467_ChIP-Seq_MEFs_Mouse0.79235791
104NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.79235791
105ZNF217_24962896_ChIP-Seq_MCF-7_Human0.79200907
106CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.79107612
107SALL1_21062744_ChIP-ChIP_HESCs_Human0.78429537
108AHR_22903824_ChIP-Seq_MCF-7_Human0.77944621
109SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.77776643
110ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.77314565
111STAT3_23295773_ChIP-Seq_U87_Human0.77263881
112* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.76989513
113* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.76834969
114FOXA2_19822575_ChIP-Seq_HepG2_Human0.75680037
115GATA3_26560356_Chip-Seq_TH1_Human0.75261085
116SUZ12_27294783_Chip-Seq_NPCs_Mouse0.74912990
117PCGF2_27294783_Chip-Seq_ESCs_Mouse0.74780868
118GATA2_22383799_ChIP-Seq_G1ME_Mouse0.73784873
119CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.73448521
120OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.73363360
121PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.73345750
122* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.73328051
123SMAD4_21799915_ChIP-Seq_A2780_Human0.73158046
124CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.72470530
125EZH2_27294783_Chip-Seq_NPCs_Mouse0.72233816
126RXR_22158963_ChIP-Seq_LIVER_Mouse0.72017254
127PPAR_26484153_Chip-Seq_NCI-H1993_Human0.71856875
128SMRT_27268052_Chip-Seq_Bcells_Human0.71768002
129PRDM14_20953172_ChIP-Seq_ESCs_Human0.71731485
130TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.70921111
131FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.70343708
132PPARA_22158963_ChIP-Seq_LIVER_Mouse0.69519028
133VDR_24763502_ChIP-Seq_THP-1_Human0.68744107

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.12211668
2MP0005671_abnormal_response_to3.11465255
3MP0004147_increased_porphyrin_level3.08917269
4MP0003724_increased_susceptibility_to2.74693895
5MP0003656_abnormal_erythrocyte_physiolo2.73862426
6MP0002837_dystrophic_cardiac_calcinosis2.58210597
7MP0001790_abnormal_immune_system2.49562009
8MP0005387_immune_system_phenotype2.49562009
9MP0003303_peritoneal_inflammation2.45802503
10MP0001835_abnormal_antigen_presentation2.31903602
11MP0003763_abnormal_thymus_physiology2.31459901
12MP0000685_abnormal_immune_system2.30294347
13MP0001800_abnormal_humoral_immune2.29044809
14MP0009785_altered_susceptibility_to2.25351400
15MP0005451_abnormal_body_composition2.22691992
16MP0003646_muscle_fatigue2.20334637
17MP0003172_abnormal_lysosome_physiology2.14642636
18MP0002723_abnormal_immune_serum2.01931750
19MP0002419_abnormal_innate_immunity1.97605038
20MP0005000_abnormal_immune_tolerance1.94312409
21MP0002420_abnormal_adaptive_immunity1.92915267
22MP0002452_abnormal_antigen_presenting1.91870469
23MP0001819_abnormal_immune_cell1.87582105
24MP0002933_joint_inflammation1.86775470
25MP0002148_abnormal_hypersensitivity_rea1.86661835
26MP0005025_abnormal_response_to1.84628636
27MP0003787_abnormal_imprinting1.80866684
28MP0005464_abnormal_platelet_physiology1.72061820
29MP0003436_decreased_susceptibility_to1.70750239
30MP0004215_abnormal_myocardial_fiber1.69014207
31MP0004084_abnormal_cardiac_muscle1.68548910
32MP0004130_abnormal_muscle_cell1.67844501
33MP0000015_abnormal_ear_pigmentation1.67141722
34MP0004036_abnormal_muscle_relaxation1.65781050
