TCTE3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm motility (GO:0030317)9.95126527
2axonemal dynein complex assembly (GO:0070286)9.40412413
3binding of sperm to zona pellucida (GO:0007339)9.28639090
4epithelial cilium movement (GO:0003351)9.26033282
5acrosome reaction (GO:0007340)9.03499921
6spermatid development (GO:0007286)7.96399133
7spermatid nucleus differentiation (GO:0007289)7.82190135
8epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.44086938
9single fertilization (GO:0007338)7.43731820
10cilium movement (GO:0003341)7.34611643
11male meiosis (GO:0007140)6.70902250
12piRNA metabolic process (GO:0034587)6.48855210
13DNA unwinding involved in DNA replication (GO:0006268)6.18315328
14synaptonemal complex organization (GO:0070193)6.09052787
15synaptonemal complex assembly (GO:0007130)6.01656339
16sperm capacitation (GO:0048240)5.88035842
17fertilization (GO:0009566)5.80251499
18microtubule depolymerization (GO:0007019)5.65187168
19regulation of cilium movement (GO:0003352)5.47842761
20single strand break repair (GO:0000012)5.07029642
21sexual reproduction (GO:0019953)5.05977825
22centriole assembly (GO:0098534)4.97566504
23calcium ion-dependent exocytosis (GO:0017156)4.96941013
24spermatogenesis (GO:0007283)4.88090619
25male gamete generation (GO:0048232)4.86537517
26cell recognition (GO:0008037)4.85414467
27centriole replication (GO:0007099)4.63450506
28organic cation transport (GO:0015695)4.58365364
29DNA topological change (GO:0006265)4.54831800
30cellular process involved in reproduction in multicellular organism (GO:0022412)4.51015030
31gamete generation (GO:0007276)4.49327818
32regulation of memory T cell differentiation (GO:0043380)4.45830588
33germ cell development (GO:0007281)4.38596426
34attachment of spindle microtubules to kinetochore (GO:0008608)4.37687649
35negative regulation of inclusion body assembly (GO:0090084)4.37371123
36mitochondrial DNA replication (GO:0006264)4.34281573
37DNA methylation involved in gamete generation (GO:0043046)4.32492340
38chromosome organization involved in meiosis (GO:0070192)4.29074178
39meiotic nuclear division (GO:0007126)4.23013560
40glycerol ether metabolic process (GO:0006662)4.18876224
41resolution of meiotic recombination intermediates (GO:0000712)4.16196915
42ventricular system development (GO:0021591)4.03502998
43regulation of inclusion body assembly (GO:0090083)3.98539728
44histone H2A acetylation (GO:0043968)3.96806176
45protein K11-linked deubiquitination (GO:0035871)3.96627102
46monoubiquitinated protein deubiquitination (GO:0035520)3.91984670
47ether metabolic process (GO:0018904)3.85582791
48fatty acid elongation (GO:0030497)3.84119293
49regulation of DNA endoreduplication (GO:0032875)3.82657051
50rRNA transcription (GO:0009303)3.82438660
51negative regulation of DNA-dependent DNA replication (GO:2000104)3.79346025
52negative regulation of T-helper cell differentiation (GO:0045623)3.69104682
53negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.69104682
54negative regulation of DNA recombination (GO:0045910)3.68705967
55male meiosis I (GO:0007141)3.65446837
56mRNA cleavage (GO:0006379)3.61934711
57chaperone-mediated protein complex assembly (GO:0051131)3.58325203
58negative regulation of B cell apoptotic process (GO:0002903)3.57521348
59multicellular organismal reproductive process (GO:0048609)3.50362493
60hematopoietic stem cell differentiation (GO:0060218)3.49500254
61negative regulation of mRNA processing (GO:0050686)3.49126249
62regulation of centrosome duplication (GO:0010824)3.47450510
63negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.47438784
64metaphase plate congression (GO:0051310)3.45499967
65peptidyl-threonine dephosphorylation (GO:0035970)3.42866245
66negative regulation of Rho protein signal transduction (GO:0035024)3.39317964
67mitotic metaphase plate congression (GO:0007080)3.37926872
68urate metabolic process (GO:0046415)3.36312305
69germinal center formation (GO:0002467)3.31102499
70nuclear pore organization (GO:0006999)3.31049740
71peptidyl-histidine modification (GO:0018202)3.30160754
72regulation of centrosome cycle (GO:0046605)3.28096910
73DNA replication initiation (GO:0006270)3.27404010
74negative regulation of mRNA metabolic process (GO:1903312)3.27385166
75replication fork processing (GO:0031297)3.25097889
76microtubule polymerization or depolymerization (GO:0031109)3.23329508
77positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)3.23057030
78mitochondrial DNA metabolic process (GO:0032042)3.19809258
79poly(A)+ mRNA export from nucleus (GO:0016973)3.17702828
80microtubule severing (GO:0051013)3.16325846
81pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.13746122
82histone monoubiquitination (GO:0010390)3.12276694
83regulation of heat generation (GO:0031650)3.11832358
84termination of RNA polymerase II transcription (GO:0006369)3.11288319
85macroautophagy (GO:0016236)3.10319850
86definitive hemopoiesis (GO:0060216)3.08789728
87maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.07865291
88regulation of microtubule-based movement (GO:0060632)3.06863175
89DNA-dependent DNA replication (GO:0006261)3.05709818
90mRNA splice site selection (GO:0006376)3.02600869
91meiotic chromosome segregation (GO:0045132)3.00091016
92cell wall macromolecule catabolic process (GO:0016998)20.2783036
93cell wall macromolecule metabolic process (GO:0044036)20.2783036
94meiotic cell cycle (GO:0051321)2.99981799
95mitotic G2/M transition checkpoint (GO:0044818)2.98306304
96negative regulation of RNA splicing (GO:0033119)2.98287439
97DNA replication checkpoint (GO:0000076)2.95237689
98meiosis I (GO:0007127)2.93687106
99DNA duplex unwinding (GO:0032508)2.92579928
100mitotic G2 DNA damage checkpoint (GO:0007095)2.92503704
101DNA geometric change (GO:0032392)2.91002515
102CENP-A containing nucleosome assembly (GO:0034080)2.90683681
103base-excision repair, AP site formation (GO:0006285)2.90618819
104innate immune response in mucosa (GO:0002227)2.89800600
105V(D)J recombination (GO:0033151)2.89225546
106transcription from RNA polymerase III promoter (GO:0006383)2.89126092
107histone H2B ubiquitination (GO:0033523)2.88920660
108DNA replication-dependent nucleosome organization (GO:0034723)2.88832885
