

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | cilium or flagellum-dependent cell motility (GO:0001539) | 9.70821463 |
| 2 | sperm motility (GO:0030317) | 9.23512567 |
| 3 | epithelial cilium movement (GO:0003351) | 8.82530786 |
| 4 | axonemal dynein complex assembly (GO:0070286) | 8.66764446 |
| 5 | acrosome reaction (GO:0007340) | 8.54095778 |
| 6 | fusion of sperm to egg plasma membrane (GO:0007342) | 8.27702408 |
| 7 | cilium movement (GO:0003341) | 7.68755172 |
| 8 | acrosome assembly (GO:0001675) | 7.47685487 |
| 9 | motile cilium assembly (GO:0044458) | 7.33353896 |
| 10 | regulation of cilium movement (GO:0003352) | 7.30911803 |
| 11 | sperm-egg recognition (GO:0035036) | 7.28094007 |
| 12 | multicellular organism reproduction (GO:0032504) | 7.25879093 |
| 13 | cell wall macromolecule catabolic process (GO:0016998) | 6.98119993 |
| 14 | cell wall macromolecule metabolic process (GO:0044036) | 6.98119993 |
| 15 | epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287) | 6.94947949 |
| 16 | spermatid development (GO:0007286) | 6.65742786 |
| 17 | binding of sperm to zona pellucida (GO:0007339) | 6.58911530 |
| 18 | plasma membrane fusion (GO:0045026) | 6.53918005 |
| 19 | cell-cell recognition (GO:0009988) | 6.42118685 |
| 20 | piRNA metabolic process (GO:0034587) | 6.19541289 |
| 21 | reproduction (GO:0000003) | 5.86059269 |
| 22 | male meiosis (GO:0007140) | 5.68162266 |
| 23 | single fertilization (GO:0007338) | 5.35733053 |
| 24 | protein localization to cilium (GO:0061512) | 5.21560123 |
| 25 | synaptonemal complex organization (GO:0070193) | 5.00208034 |
| 26 | calcium ion-dependent exocytosis (GO:0017156) | 4.99112886 |
| 27 | sperm capacitation (GO:0048240) | 4.97664703 |
| 28 | behavioral response to nicotine (GO:0035095) | 4.87888813 |
| 29 | negative regulation of inclusion body assembly (GO:0090084) | 4.75903544 |
| 30 | ventricular system development (GO:0021591) | 4.74601291 |
| 31 | microtubule depolymerization (GO:0007019) | 4.62951940 |
| 32 | left/right pattern formation (GO:0060972) | 4.54222415 |
| 33 | synaptonemal complex assembly (GO:0007130) | 4.48398110 |
| 34 | microtubule bundle formation (GO:0001578) | 4.37216489 |
| 35 | fertilization (GO:0009566) | 4.35872830 |
| 36 | regulation of microtubule-based movement (GO:0060632) | 4.29482821 |
| 37 | pyrimidine nucleobase catabolic process (GO:0006208) | 4.23568942 |
| 38 | DNA methylation involved in gamete generation (GO:0043046) | 4.23020467 |
| 39 | intraciliary transport (GO:0042073) | 4.21474427 |
| 40 | spermatogenesis (GO:0007283) | 4.20440758 |
| 41 | male gamete generation (GO:0048232) | 4.18395284 |
| 42 | cell recognition (GO:0008037) | 4.13702236 |
| 43 | regulation of inclusion body assembly (GO:0090083) | 3.92653644 |
| 44 | left/right axis specification (GO:0070986) | 3.84966743 |
| 45 | gamete generation (GO:0007276) | 3.84428944 |
| 46 | neuron cell-cell adhesion (GO:0007158) | 3.83820155 |
| 47 | microtubule severing (GO:0051013) | 3.82750106 |
| 48 | male meiosis I (GO:0007141) | 3.77496989 |
| 49 | germ cell development (GO:0007281) | 3.70579242 |
| 50 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 3.67515180 |
| 51 | organic cation transport (GO:0015695) | 3.64718295 |
| 52 | spermatid nucleus differentiation (GO:0007289) | 3.63485260 |
| 53 | protein polyglutamylation (GO:0018095) | 3.58858684 |
| 54 | cellular process involved in reproduction in multicellular organism (GO:0022412) | 3.56624332 |
| 55 | GTP biosynthetic process (GO:0006183) | 3.56048919 |
| 56 | auditory behavior (GO:0031223) | 3.55876243 |
| 57 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 3.46627538 |
| 58 | axoneme assembly (GO:0035082) | 3.45779888 |
| 59 | cilium assembly (GO:0042384) | 3.44917968 |
| 60 | mechanosensory behavior (GO:0007638) | 3.44329213 |
| 61 | cilium organization (GO:0044782) | 3.44226257 |
| 62 | nucleoside diphosphate phosphorylation (GO:0006165) | 3.41032247 |
| 63 | neurofilament cytoskeleton organization (GO:0060052) | 3.37301078 |
| 64 | nucleobase catabolic process (GO:0046113) | 3.37235174 |
| 65 | regulation of protein kinase A signaling (GO:0010738) | 3.25662812 |
| 66 | cilium morphogenesis (GO:0060271) | 3.23796409 |
| 67 | protein localization to synapse (GO:0035418) | 3.22504852 |
| 68 | vocalization behavior (GO:0071625) | 3.20236642 |
| 69 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 3.20024365 |
| 70 | glutamate receptor signaling pathway (GO:0007215) | 3.13929165 |
| 71 | membrane depolarization during action potential (GO:0086010) | 3.13896582 |
| 72 | neurotransmitter catabolic process (GO:0042135) | 3.10462312 |
| 73 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 3.08456068 |
| 74 | chromosome organization involved in meiosis (GO:0070192) | 3.05270770 |
| 75 | multicellular organismal reproductive process (GO:0048609) | 3.03568714 |
| 76 | microtubule-based movement (GO:0007018) | 2.99770688 |
| 77 | negative regulation of T cell differentiation in thymus (GO:0033085) | 2.98667068 |
| 78 | presynaptic membrane organization (GO:0097090) | 2.98446615 |
| 79 | nonmotile primary cilium assembly (GO:0035058) | 2.97786699 |
| 80 | dendritic spine morphogenesis (GO:0060997) | 2.97438283 |
| 81 | cellular component assembly involved in morphogenesis (GO:0010927) | 2.94583100 |
| 82 | response to auditory stimulus (GO:0010996) | 2.94564131 |
| 83 | neuronal action potential propagation (GO:0019227) | 2.90189021 |
| 84 | axonal fasciculation (GO:0007413) | 2.88587004 |
| 85 | retinal cone cell development (GO:0046549) | 2.86531490 |
| 86 | UTP biosynthetic process (GO:0006228) | 2.85985876 |
| 87 | neuron recognition (GO:0008038) | 2.83414911 |
| 88 | meiotic nuclear division (GO:0007126) | 2.83119363 |
| 89 | establishment or maintenance of monopolar cell polarity (GO:0061339) | 2.82357186 |
| 90 | establishment of monopolar cell polarity (GO:0061162) | 2.82357186 |
| 91 | negative regulation of synaptic transmission, glutamatergic (GO:0051967) | 2.82240954 |
| 92 | meiosis I (GO:0007127) | 2.80799917 |
