TCTN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a family of secreted and transmembrane proteins. The orthologous gene in mouse functions downstream of smoothened and rab23 to modulate hedgehog signal transduction. This protein is a component of the tectonic-like complex, which forms a barrier between the ciliary axoneme and the basal body. A mutation in this gene was found in a family with Joubert syndrome-13. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)5.79121497
2axoneme assembly (GO:0035082)5.76085268
3intraciliary transport (GO:0042073)4.73832244
4regulation of cilium movement (GO:0003352)4.14892762
5behavioral response to nicotine (GO:0035095)4.11373231
6left/right pattern formation (GO:0060972)4.10023403
7protein localization to cilium (GO:0061512)4.06127947
8regulation of nuclear cell cycle DNA replication (GO:0033262)3.95124443
9* cilium morphogenesis (GO:0060271)3.93250921
10left/right axis specification (GO:0070986)3.90592480
11nonmotile primary cilium assembly (GO:0035058)3.86135723
12cellular component assembly involved in morphogenesis (GO:0010927)3.69136823
13facial nerve structural organization (GO:0021612)3.68141601
14motile cilium assembly (GO:0044458)3.60924564
15cilium movement (GO:0003341)3.41470418
16tryptophan catabolic process (GO:0006569)3.41003207
17indole-containing compound catabolic process (GO:0042436)3.41003207
18indolalkylamine catabolic process (GO:0046218)3.41003207
19epithelial cilium movement (GO:0003351)3.34987863
20microtubule bundle formation (GO:0001578)3.33105613
21indolalkylamine metabolic process (GO:0006586)3.31669858
22ventricular system development (GO:0021591)3.24841623
23kynurenine metabolic process (GO:0070189)3.24140518
24retinal cone cell development (GO:0046549)3.21112606
25centriole assembly (GO:0098534)3.20756688
26regulation of hippo signaling (GO:0035330)3.19256899
27smoothened signaling pathway (GO:0007224)3.17819131
28limb development (GO:0060173)3.13036921
29appendage development (GO:0048736)3.13036921
30axonemal dynein complex assembly (GO:0070286)3.12723648
31detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.11285475
32mesenchymal cell differentiation involved in renal system development (GO:2001012)3.11176632
33mesenchymal cell differentiation involved in kidney development (GO:0072161)3.11176632
34negative regulation of DNA-dependent DNA replication (GO:2000104)3.10168091
35epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.07172592
36response to pheromone (GO:0019236)3.05231695
37cornea development in camera-type eye (GO:0061303)3.03413632
38fucose catabolic process (GO:0019317)3.00770521
39L-fucose metabolic process (GO:0042354)3.00770521
40L-fucose catabolic process (GO:0042355)3.00770521
41postsynaptic membrane organization (GO:0001941)2.99174694
42cranial nerve structural organization (GO:0021604)2.99011751
43nephron tubule morphogenesis (GO:0072078)2.95246417
44nephron epithelium morphogenesis (GO:0072088)2.95246417
45replicative senescence (GO:0090399)2.93573243
46regulation of collateral sprouting (GO:0048670)2.93324380
47metanephric nephron tubule development (GO:0072234)2.91686146
48metanephric tubule development (GO:0072170)2.91686146
49regulation of microtubule-based movement (GO:0060632)2.91375882
50cell projection assembly (GO:0030031)2.88265910
51piRNA metabolic process (GO:0034587)2.86190309
52detection of light stimulus involved in visual perception (GO:0050908)2.85809453
53detection of light stimulus involved in sensory perception (GO:0050962)2.85809453
54DNA methylation involved in gamete generation (GO:0043046)2.84681012
55protein polyglutamylation (GO:0018095)2.83556959
56tryptophan metabolic process (GO:0006568)2.82623811
57cellular ketone body metabolic process (GO:0046950)2.82247060
58positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.81631326
59behavioral response to ethanol (GO:0048149)2.81431650
60determination of left/right symmetry (GO:0007368)2.80228803
61regulation of B cell receptor signaling pathway (GO:0050855)2.79881995
62omega-hydroxylase P450 pathway (GO:0097267)2.77829307
63DNA synthesis involved in DNA repair (GO:0000731)2.76011422
64negative regulation of cytosolic calcium ion concentration (GO:0051481)2.75769408
65positive regulation of oligodendrocyte differentiation (GO:0048714)2.75258137
66thyroid hormone metabolic process (GO:0042403)2.72512018
67acrosome reaction (GO:0007340)2.72038227
68transmission of nerve impulse (GO:0019226)2.70774701
69metanephric epithelium development (GO:0072207)2.70133783
70reflex (GO:0060004)2.67668522
71determination of bilateral symmetry (GO:0009855)2.67519328
72gamma-aminobutyric acid transport (GO:0015812)2.65117005
73inner ear receptor stereocilium organization (GO:0060122)2.63939133
74acrosome assembly (GO:0001675)2.63510558
75cAMP catabolic process (GO:0006198)2.62913342
76microtubule-based movement (GO:0007018)2.61949639
77negative regulation of translation, ncRNA-mediated (GO:0040033)2.60635538
78regulation of translation, ncRNA-mediated (GO:0045974)2.60635538
79negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.60635538
80metanephric nephron epithelium development (GO:0072243)2.60280812
81specification of symmetry (GO:0009799)2.60192113
82mature B cell differentiation (GO:0002335)2.57450457
83male meiosis I (GO:0007141)2.56665747
84interkinetic nuclear migration (GO:0022027)2.55916592
85protein K11-linked deubiquitination (GO:0035871)2.55902929
86negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.54494570
87regulation of histone H3-K27 methylation (GO:0061085)2.54102732
88collecting duct development (GO:0072044)2.54004613
89activation of MAPKKK activity (GO:0000185)2.53319998
90benzene-containing compound metabolic process (GO:0042537)2.53314562
91photoreceptor cell maintenance (GO:0045494)2.52971056
92male meiosis (GO:0007140)2.52789337
93positive regulation of gamma-delta T cell activation (GO:0046645)2.52696409
94establishment of protein localization to Golgi (GO:0072600)2.52507750
95cell differentiation involved in metanephros development (GO:0072202)2.50998904
