TCP11X2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1binding of sperm to zona pellucida (GO:0007339)9.99921111
2cell-cell recognition (GO:0009988)9.63920802
3acrosome reaction (GO:0007340)9.34063379
4reproduction (GO:0000003)8.73324710
5epithelial cilium movement (GO:0003351)8.71307521
6cilium or flagellum-dependent cell motility (GO:0001539)8.69813899
7axonemal dynein complex assembly (GO:0070286)8.46267206
8spermatid development (GO:0007286)8.23236697
9motile cilium assembly (GO:0044458)7.76330513
10cilium movement (GO:0003341)6.99891639
11epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.93113492
12regulation of cilium movement (GO:0003352)6.92068589
13single fertilization (GO:0007338)6.84705108
14piRNA metabolic process (GO:0034587)6.69483071
15male meiosis (GO:0007140)6.62433396
16synaptonemal complex assembly (GO:0007130)6.52788497
17microtubule depolymerization (GO:0007019)6.49029048
18synaptonemal complex organization (GO:0070193)6.45259001
19sperm capacitation (GO:0048240)5.77827381
20fertilization (GO:0009566)5.68154469
21spermatogenesis (GO:0007283)5.67574346
22male gamete generation (GO:0048232)5.65606154
23somite rostral/caudal axis specification (GO:0032525)5.18844408
24gamete generation (GO:0007276)5.18147636
25regulation of hexokinase activity (GO:1903299)5.10839084
26regulation of glucokinase activity (GO:0033131)5.10839084
27negative regulation of inclusion body assembly (GO:0090084)5.02493220
28chromosome organization involved in meiosis (GO:0070192)4.98833148
29axoneme assembly (GO:0035082)4.94683030
30chromosome condensation (GO:0030261)4.79460402
31organic cation transport (GO:0015695)4.68122572
32glycerol ether metabolic process (GO:0006662)4.67719761
33cellular process involved in reproduction in multicellular organism (GO:0022412)4.67669703
34chaperone-mediated protein complex assembly (GO:0051131)4.64511507
35germ cell development (GO:0007281)4.63816044
36protein localization to cilium (GO:0061512)4.52619587
37ventricular system development (GO:0021591)4.52263618
38cell recognition (GO:0008037)4.48685002
39DNA packaging (GO:0006323)4.41371262
40regulation of inclusion body assembly (GO:0090083)4.33441212
41leukocyte migration involved in inflammatory response (GO:0002523)4.33009921
42ether metabolic process (GO:0018904)4.29636348
43leukocyte aggregation (GO:0070486)4.23970750
44intraciliary transport (GO:0042073)4.23354884
45DNA methylation involved in gamete generation (GO:0043046)4.20946554
46meiotic nuclear division (GO:0007126)4.20746398
47regulation of microtubule-based movement (GO:0060632)4.16773340
48left/right axis specification (GO:0070986)4.16583221
49positive regulation of gastrulation (GO:2000543)4.16385752
50cilium organization (GO:0044782)4.12624408
51calcium ion-dependent exocytosis (GO:0017156)4.10684247
52seminiferous tubule development (GO:0072520)4.07696445
53multicellular organismal reproductive process (GO:0048609)4.07394811
54sequestering of actin monomers (GO:0042989)4.06615795
55male meiosis I (GO:0007141)4.05628633
56cilium assembly (GO:0042384)4.04437693
57nonmotile primary cilium assembly (GO:0035058)4.01359306
58response to pheromone (GO:0019236)4.00058181
59cellular ketone body metabolic process (GO:0046950)3.99341680
60DNA replication-dependent nucleosome assembly (GO:0006335)3.98667221
61DNA replication-dependent nucleosome organization (GO:0034723)3.98667221
62establishment of protein localization to Golgi (GO:0072600)3.95504013
63spermatid nucleus differentiation (GO:0007289)3.94309853
64microtubule polymerization or depolymerization (GO:0031109)3.89284060
65microtubule severing (GO:0051013)3.87764346
66sequestering of metal ion (GO:0051238)3.86784897
67mitotic sister chromatid cohesion (GO:0007064)3.83598781
68protein targeting to Golgi (GO:0000042)3.78256281
69regulation of spindle checkpoint (GO:0090231)3.72891533
70protein localization to chromosome, centromeric region (GO:0071459)3.71975408
71dorsal/ventral neural tube patterning (GO:0021904)3.69099009
72limb bud formation (GO:0060174)3.63902489
73meiosis I (GO:0007127)3.61959198
74GTP biosynthetic process (GO:0006183)3.59162247
75left/right pattern formation (GO:0060972)3.57764841
76L-fucose catabolic process (GO:0042355)3.57202601
77fucose catabolic process (GO:0019317)3.57202601
78L-fucose metabolic process (GO:0042354)3.57202601
79brain morphogenesis (GO:0048854)3.55859238
80regulation of centriole replication (GO:0046599)3.55172866
81neural tube formation (GO:0001841)3.54243252
82glycolytic process (GO:0006096)3.53715822
83ketone body metabolic process (GO:1902224)3.51892728
84killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.42728225
85disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.42728225
86defense response to fungus (GO:0050832)3.42636519
87UTP biosynthetic process (GO:0006228)3.40501928
88meiotic cell cycle (GO:0051321)3.38759368
89retrograde transport, vesicle recycling within Golgi (GO:0000301)3.37424522
90monoubiquitinated protein deubiquitination (GO:0035520)3.35007975
91histone exchange (GO:0043486)3.30856893
92multicellular organismal development (GO:0007275)3.30704487
93sexual reproduction (GO:0019953)3.25781279
94single strand break repair (GO:0000012)3.25613779
95genitalia morphogenesis (GO:0035112)3.23338688
96synapsis (GO:0007129)3.22189033
97kidney morphogenesis (GO:0060993)3.20113506
98heme transport (GO:0015886)3.19752236
99endocrine pancreas development (GO:0031018)3.16633728
100cellular component assembly involved in morphogenesis (GO:0010927)3.15605639
101eye photoreceptor cell differentiation (GO:0001754)3.14833191
102photoreceptor cell differentiation (GO:0046530)3.14833191
103cilium morphogenesis (GO:0060271)3.14173865
104meiotic cell cycle process (GO:1903046)3.12671140
105UTP metabolic process (GO:0046051)3.10814171
106nucleoside diphosphate phosphorylation (GO:0006165)3.10453495
107gamma-aminobutyric acid transport (GO:0015812)3.07340366
108photoreceptor cell maintenance (GO:0045494)3.06493359
109signal transduction involved in regulation of gene expression (GO:0023019)3.03624201
110protein K11-linked deubiquitination (GO:0035871)3.02586765
111pyrimidine nucleobase catabolic process (GO:0006208)2.98443945
112primitive streak formation (GO:0090009)2.98009738