| 93 | synaptic transmission, cholinergic (GO:0007271) | 2.79858774 |
| 94 | calcium ion import (GO:0070509) | 2.79465292 |
| 95 | seminiferous tubule development (GO:0072520) | 2.78878334 |
| 96 | regulation of collateral sprouting (GO:0048670) | 2.78095223 |
| 97 | retina layer formation (GO:0010842) | 2.76204736 |
| 98 | transmission of nerve impulse (GO:0019226) | 2.75637442 |
| 99 | primary alcohol catabolic process (GO:0034310) | 2.70604603 |
| 100 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 2.70599876 |
| 101 | smoothened signaling pathway (GO:0007224) | 2.70178326 |
| 102 | cell projection assembly (GO:0030031) | 2.69636644 |
| 103 | startle response (GO:0001964) | 2.69358157 |
| 104 | negative regulation of synaptic transmission, GABAergic (GO:0032229) | 2.69087386 |
| 105 | energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988) | 2.68189269 |
| 106 | ATP hydrolysis coupled proton transport (GO:0015991) | 2.68189269 |
| 107 | lactate metabolic process (GO:0006089) | 2.67020746 |
| 108 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 2.66463766 |
| 109 | centriole assembly (GO:0098534) | 2.66269607 |
| 110 | synaptic transmission, glutamatergic (GO:0035249) | 2.66053613 |
| 111 | presynaptic membrane assembly (GO:0097105) | 2.65394129 |
| 112 | substrate-independent telencephalic tangential migration (GO:0021826) | 2.64905330 |
| 113 | substrate-independent telencephalic tangential interneuron migration (GO:0021843) | 2.64905330 |
| 114 | retinal rod cell development (GO:0046548) | 2.64874477 |
| 115 | urinary tract smooth muscle contraction (GO:0014848) | 2.64768379 |
| 116 | polyol catabolic process (GO:0046174) | 2.61906617 |
| 117 | determination of left/right symmetry (GO:0007368) | 2.60268751 |
| 118 | regulation of glutamate receptor signaling pathway (GO:1900449) | 2.60257716 |
| 119 | vitamin transmembrane transport (GO:0035461) | 2.58800011 |
| 120 | spinal cord motor neuron differentiation (GO:0021522) | 2.58519332 |
| 121 | cochlea development (GO:0090102) | 2.57741020 |
| 122 | microtubule polymerization or depolymerization (GO:0031109) | 2.57299409 |
| 123 | retinal ganglion cell axon guidance (GO:0031290) | 2.56539630 |
| 124 | gamma-aminobutyric acid signaling pathway (GO:0007214) | 2.55777438 |
| 125 | multicellular organismal development (GO:0007275) | 2.53848732 |
| 126 | neuron-neuron synaptic transmission (GO:0007270) | 2.53190404 |
| 127 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 2.52419722 |
| 128 | positive regulation of gastrulation (GO:2000543) | 2.52355203 |
| 129 | synaptic vesicle exocytosis (GO:0016079) | 2.51697770 |
| 130 | negative regulation of response to food (GO:0032096) | 2.47408291 |
| 131 | negative regulation of appetite (GO:0032099) | 2.47408291 |
| 132 | response to acidic pH (GO:0010447) | 2.47203682 |
| 133 | response to histamine (GO:0034776) | 2.47172875 |
| 134 | embryonic body morphogenesis (GO:0010172) | 2.46447271 |
| 135 | detection of calcium ion (GO:0005513) | 2.46065312 |
| 136 | G-protein coupled glutamate receptor signaling pathway (GO:0007216) | 2.45707083 |
| 137 | postsynaptic membrane organization (GO:0001941) | 2.45455300 |
| 138 | tachykinin receptor signaling pathway (GO:0007217) | 2.45241074 |
| 139 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 2.45046526 |
| 140 | ATP synthesis coupled proton transport (GO:0015986) | 2.45046526 |
| 141 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 2.45022490 |
| 142 | lateral ventricle development (GO:0021670) | 2.44501171 |
| 143 | cell proliferation in forebrain (GO:0021846) | 2.43743269 |
| 144 | positive regulation of synapse assembly (GO:0051965) | 2.43670701 |
| 145 | neurotransmitter-gated ion channel clustering (GO:0072578) | 2.43272717 |
| 146 | positive regulation of microtubule polymerization or depolymerization (GO:0031112) | 2.43255174 |
| 147 | sequestering of actin monomers (GO:0042989) | 2.42472683 |
| 148 | cell migration in hindbrain (GO:0021535) | 2.42055613 |
| 149 | central nervous system projection neuron axonogenesis (GO:0021952) | 2.41963088 |
| 150 | cell differentiation in spinal cord (GO:0021515) | 2.41391148 |
| 151 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 2.39002705 |
| 152 | UTP metabolic process (GO:0046051) | 2.38482238 |
| 153 | determination of bilateral symmetry (GO:0009855) | 2.38355859 |
| 154 | terpenoid biosynthetic process (GO:0016114) | 2.37648545 |
| 155 | one-carbon compound transport (GO:0019755) | 2.36606484 |
| 156 | lung epithelium development (GO:0060428) | 2.35996268 |
| 157 | neuronal action potential (GO:0019228) | 2.35935698 |
| 158 | behavioral response to cocaine (GO:0048148) | 2.35523105 |
| 159 | neurotransmitter metabolic process (GO:0042133) | 2.35376208 |
| 160 | epithelial cell differentiation involved in kidney development (GO:0035850) | 2.33852981 |
| 161 | central nervous system myelination (GO:0022010) | 2.33583507 |
| 162 | axon ensheathment in central nervous system (GO:0032291) | 2.33583507 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 7.15984118 |
| 2 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 4.17270109 |
| 3 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 3.69641350 |
| 4 | GBX2_23144817_ChIP-Seq_PC3_Human | 3.02419050 |
| 5 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 3.01290821 |
| 6 | TAF15_26573619_Chip-Seq_HEK293_Human | 2.57452662 |
| 7 | VDR_22108803_ChIP-Seq_LS180_Human | 2.53700731 |
| 8 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 2.37569695 |
| 9 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 2.29573331 |
| 10 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 2.24407108 |
| 11 | REST_21632747_ChIP-Seq_MESCs_Mouse | 2.21967742 |
| 12 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 2.21697191 |
| 13 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 2.15118395 |
| 14 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 2.09888860 |
| 15 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.00565591 |
| 16 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.87558473 |