96generation of neurons (GO:0048699)2.50911298
97positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)2.50896389
98regulation of male gonad development (GO:2000018)2.50765446
99regulation of mitotic spindle organization (GO:0060236)2.50376179
100oxidative demethylation (GO:0070989)2.50071028
101indole-containing compound metabolic process (GO:0042430)2.49305414
102protein heterotetramerization (GO:0051290)2.48256128
103ketone body metabolic process (GO:1902224)2.47695189
104cellular biogenic amine catabolic process (GO:0042402)2.46918304
105amine catabolic process (GO:0009310)2.46918304
106androgen biosynthetic process (GO:0006702)2.42994034
107tRNA methylation (GO:0030488)2.42884439
108response to peptidoglycan (GO:0032494)2.40889789
109lateral ventricle development (GO:0021670)2.40459009
110drug catabolic process (GO:0042737)2.39994894
111synaptonemal complex assembly (GO:0007130)2.37805255
112regulation of platelet aggregation (GO:0090330)2.36679151
113retinal ganglion cell axon guidance (GO:0031290)2.36222283
114sex differentiation (GO:0007548)2.35352945
115cyclic nucleotide catabolic process (GO:0009214)2.34786608
116synapsis (GO:0007129)2.34689385
117DNA methylation (GO:0006306)2.33860375
118DNA alkylation (GO:0006305)2.33860375
119intra-S DNA damage checkpoint (GO:0031573)2.33630119
120pyrimidine nucleobase catabolic process (GO:0006208)2.32273017
121multicellular organism reproduction (GO:0032504)2.31726492
122auditory receptor cell stereocilium organization (GO:0060088)2.31383851
123nephron epithelium development (GO:0072009)2.31334356
124signal peptide processing (GO:0006465)2.30616961
125centriole replication (GO:0007099)2.30150963
126startle response (GO:0001964)2.30035231
127platelet dense granule organization (GO:0060155)2.29055969
128retinal rod cell development (GO:0046548)2.28950575
129regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.28431476
130chromosome organization involved in meiosis (GO:0070192)2.28207599
131negative regulation of sodium ion transport (GO:0010766)2.27218683
132synaptonemal complex organization (GO:0070193)2.26183973
133response to muramyl dipeptide (GO:0032495)2.25217127
134cranial nerve morphogenesis (GO:0021602)2.25096070
135negative regulation of transcription regulatory region DNA binding (GO:2000678)2.24484492
136exogenous drug catabolic process (GO:0042738)2.23645438
137regulation of action potential (GO:0098900)2.23644429
138sulfation (GO:0051923)2.23602569
139G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.23427215
140neuronal action potential (GO:0019228)2.22138756
141proline transport (GO:0015824)2.21524536
142tolerance induction (GO:0002507)2.21472067
143sperm motility (GO:0030317)2.20130248
144negative regulation of myotube differentiation (GO:0010832)2.19978901
145hematopoietic stem cell proliferation (GO:0071425)2.18911339
146nephron tubule development (GO:0072080)2.17578800
147DNA damage response, detection of DNA damage (GO:0042769)2.14259519
148positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.13747246
149interferon-gamma production (GO:0032609)2.13680881
150positive regulation of meiosis (GO:0045836)2.12808626
151female gonad development (GO:0008585)2.11282993
152eye photoreceptor cell development (GO:0042462)2.11010906
153renal tubule morphogenesis (GO:0061333)2.10867724
154DNA integration (GO:0015074)2.10162430
155pattern specification involved in kidney development (GO:0061004)2.09960052
156renal tubule development (GO:0061326)2.09672446
157photoreceptor cell development (GO:0042461)2.09641460
158positive regulation of p38MAPK cascade (GO:1900745)2.08655386
159mesonephros development (GO:0001823)2.08500023
160positive regulation of protein kinase C signaling (GO:0090037)2.07994131
161positive regulation of synaptic transmission, GABAergic (GO:0032230)2.07870746
162negative regulation of transcription by competitive promoter binding (GO:0010944)2.06590366
163histone H3-K4 methylation (GO:0051568)2.04963202
164cilium assembly (GO:0042384)2.04660440
165sympathetic nervous system development (GO:0048485)2.04545721
166amino sugar catabolic process (GO:0046348)2.04231567
167cilium organization (GO:0044782)2.03038616
168reciprocal meiotic recombination (GO:0007131)2.01947045
169reciprocal DNA recombination (GO:0035825)2.01947045
170negative regulation of granulocyte differentiation (GO:0030853)2.00822056
171presynaptic membrane assembly (GO:0097105)2.00324795
172telomere maintenance via semi-conservative replication (GO:0032201)1.99219216
173viral genome replication (GO:0019079)1.98925103
174spermatid development (GO:0007286)1.98443480
175lymphoid progenitor cell differentiation (GO:0002320)1.98260753
176negative regulation of keratinocyte proliferation (GO:0010839)1.98157669
177detection of bacterium (GO:0016045)1.97993462
178inner cell mass cell proliferation (GO:0001833)1.97686815

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.55630196
2ZNF274_21170338_ChIP-Seq_K562_Hela3.27664238
3IKZF1_21737484_ChIP-ChIP_HCT116_Human2.83891655
4VDR_22108803_ChIP-Seq_LS180_Human2.74753605
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.50612964
6CTBP2_25329375_ChIP-Seq_LNCAP_Human2.44525358
7IGF1R_20145208_ChIP-Seq_DFB_Human2.40658821
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.26206081
9TP63_19390658_ChIP-ChIP_HaCaT_Human2.22148253
10TAF15_26573619_Chip-Seq_HEK293_Human2.19113617
11CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.15091659
12CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.14292126
13PIAS1_25552417_ChIP-Seq_VCAP_Human2.09306636
14CTBP1_25329375_ChIP-Seq_LNCAP_Human2.08520018
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.07419004
16PCGF2_27294783_Chip-Seq_ESCs_Mouse2.05014448
17MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.02038701
18EWS_26573619_Chip-Seq_HEK293_Human1.92564432
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.91984654
20P300_19829295_ChIP-Seq_ESCs_Human1.91609805
21AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.91597596