35MP0000343_altered_response_to1.62886292
36MP0010368_abnormal_lymphatic_system1.61235654
37MP0004484_altered_response_of1.60706135
38MP0008057_abnormal_DNA_replication1.57596062
39MP0000749_muscle_degeneration1.56586812
40MP0003828_pulmonary_edema1.55449940
41MP0000465_gastrointestinal_hemorrhage1.55210809
42MP0002009_preneoplasia1.51784928
43MP0003221_abnormal_cardiomyocyte_apopto1.51276156
44MP0001853_heart_inflammation1.49087353
45MP0000920_abnormal_myelination1.47434024
46MP0000716_abnormal_immune_system1.46327997
47MP0002398_abnormal_bone_marrow1.45278437
48MP0001873_stomach_inflammation1.44419352
49MP0003950_abnormal_plasma_membrane1.40128420
50MP0008260_abnormal_autophagy1.39843905
51MP0002405_respiratory_system_inflammati1.39581950
52MP0005174_abnormal_tail_pigmentation1.37458964
53MP0005310_abnormal_salivary_gland1.37331922
54MP0002006_tumorigenesis1.36629096
55MP0004510_myositis1.36597876
56MP0009764_decreased_sensitivity_to1.31842543
57MP0000689_abnormal_spleen_morphology1.31359909
58MP0003191_abnormal_cellular_cholesterol1.31008164
59MP0008775_abnormal_heart_ventricle1.30729982
60MP0004808_abnormal_hematopoietic_stem1.30165764
61MP0001545_abnormal_hematopoietic_system1.29782632
62MP0005397_hematopoietic_system_phenotyp1.29782632
63MP0001845_abnormal_inflammatory_respons1.26737548
64MP0006082_CNS_inflammation1.26019777
65MP0001533_abnormal_skeleton_physiology1.23453796
66MP0004947_skin_inflammation1.22738591
67MP0002166_altered_tumor_susceptibility1.21887453
68MP0003690_abnormal_glial_cell1.19785381
69MP0002396_abnormal_hematopoietic_system1.19441512
70MP0003300_gastrointestinal_ulcer1.17934207
71MP0010155_abnormal_intestine_physiology1.17483285
72MP0002429_abnormal_blood_cell1.16313461
73MP0002722_abnormal_immune_system1.16143443
74MP0006054_spinal_hemorrhage1.14154140
75MP0003279_aneurysm1.12209190
76MP0001879_abnormal_lymphatic_vessel1.09744477
77MP0002972_abnormal_cardiac_muscle1.09722625
78MP0008469_abnormal_protein_level1.09186781
79MP0000751_myopathy1.06414636
80MP0008004_abnormal_stomach_pH1.04512422
81MP0005058_abnormal_lysosome_morphology1.04389955
82MP0002132_abnormal_respiratory_system1.04074580
83MP0000858_altered_metastatic_potential1.03454882
84MP0005330_cardiomyopathy1.02631254
85MP0003091_abnormal_cell_migration1.02577833
86MP0001851_eye_inflammation1.01627519
87MP0004381_abnormal_hair_follicle0.98437212
88MP0002998_abnormal_bone_remodeling0.97345026
89MP0009333_abnormal_splenocyte_physiolog0.95062116
90MP0001502_abnormal_circadian_rhythm0.94263439
91MP0003866_abnormal_defecation0.91784074
92MP0005083_abnormal_biliary_tract0.91372184
93MP0001542_abnormal_bone_strength0.89384076
94MP0008877_abnormal_DNA_methylation0.88431533
95MP0003045_fibrosis0.88073951
96MP0000703_abnormal_thymus_morphology0.88008520
97MP0002332_abnormal_exercise_endurance0.87137967
98MP0000371_diluted_coat_color0.86530867
99MP0008874_decreased_physiological_sensi0.84908013
100MP0008569_lethality_at_weaning0.84523564
101MP0005620_abnormal_muscle_contractility0.84303539
102MP0009278_abnormal_bone_marrow0.83831286
103MP0004883_abnormal_blood_vessel0.82648300
104MP0005165_increased_susceptibility_to0.82316173
105MP0009763_increased_sensitivity_to0.81221640
106MP0005376_homeostasis/metabolism_phenot0.80558059
107MP0002138_abnormal_hepatobiliary_system0.79882644
108MP0000249_abnormal_blood_vessel0.79859956