| 17 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.86208668 |
| 18 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 1.84704995 |
| 19 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.84061944 |
| 20 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.81392718 |
| 21 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 1.81313029 |
| 22 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.81224950 |
| 23 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 1.77996105 |
| 24 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.75626495 |
| 25 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.73352399 |
| 26 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 1.69220049 |
| 27 | SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 1.65767828 |
| 28 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.62995679 |
| 29 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 1.62798369 |
| 30 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.59526363 |
| 31 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.57205973 |
| 32 | P300_19829295_ChIP-Seq_ESCs_Human | 1.53353236 |
| 33 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.53050415 |
| 34 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 1.52401661 |
| 35 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 1.51824010 |
| 36 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 1.50595651 |
| 37 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.49533207 |
| 38 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 1.49353759 |
| 39 | FUS_26573619_Chip-Seq_HEK293_Human | 1.48406921 |
| 40 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.48328044 |
| 41 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 1.46550477 |
| 42 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 1.45950250 |
| 43 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 1.45160917 |
| 44 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 1.44212124 |
| 45 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 1.42159253 |
| 46 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 1.41393202 |
| 47 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 1.40361377 |
| 48 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 1.40361377 |
| 49 | NANOG_18555785_Chip-Seq_ESCs_Mouse | 1.39411583 |
| 50 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 1.38744712 |
| 51 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.37898554 |
| 52 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.35951790 |
| 53 | KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse | 1.35735911 |
| 54 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 1.35648427 |
| 55 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.35033094 |
| 56 | BCAT_22108803_ChIP-Seq_LS180_Human | 1.34445505 |
| 57 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.33835778 |
| 58 | KDM2B_26808549_Chip-Seq_REH_Human | 1.33645416 |
| 59 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.32782394 |
| 60 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 1.32782394 |
| 61 | EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse | 1.31588548 |
| 62 | EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human | 1.29645064 |
| 63 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.29090039 |
| 64 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.27296850 |
| 65 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.27296850 |
| 66 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 1.26999625 |
| 67 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.26722232 |
| 68 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.26677216 |
| 69 | P53_22387025_ChIP-Seq_ESCs_Mouse | 1.25869307 |
| 70 | TAL1_26923725_Chip-Seq_HPCs_Mouse | 1.25309486 |
| 71 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.24117873 |
| 72 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 1.22957945 |
| 73 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.22596249 |
| 74 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.21741291 |
| 75 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.20404968 |
| 76 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.20290638 |
| 77 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 1.18217912 |
| 78 | CMYC_18555785_Chip-Seq_ESCs_Mouse | 1.15753244 |
| 79 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.15602895 |
| 80 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 1.14576555 |
| 81 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.14083525 |
| 82 | STAT3_23295773_ChIP-Seq_U87_Human | 1.14064865 |
| 83 | RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 1.13922730 |
| 84 | CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.13644406 |
| 85 | TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse | 1.12965798 |
| 86 | AR_25329375_ChIP-Seq_VCAP_Human | 1.12789660 |
| 87 | E2F1_18555785_Chip-Seq_ESCs_Mouse | 1.12446108 |
| 88 | TCF4_23295773_ChIP-Seq_U87_Human | 1.11686798 |
| 89 | SUZ12_18555785_Chip-Seq_ESCs_Mouse | 1.11664523 |
| 90 | DROSHA_22980978_ChIP-Seq_HELA_Human | 1.11438246 |
| 91 | EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse | 1.11200183 |
| 92 | CEBPB_26923725_Chip-Seq_MESODERM_Mouse | 1.10536222 |
| 93 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.09859326 |
| 94 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 1.09193354 |
| 95 | EWS_26573619_Chip-Seq_HEK293_Human | 1.08820148 |
| 96 | SMAD3_21741376_ChIP-Seq_ESCs_Human | 1.07768010 |
| 97 | P300_18555785_Chip-Seq_ESCs_Mouse | 1.07448616 |
| 98 | * SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 1.07444840 |
| 99 | RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 1.07144609 |
| 100 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.07122242 |
| 101 | CTCF_27219007_Chip-Seq_Bcells_Human | 1.06774418 |
| 102 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.06745908 |
| 103 | GATA1_26923725_Chip-Seq_HPCs_Mouse | 1.06287013 |
| 104 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.05992386 |
| 105 | ELK4_26923725_Chip-Seq_MESODERM_Mouse | 1.05827476 |
| 106 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.03316017 |