22JARID2_20064375_ChIP-Seq_MESCs_Mouse1.89829209
23ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.84519684
24FUS_26573619_Chip-Seq_HEK293_Human1.84243001
25STAT3_23295773_ChIP-Seq_U87_Human1.83376702
26SMAD4_21799915_ChIP-Seq_A2780_Human1.81490324
27GBX2_23144817_ChIP-Seq_PC3_Human1.81131639
28NFE2_27457419_Chip-Seq_LIVER_Mouse1.76920804
29NR3C1_21868756_ChIP-Seq_MCF10A_Human1.76433901
30PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.75492973
31ER_23166858_ChIP-Seq_MCF-7_Human1.75491409
32EZH2_27304074_Chip-Seq_ESCs_Mouse1.74755718
33SUZ12_27294783_Chip-Seq_NPCs_Mouse1.67084748
34BMI1_23680149_ChIP-Seq_NPCS_Mouse1.63006682
35CBX2_27304074_Chip-Seq_ESCs_Mouse1.62489326
36STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.61227705
37RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.61208489
38RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.60858823
39PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.60671827
40IRF8_22096565_ChIP-ChIP_GC-B_Human1.59646772
41BCAT_22108803_ChIP-Seq_LS180_Human1.59604758
42SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.58670322
43AR_25329375_ChIP-Seq_VCAP_Human1.55773041
44TCF4_23295773_ChIP-Seq_U87_Human1.55587999
45CBP_20019798_ChIP-Seq_JUKART_Human1.54220970
46IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.54220970
47HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.54218827
48JARID2_20075857_ChIP-Seq_MESCs_Mouse1.53385673
49RNF2_27304074_Chip-Seq_ESCs_Mouse1.53062480
50MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.52794727
51PCGF2_27294783_Chip-Seq_NPCs_Mouse1.52373528
52MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.51888381
53UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.51472584
54SALL1_21062744_ChIP-ChIP_HESCs_Human1.51271821
55TOP2B_26459242_ChIP-Seq_MCF-7_Human1.50518355
56SMAD3_21741376_ChIP-Seq_EPCs_Human1.49526955
57EZH2_27294783_Chip-Seq_ESCs_Mouse1.49389597
58IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.47167959
59* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.46058292
60SCL_19346495_ChIP-Seq_HPC-7_Human1.45381366
61RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.45258937
62TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.44978561
63E2F7_22180533_ChIP-Seq_HELA_Human1.43329045
64EED_16625203_ChIP-ChIP_MESCs_Mouse1.42972882
65SMAD_19615063_ChIP-ChIP_OVARY_Human1.41942843
66RUNX2_22187159_ChIP-Seq_PCA_Human1.37271430
67SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34723635
68CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.33304077
69TCF4_22108803_ChIP-Seq_LS180_Human1.33087791
70TP53_16413492_ChIP-PET_HCT116_Human1.32375565
71MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.32314338
72P53_22387025_ChIP-Seq_ESCs_Mouse1.31605081
73RNF2_18974828_ChIP-Seq_MESCs_Mouse1.31200117
74EZH2_18974828_ChIP-Seq_MESCs_Mouse1.31200117
75BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.30365879
76ARNT_22903824_ChIP-Seq_MCF-7_Human1.30026613
77NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.29789324
78SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.28615417
79RNF2_27304074_Chip-Seq_NSC_Mouse1.28092347
80AHR_22903824_ChIP-Seq_MCF-7_Human1.27557183
81VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.27337281
82EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.26991099
83NMYC_18555785_Chip-Seq_ESCs_Mouse1.26655480
84OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26071506
85STAT6_21828071_ChIP-Seq_BEAS2B_Human1.25899752
86SMAD4_21741376_ChIP-Seq_EPCs_Human1.24964483
87NANOG_18555785_Chip-Seq_ESCs_Mouse1.24931745
88KLF5_20875108_ChIP-Seq_MESCs_Mouse1.23523859
89SUZ12_18555785_Chip-Seq_ESCs_Mouse1.22998978
90LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.22856307
91PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.21474200
92P300_18555785_Chip-Seq_ESCs_Mouse1.21314048
93E2F1_18555785_Chip-Seq_ESCs_Mouse1.20789921
94MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.19604914
95STAT3_18555785_Chip-Seq_ESCs_Mouse1.19271116
96SUZ12_27294783_Chip-Seq_ESCs_Mouse1.19154311
97EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.17999804
98EZH2_27294783_Chip-Seq_NPCs_Mouse1.17147492
99ZFX_18555785_Chip-Seq_ESCs_Mouse1.17059168
100TP53_22573176_ChIP-Seq_HFKS_Human1.16821371
101ESRRB_18555785_Chip-Seq_ESCs_Mouse1.16771257
102SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.16469210
103TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.15055619
104SOX2_18555785_Chip-Seq_ESCs_Mouse1.12023223
105FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.11888523
106SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.10959036
107CTCF_18555785_Chip-Seq_ESCs_Mouse1.10816229
108TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.10262794
109SOX2_21211035_ChIP-Seq_LN229_Gbm1.10155550
110MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.10132482
111PU1_27457419_Chip-Seq_LIVER_Mouse1.09594031
112* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09057914
113TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08950717
114FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.08834911
115OCT4_18555785_Chip-Seq_ESCs_Mouse1.08645300
116PRDM14_20953172_ChIP-Seq_ESCs_Human1.08470552
117CDX2_19796622_ChIP-Seq_MESCs_Mouse1.08347706
118IRF1_19129219_ChIP-ChIP_H3396_Human1.08318474
119FOXA1_27270436_Chip-Seq_PROSTATE_Human1.08081474
120FOXA1_25329375_ChIP-Seq_VCAP_Human1.08081474
121POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.07656340
122TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07656340
123KLF4_18555785_Chip-Seq_ESCs_Mouse1.07581195
124NANOG_19829295_ChIP-Seq_ESCs_Human1.07303620
125SOX2_19829295_ChIP-Seq_ESCs_Human1.07303620
126FLI1_21867929_ChIP-Seq_TH2_Mouse1.05424118
127CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05309019
128FOXM1_26456572_ChIP-Seq_MCF-7_Human1.04254485
129RUNX1_27457419_Chip-Seq_LIVER_Mouse1.04203227
130DROSHA_22980978_ChIP-Seq_HELA_Human1.03090500
131* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.02527922
132IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.01388723
133* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.01285839
134KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.00375128
135LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.00159759
136CDX2_22108803_ChIP-Seq_LS180_Human0.99950695
137FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.99904688
138STAT4_19710469_ChIP-ChIP_TH1__Mouse0.99738472
139AR_20517297_ChIP-Seq_VCAP_Human0.98597486
140* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.98440922
141TP53_18474530_ChIP-ChIP_U2OS_Human0.98202024
142SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.97889507
143SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.97723893
144CMYC_18555785_Chip-Seq_ESCs_Mouse0.96985478
145NOTCH1_21737748_ChIP-Seq_TLL_Human0.96347382
146PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95087554
147LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94496351
148EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.91805631
149SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.91591030
150FOXM1_23109430_ChIP-Seq_U2OS_Human0.91564085
151SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.91460402
152REST_21632747_ChIP-Seq_MESCs_Mouse0.91211138
153CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.90113790
154STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.89538553
155CRX_20693478_ChIP-Seq_RETINA_Mouse0.89441751
156ZFP57_27257070_Chip-Seq_ESCs_Mouse0.88279934
157MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.86731251
158PKCTHETA_26484144_Chip-Seq_BREAST_Human0.86258695
159AR_21572438_ChIP-Seq_LNCaP_Human0.85895316
160SPI1_23127762_ChIP-Seq_K562_Human0.85409302
161SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.84778792
162OCT4_21477851_ChIP-Seq_ESCs_Mouse0.83890444
163RING1B_27294783_Chip-Seq_NPCs_Mouse0.83674909
164POU5F1_16153702_ChIP-ChIP_HESCs_Human0.82840096

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001188_hyperpigmentation3.78030849
2MP0006292_abnormal_olfactory_placode3.53105813
3MP0003136_yellow_coat_color3.31699229
4MP0002653_abnormal_ependyma_morphology3.27447653
5MP0005174_abnormal_tail_pigmentation2.96203181
6MP0000015_abnormal_ear_pigmentation2.59567150
7MP0004043_abnormal_pH_regulation2.59089793
8MP0005409_darkened_coat_color2.49614029
9MP0004133_heterotaxia2.36366089
10MP0001984_abnormal_olfaction2.33485017
11MP0003045_fibrosis2.23799539
12MP0002102_abnormal_ear_morphology2.15754946
13MP0008875_abnormal_xenobiotic_pharmacok2.12777831
14MP0003195_calcinosis2.08646377
15MP0002249_abnormal_larynx_morphology2.05888622
16MP0006276_abnormal_autonomic_nervous2.04463015
17MP0000383_abnormal_hair_follicle1.99463583
18MP0000566_synostosis1.98277633
19MP0003880_abnormal_central_pattern1.92169120
20MP0005410_abnormal_fertilization1.87202085
21MP0001986_abnormal_taste_sensitivity1.86745649
22MP0003787_abnormal_imprinting1.80928647
23MP0008058_abnormal_DNA_repair1.78051797
24MP0004381_abnormal_hair_follicle1.76733235
25MP0001485_abnormal_pinna_reflex1.74225497
26MP0003879_abnormal_hair_cell1.71686939
27MP0005646_abnormal_pituitary_gland1.70496428
28MP0001968_abnormal_touch/_nociception1.68305937
29MP0000427_abnormal_hair_cycle1.67406395
30MP0000569_abnormal_digit_pigmentation1.66617224
31MP0009379_abnormal_foot_pigmentation1.63409211
32MP0003303_peritoneal_inflammation1.60247081
33MP0003941_abnormal_skin_development1.60004843
34MP0002095_abnormal_skin_pigmentation1.58524420
35MP0009745_abnormal_behavioral_response1.58336935
36MP0000778_abnormal_nervous_system1.52260727
37MP0001835_abnormal_antigen_presentation1.52182433
38MP0002928_abnormal_bile_duct1.52082606
39MP0003646_muscle_fatigue1.48501753
40MP0002876_abnormal_thyroid_physiology1.48374020
41MP0001501_abnormal_sleep_pattern1.48199968
42MP0002160_abnormal_reproductive_system1.40467887
43MP0002736_abnormal_nociception_after1.37060724
44MP0003698_abnormal_male_reproductive1.36854214
45MP0000049_abnormal_middle_ear1.35011609
46MP0002210_abnormal_sex_determination1.34378724
47MP0002272_abnormal_nervous_system1.32787481
48MP0002177_abnormal_outer_ear1.32584961
49MP0002572_abnormal_emotion/affect_behav1.31553577
50MP0005171_absent_coat_pigmentation1.30436177
51MP0008995_early_reproductive_senescence1.29363875
52MP0002735_abnormal_chemical_nociception1.24931796
53MP0005195_abnormal_posterior_eye1.22794395
54MP0002837_dystrophic_cardiac_calcinosis1.22430287
55MP0003111_abnormal_nucleus_morphology1.22111024
56MP0008007_abnormal_cellular_replicative1.22094815
57MP0003890_abnormal_embryonic-extraembry1.22043285
58MP0005551_abnormal_eye_electrophysiolog1.21781432
59MP0005645_abnormal_hypothalamus_physiol1.20864884
60MP0008877_abnormal_DNA_methylation1.20666315
61MP0000026_abnormal_inner_ear1.20308715
62MP0008260_abnormal_autophagy1.19951994
63MP0004145_abnormal_muscle_electrophysio1.18943828
64MP0002638_abnormal_pupillary_reflex1.18609991
65MP0001970_abnormal_pain_threshold1.17762432
66MP0001929_abnormal_gametogenesis1.17445997
67MP0003763_abnormal_thymus_physiology1.17093871
68MP0002067_abnormal_sensory_capabilities1.16546588
69MP0002277_abnormal_respiratory_mucosa1.16125861
70MP0005377_hearing/vestibular/ear_phenot1.16072711
71MP0003878_abnormal_ear_physiology1.16072711
72MP0002734_abnormal_mechanical_nocicepti1.15370497
73MP0002075_abnormal_coat/hair_pigmentati1.15343832
74MP0002064_seizures1.15101426
75MP0004885_abnormal_endolymph1.12351773
76MP0002234_abnormal_pharynx_morphology1.11759502
77MP0003786_premature_aging1.11595008
78MP0010386_abnormal_urinary_bladder1.11570888
79MP0000490_abnormal_crypts_of1.10485416
80MP0001529_abnormal_vocalization1.10180873
81MP0008872_abnormal_physiological_respon1.08208967
82MP0010678_abnormal_skin_adnexa1.08197797
83MP0005671_abnormal_response_to1.08125043
84MP0002909_abnormal_adrenal_gland1.07985024
85MP0000371_diluted_coat_color1.07822636
86MP0001270_distended_abdomen1.07680539
87MP0003937_abnormal_limbs/digits/tail_de1.07153842
88MP0002752_abnormal_somatic_nervous1.06978648
89MP0001800_abnormal_humoral_immune1.06514350
90MP0008789_abnormal_olfactory_epithelium1.05958296
91MP0005394_taste/olfaction_phenotype1.05292133
