ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of hexokinase activity (GO:1903299)	5.52384241
2	regulation of glucokinase activity (GO:0033131)	5.52384241
3	somite rostral/caudal axis specification (GO:0032525)	5.47367096
4	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	5.35621166
5	cilium or flagellum-dependent cell motility (GO:0001539)	4.71270992
6	epithelial cilium movement (GO:0003351)	4.61430667
7	positive regulation of gastrulation (GO:2000543)	4.51391886
8	axoneme assembly (GO:0035082)	4.47300774
9	cilium movement (GO:0003341)	4.26545646
10	protein localization to cilium (GO:0061512)	4.00574807
11	establishment of protein localization to Golgi (GO:0072600)	3.91995584
12	kidney morphogenesis (GO:0060993)	3.91435013
13	protein targeting to Golgi (GO:0000042)	3.89563962
14	nonmotile primary cilium assembly (GO:0035058)	3.88335409
15	neural tube formation (GO:0001841)	3.80760264
16	regulation of cilium movement (GO:0003352)	3.74767076
17	protein polyglutamylation (GO:0018095)	3.74217336
18	endocrine pancreas development (GO:0031018)	3.72051162
19	cellular ketone body metabolic process (GO:0046950)	3.61057640
20	retrograde transport, vesicle recycling within Golgi (GO:0000301)	3.54942939
21	dorsal/ventral neural tube patterning (GO:0021904)	3.51794476
22	signal transduction involved in regulation of gene expression (GO:0023019)	3.49315729
23	intraciliary transport (GO:0042073)	3.47810035
24	adult feeding behavior (GO:0008343)	3.40418627
25	inositol phosphate catabolic process (GO:0071545)	3.39430165
26	microtubule severing (GO:0051013)	3.36340881
27	inositol phosphate dephosphorylation (GO:0046855)	3.31036646
28	phosphorylated carbohydrate dephosphorylation (GO:0046838)	3.31036646
29	axonemal dynein complex assembly (GO:0070286)	3.31021000
30	limb bud formation (GO:0060174)	3.25885726
31	neuronal action potential propagation (GO:0019227)	3.23755581
32	brain morphogenesis (GO:0048854)	3.23365927
33	glycosphingolipid biosynthetic process (GO:0006688)	3.20695926
34	cilium organization (GO:0044782)	3.20241280
35	ketone body metabolic process (GO:1902224)	3.18242219
36	retinal ganglion cell axon guidance (GO:0031290)	3.13660703
37	cilium assembly (GO:0042384)	3.10892722
38	hindbrain development (GO:0030902)	3.05625271
39	heme transport (GO:0015886)	3.04638687
40	left/right axis specification (GO:0070986)	3.03916371
41	fucose catabolic process (GO:0019317)	3.03816477
42	L-fucose metabolic process (GO:0042354)	3.03816477
43	L-fucose catabolic process (GO:0042355)	3.03816477
44	photoreceptor cell maintenance (GO:0045494)	3.02915653
45	protein localization to Golgi apparatus (GO:0034067)	3.02129314
46	primitive streak formation (GO:0090009)	3.00890007
47	cilium morphogenesis (GO:0060271)	2.92746263
48	sperm motility (GO:0030317)	2.89624487
49	intra-Golgi vesicle-mediated transport (GO:0006891)	2.87704940
50	dendritic spine morphogenesis (GO:0060997)	2.85325841
51	chemosensory behavior (GO:0007635)	2.84877960
52	regulation of appetite (GO:0032098)	2.82986167
53	negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)	2.81017079
54	axonal fasciculation (GO:0007413)	2.80627857
55	polyol catabolic process (GO:0046174)	2.80204386
56	acrosome reaction (GO:0007340)	2.77886843
57	pancreas development (GO:0031016)	2.76974083
58	protein-cofactor linkage (GO:0018065)	2.76503058
59	microtubule depolymerization (GO:0007019)	2.75350126
60	prostate gland growth (GO:0060736)	2.70526185
61	negative regulation of neurological system process (GO:0031645)	2.65499158
62	smoothened signaling pathway (GO:0007224)	2.65286274
63	presynaptic membrane organization (GO:0097090)	2.63970648
64	pyrimidine nucleobase catabolic process (GO:0006208)	2.62599847
65	nucleobase catabolic process (GO:0046113)	2.61389112
66	regulation of response to food (GO:0032095)	2.60768842