| 107 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.03062777 |
| 108 | SMAD4_21741376_ChIP-Seq_EPCs_Human | 1.02415237 |
| 109 | FLI1_21867929_ChIP-Seq_TH2_Mouse | 1.02187103 |
| 110 | RUNX2_22187159_ChIP-Seq_PCA_Human | 1.02136838 |
| 111 | ETV2_25802403_ChIP-Seq_MESCs_Mouse | 1.02120645 |
| 112 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.01674581 |
| 113 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.01672478 |
| 114 | * TCF4_22108803_ChIP-Seq_LS180_Human | 1.01458924 |
| 115 | STAT3_18555785_Chip-Seq_ESCs_Mouse | 1.01238034 |
| 116 | SOX2_18555785_Chip-Seq_ESCs_Mouse | 0.99811148 |
| 117 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 0.98639185 |
| 118 | TDRD3_21172665_ChIP-Seq_MCF-7_Human | 0.97957910 |
| 119 | SOX9_26525672_Chip-Seq_HEART_Mouse | 0.97626463 |
| 120 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 0.97612156 |
| 121 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 0.96706055 |
| 122 | PRDM14_20953172_ChIP-Seq_ESCs_Human | 0.94547767 |
| 123 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 0.94368252 |
| 124 | ETV1_20927104_ChIP-Seq_GIST48_Human | 0.94007493 |
| 125 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 0.93543738 |
| 126 | WDR5_24793694_ChIP-Seq_LNCAP_Human | 0.92919791 |
| 127 | TBL1_22424771_ChIP-Seq_293T_Human | 0.91967452 |
| 128 | STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse | 0.91948600 |
| 129 | AR_19668381_ChIP-Seq_PC3_Human | 0.91443681 |
| 130 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 0.90425706 |
| 131 | AHR_22903824_ChIP-Seq_MCF-7_Human | 0.90424486 |
| 132 | NCOR_22424771_ChIP-Seq_293T_Human | 0.89470803 |
| 133 | JUN_21703547_ChIP-Seq_K562_Human | 0.89269881 |
| 134 | NANOG_19829295_ChIP-Seq_ESCs_Human | 0.87355051 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0005410_abnormal_fertilization | 8.54035688 |
| 2 | MP0003880_abnormal_central_pattern | 3.87460425 |
| 3 | MP0003698_abnormal_male_reproductive | 3.44415321 |
| 4 | MP0001984_abnormal_olfaction | 2.94217642 |
| 5 | MP0004859_abnormal_synaptic_plasticity | 2.80650035 |
| 6 | MP0001929_abnormal_gametogenesis | 2.75950794 |
| 7 | MP0009046_muscle_twitch | 2.75625119 |
| 8 | MP0008877_abnormal_DNA_methylation | 2.65522570 |
| 9 | MP0003635_abnormal_synaptic_transmissio | 2.60194456 |
| 10 | MP0004133_heterotaxia | 2.59270921 |
| 11 | MP0001968_abnormal_touch/_nociception | 2.49996032 |
| 12 | MP0000566_synostosis | 2.48300799 |
| 13 | MP0006276_abnormal_autonomic_nervous | 2.47187512 |
| 14 | MP0009745_abnormal_behavioral_response | 2.40439955 |
| 15 | MP0002736_abnormal_nociception_after | 2.36574893 |
| 16 | MP0008875_abnormal_xenobiotic_pharmacok | 2.33097939 |
| 17 | MP0002572_abnormal_emotion/affect_behav | 2.23141227 |
| 18 | MP0004270_analgesia | 2.20256774 |
| 19 | MP0002063_abnormal_learning/memory/cond | 2.19422694 |
| 20 | MP0004885_abnormal_endolymph | 2.12445538 |
| 21 | MP0002064_seizures | 2.10913297 |
| 22 | MP0002272_abnormal_nervous_system | 2.03892337 |
| 23 | MP0002735_abnormal_chemical_nociception | 2.01441714 |
| 24 | MP0001501_abnormal_sleep_pattern | 1.91035835 |
| 25 | MP0001440_abnormal_grooming_behavior | 1.85422577 |
| 26 | MP0002210_abnormal_sex_determination | 1.82461440 |
| 27 | MP0002161_abnormal_fertility/fecundity | 1.82082438 |
| 28 | MP0001486_abnormal_startle_reflex | 1.81983510 |
| 29 | MP0002734_abnormal_mechanical_nocicepti | 1.79597605 |
| 30 | MP0002184_abnormal_innervation | 1.76161145 |
| 31 | MP0009379_abnormal_foot_pigmentation | 1.75391021 |
| 32 | MP0002653_abnormal_ependyma_morphology | 1.72987172 |
| 33 | MP0004043_abnormal_pH_regulation | 1.71860844 |
| 34 | MP0005423_abnormal_somatic_nervous | 1.71299083 |
| 35 | MP0000778_abnormal_nervous_system | 1.69647669 |
| 36 | MP0002067_abnormal_sensory_capabilities | 1.68396791 |
| 37 | MP0001188_hyperpigmentation | 1.67793581 |
| 38 | MP0003121_genomic_imprinting | 1.67395263 |
| 39 | MP0005645_abnormal_hypothalamus_physiol | 1.61405811 |
| 40 | MP0010386_abnormal_urinary_bladder | 1.59565808 |
| 41 | MP0002822_catalepsy | 1.59532210 |
| 42 | MP0002557_abnormal_social/conspecific_i | 1.57946671 |
| 43 | MP0002733_abnormal_thermal_nociception | 1.53304405 |
| 44 | MP0002638_abnormal_pupillary_reflex | 1.51290352 |
| 45 | MP0001529_abnormal_vocalization | 1.50710673 |
| 46 | MP0003787_abnormal_imprinting | 1.46151031 |
| 47 | MP0004742_abnormal_vestibular_system | 1.45407204 |
| 48 | MP0001145_abnormal_male_reproductive | 1.44558592 |
| 49 | MP0002160_abnormal_reproductive_system | 1.44387757 |
| 50 | MP0001970_abnormal_pain_threshold | 1.42421193 |
| 51 | MP0003890_abnormal_embryonic-extraembry | 1.39003560 |
| 52 | MP0001905_abnormal_dopamine_level | 1.36570580 |
| 53 | MP0002102_abnormal_ear_morphology | 1.36195858 |
| 54 | MP0004142_abnormal_muscle_tone | 1.28046815 |
| 55 | MP0000653_abnormal_sex_gland | 1.27404037 |
| 56 | MP0003123_paternal_imprinting | 1.25598749 |
| 57 | MP0003879_abnormal_hair_cell | 1.19111228 |
| 58 | MP0003011_delayed_dark_adaptation | 1.14445543 |
| 59 | MP0009780_abnormal_chondrocyte_physiolo | 1.13010231 |
| 60 | MP0004924_abnormal_behavior | 1.11995285 |
| 61 | MP0005386_behavior/neurological_phenoty | 1.11995285 |
| 62 | MP0005551_abnormal_eye_electrophysiolog | 1.11474761 |
| 63 | MP0003122_maternal_imprinting | 1.11020403 |
| 64 | MP0001502_abnormal_circadian_rhythm | 1.09330898 |
| 65 | MP0005623_abnormal_meninges_morphology | 1.09329855 |
| 66 | MP0002882_abnormal_neuron_morphology | 1.09148904 |
| 67 | MP0004811_abnormal_neuron_physiology | 1.05280717 |
| 68 | MP0000955_abnormal_spinal_cord | 1.05130881 |
| 69 | MP0006292_abnormal_olfactory_placode | 1.04143276 |
| 70 | MP0003646_muscle_fatigue | 1.03549483 |
| 71 | MP0005195_abnormal_posterior_eye | 1.03408450 |
| 72 | MP0008872_abnormal_physiological_respon | 1.02550629 |
| 73 | MP0004145_abnormal_muscle_electrophysio | 1.01970750 |
| 74 | MP0002909_abnormal_adrenal_gland | 0.99915191 |
| 75 | MP0005646_abnormal_pituitary_gland | 0.99334422 |
| 76 | MP0002282_abnormal_trachea_morphology | 0.99132580 |