113negative regulation of organelle assembly (GO:1902116)2.95711264
114smoothened signaling pathway (GO:0007224)2.93862978
115alditol metabolic process (GO:0019400)2.92909968
116adult feeding behavior (GO:0008343)2.92545949
117chronic inflammatory response (GO:0002544)2.91264931
118protein localization to Golgi apparatus (GO:0034067)2.91200535
119neuronal action potential propagation (GO:0019227)2.87166420
120microtubule bundle formation (GO:0001578)2.85906859
121glycosphingolipid biosynthetic process (GO:0006688)2.83963999
122lactate metabolic process (GO:0006089)2.83749467
123limb development (GO:0060173)2.83047784
124appendage development (GO:0048736)2.83047784
125regulation of appetite (GO:0032098)2.80237761
126mitotic sister chromatid segregation (GO:0000070)2.80177450
127protein polyglutamylation (GO:0018095)2.79795434
128nuclear pore complex assembly (GO:0051292)2.78711321
129somite development (GO:0061053)2.78701448
130gene silencing by RNA (GO:0031047)2.78180376
131pancreas development (GO:0031016)2.77444600
132negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.73459169
133negative regulation of translation, ncRNA-mediated (GO:0040033)2.73459169
134regulation of translation, ncRNA-mediated (GO:0045974)2.73459169
135regulation of autophagic vacuole assembly (GO:2000785)2.72852310
136nucleobase catabolic process (GO:0046113)2.72575193
137retinal ganglion cell axon guidance (GO:0031290)2.71915668
138inositol phosphate catabolic process (GO:0071545)2.71620734
139embryonic axis specification (GO:0000578)2.67563610
140protein refolding (GO:0042026)2.67234757
141regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.66993469
142regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.64145485
143embryonic retina morphogenesis in camera-type eye (GO:0060059)2.63239331
144regulation of centrosome cycle (GO:0046605)2.60801914
145negative regulation of axon guidance (GO:1902668)2.60534105
146guanosine-containing compound biosynthetic process (GO:1901070)2.60281406
147spinal cord motor neuron differentiation (GO:0021522)2.60191959
148microtubule-based movement (GO:0007018)2.60120588
149polyol catabolic process (GO:0046174)2.58911952
150cell projection assembly (GO:0030031)2.58897507
151axonal fasciculation (GO:0007413)2.58838389
152phosphorylated carbohydrate dephosphorylation (GO:0046838)2.58309156
153inositol phosphate dephosphorylation (GO:0046855)2.58309156
154nuclear pore organization (GO:0006999)2.57746083
155chemosensory behavior (GO:0007635)2.57471171
156intra-Golgi vesicle-mediated transport (GO:0006891)2.56940635
157serotonin metabolic process (GO:0042428)2.56880100
158pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.56688421
159regulation of mesoderm development (GO:2000380)2.56215329
160startle response (GO:0001964)2.52782852
161negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.52544017
162magnesium ion transport (GO:0015693)2.50450795
163positive regulation of embryonic development (GO:0040019)2.50204769
164hindbrain development (GO:0030902)2.48309343
165DNA integration (GO:0015074)2.46396170
166primary amino compound metabolic process (GO:1901160)2.46123872
167iron coordination entity transport (GO:1901678)2.43238925
168determination of left/right symmetry (GO:0007368)2.41867394
169retina layer formation (GO:0010842)2.40181103
170platelet dense granule organization (GO:0060155)2.37771314
171regulation of response to food (GO:0032095)2.37470568
172Golgi to endosome transport (GO:0006895)2.36516363
173retinal cone cell development (GO:0046549)2.33124376
174dendritic spine morphogenesis (GO:0060997)2.32762303
175fusion of sperm to egg plasma membrane (GO:0007342)13.3485628
176sperm motility (GO:0030317)11.9336336
177acrosome assembly (GO:0001675)11.4039426
178sperm-egg recognition (GO:0035036)10.6611124
179cell wall macromolecule metabolic process (GO:0044036)10.4492554
180cell wall macromolecule catabolic process (GO:0016998)10.4492554
181multicellular organism reproduction (GO:0032504)10.2976569
182plasma membrane fusion (GO:0045026)10.2254616

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.14798519
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.82419837
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.55317955
4EZH2_22144423_ChIP-Seq_EOC_Human3.13330757
5GBX2_23144817_ChIP-Seq_PC3_Human2.93736086
6POU3F2_20337985_ChIP-ChIP_501MEL_Human2.89779272
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.83983881
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.82060404
9CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.72884922
10IGF1R_20145208_ChIP-Seq_DFB_Human2.69514681
11E2F7_22180533_ChIP-Seq_HELA_Human2.66601006
12PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.65256961
13CTBP2_25329375_ChIP-Seq_LNCAP_Human2.57922711
14BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.50921064
15CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.32078350
16ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.31203195
17FUS_26573619_Chip-Seq_HEK293_Human2.29762332
18CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.27898680
19ZNF274_21170338_ChIP-Seq_K562_Hela2.20457587
20P300_19829295_ChIP-Seq_ESCs_Human2.16470421
21CTBP1_25329375_ChIP-Seq_LNCAP_Human2.15872729
22PIAS1_25552417_ChIP-Seq_VCAP_Human2.11437327
23STAT6_21828071_ChIP-Seq_BEAS2B_Human2.04658340
24MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse11.6912598
25SMAD4_21799915_ChIP-Seq_A2780_Human1.97867480
26TAF15_26573619_Chip-Seq_HEK293_Human1.95380694
27FLI1_27457419_Chip-Seq_LIVER_Mouse1.90006483
28AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.89864203
29SMAD3_21741376_ChIP-Seq_EPCs_Human1.88950405
30MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.87594792
31E2F4_17652178_ChIP-ChIP_JURKAT_Human1.84610765
32KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.83116606
33EWS_26573619_Chip-Seq_HEK293_Human1.79879647
34FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.75465259
35ER_23166858_ChIP-Seq_MCF-7_Human1.75152810
36AR_21909140_ChIP-Seq_LNCAP_Human1.75024996
37SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.73352507
38TOP2B_26459242_ChIP-Seq_MCF-7_Human1.71341723
39SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.71070294
40AR_25329375_ChIP-Seq_VCAP_Human1.69628318