109DNA replication-dependent nucleosome assembly (GO:0006335)2.88832885
110regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.86920028
111chromatin remodeling at centromere (GO:0031055)2.86163028
112regulation of mitotic spindle checkpoint (GO:1903504)2.83337070
113regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.83337070
114pseudouridine synthesis (GO:0001522)2.83067508
115nucleus organization (GO:0006997)2.82708931
116regulation of centriole replication (GO:0046599)2.82420471
117mRNA export from nucleus (GO:0006406)2.81686083
118histone ubiquitination (GO:0016574)2.81483428
119nonmotile primary cilium assembly (GO:0035058)2.80246384
120alditol metabolic process (GO:0019400)2.79522191
121translesion synthesis (GO:0019985)2.79183086
122RNA export from nucleus (GO:0006405)2.79075651
123single-organism membrane fusion (GO:0044801)2.78631287
124polyol catabolic process (GO:0046174)2.76964441
125cilium organization (GO:0044782)2.76763931
126chromosome condensation (GO:0030261)2.76479252
127multicellular organismal development (GO:0007275)2.76403314
128preassembly of GPI anchor in ER membrane (GO:0016254)2.76230731
129sister chromatid segregation (GO:0000819)2.75989592
130postreplication repair (GO:0006301)2.74570795
131positive regulation of osteoclast differentiation (GO:0045672)2.74089297
132regulation of T-helper 2 cell differentiation (GO:0045628)2.74000441
133DNA ligation (GO:0006266)2.73817920
134protein K6-linked ubiquitination (GO:0085020)2.72525019
135telomere maintenance via telomerase (GO:0007004)2.72252820
136cilium assembly (GO:0042384)2.72124371
137kinetochore organization (GO:0051383)2.71659684
138cellular response to glucose starvation (GO:0042149)2.71577646
139positive regulation of macrophage activation (GO:0043032)2.71577307
140somatic diversification of immune receptors via somatic mutation (GO:0002566)2.70854553
141somatic hypermutation of immunoglobulin genes (GO:0016446)2.70854553
142axoneme assembly (GO:0035082)2.70796794
143intraciliary transport (GO:0042073)2.70177531
144negative regulation of viral entry into host cell (GO:0046597)2.69913305
145establishment of chromosome localization (GO:0051303)2.69778272
146nucleosome assembly (GO:0006334)2.69323663
147carnitine transport (GO:0015879)2.69115324
148amino-acid betaine transport (GO:0015838)2.69115324
149deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.68009377
150IMP biosynthetic process (GO:0006188)2.67856497
151gene silencing by RNA (GO:0031047)2.67625193
152glycerol metabolic process (GO:0006071)2.67588880
153growth hormone receptor signaling pathway (GO:0060396)2.67158468
154seminiferous tubule development (GO:0072520)2.67089367
155negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.66026620
156pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.65647666
157pyrimidine nucleotide catabolic process (GO:0006244)2.65063498
158regulation of spindle checkpoint (GO:0090231)2.64895513
159regulation of double-strand break repair via homologous recombination (GO:0010569)2.64520139
160granulocyte differentiation (GO:0030851)2.63473661
161intra-S DNA damage checkpoint (GO:0031573)2.63404305
162sister chromatid cohesion (GO:0007062)2.62898663
163protein localization to cilium (GO:0061512)2.61881380
164cellular component assembly involved in morphogenesis (GO:0010927)2.60723543
165regulation of meiosis I (GO:0060631)2.60334805
166histone exchange (GO:0043486)2.60295676
167DNA double-strand break processing (GO:0000729)2.59812117
168mitotic nuclear envelope disassembly (GO:0007077)2.58807199
169cilium morphogenesis (GO:0060271)2.57433577
170microtubule-based movement (GO:0007018)2.57428285
171DNA synthesis involved in DNA repair (GO:0000731)2.57380698
172carnitine transmembrane transport (GO:1902603)2.57183819
173DNA conformation change (GO:0071103)2.56438271
174DNA packaging (GO:0006323)2.55317365
175genitalia morphogenesis (GO:0035112)2.49323179
176meiotic cell cycle process (GO:1903046)2.49247438
177synapsis (GO:0007129)2.48402418
178left/right pattern formation (GO:0060972)2.48179349
179DNA deamination (GO:0045006)2.44707299
180regulation of cytokine production involved in inflammatory response (GO:1900015)2.44524210
181pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.43925208
182nuclear pore complex assembly (GO:0051292)2.37417964
183protein-DNA complex disassembly (GO:0032986)2.33490042
184nucleosome disassembly (GO:0006337)2.33490042
185deoxyribose phosphate biosynthetic process (GO:0046385)2.28406462
186fusion of sperm to egg plasma membrane (GO:0007342)16.2493031
187multicellular organism reproduction (GO:0032504)12.6211908
188plasma membrane fusion (GO:0045026)12.3994392
189cilium or flagellum-dependent cell motility (GO:0001539)11.9032332
190sperm-egg recognition (GO:0035036)11.2571988
191acrosome assembly (GO:0001675)11.1386988
192reproduction (GO:0000003)10.9408769
193motile cilium assembly (GO:0044458)10.3096951
194cell-cell recognition (GO:0009988)10.0971851

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.45024835
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse5.26299745
3E2F7_22180533_ChIP-Seq_HELA_Human5.07271789
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.43813396
5E2F4_17652178_ChIP-ChIP_JURKAT_Human4.42526719
6RBPJ_22232070_ChIP-Seq_NCS_Mouse3.68978023
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.34813506
8FOXM1_23109430_ChIP-Seq_U2OS_Human3.03181835
9CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.02959733
10EST1_17652178_ChIP-ChIP_JURKAT_Human3.02806313
11FLI1_27457419_Chip-Seq_LIVER_Mouse3.01354312
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.92438531
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.86817047
14TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.77904226
15* GABP_17652178_ChIP-ChIP_JURKAT_Human2.76800736
16PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.68747797
17* KAP1_22055183_ChIP-Seq_ESCs_Mouse2.64193311
18NOTCH1_21737748_ChIP-Seq_TLL_Human2.60512201
19VDR_23849224_ChIP-Seq_CD4+_Human2.60289510
20PCGF2_27294783_Chip-Seq_ESCs_Mouse2.59670986
21CBX2_27304074_Chip-Seq_ESCs_Mouse2.59158548
22CREB1_15753290_ChIP-ChIP_HEK293T_Human2.50962326
23CIITA_25753668_ChIP-Seq_RAJI_Human2.49951267
