TDG

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.38368180
2DNA strand elongation involved in DNA replication (GO:0006271)4.40041765
3negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.22837763
4DNA strand elongation (GO:0022616)4.16175673
5viral transcription (GO:0019083)4.16161381
6mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.14396896
7negative regulation of RNA splicing (GO:0033119)4.12031698
8translational termination (GO:0006415)4.05254801
9ribosomal small subunit assembly (GO:0000028)4.02455596
10DNA replication initiation (GO:0006270)3.95976276
11telomere maintenance via semi-conservative replication (GO:0032201)3.92135759
12histone exchange (GO:0043486)3.85651635
13maturation of SSU-rRNA (GO:0030490)3.84713015
14establishment of protein localization to mitochondrial membrane (GO:0090151)3.84206574
15peptidyl-arginine omega-N-methylation (GO:0035247)3.75859703
16spliceosomal snRNP assembly (GO:0000387)3.72146142
17protein localization to kinetochore (GO:0034501)3.67179437
18purine nucleobase biosynthetic process (GO:0009113)3.63777545
19proteasome assembly (GO:0043248)3.62521397
20nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.62504488
21translational elongation (GO:0006414)3.59249463
22negative regulation of mRNA processing (GO:0050686)3.57273628
23chaperone-mediated protein transport (GO:0072321)3.56815218
24viral mRNA export from host cell nucleus (GO:0046784)3.50246018
25spliceosomal complex assembly (GO:0000245)3.48444456
26translational initiation (GO:0006413)3.48379444
27DNA damage response, detection of DNA damage (GO:0042769)3.47788135
28exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.45714720
29ATP synthesis coupled proton transport (GO:0015986)3.43577422
30energy coupled proton transport, down electrochemical gradient (GO:0015985)3.43577422
31SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.42568546
32mRNA splicing, via spliceosome (GO:0000398)3.41090019
33RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.41090019
34regulation of helicase activity (GO:0051095)3.40260544
35negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.40108437
36nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.38378763
37mitotic recombination (GO:0006312)3.38244363
38ribosomal small subunit biogenesis (GO:0042274)3.38122630
39RNA splicing, via transesterification reactions (GO:0000375)3.37794361
40establishment of integrated proviral latency (GO:0075713)3.35507564
41negative regulation of DNA-dependent DNA replication (GO:2000104)3.34895240
42telomere maintenance via recombination (GO:0000722)3.34817433
43formation of translation preinitiation complex (GO:0001731)3.34813216
44DNA double-strand break processing (GO:0000729)3.34608818
45cotranslational protein targeting to membrane (GO:0006613)3.33998645
46regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.33274312
47regulation of mitotic spindle checkpoint (GO:1903504)3.33274312
48protein targeting to ER (GO:0045047)3.32118103
49termination of RNA polymerase II transcription (GO:0006369)3.32024433
50mitotic nuclear envelope disassembly (GO:0007077)3.31971043
51establishment of viral latency (GO:0019043)3.30940195
52folic acid-containing compound biosynthetic process (GO:0009396)3.28431921
53DNA duplex unwinding (GO:0032508)3.27782613
54regulation of centriole replication (GO:0046599)3.25685599
55cellular protein complex disassembly (GO:0043624)3.25647784
56ribosome assembly (GO:0042255)3.25252074
57DNA geometric change (GO:0032392)3.24087684
58DNA topological change (GO:0006265)3.23687084
59regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.23423991
60nuclear pore organization (GO:0006999)3.23149350
61peptidyl-arginine N-methylation (GO:0035246)3.22586175
62peptidyl-arginine methylation (GO:0018216)3.22586175
63protein complex disassembly (GO:0043241)3.22363406
64viral life cycle (GO:0019058)3.22271030
65metaphase plate congression (GO:0051310)3.21126112
66nucleosome disassembly (GO:0006337)3.20779221
67protein-DNA complex disassembly (GO:0032986)3.20779221
68DNA ligation (GO:0006266)3.19564713
69IMP biosynthetic process (GO:0006188)3.18399759
70nucleotide-excision repair, DNA gap filling (GO:0006297)3.17673148
71rRNA processing (GO:0006364)3.16266062
72pseudouridine synthesis (GO:0001522)3.15985085
73DNA replication checkpoint (GO:0000076)3.15265780
74ribosomal large subunit biogenesis (GO:0042273)3.14342532
75establishment of protein localization to endoplasmic reticulum (GO:0072599)3.14068939
76DNA replication-dependent nucleosome assembly (GO:0006335)3.13522590
77DNA replication-dependent nucleosome organization (GO:0034723)3.13522590
78negative regulation of ligase activity (GO:0051352)3.11346202
79negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.11346202
80protein localization to chromosome, centromeric region (GO:0071459)3.11174987
81kinetochore organization (GO:0051383)3.08720494
82anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.08053120
83negative regulation of mRNA metabolic process (GO:1903312)3.07911955
84mitotic sister chromatid cohesion (GO:0007064)3.07791619
85mitochondrial RNA metabolic process (GO:0000959)3.06886256
86nuclear envelope disassembly (GO:0051081)3.06592658
87membrane disassembly (GO:0030397)3.06592658
