TCP1P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of action potential (GO:0045760)8.16635415
2fusion of sperm to egg plasma membrane (GO:0007342)7.06275231
3regulation of acrosome reaction (GO:0060046)6.48911760
4plasma membrane fusion (GO:0045026)5.54976441
5DNA deamination (GO:0045006)5.45785791
6regulation of action potential (GO:0098900)5.31638448
7regulation of cell communication by electrical coupling (GO:0010649)5.11263356
8positive regulation of sodium ion transmembrane transporter activity (GO:2000651)5.09195151
9maturation of 5.8S rRNA (GO:0000460)4.96856187
10proteasome assembly (GO:0043248)4.49316367
11water-soluble vitamin biosynthetic process (GO:0042364)4.42369623
12piRNA metabolic process (GO:0034587)4.26265418
13ubiquinone metabolic process (GO:0006743)4.26249237
14positive regulation of sodium ion transmembrane transport (GO:1902307)4.12885721
15rRNA modification (GO:0000154)4.12775831
16protein-cofactor linkage (GO:0018065)4.03647016
17neuronal action potential (GO:0019228)4.01598107
18regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.82758148
19kynurenine metabolic process (GO:0070189)3.79986437
20establishment of protein localization to mitochondrial membrane (GO:0090151)3.76531445
21mitochondrial RNA metabolic process (GO:0000959)3.72272545
22positive regulation of protein targeting to membrane (GO:0090314)3.71554839
23protein deneddylation (GO:0000338)3.70372996
24cullin deneddylation (GO:0010388)3.67644055
25sperm-egg recognition (GO:0035036)3.63927867
26protein polyglutamylation (GO:0018095)3.62476121
27binding of sperm to zona pellucida (GO:0007339)3.60713605
28ubiquinone biosynthetic process (GO:0006744)3.54302848
29tryptophan catabolic process (GO:0006569)3.52393441
30indole-containing compound catabolic process (GO:0042436)3.52393441
31indolalkylamine catabolic process (GO:0046218)3.52393441
32rRNA methylation (GO:0031167)3.48101609
33primary amino compound metabolic process (GO:1901160)3.47549149
34pseudouridine synthesis (GO:0001522)3.36779803
35exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.36451529
36DNA double-strand break processing (GO:0000729)3.35678330
37serotonin metabolic process (GO:0042428)3.35602328
38RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.33828247
39tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.33828247
40epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.33452405
41nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.32238821
42cellular ketone body metabolic process (GO:0046950)3.28770534
43cell-cell recognition (GO:0009988)3.27559907
44behavioral response to nicotine (GO:0035095)3.26331089
45tryptophan metabolic process (GO:0006568)3.18812061
46termination of RNA polymerase III transcription (GO:0006386)3.16275030
47transcription elongation from RNA polymerase III promoter (GO:0006385)3.16275030
48chaperone-mediated protein transport (GO:0072321)3.11254263
49indole-containing compound metabolic process (GO:0042430)3.09207566
50magnesium ion transport (GO:0015693)3.07864360
51cytidine catabolic process (GO:0006216)3.07463565
52cytidine deamination (GO:0009972)3.07463565
53cytidine metabolic process (GO:0046087)3.07463565
54mitochondrial respiratory chain complex assembly (GO:0033108)3.05710627
55protein complex biogenesis (GO:0070271)2.98336278
56neuron cell-cell adhesion (GO:0007158)2.97812130
57L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.94463064
58ATP synthesis coupled proton transport (GO:0015986)2.94378891
59energy coupled proton transport, down electrochemical gradient (GO:0015985)2.94378891
60DNA methylation involved in gamete generation (GO:0043046)2.94260315