| 77 | MP0003938_abnormal_ear_development | 0.99073645 |
| 78 | MP0002152_abnormal_brain_morphology | 0.98964701 |
| 79 | MP0002876_abnormal_thyroid_physiology | 0.98663458 |
| 80 | MP0002066_abnormal_motor_capabilities/c | 0.98252621 |
| 81 | MP0005187_abnormal_penis_morphology | 0.97907159 |
| 82 | MP0008569_lethality_at_weaning | 0.97643260 |
| 83 | MP0005409_darkened_coat_color | 0.97277914 |
| 84 | MP0005394_taste/olfaction_phenotype | 0.94209108 |
| 85 | MP0005499_abnormal_olfactory_system | 0.94209108 |
| 86 | MP0001963_abnormal_hearing_physiology | 0.93979049 |
| 87 | MP0002752_abnormal_somatic_nervous | 0.92747471 |
| 88 | MP0000631_abnormal_neuroendocrine_gland | 0.91756356 |
| 89 | MP0003283_abnormal_digestive_organ | 0.90095046 |
| 90 | MP0003195_calcinosis | 0.89255189 |
| 91 | MP0001293_anophthalmia | 0.86412555 |
| 92 | MP0000026_abnormal_inner_ear | 0.86231282 |
| 93 | MP0002928_abnormal_bile_duct | 0.83131070 |
| 94 | MP0000015_abnormal_ear_pigmentation | 0.83082322 |
| 95 | MP0008789_abnormal_olfactory_epithelium | 0.82291921 |
| 96 | MP0006072_abnormal_retinal_apoptosis | 0.81421204 |
| 97 | MP0002938_white_spotting | 0.80465425 |
| 98 | MP0001324_abnormal_eye_pigmentation | 0.80379068 |
| 99 | MP0008995_early_reproductive_senescence | 0.78719212 |
| 100 | MP0000569_abnormal_digit_pigmentation | 0.78517490 |
| 101 | MP0001986_abnormal_taste_sensitivity | 0.78032539 |
| 102 | MP0002837_dystrophic_cardiac_calcinosis | 0.76105008 |
| 103 | MP0000751_myopathy | 0.75130578 |
| 104 | MP0001485_abnormal_pinna_reflex | 0.72751117 |
| 105 | MP0003136_yellow_coat_color | 0.72503727 |
| 106 | MP0000049_abnormal_middle_ear | 0.72317957 |
| 107 | MP0001765_abnormal_ion_homeostasis | 0.71969442 |
| 108 | MP0005389_reproductive_system_phenotype | 0.71121208 |
| 109 | MP0002234_abnormal_pharynx_morphology | 0.69924984 |
| 110 | MP0002751_abnormal_autonomic_nervous | 0.69477453 |
| 111 | MP0005377_hearing/vestibular/ear_phenot | 0.69345290 |
| 112 | MP0003878_abnormal_ear_physiology | 0.69345290 |
| 113 | MP0003861_abnormal_nervous_system | 0.67903945 |
| 114 | MP0002163_abnormal_gland_morphology | 0.67553441 |
| 115 | MP0005253_abnormal_eye_physiology | 0.66155799 |
| 116 | MP0002229_neurodegeneration | 0.63860731 |
| 117 | MP0003329_amyloid_beta_deposits | 0.63684057 |
| 118 | MP0000538_abnormal_urinary_bladder | 0.63496237 |
| 119 | MP0003633_abnormal_nervous_system | 0.61309075 |
| 120 | MP0001664_abnormal_digestion | 0.60353103 |
| 121 | MP0005535_abnormal_body_temperature | 0.60319529 |
| 122 | MP0002277_abnormal_respiratory_mucosa | 0.59736569 |
| 123 | MP0002069_abnormal_eating/drinking_beha | 0.57256115 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Abnormal respiratory motile cilium physiology (HP:0012261) | 7.74928261 |
| 2 | Abnormal respiratory motile cilium morphology (HP:0005938) | 7.71698798 |
| 3 | Abnormal respiratory epithelium morphology (HP:0012253) | 7.71698798 |
| 4 | Abnormal ciliary motility (HP:0012262) | 6.58615334 |
| 5 | Rhinitis (HP:0012384) | 6.37823743 |
| 6 | Chronic bronchitis (HP:0004469) | 5.26888818 |
| 7 | Infertility (HP:0000789) | 4.82424634 |
| 8 | Nephronophthisis (HP:0000090) | 4.38052727 |
| 9 | Focal motor seizures (HP:0011153) | 3.87326067 |
| 10 | Nasal polyposis (HP:0100582) | 3.61307802 |
| 11 | Medial flaring of the eyebrow (HP:0010747) | 3.58038591 |
| 12 | Chronic hepatic failure (HP:0100626) | 3.48888958 |
| 13 | Bronchiectasis (HP:0002110) | 3.39861204 |
| 14 | Abnormality of the renal medulla (HP:0100957) | 3.35526413 |
| 15 | Occipital encephalocele (HP:0002085) | 3.14898513 |
| 16 | Atonic seizures (HP:0010819) | 3.05414945 |
| 17 | Molar tooth sign on MRI (HP:0002419) | 3.03274498 |
| 18 | Abnormality of midbrain morphology (HP:0002418) | 3.03274498 |
| 19 | Tubulointerstitial nephritis (HP:0001970) | 2.85436808 |
| 20 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 2.83104534 |
| 21 | Cystic liver disease (HP:0006706) | 2.80219045 |
| 22 | Abnormality of the nasal mucosa (HP:0000433) | 2.77870272 |
| 23 | Bronchitis (HP:0012387) | 2.77857033 |
| 24 | Gait imbalance (HP:0002141) | 2.77741048 |
| 25 | Febrile seizures (HP:0002373) | 2.74358697 |
| 26 | Epileptic encephalopathy (HP:0200134) | 2.72876446 |
| 27 | Congenital primary aphakia (HP:0007707) | 2.63903407 |
| 28 | Progressive cerebellar ataxia (HP:0002073) | 2.61864797 |
| 29 | Focal seizures (HP:0007359) | 2.58499959 |
| 30 | Hyperventilation (HP:0002883) | 2.52062024 |
| 31 | Retinal dysplasia (HP:0007973) | 2.50270974 |
| 32 | Anencephaly (HP:0002323) | 2.47388170 |
| 33 | Nephrogenic diabetes insipidus (HP:0009806) | 2.42702022 |
| 34 | Abnormal rod and cone electroretinograms (HP:0008323) | 2.37876397 |
| 35 | Decreased circulating renin level (HP:0003351) | 2.27091915 |
| 36 | Limb dystonia (HP:0002451) | 2.26821693 |
| 37 | Sclerocornea (HP:0000647) | 2.21574470 |
| 38 | Genital tract atresia (HP:0001827) | 2.19949294 |
| 39 | Myokymia (HP:0002411) | 2.19244623 |
| 40 | Recurrent sinusitis (HP:0011108) | 2.17178170 |
| 41 | Aplasia/Hypoplasia of the lens (HP:0008063) | 2.17021969 |
| 42 | Tubulointerstitial abnormality (HP:0001969) | 2.14462797 |
| 43 | Vaginal atresia (HP:0000148) | 2.14116033 |
| 44 | Pancreatic fibrosis (HP:0100732) | 2.13178194 |
| 45 | Male pseudohermaphroditism (HP:0000037) | 2.12705381 |
| 46 | Absence seizures (HP:0002121) | 2.11275493 |
| 47 | Recurrent otitis media (HP:0000403) | 2.09293856 |
| 48 | Postaxial hand polydactyly (HP:0001162) | 2.08402588 |
| 49 | Aplasia/Hypoplasia of the spleen (HP:0010451) | 2.07335036 |
| 50 | Male infertility (HP:0003251) | 2.05579893 |
| 51 | Amblyopia (HP:0000646) | 2.03902700 |
| 52 | Asplenia (HP:0001746) | 2.01674449 |
| 53 | Congenital hepatic fibrosis (HP:0002612) | 2.01570497 |
| 54 | Postaxial foot polydactyly (HP:0001830) | 2.00981144 |
| 55 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 10.5810546 |
| 56 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 10.3431798 |
| 57 | Absent/shortened dynein arms (HP:0200106) | 10.3431798 |
