TCTA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)4.52123125
2COPI coating of Golgi vesicle (GO:0048205)4.52123125
3signal peptide processing (GO:0006465)3.96064110
4ER overload response (GO:0006983)3.44383161
5fatty acid elongation (GO:0030497)3.38267685
6mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.33017472
7axon ensheathment in central nervous system (GO:0032291)3.20945379
8central nervous system myelination (GO:0022010)3.20945379
9protein maturation by protein folding (GO:0022417)3.16626979
10xenobiotic catabolic process (GO:0042178)3.16307063
11peptide hormone processing (GO:0016486)3.16286054
12COPII vesicle coating (GO:0048208)3.15247086
13regulation of integrin-mediated signaling pathway (GO:2001044)3.14846531
14nucleotide transmembrane transport (GO:1901679)3.08233434
15regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.03290436
16regulation of podosome assembly (GO:0071801)3.02107668
17autophagic vacuole fusion (GO:0000046)3.00316098
18toxin metabolic process (GO:0009404)3.00291074
19retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.97903278
20detection of calcium ion (GO:0005513)2.91347855
21endocrine pancreas development (GO:0031018)2.85780698
22maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.83718515
23ketone body metabolic process (GO:1902224)2.83218909
24neutrophil activation involved in immune response (GO:0002283)2.82419736
25beta-amyloid metabolic process (GO:0050435)2.81956774
26negative regulation of interleukin-17 production (GO:0032700)2.77403351
27nucleoside diphosphate catabolic process (GO:0009134)2.76304923
28respiratory electron transport chain (GO:0022904)2.72891353
29regulation of type B pancreatic cell apoptotic process (GO:2000674)2.72063488
30electron transport chain (GO:0022900)2.71136395
31positive regulation of receptor recycling (GO:0001921)2.70074305
32cholesterol biosynthetic process (GO:0006695)2.69103155
33mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.68068652
34energy coupled proton transport, down electrochemical gradient (GO:0015985)2.62933354
35ATP synthesis coupled proton transport (GO:0015986)2.62933354
36organelle membrane fusion (GO:0090174)2.61159443
37protein retention in ER lumen (GO:0006621)2.61077281
38negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.60914468
39long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.58541236
40response to redox state (GO:0051775)2.56851626
41L-phenylalanine catabolic process (GO:0006559)2.56850160
42erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.56850160
43positive regulation of chemokine biosynthetic process (GO:0045080)2.55696257
44regulation of autophagic vacuole assembly (GO:2000785)2.55693644
45substantia nigra development (GO:0021762)2.53606412
46eye photoreceptor cell differentiation (GO:0001754)2.53160603
47photoreceptor cell differentiation (GO:0046530)2.53160603
48regulation of receptor recycling (GO:0001919)2.52094054
49thrombin receptor signaling pathway (GO:0070493)2.48149852
50fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.47997437
51antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.46617425
52response to gravity (GO:0009629)2.44264808
53dopamine biosynthetic process (GO:0042416)2.43583727
54insulin secretion (GO:0030073)2.41819792
55ATP hydrolysis coupled proton transport (GO:0015991)2.41545022
56energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.41545022
57sterol biosynthetic process (GO:0016126)2.41083635
58ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.40748492
59creatine metabolic process (GO:0006600)2.40177141
60fatty-acyl-CoA biosynthetic process (GO:0046949)2.39764828
61angiogenesis involved in wound healing (GO:0060055)2.37863000
62thioester biosynthetic process (GO:0035384)2.37401930
63acyl-CoA biosynthetic process (GO:0071616)2.37401930
64positive regulation of macrophage derived foam cell differentiation (GO:0010744)2.37388277
65regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.35996779
66antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.35506998
67sequestering of metal ion (GO:0051238)2.35203870
68ER to Golgi vesicle-mediated transport (GO:0006888)2.34941741
69GDP-mannose metabolic process (GO:0019673)2.34774161
70fatty-acyl-CoA metabolic process (GO:0035337)2.33917217
71long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.33688592
72calcium-mediated signaling using intracellular calcium source (GO:0035584)2.33170387
73regulation of cilium movement (GO:0003352)2.33093335
74magnesium ion transport (GO:0015693)2.32279346
75regulation of cholesterol esterification (GO:0010872)2.31924474
76peroxisome fission (GO:0016559)2.31435202
77phenol-containing compound catabolic process (GO:0019336)2.30381387
78negative regulation of JUN kinase activity (GO:0043508)2.29703061
79negative regulation of neurological system process (GO:0031645)2.29505861
80positive regulation of insulin secretion (GO:0032024)2.29406869
81intra-Golgi vesicle-mediated transport (GO:0006891)2.27842141
82negative regulation of neurotransmitter secretion (GO:0046929)2.27794604
83glandular epithelial cell differentiation (GO:0002067)2.26711743
84regulation of regulatory T cell differentiation (GO:0045589)2.26541047
85regulation of amyloid precursor protein catabolic process (GO:1902991)2.26036893
86L-phenylalanine metabolic process (GO:0006558)2.23562680
87erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.23562680
88antigen processing and presentation of endogenous antigen (GO:0019883)2.23496006
89regulation of oxidative phosphorylation (GO:0002082)2.22362826
90positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.22213503
91endosome to pigment granule transport (GO:0043485)2.22203819
92endosome to melanosome transport (GO:0035646)2.22203819
93transferrin transport (GO:0033572)2.22038492
94regulation of insulin secretion (GO:0050796)2.21897232
95response to dietary excess (GO:0002021)2.21707931
96macroautophagy (GO:0016236)2.21654513
97regulation of chemokine biosynthetic process (GO:0045073)2.20220334
98peptide catabolic process (GO:0043171)2.20152283
99regulation of extracellular matrix disassembly (GO:0010715)2.20106366
100regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.19624751
101negative regulation of neurotransmitter transport (GO:0051589)2.19211780