109MP0001544_abnormal_cardiovascular_syste0.77998804
110MP0005385_cardiovascular_system_phenoty0.77998804
111MP0000604_amyloidosis0.77645633
112MP0005075_abnormal_melanosome_morpholog0.77028067
113MP0002735_abnormal_chemical_nociception0.76774470
114MP0003183_abnormal_peptide_metabolism0.75627260
115MP0008995_early_reproductive_senescence0.73594231
116MP0005388_respiratory_system_phenotype0.71567841
117MP0002133_abnormal_respiratory_system0.71567841
118MP0009765_abnormal_xenobiotic_induced0.71004351
119MP0005164_abnormal_response_to0.70933022
120MP0004087_abnormal_muscle_fiber0.70753192
121MP0004085_abnormal_heartbeat0.70721842
122MP0003075_altered_response_to0.70679018
123MP0005595_abnormal_vascular_smooth0.70638145
124MP0005584_abnormal_enzyme/coenzyme_acti0.69995171
125MP0000230_abnormal_systemic_arterial0.69030941
126MP0005266_abnormal_metabolism0.68837569
127MP0001958_emphysema0.67416111
128MP0009115_abnormal_fat_cell0.63022950
129MP0000427_abnormal_hair_cycle0.61971478
130MP0005409_darkened_coat_color0.58359266
131MP0003453_abnormal_keratinocyte_physiol0.58274775
132MP0002277_abnormal_respiratory_mucosa0.58011094
133MP0001915_intracranial_hemorrhage0.57311539
134MP0005621_abnormal_cell_physiology0.54831397

Predicted human phenotypes

RankGene SetZ-score
1Parkinsonism with favorable response to dopaminergic medication (HP:0002548)5.14456414
2Gastrointestinal infarctions (HP:0005244)4.12441897
3Exercise-induced myalgia (HP:0003738)3.50617517
4Agammaglobulinemia (HP:0004432)3.42023655
5Hypochromic microcytic anemia (HP:0004840)3.41655785
6Stomatitis (HP:0010280)3.33791177
7Gingivitis (HP:0000230)3.20108385
8Recurrent sinusitis (HP:0011108)3.15242435
9Myositis (HP:0100614)3.06884539
10Calf muscle hypertrophy (HP:0008981)3.06069983
11Subacute progressive viral hepatitis (HP:0006572)3.03909338
12Leukocytosis (HP:0001974)3.03214095
13Slow saccadic eye movements (HP:0000514)3.01151165
14Elevated erythrocyte sedimentation rate (HP:0003565)2.95516968
15Chest pain (HP:0100749)2.95209161
16Recurrent bronchitis (HP:0002837)2.94173579
17T lymphocytopenia (HP:0005403)2.91586322
18Spontaneous hematomas (HP:0007420)2.91295722
19Keratoconjunctivitis (HP:0001096)2.91213194
20Gastrointestinal stroma tumor (HP:0100723)2.90190338
21Panhypogammaglobulinemia (HP:0003139)2.90189066
22Recurrent fungal infections (HP:0002841)2.89861624
23Recurrent cutaneous fungal infections (HP:0011370)2.88485707
24Chronic mucocutaneous candidiasis (HP:0002728)2.88485707
25Muscle hypertrophy of the lower extremities (HP:0008968)2.85775561
26Peritonitis (HP:0002586)2.83937140
27Abnormality of T cell number (HP:0011839)2.82062284
28Chronic otitis media (HP:0000389)2.80160214
29Eczematoid dermatitis (HP:0000976)2.79720769
30Papillary thyroid carcinoma (HP:0002895)2.78519586
31Urticaria (HP:0001025)2.75231260
32Abnormal delayed hypersensitivity skin test (HP:0002963)2.72908604
33Abnormality of the fingertips (HP:0001211)2.72740475
34Optic neuritis (HP:0100653)2.72241340
35Retrobulbar optic neuritis (HP:0100654)2.72241340
36Hypochromic anemia (HP:0001931)2.72139408
37Inflammation of the large intestine (HP:0002037)2.69103012
38Stomach cancer (HP:0012126)2.66916430
39Eosinophilia (HP:0001880)2.66846237
40Postural instability (HP:0002172)2.66789959
41Colitis (HP:0002583)2.65253619
42Ventricular tachycardia (HP:0004756)2.65032686