24ELK1_19687146_ChIP-ChIP_HELA_Human2.47528592
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.41960577
26ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.40127853
27CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.32191567
28HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.26821658
29ZFP57_27257070_Chip-Seq_ESCs_Mouse2.23060860
30PADI4_21655091_ChIP-ChIP_MCF-7_Human2.22727674
31EWS_26573619_Chip-Seq_HEK293_Human2.13328218
32YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.11945114
33KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.08972037
34ETS1_20019798_ChIP-Seq_JURKAT_Human2.08166388
35E2F1_21310950_ChIP-Seq_MCF-7_Human2.07272008
36KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse2.06255543
37FOXP3_21729870_ChIP-Seq_TREG_Human2.03984101
38MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.00102055
39FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.98570564
40MYC_18555785_ChIP-Seq_MESCs_Mouse1.97647798
41TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.97227782
42DCP1A_22483619_ChIP-Seq_HELA_Human1.96709041
43RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.95806020
44KDM2B_26808549_Chip-Seq_REH_Human1.95080706
45CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.94275216
46STAT6_21828071_ChIP-Seq_BEAS2B_Human1.94166610
47TAL1_26923725_Chip-Seq_HPCs_Mouse1.91083257
48MYC_19030024_ChIP-ChIP_MESCs_Mouse1.85519124
49* TTF2_22483619_ChIP-Seq_HELA_Human1.83590018
50GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.82426310
51HOXB4_20404135_ChIP-ChIP_EML_Mouse1.81000217
52ZNF274_21170338_ChIP-Seq_K562_Hela1.80304332
53TP63_19390658_ChIP-ChIP_HaCaT_Human1.78761430
54MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.78058706
55PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.77732123
56JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.77480161
57TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.77461890
58WDR5_24793694_ChIP-Seq_LNCAP_Human1.72469844
59PCGF2_27294783_Chip-Seq_NPCs_Mouse1.72248992
60SUZ12_27294783_Chip-Seq_NPCs_Mouse1.72044005
61NFE2_27457419_Chip-Seq_LIVER_Mouse1.70297495
62EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.69094506
63STAT1_17558387_ChIP-Seq_HELA_Human1.66987458
64GATA3_21867929_ChIP-Seq_CD8_Mouse1.65343183
65CRX_20693478_ChIP-Seq_RETINA_Mouse1.64485516
66NELFA_20434984_ChIP-Seq_ESCs_Mouse1.64400320
67ELK4_26923725_Chip-Seq_MESODERM_Mouse1.62654119
68EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.62440581
69MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.61282371
70ESR1_15608294_ChIP-ChIP_MCF-7_Human1.59094856
71ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.57674303
72CMYC_18555785_Chip-Seq_ESCs_Mouse1.56082389
73ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.55514769
74XRN2_22483619_ChIP-Seq_HELA_Human1.55107976
75OCT4_18555785_Chip-Seq_ESCs_Mouse1.52727491
76KDM5A_27292631_Chip-Seq_BREAST_Human1.52726874
77PKCTHETA_26484144_Chip-Seq_BREAST_Human1.50310932
78MYC_19079543_ChIP-ChIP_MESCs_Mouse1.50254018
79VDR_22108803_ChIP-Seq_LS180_Human1.49542510
80ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.49146181
81NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.48369677
82GATA1_26923725_Chip-Seq_HPCs_Mouse1.48115507
83IRF8_22096565_ChIP-ChIP_GC-B_Human1.47554460
84P300_18555785_Chip-Seq_ESCs_Mouse1.47043562
85* GABP_19822575_ChIP-Seq_HepG2_Human1.44757469
86LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.44317537
87EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.43830116
88GATA3_21867929_ChIP-Seq_TH1_Mouse1.42846592
89KLF4_18555785_Chip-Seq_ESCs_Mouse1.42715682
90ELF1_17652178_ChIP-ChIP_JURKAT_Human1.42672846
91KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.41733798
92NANOG_18555785_Chip-Seq_ESCs_Mouse1.40979060
93FLI1_21867929_ChIP-Seq_TH2_Mouse1.40312856
94TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40028888
95SCL_19346495_ChIP-Seq_HPC-7_Human1.39605765
96P53_22387025_ChIP-Seq_ESCs_Mouse1.38949176
97MYCN_18555785_ChIP-Seq_MESCs_Mouse1.38780556
98ERG_20887958_ChIP-Seq_HPC-7_Mouse1.38541974
99POU3F2_20337985_ChIP-ChIP_501MEL_Human1.38086952
100CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.37645981
101IRF1_19129219_ChIP-ChIP_H3396_Human1.37244033
102SOX2_22085726_ChIP-Seq_NPCs_Mouse1.36848979
103EZH2_27294783_Chip-Seq_NPCs_Mouse1.36682936
104MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.36249515
105PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.35905641
106SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.34278530
107ESRRB_18555785_Chip-Seq_ESCs_Mouse1.34076334
108SOX2_16153702_ChIP-ChIP_HESCs_Human1.33718452
109GATA1_22025678_ChIP-Seq_K562_Human1.33604993
110PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.32910422
111EGR1_19374776_ChIP-ChIP_THP-1_Human1.32793321
112MYC_18358816_ChIP-ChIP_MESCs_Mouse1.32327892
113SUZ12_18555785_Chip-Seq_ESCs_Mouse1.32304458
114SOX2_18555785_Chip-Seq_ESCs_Mouse1.32237433
115BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.32140322
116SALL1_21062744_ChIP-ChIP_HESCs_Human1.31626182
117RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.31429590
118TFEB_21752829_ChIP-Seq_HELA_Human1.29699240
119CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.29478076
120SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.28783540
121CTBP2_25329375_ChIP-Seq_LNCAP_Human1.28458303
122CTCF_18555785_Chip-Seq_ESCs_Mouse1.27591634
123STAT3_18555785_Chip-Seq_ESCs_Mouse1.27398592
124MYC_18940864_ChIP-ChIP_HL60_Human1.25266461
125RUNX1_27457419_Chip-Seq_LIVER_Mouse1.23735044
126SMAD1_18555785_Chip-Seq_ESCs_Mouse1.23579487
127THAP11_20581084_ChIP-Seq_MESCs_Mouse1.22074849
128OCT4_21477851_ChIP-Seq_ESCs_Mouse1.20960661
129SOX9_26525672_Chip-Seq_HEART_Mouse1.18664761
130PU1_27457419_Chip-Seq_LIVER_Mouse1.17987105
131ETS1_22383799_ChIP-Seq_G1ME_Mouse1.16894625
132POU5F1_16153702_ChIP-ChIP_HESCs_Human1.16824055
133STAT3_1855785_ChIP-Seq_MESCs_Mouse1.16128407
134NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.15983800
135EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.15341878
136TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.14985852
137POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.14836296
138POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.14479863
139FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13742950
140NMYC_18555785_Chip-Seq_ESCs_Mouse1.12538637
141E2F1_18555785_Chip-Seq_ESCs_Mouse1.11919858
142CBP_20019798_ChIP-Seq_JUKART_Human1.11479620
143IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.11479620
144GF1_26923725_Chip-Seq_HPCs_Mouse1.11462739
145LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse1.11361920
146ZNF263_19887448_ChIP-Seq_K562_Human1.10778182
147SRF_21415370_ChIP-Seq_HL-1_Mouse1.09281206
148NFIB_24661679_ChIP-Seq_LUNG_Mouse1.08920086
149REST_21632747_ChIP-Seq_MESCs_Mouse1.07908401
150* EGR1_23403033_ChIP-Seq_LIVER_Mouse1.07802010
151ZFX_18555785_Chip-Seq_ESCs_Mouse1.07786868
152P53_21459846_ChIP-Seq_SAOS-2_Human1.07300359
153RUNX1_26923725_Chip-Seq_HPCs_Mouse1.06248143
154ZFX_18555785_ChIP-Seq_MESCs_Mouse1.06145389
155E2F1_18555785_ChIP-Seq_MESCs_Mouse1.06104193
156SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.05283126
157FLI1_21867929_ChIP-Seq_CD8_Mouse1.03815489
158EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.03483637
159* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.03193536
160EZH2_22144423_ChIP-Seq_EOC_Human1.03008006
161CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.01839783
162GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.00797052
163GF1B_26923725_Chip-Seq_HPCs_Mouse1.00024443
164E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.99386665
165ESET_19884257_ChIP-Seq_ESCs_Mouse0.99323273
166STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.98540429
167RARA_24833708_ChIP-Seq_LIVER_Mouse0.98352338
168FUS_26573619_Chip-Seq_HEK293_Human0.98346247
169CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.97513614
170IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.96743674
171YY1_21170310_ChIP-Seq_MESCs_Mouse0.96212542
172* SPI1_26923725_Chip-Seq_HPCs_Mouse0.95280105
173FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.93836696
174SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.92360714
175* SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.91919977
176SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.91359707
177MYB_26560356_Chip-Seq_TH2_Human0.91110342
178STAT3_18555785_ChIP-Seq_MESCs_Mouse0.89449429
179CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.88946633
180NFYB_21822215_ChIP-Seq_K562_Human0.88154232
181E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.88082571
182SALL4_22934838_ChIP-ChIP_CD34+_Human0.87261716
183RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.86410266
184TP53_22573176_ChIP-Seq_HFKS_Human0.86393886
185YY1_22570637_ChIP-Seq_MALME-3M_Human0.84869220
186SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.84205538
187RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.82935143
188RAD21_21589869_ChIP-Seq_MESCs_Mouse0.82431837
189SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.81302104
190* FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.80953155

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0003698_abnormal_male_reproductive5.70869510
2* MP0001929_abnormal_gametogenesis5.28386127
3MP0008877_abnormal_DNA_methylation5.09964306
4MP0002138_abnormal_hepatobiliary_system3.65513379
5* MP0002210_abnormal_sex_determination3.47333356
6MP0002653_abnormal_ependyma_morphology3.45565868
7* MP0002161_abnormal_fertility/fecundity3.06426825
8* MP0001145_abnormal_male_reproductive3.02038526
9MP0004147_increased_porphyrin_level2.82935583
10* MP0000653_abnormal_sex_gland2.67590843
11MP0004233_abnormal_muscle_weight2.62865642
12MP0002102_abnormal_ear_morphology2.55973075
13MP0005075_abnormal_melanosome_morpholog2.55460769
14MP0002006_tumorigenesis2.36491015
15MP0002396_abnormal_hematopoietic_system2.35861139
16MP0008058_abnormal_DNA_repair2.31160743
17MP0004381_abnormal_hair_follicle2.24910177
18MP0005670_abnormal_white_adipose2.09895767
19MP0005410_abnormal_fertilization14.2858617
20MP0005645_abnormal_hypothalamus_physiol1.92880702
21MP0010094_abnormal_chromosome_stability1.91295040
22MP0004043_abnormal_pH_regulation1.90357302
23MP0001835_abnormal_antigen_presentation1.84381907
24MP0003718_maternal_effect1.73994593
25MP0002160_abnormal_reproductive_system1.71922021
26MP0008057_abnormal_DNA_replication1.71507373
27MP0008961_abnormal_basal_metabolism1.71285067
28MP0001984_abnormal_olfaction1.67870204
29MP0001542_abnormal_bone_strength1.55064027
30MP0006292_abnormal_olfactory_placode1.44369919
31MP0003221_abnormal_cardiomyocyte_apopto1.42833242
32MP0001849_ear_inflammation1.39622067
33MP0009046_muscle_twitch1.38476621
34MP0002234_abnormal_pharynx_morphology1.36859044
35MP0005451_abnormal_body_composition1.33835532
36MP0005360_urolithiasis1.32022033
37MP0002254_reproductive_system_inflammat1.31801031
38MP0006072_abnormal_retinal_apoptosis1.23561739
39MP0005623_abnormal_meninges_morphology1.20725009
40MP0003890_abnormal_embryonic-extraembry1.19962711
41MP0000685_abnormal_immune_system1.17834006
42MP0002009_preneoplasia1.17362823
43MP0006054_spinal_hemorrhage1.13729219
44MP0003195_calcinosis1.12028024
45MP0004185_abnormal_adipocyte_glucose1.08931675
46MP0003111_abnormal_nucleus_morphology1.08444953
47MP0000350_abnormal_cell_proliferation1.06104099
48MP0002282_abnormal_trachea_morphology1.05634767
49MP0002928_abnormal_bile_duct1.04344291
50MP0002132_abnormal_respiratory_system1.02308533
51MP0005167_abnormal_blood-brain_barrier1.01684695
52MP0000689_abnormal_spleen_morphology0.98785405
53MP0005174_abnormal_tail_pigmentation0.98404999
54MP0005220_abnormal_exocrine_pancreas0.96139261
55MP0002398_abnormal_bone_marrow0.95297771
56MP0005409_darkened_coat_color0.92505466
57MP0001765_abnormal_ion_homeostasis0.90663656
58MP0010307_abnormal_tumor_latency0.90324746
59MP0005647_abnormal_sex_gland0.89667380
60MP0001661_extended_life_span0.88962080
61MP0005646_abnormal_pituitary_gland0.87910212
62MP0002277_abnormal_respiratory_mucosa0.85692101
63MP0001853_heart_inflammation0.85479051
64MP0006036_abnormal_mitochondrial_physio0.84780055
65MP0002722_abnormal_immune_system0.84779598
66MP0005389_reproductive_system_phenotype0.81450819
67MP0005551_abnormal_eye_electrophysiolog0.81265801
68MP0008789_abnormal_olfactory_epithelium0.79295514