102cellular response to glucagon stimulus (GO:0071377)2.19043581
103positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.18986922
104trivalent inorganic cation transport (GO:0072512)2.18397336
105ferric iron transport (GO:0015682)2.18397336
106peptidyl-tyrosine autophosphorylation (GO:0038083)2.17890540
107phagosome maturation (GO:0090382)2.17047843
108tonic smooth muscle contraction (GO:0014820)2.14649023
109positive regulation of isotype switching (GO:0045830)2.14178093
110regulation of vacuole organization (GO:0044088)2.14003624
111mitochondrial calcium ion transport (GO:0006851)2.13621082
112positive regulation of steroid metabolic process (GO:0045940)2.13532382
113extracellular fibril organization (GO:0043206)2.13223951
114protein complex biogenesis (GO:0070271)2.13202368
115fucose metabolic process (GO:0006004)2.13076277
116positive regulation of action potential (GO:0045760)2.12592338
117protein localization to Golgi apparatus (GO:0034067)2.12455067
118vesicle coating (GO:0006901)2.11928909
119negative regulation of calcium ion transmembrane transport (GO:1903170)2.11812550
120negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.11812550
121regulation of glucocorticoid secretion (GO:2000849)2.11630369
122amyloid precursor protein catabolic process (GO:0042987)2.11116364
1233-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.11099999
124purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.11099999
125positive regulation of DNA recombination (GO:0045911)2.10679981
126regulation of macrophage derived foam cell differentiation (GO:0010743)2.10031885
127protein neddylation (GO:0045116)2.10030206
128regulation of synaptic vesicle exocytosis (GO:2000300)2.09242126
129negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.08572554
130mitochondrial calcium ion homeostasis (GO:0051560)2.08295435
131peptide metabolic process (GO:0006518)2.07263101
132myelination (GO:0042552)2.06869028
133positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.06842221
134plasma membrane fusion (GO:0045026)2.06753413
135calcium ion-dependent exocytosis (GO:0017156)2.06749574
136response to methylmercury (GO:0051597)2.06601923
137regulation of interleukin-6 biosynthetic process (GO:0045408)2.05288044
138axon ensheathment (GO:0008366)2.05191039
139ensheathment of neurons (GO:0007272)2.05191039
140hydrogen ion transmembrane transport (GO:1902600)2.04842945
141long-chain fatty acid biosynthetic process (GO:0042759)2.04742681
142very long-chain fatty acid metabolic process (GO:0000038)2.03840566
143aldehyde catabolic process (GO:0046185)2.03745311
144mannosylation (GO:0097502)2.03560840
145negative regulation of humoral immune response (GO:0002921)2.03510005
146regulation of peptide hormone secretion (GO:0090276)2.03118943
147cellular ketone body metabolic process (GO:0046950)2.02855447
148amyloid precursor protein metabolic process (GO:0042982)2.02665917
149regulation of catecholamine metabolic process (GO:0042069)2.01948797
150regulation of dopamine metabolic process (GO:0042053)2.01948797
151regulation of metalloenzyme activity (GO:0048552)1.99856882
152regulation of platelet aggregation (GO:0090330)1.98767964
153negative regulation of glycoprotein biosynthetic process (GO:0010561)1.98344540
154blood coagulation, intrinsic pathway (GO:0007597)1.98083681
155lipoxygenase pathway (GO:0019372)1.97679207
156regulation of MHC class II biosynthetic process (GO:0045346)1.97532906
157glycerophospholipid catabolic process (GO:0046475)1.97415091
158L-ascorbic acid metabolic process (GO:0019852)1.97049423
159negative regulation of leukocyte mediated cytotoxicity (GO:0001911)1.96831133
160negative regulation of cell killing (GO:0031342)1.96831133
161regulation of lipoprotein metabolic process (GO:0050746)1.96543763
162negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)1.96459261
163fibril organization (GO:0097435)1.96306171
164negative regulation of glycoprotein metabolic process (GO:1903019)1.95811735
165positive regulation of granulocyte differentiation (GO:0030854)1.95611939
166artery smooth muscle contraction (GO:0014824)1.95452980
167antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)1.95124638
168positive regulation of steroid biosynthetic process (GO:0010893)1.94822974
169negative regulation of nitric oxide biosynthetic process (GO:0045019)1.94427246
170cellular response to leptin stimulus (GO:0044320)1.94127352
171low-density lipoprotein particle remodeling (GO:0034374)1.93543929
172platelet aggregation (GO:0070527)1.92753495
173endoplasmic reticulum calcium ion homeostasis (GO:0032469)1.92358237
174monoamine transport (GO:0015844)1.92212975
175positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)1.91716642
176branched-chain amino acid catabolic process (GO:0009083)1.91190340
177negative regulation of protein localization to plasma membrane (GO:1903077)1.90220908
178regulation of memory T cell differentiation (GO:0043380)1.89720122
179response to interferon-beta (GO:0035456)1.89339490
180inositol phosphate catabolic process (GO:0071545)1.88979925
181positive regulation of actin filament depolymerization (GO:0030836)1.88876461
182phosphorylated carbohydrate dephosphorylation (GO:0046838)1.88053350

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human3.73947761
2LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.74362140
3GBX2_23144817_ChIP-Seq_PC3_Human2.73459634
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.60203575
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.59412941
6RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.44207273
7LMO2_20887958_ChIP-Seq_HPC-7_Mouse2.28390503
8IRF8_21731497_ChIP-ChIP_J774_Mouse2.15424066
9TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.14946465
10EZH2_22144423_ChIP-Seq_EOC_Human2.13227447
11VDR_22108803_ChIP-Seq_LS180_Human2.11434517
12SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.97332819
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.96230856
14IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.93241007
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.91162170
16PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.88794439
17GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.85762291
18GATA2_21666600_ChIP-Seq_HMVEC_Human1.85578493
19SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.84682106
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.81516152
21SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.73789987
22BP1_19119308_ChIP-ChIP_Hs578T_Human1.73177226
23MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.72918819
24MTF2_20144788_ChIP-Seq_MESCs_Mouse1.72620809
25CDX2_19796622_ChIP-Seq_MESCs_Mouse1.68934392
26EGR1_23403033_ChIP-Seq_LIVER_Mouse1.68457353
27NR3C1_23031785_ChIP-Seq_PC12_Mouse1.67492454
28NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.62992372
29Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.62788260
30STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.61852573
31STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.60905680
32PPARA_22158963_ChIP-Seq_LIVER_Mouse1.60316711
33TAF15_26573619_Chip-Seq_HEK293_Human1.57755334
34JARID2_20075857_ChIP-Seq_MESCs_Mouse1.56464277
35STAT1_20625510_ChIP-Seq_HELA_Human1.56276091
36SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.55310652
37NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.54659593
38EZH2_27304074_Chip-Seq_ESCs_Mouse1.54403066
39SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.53867821
40EZH2_27294783_Chip-Seq_ESCs_Mouse1.53170190
41SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.53108831
42IKZF1_21737484_ChIP-ChIP_HCT116_Human1.52455016
43EED_16625203_ChIP-ChIP_MESCs_Mouse1.51575620
44SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.51078960
45GATA1_19941827_ChIP-Seq_MEL_Mouse1.50882174
46REST_21632747_ChIP-Seq_MESCs_Mouse1.49064920
47SUZ12_27294783_Chip-Seq_ESCs_Mouse1.46235744
48IRF8_27001747_Chip-Seq_BMDM_Mouse1.45753392
49GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.43996507
50IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.43731620
51EP300_21415370_ChIP-Seq_HL-1_Mouse1.42835891
52GATA1_19941826_ChIP-Seq_K562_Human1.40396324
53JARID2_20064375_ChIP-Seq_MESCs_Mouse1.40242331
54ZFP57_27257070_Chip-Seq_ESCs_Mouse1.40215134
55TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.38614139
56TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38161976
57SPI1_23127762_ChIP-Seq_K562_Human1.37952068
58PIAS1_25552417_ChIP-Seq_VCAP_Human1.37538989
59POU3F2_20337985_ChIP-ChIP_501MEL_Human1.36553535
60BMI1_23680149_ChIP-Seq_NPCS_Mouse1.36107997
61OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34827054
62FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.33001269
63GATA1_22025678_ChIP-Seq_K562_Human1.32737186
64ELF1_17652178_ChIP-ChIP_JURKAT_Human1.31196346
65NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.30953996
66NRF2_20460467_ChIP-Seq_MEFs_Mouse1.30953996
67CTBP2_25329375_ChIP-Seq_LNCAP_Human1.29758218
68TRIM28_21343339_ChIP-Seq_HEK293_Human1.29685860
69PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.29449278
70RNF2_18974828_ChIP-Seq_MESCs_Mouse1.28699718
71EZH2_18974828_ChIP-Seq_MESCs_Mouse1.28699718
72RUNX1_22412390_ChIP-Seq_EML_Mouse1.28301580
73REST_18959480_ChIP-ChIP_MESCs_Mouse1.28140883
74SCL_19346495_ChIP-Seq_HPC-7_Human1.26895808
75* ELF1_20517297_ChIP-Seq_JURKAT_Human1.26811519
76FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.26123497
77CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.25080222
78DROSHA_22980978_ChIP-Seq_HELA_Human1.21960580
79RARG_19884340_ChIP-ChIP_MEFs_Mouse1.20702190
80PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.20447105
81ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.20175993
82DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.19674014
83CTBP1_25329375_ChIP-Seq_LNCAP_Human1.19069382
84SRF_21415370_ChIP-Seq_HL-1_Mouse1.18371016
85ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.17458123
86THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.17153252
87TOP2B_26459242_ChIP-Seq_MCF-7_Human1.16896966
88BCOR_27268052_Chip-Seq_Bcells_Human1.16614736
89SMAD4_21799915_ChIP-Seq_A2780_Human1.12966383
90BCL6_27268052_Chip-Seq_Bcells_Human1.12820522
91GATA2_19941826_ChIP-Seq_K562_Human1.11480343
92GATA1_22383799_ChIP-Seq_G1ME_Mouse1.08781870
93RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.08183866
94PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.06499632
95WT1_19549856_ChIP-ChIP_CCG9911_Human1.06239685
96P300_19829295_ChIP-Seq_ESCs_Human1.06118449
97E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.06061313
98SPI1_23547873_ChIP-Seq_NB4_Human1.04806961
99RUNX_20019798_ChIP-Seq_JUKART_Human1.03788836
100RAD21_21589869_ChIP-Seq_MESCs_Mouse1.03614270
101JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02530661
102RNF2_27304074_Chip-Seq_ESCs_Mouse1.02449798
103CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02369268
104JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01819902
105P300_27268052_Chip-Seq_Bcells_Human1.01586561
106PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01350357
107LXR_22158963_ChIP-Seq_LIVER_Mouse0.99844966
108CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99689308
109NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.99041480
110CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.98631775
111PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.98466382
112ER_23166858_ChIP-Seq_MCF-7_Human0.98233232
113PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98193804
114MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98086407
115PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97918657
116SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.97382973
117ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.97220438
118RXR_22158963_ChIP-Seq_LIVER_Mouse0.96146851
119STAT4_19710469_ChIP-ChIP_TH1__Mouse0.95361726
120HTT_18923047_ChIP-ChIP_STHdh_Human0.94783272
121VDR_24763502_ChIP-Seq_THP-1_Human0.94756969
122ZNF274_21170338_ChIP-Seq_K562_Hela0.94618226
123SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94450870
124LXR_22292898_ChIP-Seq_THP-1_Human0.93730866
125AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.93684856
126TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93366345
127OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.93077211
128ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.92779571
129PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.92376649
130EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.91886667