43IgM deficiency (HP:0002850)2.62085532
44Mediastinal lymphadenopathy (HP:0100721)2.61204750
45Orchitis (HP:0100796)2.58227035
46EMG: myopathic abnormalities (HP:0003458)2.57102702
47Recurrent abscess formation (HP:0002722)2.54942544
48Autoimmune hemolytic anemia (HP:0001890)2.54595943
49Hematochezia (HP:0002573)2.54327594
50Chronic sinusitis (HP:0011109)2.51445199
51Meningitis (HP:0001287)2.49320050
52Abnormality of the nasal mucosa (HP:0000433)2.47723905
53Gastrointestinal inflammation (HP:0004386)2.46384147
54Thyroid-stimulating hormone excess (HP:0002925)2.44266570
55Renal cortical cysts (HP:0000803)2.42875633
56Chronic diarrhea (HP:0002028)2.40733310
57Abnormality of fatty-acid metabolism (HP:0004359)2.39962260
58Microcytic anemia (HP:0001935)2.39456869
59Increased IgE level (HP:0003212)2.39094370
60Viral hepatitis (HP:0006562)2.39013674
61Epistaxis (HP:0000421)2.35286770
62Purpura (HP:0000979)2.34744688
63Granulocytopenia (HP:0001913)2.33466608
64Obstructive lung disease (HP:0006536)2.33404145
65Chronic obstructive pulmonary disease (HP:0006510)2.33404145
66Atrial fibrillation (HP:0005110)2.33208501
67Hemoptysis (HP:0002105)2.31740074
68Prolonged bleeding time (HP:0003010)2.30628425
69Abnormality of the calf musculature (HP:0001430)2.29029828
70Recurrent viral infections (HP:0004429)2.27418326
71Easy fatigability (HP:0003388)2.25842940
72Neoplasm of the tracheobronchial system (HP:0100552)2.25038950
73Asymmetric septal hypertrophy (HP:0001670)2.24673533
74Abnormal hair whorl (HP:0010721)2.24351104
75Vasculitis (HP:0002633)2.23727387
76Anorexia (HP:0002039)2.23617873
77Nasal polyposis (HP:0100582)2.23096394
78Pulmonary infiltrates (HP:0002113)2.22793734
79Cellulitis (HP:0100658)2.19885090
80Exercise-induced muscle cramps (HP:0003710)2.19712650
81Recurrent skin infections (HP:0001581)2.18003925
82Muscle fiber splitting (HP:0003555)2.16896537
83Lipoatrophy (HP:0100578)2.16312044
84Pustule (HP:0200039)2.14123154
85Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.13732774
86Pulmonary embolism (HP:0002204)2.13121940
87Episodic fever (HP:0001954)2.12412572
88Papilloma (HP:0012740)2.12071519
89Verrucae (HP:0200043)2.12071519
90Difficulty running (HP:0009046)2.10608847
91Autoimmune thrombocytopenia (HP:0001973)2.09102245
92Petechiae (HP:0000967)2.08628899
93Gingival bleeding (HP:0000225)2.07949587
94Poikilocytosis (HP:0004447)2.07204614
95White forelock (HP:0002211)2.07088252
96Gangrene (HP:0100758)2.05831689
97Osteomyelitis (HP:0002754)2.05271891
98Sudden death (HP:0001699)2.03631373
99Primary atrial arrhythmia (HP:0001692)2.03490373
100Bronchitis (HP:0012387)2.03327676
101Dilated cardiomyopathy (HP:0001644)2.02543686
102Abnormality of the vasculature of the conjunctiva (HP:0008054)2.02412348
103Periodontitis (HP:0000704)2.01166930
104Nemaline bodies (HP:0003798)2.00440553
105Abnormality of T cells (HP:0002843)1.99684110
106Abnormality of T cell physiology (HP:0011840)1.97671308
107Supraventricular tachycardia (HP:0004755)1.97390541
108Central scotoma (HP:0000603)1.96983457
109Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.96803791
110Encephalitis (HP:0002383)1.96524309
111Patchy hypopigmentation of hair (HP:0011365)1.96362708
112Abnormality of macrophages (HP:0004311)1.96311640
113Onycholysis (HP:0001806)1.96144391
114Myoglobinuria (HP:0002913)1.95032822
115Keratoconjunctivitis sicca (HP:0001097)1.94801610