69MP0009703_decreased_birth_body0.73970324
70MP0003011_delayed_dark_adaptation0.73840159
71MP0003763_abnormal_thymus_physiology0.73572710
72MP0001502_abnormal_circadian_rhythm0.73264342
73MP0002269_muscular_atrophy0.72169420
74MP0006276_abnormal_autonomic_nervous0.70419970
75MP0002111_abnormal_tail_morphology0.69663942
76MP0005394_taste/olfaction_phenotype0.69640887
77MP0005499_abnormal_olfactory_system0.69640887
78MP0009333_abnormal_splenocyte_physiolog0.69444787
79MP0005636_abnormal_mineral_homeostasis0.69341680
80MP0001119_abnormal_female_reproductive0.65996707
81MP0006035_abnormal_mitochondrial_morpho0.65992984
82MP0001243_abnormal_dermal_layer0.65248328
83MP0002429_abnormal_blood_cell0.65028801
84MP0003077_abnormal_cell_cycle0.65021416
85MP0005365_abnormal_bile_salt0.63686946
86MP0000647_abnormal_sebaceous_gland0.63643476
87MP0003656_abnormal_erythrocyte_physiolo0.63191417
88MP0002139_abnormal_hepatobiliary_system0.63145697
89MP0000358_abnormal_cell_content/0.63102776
90MP0008770_decreased_survivor_rate0.62615344
91MP0003943_abnormal_hepatobiliary_system0.62222541
92MP0000631_abnormal_neuroendocrine_gland0.62140966
93MP0000716_abnormal_immune_system0.61243427
94MP0000613_abnormal_salivary_gland0.60182121
95MP0003786_premature_aging0.57972105
96MP0001324_abnormal_eye_pigmentation0.57459032
97MP0000015_abnormal_ear_pigmentation0.55569060
98MP0008995_early_reproductive_senescence0.55473970
99MP0004957_abnormal_blastocyst_morpholog0.54711514
100MP0001764_abnormal_homeostasis0.52707054
101MP0004019_abnormal_vitamin_homeostasis0.52408196
102MP0003699_abnormal_female_reproductive0.51428988
103MP0008872_abnormal_physiological_respon0.49474144
104MP0009697_abnormal_copulation0.49072299
105MP0000313_abnormal_cell_death0.48916459
106MP0002971_abnormal_brown_adipose0.47775040
107MP0001730_embryonic_growth_arrest0.47681921
108MP0005319_abnormal_enzyme/_coenzyme0.45354699
109MP0005397_hematopoietic_system_phenotyp0.43073178
110MP0001545_abnormal_hematopoietic_system0.43073178
111MP0000490_abnormal_crypts_of0.42047332
112MP0001293_anophthalmia0.41604809
113MP0005535_abnormal_body_temperature0.40071525
114MP0003693_abnormal_embryo_hatching0.39990428
115MP0005253_abnormal_eye_physiology0.39245860
116MP0001697_abnormal_embryo_size0.38287642
117MP0003633_abnormal_nervous_system0.37740339
118MP0004808_abnormal_hematopoietic_stem0.37079954
119MP0002084_abnormal_developmental_patter0.35973035
120MP0002019_abnormal_tumor_incidence0.35808247
121MP0002163_abnormal_gland_morphology0.35503589
122MP0009115_abnormal_fat_cell0.34263493
123MP0001529_abnormal_vocalization0.34071133
124MP0002405_respiratory_system_inflammati0.33632475
125MP0010352_gastrointestinal_tract_polyps0.31592893
126MP0008007_abnormal_cellular_replicative0.31224000
127MP0005380_embryogenesis_phenotype0.31156727
128MP0001672_abnormal_embryogenesis/_devel0.31156727
129MP0002080_prenatal_lethality0.30741860
130MP0008932_abnormal_embryonic_tissue0.29986374
131MP0003984_embryonic_growth_retardation0.29984164
132MP0004133_heterotaxia0.29925766
133MP0002970_abnormal_white_adipose0.27960425
134MP0003646_muscle_fatigue0.27567589
135MP0002557_abnormal_social/conspecific_i0.26308656
136MP0002088_abnormal_embryonic_growth/wei0.25505811
137MP0002752_abnormal_somatic_nervous0.25154029
138MP0003115_abnormal_respiratory_system0.24973554
139MP0005195_abnormal_posterior_eye0.24910830
140MP0000703_abnormal_thymus_morphology0.24784972
141MP0002085_abnormal_embryonic_tissue0.24057038
142MP0008875_abnormal_xenobiotic_pharmacok0.23038702
143MP0000609_abnormal_liver_physiology0.21143961
144MP0000026_abnormal_inner_ear0.21011442
145MP0005391_vision/eye_phenotype0.20981777
146MP0002166_altered_tumor_susceptibility0.20818316
147MP0004197_abnormal_fetal_growth/weight/0.20766779
148MP0002133_abnormal_respiratory_system0.20219267

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory epithelium morphology (HP:0012253)9.27680118
2Abnormal respiratory motile cilium morphology (HP:0005938)9.27680118
3Abnormal respiratory motile cilium physiology (HP:0012261)8.56564777
4Rhinitis (HP:0012384)7.45817240
5Abnormal ciliary motility (HP:0012262)7.12288721
6Chronic bronchitis (HP:0004469)6.98117736
7Nasal polyposis (HP:0100582)6.24177520
8Abnormality of the nasal mucosa (HP:0000433)5.22019567
9Medial flaring of the eyebrow (HP:0010747)4.75273543
10Infertility (HP:0000789)4.74908787
11Bronchiectasis (HP:0002110)4.35722271
12Congenital primary aphakia (HP:0007707)4.34346834
13Gait imbalance (HP:0002141)4.34182238
14Chronic hepatic failure (HP:0100626)4.19327861
15Bronchitis (HP:0012387)4.01720356
16Acute lymphatic leukemia (HP:0006721)3.97753489
17Tongue fasciculations (HP:0001308)3.94160969
18Nephrogenic diabetes insipidus (HP:0009806)3.80252757
19Muscle fibrillation (HP:0010546)3.69324130
20Panhypogammaglobulinemia (HP:0003139)3.62640129
21B lymphocytopenia (HP:0010976)3.49602176
22Recurrent sinusitis (HP:0011108)3.40794714
23Abnormality of B cell number (HP:0010975)3.39655241
24Chromosomal breakage induced by crosslinking agents (HP:0003221)3.38971915
25Chromsome breakage (HP:0040012)3.34994128
26Poor coordination (HP:0002370)3.30184130
27Clubbing of toes (HP:0100760)3.28909364
28Short middle phalanx of the 5th finger (HP:0004220)3.19237155
29Chronic sinusitis (HP:0011109)3.17380888
30Nephronophthisis (HP:0000090)3.17275816
31Multiple enchondromatosis (HP:0005701)3.11178770
32Methylmalonic acidemia (HP:0002912)3.05470283
33Elevated erythrocyte sedimentation rate (HP:0003565)3.03910885
34Vaginal atresia (HP:0000148)3.02468793
35Large eyes (HP:0001090)2.98497524
36Abnormality of chromosome stability (HP:0003220)2.95693971
37Abnormality of the fingertips (HP:0001211)2.94131662
38Severe combined immunodeficiency (HP:0004430)2.91959122
39Chronic otitis media (HP:0000389)2.91232630
40Genital tract atresia (HP:0001827)2.90043545
41Abnormality of alanine metabolism (HP:0010916)2.87885450
42Hyperalaninemia (HP:0003348)2.87885450
43Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.87885450
44Recurrent otitis media (HP:0000403)2.87240880
45Aplasia/Hypoplasia of the uvula (HP:0010293)2.82036125
46Small intestinal stenosis (HP:0012848)2.76081488
47Duodenal stenosis (HP:0100867)2.76081488