61regulation of cilium movement (GO:0003352)2.89891612
62ketone body metabolic process (GO:1902224)2.88136583
63histone H4-K12 acetylation (GO:0043983)2.88007372
64quinone biosynthetic process (GO:1901663)2.87820383
65regulation of cellular amino acid metabolic process (GO:0006521)2.86166062
66RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.83946920
67mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.83041967
68mitochondrial respiratory chain complex I assembly (GO:0032981)2.83041967
69NADH dehydrogenase complex assembly (GO:0010257)2.83041967
70peptidyl-histidine modification (GO:0018202)2.82687457
71carnitine metabolic process (GO:0009437)2.81469134
72indolalkylamine metabolic process (GO:0006586)2.78691072
73regulation of nuclear cell cycle DNA replication (GO:0033262)2.76810439
74tRNA processing (GO:0008033)2.76482736
75negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.75275669
76ribosome assembly (GO:0042255)2.74188222
77fucose catabolic process (GO:0019317)2.73861284
78L-fucose metabolic process (GO:0042354)2.73861284
79L-fucose catabolic process (GO:0042355)2.73861284
80preassembly of GPI anchor in ER membrane (GO:0016254)2.71470911
81mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.68810238
82detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)2.68022222
83detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.67648275
84regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.65315805
85DNA catabolic process, exonucleolytic (GO:0000738)2.63470854
86negative regulation of ligase activity (GO:0051352)2.61765311
87negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.61765311
88behavioral response to ethanol (GO:0048149)2.61665494
89termination of RNA polymerase I transcription (GO:0006363)2.61445337
90sequestering of extracellular ligand from receptor (GO:0035581)2.60532376
91protein peptidyl-prolyl isomerization (GO:0000413)2.59703172
92regulation of calcium ion-dependent exocytosis (GO:0017158)2.59204168
93DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.59080473
94CENP-A containing nucleosome assembly (GO:0034080)2.58782050
95tRNA modification (GO:0006400)2.58101581
96DNA replication-dependent nucleosome assembly (GO:0006335)2.57861132
97DNA replication-dependent nucleosome organization (GO:0034723)2.57861132
98tRNA metabolic process (GO:0006399)2.57628074
99signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.56624390
100signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.56624390

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_22108803_ChIP-Seq_LS180_Human5.08471855
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.61284910
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.35595135
4ZNF274_21170338_ChIP-Seq_K562_Hela3.22732420
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.11916550
6GBX2_23144817_ChIP-Seq_PC3_Human2.86628221
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.81164292
8EZH2_22144423_ChIP-Seq_EOC_Human2.80966825
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.72575504
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.64728411
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.63300418
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.55624487
13PCGF2_27294783_Chip-Seq_NPCs_Mouse2.41574558
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.28712788
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.25424069
16PCGF2_27294783_Chip-Seq_ESCs_Mouse2.22438127
17JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.16946513
18CTBP2_25329375_ChIP-Seq_LNCAP_Human2.14828232
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.11975730
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.08568362