67	cellular component assembly involved in morphogenesis (GO:0010927)	2.60685365
68	spinal cord motor neuron differentiation (GO:0021522)	2.59688409
69	platelet dense granule organization (GO:0060155)	2.59362828
70	glycolipid biosynthetic process (GO:0009247)	2.58241765
71	embryonic axis specification (GO:0000578)	2.55206148
72	positive regulation of embryonic development (GO:0040019)	2.54883991
73	GPI anchor metabolic process (GO:0006505)	2.54036916
74	eye photoreceptor cell differentiation (GO:0001754)	2.51399475
75	photoreceptor cell differentiation (GO:0046530)	2.51399475
76	dopaminergic neuron differentiation (GO:0071542)	2.49019442
77	tryptophan catabolic process (GO:0006569)	2.47725991
78	indole-containing compound catabolic process (GO:0042436)	2.47725991
79	indolalkylamine catabolic process (GO:0046218)	2.47725991
80	startle response (GO:0001964)	2.47552123
81	otic vesicle formation (GO:0030916)	2.45782472
82	embryonic epithelial tube formation (GO:0001838)	2.42603482
83	glycerophospholipid catabolic process (GO:0046475)	2.42562269
84	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.40021106
85	motile cilium assembly (GO:0044458)	2.39847425
86	limb development (GO:0060173)	2.39799966
87	appendage development (GO:0048736)	2.39799966
88	negative regulation of JUN kinase activity (GO:0043508)	2.38353227
89	positive regulation of glycolytic process (GO:0045821)	2.37977466
90	iron coordination entity transport (GO:1901678)	2.37022671
91	retinal cone cell development (GO:0046549)	2.36947776
92	magnesium ion transport (GO:0015693)	2.36477007
93	olfactory bulb development (GO:0021772)	2.36438584
94	embryonic retina morphogenesis in camera-type eye (GO:0060059)	2.35909981
95	cornea development in camera-type eye (GO:0061303)	2.35645420
96	indolalkylamine metabolic process (GO:0006586)	2.34748262
97	spermatid development (GO:0007286)	2.34640038
98	preassembly of GPI anchor in ER membrane (GO:0016254)	2.34502774
99	peptidyl-cysteine modification (GO:0018198)	2.33320495
100	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.33179853

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.94423822
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.31088974
3	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.90709020
4	IGF1R_20145208_ChIP-Seq_DFB_Human	2.72646256
5	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.71134106
6	GBX2_23144817_ChIP-Seq_PC3_Human	2.70403333
7	VDR_22108803_ChIP-Seq_LS180_Human	2.68468528
8	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.53375625
9	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.47117687
10	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.39097995
11	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.29428585
12	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.22501789
13	P300_19829295_ChIP-Seq_ESCs_Human	2.17256616
14	TAF15_26573619_Chip-Seq_HEK293_Human	2.15264631
15	FUS_26573619_Chip-Seq_HEK293_Human	2.08737748
16	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.06648399
17	EWS_26573619_Chip-Seq_HEK293_Human	1.92659742
18	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.89870978
19	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.89864609
20	SMAD4_21799915_ChIP-Seq_A2780_Human	1.89568062
21	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.83455986
22	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.80274374
23	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.80042877
24	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.78136303
25	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.74614748
26	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.74513447
27	AR_25329375_ChIP-Seq_VCAP_Human	1.68848290
28	ER_23166858_ChIP-Seq_MCF-7_Human	1.68846906
29	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.67741551