48Combined immunodeficiency (HP:0005387)2.73398151
49Abnormal spermatogenesis (HP:0008669)2.70746122
50Meckel diverticulum (HP:0002245)2.69374673
51Azoospermia (HP:0000027)2.56356455
52Increased serum pyruvate (HP:0003542)2.56352161
53Abnormality of the preputium (HP:0100587)2.53759912
54Abnormality of the duodenum (HP:0002246)2.52968035
55Slow saccadic eye movements (HP:0000514)2.51559278
56Toxemia of pregnancy (HP:0100603)2.51166189
57Abnormality of the vitamin B12 metabolism (HP:0004341)2.51165605
58Myelodysplasia (HP:0002863)2.50560138
593-Methylglutaconic aciduria (HP:0003535)2.50436262
60Aplasia/Hypoplasia of the lens (HP:0008063)2.49886504
61Abnormality of the ileum (HP:0001549)2.47710226
62Abnormal number of erythroid precursors (HP:0012131)2.44834110
63Abnormality of vitamin B metabolism (HP:0004340)2.43852989
64Impaired smooth pursuit (HP:0007772)2.42776354
65Acanthocytosis (HP:0001927)2.41638950
66Type 2 muscle fiber atrophy (HP:0003554)2.40487800
67Tubulointerstitial nephritis (HP:0001970)2.39974772
68Abnormality of the renal medulla (HP:0100957)2.38614913
69Abnormality of midbrain morphology (HP:0002418)2.38072155
70Molar tooth sign on MRI (HP:0002419)2.38072155
71Hypoplasia of the thymus (HP:0000778)2.35468234
72Hyperglycinemia (HP:0002154)2.34992613
73Abnormality of saccadic eye movements (HP:0000570)2.29335946
74Optic nerve hypoplasia (HP:0000609)2.26799448
75Thyroiditis (HP:0100646)2.26056543
76Duplicated collecting system (HP:0000081)2.21893466
77Male infertility (HP:0003251)2.21366861
78Renovascular hypertension (HP:0100817)2.20574428
79Abnormality of cells of the erythroid lineage (HP:0012130)2.17301239
80Papillary thyroid carcinoma (HP:0002895)2.11864410
81Muscle fiber atrophy (HP:0100295)2.06857471
82Abnormality of glycolysis (HP:0004366)2.06469128
83Abnormality of ocular smooth pursuit (HP:0000617)2.06133436
84Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.05477484
85Abnormality of the renal collecting system (HP:0004742)2.05450439
86Recurrent bronchitis (HP:0002837)2.04122102
87Birth length less than 3rd percentile (HP:0003561)2.03474122
88Bone marrow hypocellularity (HP:0005528)2.03048348
89Impulsivity (HP:0100710)2.02052281
90Broad foot (HP:0001769)2.01925555
91Hepatocellular necrosis (HP:0001404)2.01317418
92Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.2366768
93Dynein arm defect of respiratory motile cilia (HP:0012255)12.1945015
94Absent/shortened dynein arms (HP:0200106)12.1945015
95Aplasia/Hypoplasia of the thymus (HP:0010515)1.99040443
96Reticulocytosis (HP:0001923)1.96906430
97Short 5th finger (HP:0009237)1.94739729
98Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.93852487
99Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.92679163
100Supernumerary spleens (HP:0009799)1.91556154
101Poikilocytosis (HP:0004447)1.91283374
102Methylmalonic aciduria (HP:0012120)1.90831140
103Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.89695560
104Intestinal atresia (HP:0011100)1.88387706
105Constricted visual fields (HP:0001133)1.86177355
106Hepatic necrosis (HP:0002605)1.86151783
107Polygenic inheritance (HP:0010982)1.85637169
108True hermaphroditism (HP:0010459)1.85546704
109Cerebellar dysplasia (HP:0007033)1.85419452
110Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.84974948
111Postaxial hand polydactyly (HP:0001162)1.84432940
112Tubular atrophy (HP:0000092)1.83154267
113Abnormality of serum amino acid levels (HP:0003112)1.82338477
114Limb ataxia (HP:0002070)1.81722671
115Sloping forehead (HP:0000340)1.80598686
116Abnormality of the neuromuscular junction (HP:0003398)1.79837161
117Fatigable weakness (HP:0003473)1.79837161
118Overlapping toe (HP:0001845)1.76497813
119Horizontal nystagmus (HP:0000666)1.76259995
120Increased serum lactate (HP:0002151)1.73539658
121Decreased testicular size (HP:0008734)1.72882434
122Colon cancer (HP:0003003)1.72853221
123Abnormality of the left ventricular outflow tract (HP:0011103)1.71089568
124Subaortic stenosis (HP:0001682)1.71089568
125Abnormality of the pancreatic islet cells (HP:0006476)1.70930406
126Abnormality of endocrine pancreas physiology (HP:0012093)1.70930406
127Microcytic anemia (HP:0001935)1.70225447
128Easy fatigability (HP:0003388)1.70198459
129Flat occiput (HP:0005469)1.69260215
130Homocystinuria (HP:0002156)1.68769295
131Abnormality of homocysteine metabolism (HP:0010919)1.68769295
132Increased nuchal translucency (HP:0010880)1.68670507
133Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.66907407
134Squamous cell carcinoma (HP:0002860)1.66416934
135Agammaglobulinemia (HP:0004432)1.66259858
136Heterotopia (HP:0002282)1.65646645
137Prominent nose (HP:0000448)1.65140440
138Arteriovenous malformation (HP:0100026)1.64953281
139Abnormality of the thymus (HP:0000777)1.63273836
140Dental crowding (HP:0000678)1.62977306
141Hypoplasia of the capital femoral epiphysis (HP:0003090)1.62541943
142Retinal dysplasia (HP:0007973)1.62154088
143Abnormality of reticulocytes (HP:0004312)1.62012072
144Abnormality of cochlea (HP:0000375)1.61781127
145Increased CSF lactate (HP:0002490)1.61219588
146Weak cry (HP:0001612)1.57365400
147Postaxial foot polydactyly (HP:0001830)1.56196379
148Specific learning disability (HP:0001328)1.55602222
149Poor suck (HP:0002033)1.55137117
150Asymmetric septal hypertrophy (HP:0001670)1.55003765
151Polycystic ovaries (HP:0000147)1.53660603
152Facial cleft (HP:0002006)1.50238594
153Left ventricular hypertrophy (HP:0001712)1.49656806
154Elfin facies (HP:0004428)1.48823060
155Pancreatic cysts (HP:0001737)1.48675447
156Tubulointerstitial abnormality (HP:0001969)1.48584432
157Overriding aorta (HP:0002623)1.47724405
158Hyperacusis (HP:0010780)1.46192392
159Asthma (HP:0002099)1.45972120
160Congenital hepatic fibrosis (HP:0002612)1.45957907
161Gonadotropin excess (HP:0000837)1.45823700
162Pancreatic fibrosis (HP:0100732)1.45735472
163Astigmatism (HP:0000483)1.42763390
164Abnormality of the dental root (HP:0006486)1.40402536
165Taurodontia (HP:0000679)1.40402536
166Abnormality of permanent molar morphology (HP:0011071)1.40402536
167Nonprogressive disorder (HP:0003680)1.38852017
168Stage 5 chronic kidney disease (HP:0003774)1.38340244
169Insomnia (HP:0100785)1.36799769
170Hypodontia (HP:0000668)1.36169512