92MP0005499_abnormal_olfactory_system1.05292133
93MP0000955_abnormal_spinal_cord1.04735825
94MP0002282_abnormal_trachea_morphology1.03137436
95MP0003279_aneurysm1.02084812
96MP0001186_pigmentation_phenotype1.01411524
97MP0003011_delayed_dark_adaptation1.00726517
98MP0005075_abnormal_melanosome_morpholog1.00680986
99MP0001324_abnormal_eye_pigmentation1.00186479
100MP0002733_abnormal_thermal_nociception0.99341677
101MP0004142_abnormal_muscle_tone0.99045136
102MP0003119_abnormal_digestive_system0.98406530
103MP0005386_behavior/neurological_phenoty0.98359655
104MP0004924_abnormal_behavior0.98359655
105MP0002063_abnormal_learning/memory/cond0.97388598
106MP0005391_vision/eye_phenotype0.97367804
107MP0003635_abnormal_synaptic_transmissio0.96178330
108MP0001145_abnormal_male_reproductive0.95976530
109MP0002882_abnormal_neuron_morphology0.95736839
110MP0002184_abnormal_innervation0.95731832
111MP0005623_abnormal_meninges_morphology0.95722210
112MP0009250_abnormal_appendicular_skeleto0.94693901
113MP0005387_immune_system_phenotype0.94266953
114MP0001790_abnormal_immune_system0.94266953
115MP0003385_abnormal_body_wall0.93369267
116MP0003283_abnormal_digestive_organ0.92963061
117MP0002398_abnormal_bone_marrow0.91596791
118MP0000631_abnormal_neuroendocrine_gland0.91366826
119MP0002452_abnormal_antigen_presenting0.89643362
120MP0002229_neurodegeneration0.89581134
121MP0010094_abnormal_chromosome_stability0.88831649
122MP0002557_abnormal_social/conspecific_i0.87912538
123MP0001502_abnormal_circadian_rhythm0.86816747
124MP0004808_abnormal_hematopoietic_stem0.86205489
125MP0002938_white_spotting0.85600769
126MP0001486_abnormal_startle_reflex0.85473133
127MP0002138_abnormal_hepatobiliary_system0.85031557
128MP0002420_abnormal_adaptive_immunity0.84520955
129MP0001919_abnormal_reproductive_system0.83971914
130MP0003137_abnormal_impulse_conducting0.83594361
131MP0001819_abnormal_immune_cell0.83389026
132MP0005253_abnormal_eye_physiology0.83106500
133MP0003252_abnormal_bile_duct0.82643312
134MP0000703_abnormal_thymus_morphology0.82231984
135MP0002751_abnormal_autonomic_nervous0.82113998
136MP0001293_anophthalmia0.80767603
137MP0005257_abnormal_intraocular_pressure0.80153457
138MP0000653_abnormal_sex_gland0.80064179
139MP0004742_abnormal_vestibular_system0.79786454
140MP0002168_other_aberrant_phenotype0.79358749
141MP0002116_abnormal_craniofacial_bone0.79338386
142MP0002396_abnormal_hematopoietic_system0.78885419
143MP0003938_abnormal_ear_development0.78267380
144MP0003183_abnormal_peptide_metabolism0.77713723
145MP0000716_abnormal_immune_system0.77337516
146MP0000230_abnormal_systemic_arterial0.77255832
147MP0006072_abnormal_retinal_apoptosis0.76514227
148MP0005423_abnormal_somatic_nervous0.76337022
149MP0002723_abnormal_immune_serum0.75675219
150MP0000428_abnormal_craniofacial_morphol0.75408641
151MP0001963_abnormal_hearing_physiology0.75047183
152MP0003693_abnormal_embryo_hatching0.74922265
153MP0000538_abnormal_urinary_bladder0.74593728
154MP0000681_abnormal_thyroid_gland0.74556001
155MP0004215_abnormal_myocardial_fiber0.74171842
156MP0009046_muscle_twitch0.73376463
157MP0000465_gastrointestinal_hemorrhage0.73321471
158MP0005389_reproductive_system_phenotype0.72952984
159MP0002932_abnormal_joint_morphology0.72280165

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)4.67441278
2Absent/shortened dynein arms (HP:0200106)4.67441278
3Abnormal ciliary motility (HP:0012262)3.52172769
4Abnormal respiratory epithelium morphology (HP:0012253)3.50899571
5Abnormal respiratory motile cilium morphology (HP:0005938)3.50899571
6Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.48829105
7Chronic bronchitis (HP:0004469)3.41754822
8Gait imbalance (HP:0002141)3.25471380
9Congenital primary aphakia (HP:0007707)3.18633908
10Abnormal respiratory motile cilium physiology (HP:0012261)3.18100775
11Tubular atrophy (HP:0000092)3.16565163
12True hermaphroditism (HP:0010459)3.10716406
13Hyperventilation (HP:0002883)3.06887234
14Sex reversal (HP:0012245)2.97751034
15Abnormal sex determination (HP:0012244)2.97751034
16Genetic anticipation (HP:0003743)2.93673390
17Cystic liver disease (HP:0006706)2.92512313
18Sclerocornea (HP:0000647)2.90220726
19Chromosomal breakage induced by crosslinking agents (HP:0003221)2.88871693
20Nephronophthisis (HP:0000090)2.88742039
21Nephrogenic diabetes insipidus (HP:0009806)2.88610658
22Tubulointerstitial nephritis (HP:0001970)2.85226403
23Abnormality of the renal cortex (HP:0011035)2.84294547
24Severe visual impairment (HP:0001141)2.76050044
25Absent rod-and cone-mediated responses on ERG (HP:0007688)2.75773616
26Agammaglobulinemia (HP:0004432)2.68939660
27Molar tooth sign on MRI (HP:0002419)2.63725586
28Abnormality of midbrain morphology (HP:0002418)2.63725586
29Polydipsia (HP:0001959)2.56974443
30Abnormal drinking behavior (HP:0030082)2.56974443
31Genital tract atresia (HP:0001827)2.56790287
32Progressive cerebellar ataxia (HP:0002073)2.56258460
33Furrowed tongue (HP:0000221)2.54230436
34Chromsome breakage (HP:0040012)2.51502647
35Vaginal atresia (HP:0000148)2.48950973
36Congenital stationary night blindness (HP:0007642)2.47155217
37Rhinitis (HP:0012384)2.43999864
38Pancreatic fibrosis (HP:0100732)2.43857919
39Abnormality of the renal medulla (HP:0100957)2.41643627
40Decreased circulating renin level (HP:0003351)2.41210772
41Type II lissencephaly (HP:0007260)2.37735395
42Neoplasm of the adrenal cortex (HP:0100641)2.36519259
43Postaxial hand polydactyly (HP:0001162)2.36351704
44Poor coordination (HP:0002370)2.34906468
45Aplasia/Hypoplasia of the tibia (HP:0005772)2.34478241
46Clubbing of toes (HP:0100760)2.33690025
47Chronic mucocutaneous candidiasis (HP:0002728)2.32268702
48Recurrent cutaneous fungal infections (HP:0011370)2.32268702
49Recurrent sinusitis (HP:0011108)2.32180906
50Attenuation of retinal blood vessels (HP:0007843)2.31816638
51Meckel diverticulum (HP:0002245)2.31808716
52Stomach cancer (HP:0012126)2.30060960
53Aplasia/Hypoplasia of the uvula (HP:0010293)2.28428787
54Gaze-evoked nystagmus (HP:0000640)2.27765902