88telomere maintenance via telomere lengthening (GO:0010833)3.06528449
89protein localization to endoplasmic reticulum (GO:0070972)3.06487948
90positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.05453703
91non-recombinational repair (GO:0000726)3.05233793
92double-strand break repair via nonhomologous end joining (GO:0006303)3.05233793
93rRNA metabolic process (GO:0016072)3.04398756
94DNA deamination (GO:0045006)3.03723395
95macromolecular complex disassembly (GO:0032984)3.03636646
96spliceosomal tri-snRNP complex assembly (GO:0000244)3.00573530
97protein neddylation (GO:0045116)3.00222702
98histone arginine methylation (GO:0034969)2.99741781
99regulation of mitochondrial translation (GO:0070129)2.98784615
100nuclear-transcribed mRNA catabolic process (GO:0000956)2.98013735
101spindle assembly checkpoint (GO:0071173)2.97685026
102cullin deneddylation (GO:0010388)2.97132290
103nuclear pore complex assembly (GO:0051292)2.96979000
104mitotic spindle assembly checkpoint (GO:0007094)2.96183004
105negative regulation of mitotic sister chromatid segregation (GO:0033048)2.95624311
106negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.95624311
107negative regulation of sister chromatid segregation (GO:0033046)2.95624311
108negative regulation of mitotic sister chromatid separation (GO:2000816)2.95624311
109dosage compensation (GO:0007549)2.95322175
110rRNA modification (GO:0000154)2.95079215
111negative regulation of chromosome segregation (GO:0051985)2.94083611
112CENP-A containing nucleosome assembly (GO:0034080)2.93994774
113histone H2A acetylation (GO:0043968)2.93959690
114translesion synthesis (GO:0019985)2.92706928
115replication fork processing (GO:0031297)2.92542281
116regulation of double-strand break repair via homologous recombination (GO:0010569)2.91052016
117chromatin remodeling at centromere (GO:0031055)2.90565533
118DNA catabolic process, exonucleolytic (GO:0000738)2.90366924
119sister chromatid segregation (GO:0000819)2.89891900
120regulation of mitotic metaphase/anaphase transition (GO:0030071)2.89838500
121regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.89838500
122somatic diversification of immune receptors via somatic mutation (GO:0002566)2.89667254
123somatic hypermutation of immunoglobulin genes (GO:0016446)2.89667254
124termination of RNA polymerase III transcription (GO:0006386)2.89323550
125transcription elongation from RNA polymerase III promoter (GO:0006385)2.89323550
126translation (GO:0006412)2.88744051
127mitotic metaphase plate congression (GO:0007080)2.87477170
128ribonucleoprotein complex biogenesis (GO:0022613)2.87031605
129mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.86970786
130NADH dehydrogenase complex assembly (GO:0010257)2.86970786
131DNA replication-independent nucleosome organization (GO:0034724)2.86959802
132DNA replication-independent nucleosome assembly (GO:0006336)2.86959802
133ATP-dependent chromatin remodeling (GO:0043044)2.86610725
134negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.84118659
135regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.82680658
136mRNA catabolic process (GO:0006402)2.81049156
137RNA catabolic process (GO:0006401)2.79761025
138histone mRNA metabolic process (GO:0008334)2.79536452
139nucleobase biosynthetic process (GO:0046112)2.79071244
140postreplication repair (GO:0006301)2.78213320
141mitotic spindle checkpoint (GO:0071174)2.77226635
142kinetochore assembly (GO:0051382)2.76224337
143spindle checkpoint (GO:0031577)2.75126406
144RNA export from nucleus (GO:0006405)2.69638065
145mitotic sister chromatid segregation (GO:0000070)2.67889922
1463-UTR-mediated mRNA stabilization (GO:0070935)2.67730112
147RNA splicing (GO:0008380)2.66410002
148IMP metabolic process (GO:0046040)2.66398526
149alternative mRNA splicing, via spliceosome (GO:0000380)2.64982752
150intra-S DNA damage checkpoint (GO:0031573)2.64493241

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.31961126
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.72954499
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.35683975
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.85622844
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.80155134
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.39276695
7MYC_19079543_ChIP-ChIP_MESCs_Mouse3.12360135
8MYC_19030024_ChIP-ChIP_MESCs_Mouse2.75862418
9XRN2_22483619_ChIP-Seq_HELA_Human2.68693172
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.67797460
11MYC_18358816_ChIP-ChIP_MESCs_Mouse2.66452332
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.55082655
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.48281012
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.46455997
15MYC_22102868_ChIP-Seq_BL_Human2.40339035
16* ETS1_20019798_ChIP-Seq_JURKAT_Human2.36393990
17GABP_17652178_ChIP-ChIP_JURKAT_Human2.34909035
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.34583728
19TP63_19390658_ChIP-ChIP_HaCaT_Human2.29405514
20NELFA_20434984_ChIP-Seq_ESCs_Mouse2.24527981
21CREB1_15753290_ChIP-ChIP_HEK293T_Human2.24303507
22CIITA_25753668_ChIP-Seq_RAJI_Human2.17533669
23JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.14482934
24MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.14233626
25SALL1_21062744_ChIP-ChIP_HESCs_Human2.10987026