| 58 | Polydipsia (HP:0001959) | 1.98139460 |
| 59 | Abnormal drinking behavior (HP:0030082) | 1.98139460 |
| 60 | Hemiparesis (HP:0001269) | 1.97745102 |
| 61 | Gaze-evoked nystagmus (HP:0000640) | 1.95914316 |
| 62 | Acute necrotizing encephalopathy (HP:0006965) | 1.95332966 |
| 63 | True hermaphroditism (HP:0010459) | 1.92346716 |
| 64 | Poor coordination (HP:0002370) | 1.91368511 |
| 65 | Bony spicule pigmentary retinopathy (HP:0007737) | 1.89975476 |
| 66 | Abnormal hair whorl (HP:0010721) | 1.89942645 |
| 67 | Renal dysplasia (HP:0000110) | 1.89863831 |
| 68 | Optic disc pallor (HP:0000543) | 1.88803576 |
| 69 | Dialeptic seizures (HP:0011146) | 1.87883171 |
| 70 | Hypothermia (HP:0002045) | 1.87387971 |
| 71 | Absent speech (HP:0001344) | 1.85683872 |
| 72 | Oculomotor apraxia (HP:0000657) | 1.85067196 |
| 73 | Stage 5 chronic kidney disease (HP:0003774) | 1.85061617 |
| 74 | Atelectasis (HP:0100750) | 1.84310131 |
| 75 | Tubular atrophy (HP:0000092) | 1.84287716 |
| 76 | Chronic otitis media (HP:0000389) | 1.82954816 |
| 77 | Hyperactive renin-angiotensin system (HP:0000841) | 1.78832174 |
| 78 | Decreased central vision (HP:0007663) | 1.77341456 |
| 79 | Abnormality of the renal cortex (HP:0011035) | 1.75691574 |
| 80 | Dyschromatopsia (HP:0007641) | 1.73540758 |
| 81 | Progressive macrocephaly (HP:0004481) | 1.73432197 |
| 82 | Type II lissencephaly (HP:0007260) | 1.73127468 |
| 83 | Inability to walk (HP:0002540) | 1.71130257 |
| 84 | Choroideremia (HP:0001139) | 1.70699684 |
| 85 | Lissencephaly (HP:0001339) | 1.70460337 |
| 86 | Abnormality of macular pigmentation (HP:0008002) | 1.66962462 |
| 87 | Impulsivity (HP:0100710) | 1.65748016 |
| 88 | Furrowed tongue (HP:0000221) | 1.65513961 |
| 89 | Progressive inability to walk (HP:0002505) | 1.65245212 |
| 90 | Narrow forehead (HP:0000341) | 1.64358819 |
| 91 | Agitation (HP:0000713) | 1.63706446 |
| 92 | Abnormality of permanent molar morphology (HP:0011071) | 1.63285857 |
| 93 | Abnormality of the dental root (HP:0006486) | 1.63285857 |
| 94 | Taurodontia (HP:0000679) | 1.63285857 |
| 95 | Gonadotropin excess (HP:0000837) | 1.62591947 |
| 96 | Hip dysplasia (HP:0001385) | 1.62131809 |
| 97 | Abnormal spermatogenesis (HP:0008669) | 1.61504774 |
| 98 | Generalized tonic-clonic seizures (HP:0002069) | 1.60795260 |
| 99 | Supernumerary spleens (HP:0009799) | 1.60728413 |
| 100 | Median cleft lip (HP:0000161) | 1.60719141 |
| 101 | Sleep apnea (HP:0010535) | 1.60714237 |
| 102 | Preaxial hand polydactyly (HP:0001177) | 1.60560572 |
| 103 | Broad-based gait (HP:0002136) | 1.58381181 |
| 104 | Absent eyebrow (HP:0002223) | 1.58016925 |
| 105 | Abnormal mitochondria in muscle tissue (HP:0008316) | 1.57678895 |
| 106 | Fibular hypoplasia (HP:0003038) | 1.55977971 |
| 107 | Retinitis pigmentosa (HP:0000510) | 1.55794385 |
| 108 | Chronic sinusitis (HP:0011109) | 1.55793827 |
| 109 | Visual hallucinations (HP:0002367) | 1.55754533 |
| 110 | Abnormality of the dental pulp (HP:0006479) | 1.55125673 |
| 111 | Failure to thrive in infancy (HP:0001531) | 1.55082841 |
| 112 | Pancreatic cysts (HP:0001737) | 1.54977909 |
| 113 | Aplasia/Hypoplasia of the tongue (HP:0010295) | 1.54813078 |
| 114 | Polyphagia (HP:0002591) | 1.54260220 |
| 115 | Abnormality of molar morphology (HP:0011070) | 1.54007676 |
| 116 | Abnormality of molar (HP:0011077) | 1.54007676 |
| 117 | Abnormality of renin-angiotensin system (HP:0000847) | 1.53240349 |
| 118 | Hyperaldosteronism (HP:0000859) | 1.52496679 |
| 119 | Sensory axonal neuropathy (HP:0003390) | 1.52015797 |
| 120 | Fetal akinesia sequence (HP:0001989) | 1.51291026 |
| 121 | Abnormal biliary tract physiology (HP:0012439) | 1.50864533 |
| 122 | Bile duct proliferation (HP:0001408) | 1.50864533 |
| 123 | Congenital stationary night blindness (HP:0007642) | 1.50849902 |
| 124 | Abnormality of the labia minora (HP:0012880) | 1.50250260 |
| 125 | Aplasia/Hypoplasia of the tibia (HP:0005772) | 1.49577984 |
| 126 | Renal salt wasting (HP:0000127) | 1.49145054 |
| 127 | Abnormality of the lower motor neuron (HP:0002366) | 1.49018052 |
| 128 | Nephropathy (HP:0000112) | 1.48332376 |
| 129 | Short tibia (HP:0005736) | 1.48268969 |
| 130 | Polyuria (HP:0000103) | 1.47864308 |
| 131 | Specific learning disability (HP:0001328) | 1.47744573 |
| 132 | Hypoplasia of the brainstem (HP:0002365) | 1.47499714 |
| 133 | Aplasia/Hypoplasia of the brainstem (HP:0007362) | 1.47499714 |
| 134 | Tubulointerstitial fibrosis (HP:0005576) | 1.46894899 |
| 135 | Neurofibrillary tangles (HP:0002185) | 1.45606460 |
| 136 | Pachygyria (HP:0001302) | 1.39464599 |
| 137 | Concave nail (HP:0001598) | 1.38991642 |
| 138 | Labial hypoplasia (HP:0000066) | 1.38276240 |
| 139 | Prominent nasal bridge (HP:0000426) | 1.37024383 |
| 140 | Aganglionic megacolon (HP:0002251) | 1.36658717 |
| 141 | Drooling (HP:0002307) | 1.35647413 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | PDK3 | 5.51180264 |
| 2 | PDK4 | 5.51180264 |
| 3 | CASK | 3.80007012 |
| 4 | PDK2 | 3.62571385 |
| 5 | PNCK | 3.42795579 |
| 6 | TESK1 | 3.36999623 |
| 7 | PRKD3 | 2.84023037 |
| 8 | NTRK3 | 2.48648335 |
| 9 | RIPK4 | 2.47649319 |
| 10 | PTK2B | 2.31254625 |
| 11 | MAP2K7 | 2.31161384 |
| 12 | ICK | 2.29047948 |
| 13 | MAP3K12 | 1.98483425 |
| 14 | MAP3K4 | 1.96366545 |
| 15 | WNK4 | 1.91192102 |
| 16 | EPHA4 | 1.87451665 |
| 17 | STK39 | 1.83963870 |
| 18 | MARK1 | 1.67149653 |
| 19 | FRK | 1.57373836 |
| 20 | MAPK13 | 1.55119767 |
| 21 | BMPR1B | 1.45469340 |
| 22 | PLK2 | 1.45209943 |
| 23 | TNIK | 1.43377023 |
| 24 | BMPR2 | 1.41263107 |
| 25 | GRK5 | 1.38481692 |
| 26 | CAMKK2 | 1.36560084 |
| 27 | TLK1 | 1.36095150 |
| 28 | NTRK2 | 1.27625543 |
| 29 | PAK3 | 1.26254010 |
| 30 | MKNK2 | 1.17254172 |
| 31 | MST4 | 1.13403136 |
| 32 | MINK1 | 1.13156916 |
| 33 | MAP2K4 | 1.10119719 |
| 34 | DYRK3 | 1.09474590 |
| 35 | GRK7 | 1.08427358 |
| 36 | GRK1 | 1.08136019 |
| 37 | AKT3 | 1.06438733 |
| 38 | PRKCG | 1.06050972 |
| 39 | MUSK | 1.04990245 |
| 40 | CAMKK1 | 1.04978031 |
| 41 | DAPK2 | 1.03357039 |
| 42 | ARAF | 1.01543425 |
| 43 | CAMK2B | 1.00698413 |