55Absent speech (HP:0001344)2.25288481
56Nasal polyposis (HP:0100582)2.24028463
57Stage 5 chronic kidney disease (HP:0003774)2.21750770
58Abnormal rod and cone electroretinograms (HP:0008323)2.20009359
59Abnormality of the ileum (HP:0001549)2.19554299
60Unilateral renal agenesis (HP:0000122)2.19471370
61Pancreatic cysts (HP:0001737)2.18675416
62Abolished electroretinogram (ERG) (HP:0000550)2.18307957
63Meningitis (HP:0001287)2.17800652
64Infertility (HP:0000789)2.16644096
65Abnormality of the carotid arteries (HP:0005344)2.14143731
66Aplasia/Hypoplasia of the tongue (HP:0010295)2.13017150
67Tubulointerstitial abnormality (HP:0001969)2.11627085
68Reticulocytopenia (HP:0001896)2.05821248
69Scanning speech (HP:0002168)2.05607769
70Abnormality of the preputium (HP:0100587)2.04913754
71Abnormal delayed hypersensitivity skin test (HP:0002963)2.02310134
72Large for gestational age (HP:0001520)2.02225636
73Anencephaly (HP:0002323)1.98390366
74Abnormality of the fingertips (HP:0001211)1.98373781
75Dyschromatopsia (HP:0007641)1.98150624
76Aplasia cutis congenita (HP:0001057)1.98001233
77Panhypogammaglobulinemia (HP:0003139)1.96535568
78Retrobulbar optic neuritis (HP:0100654)1.95977675
79Optic neuritis (HP:0100653)1.95977675
80Polyuria (HP:0000103)1.95111328
81Increased corneal curvature (HP:0100692)1.94398858
82Keratoconus (HP:0000563)1.94398858
83Ectopic kidney (HP:0000086)1.93059810
84Obstructive sleep apnea (HP:0002870)1.92697944
85Retinitis pigmentosa (HP:0000510)1.92538991
86Cerebellar dysplasia (HP:0007033)1.92510522
87Aplasia/Hypoplasia of the lens (HP:0008063)1.87869331
88Protruding tongue (HP:0010808)1.85269741
89Renal dysplasia (HP:0000110)1.85047897
90Febrile seizures (HP:0002373)1.84953534
91Lip pit (HP:0100267)1.84164119
92Median cleft lip (HP:0000161)1.83293832
93Left ventricular hypertrophy (HP:0001712)1.82800195
94Postaxial foot polydactyly (HP:0001830)1.79550866
95Preaxial hand polydactyly (HP:0001177)1.78856334
96Abnormality of chromosome stability (HP:0003220)1.77303698
97Hypothermia (HP:0002045)1.77115014
98Abnormality of DNA repair (HP:0003254)1.76883952
99Obstructive lung disease (HP:0006536)1.76171364
100Chronic obstructive pulmonary disease (HP:0006510)1.76171364
101Short foot (HP:0001773)1.76016033
102Bony spicule pigmentary retinopathy (HP:0007737)1.75068792
103Elfin facies (HP:0004428)1.74497254
104Flat cornea (HP:0007720)1.74410422
105Bowel diverticulosis (HP:0005222)1.74246883
106Inability to walk (HP:0002540)1.74064514
107Aplasia/Hypoplasia of the spleen (HP:0010451)1.73955741
108Nonprogressive disorder (HP:0003680)1.73526881
109Lissencephaly (HP:0001339)1.73384012
110Abnormality of macular pigmentation (HP:0008002)1.73033694
111Hyperacusis (HP:0010780)1.72861211
112Decreased central vision (HP:0007663)1.71953016
113Supernumerary spleens (HP:0009799)1.71691630
114Triphalangeal thumb (HP:0001199)1.71471606
115Broad-based gait (HP:0002136)1.70720980
116* Oculomotor apraxia (HP:0000657)1.70493445
117Split foot (HP:0001839)1.70218432
118Occipital encephalocele (HP:0002085)1.69963239
119Absent thumb (HP:0009777)1.69054441
120Type I transferrin isoform profile (HP:0003642)1.69009107
121Hypoplasia of the radius (HP:0002984)1.68940286
122Clumsiness (HP:0002312)1.68798086
123Broad foot (HP:0001769)1.68544674
124Optic nerve hypoplasia (HP:0000609)1.68068535
125Bronchitis (HP:0012387)1.67431969
126Male pseudohermaphroditism (HP:0000037)1.67390128
127Congenital hepatic fibrosis (HP:0002612)1.67179040
128Medial flaring of the eyebrow (HP:0010747)1.66884995
129Chorioretinal coloboma (HP:0000567)1.66088150
130Congenital sensorineural hearing impairment (HP:0008527)1.66062854
131Reduced antithrombin III activity (HP:0001976)1.65543685
132Oligodactyly (hands) (HP:0001180)1.64521176
133* Narrow forehead (HP:0000341)1.64218027
134Widely spaced teeth (HP:0000687)1.63466070
135Multicystic kidney dysplasia (HP:0000003)1.63133672
136Specific learning disability (HP:0001328)1.62951429
137Chronic sinusitis (HP:0011109)1.62262597
138Dandy-Walker malformation (HP:0001305)1.61603881
139Astigmatism (HP:0000483)1.61220023
140* Aganglionic megacolon (HP:0002251)1.60032318
141Chronic hepatic failure (HP:0100626)1.59398218
142Bronchiectasis (HP:0002110)1.59343046
143Bile duct proliferation (HP:0001408)1.58685964
144Abnormal biliary tract physiology (HP:0012439)1.58685964
145Renovascular hypertension (HP:0100817)1.58350798
146Thyroid-stimulating hormone excess (HP:0002925)1.58175896
147Abnormality of the nasal mucosa (HP:0000433)1.57979391
148Midline defect of the nose (HP:0004122)1.57520645
149Septo-optic dysplasia (HP:0100842)1.57190663
150White forelock (HP:0002211)1.57178035
151Pendular nystagmus (HP:0012043)1.57024815
152* Highly arched eyebrow (HP:0002553)1.56657839
153Cerebral aneurysm (HP:0004944)1.56450669
154Small intestinal stenosis (HP:0012848)1.56116571
155Duodenal stenosis (HP:0100867)1.56116571
156Hemiparesis (HP:0001269)1.56058078
157* Prominent nasal bridge (HP:0000426)1.55797803
158Tubulointerstitial fibrosis (HP:0005576)1.55447603
159Myositis (HP:0100614)1.54832046
160Optic nerve coloboma (HP:0000588)1.54706248
161Asplenia (HP:0001746)1.52759127
162Anophthalmia (HP:0000528)1.50328910

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK7.54974199
2ZAK4.77974425
3TLK13.94071337
4MKNK23.80978840
5CASK3.70386193
6TNIK3.22563634
7IRAK33.20576217
8TNK22.97931766
9BMPR1B2.94474704
10PRKD22.66600900
11WNK32.63701801
12ACVR1B2.45048376
13STK382.36243536
14IRAK42.24288387
15MAP4K22.20959595
16BLK2.18057145
17MAP3K42.11887334
18SRPK12.07813681
19IRAK12.06014742
20PRPF4B1.98644781
21NLK1.92224484
22PNCK1.78940546
23MKNK11.77994619
24WNK41.75712601
25IRAK21.75600193
26PTK2B1.71298051
27FES1.70012475
28TEC1.64905346
29CLK11.63621999
30OXSR11.59158024
31YES11.57935606
32TXK1.55002959
33STK391.54288626
34MAPK131.45244343
35NTRK31.40811173
36BCR1.36003399
37MARK11.35189136
38ADRBK11.30072325
39BRD41.25227976
40BTK1.24639724
41TTK1.24631455
42EPHA41.23574505
43MAPK151.23556036
44CDK91.23092815
45PRKD31.22445398
46STK38L1.22139963