30	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.61324085
31	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.60913927
32	CBP_20019798_ChIP-Seq_JUKART_Human	1.60913927
33	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.60420154
34	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.60405540
35	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.59955127
36	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.59797222
37	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.57199584
38	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.56946902
39	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.54128783
40	RNF2_27304074_Chip-Seq_NSC_Mouse	1.53697344
41	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.51588422
42	BCAT_22108803_ChIP-Seq_LS180_Human	1.47813264
43	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.47091394
44	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.46715955
45	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.45762594
46	STAT3_23295773_ChIP-Seq_U87_Human	1.45317323
47	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.45217504
48	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.44881348
49	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.42620457
50	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.41055178
51	REST_21632747_ChIP-Seq_MESCs_Mouse	1.37721955
52	TCF4_23295773_ChIP-Seq_U87_Human	1.36865345
53	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.34731587
54	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.34321270
55	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.33558131
56	NANOG_19829295_ChIP-Seq_ESCs_Human	1.32990277
57	SOX2_19829295_ChIP-Seq_ESCs_Human	1.32990277
58	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.28334347
59	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.27254440
60	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.27254440
61	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.25508457
62	RUNX2_22187159_ChIP-Seq_PCA_Human	1.24414641
63	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.23279145
64	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.22509018
65	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.21874157
66	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.20243065
67	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.19148008
68	P53_22387025_ChIP-Seq_ESCs_Mouse	1.18327055
69	TCF4_22108803_ChIP-Seq_LS180_Human	1.15822655
70	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.14353148
71	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.14303075
72	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.14158474
73	IRF1_19129219_ChIP-ChIP_H3396_Human	1.12077522
74	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.11886290
75	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.11331213
76	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.11211183
77	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.11149431
78	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.10317807
79	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.10272892
80	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.10272892
81	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.08824965
82	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.08562307
83	TP53_22573176_ChIP-Seq_HFKS_Human	1.08383225
84	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.08284656
85	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.07175357
86	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.06713012
87	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.06293703
88	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.04974525
89	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.04318101
90	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.04212912