131FLI1_21867929_ChIP-Seq_TH2_Mouse0.91853568
132SOX2_21211035_ChIP-Seq_LN229_Gbm0.91197484
133SMAD_19615063_ChIP-ChIP_OVARY_Human0.91185321
134* SOX2_20726797_ChIP-Seq_SW620_Human0.91100141
135SOX2_19829295_ChIP-Seq_ESCs_Human0.90721436
136NANOG_19829295_ChIP-Seq_ESCs_Human0.90721436
137RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.90097383
138ETV2_25802403_ChIP-Seq_MESCs_Mouse0.90074479
139CTCF_20526341_ChIP-Seq_ESCs_Human0.89723605
140SMAD3_21741376_ChIP-Seq_EPCs_Human0.89625394
141FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.89512041
142MYB_21317192_ChIP-Seq_ERMYB_Mouse0.89219112
143AR_20517297_ChIP-Seq_VCAP_Human0.89089942
144ESR1_21235772_ChIP-Seq_MCF-7_Human0.88810566
145SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.88686879
146NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.87890905
147UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.87886350
148REST_19997604_ChIP-ChIP_NEURONS_Mouse0.87808401
149CBX2_27304074_Chip-Seq_ESCs_Mouse0.87537083
150SPI1_20517297_ChIP-Seq_HL60_Human0.87520051
151* CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.87509074
152STAT3_23295773_ChIP-Seq_U87_Human0.86900438
153BCAT_22108803_ChIP-Seq_LS180_Human0.85939374
154SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.84292403
155GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.83978018
156TAL1_26923725_Chip-Seq_HPCs_Mouse0.83965321
157KDM2B_26808549_Chip-Seq_REH_Human0.83959453
158GATA2_22383799_ChIP-Seq_G1ME_Mouse0.83880348
159SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.83274109
160AR_21572438_ChIP-Seq_LNCaP_Human0.83207414
161PU.1_20513432_ChIP-Seq_Bcells_Mouse0.82679767
162LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82613135
163ZNF217_24962896_ChIP-Seq_MCF-7_Human0.82424572
164GATA3_26560356_Chip-Seq_TH2_Human0.82299932
165PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.82081268
166NR3C1_21868756_ChIP-Seq_MCF10A_Human0.80991711
167CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.80562029
168TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.80001015
169IGF1R_20145208_ChIP-Seq_DFB_Human0.79923144
170* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.79822763
171TAF2_19829295_ChIP-Seq_ESCs_Human0.79369456
172E2F1_20622854_ChIP-Seq_HELA_Human0.79363737
173* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78525547
174SOX2_21211035_ChIP-Seq_LN229_Human0.78494076
175TFEB_21752829_ChIP-Seq_HELA_Human0.78405886
176ESR2_21235772_ChIP-Seq_MCF-7_Human0.77425834
177PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.77334760
178RARB_27405468_Chip-Seq_BRAIN_Mouse0.77234213
179ESR1_20079471_ChIP-ChIP_T-47D_Human0.77043302
180VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.77000625
181RUNX2_22187159_ChIP-Seq_PCA_Human0.76965388
182SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.76695550
183ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.76562148
184AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.76465185

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005464_abnormal_platelet_physiology3.70472733
2MP0004043_abnormal_pH_regulation3.41882372
3MP0002837_dystrophic_cardiac_calcinosis3.36586375
4MP0010386_abnormal_urinary_bladder2.98675020
5MP0001835_abnormal_antigen_presentation2.97200617
6MP0009780_abnormal_chondrocyte_physiolo2.78925038
7MP0003183_abnormal_peptide_metabolism2.78754369
8MP0004270_analgesia2.65542416
9MP0003195_calcinosis2.60344586
10MP0000013_abnormal_adipose_tissue2.52803642
11MP0003724_increased_susceptibility_to2.24788891
12MP0005379_endocrine/exocrine_gland_phen2.19310006
13MP0003172_abnormal_lysosome_physiology2.17337269
14MP0002909_abnormal_adrenal_gland2.15325526
15MP0005645_abnormal_hypothalamus_physiol2.01673325
16MP0003436_decreased_susceptibility_to2.00960635
17MP0003075_altered_response_to1.97570904
18MP0002734_abnormal_mechanical_nocicepti1.95726328
19MP0002148_abnormal_hypersensitivity_rea1.95453631
20MP0002638_abnormal_pupillary_reflex1.94463280
21MP0006276_abnormal_autonomic_nervous1.91448044
22MP0002733_abnormal_thermal_nociception1.81669821
23MP0005671_abnormal_response_to1.75367385
24MP0002735_abnormal_chemical_nociception1.75227985
25MP0000920_abnormal_myelination1.71956836
26MP0002272_abnormal_nervous_system1.70037742
27MP0010329_abnormal_lipoprotein_level1.67060481
28MP0002693_abnormal_pancreas_physiology1.67001991
29MP0001905_abnormal_dopamine_level1.66200354
30MP0005646_abnormal_pituitary_gland1.66173106
31MP0001986_abnormal_taste_sensitivity1.65908140
32MP0005000_abnormal_immune_tolerance1.64797526
33MP0002876_abnormal_thyroid_physiology1.61121477
34MP0001533_abnormal_skeleton_physiology1.60651192
35MP0001944_abnormal_pancreas_morphology1.59638476
36MP0002139_abnormal_hepatobiliary_system1.58801535
37MP0002132_abnormal_respiratory_system1.57987951
38MP0009840_abnormal_foam_cell1.57541674
39MP0003191_abnormal_cellular_cholesterol1.57246891
40MP0006072_abnormal_retinal_apoptosis1.56731249
41MP0001970_abnormal_pain_threshold1.56444254
42MP0003329_amyloid_beta_deposits1.54819199
43MP0003880_abnormal_central_pattern1.53359809
44MP0002877_abnormal_melanocyte_morpholog1.52743000
45MP0005058_abnormal_lysosome_morphology1.51877237
46MP0001958_emphysema1.49392106
47MP0009785_altered_susceptibility_to1.49144015
48MP0001984_abnormal_olfaction1.46167580
49MP0005387_immune_system_phenotype1.44948971
50MP0001790_abnormal_immune_system1.44948971
51MP0003011_delayed_dark_adaptation1.44916693
52MP0004036_abnormal_muscle_relaxation1.44034699
53MP0008004_abnormal_stomach_pH1.42076416
54MP0000343_altered_response_to1.40385351
55MP0001529_abnormal_vocalization1.38824010
56MP0003186_abnormal_redox_activity1.37967775
57MP0005165_increased_susceptibility_to1.35592739
58MP0003806_abnormal_nucleotide_metabolis1.35147331
59MP0000465_gastrointestinal_hemorrhage1.34677423
60MP0002419_abnormal_innate_immunity1.34550756
61MP0000751_myopathy1.34170105
62MP0001873_stomach_inflammation1.34143894
63MP0006082_CNS_inflammation1.31829942
64MP0010155_abnormal_intestine_physiology1.31816600
65MP0001502_abnormal_circadian_rhythm1.31612470
66MP0002078_abnormal_glucose_homeostasis1.30888839
67MP0005535_abnormal_body_temperature1.30812329
68MP0005220_abnormal_exocrine_pancreas1.30169761
69MP0002064_seizures1.29918344
70MP0003879_abnormal_hair_cell1.29510704