116Recurrent gram-negative bacterial infections (HP:0005420)1.94119316
117Conjunctival telangiectasia (HP:0000524)1.93150516
118Weak cry (HP:0001612)1.93120123
119Muscle fiber inclusion bodies (HP:0100299)1.92836284
120Hyperkalemia (HP:0002153)1.92638518
121Bulbar palsy (HP:0001283)1.92035937
122Arterial thrombosis (HP:0004420)1.90704590
123Mitral stenosis (HP:0001718)1.89967030
124Hypoplasia of the thymus (HP:0000778)1.89606130
125Acute hepatic failure (HP:0006554)1.89476431
126Supraventricular arrhythmia (HP:0005115)1.88491458
127Alveolar cell carcinoma (HP:0006519)1.87801701
128Visual hallucinations (HP:0002367)1.86640334
129Abnormality of the endocardium (HP:0004306)1.86621255
130Recurrent bacterial skin infections (HP:0005406)1.85711149
131Hepatosplenomegaly (HP:0001433)1.85100241
132Congenital stationary night blindness (HP:0007642)1.84445011
133Hyporeflexia of lower limbs (HP:0002600)1.84326523
134IgG deficiency (HP:0004315)1.83569061
135Subaortic stenosis (HP:0001682)1.82475164
136Abnormality of the left ventricular outflow tract (HP:0011103)1.82475164
137Cholelithiasis (HP:0001081)1.82121229
138Abnormality of the peritoneum (HP:0002585)1.80393081
139Abnormality of the heme biosynthetic pathway (HP:0010472)1.78737703
140Interstitial pulmonary disease (HP:0006530)1.78690002
141Cerebral palsy (HP:0100021)1.78647488
142Lymphopenia (HP:0001888)1.78185809
143Retinal atrophy (HP:0001105)1.78126757
144Toxemia of pregnancy (HP:0100603)1.78016031
145Abnormality of eosinophils (HP:0001879)1.76746440
146Joint swelling (HP:0001386)1.75489555
147Thyroiditis (HP:0100646)1.75489054
148Thyroid carcinoma (HP:0002890)1.75158981
149Genetic anticipation (HP:0003743)1.73808604
150Thrombophlebitis (HP:0004418)1.71936691
151Vertigo (HP:0002321)1.71157486
152Fatigue (HP:0012378)1.71144071
153Ocular albinism (HP:0001107)1.71027864
154Abnormality of the pleura (HP:0002103)1.69595508
155Glucose intolerance (HP:0000833)1.69334770

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK43.37743342
2TXK3.29427550
3MAP4K13.04816204
4TGFBR22.74709198
5ITK2.20808892
6FRK2.14744681
7TNIK2.05573937
8EPHB12.05199213
9IKBKE1.99152135
10IRAK41.89627913
11WNK11.88807409
12TEC1.87434051
13NLK1.83896562
14TRPM71.82455344
15GRK71.82432498
16FGR1.82266434
17ZAP701.72118717
18FES1.70742947
19MYLK1.69193660
20MAP3K141.64764670
21TTN1.64383891
22MAP3K21.64300696
23TIE11.63536250
24MAP2K31.60462908
25PTK2B1.59857317
26BMPR21.58493094
27TBK11.57073301
28BTK1.53436010
29MUSK1.50375826
30JAK11.46848603
31MAP3K121.45549495
32IKBKB1.38436704
33EPHA31.36926349
34PRPF4B1.36694118
35TAOK11.36663457
36STK101.35235875
37TYK21.35026767
38PINK11.32290030
39GRK61.30956520
40MAPK121.30543775
41KIT1.29597794
42CSK1.29110798
43MARK21.28757176
44STK41.27754059
45MAP3K101.25937916
46YES11.25882977
47JAK31.25235593
48IRAK31.23533335
49FGFR41.22358651
50MST41.17914400
51MAP3K11.12289510
52GRK51.11732093
53STK241.07877671
54SYK1.07090625
55PRKCH1.06271509
56EEF2K1.06207166
57LCK1.06084190
58CAMKK21.02396695
59SGK21.01298228
60MAPK70.97671393
61MAP3K130.96496739
62AKT30.94680410
63HCK0.94680070
64MAP2K60.94408326
65HIPK20.94203355
66IRAK20.93353969
67INSRR0.92259057
68PKN10.91897408
69STK380.90848589
70SGK30.87905386
71MAP3K70.87601478
72PHKG20.86546977
73PHKG10.86546977
74CASK0.86111534
75PDK20.85829078
76PRKCQ0.85739411
77MAPKAPK30.83263360