91	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.03185834
92	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.02073977
93	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.02072835
94	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.01505018
95	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.01157272
96	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.00431511
97	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.99894631
98	EST1_17652178_ChIP-ChIP_JURKAT_Human	0.99789775
99	HTT_18923047_ChIP-ChIP_STHdh_Human	0.98840028
100	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.98787095

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003195_calcinosis	3.76127621
2	MP0003122_maternal_imprinting	3.46749580
3	MP0003890_abnormal_embryonic-extraembry	2.94077359
4	MP0005645_abnormal_hypothalamus_physiol	2.64985808
5	MP0003880_abnormal_central_pattern	2.53687300
6	MP0008877_abnormal_DNA_methylation	2.43596318
7	MP0002102_abnormal_ear_morphology	2.26532403
8	MP0001984_abnormal_olfaction	2.25263439
9	MP0004133_heterotaxia	2.23129559
10	MP0008995_early_reproductive_senescence	2.20456179
11	MP0000569_abnormal_digit_pigmentation	2.17996754
12	MP0002837_dystrophic_cardiac_calcinosis	2.16066453
13	MP0003787_abnormal_imprinting	2.16051755
14	MP0005253_abnormal_eye_physiology	1.96030571
15	MP0009046_muscle_twitch	1.94199199
16	MP0006072_abnormal_retinal_apoptosis	1.92927740
17	MP0001529_abnormal_vocalization	1.88914291
18	MP0009780_abnormal_chondrocyte_physiolo	1.86166487
19	MP0003011_delayed_dark_adaptation	1.82480433
20	MP0005367_renal/urinary_system_phenotyp	1.81931220
21	MP0000516_abnormal_urinary_system	1.81931220
22	MP0002822_catalepsy	1.81345418
23	MP0004270_analgesia	1.80945317
24	MP0003121_genomic_imprinting	1.77378646
25	MP0002909_abnormal_adrenal_gland	1.75343671
26	MP0001986_abnormal_taste_sensitivity	1.75008163
27	MP0008789_abnormal_olfactory_epithelium	1.74080779
28	MP0006292_abnormal_olfactory_placode	1.72162232
29	MP0005551_abnormal_eye_electrophysiolog	1.69474589
30	MP0005394_taste/olfaction_phenotype	1.64603303
31	MP0005499_abnormal_olfactory_system	1.64603303
32	MP0002234_abnormal_pharynx_morphology	1.63768483
33	MP0003119_abnormal_digestive_system	1.60234815
34	MP0000631_abnormal_neuroendocrine_gland	1.57657686
35	MP0002938_white_spotting	1.57229600
36	MP0003283_abnormal_digestive_organ	1.48593193
37	MP0001944_abnormal_pancreas_morphology	1.45378864
38	MP0002557_abnormal_social/conspecific_i	1.40995117
39	MP0010386_abnormal_urinary_bladder	1.37811541
40	MP0002160_abnormal_reproductive_system	1.36002523
41	MP0006054_spinal_hemorrhage	1.35878363
42	MP0002736_abnormal_nociception_after	1.35603510
43	MP0001968_abnormal_touch/_nociception	1.34428966
44	MP0002277_abnormal_respiratory_mucosa	1.32893692
45	MP0000383_abnormal_hair_follicle	1.31309777
46	MP0002751_abnormal_autonomic_nervous	1.30713599
47	MP0002064_seizures	1.28681832
48	MP0009745_abnormal_behavioral_response	1.28194208
49	MP0002090_abnormal_vision	1.24698010
50	MP0005386_behavior/neurological_phenoty	1.24634672
51	MP0004924_abnormal_behavior	1.24634672
52	MP0002734_abnormal_mechanical_nocicepti	1.21753093
53	MP0000778_abnormal_nervous_system	1.20283513
54	MP0010678_abnormal_skin_adnexa	1.18929068
55	MP0002638_abnormal_pupillary_reflex	1.18759710
56	MP0005379_endocrine/exocrine_gland_phen	1.18370824
57	MP0005646_abnormal_pituitary_gland	1.16739533
58	MP0005410_abnormal_fertilization	1.16024515
59	MP0001485_abnormal_pinna_reflex	1.15345577
60	MP0004142_abnormal_muscle_tone	1.14159145
61	MP0002254_reproductive_system_inflammat	1.10628893
62	MP0002272_abnormal_nervous_system	1.10424882
63	MP0010329_abnormal_lipoprotein_level	1.08837923
64	MP0001486_abnormal_startle_reflex	1.05850620
65	MP0001905_abnormal_dopamine_level	1.05668972