41BMI1_23680149_ChIP-Seq_NPCS_Mouse1.69507365
42GATA1_26923725_Chip-Seq_HPCs_Mouse1.68929956
43VDR_22108803_ChIP-Seq_LS180_Human1.68100248
44STAT1_17558387_ChIP-Seq_HELA_Human1.62958382
45UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.60871071
46MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.60621356
47NR3C1_21868756_ChIP-Seq_MCF10A_Human1.60087330
48STAT3_23295773_ChIP-Seq_U87_Human1.59795010
49OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.59378537
50SALL1_21062744_ChIP-ChIP_HESCs_Human1.58259967
51PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.57683385
52TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.57093307
53GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.55038739
54RNF2_27304074_Chip-Seq_NSC_Mouse1.54422911
55RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.54106404
56EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.53918238
57FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.53540613
58TCF4_23295773_ChIP-Seq_U87_Human1.52584379
59WDR5_24793694_ChIP-Seq_LNCAP_Human1.52472488
60CDX2_19796622_ChIP-Seq_MESCs_Mouse1.52287570
61SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.47556278
62TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.46929269
63NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.45539506
64SOX2_22085726_ChIP-Seq_NPCs_Mouse1.44235289
65BCAT_22108803_ChIP-Seq_LS180_Human1.42126141
66ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.40661394
67NANOG_18555785_Chip-Seq_ESCs_Mouse1.38807382
68REST_21632747_ChIP-Seq_MESCs_Mouse1.38642534
69KAP1_22055183_ChIP-Seq_ESCs_Mouse1.38429156
70MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.37728362
71PCGF2_27294783_Chip-Seq_ESCs_Mouse1.36544573
72RUNX2_22187159_ChIP-Seq_PCA_Human1.36089536
73GATA3_21867929_ChIP-Seq_CD8_Mouse1.34503088
74KLF5_20875108_ChIP-Seq_MESCs_Mouse1.33913332
75ELK4_26923725_Chip-Seq_MESODERM_Mouse1.33336536
76SOX2_19829295_ChIP-Seq_ESCs_Human1.32006100
77NANOG_19829295_ChIP-Seq_ESCs_Human1.32006100
78DROSHA_22980978_ChIP-Seq_HELA_Human1.30279282
79TCF4_22108803_ChIP-Seq_LS180_Human1.29089549
80LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.28757941
81EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.26149705
82EZH2_27294783_Chip-Seq_NPCs_Mouse1.25154548
83HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.25153337
84POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.25089384
85TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25089384
86EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.22981183
87PRDM14_20953172_ChIP-Seq_ESCs_Human1.21454020
88TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.21226173
89RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21000237
90P53_21459846_ChIP-Seq_SAOS-2_Human1.20350268
91GATA3_21867929_ChIP-Seq_TH1_Mouse1.20350084
92SMAD4_21741376_ChIP-Seq_EPCs_Human1.20196868
93TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19433682
94LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17348770
95SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.16724847
96TAL1_26923725_Chip-Seq_HPCs_Mouse1.14424576
97SMAD4_21741376_ChIP-Seq_HESCs_Human1.14304244
98FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.13869782
99CBX2_27304074_Chip-Seq_ESCs_Mouse1.13664522
100FOXA1_21572438_ChIP-Seq_LNCaP_Human1.13304383
101P53_22387025_ChIP-Seq_ESCs_Mouse1.12528081
102SMAD3_21741376_ChIP-Seq_ESCs_Human1.12075819
103E2F1_18555785_Chip-Seq_ESCs_Mouse1.10937217
104SOX2_21211035_ChIP-Seq_LN229_Gbm1.10787052
105KDM2B_26808549_Chip-Seq_REH_Human1.10617029
106CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.10274858
107PCGF2_27294783_Chip-Seq_NPCs_Mouse1.09879299
108ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.09628225
109ARNT_22903824_ChIP-Seq_MCF-7_Human1.09400838
110SMAD3_21741376_ChIP-Seq_HESCs_Human1.08057587
111SUZ12_18555785_Chip-Seq_ESCs_Mouse1.08050552
112EED_16625203_ChIP-ChIP_MESCs_Mouse1.07598132
113IRF1_19129219_ChIP-ChIP_H3396_Human1.07085126
114FOXA1_25329375_ChIP-Seq_VCAP_Human1.07039164
115FOXA1_27270436_Chip-Seq_PROSTATE_Human1.07039164
116TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.06160285
117GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05918262
118PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05750507
119FLI1_21867929_ChIP-Seq_TH2_Mouse1.04836166
120PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.04710040
121FOXM1_26456572_ChIP-Seq_MCF-7_Human1.04013991
122SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.03202990
123GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.03093723
124FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.03028646
125YY1_22570637_ChIP-Seq_MALME-3M_Human1.02855898
126RXR_22108803_ChIP-Seq_LS180_Human1.01606013
127SPI1_20517297_ChIP-Seq_HL60_Human1.01271205
128AUTS2_25519132_ChIP-Seq_293T-REX_Human1.00834967
129TP53_18474530_ChIP-ChIP_U2OS_Human1.00601653
130RAD21_21589869_ChIP-Seq_MESCs_Mouse0.99823066
131P300_18555785_Chip-Seq_ESCs_Mouse0.99477012
132TP53_22573176_ChIP-Seq_HFKS_Human0.99461259
133SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98284656
134CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96309112
135SOX9_26525672_Chip-Seq_HEART_Mouse0.96277960
136MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94719202
137PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.94093532
138SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93274001
139SPI1_26923725_Chip-Seq_HPCs_Mouse0.93080816
140NFE2_27457419_Chip-Seq_LIVER_Mouse0.92631299
141RBPJ_22232070_ChIP-Seq_NCS_Mouse0.92307888
142CBP_20019798_ChIP-Seq_JUKART_Human0.92205598
143IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.92205598
144ERG_20517297_ChIP-Seq_VCAP_Human0.90413180
145PHF8_20622854_ChIP-Seq_HELA_Human0.90402544
146RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.89993851
147RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.89125513
148SOX11_22085726_ChIP-Seq_ESNs_Mouse0.89027850
149BCOR_27268052_Chip-Seq_Bcells_Human0.88885841
150PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88852854
151RXRA_24833708_ChIP-Seq_LIVER_Mouse0.88380693
152PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.87768429
153RARA_24833708_ChIP-Seq_LIVER_Mouse0.87652353
154SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.86353849
155CRX_20693478_ChIP-Seq_RETINA_Mouse0.85907999
156CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.84863103
157ESET_19884257_ChIP-Seq_ESCs_Mouse0.84215861
158STAT1_20625510_ChIP-Seq_HELA_Human0.83439311
159FLI1_21867929_ChIP-Seq_CD8_Mouse0.83311133
160SRY_22984422_ChIP-ChIP_TESTIS_Rat0.82615336
161SUZ12_27294783_Chip-Seq_NPCs_Mouse0.82097420
162CTCF_26484167_Chip-Seq_Bcells_Mouse0.81884363
163LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.81745793
164EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.81177949
165ELF1_20517297_ChIP-Seq_JURKAT_Human0.80320781
166BCL6_27268052_Chip-Seq_Bcells_Human0.78990104
167MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.77930393
168TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.77824527
169E2F1_20622854_ChIP-Seq_HELA_Human0.77622001
170SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.76171339
171GF1_26923725_Chip-Seq_HPCs_Mouse0.74153801
172HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.74056206
173CTCF_18555785_ChIP-Seq_MESCs_Mouse0.72581580
174NANOG_20526341_ChIP-Seq_ESCs_Human0.72413821
175PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.71315960

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.42801230
2MP0001929_abnormal_gametogenesis5.14613530
3MP0008877_abnormal_DNA_methylation4.73172409
4MP0003122_maternal_imprinting3.64780703
5MP0003880_abnormal_central_pattern3.39520701
6MP0002210_abnormal_sex_determination3.27260815
7MP0002161_abnormal_fertility/fecundity2.97167490
8MP0003303_peritoneal_inflammation2.85967757
9MP0001145_abnormal_male_reproductive2.83637484
10MP0003195_calcinosis2.72971307
11MP0005645_abnormal_hypothalamus_physiol2.55134323
12MP0002653_abnormal_ependyma_morphology2.52682077
13MP0005670_abnormal_white_adipose2.40359960
14MP0000653_abnormal_sex_gland2.38897472
15MP0001984_abnormal_olfaction2.38012655
16MP0004270_analgesia2.26490383
17MP0003787_abnormal_imprinting2.25344542
18MP0010094_abnormal_chromosome_stability2.17199089
19MP0003283_abnormal_digestive_organ2.09220216
20MP0003693_abnormal_embryo_hatching2.05591284
21MP0005410_abnormal_fertilization14.3105470
22MP0001986_abnormal_taste_sensitivity1.97706633
23MP0002822_catalepsy1.90254566
24MP0002102_abnormal_ear_morphology1.87163592
25MP0002638_abnormal_pupillary_reflex1.85622068
26MP0008057_abnormal_DNA_replication1.85341809
27MP0005623_abnormal_meninges_morphology1.82995454
28MP0001529_abnormal_vocalization1.78852693
29MP0006292_abnormal_olfactory_placode1.76797033
30MP0002837_dystrophic_cardiac_calcinosis1.72636943
31MP0002160_abnormal_reproductive_system1.70580772
32MP0004147_increased_porphyrin_level1.70030246
33MP0003111_abnormal_nucleus_morphology1.69130662
34MP0000631_abnormal_neuroendocrine_gland1.65978094
35MP0003077_abnormal_cell_cycle1.63191790
36MP0002938_white_spotting1.62800778
37MP0000569_abnormal_digit_pigmentation1.59970581
38MP0008789_abnormal_olfactory_epithelium1.59301706
39MP0003119_abnormal_digestive_system1.56716877
40MP0004957_abnormal_blastocyst_morpholog1.55288647
41MP0008058_abnormal_DNA_repair1.54616310
42MP0000516_abnormal_urinary_system1.53694883
43MP0005367_renal/urinary_system_phenotyp1.53694883
44MP0005379_endocrine/exocrine_gland_phen1.52544835
45MP0002254_reproductive_system_inflammat1.50974769
46MP0009780_abnormal_chondrocyte_physiolo1.50249443
47MP0002277_abnormal_respiratory_mucosa1.49981713
48MP0002282_abnormal_trachea_morphology1.46129524
49MP0008007_abnormal_cellular_replicative1.42810246
50MP0005499_abnormal_olfactory_system1.40684823
51MP0005394_taste/olfaction_phenotype1.40684823
52MP0002751_abnormal_autonomic_nervous1.38792471
53MP0001968_abnormal_touch/_nociception1.38315104
54MP0001944_abnormal_pancreas_morphology1.37507725
55MP0002734_abnormal_mechanical_nocicepti1.37225096
56MP0002909_abnormal_adrenal_gland1.36622986
57MP0003136_yellow_coat_color1.36010197
58MP0004133_heterotaxia1.35674605
59MP0009745_abnormal_behavioral_response1.33949939
60MP0002557_abnormal_social/conspecific_i1.32457111
61MP0002064_seizures1.31008160
62MP0000427_abnormal_hair_cycle1.28617364
63MP0002735_abnormal_chemical_nociception1.22617396
64MP0002736_abnormal_nociception_after1.22017212
65MP0010386_abnormal_urinary_bladder1.21400343
66MP0004142_abnormal_muscle_tone1.21113001
67MP0004859_abnormal_synaptic_plasticity1.19351326
68MP0002090_abnormal_vision1.16874402
69MP0003937_abnormal_limbs/digits/tail_de1.16096815
70MP0001851_eye_inflammation1.12886520
71MP0001730_embryonic_growth_arrest1.11878067
72MP0002876_abnormal_thyroid_physiology1.11638060
73MP0001485_abnormal_pinna_reflex1.10717219
74MP0005386_behavior/neurological_phenoty1.09864694
75MP0004924_abnormal_behavior1.09864694
76MP0002733_abnormal_thermal_nociception1.08024897
77MP0010307_abnormal_tumor_latency1.06147878
78MP0002272_abnormal_nervous_system1.05834356
79MP0000778_abnormal_nervous_system1.05690674
80MP0002572_abnormal_emotion/affect_behav1.05540196
81MP0003878_abnormal_ear_physiology1.04892762
82MP0005377_hearing/vestibular/ear_phenot1.04892762
83MP0003635_abnormal_synaptic_transmissio1.04708508
84MP0002132_abnormal_respiratory_system1.03077456
85MP0002233_abnormal_nose_morphology1.02186600
86MP0003950_abnormal_plasma_membrane1.02147406
87MP0005646_abnormal_pituitary_gland1.00820253
88MP0001486_abnormal_startle_reflex1.00603054
89MP0001905_abnormal_dopamine_level0.99823343
90MP0000647_abnormal_sebaceous_gland0.98602849
91MP0008875_abnormal_xenobiotic_pharmacok0.97985583
92MP0006276_abnormal_autonomic_nervous0.97560834
93MP0003436_decreased_susceptibility_to0.96511215
94MP0001970_abnormal_pain_threshold0.95545628
95MP0002067_abnormal_sensory_capabilities0.93861632
96MP0009785_altered_susceptibility_to0.90102400
97MP0004233_abnormal_muscle_weight0.89893884
98MP0003011_delayed_dark_adaptation0.88770947
99MP0001188_hyperpigmentation0.88767662
100MP0003183_abnormal_peptide_metabolism0.87677075
101MP0002229_neurodegeneration0.87543152
102MP0000383_abnormal_hair_follicle0.85688356
103MP0005389_reproductive_system_phenotype0.83672886
104MP0001501_abnormal_sleep_pattern0.82479364
105MP0000350_abnormal_cell_proliferation0.82171929
106MP0002063_abnormal_learning/memory/cond0.81940302
107MP0010329_abnormal_lipoprotein_level0.81797337