21VDR_23849224_ChIP-Seq_CD4+_Human2.03892619
22IGF1R_20145208_ChIP-Seq_DFB_Human2.02527418
23EWS_26573619_Chip-Seq_HEK293_Human1.91982798
24ETS1_20019798_ChIP-Seq_JURKAT_Human1.88095171
25POU3F2_20337985_ChIP-ChIP_501MEL_Human1.85187625
26CTBP1_25329375_ChIP-Seq_LNCAP_Human1.83549066
27SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.82557664
28FUS_26573619_Chip-Seq_HEK293_Human1.81370924
29ER_23166858_ChIP-Seq_MCF-7_Human1.77028025
30P300_19829295_ChIP-Seq_ESCs_Human1.69725465
31SUZ12_27294783_Chip-Seq_NPCs_Mouse1.66773326
32ELK1_19687146_ChIP-ChIP_HELA_Human1.64331240
33EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.64040284
34CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.54440368
35PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.53873421
36NFE2_27457419_Chip-Seq_LIVER_Mouse1.49852837
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.48818403
38BP1_19119308_ChIP-ChIP_Hs578T_Human1.48267935
39NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.42722718
40NOTCH1_21737748_ChIP-Seq_TLL_Human1.42502762
41TP53_22573176_ChIP-Seq_HFKS_Human1.39915585
42EZH2_27294783_Chip-Seq_NPCs_Mouse1.39695367
43MYC_18940864_ChIP-ChIP_HL60_Human1.35869700
44MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.35003504
45UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.29281039
46GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.28300826
47SRF_21415370_ChIP-Seq_HL-1_Mouse1.26283988
48SALL1_21062744_ChIP-ChIP_HESCs_Human1.25033643
49IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.24389055
50FOXA1_27270436_Chip-Seq_PROSTATE_Human1.22169575
51FOXA1_25329375_ChIP-Seq_VCAP_Human1.22169575
52E2F4_17652178_ChIP-ChIP_JURKAT_Human1.21704085
53AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.19986322
54CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.17506015
55IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.17233127
56CBP_20019798_ChIP-Seq_JUKART_Human1.17233127
57FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.15800258
58NANOG_19829295_ChIP-Seq_ESCs_Human1.15746806
59SOX2_19829295_ChIP-Seq_ESCs_Human1.15746806
60FOXA1_21572438_ChIP-Seq_LNCaP_Human1.14383546
61TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13163580
62NCOR_22424771_ChIP-Seq_293T_Human1.11050769
63CRX_20693478_ChIP-Seq_RETINA_Mouse1.10568702
64CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.10407739
65FOXP3_21729870_ChIP-Seq_TREG_Human1.10171452
66KLF5_20875108_ChIP-Seq_MESCs_Mouse1.09359292
67HOXB7_26014856_ChIP-Seq_BT474_Human1.09238662
68PADI4_21655091_ChIP-ChIP_MCF-7_Human1.06167559
69TCF4_23295773_ChIP-Seq_U87_Human1.05503463
70AR_20517297_ChIP-Seq_VCAP_Human1.05303552
71PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.05228431
72IRF1_19129219_ChIP-ChIP_H3396_Human1.04511848
73CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.04479138
74BMI1_23680149_ChIP-Seq_NPCS_Mouse0.99990194
75BCAT_22108803_ChIP-Seq_LS180_Human0.97148811
76SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.96939808
77AR_25329375_ChIP-Seq_VCAP_Human0.95634950
78STAT3_23295773_ChIP-Seq_U87_Human0.94725725
79FOXH1_21741376_ChIP-Seq_EPCs_Human0.93061027
80YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.92646133
81DCP1A_22483619_ChIP-Seq_HELA_Human0.92482276
82HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.92390169
83GABP_19822575_ChIP-Seq_HepG2_Human0.92350775
84PIAS1_25552417_ChIP-Seq_VCAP_Human0.92304378
85GATA3_21878914_ChIP-Seq_MCF-7_Human0.92224454
86TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.92022907
87EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.91855502
88RUNX2_22187159_ChIP-Seq_PCA_Human0.91216568