26TTF2_22483619_ChIP-Seq_HELA_Human2.04726640
27MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.98833490
28E2F1_21310950_ChIP-Seq_MCF-7_Human1.97811142
29CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.91707521
30DCP1A_22483619_ChIP-Seq_HELA_Human1.89001320
31FOXP3_21729870_ChIP-Seq_TREG_Human1.87855004
32VDR_23849224_ChIP-Seq_CD4+_Human1.87208322
33RBPJ_22232070_ChIP-Seq_NCS_Mouse1.86795478
34CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.85120025
35HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.83743721
36SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.80196124
37MYCN_18555785_ChIP-Seq_MESCs_Mouse1.79510760
38TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.78075236
39THAP11_20581084_ChIP-Seq_MESCs_Mouse1.75787790
40* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.75507439
41E2F1_18555785_ChIP-Seq_MESCs_Mouse1.74167270
42EWS_26573619_Chip-Seq_HEK293_Human1.72204853
43GABP_19822575_ChIP-Seq_HepG2_Human1.71727780
44AR_21909140_ChIP-Seq_LNCAP_Human1.71272196
45YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.68259685
46ZFX_18555785_ChIP-Seq_MESCs_Mouse1.66601924
47POU5F1_16153702_ChIP-ChIP_HESCs_Human1.63686017
48NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.62507217
49ELK1_19687146_ChIP-ChIP_HELA_Human1.59426299
50PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55620466
51ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.55619528
52POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.54859801
53FUS_26573619_Chip-Seq_HEK293_Human1.53108508
54KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.53004161
55PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.51776517
56* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.49883009
57VDR_21846776_ChIP-Seq_THP-1_Human1.49761317
58HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.44208908
59SRF_21415370_ChIP-Seq_HL-1_Mouse1.44096426
60NANOG_18555785_ChIP-Seq_MESCs_Mouse1.41971802
61KDM5A_27292631_Chip-Seq_BREAST_Human1.40974754
62ZNF274_21170338_ChIP-Seq_K562_Hela1.39564437
63HOXB4_20404135_ChIP-ChIP_EML_Mouse1.36976332
64ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.34577721
65ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.34308250
66SOX2_18555785_ChIP-Seq_MESCs_Mouse1.34282925
67FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.33950401
68YY1_21170310_ChIP-Seq_MESCs_Mouse1.33264666
69CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.29441426
70CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.26611228
71* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.24953562
72ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.22029856
73* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.21372707
74* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.16021647
75IGF1R_20145208_ChIP-Seq_DFB_Human1.15112605
76POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.14758476
77MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.14111422
78ERG_20887958_ChIP-Seq_HPC-7_Mouse1.13876427
79SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.08147192
80MYC_18940864_ChIP-ChIP_HL60_Human1.07326713
81KLF4_18555785_ChIP-Seq_MESCs_Mouse1.06917919
82VDR_22108803_ChIP-Seq_LS180_Human1.05756961
83PADI4_21655091_ChIP-ChIP_MCF-7_Human1.04319062
84SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.03474163
85* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.02379529
86* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.02157612
87CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.00902102
88FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.98570994
89PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.96970359
90TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96086125
91IRF1_19129219_ChIP-ChIP_H3396_Human0.96043474
92NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.95730267
93NANOG_21062744_ChIP-ChIP_HESCs_Human0.95517333
94* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.94718772
95SOX2_16153702_ChIP-ChIP_HESCs_Human0.93218603
96DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.91220415
97KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.90522859
98POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.88770549
99SOX17_20123909_ChIP-Seq_XEN_Mouse0.88229379
100HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.87684620
101NOTCH1_21737748_ChIP-Seq_TLL_Human0.87564582
102* TFEB_21752829_ChIP-Seq_HELA_Human0.84833979
103CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.84088738
104TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.84038492
105UTX_26944678_Chip-Seq_JUKART_Human0.82675275
106OCT4_18692474_ChIP-Seq_MEFs_Mouse0.82418130
107ELK1_22589737_ChIP-Seq_MCF10A_Human0.81899042
108BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.81651672
109POU3F2_20337985_ChIP-ChIP_501MEL_Human0.80664285
110* TAF15_26573619_Chip-Seq_HEK293_Human0.79864987
111CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.78759003
112NANOG_16153702_ChIP-ChIP_HESCs_Human0.78452741
113SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.78393310
114ZFP281_18757296_ChIP-ChIP_E14_Mouse0.77461222
115* TCF3_18692474_ChIP-Seq_MEFs_Mouse0.77014184
116E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.76810858
117* SPI1_23547873_ChIP-Seq_NB4_Human0.76423496
118TCF7_22412390_ChIP-Seq_EML_Mouse0.76187012