78JAK20.82759715
79SGK4940.82731179
80SGK2230.82731179
81PIM10.78191038
82STK110.78029741
83CSF1R0.77856519
84LYN0.76817183
85PLK20.75338003
86MAPKAPK50.75267526
87IRAK10.74901399
88TNK20.74395297
89OBSCN0.74160016
90KDR0.72284804
91ERBB20.71257850
92SGK10.71021791
93SIK30.70638202
94LRRK20.70314183
95KSR20.70136024
96TAOK30.68721866
97FGFR30.68409897
98MAP3K50.67833814
99DYRK1A0.66843604
100GRK10.65754155
101FLT30.65237665
102MAP3K110.65042071
103CHUK0.63903645
104CDK120.61229332
105CAMK1D0.60735846
106DYRK1B0.59247656
107MARK30.58746251
108NEK60.57619216
109FGFR20.56363012
110BLK0.56182456
111PRKAA20.56144540
112PAK30.56077801
113RET0.54833191
114MATK0.54747142
115MAP2K40.54521668
116CDK30.54247404
117DMPK0.53213923
118PRKD10.53062030
119PRKD20.52258063
120CAMK40.52097223
121ERN10.51563295
122PKN20.50563471
123ROCK20.50468765
124NUAK10.50460001
125PDK10.50057315
126PDGFRB0.49643537
127MAP3K60.49139043
128KSR10.48914226
129CAMK10.48666342
130FYN0.48258690
131ADRBK20.47252825
132ACVR1B0.46998452
133MAP3K30.46362055
134PIK3CA0.44260432
135PIK3CG0.44178299
136MAPK150.44115483
137NEK90.43745763
138RAF10.42675897
139RPS6KA60.42240460
140MAPK40.41504304
141IGF1R0.41261135
142CLK10.39803845
143PRKCE0.39702664

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.48630337
2Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.60967154
3Non-small cell lung cancer_Homo sapiens_hsa052231.91263575
4Osteoclast differentiation_Homo sapiens_hsa043801.89069433
5Leishmaniasis_Homo sapiens_hsa051401.86551620
6T cell receptor signaling pathway_Homo sapiens_hsa046601.82344438
7Sulfur metabolism_Homo sapiens_hsa009201.82037060
8Fatty acid elongation_Homo sapiens_hsa000621.81638269
9B cell receptor signaling pathway_Homo sapiens_hsa046621.78992519
10Hematopoietic cell lineage_Homo sapiens_hsa046401.76992991
11Regulation of autophagy_Homo sapiens_hsa041401.76636315
12Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.75613441
13NF-kappa B signaling pathway_Homo sapiens_hsa040641.69542219
14Intestinal immune network for IgA production_Homo sapiens_hsa046721.69168195
15Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.68965705
16ABC transporters_Homo sapiens_hsa020101.68696756
17Measles_Homo sapiens_hsa051621.61131486
18Dorso-ventral axis formation_Homo sapiens_hsa043201.54870083
19Malaria_Homo sapiens_hsa051441.49766181
20Graft-versus-host disease_Homo sapiens_hsa053321.38398558
21RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.35575656
22Staphylococcus aureus infection_Homo sapiens_hsa051501.33780518
23Circadian rhythm_Homo sapiens_hsa047101.32118538
24Rheumatoid arthritis_Homo sapiens_hsa053231.31853636
25Fatty acid degradation_Homo sapiens_hsa000711.30416066
26Pancreatic cancer_Homo sapiens_hsa052121.27824812
27Prolactin signaling pathway_Homo sapiens_hsa049171.25728302
28Inositol phosphate metabolism_Homo sapiens_hsa005621.21610207
29Jak-STAT signaling pathway_Homo sapiens_hsa046301.21538138
30Endometrial cancer_Homo sapiens_hsa052131.21407726
31Renal cell carcinoma_Homo sapiens_hsa052111.19702969
32Toll-like receptor signaling pathway_Homo sapiens_hsa046201.19483197
33Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.19041231
34Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.17147479
35Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.15804642
36Chronic myeloid leukemia_Homo sapiens_hsa052201.15196674