108MP0002163_abnormal_gland_morphology0.80999217
109MP0003786_premature_aging0.80997108
110MP0005083_abnormal_biliary_tract0.80251578
111MP0002693_abnormal_pancreas_physiology0.79789793
112MP0005085_abnormal_gallbladder_physiolo0.79267344
113MP0000358_abnormal_cell_content/0.78143080
114MP0003123_paternal_imprinting0.76238928
115MP0005195_abnormal_posterior_eye0.75999013
116MP0005647_abnormal_sex_gland0.71851088
117MP0008932_abnormal_embryonic_tissue0.70796470
118MP0002405_respiratory_system_inflammati0.69669983
119MP0001765_abnormal_ion_homeostasis0.69032763
120MP0000313_abnormal_cell_death0.68800255
121MP0001697_abnormal_embryo_size0.67877713
122MP0002080_prenatal_lethality0.67029996
123MP0004197_abnormal_fetal_growth/weight/0.65678787
124MP0002269_muscular_atrophy0.65132924
125MP0004808_abnormal_hematopoietic_stem0.61283888
126MP0001672_abnormal_embryogenesis/_devel0.57195462
127MP0005380_embryogenesis_phenotype0.57195462
128MP0005076_abnormal_cell_differentiation0.57042521
129MP0002084_abnormal_developmental_patter0.55913437
130MP0008995_early_reproductive_senescence0.54241259
131MP0003656_abnormal_erythrocyte_physiolo0.53848476
132MP0003806_abnormal_nucleotide_metabolis0.53336162
133MP0006036_abnormal_mitochondrial_physio0.53105911
134MP0002085_abnormal_embryonic_tissue0.52494006
135MP0001545_abnormal_hematopoietic_system0.48460365
136MP0005397_hematopoietic_system_phenotyp0.48460365
137MP0002086_abnormal_extraembryonic_tissu0.47019371
138MP0001764_abnormal_homeostasis0.46266114
139MP0005253_abnormal_eye_physiology0.45263475
140MP0001873_stomach_inflammation0.45166430
141MP0004036_abnormal_muscle_relaxation0.44785450
142MP0002234_abnormal_pharynx_morphology0.44766561
143MP0009046_muscle_twitch0.43707786
144MP0001727_abnormal_embryo_implantation0.43003618
145MP0006072_abnormal_retinal_apoptosis0.41908957
146MP0003984_embryonic_growth_retardation0.40234585
147MP0003890_abnormal_embryonic-extraembry0.39697887
148MP0005666_abnormal_adipose_tissue0.39594008
149MP0002971_abnormal_brown_adipose0.39277139
150MP0005636_abnormal_mineral_homeostasis0.38584434
151MP0003699_abnormal_female_reproductive0.38379165
152MP0001533_abnormal_skeleton_physiology0.38027184
153MP0002088_abnormal_embryonic_growth/wei0.37422930
154MP0000733_abnormal_muscle_development0.36245678
155MP0003115_abnormal_respiratory_system0.36087317
156MP0003121_genomic_imprinting0.33472445
157MP0006035_abnormal_mitochondrial_morpho0.32953963
158MP0000462_abnormal_digestive_system0.32925861
159MP0004084_abnormal_cardiac_muscle0.32322759
160MP0005391_vision/eye_phenotype0.31957066
161MP0001293_anophthalmia0.31750076
162MP0003861_abnormal_nervous_system0.30864859
163MP0002970_abnormal_white_adipose0.30493434
164MP0003705_abnormal_hypodermis_morpholog0.30297680
165MP0003315_abnormal_perineum_morphology0.29877355
166MP0000749_muscle_degeneration0.27886587
167MP0002019_abnormal_tumor_incidence0.27167554
168MP0001119_abnormal_female_reproductive0.26684819
169MP0005266_abnormal_metabolism0.25595285
170MP0009672_abnormal_birth_weight0.24349085
171MP0005023_abnormal_wound_healing0.24194561
172MP0005551_abnormal_eye_electrophysiolog0.23885033
173MP0010352_gastrointestinal_tract_polyps0.23877982
174MP0010630_abnormal_cardiac_muscle0.23503198
175MP0002133_abnormal_respiratory_system0.22755122
176MP0005388_respiratory_system_phenotype0.22755122
177MP0008961_abnormal_basal_metabolism0.22693381

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.45738576
2Abnormal respiratory epithelium morphology (HP:0012253)9.21525883
3Abnormal respiratory motile cilium morphology (HP:0005938)9.21525883
4Abnormal ciliary motility (HP:0012262)7.83549231
5Chronic bronchitis (HP:0004469)7.69132450
6Rhinitis (HP:0012384)7.25026745
7Infertility (HP:0000789)6.39763800
8Nasal polyposis (HP:0100582)5.97292866
9Abnormality of the nasal mucosa (HP:0000433)4.81346811
10Bronchitis (HP:0012387)4.42550463
11Recurrent sinusitis (HP:0011108)4.34350121
12Male infertility (HP:0003251)4.10595823
13Bronchiectasis (HP:0002110)3.98838941
14Nephronophthisis (HP:0000090)3.83381470
15Chronic hepatic failure (HP:0100626)3.65293685
16Gait imbalance (HP:0002141)3.37083634
17Congenital primary aphakia (HP:0007707)3.36059305
18Genital tract atresia (HP:0001827)3.26820277
19Recurrent otitis media (HP:0000403)3.26660961
20Abnormal spermatogenesis (HP:0008669)3.25359065
21Pancreatic fibrosis (HP:0100732)3.19359735
22Disproportionate short-trunk short stature (HP:0003521)3.16696174
23Vaginal atresia (HP:0000148)3.13910617
24Septo-optic dysplasia (HP:0100842)3.12005656
25Intestinal atresia (HP:0011100)3.01880949
26Hyperventilation (HP:0002883)2.98680060
27True hermaphroditism (HP:0010459)2.92682734
28Nephrogenic diabetes insipidus (HP:0009806)2.84886220
29Abnormality of the renal medulla (HP:0100957)2.80105652
30Aplasia/Hypoplasia of the tibia (HP:0005772)2.75106083
31Hypoglycemic coma (HP:0001325)2.72467063
32Pancreatic cysts (HP:0001737)2.67300177
33Impulsivity (HP:0100710)2.67022282
34Hypothermia (HP:0002045)2.60971777
35Double outlet right ventricle (HP:0001719)2.57058447
36Congenital malformation of the right heart (HP:0011723)2.57058447
37Bony spicule pigmentary retinopathy (HP:0007737)2.56456409
38Hypoglycemic seizures (HP:0002173)2.49579507
39Short tibia (HP:0005736)2.45469797
40Gonadotropin excess (HP:0000837)2.44762355
41Unilateral renal agenesis (HP:0000122)2.43841608
42Attenuation of retinal blood vessels (HP:0007843)2.41532631
43Occipital encephalocele (HP:0002085)2.36023111
44Tubulointerstitial nephritis (HP:0001970)2.34266520
45Postaxial hand polydactyly (HP:0001162)2.32399166
46Abnormality of the fovea (HP:0000493)2.26600273
47Recurrent bronchitis (HP:0002837)2.24829139
48Renal cortical cysts (HP:0000803)2.24657358
49Molar tooth sign on MRI (HP:0002419)2.21332636
50Abnormality of midbrain morphology (HP:0002418)2.21332636
51Poor coordination (HP:0002370)2.21243681
52Abnormality of the lower motor neuron (HP:0002366)2.20256103
53Hyperinsulinemic hypoglycemia (HP:0000825)2.20250682
54Absent septum pellucidum (HP:0001331)2.16166754
55Anencephaly (HP:0002323)2.15565429
56Recurrent gram-negative bacterial infections (HP:0005420)2.09169098
57Tubular atrophy (HP:0000092)2.07767747
58Optic nerve hypoplasia (HP:0000609)2.04941593