119SRY_22984422_ChIP-ChIP_TESTIS_Rat0.75808496
120CHD1_26751641_Chip-Seq_LNCaP_Human0.75374661
121NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.71850727
122HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.70094159
123GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.69315017
124FLI1_27457419_Chip-Seq_LIVER_Mouse0.69058982
125KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.67308827
126KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.67308827
127KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.67308827

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.52028147
2MP0010094_abnormal_chromosome_stability3.51521474
3MP0010030_abnormal_orbit_morphology3.47295841
4MP0003111_abnormal_nucleus_morphology3.46517827
5MP0004957_abnormal_blastocyst_morpholog3.21938365
6MP0003077_abnormal_cell_cycle3.20568444
7MP0000537_abnormal_urethra_morphology2.72136082
8MP0008932_abnormal_embryonic_tissue2.52767921
9MP0008007_abnormal_cellular_replicative2.41929844
10MP0008877_abnormal_DNA_methylation2.36291986
11MP0001529_abnormal_vocalization2.32130307
12MP0000566_synostosis2.31625139
13MP0008058_abnormal_DNA_repair2.29443179
14MP0008057_abnormal_DNA_replication2.22714375
15MP0000350_abnormal_cell_proliferation1.98721866
16MP0003123_paternal_imprinting1.96539183
17MP0001730_embryonic_growth_arrest1.95512737
18MP0008995_early_reproductive_senescence1.95341481
19MP0003718_maternal_effect1.94025833
20MP0009697_abnormal_copulation1.87621811
21MP0000049_abnormal_middle_ear1.82263205
22MP0001293_anophthalmia1.75773611
23MP0009053_abnormal_anal_canal1.74959176
24MP0003890_abnormal_embryonic-extraembry1.73816684
25MP0002084_abnormal_developmental_patter1.73413057
26MP0002085_abnormal_embryonic_tissue1.72461620
27MP0001697_abnormal_embryo_size1.67622006
28MP0006292_abnormal_olfactory_placode1.67069879
29MP0002102_abnormal_ear_morphology1.64801169
30MP0003119_abnormal_digestive_system1.61636326
31MP0000490_abnormal_crypts_of1.60248719
32MP0003121_genomic_imprinting1.57967786
33MP0002938_white_spotting1.57097340
34MP0002396_abnormal_hematopoietic_system1.56825447
35MP0006054_spinal_hemorrhage1.56510684
36MP0005380_embryogenesis_phenotype1.56133907
37MP0001672_abnormal_embryogenesis/_devel1.56133907
38MP0001188_hyperpigmentation1.53637668
39MP0010352_gastrointestinal_tract_polyps1.50832196
40MP0002653_abnormal_ependyma_morphology1.50762644
41MP0004197_abnormal_fetal_growth/weight/1.48716621
42MP0008789_abnormal_olfactory_epithelium1.48204023
43MP0002080_prenatal_lethality1.43268658
44MP0004808_abnormal_hematopoietic_stem1.42688178
45MP0006072_abnormal_retinal_apoptosis1.42537825
46MP0003984_embryonic_growth_retardation1.42357639
47MP0002088_abnormal_embryonic_growth/wei1.41784065
48MP0005076_abnormal_cell_differentiation1.41517780
49MP0002751_abnormal_autonomic_nervous1.41299158
50MP0000428_abnormal_craniofacial_morphol1.40375925
51MP0003315_abnormal_perineum_morphology1.38865236
52MP0006035_abnormal_mitochondrial_morpho1.33116978
53MP0003937_abnormal_limbs/digits/tail_de1.30933620
54MP0003763_abnormal_thymus_physiology1.28398079
55MP0002282_abnormal_trachea_morphology1.24195044
56MP0000703_abnormal_thymus_morphology1.23936390
57MP0003787_abnormal_imprinting1.22871357
58MP0003938_abnormal_ear_development1.22567319
59MP0003861_abnormal_nervous_system1.22505986
60MP0002086_abnormal_extraembryonic_tissu1.22200430
61MP0005174_abnormal_tail_pigmentation1.20910070
62MP0000313_abnormal_cell_death1.19205678
63MP0004133_heterotaxia1.19197448
64MP0002111_abnormal_tail_morphology1.18843314
65MP0003567_abnormal_fetal_cardiomyocyte1.17912948
66MP0003115_abnormal_respiratory_system1.16596294
67MP0003186_abnormal_redox_activity1.15517437
68MP0001727_abnormal_embryo_implantation1.14783979
69MP0010307_abnormal_tumor_latency1.14006677
70MP0003221_abnormal_cardiomyocyte_apopto1.13577237
71MP0001286_abnormal_eye_development1.12893978
72MP0002932_abnormal_joint_morphology1.12857860
73MP0002089_abnormal_postnatal_growth/wei1.12681925
74MP0003385_abnormal_body_wall1.09955070
75MP0002210_abnormal_sex_determination1.09919673
76MP0000372_irregular_coat_pigmentation1.09561409
77MP0003935_abnormal_craniofacial_develop1.06688789
78MP0000579_abnormal_nail_morphology1.04287677
79MP0002092_abnormal_eye_morphology1.04136102
80MP0001919_abnormal_reproductive_system1.04004168
81MP0005499_abnormal_olfactory_system1.03631247
82MP0005394_taste/olfaction_phenotype1.03631247
83MP0009379_abnormal_foot_pigmentation1.03572049
84MP0003283_abnormal_digestive_organ1.03392729
85MP0002249_abnormal_larynx_morphology1.03266859
86MP0003755_abnormal_palate_morphology1.01904790
87MP0009703_decreased_birth_body1.01799636
88MP0002277_abnormal_respiratory_mucosa1.01137222
89MP0009333_abnormal_splenocyte_physiolog1.01021498
90MP0002019_abnormal_tumor_incidence1.00932000
91MP0002697_abnormal_eye_size0.99033163
92MP0002116_abnormal_craniofacial_bone0.98948315
93MP0003942_abnormal_urinary_system0.96687508
94MP0001145_abnormal_male_reproductive0.95948195
95MP0002254_reproductive_system_inflammat0.95671974
96MP0002398_abnormal_bone_marrow0.94355765
97MP0005367_renal/urinary_system_phenotyp0.93569294
98MP0000516_abnormal_urinary_system0.93569294
99MP0003122_maternal_imprinting0.92113604
100MP0000647_abnormal_sebaceous_gland0.91909694