71MP0001765_abnormal_ion_homeostasis1.29172651
72MP0000685_abnormal_immune_system1.28895203
73MP0003303_peritoneal_inflammation1.28119925
74MP0005365_abnormal_bile_salt1.26492977
75MP0003634_abnormal_glial_cell1.26469124
76MP0000749_muscle_degeneration1.25780833
77MP0003635_abnormal_synaptic_transmissio1.24923254
78MP0000003_abnormal_adipose_tissue1.23643213
79MP0005085_abnormal_gallbladder_physiolo1.23278847
80MP0001968_abnormal_touch/_nociception1.23203459
81MP0004145_abnormal_muscle_electrophysio1.22136610
82MP0005551_abnormal_eye_electrophysiolog1.22119972
83MP0002229_neurodegeneration1.19263682
84MP0006054_spinal_hemorrhage1.19171294
85MP0005025_abnormal_response_to1.18048480
86MP0005166_decreased_susceptibility_to1.17135446
87MP0001845_abnormal_inflammatory_respons1.16764377
88MP0000230_abnormal_systemic_arterial1.15937585
89MP0005084_abnormal_gallbladder_morpholo1.15077056
90MP0006036_abnormal_mitochondrial_physio1.11749391
91MP0004019_abnormal_vitamin_homeostasis1.11259281
92MP0002736_abnormal_nociception_after1.09873970
93MP0002723_abnormal_immune_serum1.09665738
94MP0005636_abnormal_mineral_homeostasis1.09468059
95MP0004924_abnormal_behavior1.06897261
96MP0005386_behavior/neurological_phenoty1.06897261
97MP0005332_abnormal_amino_acid1.05660861
98MP0002572_abnormal_emotion/affect_behav1.04643539
99MP0009643_abnormal_urine_homeostasis1.04595888
100MP0002163_abnormal_gland_morphology1.04540558
101MP0000538_abnormal_urinary_bladder1.02935071
102MP0009745_abnormal_behavioral_response1.02728109
103MP0002067_abnormal_sensory_capabilities1.01969403
104MP0002452_abnormal_antigen_presenting1.01783767
105MP0000678_abnormal_parathyroid_gland1.01641649
106MP0004510_myositis1.00878021
107MP0008469_abnormal_protein_level1.00784807
108MP0001486_abnormal_startle_reflex1.00589543
109MP0009764_decreased_sensitivity_to1.00232942
110MP0001800_abnormal_humoral_immune0.99907229
111MP0002420_abnormal_adaptive_immunity0.99775407
112MP0002118_abnormal_lipid_homeostasis0.99498410
113MP0005075_abnormal_melanosome_morpholog0.99016350
114MP0001819_abnormal_immune_cell0.98954969
115MP0004142_abnormal_muscle_tone0.98255370
116MP0001661_extended_life_span0.97951619
117MP0001756_abnormal_urination0.96986912
118MP0000747_muscle_weakness0.96654069
119MP0004215_abnormal_myocardial_fiber0.96543457
120MP0005253_abnormal_eye_physiology0.96091958
121MP0004130_abnormal_muscle_cell0.96082632
122MP0009333_abnormal_splenocyte_physiolog0.95377571
123MP0003868_abnormal_feces_composition0.94964080
124MP0008260_abnormal_autophagy0.94472250
125MP0001542_abnormal_bone_strength0.93918494
126MP0001664_abnormal_digestion0.93233475
127MP0008874_decreased_physiological_sensi0.93066391
128MP0002295_abnormal_pulmonary_circulatio0.92544700
129MP0008872_abnormal_physiological_respon0.92267773
130MP0005360_urolithiasis0.92090970
131MP0003300_gastrointestinal_ulcer0.91903070
132MP0000462_abnormal_digestive_system0.91850192
133MP0002184_abnormal_innervation0.91257568
134MP0008875_abnormal_xenobiotic_pharmacok0.91253212
135MP0003283_abnormal_digestive_organ0.90843923
136MP0004147_increased_porphyrin_level0.90769005
137MP0002063_abnormal_learning/memory/cond0.90764779
138MP0004858_abnormal_nervous_system0.90292041
139MP0002405_respiratory_system_inflammati0.89773082
140MP0003959_abnormal_lean_body0.89768681
141MP0001440_abnormal_grooming_behavior0.89388892
142MP0004742_abnormal_vestibular_system0.89318645
143MP0002896_abnormal_bone_mineralization0.88951773
144MP0001666_abnormal_nutrient_absorption0.88528091
145MP0003690_abnormal_glial_cell0.88492582
146MP0003953_abnormal_hormone_level0.88245805
147MP0005083_abnormal_biliary_tract0.87543482
148MP0000955_abnormal_spinal_cord0.87526652
149MP0003866_abnormal_defecation0.87057553
150MP0005448_abnormal_energy_balance0.86198317
151MP0005410_abnormal_fertilization0.85786021
152MP0000604_amyloidosis0.85226769
153MP0001663_abnormal_digestive_system0.84425033
154MP0003633_abnormal_nervous_system0.84405948
155MP0001299_abnormal_eye_distance/0.84303689
156MP0009046_muscle_twitch0.84279770
157MP0009642_abnormal_blood_homeostasis0.83697710
158MP0002972_abnormal_cardiac_muscle0.82530886
159MP0004085_abnormal_heartbeat0.82482311
160MP0005319_abnormal_enzyme/_coenzyme0.82195507
161MP0000015_abnormal_ear_pigmentation0.81405117
162MP0002822_catalepsy0.81320622
163MP0004782_abnormal_surfactant_physiolog0.80746785
164MP0000372_irregular_coat_pigmentation0.80548255
165MP0003638_abnormal_response/metabolism_0.79084438

Predicted human phenotypes

RankGene SetZ-score
1Petechiae (HP:0000967)5.04567549
2Prolonged bleeding time (HP:0003010)4.50718977
3Purpura (HP:0000979)4.18868266
4Hyperinsulinemic hypoglycemia (HP:0000825)3.89957136
5Pheochromocytoma (HP:0002666)3.59300470
6Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.58874820
7Hypoglycemic seizures (HP:0002173)3.57801728
8Hypoglycemic coma (HP:0001325)3.56182681
9Ketoacidosis (HP:0001993)3.48929279
10Menorrhagia (HP:0000132)3.48501427
11Hypothermia (HP:0002045)3.46348995
12Acute necrotizing encephalopathy (HP:0006965)3.39506607
13Neuroendocrine neoplasm (HP:0100634)3.35746210
14Gingival bleeding (HP:0000225)3.34797580
15Symptomatic seizures (HP:0011145)3.34178824
16Epistaxis (HP:0000421)3.27716438
17Abnormal mitochondria in muscle tissue (HP:0008316)3.19913986
18Elevated erythrocyte sedimentation rate (HP:0003565)3.19194478
19Neurofibrillary tangles (HP:0002185)3.05968463
20Hyperlipoproteinemia (HP:0010980)3.05922261
21Acute encephalopathy (HP:0006846)2.97523457
22Abnormality of aromatic amino acid family metabolism (HP:0004338)2.94740782
23Abnormality of liposaccharide metabolism (HP:0010968)2.93059749
24Abnormality of glycosphingolipid metabolism (HP:0004343)2.93059749
25Abnormality of glycolipid metabolism (HP:0010969)2.93059749
26Progressive macrocephaly (HP:0004481)2.91838220
27Stomatitis (HP:0010280)2.90421545
28Mitochondrial inheritance (HP:0001427)2.84163578
29Abnormal platelet volume (HP:0011876)2.82957581
30Increased mean platelet volume (HP:0011877)2.82173394
31Mitral stenosis (HP:0001718)2.80163194
32Abnormality of calcium-phosphate metabolism (HP:0100530)2.76455007
33Hepatic necrosis (HP:0002605)2.70242660
34Generalized aminoaciduria (HP:0002909)2.61762432
35Ketosis (HP:0001946)2.59217108