| 44 | STK38 | 1.00014512 |
| 45 | CAMK2A | 0.97753996 |
| 46 | SIK2 | 0.95704712 |
| 47 | BRAF | 0.92956198 |
| 48 | STK16 | 0.92433567 |
| 49 | MAP3K11 | 0.87621192 |
| 50 | NME1 | 0.86548350 |
| 51 | DAPK1 | 0.83669803 |
| 52 | WNK1 | 0.82830188 |
| 53 | YES1 | 0.81286571 |
| 54 | PRKCH | 0.81089854 |
| 55 | STK11 | 0.79608623 |
| 56 | CAMK1 | 0.77796479 |
| 57 | MAP3K9 | 0.76167035 |
| 58 | MAPK15 | 0.75851600 |
| 59 | ACVR1B | 0.75817537 |
| 60 | INSRR | 0.72611995 |
| 61 | PRKCI | 0.70638351 |
| 62 | CCNB1 | 0.70230180 |
| 63 | IRAK1 | 0.69457860 |
| 64 | CDK19 | 0.68126564 |
| 65 | CDK5 | 0.64806559 |
| 66 | MAP4K2 | 0.61604684 |
| 67 | SIK3 | 0.61355925 |
| 68 | CAMK1D | 0.60339081 |
| 69 | PDK1 | 0.58838004 |
| 70 | FES | 0.57372025 |
| 71 | NTRK1 | 0.57165879 |
| 72 | PRPF4B | 0.56031845 |
| 73 | MARK2 | 0.55713717 |
| 74 | DYRK1B | 0.55315032 |
| 75 | NUAK1 | 0.54421217 |
| 76 | ERBB2 | 0.52917021 |
| 77 | CSNK1E | 0.52379100 |
| 78 | UHMK1 | 0.52156595 |
| 79 | CAMK2D | 0.52108214 |
| 80 | ADRBK2 | 0.50496023 |
| 81 | CDK3 | 0.50201724 |
| 82 | WEE1 | 0.50055507 |
| 83 | WNK3 | 0.48736249 |
| 84 | PKN1 | 0.47836276 |
| 85 | STK38L | 0.47786943 |
| 86 | DYRK2 | 0.47667086 |
| 87 | EPHB2 | 0.47647585 |
| 88 | DYRK1A | 0.47056149 |
| 89 | CAMK4 | 0.45399082 |
| 90 | KSR1 | 0.45249089 |
| 91 | CDK18 | 0.44451724 |
| 92 | CAMK2G | 0.44441550 |
| 93 | PAK6 | 0.44395005 |
| 94 | OXSR1 | 0.44129492 |
| 95 | PRKCE | 0.44066998 |
| 96 | CDK14 | 0.43967058 |
| 97 | ZAK | 0.43905810 |
| 98 | ERBB3 | 0.42440425 |
| 99 | PDPK1 | 0.41745805 |
| 100 | MAPKAPK5 | 0.41563839 |
| 101 | RPS6KA2 | 0.41411276 |
| 102 | EPHA2 | 0.40707398 |
| 103 | CDK15 | 0.40650364 |
| 104 | PRKCD | 0.40457968 |
| 105 | PRKCA | 0.40426866 |
| 106 | ADRBK1 | 0.38213604 |
| 107 | SGK3 | 0.37116280 |
| 108 | FGR | 0.36765671 |
| 109 | PRKCZ | 0.36240931 |
| 110 | CDK11A | 0.36126632 |
| 111 | FGFR2 | 0.35528256 |
| 112 | CAMK1G | 0.34356197 |
| 113 | RPS6KA3 | 0.33989797 |
| 114 | PINK1 | 0.33738008 |
| 115 | SGK494 | 0.32797521 |
| 116 | SGK223 | 0.32797521 |
| 117 | CSNK1A1 | 0.32649922 |
| 118 | TIE1 | 0.31670184 |
| 119 | PRKACA | 0.30930130 |
| 120 | STK24 | 0.30819222 |
| 121 | PRKCQ | 0.30094968 |
| 122 | ABL2 | 0.29735357 |
| 123 | AURKA | 0.29263993 |
| 124 | PHKG1 | 0.29173392 |
| 125 | PHKG2 | 0.29173392 |
| 126 | PLK4 | 0.28891124 |
| 127 | IRAK2 | 0.28782040 |
| 128 | PRKDC | 0.27339811 |
| 129 | VRK1 | 0.26655817 |
| 130 | SGK2 | 0.26632958 |
| 131 | MKNK1 | 0.26187457 |
| 132 | PRKG1 | 0.25913966 |
| 133 | CSNK1G2 | 0.25535168 |
| 134 | TYRO3 | 0.23707700 |
| 135 | NEK6 | 0.23326786 |
| 136 | BCR | 0.22013894 |
| 137 | SGK1 | 0.21576775 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Nicotine addiction_Homo sapiens_hsa05033 | 4.10386650 |
| 2 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 2.79826519 |
| 3 | Amphetamine addiction_Homo sapiens_hsa05031 | 2.74419877 |
| 4 | Olfactory transduction_Homo sapiens_hsa04740 | 2.69642816 |
| 5 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.64690473 |
| 6 | Taste transduction_Homo sapiens_hsa04742 | 2.61689698 |
| 7 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 2.54335462 |
| 8 | Long-term potentiation_Homo sapiens_hsa04720 | 2.49079165 |
| 9 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 2.44189597 |
| 10 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 2.42479277 |
| 11 | Huntingtons disease_Homo sapiens_hsa05016 | 2.29107897 |
| 12 | Morphine addiction_Homo sapiens_hsa05032 | 2.27985638 |
| 13 | Glutamatergic synapse_Homo sapiens_hsa04724 | 2.22275105 |
| 14 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 2.21147894 |
| 15 | Circadian entrainment_Homo sapiens_hsa04713 | 2.20641710 |
| 16 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 2.03860718 |
| 17 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.97191933 |
| 18 | Alzheimers disease_Homo sapiens_hsa05010 | 1.96495918 |
| 19 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 1.95982395 |
| 20 | Parkinsons disease_Homo sapiens_hsa05012 | 1.93358182 |
| 21 | Renin secretion_Homo sapiens_hsa04924 | 1.89942707 |
| 22 | GABAergic synapse_Homo sapiens_hsa04727 | 1.88991721 |
| 23 | Dopaminergic synapse_Homo sapiens_hsa04728 | 1.87599962 |
| 24 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.84287992 |
| 25 | Insulin secretion_Homo sapiens_hsa04911 | 1.76558900 |
| 26 | Salivary secretion_Homo sapiens_hsa04970 | 1.76368940 |
| 27 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 1.74724603 |
| 28 | Histidine metabolism_Homo sapiens_hsa00340 | 1.73014967 |
| 29 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 1.72321429 |
| 30 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.70973984 |
| 31 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 1.56670262 |
| 32 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 1.50202682 |
| 33 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 1.46852880 |
| 34 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.45494829 |
| 35 | Cocaine addiction_Homo sapiens_hsa05030 | 1.41396660 |
| 36 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.38045916 |
| 37 | Tyrosine metabolism_Homo sapiens_hsa00350 | 1.37650793 |
| 38 | Phototransduction_Homo sapiens_hsa04744 | 1.36438779 |
| 39 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 1.34298729 |
| 40 | Long-term depression_Homo sapiens_hsa04730 | 1.33161736 |
| 41 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 1.33045307 |
| 42 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.26293509 |
| 43 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.26017438 |
| 44 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 1.25211332 |
| 45 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 1.22980238 |
| 46 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 1.21327898 |
| 47 | Retinol metabolism_Homo sapiens_hsa00830 | 1.21258850 |
| 48 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.19657199 |
| 49 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.16539157 |
| 50 | Oocyte meiosis_Homo sapiens_hsa04114 | 1.15107669 |