89AUTS2_25519132_ChIP-Seq_293T-REX_Human0.90840009
90CREB1_15753290_ChIP-ChIP_HEK293T_Human0.90761471
91PHF8_20622853_ChIP-Seq_HELA_Human0.90439424
92SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.90318067
93P53_22387025_ChIP-Seq_ESCs_Mouse0.89832672
94RNF2_27304074_Chip-Seq_NSC_Mouse0.89484101
95STAT3_18555785_Chip-Seq_ESCs_Mouse0.89434554
96MYC_18555785_ChIP-Seq_MESCs_Mouse0.88453701
97OCT4_21477851_ChIP-Seq_ESCs_Mouse0.87116824
98POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.87054676
99TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87054676
100CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.85130980

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.32070390
2MP0002138_abnormal_hepatobiliary_system3.28921409
3MP0000569_abnormal_digit_pigmentation3.07112159
4MP0003283_abnormal_digestive_organ2.91772699
5MP0009379_abnormal_foot_pigmentation2.87951091
6MP0005646_abnormal_pituitary_gland2.83005732
7MP0004133_heterotaxia2.36276499
8MP0001873_stomach_inflammation2.22043203
9MP0005084_abnormal_gallbladder_morpholo2.20709534
10MP0005085_abnormal_gallbladder_physiolo2.07477836
11MP0006292_abnormal_olfactory_placode2.03006824
12MP0002736_abnormal_nociception_after2.01006566
13MP0002102_abnormal_ear_morphology1.99153255
14MP0009745_abnormal_behavioral_response1.97736685
15MP0001188_hyperpigmentation1.95823612
16MP0002272_abnormal_nervous_system1.92189321
17MP0003646_muscle_fatigue1.90847502
18MP0005174_abnormal_tail_pigmentation1.89798053
19MP0001968_abnormal_touch/_nociception1.89631671
20MP0008058_abnormal_DNA_repair1.75828766
21MP0003806_abnormal_nucleotide_metabolis1.71271214
22MP0006036_abnormal_mitochondrial_physio1.69767919
23MP0000015_abnormal_ear_pigmentation1.66885237
24MP0003195_calcinosis1.65101450
25MP0003693_abnormal_embryo_hatching1.63933257
26MP0001501_abnormal_sleep_pattern1.58960742
27MP0002638_abnormal_pupillary_reflex1.57346496
28MP0008007_abnormal_cellular_replicative1.55736729
29MP0002064_seizures1.54535853
30MP0003787_abnormal_imprinting1.51045614
31MP0003786_premature_aging1.47085033
32MP0002837_dystrophic_cardiac_calcinosis1.44397384
33MP0006035_abnormal_mitochondrial_morpho1.40422064
34MP0005645_abnormal_hypothalamus_physiol1.39375617
35MP0002277_abnormal_respiratory_mucosa1.37887129
36MP0001986_abnormal_taste_sensitivity1.37227174
37MP0008872_abnormal_physiological_respon1.33438157
38MP0001486_abnormal_startle_reflex1.31366566
39MP0005365_abnormal_bile_salt1.30829023
40MP0005187_abnormal_penis_morphology1.29621220
41MP0009046_muscle_twitch1.29117154
42MP0002095_abnormal_skin_pigmentation1.23503766
43MP0004019_abnormal_vitamin_homeostasis1.23174947
44MP0004043_abnormal_pH_regulation1.23011579
45MP0003718_maternal_effect1.22674599
46MP0002733_abnormal_thermal_nociception1.19369211
47MP0004142_abnormal_muscle_tone1.19134191
48MP0002928_abnormal_bile_duct1.18537629
49MP0003137_abnormal_impulse_conducting1.17622554
50MP0008875_abnormal_xenobiotic_pharmacok1.16351563
51MP0001293_anophthalmia1.15640414
52MP0004147_increased_porphyrin_level1.15154065
53MP0001905_abnormal_dopamine_level1.13179996
54MP0002938_white_spotting1.12773698
55MP0004145_abnormal_muscle_electrophysio1.09541476
56MP0005551_abnormal_eye_electrophysiolog1.09234931
57MP0003880_abnormal_central_pattern1.08769653
58MP0000613_abnormal_salivary_gland1.08585516
59MP0009053_abnormal_anal_canal1.08093011
60MP0006276_abnormal_autonomic_nervous1.07714181
61MP0002234_abnormal_pharynx_morphology1.05680293
62MP0006072_abnormal_retinal_apoptosis1.05012868
63MP0002734_abnormal_mechanical_nocicepti1.04771588
64MP0005671_abnormal_response_to1.04181150
65MP0001970_abnormal_pain_threshold1.01481019