36Abnormality of mucopolysaccharide metabolism (HP:0011020)2.55391633
37Abnormality of polysaccharide metabolism (HP:0011012)2.55391633
38Abnormality of glycosaminoglycan metabolism (HP:0004371)2.55391633
39Large for gestational age (HP:0001520)2.50010639
40Retinal dysplasia (HP:0007973)2.46074256
41Tongue fasciculations (HP:0001308)2.45008948
42Late onset (HP:0003584)2.43838767
43Increased neuronal autofluorescent lipopigment (HP:0002074)2.41385653
44Episodic fever (HP:0001954)2.41348749
45Hepatocellular necrosis (HP:0001404)2.41346506
46Increased cerebral lipofuscin (HP:0011813)2.40206545
47Vascular calcification (HP:0004934)2.40068611
48Loss of speech (HP:0002371)2.35344254
49Cardiovascular calcification (HP:0011915)2.31902847
50Prolonged neonatal jaundice (HP:0006579)2.31333210
51Decreased circulating renin level (HP:0003351)2.30445249
52Muscle fibrillation (HP:0010546)2.25230033
53Increased CSF lactate (HP:0002490)2.22202442
54Hyperthyroidism (HP:0000836)2.20370248
55Cerebral inclusion bodies (HP:0100314)2.20166110
56Action tremor (HP:0002345)2.17471230
57Renal Fanconi syndrome (HP:0001994)2.17091872
58Protuberant abdomen (HP:0001538)2.16709740
59Hyperglycemia (HP:0003074)2.16007938
60Degeneration of the lateral corticospinal tracts (HP:0002314)2.15376442
61Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.15376442
62Epiphyseal dysplasia (HP:0002656)2.13854649
63Cerebral hemorrhage (HP:0001342)2.13627185
64Atonic seizures (HP:0010819)2.13273300
65Methylmalonic acidemia (HP:0002912)2.12309360
66Cerebral edema (HP:0002181)2.10358698
67Hypokalemia (HP:0002900)2.09966362
68Systemic lupus erythematosus (HP:0002725)2.09408855
69Growth hormone excess (HP:0000845)2.08996365
70Lipid accumulation in hepatocytes (HP:0006561)2.08122207
71Testicular neoplasm (HP:0010788)2.08071344
72Joint swelling (HP:0001386)2.07223900
73Palpitations (HP:0001962)2.06108746
74Impaired platelet aggregation (HP:0003540)2.06042591
75Abnormal platelet function (HP:0011869)2.06042591
76Hepatosplenomegaly (HP:0001433)2.05446097
77Abnormal pupillary function (HP:0007686)2.01749707
78J-shaped sella turcica (HP:0002680)2.01624510
79Myoglobinuria (HP:0002913)2.01281322
80Abnormality of macrophages (HP:0004311)2.01157715
81Increased muscle lipid content (HP:0009058)2.00513344
82Disproportionate short-trunk short stature (HP:0003521)1.99996970
83Vacuolated lymphocytes (HP:0001922)1.99298926
84Xanthomatosis (HP:0000991)1.98700007
85Hypokalemic alkalosis (HP:0001949)1.98243376
86Abnormality of the pancreatic islet cells (HP:0006476)1.97950947
87Abnormality of endocrine pancreas physiology (HP:0012093)1.97950947
88Methylmalonic aciduria (HP:0012120)1.97943918
89Supranuclear gaze palsy (HP:0000605)1.97740003
90Abnormal tarsal ossification (HP:0008369)1.97164530
91Abnormal pancreas size (HP:0012094)1.96643779
92Hyperactive renin-angiotensin system (HP:0000841)1.94460527
93Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.94257750
94Menstrual irregularities (HP:0000858)1.93882210
95Hypotension (HP:0002615)1.92803424
96Conjugated hyperbilirubinemia (HP:0002908)1.92203806
97Abnormality of iron homeostasis (HP:0011031)1.91875023
98Abnormality of the intrinsic pathway (HP:0010989)1.91407054
99Postural tremor (HP:0002174)1.91114988
100Agitation (HP:0000713)1.89845065
101Increased intramyocellular lipid droplets (HP:0012240)1.89430625
102EEG with generalized epileptiform discharges (HP:0011198)1.89322166
103Glycosuria (HP:0003076)1.88816298
104Abnormality of urine glucose concentration (HP:0011016)1.88816298
105Irregular vertebral endplates (HP:0003301)1.88579261
106Abnormality of renin-angiotensin system (HP:0000847)1.88382131
107Anxiety (HP:0000739)1.87697710
108Exercise-induced myalgia (HP:0003738)1.87573797
109Dysostosis multiplex (HP:0000943)1.86906382
110Central scotoma (HP:0000603)1.86356361
111Increased IgM level (HP:0003496)1.85616594
112Optic disc pallor (HP:0000543)1.85022967
113Abnormal respiratory epithelium morphology (HP:0012253)1.84701406
114Abnormal respiratory motile cilium morphology (HP:0005938)1.84701406
115Epileptiform EEG discharges (HP:0011182)1.84196940
116Increased circulating renin level (HP:0000848)1.82662139
117Type II lissencephaly (HP:0007260)1.82621782
118Progressive neurologic deterioration (HP:0002344)1.82082527
119Hyperparathyroidism (HP:0000843)1.81730609
120Increased hepatocellular lipid droplets (HP:0006565)1.80915989
121Abnormality of fatty-acid metabolism (HP:0004359)1.80797339
122Insulin-resistant diabetes mellitus (HP:0000831)1.80558387
1233-Methylglutaconic aciduria (HP:0003535)1.80262675
124Hypsarrhythmia (HP:0002521)1.80122683
125Abnormality of transition element cation homeostasis (HP:0011030)1.79816066
126Increased CSF protein (HP:0002922)1.79721935
127Abnormality of the vertebral endplates (HP:0005106)1.79253609
128Pancreatic islet-cell hyperplasia (HP:0004510)1.78652086
129Albinism (HP:0001022)1.78274016
130Lactic acidosis (HP:0003128)1.77935042
131Mucopolysacchariduria (HP:0008155)1.77690507
132Urinary glycosaminoglycan excretion (HP:0003541)1.77690507
133Limb dystonia (HP:0002451)1.77504175
134Increased serum ferritin (HP:0003281)1.77452882
135Hypomagnesemia (HP:0002917)1.77161933
136Cutaneous melanoma (HP:0012056)1.76801472
137Leukodystrophy (HP:0002415)1.76108167
138Vertebral compression fractures (HP:0002953)1.75970911
139Abnormality of magnesium homeostasis (HP:0004921)1.75184102
140Glucose intolerance (HP:0000833)1.74971563
141Hyperkalemia (HP:0002153)1.74763910
142Respiratory failure (HP:0002878)1.74695339
143Abnormal protein glycosylation (HP:0012346)1.73962946
144Abnormal glycosylation (HP:0012345)1.73962946
145Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.73962946
146Abnormal protein N-linked glycosylation (HP:0012347)1.73962946
147Hyperphosphaturia (HP:0003109)1.72280484
148Congenital sensorineural hearing impairment (HP:0008527)1.72097596
149Type I transferrin isoform profile (HP:0003642)1.71561072
150Dysautonomia (HP:0002459)1.71018442
151Dicarboxylic aciduria (HP:0003215)1.70842891
152Abnormality of dicarboxylic acid metabolism (HP:0010995)1.70842891
153Oligomenorrhea (HP:0000876)1.70282372
154Resting tremor (HP:0002322)1.70232939
155Hypergammaglobulinemia (HP:0010702)1.70107833
156Abnormality of proline metabolism (HP:0010907)1.70060034