| 51 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.12208551 |
| 52 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 1.11192715 |
| 53 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 1.08298602 |
| 54 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 1.06208691 |
| 55 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.04692603 |
| 56 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 1.03441927 |
| 57 | Protein export_Homo sapiens_hsa03060 | 1.03005273 |
| 58 | cAMP signaling pathway_Homo sapiens_hsa04024 | 1.00702511 |
| 59 | Axon guidance_Homo sapiens_hsa04360 | 0.99519018 |
| 60 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 0.99087384 |
| 61 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.98567248 |
| 62 | Basal transcription factors_Homo sapiens_hsa03022 | 0.98138467 |
| 63 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.96885303 |
| 64 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.95194774 |
| 65 | Peroxisome_Homo sapiens_hsa04146 | 0.94065303 |
| 66 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.91956383 |
| 67 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.91748114 |
| 68 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.88769123 |
| 69 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.88176996 |
| 70 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 0.87309129 |
| 71 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.87276483 |
| 72 | Gap junction_Homo sapiens_hsa04540 | 0.85382698 |
| 73 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.84103949 |
| 74 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.83886495 |
| 75 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.81269183 |
| 76 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.80807481 |
| 77 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.79405990 |
| 78 | Ribosome_Homo sapiens_hsa03010 | 0.78306130 |
| 79 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.77982719 |
| 80 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.75719598 |
| 81 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.75531760 |
| 82 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.74243535 |
| 83 | Melanogenesis_Homo sapiens_hsa04916 | 0.73173364 |
| 84 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.73029583 |
| 85 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.72413050 |
| 86 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.71232347 |
| 87 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.69514008 |
| 88 | Circadian rhythm_Homo sapiens_hsa04710 | 0.68779371 |
| 89 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.67840107 |
| 90 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.67356596 |
| 91 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.66664143 |
| 92 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.64715577 |
| 93 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.63909743 |
| 94 | Mineral absorption_Homo sapiens_hsa04978 | 0.61359097 |
| 95 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.59577435 |
| 96 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.58430203 |
| 97 | Alcoholism_Homo sapiens_hsa05034 | 0.55933293 |
| 98 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.55861644 |
| 99 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.55855269 |
| 100 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.55419837 |
| 101 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.53163231 |
| 102 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.52723422 |
| 103 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.51481352 |
| 104 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.51061503 |
| 105 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.50964857 |
| 106 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.50124439 |
| 107 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.49445725 |
| 108 | Phagosome_Homo sapiens_hsa04145 | 0.49131075 |
| 109 | RNA polymerase_Homo sapiens_hsa03020 | 0.49110627 |
| 110 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.48550405 |
| 111 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.48200033 |
| 112 | Purine metabolism_Homo sapiens_hsa00230 | 0.48169147 |
| 113 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.47141190 |
| 114 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.46810572 |
| 115 | ABC transporters_Homo sapiens_hsa02010 | 0.45962511 |
| 116 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.43050953 |
| 117 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.43024682 |
| 118 | Metabolic pathways_Homo sapiens_hsa01100 | 0.42526659 |
| 119 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.42243932 |
| 120 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.40974804 |
| 121 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.40475225 |
| 122 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 0.39348101 |
| 123 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.37631427 |
| 124 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.37357681 |
| 125 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.37051659 |
| 126 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.35487036 |
| 127 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.33644631 |
| 128 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.31819282 |
| 129 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.31774149 |
| 130 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.30802943 |
| 131 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.28650350 |
| 132 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.27665437 |
| 133 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.26980031 |
| 134 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.26941454 |
| 135 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.24782462 |
| 136 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.24260651 |
| 137 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.23244274 |
| 138 | Glioma_Homo sapiens_hsa05214 | 0.22719942 |
| 139 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.21396567 |