66	MP0002653_abnormal_ependyma_morphology	1.04650336
67	MP0003937_abnormal_limbs/digits/tail_de	1.04578070
68	MP0002233_abnormal_nose_morphology	1.04534741
69	MP0003123_paternal_imprinting	1.02455093
70	MP0002876_abnormal_thyroid_physiology	1.01290007
71	MP0000647_abnormal_sebaceous_gland	1.00339367
72	MP0005391_vision/eye_phenotype	0.99336773
73	MP0002067_abnormal_sensory_capabilities	0.98372802
74	MP0002693_abnormal_pancreas_physiology	0.98155303
75	MP0002735_abnormal_chemical_nociception	0.97796891
76	MP0001929_abnormal_gametogenesis	0.94957676
77	MP0000427_abnormal_hair_cycle	0.94794583
78	MP0002572_abnormal_emotion/affect_behav	0.94482198
79	MP0003635_abnormal_synaptic_transmissio	0.92202684
80	MP0001756_abnormal_urination	0.91502272
81	MP0003698_abnormal_male_reproductive	0.90361839
82	MP0005085_abnormal_gallbladder_physiolo	0.89900661
83	MP0005195_abnormal_posterior_eye	0.87416310
84	MP0008872_abnormal_physiological_respon	0.85937481
85	MP0004134_abnormal_chest_morphology	0.84363977
86	MP0001293_anophthalmia	0.83865625
87	MP0003938_abnormal_ear_development	0.83163821
88	MP0001764_abnormal_homeostasis	0.83098103
89	MP0001970_abnormal_pain_threshold	0.79189845
90	MP0005248_abnormal_Harderian_gland	0.78956419
91	MP0002184_abnormal_innervation	0.78923178
92	MP0004145_abnormal_muscle_electrophysio	0.78630609
93	MP0002163_abnormal_gland_morphology	0.77673306
94	MP0001501_abnormal_sleep_pattern	0.77376673
95	MP0008875_abnormal_xenobiotic_pharmacok	0.76599457
96	MP0004019_abnormal_vitamin_homeostasis	0.76230297
97	MP0002882_abnormal_neuron_morphology	0.76133394
98	MP0002229_neurodegeneration	0.76019551
99	MP0002928_abnormal_bile_duct	0.75065595
100	MP0002069_abnormal_eating/drinking_beha	0.74866012

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hypoglycemic coma (HP:0001325)	3.86251361
2	Absent/shortened dynein arms (HP:0200106)	3.77628961
3	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.77628961
4	Medial flaring of the eyebrow (HP:0010747)	3.68539423
5	Hypothermia (HP:0002045)	3.67050235
6	Chronic hepatic failure (HP:0100626)	3.45573497
7	Tubulointerstitial nephritis (HP:0001970)	3.25071828
8	Molar tooth sign on MRI (HP:0002419)	3.21665132
9	Abnormality of midbrain morphology (HP:0002418)	3.21665132
10	Abnormality of the renal cortex (HP:0011035)	3.20398090
11	Intestinal atresia (HP:0011100)	3.20236536
12	Gait imbalance (HP:0002141)	3.18617148
13	Congenital primary aphakia (HP:0007707)	3.17764698
14	Hyperventilation (HP:0002883)	3.10386549
15	Hypoglycemic seizures (HP:0002173)	3.09116431
16	Nephronophthisis (HP:0000090)	3.06865363
17	Septo-optic dysplasia (HP:0100842)	2.98242513
18	Renal cortical cysts (HP:0000803)	2.98016310
19	Genital tract atresia (HP:0001827)	2.90048135
20	Unilateral renal agenesis (HP:0000122)	2.89908780
21	Abnormal respiratory motile cilium morphology (HP:0005938)	2.89371601
22	Abnormal respiratory epithelium morphology (HP:0012253)	2.89371601
23	Vaginal atresia (HP:0000148)	2.89301926
24	Bony spicule pigmentary retinopathy (HP:0007737)	2.87476435
25	Abnormal ciliary motility (HP:0012262)	2.86629895
26	Hyperinsulinemic hypoglycemia (HP:0000825)	2.83030221
27	Nephrogenic diabetes insipidus (HP:0009806)	2.75663501
28	Abnormal drinking behavior (HP:0030082)	2.63691494
29	Polydipsia (HP:0001959)	2.63691494
30	Pancreatic fibrosis (HP:0100732)	2.62716184
31	Pancreatic cysts (HP:0001737)	2.59015421
32	Abnormality of the renal medulla (HP:0100957)	2.58535239
33	Limb dystonia (HP:0002451)	2.54166980
34	Tubular atrophy (HP:0000092)	2.53905570
35	True hermaphroditism (HP:0010459)	2.50331565
36	Abnormal respiratory motile cilium physiology (HP:0012261)	2.48190485
37	Hypomagnesemia (HP:0002917)	2.45573190
38	Disproportionate short-trunk short stature (HP:0003521)	2.43708475