157Hydroxyprolinuria (HP:0003080)1.70060034
158Autoamputation (HP:0001218)1.68888321
159Basal ganglia calcification (HP:0002135)1.68610039
160Arthropathy (HP:0003040)1.68598559
161Myositis (HP:0100614)1.68189428
162Joint hemorrhage (HP:0005261)1.64814223
163Polyphagia (HP:0002591)1.64199919
164Bruising susceptibility (HP:0000978)1.63429455
165Bone cyst (HP:0012062)1.62653598
166Cerebral palsy (HP:0100021)1.61989151
167Cardiomegaly (HP:0001640)1.60146171
168Pulmonary infiltrates (HP:0002113)1.57563399
169Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.57080665
170Nuclear cataract (HP:0100018)1.56526624
171Joint stiffness (HP:0001387)1.55632206
172Abnormality of glutamine family amino acid metabolism (HP:0010902)1.55621881
173Amyloidosis (HP:0011034)1.54400980
174Abnormal ciliary motility (HP:0012262)1.53802541
175Rhinitis (HP:0012384)1.50740716
176Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.49809719
177Decreased activity of mitochondrial respiratory chain (HP:0008972)1.49809719
178Acute hepatic failure (HP:0006554)1.47419725
179Obstructive lung disease (HP:0006536)1.46584713

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR3.69447537
2WNK43.25348013
3STK393.12096802
4MAPK152.86582196
5NTRK12.66454110
6RIPK42.45120446
7FES2.34325366
8TNK22.14991332
9TRIM282.10612956
10OXSR12.09482495
11MAP3K22.01215266
12TXK1.85155468
13BCR1.79899904
14BCKDK1.79886600
15PIK3CG1.78706961
16PHKG11.75340686
17PHKG21.75340686
18ZAP701.75180060
19CASK1.70061325
20LIMK11.57471290
21EPHB11.56978697
22IRAK11.53812441
23MAP4K11.53753181
24ARAF1.52757148
25MET1.52603675
26GRK61.51231034
27MAPKAPK31.47613775
28UHMK11.44284059
29MAP3K111.41045973
30NME11.37712473
31FLT31.36954161
32PRKD31.36239149
33PIM21.34570583
34WNK31.33769762
35CAMK2D1.32901623
36MAPKAPK51.30639188
37PAK31.29590275
38MST41.28429615
39MYLK1.27923011
40OBSCN1.27339880
41SGK2231.26930206
42SGK4941.26930206
43IRAK21.24527657
44FRK1.23924869
45HIPK21.23787262
46TBK11.19344656
47NTRK31.18978774
48EPHA31.16221813
49IRAK31.16096958
50GRK51.15805343
51WNK11.15657230
52KIT1.13037661
53EIF2AK11.12560088
54IKBKB1.12314961
55BLK1.12081837
56BMPR1B1.12042282
57PRKCE1.11207995
58CAMK2B1.10998864
59PRKD21.10361742
60DAPK11.09447103
61SYK1.08840789
62TYK21.08584646
63JAK11.08579169
64MAP2K61.08174136
65SIK31.08052989
66TEC1.07661678
67PRPF4B1.07594404
68TIE11.06545319
69AKT31.04521038
70MAP2K31.03271910
71BTK1.01933305
72EIF2AK31.01177267
73MAP2K71.00741004
74DAPK30.99725624
75CSF1R0.97666907
76ILK0.96082924
77LMTK20.94743738
78MUSK0.93903092
79DAPK20.93855467
80TAOK30.93199063
81CAMKK20.92539627
82CAMK2G0.88778103
83PASK0.86778117
84PINK10.86735824
85TNIK0.84702837
86CAMK2A0.84525071
87BMX0.83470046
88MAP3K10.82970850
89KSR20.82945788
90NEK60.82671312
91BMPR20.80818783
92STK380.80505258
93TLK10.80015400
94CSNK1G30.79198915
95CDK190.76355399
96ACVR1B0.76268745
97HCK0.75768955
98MAP3K40.72671411
99MINK10.70514521
100PDK10.70223684
101RET0.70180750
102PKN10.69514769
103MAPK130.68546191
104FER0.68524719
105TAOK20.67952551
106CDK50.67509049
107MAP2K40.66871332
108ADRBK10.66612995
109MAP3K50.65954157
110TRPM70.65482592
111LYN0.64388666
112CSNK1G20.64362149
113TRIB30.64265694
114TAOK10.62656532
115STK160.62358754
116GRK70.61478166
117MAPK120.60564949
118MAP2K20.59161654
119PRKCH0.58774989
120ABL20.58447126
121MAP3K120.58048759
122PDK20.57659342
123MARK10.57156675
124BRAF0.57059303
125PDK30.55129674
126PDK40.55129674
127MAP2K10.55038003
128DYRK20.53326264
129ERN10.53038874
130PRKG20.53021131
131PTK20.52917057
132ERBB30.52100893
133ADRBK20.51957771
134ROCK20.51008853
135JAK20.50419432
136PRKD10.50212811
137RPS6KA20.49420889
138TESK10.49418201
139CSK0.49359865
140TESK20.49163404
141PRKACA0.48693982
142CSNK1G10.48434810
143EPHA40.48081023
144PTK2B0.47754381
145MAP4K20.47411288
146MAP3K30.46773530
147PDPK10.46127599
148SGK20.45959977
149MAP3K60.45686274
150GRK10.45283569
151PRKCQ0.44486791
152JAK30.44399150
153ITK0.43505023
154PKN20.43487602
155LRRK20.43436283
156CAMKK10.42700278
157LCK0.41208370
158SCYL20.40978817

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.96554055
2Maturity onset diabetes of the young_Homo sapiens_hsa049503.77498818
3Sulfur metabolism_Homo sapiens_hsa009203.32629973
4Oxidative phosphorylation_Homo sapiens_hsa001902.80542063
5Fatty acid elongation_Homo sapiens_hsa000622.42787511
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.28649074
7Glycosaminoglycan degradation_Homo sapiens_hsa005312.15308178
8Parkinsons disease_Homo sapiens_hsa050122.14125401
9Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.10518652
10Vibrio cholerae infection_Homo sapiens_hsa051102.01732681
11Steroid biosynthesis_Homo sapiens_hsa001002.00911708
12Alzheimers disease_Homo sapiens_hsa050101.83282041
13Collecting duct acid secretion_Homo sapiens_hsa049661.78926825
14Insulin secretion_Homo sapiens_hsa049111.75118403
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.75116824
16Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.71585111
17Butanoate metabolism_Homo sapiens_hsa006501.67929858
18SNARE interactions in vesicular transport_Homo sapiens_hsa041301.60153103
19Propanoate metabolism_Homo sapiens_hsa006401.56138637
20Synaptic vesicle cycle_Homo sapiens_hsa047211.55639045
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.50302655
22Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.45547841
23Allograft rejection_Homo sapiens_hsa053301.42562949
24Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.42151816
25Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.42101991
26Platelet activation_Homo sapiens_hsa046111.40822901
27Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.39496476
28Histidine metabolism_Homo sapiens_hsa003401.37505938
29Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.33403605
30Chemical carcinogenesis_Homo sapiens_hsa052041.31823485
31Graft-versus-host disease_Homo sapiens_hsa053321.30038384
32Fatty acid metabolism_Homo sapiens_hsa012121.28809831
33Phenylalanine metabolism_Homo sapiens_hsa003601.28607528
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.24585235
35Fatty acid degradation_Homo sapiens_hsa000711.23521183
36Cocaine addiction_Homo sapiens_hsa050301.22928584
37Pyruvate metabolism_Homo sapiens_hsa006201.20791348
38Cardiac muscle contraction_Homo sapiens_hsa042601.13845850