101MP0005389_reproductive_system_phenotype0.90687663
102MP0005257_abnormal_intraocular_pressure0.88166184
103MP0000653_abnormal_sex_gland0.87932072
104MP0000569_abnormal_digit_pigmentation0.86814023
105MP0000432_abnormal_head_morphology0.86811356
106MP0003786_premature_aging0.85985463
107MP0002233_abnormal_nose_morphology0.84814109
108MP0005084_abnormal_gallbladder_morpholo0.84430266
109MP0001929_abnormal_gametogenesis0.84260998
110MP0002081_perinatal_lethality0.83695016
111MP0003136_yellow_coat_color0.83296135
112MP0002234_abnormal_pharynx_morphology0.82879215
113MP0002736_abnormal_nociception_after0.82206353
114MP0006036_abnormal_mitochondrial_physio0.81384991
115MP0002114_abnormal_axial_skeleton0.80620338
116MP0004147_increased_porphyrin_level0.80265008
117MP0009250_abnormal_appendicular_skeleto0.80218596
118MP0002095_abnormal_skin_pigmentation0.80149789
119MP0009278_abnormal_bone_marrow0.80075059
120MP0001119_abnormal_female_reproductive0.79825810
121MP0000778_abnormal_nervous_system0.78094891
122MP0009672_abnormal_birth_weight0.77345081
123MP0000467_abnormal_esophagus_morphology0.76946423
124MP0000358_abnormal_cell_content/0.75271731
125MP0003941_abnormal_skin_development0.74921171
126MP0002177_abnormal_outer_ear0.74449435
127MP0005253_abnormal_eye_physiology0.74436357
128MP0005391_vision/eye_phenotype0.74344326
129MP0002722_abnormal_immune_system0.74293673
130MP0001849_ear_inflammation0.74182230
131MP0000733_abnormal_muscle_development0.73313906
132MP0002822_catalepsy0.72342506
133MP0000631_abnormal_neuroendocrine_gland0.71844264
134MP0005187_abnormal_penis_morphology0.71617519
135MP0001764_abnormal_homeostasis0.67651345
136MP0002160_abnormal_reproductive_system0.67460107
137MP0002429_abnormal_blood_cell0.66364362
138MP0005646_abnormal_pituitary_gland0.66102108

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)4.63422447
2Abnormal number of incisors (HP:0011064)3.32074063
3Acute necrotizing encephalopathy (HP:0006965)3.26269836
4Increased nuchal translucency (HP:0010880)3.22706118
5Abnormality of the labia minora (HP:0012880)3.17209443
6Abnormality of cells of the erythroid lineage (HP:0012130)3.05696206
7Colon cancer (HP:0003003)2.99683247
8Chromosomal breakage induced by crosslinking agents (HP:0003221)2.99298888
9Acute encephalopathy (HP:0006846)2.98747837
10Renal duplication (HP:0000075)2.97785076
11Ependymoma (HP:0002888)2.89772553
12Increased hepatocellular lipid droplets (HP:0006565)2.88400955
13Medulloblastoma (HP:0002885)2.86101469
14Selective tooth agenesis (HP:0001592)2.85042566
15Chromsome breakage (HP:0040012)2.83801786
16Abnormal number of erythroid precursors (HP:0012131)2.82100619
17Abnormal mitochondria in muscle tissue (HP:0008316)2.79768706
18Abnormality of the anterior horn cell (HP:0006802)2.78042182
19Degeneration of anterior horn cells (HP:0002398)2.78042182
20Patellar aplasia (HP:0006443)2.76291842
21High anterior hairline (HP:0009890)2.69960366
22Short 4th metacarpal (HP:0010044)2.66431441
23Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.66431441
24Lipid accumulation in hepatocytes (HP:0006561)2.65106900
25Aplasia/Hypoplasia of the patella (HP:0006498)2.65068191
26Proximal placement of thumb (HP:0009623)2.64099152
27Mitochondrial inheritance (HP:0001427)2.63839167
28Nephroblastoma (Wilms tumor) (HP:0002667)2.61197208
29Increased CSF lactate (HP:0002490)2.60825377
30Progressive macrocephaly (HP:0004481)2.59832496
31Embryonal renal neoplasm (HP:0011794)2.58214709
32Pallor (HP:0000980)2.57807577
33Hyperacusis (HP:0010780)2.52267591
34Cortical dysplasia (HP:0002539)2.51621111
35Deviation of the thumb (HP:0009603)2.44724387
36Oral leukoplakia (HP:0002745)2.42204592
37Cerebral edema (HP:0002181)2.39184403
38Horseshoe kidney (HP:0000085)2.38992479
39Septo-optic dysplasia (HP:0100842)2.37215625
40Ectopic kidney (HP:0000086)2.36389332
41Absent radius (HP:0003974)2.35539814
42Birth length less than 3rd percentile (HP:0003561)2.34422624
43Optic nerve coloboma (HP:0000588)2.29268540
44Aplasia/Hypoplasia of the uvula (HP:0010293)2.28953087
45Atresia of the external auditory canal (HP:0000413)2.28868477
46Aplasia involving forearm bones (HP:0009822)2.27864067
47Absent forearm bone (HP:0003953)2.27864067
48Aplasia/Hypoplasia of the sacrum (HP:0008517)2.24816044
49Stenosis of the external auditory canal (HP:0000402)2.24621972
50Hepatocellular necrosis (HP:0001404)2.22336323
51Overriding aorta (HP:0002623)2.21745284
523-Methylglutaconic aciduria (HP:0003535)2.20506681
53Hypoplasia of the pons (HP:0012110)2.17027209
54Abnormal lung lobation (HP:0002101)2.15783823
55Meckel diverticulum (HP:0002245)2.13363472
56Abnormality of the ileum (HP:0001549)2.12780922
57Triphalangeal thumb (HP:0001199)2.12419197
58Absent thumb (HP:0009777)2.12263656
59Abnormality of the pons (HP:0007361)2.11960310
60Microvesicular hepatic steatosis (HP:0001414)2.10940843
61Duplicated collecting system (HP:0000081)2.10684637
62Increased serum lactate (HP:0002151)2.10616530
63Abnormality of alanine metabolism (HP:0010916)2.10366618
64Hyperalaninemia (HP:0003348)2.10366618
65Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.10366618
6611 pairs of ribs (HP:0000878)2.08965659
67Macrocytic anemia (HP:0001972)2.08020318
68Multiple enchondromatosis (HP:0005701)2.06587565