39	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.43459337
40	Abnormality of the fovea (HP:0000493)	2.39071707
41	Attenuation of retinal blood vessels (HP:0007843)	2.37620175
42	Bifid tongue (HP:0010297)	2.32921424
43	Tubulointerstitial abnormality (HP:0001969)	2.27240595
44	Hemiparesis (HP:0001269)	2.26098563
45	Abnormal rod and cone electroretinograms (HP:0008323)	2.24606145
46	Labial hypoplasia (HP:0000066)	2.23564828
47	Large for gestational age (HP:0001520)	2.23509925
48	Poor coordination (HP:0002370)	2.23293013
49	Anencephaly (HP:0002323)	2.20094014
50	Epileptiform EEG discharges (HP:0011182)	2.18860892
51	Absent septum pellucidum (HP:0001331)	2.18546539
52	Glycosuria (HP:0003076)	2.17863697
53	Abnormality of urine glucose concentration (HP:0011016)	2.17863697
54	Polyphagia (HP:0002591)	2.17174380
55	Increased circulating renin level (HP:0000848)	2.15730858
56	Severe Myopia (HP:0011003)	2.15643096
57	EEG with generalized epileptiform discharges (HP:0011198)	2.14894386
58	Polyuria (HP:0000103)	2.11330343
59	Postaxial hand polydactyly (HP:0001162)	2.10479960
60	Congenital malformation of the right heart (HP:0011723)	2.09577878
61	Double outlet right ventricle (HP:0001719)	2.09577878
62	Anosmia (HP:0000458)	2.08764583
63	Supernumerary spleens (HP:0009799)	2.07846197
64	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.07540083
65	Hypogonadotrophic hypogonadism (HP:0000044)	2.06174727
66	Abnormality of the labia minora (HP:0012880)	2.04342748
67	Progressive macrocephaly (HP:0004481)	2.03865862
68	Hypsarrhythmia (HP:0002521)	2.01246422
69	Rhinitis (HP:0012384)	2.01117605
70	Symptomatic seizures (HP:0011145)	1.99338359
71	Congenital hepatic fibrosis (HP:0002612)	1.98235115
72	Tongue fasciculations (HP:0001308)	1.98219630
73	Abnormality of endocrine pancreas physiology (HP:0012093)	1.97641891
74	Abnormality of the pancreatic islet cells (HP:0006476)	1.97641891
75	Acute necrotizing encephalopathy (HP:0006965)	1.96387843
76	Hypoplastic female external genitalia (HP:0012815)	1.93386255
77	Optic nerve hypoplasia (HP:0000609)	1.92721014
78	Broad-based gait (HP:0002136)	1.92267380
79	Hyperglycemia (HP:0003074)	1.88784595
80	Short tibia (HP:0005736)	1.86727318
81	Ketoacidosis (HP:0001993)	1.86335319
82	Cystic liver disease (HP:0006706)	1.86257082
83	Methylmalonic acidemia (HP:0002912)	1.84500611
84	Oligodactyly (hands) (HP:0001180)	1.83166896
85	Abnormality of macular pigmentation (HP:0008002)	1.82838815
86	Growth hormone deficiency (HP:0000824)	1.81552389
87	Aqueductal stenosis (HP:0002410)	1.81368086
88	Bilateral microphthalmos (HP:0007633)	1.81169735
89	Hepatoblastoma (HP:0002884)	1.81148061
90	Abnormal hair whorl (HP:0010721)	1.81145101
91	Neoplasm of the adrenal cortex (HP:0100641)	1.80981654
92	Hepatic necrosis (HP:0002605)	1.78943507
93	Cupped ear (HP:0000378)	1.77948432
94	Acute encephalopathy (HP:0006846)	1.77553451
95	Generalized myoclonic seizures (HP:0002123)	1.76805078
96	Specific learning disability (HP:0001328)	1.76017957
97	Abnormal urine output (HP:0012590)	1.74807432
98	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.73891468
99	Increased CSF lactate (HP:0002490)	1.73541462
100	Poor suck (HP:0002033)	1.73000017

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.66564922
2	MAP4K2	3.40346216
3	TRIM28	3.00983203
4	ACVR1B	2.93691479
5	WNK3	2.92608575
6	ERBB3	2.63852643
7	CASK	2.60918188
8	FGFR2	2.47536329
9	IRAK2	2.40251891
10	EPHA4	2.37652562
11	BMPR1B	2.25783174
12	MAP3K4	2.18634756
13	NTRK3	2.16173445
14	NLK	1.96633954
15	EPHA3	1.71585904
16	TIE1	1.62951045
17	MAPK15	1.61418035
18	GRK1	1.54582473
19	MAP2K7	1.51238819
20	PLK2	1.48408218
21	MARK1	1.47376836
22	PHKG1	1.47135686
23	PHKG2	1.47135686
24	CSNK1G1	1.44415739
25	MAPK13	1.44274658
26	AKT3	1.43750444
27	ADRBK2	1.43148681
28	ZAK	1.42363359
29	PTK2B	1.38549930
30	DAPK2	1.36976009