66MP0009785_altered_susceptibility_to1.01005422
67MP0003252_abnormal_bile_duct1.00773437
68MP0008961_abnormal_basal_metabolism1.00100135
69MP0008057_abnormal_DNA_replication0.99486704
70MP0005636_abnormal_mineral_homeostasis0.95217211
71MP0003119_abnormal_digestive_system0.94995249
72MP0001529_abnormal_vocalization0.92548929
73MP0002653_abnormal_ependyma_morphology0.92151372
74MP0002210_abnormal_sex_determination0.91707816
75MP0002876_abnormal_thyroid_physiology0.91458343
76MP0002006_tumorigenesis0.89603190
77MP0005389_reproductive_system_phenotype0.87924813
78MP0001765_abnormal_ion_homeostasis0.87171255
79MP0001929_abnormal_gametogenesis0.85138223
80MP0006054_spinal_hemorrhage0.83409362
81MP0002160_abnormal_reproductive_system0.82802387
82MP0004215_abnormal_myocardial_fiber0.82756913
83MP0008995_early_reproductive_senescence0.81968062
84MP0002751_abnormal_autonomic_nervous0.80858113
85MP0005332_abnormal_amino_acid0.80788333
86MP0001440_abnormal_grooming_behavior0.80330909
87MP0001919_abnormal_reproductive_system0.80167313
88MP0010094_abnormal_chromosome_stability0.79212694
89MP0000538_abnormal_urinary_bladder0.79194567
90MP0009643_abnormal_urine_homeostasis0.79131796
91MP0003698_abnormal_male_reproductive0.78734550
92MP0000653_abnormal_sex_gland0.76779313
93MP0004885_abnormal_endolymph0.76612626
94MP0002572_abnormal_emotion/affect_behav0.76186576
95MP0000685_abnormal_immune_system0.76014401
96MP0005423_abnormal_somatic_nervous0.75213997
97MP0000647_abnormal_sebaceous_gland0.73921703
98MP0002166_altered_tumor_susceptibility0.73709854
99MP0003011_delayed_dark_adaptation0.73574575
100MP0001485_abnormal_pinna_reflex0.73184965

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.83313008
2Abnormality of midbrain morphology (HP:0002418)3.95640636
3Molar tooth sign on MRI (HP:0002419)3.95640636
4Acute necrotizing encephalopathy (HP:0006965)3.95589069
5Acute encephalopathy (HP:0006846)3.57828355
6Progressive inability to walk (HP:0002505)3.42383125
7Congenital, generalized hypertrichosis (HP:0004540)3.39489621
8Pancreatic fibrosis (HP:0100732)3.37771122
9Azoospermia (HP:0000027)3.34486967
10Progressive macrocephaly (HP:0004481)3.32979091
11Increased CSF lactate (HP:0002490)3.32804295
12True hermaphroditism (HP:0010459)3.30607433
13Abnormal mitochondria in muscle tissue (HP:0008316)3.17937912
14Absent/shortened dynein arms (HP:0200106)3.10686508
15Dynein arm defect of respiratory motile cilia (HP:0012255)3.10686508
16Mitochondrial inheritance (HP:0001427)3.09328920
17Pendular nystagmus (HP:0012043)3.00826022
18Increased hepatocellular lipid droplets (HP:0006565)2.97230393
19Large for gestational age (HP:0001520)2.97122826
20Bile duct proliferation (HP:0001408)2.88520671
21Abnormal biliary tract physiology (HP:0012439)2.88520671
22Nephronophthisis (HP:0000090)2.75565393
23Abnormal spermatogenesis (HP:0008669)2.74605539
24Cerebral edema (HP:0002181)2.67317914
25Lipid accumulation in hepatocytes (HP:0006561)2.66424151
26Abnormality of secondary sexual hair (HP:0009888)2.62210268
27Abnormality of the axillary hair (HP:0100134)2.62210268
28Abnormal drinking behavior (HP:0030082)2.61591885
29Polydipsia (HP:0001959)2.61591885
30Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.61249832
31Pancytopenia (HP:0001876)2.59725614
32Methylmalonic acidemia (HP:0002912)2.56712339
33Increased serum lactate (HP:0002151)2.53674336
34Abolished electroretinogram (ERG) (HP:0000550)2.49310163
35Renal Fanconi syndrome (HP:0001994)2.47244071
36Inability to walk (HP:0002540)2.45162008
37Supernumerary spleens (HP:0009799)2.38549582
38Sclerocornea (HP:0000647)2.37211854
39Furrowed tongue (HP:0000221)2.34918090
40Cystic liver disease (HP:0006706)2.34177840