37Leukocyte transendothelial migration_Homo sapiens_hsa046701.14676260
38mTOR signaling pathway_Homo sapiens_hsa041501.12435262
39Autoimmune thyroid disease_Homo sapiens_hsa053201.10960300
40Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.10678932
41Type I diabetes mellitus_Homo sapiens_hsa049401.07587453
42Dilated cardiomyopathy_Homo sapiens_hsa054141.06933731
43Chemokine signaling pathway_Homo sapiens_hsa040621.05254112
44Neurotrophin signaling pathway_Homo sapiens_hsa047221.04962610
45VEGF signaling pathway_Homo sapiens_hsa043701.04845286
46Platelet activation_Homo sapiens_hsa046111.03151506
47Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.03003060
48Propanoate metabolism_Homo sapiens_hsa006401.00529973
49Fatty acid metabolism_Homo sapiens_hsa012120.99685274
50Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.99451927
51Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.99304955
52Allograft rejection_Homo sapiens_hsa053300.97697588
53NOD-like receptor signaling pathway_Homo sapiens_hsa046210.96137224
54Apoptosis_Homo sapiens_hsa042100.95412272
55Toxoplasmosis_Homo sapiens_hsa051450.94984942
56Herpes simplex infection_Homo sapiens_hsa051680.94047322
57Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.93724640
58Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.93420640
59Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.93334085
60Other glycan degradation_Homo sapiens_hsa005110.93189158
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.89316296
62Choline metabolism in cancer_Homo sapiens_hsa052310.88958959
63Carbohydrate digestion and absorption_Homo sapiens_hsa049730.87101574
64Acute myeloid leukemia_Homo sapiens_hsa052210.85972300
65Longevity regulating pathway - mammal_Homo sapiens_hsa042110.85882588
66Tuberculosis_Homo sapiens_hsa051520.85775035
67Caffeine metabolism_Homo sapiens_hsa002320.84709064
68Antigen processing and presentation_Homo sapiens_hsa046120.83395545
69TNF signaling pathway_Homo sapiens_hsa046680.83035520
70SNARE interactions in vesicular transport_Homo sapiens_hsa041300.82783160
71Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.82724209
72Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.82487450
73Prostate cancer_Homo sapiens_hsa052150.79373794
74Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.78522933
75ErbB signaling pathway_Homo sapiens_hsa040120.77493130
76Asthma_Homo sapiens_hsa053100.77329319
77Complement and coagulation cascades_Homo sapiens_hsa046100.77001991
78GnRH signaling pathway_Homo sapiens_hsa049120.75891186
79Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.75855539
80Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.75221820
81Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.75099078
82Viral myocarditis_Homo sapiens_hsa054160.74411223
83Hepatitis C_Homo sapiens_hsa051600.74343769
84Glioma_Homo sapiens_hsa052140.73505970
85Adipocytokine signaling pathway_Homo sapiens_hsa049200.73314697
86Pertussis_Homo sapiens_hsa051330.73229310
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.72996006
88Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.71476673
89Type II diabetes mellitus_Homo sapiens_hsa049300.70640713
90Collecting duct acid secretion_Homo sapiens_hsa049660.70417736
91Insulin resistance_Homo sapiens_hsa049310.70333000
92Lysosome_Homo sapiens_hsa041420.69753933