59Hypoplasia of the capital femoral epiphysis (HP:0003090)2.03667405
60Central scotoma (HP:0000603)2.02880258
61Labial hypoplasia (HP:0000066)2.01830974
62Dynein arm defect of respiratory motile cilia (HP:0012255)13.7860245
63Absent/shortened dynein arms (HP:0200106)13.7860245
64Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.1013446
65Fibular hypoplasia (HP:0003038)1.99729616
66Cholecystitis (HP:0001082)1.97874908
67Abnormal gallbladder physiology (HP:0012438)1.97874908
68Tubulointerstitial abnormality (HP:0001969)1.96339628
69Limb dystonia (HP:0002451)1.95035565
70Selective tooth agenesis (HP:0001592)1.92769283
71Epileptiform EEG discharges (HP:0011182)1.92302572
72Abnormality of the labia minora (HP:0012880)1.91423623
73Anophthalmia (HP:0000528)1.91106790
74Abnormal rod and cone electroretinograms (HP:0008323)1.90815852
75Broad-based gait (HP:0002136)1.85434928
76EEG with generalized epileptiform discharges (HP:0011198)1.84383153
77Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.82366877
78Amyotrophic lateral sclerosis (HP:0007354)1.82345280
79Absent eyebrow (HP:0002223)1.81856540
80Hypsarrhythmia (HP:0002521)1.78523360
81Poor suck (HP:0002033)1.78109942
82Bilateral microphthalmos (HP:0007633)1.77504683
83Large for gestational age (HP:0001520)1.76437122
84Bifid tongue (HP:0010297)1.76422198
85Preaxial hand polydactyly (HP:0001177)1.76241134
86Abnormal hair whorl (HP:0010721)1.75093360
87Supernumerary spleens (HP:0009799)1.74190361
88Hypoplastic female external genitalia (HP:0012815)1.74139858
89Specific learning disability (HP:0001328)1.73213710
90Growth hormone deficiency (HP:0000824)1.72799985
91Median cleft lip (HP:0000161)1.72429501
92Short foot (HP:0001773)1.72335772
93Volvulus (HP:0002580)1.72170539
94Absent speech (HP:0001344)1.71114998
95Short 1st metacarpal (HP:0010034)1.70894468
96Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.70894468
97Male pseudohermaphroditism (HP:0000037)1.70863494
98Anosmia (HP:0000458)1.69936570
99Short ribs (HP:0000773)1.68691115
100Cupped ear (HP:0000378)1.68394626
101Absent frontal sinuses (HP:0002688)1.67296851
102Azoospermia (HP:0000027)1.67264037
103Thyroid-stimulating hormone excess (HP:0002925)1.66957605
104Aplasia/Hypoplasia of the lens (HP:0008063)1.66452731
105Aplasia/Hypoplasia of the fovea (HP:0008060)1.65385898
106Hypoplasia of the fovea (HP:0007750)1.65385898
107Drooling (HP:0002307)1.64871454
108Tongue fasciculations (HP:0001308)1.64776366
109Hepatoblastoma (HP:0002884)1.63964234
110Agitation (HP:0000713)1.63706204
111Dyschromatopsia (HP:0007641)1.62071141
112Medial flaring of the eyebrow (HP:0010747)1.58861838
113Stage 5 chronic kidney disease (HP:0003774)1.57937449
114Broad distal phalanx of finger (HP:0009836)1.54094019
115Absent epiphyses (HP:0010577)1.53725585
116Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.53725585
117Tubulointerstitial fibrosis (HP:0005576)1.52297691
118Postaxial foot polydactyly (HP:0001830)1.52251147
119Oculomotor apraxia (HP:0000657)1.48139032
120Spastic tetraparesis (HP:0001285)1.47408940
121Facial cleft (HP:0002006)1.44903805
122Abnormality of the dental root (HP:0006486)1.44148113
123Taurodontia (HP:0000679)1.44148113
124Abnormality of permanent molar morphology (HP:0011071)1.44148113
125Aplasia/Hypoplasia of the fibula (HP:0006492)1.41582430
126Abnormality of dentin (HP:0010299)1.40651571
127Heterotopia (HP:0002282)1.40010014
128Breast carcinoma (HP:0003002)1.38546874
129High pitched voice (HP:0001620)1.38457339
13011 pairs of ribs (HP:0000878)1.36403793
131Vascular calcification (HP:0004934)1.34783723
132Abnormality of the renal cortex (HP:0011035)1.32818393
133Eczematoid dermatitis (HP:0000976)1.31244158
134Abnormality of renal excretion (HP:0011036)1.29689108
135Recurrent abscess formation (HP:0002722)1.28894665
136Upper motor neuron abnormality (HP:0002127)1.28472446
137Abnormality of the dental pulp (HP:0006479)1.28079628
138Abnormality of molar morphology (HP:0011070)1.27819099
139Abnormality of molar (HP:0011077)1.27819099
140Abdominal situs inversus (HP:0003363)1.27807485
141Abnormality of abdominal situs (HP:0011620)1.27807485
142Cystic liver disease (HP:0006706)1.27244886
143Decreased central vision (HP:0007663)1.26862104
144Rhabdomyolysis (HP:0003201)1.25435250
145Microglossia (HP:0000171)1.25235785
146Chronic sinusitis (HP:0011109)1.24118300
147Hemorrhage of the eye (HP:0011885)1.23095074
148Sloping forehead (HP:0000340)1.22483997
149Cardiovascular calcification (HP:0011915)1.21942015
150Severe visual impairment (HP:0001141)1.21483601
151Congenital hepatic fibrosis (HP:0002612)1.20338133
152Aplasia/hypoplasia of the humerus (HP:0006507)1.17580207
153Degeneration of anterior horn cells (HP:0002398)1.16837977
154Abnormality of the anterior horn cell (HP:0006802)1.16837977
155Cleft eyelid (HP:0000625)1.16758847
156Short humerus (HP:0005792)1.16161046
157J-shaped sella turcica (HP:0002680)1.14455369
158Nephroblastoma (Wilms tumor) (HP:0002667)1.13584743
159Bile duct proliferation (HP:0001408)1.13448830
160Abnormal biliary tract physiology (HP:0012439)1.13448830
161Long foot (HP:0001833)1.11814453
162Abnormality of macular pigmentation (HP:0008002)1.11810445
163Abnormal drinking behavior (HP:0030082)1.11694606
164Polydipsia (HP:0001959)1.11694606
165Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.11283987
166Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.10906953
167Aplasia/Hypoplasia of the tongue (HP:0010295)1.09429868
168Abnormal lung lobation (HP:0002101)1.08613341
169Myoglobinuria (HP:0002913)1.07908432
170Personality changes (HP:0000751)1.07583918

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.25380741
2PDK48.25380741
3FRK5.33492814
4PDK25.21641450
5TESK15.07525191
6MAP4K23.83590402
7EPHA43.37399429
8PRKD33.04401215
9BMPR1B2.62844970
10MAP3K42.60728971
11WNK32.59019193
12MAPK152.58496967
13NEK22.55799447
14TESK22.50707477
15ICK2.50564698
16TRIM282.49974894
17INSRR2.37339989
18NTRK32.34937996
19WEE12.20078722
20AKT32.13263515
21FGFR22.04969416
22BUB12.00192813
23NEK11.95598243
24CASK1.86862306
25PTK2B1.85679640
26MARK11.74937753
27PHKG11.72180932
28PHKG21.72180932
29TTK1.70283777
30GRK11.68328742
31PNCK1.64343501
32MAP2K71.60871311
33TNIK1.60022324
34MKNK21.59067838
35STK38L1.55421940