41Abnormal rod and cone electroretinograms (HP:0008323)2.30718814
42Hepatocellular necrosis (HP:0001404)2.29861756
43Keratoconus (HP:0000563)2.29500064
44Increased corneal curvature (HP:0100692)2.29500064
45Abnormality of alanine metabolism (HP:0010916)2.27923959
46Hyperalaninemia (HP:0003348)2.27923959
47Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.27923959
48Lethargy (HP:0001254)2.22144694
49Abnormality of the renal medulla (HP:0100957)2.20795999
50Abnormality of the pons (HP:0007361)2.11050109
51Attenuation of retinal blood vessels (HP:0007843)2.10808133
52Testicular atrophy (HP:0000029)2.10046797
53Male pseudohermaphroditism (HP:0000037)2.08886770
54Polyuria (HP:0000103)2.08118240
55Absent rod-and cone-mediated responses on ERG (HP:0007688)2.06596832
56IgG deficiency (HP:0004315)2.06278612
57Abnormality of the renal cortex (HP:0011035)2.05665714
58Abnormality of the ileum (HP:0001549)2.05375405
59Methylmalonic aciduria (HP:0012120)2.03510172
60Enlarged epiphyses (HP:0010580)2.02944181
61Anencephaly (HP:0002323)2.02251523
62Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.01517677
63Meckel diverticulum (HP:0002245)2.01203419
64Abnormal respiratory motile cilium physiology (HP:0012261)1.99292545
65Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.98947451
66Optic disc pallor (HP:0000543)1.98313243
67Focal motor seizures (HP:0011153)1.97175427
68Congenital stationary night blindness (HP:0007642)1.97030594
69Chronic bronchitis (HP:0004469)1.96472963
70Posterior subcapsular cataract (HP:0007787)1.92087469
71Lactic acidosis (HP:0003128)1.91389490
72Autoimmune hemolytic anemia (HP:0001890)1.90939219
73Hepatic necrosis (HP:0002605)1.90630108
74Aplasia/Hypoplasia of the uvula (HP:0010293)1.88564171
75Abnormality of aspartate family amino acid metabolism (HP:0010899)1.87462639
76Aplasia/Hypoplasia of the tibia (HP:0005772)1.86854164
77Delayed CNS myelination (HP:0002188)1.86770619
78Hypoproteinemia (HP:0003075)1.86315810
79Abnormality of renal resorption (HP:0011038)1.86155106
80Congenital hepatic fibrosis (HP:0002612)1.83865074
81Aplasia/Hypoplasia of the tongue (HP:0010295)1.83110146
82Abnormal respiratory motile cilium morphology (HP:0005938)1.81446675
83Abnormal respiratory epithelium morphology (HP:0012253)1.81446675
84Postaxial foot polydactyly (HP:0001830)1.81157581
85Aplasia/Hypoplasia involving the musculature (HP:0001460)1.79853101
86Palpitations (HP:0001962)1.77908566
87Hyperglycinuria (HP:0003108)1.76449671
88Type II lissencephaly (HP:0007260)1.75326708
89Aplastic anemia (HP:0001915)1.72528400
90Medial flaring of the eyebrow (HP:0010747)1.72435100
91Abnormality of B cell number (HP:0010975)1.71964628
92Abnormal ciliary motility (HP:0012262)1.71213522
93Abnormality of the costochondral junction (HP:0000919)1.69978924
94Type 2 muscle fiber atrophy (HP:0003554)1.68452563
95Leukodystrophy (HP:0002415)1.68241288
96Bilateral microphthalmos (HP:0007633)1.65740958
97Palpebral edema (HP:0100540)1.64859902
98Hypoplasia of the pons (HP:0012110)1.64398694
99Abnormal urine output (HP:0012590)1.63274515
1003-Methylglutaconic aciduria (HP:0003535)1.62798992

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NUAK14.59891530
2FRK3.95336305
3EIF2AK33.03931726
4SIK23.01690538
5TRIM282.95471189
6ZAK2.87054763
7PINK12.80401771
8TSSK62.62516007
9EIF2AK12.36953299
10PDK22.33550623
11PASK2.30458971
12MKNK22.20300798
13WNK42.00957359
14SRPK11.82302823
15PNCK1.78061938
16MKNK11.73812478
17TLK11.70059233
18VRK21.67379720
19MST41.66243198
20ADRBK21.64632224
21MAP4K21.60885734
22STK391.56760747
23STK161.54908931
24BUB11.54495327
25OXSR11.54383599
26DMPK1.51726192
27NTRK31.40023760