47NUAK11.21611289
48PRKCH1.19318124
49CDK31.18809684
50EIF2AK21.13806774
51BCKDK1.12009953
52TAOK21.10500383
53MAP2K71.06973413
54MAP4K11.05395785
55MATK1.04710864
56EIF2AK31.04468836
57PAK31.03660000
58HIPK20.99392872
59CAMK10.98537093
60SIK20.96965929
61TGFBR10.96711830
62CDK190.96280178
63PRKCE0.94967945
64DYRK1B0.94317864
65PIM20.93007671
66CSK0.88635110
67PRKCG0.88492507
68CAMKK20.87768036
69MAPKAPK50.86610333
70NME20.86284778
71ATR0.85925400
72KIT0.85255554
73ERBB30.84535863
74MUSK0.81892798
75GRK10.81791654
76MAPKAPK30.80364971
77DAPK20.76602811
78TAOK30.76007456
79STK110.74043119
80STK160.72961818
81PLK20.72950295
82MAP3K140.72868118
83HCK0.72796064
84PIK3CA0.72404586
85ERBB20.72273546
86CSNK1A1L0.71527665
87CSNK1G20.71432435
88WNK10.71337901
89PIM10.70695498
90NTRK20.67959438
91NEK60.67764889
92FGFR20.67357858
93EPHA30.66956367
94CAMK1G0.65144306
95PKN10.64949065
96SGK20.64826924
97BRSK20.64825537
98FER0.64468093
99VRK10.63774808
100INSRR0.62138170
101CAMK2A0.61700500
102IKBKE0.61226487
103NEK20.60869818
104LYN0.60066590
105ZAP700.59915612
106DYRK20.59318854
107CSNK1G10.59010725
108IKBKB0.58773943
109PRKAA20.58572366
110CDK120.57066143
111CSNK1G30.54346318
112RIPK40.54124794
113CAMKK10.53005450
114CHUK0.52895738
115PRKAA10.52876458
116TRIM280.50840166
117DYRK1A0.50839308
118ADRBK20.50203002
119UHMK10.49128797
120CAMK40.48720717
121MST40.48679010
122AKT30.48609597
123BMPR20.48584395
124BRAF0.47548372
125LATS10.47479076
126STK30.47433555
127MET0.47124887
128ABL10.46820918
129PLK10.46371354
130MAP3K70.45982854
131CHEK20.45112976
132PRKACA0.45082461
133PRKCZ0.44572448
134CAMK1D0.42535059
135PLK40.42248912
136WEE10.41211910
137PHKG20.40432391
138PHKG10.40432391
139CSNK1A10.39051820
140NME10.37610456
141SGK2230.37584386
142SGK4940.37584386
143MAP2K40.37246771
144SYK0.37099346
145PRKCI0.37012081
146CDC42BPA0.36459388
147AKT10.36151805
148DDR20.32616810
149JAK10.32389543
150MAP3K100.32253519
151NEK90.32235827
152ALK0.32127249
153PRKG10.30418298
154OBSCN0.30208789
155CSNK1D0.30118447
156MARK20.29684552
157SGK30.29204912
158PINK10.27998973
159CSF1R0.27904711
160ATM0.27855937
161DYRK30.27693889
162PRKD10.27246702
163GSK3B0.26782428
164RPS6KA50.26644289
165CDK70.25941873
166LCK0.25760265

Predicted pathways (KEGG)

RankGene SetZ-score
1Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.72160125
2Butanoate metabolism_Homo sapiens_hsa006502.55113876
3Linoleic acid metabolism_Homo sapiens_hsa005912.45067755
4Fanconi anemia pathway_Homo sapiens_hsa034602.41494057
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.26010725
6Phototransduction_Homo sapiens_hsa047442.11176490
7Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.10243158
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.08452943
9ABC transporters_Homo sapiens_hsa020101.99328393
10Homologous recombination_Homo sapiens_hsa034401.95977104
11Nitrogen metabolism_Homo sapiens_hsa009101.94561987
12Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.94253571
13Primary bile acid biosynthesis_Homo sapiens_hsa001201.88768440
14Tryptophan metabolism_Homo sapiens_hsa003801.88535661
15Primary immunodeficiency_Homo sapiens_hsa053401.81855382
16Chemical carcinogenesis_Homo sapiens_hsa052041.80849593
17Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.80836038
18Histidine metabolism_Homo sapiens_hsa003401.71404469
19DNA replication_Homo sapiens_hsa030301.65808506
20Ether lipid metabolism_Homo sapiens_hsa005651.64442240
21Maturity onset diabetes of the young_Homo sapiens_hsa049501.63148614
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.62801110
23Basal cell carcinoma_Homo sapiens_hsa052171.61324290
24Propanoate metabolism_Homo sapiens_hsa006401.58478485
25Steroid hormone biosynthesis_Homo sapiens_hsa001401.57630658
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.56664956
27beta-Alanine metabolism_Homo sapiens_hsa004101.53627113
28Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.48290564
29Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.44432852
30NF-kappa B signaling pathway_Homo sapiens_hsa040641.43720888
31Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.42901532
32Retinol metabolism_Homo sapiens_hsa008301.36527706
33Olfactory transduction_Homo sapiens_hsa047401.36514919
34Base excision repair_Homo sapiens_hsa034101.35378680
35Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.32821522
36Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.31560372
37Other glycan degradation_Homo sapiens_hsa005111.29885845
38Caffeine metabolism_Homo sapiens_hsa002321.28864912
39Ribosome_Homo sapiens_hsa030101.28753663
40B cell receptor signaling pathway_Homo sapiens_hsa046621.28093256
41Peroxisome_Homo sapiens_hsa041461.27731531
42Salivary secretion_Homo sapiens_hsa049701.26234500
43Basal transcription factors_Homo sapiens_hsa030221.23108774
44Huntingtons disease_Homo sapiens_hsa050161.18758133
45Morphine addiction_Homo sapiens_hsa050321.18334015
46Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.14393869
47Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.14054978
48GABAergic synapse_Homo sapiens_hsa047271.14041993
49Wnt signaling pathway_Homo sapiens_hsa043101.13387833
50p53 signaling pathway_Homo sapiens_hsa041151.12910659
51Transcriptional misregulation in cancer_Homo sapiens_hsa052021.10236392
52Selenocompound metabolism_Homo sapiens_hsa004501.09339911
53Protein export_Homo sapiens_hsa030601.08681974
54Taste transduction_Homo sapiens_hsa047421.07779591
55Ovarian steroidogenesis_Homo sapiens_hsa049131.06567506
56Notch signaling pathway_Homo sapiens_hsa043301.05169213
57Measles_Homo sapiens_hsa051621.05088109
58Spliceosome_Homo sapiens_hsa030401.04597773
59Melanogenesis_Homo sapiens_hsa049160.99306824
60Intestinal immune network for IgA production_Homo sapiens_hsa046720.97490069
61mRNA surveillance pathway_Homo sapiens_hsa030150.97427473
62Jak-STAT signaling pathway_Homo sapiens_hsa046300.96699574
63Nucleotide excision repair_Homo sapiens_hsa034200.96381523
64Hedgehog signaling pathway_Homo sapiens_hsa043400.96050572
65Hematopoietic cell lineage_Homo sapiens_hsa046400.94831399