36BCR1.55255350
37WNK41.55024360
38PLK21.48210889
39STK391.46754084
40DAPK21.45002564
41MAPK131.40737009
42IRAK21.37464855
43CSNK1G11.35623146
44CSNK1G21.33488659
45DYRK1B1.32381412
46ADRBK21.31859527
47DYRK31.30002597
48CDC71.24432725
49PAK41.23611210
50MKNK11.22542915
51PAK31.15378897
52PASK1.13134598
53CSNK1G31.13026537
54PRKCE1.11314055
55CSNK1A1L1.07186863
56FER1.02988166
57BRD41.00205435
58MAP2K60.95600948
59TGFBR10.95092089
60PLK10.94995339
61ZAK0.93387382
62CHEK20.88958783
63UHMK10.82672180
64TLK10.81714833
65CCNB10.80505450
66PDK10.79422215
67TIE10.79080941
68NLK0.77023556
69DYRK20.76110320
70EPHA30.75517320
71EEF2K0.71951482
72STK160.71782890
73YES10.71433062
74AURKB0.68503543
75STK100.66128259
76STK380.64098373
77CHEK10.63767980
78CDK60.62569199
79PLK40.62272465
80NUAK10.61493704
81PAK10.61324632
82MAP3K80.60891924
83BRAF0.60482244
84MST40.59768363
85AURKA0.58170129
86SGK20.56002064
87MUSK0.54975975
88ATR0.54594847
89CHUK0.51526274
90TYRO30.49963123
91PINK10.49209273
92PRKAA20.48541393
93ADRBK10.47575906
94BRSK20.46522435
95MAP2K40.46200237
96DYRK1A0.46119655
97MINK10.45980291
98PRKAA10.45839489
99TTN0.45414146
100CDK190.44847654
101BRSK10.44282553
102EPHB10.44131786
103TAF10.44111825
104ACVR1B0.44081329
105TSSK60.42978424
106PLK30.42662434
107CDK40.42614099
108OXSR10.42106883
109PRKACA0.41340123
110BLK0.40550896
111ATM0.39989905
112CDK150.39786789
113CSNK1A10.39586874
114MAP3K100.39465935
115STK110.39465655
116CDK120.38315668
117PRKCB0.38089224
118WNK10.38028973
119MAPK40.37993537
120FES0.36792068
121CDK11A0.36397187
122CAMK2A0.36264830
123CDK50.35871213
124CDK180.35673245
125PRKACB0.34922635
126CSNK1E0.34788585
127VRK10.34596033
128CDK140.33732701
129FGR0.33662835
130PDPK10.33635846
131EIF2AK30.32255533
132NTRK20.31710949
133ERBB20.31537064
134LIMK10.31324625
135SGK4940.29437391
136SGK2230.29437391
137MAP2K10.28923519
138STK30.28660382
139PKN10.28328278
140TRPM70.27994865
141CDK70.27516139
142ERBB30.26143234
143RIPK40.25980243
144ROCK10.25716156
145PRKCA0.25618486
146NME10.24831829
147CDK20.24726141
148CLK10.23239712
149CAMKK10.22390057
150EIF2AK10.22276217
151STK40.21757212
152TAOK10.20901098
153CDK10.18484120
154MTOR0.17702930
155RPS6KB10.17573808
156CSNK2A20.17482159
157CSNK2A10.17181682
158LMTK20.16652392
159KDR0.16089679
160PAK20.15814603
161CSK0.14924421
162SRPK10.13279432
163RPS6KA40.13030333
164PRKG10.12764093
165GRK60.12565140
166MARK20.12211450
167PRKG20.11943200
168PIM10.11643711
169PRKDC0.09885523
170IRAK10.09740808
171PRKCG0.08851077
172PRKCD0.07692753
173MAPK80.06604710
174PRKACG0.05856053
175ALK0.05693489
176PAK60.05628136
177PBK0.05471410
178CSNK1D0.05437417
179GSK3B0.05188563

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007505.25548783
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.73014463
3Maturity onset diabetes of the young_Homo sapiens_hsa049504.59791169
4Pyruvate metabolism_Homo sapiens_hsa006203.71933346
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.50637839
6Butanoate metabolism_Homo sapiens_hsa006502.92473768
7Propanoate metabolism_Homo sapiens_hsa006402.89845249
8Fatty acid biosynthesis_Homo sapiens_hsa000612.88494189
9Pentose phosphate pathway_Homo sapiens_hsa000302.67509863
10Glucagon signaling pathway_Homo sapiens_hsa049222.63356318
11Protein export_Homo sapiens_hsa030602.56439884
12Fanconi anemia pathway_Homo sapiens_hsa034602.50717425
13Oocyte meiosis_Homo sapiens_hsa041142.48473925
14DNA replication_Homo sapiens_hsa030302.45009670
15Basal transcription factors_Homo sapiens_hsa030222.30557377
16Selenocompound metabolism_Homo sapiens_hsa004502.09879348
17RNA transport_Homo sapiens_hsa030132.07453297
18Caffeine metabolism_Homo sapiens_hsa002322.05611304
19ABC transporters_Homo sapiens_hsa020102.05466479
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.04269983
21Mismatch repair_Homo sapiens_hsa034301.97660592
22Carbon metabolism_Homo sapiens_hsa012001.93635012
23Phototransduction_Homo sapiens_hsa047441.87065102
24Nicotine addiction_Homo sapiens_hsa050331.82693160
25Primary bile acid biosynthesis_Homo sapiens_hsa001201.80579091
26Cysteine and methionine metabolism_Homo sapiens_hsa002701.78903895
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.74170248
28Cell cycle_Homo sapiens_hsa041101.73148834
29Glycosaminoglycan degradation_Homo sapiens_hsa005311.72486058
30Insulin secretion_Homo sapiens_hsa049111.68084221
31Oxidative phosphorylation_Homo sapiens_hsa001901.67782028
32Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.66008211
33Biosynthesis of amino acids_Homo sapiens_hsa012301.65977113
34Proteasome_Homo sapiens_hsa030501.62619625
35Taste transduction_Homo sapiens_hsa047421.57902059
36alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.57328862
37Linoleic acid metabolism_Homo sapiens_hsa005911.55260230
38Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.54314161
39Tryptophan metabolism_Homo sapiens_hsa003801.54195374
40Spliceosome_Homo sapiens_hsa030401.49476198
41Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.48603796
42Regulation of autophagy_Homo sapiens_hsa041401.40901608
43Olfactory transduction_Homo sapiens_hsa047401.40311122
44mRNA surveillance pathway_Homo sapiens_hsa030151.39471782
45Fructose and mannose metabolism_Homo sapiens_hsa000511.37528956
46Peroxisome_Homo sapiens_hsa041461.35685218
47Homologous recombination_Homo sapiens_hsa034401.35134943
48Circadian entrainment_Homo sapiens_hsa047131.35046621
49PPAR signaling pathway_Homo sapiens_hsa033201.33041577
50Steroid biosynthesis_Homo sapiens_hsa001001.32347462
51Glycerolipid metabolism_Homo sapiens_hsa005611.31825177
52Carbohydrate digestion and absorption_Homo sapiens_hsa049731.29120145
53Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.25592055
54Sulfur metabolism_Homo sapiens_hsa009201.24659690
55Nitrogen metabolism_Homo sapiens_hsa009101.23604020
56Dopaminergic synapse_Homo sapiens_hsa047281.22930267
57Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.22593693
58Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.20426359
59GABAergic synapse_Homo sapiens_hsa047271.19604776
60Systemic lupus erythematosus_Homo sapiens_hsa053221.19353899
61Glutathione metabolism_Homo sapiens_hsa004801.15162878
62Histidine metabolism_Homo sapiens_hsa003401.14383831