28INSRR1.39930753
29GRK11.38397521
30TXK1.37896524
31BCR1.37532032
32MAPKAPK31.27084895
33PLK31.26419085
34WNK31.16677341
35VRK11.09304400
36CDC71.03007253
37PIK3CG1.02640442
38TNIK0.98236392
39BCKDK0.97408154
40MINK10.92590555
41PLK10.91565853
42NEK10.89173881
43PLK20.87679987
44EIF2AK20.86006593
45TEC0.85849299
46TAOK30.81724970
47RPS6KA50.78078694
48MAPK130.77745100
49CASK0.75862184
50TYRO30.73907862
51ACVR1B0.70798402
52CHEK20.70742794
53PLK40.70650526
54TIE10.69462667
55BMPR1B0.67824118
56PHKG10.66615850
57PHKG20.66615850
58DYRK20.66007466
59TTK0.65820991
60MAPKAPK50.65382912
61CSNK1G30.65374254
62ATR0.63268840
63MAP3K90.62651629
64CSNK1G20.60685989
65ITK0.58618891
66RAF10.57438098
67DAPK20.57405728
68ILK0.55923860
69PRKCG0.54124278
70ADRBK10.52527132
71WEE10.52184973
72PRKCQ0.51718275
73ALK0.50596084
74CSNK1G10.49847922
75NME10.49823529
76MAP2K60.48658561
77TGFBR10.46959039
78SIK30.46006513
79IKBKB0.45082534
80RPS6KA40.40963965
81CSNK1A1L0.40214586
82CSNK1A10.39521532
83CCNB10.37691625
84DAPK10.36274820
85MAPK110.35442322
86OBSCN0.35397976
87PRKACA0.34818598
88CSNK2A10.34684839
89STK38L0.32278271
90CAMK2A0.31154365
91ATM0.29575406
92KIT0.28412209
93PRKCE0.28038700
94NEK60.27786167
95PRKCA0.26636469
96STK30.25985504
97LATS10.25868866
98NME20.25416758
99PRKCI0.25295144
100MAP3K40.25161047

Predicted pathways (KEGG)

RankGene SetZ-score
1Selenocompound metabolism_Homo sapiens_hsa004504.10241883
2Proteasome_Homo sapiens_hsa030503.99818534
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.21459586
4Asthma_Homo sapiens_hsa053102.63647326
5Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.33750628
6Oxidative phosphorylation_Homo sapiens_hsa001902.29947627
7RNA polymerase_Homo sapiens_hsa030202.29807292
8Protein export_Homo sapiens_hsa030602.10379192
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.03139783
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.01430106
11Parkinsons disease_Homo sapiens_hsa050121.94802940
12Linoleic acid metabolism_Homo sapiens_hsa005911.84779757
13Homologous recombination_Homo sapiens_hsa034401.79478312
14alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.76999110
15Intestinal immune network for IgA production_Homo sapiens_hsa046721.73729847
16Tryptophan metabolism_Homo sapiens_hsa003801.73531332
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.70645714
18Allograft rejection_Homo sapiens_hsa053301.63095997
19RNA degradation_Homo sapiens_hsa030181.62780958
20Autoimmune thyroid disease_Homo sapiens_hsa053201.62223465
21Butanoate metabolism_Homo sapiens_hsa006501.60280619
22Basal transcription factors_Homo sapiens_hsa030221.55255908
23Type I diabetes mellitus_Homo sapiens_hsa049401.53519480
24RNA transport_Homo sapiens_hsa030131.48304706
25Propanoate metabolism_Homo sapiens_hsa006401.47605403
26Graft-versus-host disease_Homo sapiens_hsa053321.41256957
27Huntingtons disease_Homo sapiens_hsa050161.38178571
28Pyrimidine metabolism_Homo sapiens_hsa002401.33320095
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.32091348
30One carbon pool by folate_Homo sapiens_hsa006701.31956466
31Alzheimers disease_Homo sapiens_hsa050101.26651322
32Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.23549321
33Nicotine addiction_Homo sapiens_hsa050331.22577410
34Fanconi anemia pathway_Homo sapiens_hsa034601.20181171
35Nitrogen metabolism_Homo sapiens_hsa009101.20023110
36Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.18890566
37Purine metabolism_Homo sapiens_hsa002301.17977729
38Phototransduction_Homo sapiens_hsa047441.13439357
39Taste transduction_Homo sapiens_hsa047421.10364180
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.08601093
41Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.06663877
42Fatty acid degradation_Homo sapiens_hsa000711.06389621
43Nucleotide excision repair_Homo sapiens_hsa034201.04409851
44Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.98386818
45Ether lipid metabolism_Homo sapiens_hsa005650.98156072
46Primary immunodeficiency_Homo sapiens_hsa053400.97271803
47Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.96928408
48Antigen processing and presentation_Homo sapiens_hsa046120.96889488
49Rheumatoid arthritis_Homo sapiens_hsa053230.90967187
50DNA replication_Homo sapiens_hsa030300.89516507
51Primary bile acid biosynthesis_Homo sapiens_hsa001200.88249365
52Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.84982750
53Olfactory transduction_Homo sapiens_hsa047400.83947897
54Pyruvate metabolism_Homo sapiens_hsa006200.81641638
55Ribosome_Homo sapiens_hsa030100.81304487
56Spliceosome_Homo sapiens_hsa030400.80350631
57Pentose and glucuronate interconversions_Homo sapiens_hsa000400.79103643
58Cardiac muscle contraction_Homo sapiens_hsa042600.78355645
59Sulfur metabolism_Homo sapiens_hsa009200.77394387
60Caffeine metabolism_Homo sapiens_hsa002320.77165184
61Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.76701544
62Peroxisome_Homo sapiens_hsa041460.76246697
63Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.74522632
64Mismatch repair_Homo sapiens_hsa034300.73535231
65Arachidonic acid metabolism_Homo sapiens_hsa005900.72386064
66beta-Alanine metabolism_Homo sapiens_hsa004100.71738959
67Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.71717580
68Maturity onset diabetes of the young_Homo sapiens_hsa049500.69201568
69Steroid hormone biosynthesis_Homo sapiens_hsa001400.68510858
70Cysteine and methionine metabolism_Homo sapiens_hsa002700.68044378
71Fatty acid metabolism_Homo sapiens_hsa012120.66463121
72Metabolic pathways_Homo sapiens_hsa011000.65121286
73Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.64770269
74Morphine addiction_Homo sapiens_hsa050320.63162108
75SNARE interactions in vesicular transport_Homo sapiens_hsa041300.62454850
76Collecting duct acid secretion_Homo sapiens_hsa049660.62117160
77Circadian entrainment_Homo sapiens_hsa047130.60330838
78Non-homologous end-joining_Homo sapiens_hsa034500.59900470
79ABC transporters_Homo sapiens_hsa020100.58280024
80Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.57969884
81Fat digestion and absorption_Homo sapiens_hsa049750.57328892
82Chemical carcinogenesis_Homo sapiens_hsa052040.57168034
83Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.53110842
84Retinol metabolism_Homo sapiens_hsa008300.52277559
85Epstein-Barr virus infection_Homo sapiens_hsa051690.47225718
86Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.46591361
87Hematopoietic cell lineage_Homo sapiens_hsa046400.43245425
88Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.42728812
89Gastric acid secretion_Homo sapiens_hsa049710.42160912
90Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40807715
91Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.40804908
92Drug metabolism - other enzymes_Homo sapiens_hsa009830.36949412
93Glycerolipid metabolism_Homo sapiens_hsa005610.36719022
94Systemic lupus erythematosus_Homo sapiens_hsa053220.36457946
95Vitamin B6 metabolism_Homo sapiens_hsa007500.35758201
96Viral myocarditis_Homo sapiens_hsa054160.34930424
97GABAergic synapse_Homo sapiens_hsa047270.34852970
98Salivary secretion_Homo sapiens_hsa049700.32502956
99Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.32097553
100Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.31617052

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