31	INSRR	1.35909034
32	PAK3	1.31988806
33	DYRK3	1.31325609
34	MAP3K2	1.28277220
35	STK38L	1.09714455
36	PRKCE	1.06878657
37	SGK2	1.03685832
38	PRKCG	1.03540234
39	BCR	0.96930077
40	UHMK1	0.96445263
41	CSNK1G2	0.95956923
42	DYRK2	0.93177732
43	TAF1	0.92772476
44	MKNK2	0.92603635
45	FER	0.91005082
46	PNCK	0.89958264
47	TGFBR1	0.89604411
48	BRD4	0.88811054
49	DYRK1A	0.88125364
50	LIMK1	0.85424297
51	IRAK1	0.81534245
52	CSNK1G3	0.80443730
53	PLK3	0.78205141
54	CAMKK2	0.77800380
55	MKNK1	0.77763964
56	CSNK1A1L	0.76513901
57	BRSK2	0.71831228
58	PLK4	0.69674587
59	NUAK1	0.69362472
60	SGK223	0.68212127
61	SGK494	0.68212127
62	EPHB1	0.66685288
63	MST4	0.66658947
64	PASK	0.62969912
65	VRK1	0.62715505
66	TNIK	0.58877823
67	ADRBK1	0.57790177
68	OXSR1	0.54428710
69	TESK1	0.48137289
70	TGFBR2	0.46315171
71	CHUK	0.45012095
72	SGK3	0.44947766
73	STK16	0.44502053
74	STK11	0.41750412
75	NTRK2	0.41699194
76	TLK1	0.40559420
77	MINK1	0.39822069
78	PRKG1	0.39769022
79	YES1	0.39699285
80	MUSK	0.39365918
81	PRKAA2	0.38628320
82	PDK2	0.38126938
83	PRKAA1	0.37946120
84	FGFR3	0.37634755
85	CSNK1A1	0.36480642
86	TSSK6	0.36203137
87	EIF2AK1	0.36136951
88	PRKACA	0.36023512
89	STK39	0.33691912
90	MAP2K4	0.33147666
91	CAMK2A	0.33026126
92	STK38	0.31210998
93	PRKACB	0.30520365
94	SRPK1	0.30147202
95	PRKCB	0.29407134
96	CAMK2B	0.26541610
97	DYRK1B	0.26537026
98	WNK4	0.26216712
99	SGK1	0.25935900
100	CDK8	0.25661274

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Maturity onset diabetes of the young_Homo sapiens_hsa04950	5.05008520
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.82571760
3	Protein export_Homo sapiens_hsa03060	2.77497230
4	Butanoate metabolism_Homo sapiens_hsa00650	2.67780115
5	Collecting duct acid secretion_Homo sapiens_hsa04966	2.48984868
6	Oxidative phosphorylation_Homo sapiens_hsa00190	2.30352635
7	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.29403967
8	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.04683467
9	Tryptophan metabolism_Homo sapiens_hsa00380	1.78938108
10	Regulation of autophagy_Homo sapiens_hsa04140	1.78423106
11	Phototransduction_Homo sapiens_hsa04744	1.76965766
12	Insulin secretion_Homo sapiens_hsa04911	1.71760598
13	Fatty acid elongation_Homo sapiens_hsa00062	1.71649369
14	Caffeine metabolism_Homo sapiens_hsa00232	1.65006559
15	Ether lipid metabolism_Homo sapiens_hsa00565	1.64187279
16	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.57717199
17	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.46404356
18	ABC transporters_Homo sapiens_hsa02010	1.46165498
19	Parkinsons disease_Homo sapiens_hsa05012	1.45498550
20	Linoleic acid metabolism_Homo sapiens_hsa00591	1.41422291
21	Huntingtons disease_Homo sapiens_hsa05016	1.38584422
22	Taste transduction_Homo sapiens_hsa04742	1.36985721
23	Circadian entrainment_Homo sapiens_hsa04713	1.36741612
24	Basal transcription factors_Homo sapiens_hsa03022	1.33287067
25	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.27782750
26	Peroxisome_Homo sapiens_hsa04146	1.25597913
27	Selenocompound metabolism_Homo sapiens_hsa00450	1.24842750
28	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.24799697
29	Steroid biosynthesis_Homo sapiens_hsa00100	1.24073619
30	Dopaminergic synapse_Homo sapiens_hsa04728	1.24073257
31	Nicotine addiction_Homo sapiens_hsa05033	1.23233194
32	Nitrogen metabolism_Homo sapiens_hsa00910	1.19080706
33	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.15406464
34	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.13382818
35	Sulfur metabolism_Homo sapiens_hsa00920	1.10569241
36	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.09795739
37	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.09072139
38	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.05334012
39	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.03928476