63Sphingolipid metabolism_Homo sapiens_hsa006001.13130683
64Cardiac muscle contraction_Homo sapiens_hsa042601.13115746
65beta-Alanine metabolism_Homo sapiens_hsa004101.12461469
66Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.12354355
67Purine metabolism_Homo sapiens_hsa002301.11256453
68Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.10739105
69One carbon pool by folate_Homo sapiens_hsa006701.09740694
70Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.09146880
71Fatty acid degradation_Homo sapiens_hsa000711.08654015
72Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.07625792
73Pyrimidine metabolism_Homo sapiens_hsa002401.06302191
74Glutamatergic synapse_Homo sapiens_hsa047241.06241551
75Phenylalanine metabolism_Homo sapiens_hsa003601.05782034
76Tyrosine metabolism_Homo sapiens_hsa003501.05267049
77Fatty acid elongation_Homo sapiens_hsa000621.04403585
78Arginine and proline metabolism_Homo sapiens_hsa003301.04248103
79Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.01560698
80Huntingtons disease_Homo sapiens_hsa050161.00348503
81Cocaine addiction_Homo sapiens_hsa050300.98650850
82Retinol metabolism_Homo sapiens_hsa008300.97299486
83Serotonergic synapse_Homo sapiens_hsa047260.93965061
84Parkinsons disease_Homo sapiens_hsa050120.92593952
85Amphetamine addiction_Homo sapiens_hsa050310.92495228
86Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.90041841
87Collecting duct acid secretion_Homo sapiens_hsa049660.88971514
88Nucleotide excision repair_Homo sapiens_hsa034200.88958646
89Morphine addiction_Homo sapiens_hsa050320.86039679
90Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.85106586
91Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.84903531
92Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.83840451
93Fat digestion and absorption_Homo sapiens_hsa049750.83459151
94Fatty acid metabolism_Homo sapiens_hsa012120.82767441
95SNARE interactions in vesicular transport_Homo sapiens_hsa041300.82628708
96Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.81359160
97Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.77263889
98Renin secretion_Homo sapiens_hsa049240.75221508
99Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.74548935
100Base excision repair_Homo sapiens_hsa034100.73175410
101Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.72951042
102Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.72208008
103Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.69799066
104Circadian rhythm_Homo sapiens_hsa047100.68780012
105p53 signaling pathway_Homo sapiens_hsa041150.67646780
106Long-term potentiation_Homo sapiens_hsa047200.67491982
107Antigen processing and presentation_Homo sapiens_hsa046120.66571304
108cAMP signaling pathway_Homo sapiens_hsa040240.66061718
109Chemical carcinogenesis_Homo sapiens_hsa052040.65183097
110Alzheimers disease_Homo sapiens_hsa050100.65104771
111Vitamin digestion and absorption_Homo sapiens_hsa049770.64273907
112Arginine biosynthesis_Homo sapiens_hsa002200.62888576
113Dorso-ventral axis formation_Homo sapiens_hsa043200.61815165
114RNA degradation_Homo sapiens_hsa030180.61004507
115Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.59683616
116VEGF signaling pathway_Homo sapiens_hsa043700.59246242
117Epstein-Barr virus infection_Homo sapiens_hsa051690.57733332
118TGF-beta signaling pathway_Homo sapiens_hsa043500.57567396
119Folate biosynthesis_Homo sapiens_hsa007900.57545577
120Central carbon metabolism in cancer_Homo sapiens_hsa052300.57081652
121Calcium signaling pathway_Homo sapiens_hsa040200.55960916
122Viral carcinogenesis_Homo sapiens_hsa052030.55912570
123Type II diabetes mellitus_Homo sapiens_hsa049300.55173794
124Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.54314522
125Non-homologous end-joining_Homo sapiens_hsa034500.52791610
126Wnt signaling pathway_Homo sapiens_hsa043100.52746787
127Alcoholism_Homo sapiens_hsa050340.52491849
128Steroid hormone biosynthesis_Homo sapiens_hsa001400.52305275
129Basal cell carcinoma_Homo sapiens_hsa052170.51904702
130Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.51210536
131Mineral absorption_Homo sapiens_hsa049780.51079428
132Long-term depression_Homo sapiens_hsa047300.50239623
133Ovarian steroidogenesis_Homo sapiens_hsa049130.49314239
134N-Glycan biosynthesis_Homo sapiens_hsa005100.47409768
135Legionellosis_Homo sapiens_hsa051340.47295945
136Tight junction_Homo sapiens_hsa045300.47034382
137Glycerophospholipid metabolism_Homo sapiens_hsa005640.44583036
138Thyroid hormone synthesis_Homo sapiens_hsa049180.42591988
139Pentose and glucuronate interconversions_Homo sapiens_hsa000400.41688718
140Salivary secretion_Homo sapiens_hsa049700.40101454
141Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.38997914
142Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.38291661
143Arachidonic acid metabolism_Homo sapiens_hsa005900.37284707
144Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.37124632
145Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.36493421
146Cyanoamino acid metabolism_Homo sapiens_hsa004600.35302167
147Ether lipid metabolism_Homo sapiens_hsa005650.34250769
148Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.33345958
149Metabolic pathways_Homo sapiens_hsa011000.32165601
150Phagosome_Homo sapiens_hsa041450.28507536
151Hedgehog signaling pathway_Homo sapiens_hsa043400.28461645
152cGMP-PKG signaling pathway_Homo sapiens_hsa040220.28151568
153B cell receptor signaling pathway_Homo sapiens_hsa046620.28031951
154Estrogen signaling pathway_Homo sapiens_hsa049150.27953222
155Adipocytokine signaling pathway_Homo sapiens_hsa049200.26452526
156Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.24549108
157Leukocyte transendothelial migration_Homo sapiens_hsa046700.24155601
158AMPK signaling pathway_Homo sapiens_hsa041520.23518944
159Renin-angiotensin system_Homo sapiens_hsa046140.23205966
160Endocytosis_Homo sapiens_hsa041440.21792784
161HTLV-I infection_Homo sapiens_hsa051660.21555430
162Synaptic vesicle cycle_Homo sapiens_hsa047210.21413938
163Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.20577829
164Shigellosis_Homo sapiens_hsa051310.18589832
165Salmonella infection_Homo sapiens_hsa051320.16377114

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