66Glycerolipid metabolism_Homo sapiens_hsa005610.93326566
67Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.92966208
68Herpes simplex infection_Homo sapiens_hsa051680.92960659
69Regulation of autophagy_Homo sapiens_hsa041400.92876643
70Phosphatidylinositol signaling system_Homo sapiens_hsa040700.90221127
71Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.89349644
72Cocaine addiction_Homo sapiens_hsa050300.89227145
73Acute myeloid leukemia_Homo sapiens_hsa052210.89051763
74Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.86764764
75Nicotine addiction_Homo sapiens_hsa050330.84376460
76Alcoholism_Homo sapiens_hsa050340.83836090
77HTLV-I infection_Homo sapiens_hsa051660.82157576
78Purine metabolism_Homo sapiens_hsa002300.81096732
79Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.80916533
80Mismatch repair_Homo sapiens_hsa034300.80145848
81RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.78999755
82Aldosterone synthesis and secretion_Homo sapiens_hsa049250.77952646
83Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.77646867
84Cell cycle_Homo sapiens_hsa041100.75992631
85Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.75750471
86Circadian entrainment_Homo sapiens_hsa047130.73772628
87Sphingolipid metabolism_Homo sapiens_hsa006000.73609534
88Insulin secretion_Homo sapiens_hsa049110.71925643
89Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.71880561
90Sulfur relay system_Homo sapiens_hsa041220.70707916
91Osteoclast differentiation_Homo sapiens_hsa043800.69746218
92Steroid biosynthesis_Homo sapiens_hsa001000.69580808
93Non-homologous end-joining_Homo sapiens_hsa034500.69285881
94Glycosaminoglycan degradation_Homo sapiens_hsa005310.69167383
95Axon guidance_Homo sapiens_hsa043600.69051664
96Endometrial cancer_Homo sapiens_hsa052130.68890417
97Dopaminergic synapse_Homo sapiens_hsa047280.68270901
98Toll-like receptor signaling pathway_Homo sapiens_hsa046200.68269133
99Chemokine signaling pathway_Homo sapiens_hsa040620.67364895
100Inositol phosphate metabolism_Homo sapiens_hsa005620.67357296
101Lysine degradation_Homo sapiens_hsa003100.66311734
102Arachidonic acid metabolism_Homo sapiens_hsa005900.65568173
103T cell receptor signaling pathway_Homo sapiens_hsa046600.65560784
104Leishmaniasis_Homo sapiens_hsa051400.65535903
105RNA polymerase_Homo sapiens_hsa030200.65116207
106Fatty acid degradation_Homo sapiens_hsa000710.65010470
107SNARE interactions in vesicular transport_Homo sapiens_hsa041300.64978294
108Oxidative phosphorylation_Homo sapiens_hsa001900.64772461
109Dorso-ventral axis formation_Homo sapiens_hsa043200.64392532
110Pyrimidine metabolism_Homo sapiens_hsa002400.64242742
111Tyrosine metabolism_Homo sapiens_hsa003500.62927413
112Pathways in cancer_Homo sapiens_hsa052000.62848227
113Cholinergic synapse_Homo sapiens_hsa047250.61651826
114Calcium signaling pathway_Homo sapiens_hsa040200.61567565
115Prostate cancer_Homo sapiens_hsa052150.61061749
116Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.60882801
117Systemic lupus erythematosus_Homo sapiens_hsa053220.59974263
118Glutamatergic synapse_Homo sapiens_hsa047240.59503558
119Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.59286695
120Chronic myeloid leukemia_Homo sapiens_hsa052200.58390972
121Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.58345756
122Thyroid cancer_Homo sapiens_hsa052160.58062012
123Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.57746429
124Graft-versus-host disease_Homo sapiens_hsa053320.57639881
125Vascular smooth muscle contraction_Homo sapiens_hsa042700.57244477
126Apoptosis_Homo sapiens_hsa042100.57146620
127N-Glycan biosynthesis_Homo sapiens_hsa005100.56821351
128Metabolic pathways_Homo sapiens_hsa011000.56327619
129Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56287731
130Small cell lung cancer_Homo sapiens_hsa052220.55903054
131Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.55127407
132Cardiac muscle contraction_Homo sapiens_hsa042600.54110340
133cAMP signaling pathway_Homo sapiens_hsa040240.53810551
134Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.53697277
135Gastric acid secretion_Homo sapiens_hsa049710.52492760
136Epstein-Barr virus infection_Homo sapiens_hsa051690.52471791
137Hepatitis B_Homo sapiens_hsa051610.52211993
138Influenza A_Homo sapiens_hsa051640.51611089
139Amphetamine addiction_Homo sapiens_hsa050310.51212649
140Ras signaling pathway_Homo sapiens_hsa040140.51034576
141NOD-like receptor signaling pathway_Homo sapiens_hsa046210.51021648
142Oxytocin signaling pathway_Homo sapiens_hsa049210.50822543
143Long-term depression_Homo sapiens_hsa047300.50821483
144Circadian rhythm_Homo sapiens_hsa047100.50817849
145Antigen processing and presentation_Homo sapiens_hsa046120.50055222
146Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.49800686
147Viral carcinogenesis_Homo sapiens_hsa052030.49059962
148Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.48545119
149Pentose and glucuronate interconversions_Homo sapiens_hsa000400.48316692
150AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.48222246
151Fatty acid biosynthesis_Homo sapiens_hsa000610.48131935
152Tuberculosis_Homo sapiens_hsa051520.48079608
153Hippo signaling pathway_Homo sapiens_hsa043900.47127528
154Serotonergic synapse_Homo sapiens_hsa047260.46339390
155Cyanoamino acid metabolism_Homo sapiens_hsa004600.45744773
156Glycerophospholipid metabolism_Homo sapiens_hsa005640.41060681
157Glutathione metabolism_Homo sapiens_hsa004800.40461317
158Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.40334563
159Collecting duct acid secretion_Homo sapiens_hsa049660.38711014
160Parkinsons disease_Homo sapiens_hsa050120.38637432
161RNA degradation_Homo sapiens_hsa030180.36298338
162Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.35392503
163Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.34352436
164Phenylalanine metabolism_Homo sapiens_hsa003600.32376333
165TGF-beta signaling pathway_Homo sapiens_hsa043500.31002195

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