39Huntingtons disease_Homo sapiens_hsa050161.13750185
40Regulation of autophagy_Homo sapiens_hsa041401.13367922
41Tyrosine metabolism_Homo sapiens_hsa003501.10937356
42Serotonergic synapse_Homo sapiens_hsa047261.09143405
43Glutathione metabolism_Homo sapiens_hsa004801.06587077
44Tryptophan metabolism_Homo sapiens_hsa003801.05454881
45Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.04611667
46Hematopoietic cell lineage_Homo sapiens_hsa046401.04482865
47Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.03720348
48Autoimmune thyroid disease_Homo sapiens_hsa053201.02947339
49Peroxisome_Homo sapiens_hsa041461.02921458
50Ether lipid metabolism_Homo sapiens_hsa005651.01288943
51Sphingolipid metabolism_Homo sapiens_hsa006001.01103376
52Lysosome_Homo sapiens_hsa041420.98243301
53GABAergic synapse_Homo sapiens_hsa047270.96808275
54Taste transduction_Homo sapiens_hsa047420.95132340
55Other glycan degradation_Homo sapiens_hsa005110.94548575
56Folate biosynthesis_Homo sapiens_hsa007900.94546421
57Intestinal immune network for IgA production_Homo sapiens_hsa046720.94222116
58Asthma_Homo sapiens_hsa053100.94034486
59Pentose and glucuronate interconversions_Homo sapiens_hsa000400.91140040
60Staphylococcus aureus infection_Homo sapiens_hsa051500.90720205
61Renin-angiotensin system_Homo sapiens_hsa046140.90025899
62Dopaminergic synapse_Homo sapiens_hsa047280.88986602
63Amphetamine addiction_Homo sapiens_hsa050310.88111003
64Circadian entrainment_Homo sapiens_hsa047130.86513616
65Pancreatic secretion_Homo sapiens_hsa049720.79415440
66Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.79133552
67Steroid hormone biosynthesis_Homo sapiens_hsa001400.78199410
68Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.77484863
69Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.76556179
70Complement and coagulation cascades_Homo sapiens_hsa046100.74739508
71Arginine and proline metabolism_Homo sapiens_hsa003300.74483078
72Cholinergic synapse_Homo sapiens_hsa047250.74344414
73Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.73838478
74Leishmaniasis_Homo sapiens_hsa051400.71214545
75Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.69421795
76Linoleic acid metabolism_Homo sapiens_hsa005910.68631671
77Phototransduction_Homo sapiens_hsa047440.67032283
78Morphine addiction_Homo sapiens_hsa050320.66774684
79Olfactory transduction_Homo sapiens_hsa047400.65784181
80Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.65254820
81N-Glycan biosynthesis_Homo sapiens_hsa005100.65024287
82alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.64372355
83Malaria_Homo sapiens_hsa051440.63072639
84Type II diabetes mellitus_Homo sapiens_hsa049300.62329664
85Carbohydrate digestion and absorption_Homo sapiens_hsa049730.62190344
86Phagosome_Homo sapiens_hsa041450.61204561
87Tuberculosis_Homo sapiens_hsa051520.61087217
88Endocytosis_Homo sapiens_hsa041440.61075562
89Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.60269165
90Osteoclast differentiation_Homo sapiens_hsa043800.59925423
91Thyroid hormone synthesis_Homo sapiens_hsa049180.59242643
92Retinol metabolism_Homo sapiens_hsa008300.59059239
93Antigen processing and presentation_Homo sapiens_hsa046120.58879188
94Vascular smooth muscle contraction_Homo sapiens_hsa042700.57305573
95Pertussis_Homo sapiens_hsa051330.56402744
96Rheumatoid arthritis_Homo sapiens_hsa053230.56177556
97Renin secretion_Homo sapiens_hsa049240.55999020
98Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55525555
99Mineral absorption_Homo sapiens_hsa049780.54442061
100Metabolic pathways_Homo sapiens_hsa011000.53686780
101Glutamatergic synapse_Homo sapiens_hsa047240.52734835
102Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.52351951
103Primary bile acid biosynthesis_Homo sapiens_hsa001200.51777552
104Starch and sucrose metabolism_Homo sapiens_hsa005000.51113039
105Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.48229291
106Proteasome_Homo sapiens_hsa030500.48096712
107Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.47783003
108Adipocytokine signaling pathway_Homo sapiens_hsa049200.46426068
109Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.46195839
110Jak-STAT signaling pathway_Homo sapiens_hsa046300.45888101
111beta-Alanine metabolism_Homo sapiens_hsa004100.44966896
112Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.44570897
113Aldosterone synthesis and secretion_Homo sapiens_hsa049250.44479411
114Salmonella infection_Homo sapiens_hsa051320.44230357
115Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.43874286
116PPAR signaling pathway_Homo sapiens_hsa033200.43038423
117ABC transporters_Homo sapiens_hsa020100.42622141
118Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.42490473
119Glucagon signaling pathway_Homo sapiens_hsa049220.42168197
120Circadian rhythm_Homo sapiens_hsa047100.41161658
121Pentose phosphate pathway_Homo sapiens_hsa000300.40742970
122Protein digestion and absorption_Homo sapiens_hsa049740.40368306
123Nitrogen metabolism_Homo sapiens_hsa009100.40110234
124Glycerophospholipid metabolism_Homo sapiens_hsa005640.38909211
125Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.38731216
126Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.38077587
127Galactose metabolism_Homo sapiens_hsa000520.37583391
128Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.37540205
129Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.37407002
130Drug metabolism - other enzymes_Homo sapiens_hsa009830.36979841
131Arachidonic acid metabolism_Homo sapiens_hsa005900.36854752
132Salivary secretion_Homo sapiens_hsa049700.36763671
133Glycerolipid metabolism_Homo sapiens_hsa005610.36671663
134Fat digestion and absorption_Homo sapiens_hsa049750.36460406
135Fructose and mannose metabolism_Homo sapiens_hsa000510.35935292
136African trypanosomiasis_Homo sapiens_hsa051430.35662218
137Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.34780111
138Gastric acid secretion_Homo sapiens_hsa049710.34697159
139Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.34391887
140Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.34378343
141Type I diabetes mellitus_Homo sapiens_hsa049400.33819864
142Long-term potentiation_Homo sapiens_hsa047200.32650369

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