40	Olfactory transduction_Homo sapiens_hsa04740	1.03695788
41	Glutamatergic synapse_Homo sapiens_hsa04724	1.02722911
42	GABAergic synapse_Homo sapiens_hsa04727	1.01204410
43	Cocaine addiction_Homo sapiens_hsa05030	1.00613713
44	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.00559407
45	Sphingolipid metabolism_Homo sapiens_hsa00600	0.98592791
46	Histidine metabolism_Homo sapiens_hsa00340	0.98306055
47	RNA degradation_Homo sapiens_hsa03018	0.97903854
48	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.97160378
49	Fanconi anemia pathway_Homo sapiens_hsa03460	0.96437547
50	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.91297252
51	Alzheimers disease_Homo sapiens_hsa05010	0.91066909
52	Serotonergic synapse_Homo sapiens_hsa04726	0.90561281
53	Fatty acid degradation_Homo sapiens_hsa00071	0.90135400
54	Retinol metabolism_Homo sapiens_hsa00830	0.89151446
55	Fat digestion and absorption_Homo sapiens_hsa04975	0.87247299
56	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.85819243
57	Morphine addiction_Homo sapiens_hsa05032	0.85257832
58	Amphetamine addiction_Homo sapiens_hsa05031	0.85107438
59	Propanoate metabolism_Homo sapiens_hsa00640	0.82412266
60	beta-Alanine metabolism_Homo sapiens_hsa00410	0.80374098
61	Fatty acid metabolism_Homo sapiens_hsa01212	0.78182215
62	Circadian rhythm_Homo sapiens_hsa04710	0.75830198
63	Arginine and proline metabolism_Homo sapiens_hsa00330	0.74109437
64	Cardiac muscle contraction_Homo sapiens_hsa04260	0.72821327
65	Chemical carcinogenesis_Homo sapiens_hsa05204	0.72516284
66	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.72130398
67	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.71473689
68	Renin-angiotensin system_Homo sapiens_hsa04614	0.69780999
69	Metabolic pathways_Homo sapiens_hsa01100	0.67848431
70	Mineral absorption_Homo sapiens_hsa04978	0.66462201
71	Tyrosine metabolism_Homo sapiens_hsa00350	0.64162448
72	Salivary secretion_Homo sapiens_hsa04970	0.59990809
73	Renin secretion_Homo sapiens_hsa04924	0.59957627
74	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.59337360
75	Vibrio cholerae infection_Homo sapiens_hsa05110	0.58794804
76	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.58297325
77	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.58156746
78	Pyruvate metabolism_Homo sapiens_hsa00620	0.58155642
79	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.57051006
80	RNA polymerase_Homo sapiens_hsa03020	0.54756639
81	Folate biosynthesis_Homo sapiens_hsa00790	0.54675853
82	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.54462487
83	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.52734411
84	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.52547488
85	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.52269420
86	Pancreatic secretion_Homo sapiens_hsa04972	0.51338458
87	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.51185795
88	Phenylalanine metabolism_Homo sapiens_hsa00360	0.51148461
89	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.50552919
90	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.50372308
91	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.48395186
92	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.48345467
93	Bile secretion_Homo sapiens_hsa04976	0.48153692
94	Basal cell carcinoma_Homo sapiens_hsa05217	0.47098243
95	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.47058220
96	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.46204271
97	Purine metabolism_Homo sapiens_hsa00230	0.46124889
98	Type II diabetes mellitus_Homo sapiens_hsa04930	0.44541902
99	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.44449135
100	Long-term depression_Homo sapiens_hsa04730	0.43465628

TCP11X1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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