171Fasciculations (HP:0002380)1.36161797
172Type II lissencephaly (HP:0007260)1.33967242
173Aplasia/Hypoplasia of the tongue (HP:0010295)1.32602427
174Sensory axonal neuropathy (HP:0003390)1.32458875
175Retinitis pigmentosa (HP:0000510)1.31456197
176Vascular calcification (HP:0004934)1.31218780
177Abnormality of molar (HP:0011077)1.31138148
178Abnormality of molar morphology (HP:0011070)1.31138148
179Oculomotor apraxia (HP:0000657)1.30266636

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK26.54270375
2MKNK24.18796007
3MKNK13.49190485
4ZAK3.42810248
5BRD42.87726489
6ACVR1B2.83384008
7EIF2AK32.65556942
8TESK12.63668825
9ERBB32.49726399
10ICK2.14451339
11PDK310.1239258
12PDK410.1239258
13PLK41.93548013
14FRK1.88672012
15SIK21.76136061
16CDK121.69528577
17MST41.61284399
18BMPR21.54907684
19CLK11.54869771
20TSSK61.44361548
21LMTK21.42889710
22TAF11.37648192
23IRAK11.33625393
24PRKD31.33059960
25NEK21.19916171
26FLT31.14723554
27EIF2AK11.14417292
28RPS6KA51.09449956
29STK391.08071767
30SIK31.06463036
31WNK31.06304808
32BRAF1.04666685
33PLK31.03827292
34WNK41.01903803
35CDC71.01203004
36MAP3K21.00194490
37CHEK20.98078346
38RPS6KA40.97945605
39WEE10.95903803
40PTK2B0.94888830
41STK40.92201543
42TESK20.89499398
43NUAK10.86454976
44YES10.84583850
45MAPK150.79415067
46PDK10.79119065
47TEC0.78644539
48EPHA30.78237264
49IKBKB0.76439831
50PNCK0.74078249
51PLK20.73357553
52PRKCI0.73304797
53CDK90.73204822
54BRSK20.71423466
55CHUK0.71196825
56CCNB10.70942120
57DYRK1B0.70884627
58KSR10.67810778
59FER0.65546291
60ALK0.65107000
61CSNK1G10.60498111
62STK380.59119574
63TGFBR10.58849640
64DYRK30.58046171
65PASK0.55607325
66EIF2AK20.55037361
67CSNK1E0.54188659
68RIPK10.52867743
69CHEK10.49458250
70MAP3K140.48126745
71VRK20.47345680
72PLK10.47019855
73CDK80.44604133
74RAF10.44027991
75IRAK20.43341152
76CDK70.42709018
77CAMKK20.42402830
78RPS6KB20.42228809
79CDK30.41092006
80FGFR30.40838733
81TRIM280.40781270
82ATR0.38969790
83STK30.37993795
84MAP3K40.36496965
85IKBKE0.36067787
86CSNK1G30.35627976
87BUB10.34977660
88PKN10.34750156
89MAP2K60.34446656
90PKN20.34357242
91EEF2K0.34078494
92AKT30.33750251
93TTK0.32956347
94ATM0.31682051
95MAP3K60.30667345
96TYRO30.29741030
97VRK10.29647424
98MAP3K100.27955101
99MUSK0.27758646
100CDK40.27539856
101BRSK10.25587913
102CSNK2A20.24080504
103CDK60.21454654
104STK160.20024157
105EGFR0.18960460
106PIM20.18358484
107SRPK10.17774695
108CSNK2A10.17705580
109AURKA0.16285400
110PAK10.15989383
111AURKB0.15917517
112PBK0.15889535
113MARK30.15197411
114RIPK40.13947071
115MAPKAPK50.13771157
116DDR20.13339543
117PRKG20.13112678
118PINK10.12819698
119CDK20.12698693
120PRKCG0.11670718
121PDPK10.11126758
122NLK0.08999740
123NEK60.08498447
124MTOR0.08145295
125PRKG10.07821832
126NEK10.07629920
127STK38L0.07335207
128RPS6KB10.06361449
129ZAP700.06230563
130DAPK10.06102811
131MAPKAPK20.06036568
132WNK10.05815666
133PIM10.05376409
134CSNK1D0.04717563
135PRKACG0.04460171
136CDK10.04417028
137MELK0.03661654
138PRKAA10.03388064
139TLK10.03281406
140CAMK1G0.03143577
141PAK20.03024750
142GRK10.02780284
143CDK150.02684419
144GSK3B0.02547033
145GSK3A0.02218382
146MAPKAPK30.02068026
147CDK11A0.01481075
148ERN10.01477878
149RPS6KA10.01032518
150PRKDC0.00852040
151PRKACB0.00735747
152MAP3K50.00439531

Predicted pathways (KEGG)

RankGene SetZ-score
1Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005123.83863169
2Basal transcription factors_Homo sapiens_hsa030223.66242975
3Pyruvate metabolism_Homo sapiens_hsa006203.53186741
4Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.49310299
5Glycosaminoglycan degradation_Homo sapiens_hsa005313.40449350
6Vitamin B6 metabolism_Homo sapiens_hsa007503.31844287
7Selenocompound metabolism_Homo sapiens_hsa004502.98482687
8Propanoate metabolism_Homo sapiens_hsa006402.91370397
9Pentose phosphate pathway_Homo sapiens_hsa000302.75958982
10One carbon pool by folate_Homo sapiens_hsa006702.66890390
11Fanconi anemia pathway_Homo sapiens_hsa034602.49889032
12Fatty acid biosynthesis_Homo sapiens_hsa000612.41834402
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.25204500
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.23799564
15Oocyte meiosis_Homo sapiens_hsa041142.17864790
16Huntingtons disease_Homo sapiens_hsa050162.14292537
17Fatty acid elongation_Homo sapiens_hsa000622.13631007
18Primary immunodeficiency_Homo sapiens_hsa053402.02128141
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.93177353
20Systemic lupus erythematosus_Homo sapiens_hsa053221.92490640
21N-Glycan biosynthesis_Homo sapiens_hsa005101.91972956
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.88096578
23Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.87325353
24RNA transport_Homo sapiens_hsa030131.82225339
25Glucagon signaling pathway_Homo sapiens_hsa049221.79122010
26DNA replication_Homo sapiens_hsa030301.74326908
27Carbon metabolism_Homo sapiens_hsa012001.71555007
28Protein export_Homo sapiens_hsa030601.64103605
29Glycerolipid metabolism_Homo sapiens_hsa005611.61499072
30Purine metabolism_Homo sapiens_hsa002301.60966662
31Homologous recombination_Homo sapiens_hsa034401.55509476
32Linoleic acid metabolism_Homo sapiens_hsa005911.51960196
33alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.49980468
34Glutathione metabolism_Homo sapiens_hsa004801.44017550
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.41233572
36Cardiac muscle contraction_Homo sapiens_hsa042601.31340694
37Pyrimidine metabolism_Homo sapiens_hsa002401.30226225
38Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.27875223
39Biosynthesis of amino acids_Homo sapiens_hsa012301.26864907
40PPAR signaling pathway_Homo sapiens_hsa033201.23939652
41Herpes simplex infection_Homo sapiens_hsa051681.23349876
42Butanoate metabolism_Homo sapiens_hsa006501.22970140
43Carbohydrate digestion and absorption_Homo sapiens_hsa049731.22127649
44Mismatch repair_Homo sapiens_hsa034301.21019660
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.19845221
46Transcriptional misregulation in cancer_Homo sapiens_hsa052021.17575376
47Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.12679343
48Spliceosome_Homo sapiens_hsa030401.11862708
49mRNA surveillance pathway_Homo sapiens_hsa030151.11539397
50Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.10435774
51Mineral absorption_Homo sapiens_hsa049781.03995295
52Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.96867143
53Antigen processing and presentation_Homo sapiens_hsa046120.95023024
54Nitrogen metabolism_Homo sapiens_hsa009100.94545724
55Circadian rhythm_Homo sapiens_hsa047100.93514660
56Cell cycle_Homo sapiens_hsa041100.90294102
57Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.88745990
58Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.88488702
59Base excision repair_Homo sapiens_hsa034100.88074614
60Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.87701155
61Ribosome_Homo sapiens_hsa030100.87048366
62Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.86600198
63Inositol phosphate metabolism_Homo sapiens_hsa005620.86384109
64Renin-angiotensin system_Homo sapiens_hsa046140.81538017
65Chemical carcinogenesis_Homo sapiens_hsa052040.80891122
66Metabolic pathways_Homo sapiens_hsa011000.80791869
67Folate biosynthesis_Homo sapiens_hsa007900.79748684
68Fructose and mannose metabolism_Homo sapiens_hsa000510.78631662
69Proteasome_Homo sapiens_hsa030500.78466992
70Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.77748999
71RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.77066108
72Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.75313008
73Peroxisome_Homo sapiens_hsa041460.75072738
74Nucleotide excision repair_Homo sapiens_hsa034200.74276132
75Maturity onset diabetes of the young_Homo sapiens_hsa049500.73722601
76ABC transporters_Homo sapiens_hsa020100.73606094
77Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.72419959
78Dorso-ventral axis formation_Homo sapiens_hsa043200.72188453
79Glycerophospholipid metabolism_Homo sapiens_hsa005640.70812748
80Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.66414832
81Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.64374974
82Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.58488070
83Fat digestion and absorption_Homo sapiens_hsa049750.58486137
84p53 signaling pathway_Homo sapiens_hsa041150.57698989
85Bile secretion_Homo sapiens_hsa049760.56536026
86Type I diabetes mellitus_Homo sapiens_hsa049400.56039239
87Prolactin signaling pathway_Homo sapiens_hsa049170.55835261
88Legionellosis_Homo sapiens_hsa051340.55299171
89Fatty acid metabolism_Homo sapiens_hsa012120.54838587
90Ether lipid metabolism_Homo sapiens_hsa005650.54679573
91Phosphatidylinositol signaling system_Homo sapiens_hsa040700.54520641
92Fatty acid degradation_Homo sapiens_hsa000710.52541376
93Amphetamine addiction_Homo sapiens_hsa050310.52484959
94Alcoholism_Homo sapiens_hsa050340.52043956
95SNARE interactions in vesicular transport_Homo sapiens_hsa041300.49973779
96Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.48620059
97Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.48394117
98Collecting duct acid secretion_Homo sapiens_hsa049660.48340139
99Lysine degradation_Homo sapiens_hsa003100.47805073
100FoxO signaling pathway_Homo sapiens_hsa040680.47497536
101Synaptic vesicle cycle_Homo sapiens_hsa047210.47316531
102Measles_Homo sapiens_hsa051620.44406251
103Allograft rejection_Homo sapiens_hsa053300.42985619
104NF-kappa B signaling pathway_Homo sapiens_hsa040640.42613391
105Protein digestion and absorption_Homo sapiens_hsa049740.40777539
106Thyroid hormone signaling pathway_Homo sapiens_hsa049190.39665326
107Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.38669378
108Calcium signaling pathway_Homo sapiens_hsa040200.38463291
109Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.36344513
110Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.35855767
111Taste transduction_Homo sapiens_hsa047420.35215140
112RNA degradation_Homo sapiens_hsa030180.33933081
113Viral carcinogenesis_Homo sapiens_hsa052030.32136604
114Jak-STAT signaling pathway_Homo sapiens_hsa046300.31841395
115Graft-versus-host disease_Homo sapiens_hsa053320.31374496
116Steroid biosynthesis_Homo sapiens_hsa001000.30591251
117HTLV-I infection_Homo sapiens_hsa051660.30326393
118B cell receptor signaling pathway_Homo sapiens_hsa046620.29956540
119Renin secretion_Homo sapiens_hsa049240.29697923
120Thyroid hormone synthesis_Homo sapiens_hsa049180.29528098
121Sulfur relay system_Homo sapiens_hsa041220.29477659
122Colorectal cancer_Homo sapiens_hsa052100.27455618
123Central carbon metabolism in cancer_Homo sapiens_hsa052300.27437902
124Autoimmune thyroid disease_Homo sapiens_hsa053200.26417680
125Arachidonic acid metabolism_Homo sapiens_hsa005900.25921192
126Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.25819468
127Epstein-Barr virus infection_Homo sapiens_hsa051690.25695424
128Intestinal immune network for IgA production_Homo sapiens_hsa046720.25358840
129Insulin secretion_Homo sapiens_hsa049110.23315637
130Olfactory transduction_Homo sapiens_hsa047400.23138044
131Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.22018914
132TGF-beta signaling pathway_Homo sapiens_hsa043500.21894279
133Non-homologous end-joining_Homo sapiens_hsa034500.21545126
134Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.20410376
135Retinol metabolism_Homo sapiens_hsa008300.19704393
136Phenylalanine metabolism_Homo sapiens_hsa003600.19558921
137Oxidative phosphorylation_Homo sapiens_hsa001900.18441961
138Primary bile acid biosynthesis_Homo sapiens_hsa001200.18136727
139Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.16829876
140Sphingolipid metabolism_Homo sapiens_hsa006000.15890121
141Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.14394773
142Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.14361811
143RNA polymerase_Homo sapiens_hsa030200.14329603
144Regulation of autophagy_Homo sapiens_hsa041400.13087737
145Asthma_Homo sapiens_hsa053100.11176394
146Type II diabetes mellitus_Homo sapiens_hsa049300.08877816
147Leishmaniasis_Homo sapiens_hsa051400.08848122
148mTOR signaling pathway_Homo sapiens_hsa041500.08608717
149Hepatitis B_Homo sapiens_hsa051610.06027410
150Influenza A_Homo sapiens_hsa051640.05321384
151NOD-like receptor signaling pathway_Homo sapiens_hsa046210.04796310
152Adipocytokine signaling pathway_Homo sapiens_hsa049200.04428236

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