69Abdominal situs inversus (HP:0003363)2.06142619
70Abnormality of abdominal situs (HP:0011620)2.06142619
71Rhabdomyosarcoma (HP:0002859)2.05445065
72Abnormality of the septum pellucidum (HP:0007375)2.05358770
73Breast hypoplasia (HP:0003187)2.05231181
74Glossoptosis (HP:0000162)2.03956039
75Elfin facies (HP:0004428)2.03899318
76Cutis marmorata (HP:0000965)2.03781138
77Hepatic necrosis (HP:0002605)2.03513209
78Small intestinal stenosis (HP:0012848)2.03373716
79Duodenal stenosis (HP:0100867)2.03373716
80Abnormality of the preputium (HP:0100587)2.02891581
81Bifid tongue (HP:0010297)2.02014226
82Tracheoesophageal fistula (HP:0002575)2.00800481
83Neoplasm of the pancreas (HP:0002894)2.00303161
84Absent septum pellucidum (HP:0001331)1.98723809
85Renovascular hypertension (HP:0100817)1.98070066
86Atrophy/Degeneration involving motor neurons (HP:0007373)1.97135517
87Abnormality of the intervertebral disk (HP:0005108)1.96762775
88Astrocytoma (HP:0009592)1.96575073
89Abnormality of the astrocytes (HP:0100707)1.96575073
90Agnosia (HP:0010524)1.96545561
91Shoulder girdle muscle weakness (HP:0003547)1.96160581
92Aplasia/Hypoplasia of the sternum (HP:0006714)1.96045497
93Hypoplastic pelvis (HP:0008839)1.95756848
94Abnormality of the carotid arteries (HP:0005344)1.95426985
95Trismus (HP:0000211)1.92786679
96Basal cell carcinoma (HP:0002671)1.91911669
97Duplication of thumb phalanx (HP:0009942)1.90165158
98Esophageal atresia (HP:0002032)1.89040956
99Increased serum pyruvate (HP:0003542)1.86785580
100Sloping forehead (HP:0000340)1.85558266
101Aplastic anemia (HP:0001915)1.84707273
102Neoplasm of striated muscle (HP:0009728)1.84494362
103Abnormality of the renal collecting system (HP:0004742)1.84328304
104Pendular nystagmus (HP:0012043)1.83454166
105Neoplasm of the adrenal cortex (HP:0100641)1.82203462
106Myelodysplasia (HP:0002863)1.82071295
107Lactic acidosis (HP:0003128)1.80245399
108Microretrognathia (HP:0000308)1.79875507
109Respiratory difficulties (HP:0002880)1.79815095
110Pelvic girdle muscle weakness (HP:0003749)1.79588261
111Volvulus (HP:0002580)1.79483327
112Hyperglycinemia (HP:0002154)1.78770116
113Abnormality of the duodenum (HP:0002246)1.78118402
114Abnormality of chromosome stability (HP:0003220)1.77960561
115Abnormality of DNA repair (HP:0003254)1.77275701
116Renal Fanconi syndrome (HP:0001994)1.76633688
117Aplasia/Hypoplasia of the spleen (HP:0010451)1.76236578
118Malignant gastrointestinal tract tumors (HP:0006749)1.75823757
119Gastrointestinal carcinoma (HP:0002672)1.75823757
120Abnormality of the 4th metacarpal (HP:0010012)1.74630400
121Facial cleft (HP:0002006)1.74029993
122Missing ribs (HP:0000921)1.73520111
123Abnormality of serum amino acid levels (HP:0003112)1.72640568
124Abnormal hair whorl (HP:0010721)1.72292951
125Leukodystrophy (HP:0002415)1.71039892
126Cleft eyelid (HP:0000625)1.70884151
127Insomnia (HP:0100785)1.70683604
128Skull defect (HP:0001362)1.70554674
129Preauricular skin tag (HP:0000384)1.69801366
130Small hand (HP:0200055)1.69740269
131Short thumb (HP:0009778)1.69221085
132Glioma (HP:0009733)1.68614191
133Pointed chin (HP:0000307)1.68284061
134Reduced antithrombin III activity (HP:0001976)1.67746154
135Cellular immunodeficiency (HP:0005374)1.67429869
136Abnormality of the incisor (HP:0000676)1.66387949
137True hermaphroditism (HP:0010459)1.65501968
138Amaurosis fugax (HP:0100576)1.65341743
139Decreased activity of mitochondrial respiratory chain (HP:0008972)1.65314235
140Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.65314235
141Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.64166523
142Abnormal protein N-linked glycosylation (HP:0012347)1.64166523
143Abnormal protein glycosylation (HP:0012346)1.64166523
144Abnormal glycosylation (HP:0012345)1.64166523
145Bicuspid aortic valve (HP:0001647)1.62944759
146Vaginal atresia (HP:0000148)1.62794381
147Gastrointestinal atresia (HP:0002589)1.62730191
148Skin tags (HP:0010609)1.61632334
149Molar tooth sign on MRI (HP:0002419)1.61555506
150Abnormality of midbrain morphology (HP:0002418)1.61555506
151Spina bifida occulta (HP:0003298)1.61554352
152Intestinal atresia (HP:0011100)1.61276416
153Premature graying of hair (HP:0002216)1.61183552
154Rough bone trabeculation (HP:0100670)1.61059992
155Acute lymphatic leukemia (HP:0006721)1.60717195
156Long eyelashes (HP:0000527)1.59860874
157Hemivertebrae (HP:0002937)1.59273543
158Preaxial hand polydactyly (HP:0001177)1.58572378
159Bilateral microphthalmos (HP:0007633)1.58304234

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.28889483
2CDC73.79238263
3VRK23.29974664
4TLK12.97588172
5MKNK12.68166078
6PASK2.66730179
7WEE12.59996263
8MAP3K102.55828697
9TAF12.54906871
10SRPK12.44002150
11NEK22.43658476
12EIF2AK12.30548610
13ZAK2.29461431
14TESK22.27614232
15TRIM282.27528775
16NUAK12.15199883
17MKNK22.08656447
18PBK2.07788278
19EEF2K2.02066905
20DYRK31.94434889
21RPS6KB21.89215345
22MST41.82224177
23CDK121.78174286
24CDK71.70207701
25WNK31.67619409
26ATR1.64168184
27STK161.60084625
28TSSK61.56066195
29VRK11.55670252
30PLK11.50091900
31TNIK1.49754174
32BRSK21.49570005
33TGFBR11.47945361
34BRD41.47781779
35EPHB21.47043769
36TTK1.41457432
37PAK41.39632024
38PKN21.39545192
39SCYL21.35573676
40AURKB1.34056212
41RPS6KA41.32722320
42PLK31.28852876
43KSR11.28507651