93HIF-1 signaling pathway_Homo sapiens_hsa040660.69570903
94African trypanosomiasis_Homo sapiens_hsa051430.68755994
95Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.68748675
96Peroxisome_Homo sapiens_hsa041460.68185132
97Thyroid hormone signaling pathway_Homo sapiens_hsa049190.68001565
98Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.67667797
99Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.67262037
100Long-term potentiation_Homo sapiens_hsa047200.67012710
101Phospholipase D signaling pathway_Homo sapiens_hsa040720.64472713
102Notch signaling pathway_Homo sapiens_hsa043300.63447118
103Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.63421631
104Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.62594115
105Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.62379048
106Small cell lung cancer_Homo sapiens_hsa052220.61761459
107Renin secretion_Homo sapiens_hsa049240.60424013
108Morphine addiction_Homo sapiens_hsa050320.59508078
109Colorectal cancer_Homo sapiens_hsa052100.59494654
110Influenza A_Homo sapiens_hsa051640.59329171
111Glycerophospholipid metabolism_Homo sapiens_hsa005640.57661358
112Sphingolipid metabolism_Homo sapiens_hsa006000.57429657
113AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.55374761
114Transcriptional misregulation in cancer_Homo sapiens_hsa052020.55250023
115PPAR signaling pathway_Homo sapiens_hsa033200.54337023
116Cardiac muscle contraction_Homo sapiens_hsa042600.54179196
117Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.54080174
118Thyroid cancer_Homo sapiens_hsa052160.53123316
119Salmonella infection_Homo sapiens_hsa051320.52919495
120FoxO signaling pathway_Homo sapiens_hsa040680.52459367
121Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.52340372
122Ras signaling pathway_Homo sapiens_hsa040140.49592513
123Viral carcinogenesis_Homo sapiens_hsa052030.49263769
124cGMP-PKG signaling pathway_Homo sapiens_hsa040220.48575034
125Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48308205
126Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.47918679
127Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.47532148
128Histidine metabolism_Homo sapiens_hsa003400.47208612
129Insulin signaling pathway_Homo sapiens_hsa049100.46873257
130Amoebiasis_Homo sapiens_hsa051460.46296999
131MAPK signaling pathway_Homo sapiens_hsa040100.45312507
132Phosphatidylinositol signaling system_Homo sapiens_hsa040700.44642048
133Ether lipid metabolism_Homo sapiens_hsa005650.43092290
134cAMP signaling pathway_Homo sapiens_hsa040240.42978151
135Arachidonic acid metabolism_Homo sapiens_hsa005900.42853325
136Calcium signaling pathway_Homo sapiens_hsa040200.42585421
137Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.42142124
138Endocytosis_Homo sapiens_hsa041440.41866408
139Phagosome_Homo sapiens_hsa041450.40080508
140Chemical carcinogenesis_Homo sapiens_hsa052040.39919776
141Vascular smooth muscle contraction_Homo sapiens_hsa042700.39912482
142beta-Alanine metabolism_Homo sapiens_hsa004100.38548728
143Tryptophan metabolism_Homo sapiens_hsa003800.38112177
144Hepatitis B_Homo sapiens_hsa051610.37844887
145Legionellosis_Homo sapiens_hsa051340.37387177
146Starch and sucrose metabolism_Homo sapiens_hsa005000.37320061
147Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.36987323

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