44PNCK1.26474749
45CCNB11.26193756
46BRSK11.25010479
47TESK11.22860241
48CHEK11.19829499
49NME11.19278278
50MAP3K41.19202098
51UHMK11.17965520
52PLK41.16500847
53AURKA1.15356611
54BMPR1B1.14868973
55MAP3K81.14144743
56EIF2AK21.12132489
57ACVR1B1.10779886
58CDK41.09570292
59NEK11.06253963
60CHEK21.04119153
61ERBB30.98467344
62FGFR10.98347977
63PDK20.98112310
64CLK10.97648236
65ICK0.97014196
66YES10.95753978
67SIK30.94839900
68LIMK10.94310615
69DYRK20.93702549
70STK100.91017776
71MAP2K70.89651245
72STK240.87080707
73MAP3K110.86618744
74CSNK1G10.85262703
75TAOK20.84661350
76CDK20.84085609
77KDR0.82760397
78STK38L0.82545787
79NME20.81094692
80CDK80.80217869
81PIM20.77067019
82ATM0.76121829
83STK30.75722464
84CSNK1G20.75408860
85DYRK1B0.75300555
86MAP4K10.73801101
87CSNK1G30.73398071
88ILK0.71004893
89BLK0.70938596
90CDK10.68196542
91CSNK1E0.66848822
92CDK30.65628582
93AKT20.64625466
94TRIB30.63279498
95BTK0.62607595
96ALK0.61742391
97LRRK20.60776410
98PAK10.59413035
99MUSK0.57856663
100PLK20.57345376
101MELK0.56774861
102PIM10.56404599
103EIF2AK30.56072967
104BCR0.55872336
105CDK60.51914161
106CSNK2A20.51689274
107STK40.51512024
108CSNK1A1L0.51168651
109CDK190.51039043
110CSNK2A10.50721894
111RPS6KA10.49875924
112ERBB40.48876872
113CASK0.48184311
114MAPK90.45347772
115GRK60.45098031
116PRKDC0.44375888
117IRAK20.44158192
118PRKCI0.43920636
119FLT30.43717535
120ERBB20.42728732
121MAP4K20.42683469
122ZAP700.42117486
123PTK60.41625300
124CAMK1G0.41474355
125IRAK40.41244793
126CDK180.40830263
127MTOR0.40616194
128RPS6KA50.40490101
129LATS10.37952503
130EPHA20.37889995
131CDK11A0.37451646
132MINK10.36437057
133CHUK0.36329515
134CDK140.35998690
135PAK20.35845280
136MAPKAPK20.35482036
137OXSR10.29894280
138GRK10.28643636
139PRKCG0.28331178
140CSNK1A10.27505484
141DMPK0.24869425
142CAMK1D0.23387303
143NLK0.23168687

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.64430972
2Spliceosome_Homo sapiens_hsa030403.81133809
3Mismatch repair_Homo sapiens_hsa034303.73025361
4Ribosome_Homo sapiens_hsa030103.35438977
5RNA transport_Homo sapiens_hsa030132.77601476
6Cell cycle_Homo sapiens_hsa041102.76993753
7Oxidative phosphorylation_Homo sapiens_hsa001902.73648027
8* Base excision repair_Homo sapiens_hsa034102.63785388
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.57632356
10Parkinsons disease_Homo sapiens_hsa050122.50605296
11Homologous recombination_Homo sapiens_hsa034402.43961385
12Nucleotide excision repair_Homo sapiens_hsa034202.38640769
13One carbon pool by folate_Homo sapiens_hsa006702.26638890
14RNA polymerase_Homo sapiens_hsa030202.23638803
15Proteasome_Homo sapiens_hsa030502.22564528
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.16323592
17mRNA surveillance pathway_Homo sapiens_hsa030152.16268766
18Selenocompound metabolism_Homo sapiens_hsa004501.94007963
19Huntingtons disease_Homo sapiens_hsa050161.92684938
20Fanconi anemia pathway_Homo sapiens_hsa034601.90479820
21Pyrimidine metabolism_Homo sapiens_hsa002401.84613754
22Steroid biosynthesis_Homo sapiens_hsa001001.81075649
23RNA degradation_Homo sapiens_hsa030181.76365963
24Basal cell carcinoma_Homo sapiens_hsa052171.62880195
25Cysteine and methionine metabolism_Homo sapiens_hsa002701.47516804
26Notch signaling pathway_Homo sapiens_hsa043301.46321366
27Non-homologous end-joining_Homo sapiens_hsa034501.43964120
28Alzheimers disease_Homo sapiens_hsa050101.42393748
29Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.38711796
30Propanoate metabolism_Homo sapiens_hsa006401.37852590
31Basal transcription factors_Homo sapiens_hsa030221.34435173
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.31994908
33p53 signaling pathway_Homo sapiens_hsa041151.31147745
34Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.29186198
35Epstein-Barr virus infection_Homo sapiens_hsa051691.24372430
36Pyruvate metabolism_Homo sapiens_hsa006201.22147994
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.20485455
38MicroRNAs in cancer_Homo sapiens_hsa052061.18769585
39HTLV-I infection_Homo sapiens_hsa051661.18549778
40Hedgehog signaling pathway_Homo sapiens_hsa043401.13235649
41Colorectal cancer_Homo sapiens_hsa052101.12559718
42Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.11435682
43Herpes simplex infection_Homo sapiens_hsa051681.09923492
44Hippo signaling pathway_Homo sapiens_hsa043901.09412006
45Viral carcinogenesis_Homo sapiens_hsa052031.08961753
46Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.07970295
47Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.06376116
48Fatty acid elongation_Homo sapiens_hsa000621.05918553
49Systemic lupus erythematosus_Homo sapiens_hsa053221.03441174
50Oocyte meiosis_Homo sapiens_hsa041141.03061459
51Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.95911440
52Chronic myeloid leukemia_Homo sapiens_hsa052200.95715410
53N-Glycan biosynthesis_Homo sapiens_hsa005100.94965961
54Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.94193575
55Viral myocarditis_Homo sapiens_hsa054160.90302216
56Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.90041064
57Thyroid cancer_Homo sapiens_hsa052160.87712424
58Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.86295228
59Transcriptional misregulation in cancer_Homo sapiens_hsa052020.85482437
60Cardiac muscle contraction_Homo sapiens_hsa042600.83592869
61Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.83499696
62Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.81286785
63Small cell lung cancer_Homo sapiens_hsa052220.81229059
64Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.81135872
65Purine metabolism_Homo sapiens_hsa002300.81089497
66Shigellosis_Homo sapiens_hsa051310.79267187
67Primary immunodeficiency_Homo sapiens_hsa053400.78564924
68Wnt signaling pathway_Homo sapiens_hsa043100.77915799
69Antigen processing and presentation_Homo sapiens_hsa046120.76951655
70Legionellosis_Homo sapiens_hsa051340.76831701
71Folate biosynthesis_Homo sapiens_hsa007900.73587831
72Hepatitis B_Homo sapiens_hsa051610.68849836
73Bladder cancer_Homo sapiens_hsa052190.68533145
74Apoptosis_Homo sapiens_hsa042100.66713253
75Endometrial cancer_Homo sapiens_hsa052130.66362816
76Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.65534571
77Central carbon metabolism in cancer_Homo sapiens_hsa052300.64735194
78T cell receptor signaling pathway_Homo sapiens_hsa046600.62603094
79Pathways in cancer_Homo sapiens_hsa052000.62411527
80Alcoholism_Homo sapiens_hsa050340.61872930
81Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.61454084
82Measles_Homo sapiens_hsa051620.61056843
83Protein export_Homo sapiens_hsa030600.60076411
84Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.58991550
85Metabolic pathways_Homo sapiens_hsa011000.58212601
86Acute myeloid leukemia_Homo sapiens_hsa052210.58168797
87TGF-beta signaling pathway_Homo sapiens_hsa043500.56823850
88Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.56550489
89Neurotrophin signaling pathway_Homo sapiens_hsa047220.53945048
90Glutathione metabolism_Homo sapiens_hsa004800.53112717
91Carbon metabolism_Homo sapiens_hsa012000.52733476
92Non-small cell lung cancer_Homo sapiens_hsa052230.52096452
93Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.49997015
94Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.49319815
952-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.49098545
96Sulfur metabolism_Homo sapiens_hsa009200.46388590
97NF-kappa B signaling pathway_Homo sapiens_hsa040640.44415320
98Pancreatic cancer_Homo sapiens_hsa052120.43507425
99Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.42985546
100Proteoglycans in cancer_Homo sapiens_hsa052050.42933504
101Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.40920855
102Leishmaniasis_Homo sapiens_hsa051400.40745363
103Influenza A_Homo sapiens_hsa051640.40718198
104Regulation of autophagy_Homo sapiens_hsa041400.40668174
105Butanoate metabolism_Homo sapiens_hsa006500.40090745
106HIF-1 signaling pathway_Homo sapiens_hsa040660.38569417
107Axon guidance_Homo sapiens_hsa043600.38296159
108Prostate cancer_Homo sapiens_hsa052150.38255527
109Phototransduction_Homo sapiens_hsa047440.38063027
110Adherens junction_Homo sapiens_hsa045200.38014659
111Sulfur relay system_Homo sapiens_hsa041220.36313075
112Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.35657675
113Vitamin digestion and absorption_Homo sapiens_hsa049770.35625318
114B cell receptor signaling pathway_Homo sapiens_hsa046620.34953458
115mTOR signaling pathway_Homo sapiens_hsa041500.33882603
116Melanoma_Homo sapiens_hsa052180.33808876
117PI3K-Akt signaling pathway_Homo sapiens_hsa041510.33652141
118AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.33514303
119Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.32917562
120Thyroid hormone signaling pathway_Homo sapiens_hsa049190.32114174
121Biosynthesis of amino acids_Homo sapiens_hsa012300.31607063
122VEGF signaling pathway_Homo sapiens_hsa043700.31251075
123Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.30680700
124Leukocyte transendothelial migration_Homo sapiens_hsa046700.30522654
125NOD-like receptor signaling pathway_Homo sapiens_hsa046210.30310018
126Renal cell carcinoma_Homo sapiens_hsa052110.30135648
127Fatty acid metabolism_Homo sapiens_hsa012120.30074888
128Pentose phosphate pathway_Homo sapiens_hsa000300.28437593
129Intestinal immune network for IgA production_Homo sapiens_hsa046720.28137723
130Vitamin B6 metabolism_Homo sapiens_hsa007500.27947205
131Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.27939997
132Cyanoamino acid metabolism_Homo sapiens_hsa004600.27823039
133Tight junction_Homo sapiens_hsa045300.27120903
134Melanogenesis_Homo sapiens_hsa049160.26716882
135Allograft rejection_Homo sapiens_hsa053300.26596699
136Toxoplasmosis_Homo sapiens_hsa051450.25960940
137Lysine degradation_Homo sapiens_hsa003100.17483940
138Peroxisome_Homo sapiens_hsa041460.16398634
139Tryptophan metabolism_Homo sapiens_hsa003800.11344232
140Pentose and glucuronate interconversions_Homo sapiens_hsa000400.10847484
141Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.09622786
142Ether lipid metabolism_Homo sapiens_hsa005650.08445896
143Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.08122034
144Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.06564140
145Collecting duct acid secretion_Homo sapiens_hsa049660.02636544
146Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.02205617
147Fatty acid degradation_Homo sapiens_hsa000710.02200044
148Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.01862136

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