TDGF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an epidermal growth factor-related protein that contains a cripto, FRL-1, and cryptic domain. The encoded protein is an extracellular, membrane-bound signaling protein that plays an essential role in embryonic development and tumor growth. Mutations in this gene are associated with forebrain defects. Pseudogenes of this gene are found on chromosomes 2, 3, 6, 8, 19 and X. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of gene silencing by RNA (GO:0060966)5.97729308
2regulation of posttranscriptional gene silencing (GO:0060147)5.97729308
3regulation of gene silencing by miRNA (GO:0060964)5.97729308
4nuclear pore organization (GO:0006999)5.45757625
5nuclear pore complex assembly (GO:0051292)5.04315454
6regulation of helicase activity (GO:0051095)5.01076966
7L-serine metabolic process (GO:0006563)4.86882888
8IMP biosynthetic process (GO:0006188)4.73327361
9nucleobase biosynthetic process (GO:0046112)4.72471604
10DNA replication initiation (GO:0006270)4.70548839
11folic acid-containing compound biosynthetic process (GO:0009396)4.65719492
12DNA unwinding involved in DNA replication (GO:0006268)4.56724459
13DNA replication-dependent nucleosome organization (GO:0034723)4.51168261
14DNA replication-dependent nucleosome assembly (GO:0006335)4.51168261
15somatic diversification of immune receptors via somatic mutation (GO:0002566)4.47620061
16somatic hypermutation of immunoglobulin genes (GO:0016446)4.47620061
17establishment of viral latency (GO:0019043)4.41287722
18purine nucleobase biosynthetic process (GO:0009113)4.41122163
19mitotic metaphase plate congression (GO:0007080)4.35562590
20ribosome assembly (GO:0042255)4.30103046
21negative regulation of DNA-dependent DNA replication (GO:2000104)4.27448433
22regulation of mitotic spindle checkpoint (GO:1903504)4.25468207
23regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)4.25468207
24mitotic nuclear envelope disassembly (GO:0007077)4.19088755
25DNA double-strand break processing (GO:0000729)4.17552826
26protein localization to kinetochore (GO:0034501)4.11432117
27IMP metabolic process (GO:0046040)4.11049518
28DNA strand elongation involved in DNA replication (GO:0006271)4.10969689
29formation of translation preinitiation complex (GO:0001731)4.07491780
30regulation of histone H3-K9 methylation (GO:0051570)4.06209133
31determination of adult lifespan (GO:0008340)4.01445379
32negative regulation of histone methylation (GO:0031061)3.96077458
33maturation of SSU-rRNA (GO:0030490)3.92437322
34nuclear envelope disassembly (GO:0051081)3.90752148
35membrane disassembly (GO:0030397)3.90752148
36negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.90604589
37DNA strand elongation (GO:0022616)3.88653666
38protein complex localization (GO:0031503)3.88053151
39pore complex assembly (GO:0046931)3.81728051
40ribosome biogenesis (GO:0042254)3.81613513
41protein K6-linked ubiquitination (GO:0085020)3.80726127
42metaphase plate congression (GO:0051310)3.77891742
43pre-miRNA processing (GO:0031054)3.67016609
44DNA replication checkpoint (GO:0000076)3.65427729
45regulation of gene silencing (GO:0060968)3.62736222
46DNA geometric change (GO:0032392)3.60726071
47female gonad development (GO:0008585)3.60670077
48DNA duplex unwinding (GO:0032508)3.60249946
49heterochromatin organization (GO:0070828)3.58777856
50paraxial mesoderm development (GO:0048339)3.57612253
51telomere maintenance via semi-conservative replication (GO:0032201)3.55893191
52chromatin remodeling at centromere (GO:0031055)3.52584194
53proteasome assembly (GO:0043248)3.51630849
54positive regulation of SMAD protein import into nucleus (GO:0060391)3.50143866
55regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.47775586
56regulation of mitotic metaphase/anaphase transition (GO:0030071)3.47775586
57telomere maintenance via telomerase (GO:0007004)3.46149341
58regulation of translational fidelity (GO:0006450)3.43129259
59establishment of integrated proviral latency (GO:0075713)3.42246895
60ribonucleoprotein complex biogenesis (GO:0022613)3.42185188
61mitotic spindle assembly checkpoint (GO:0007094)3.39252124
62mitotic G2/M transition checkpoint (GO:0044818)3.37405133
63ATP-dependent chromatin remodeling (GO:0043044)3.36987368
64lysine catabolic process (GO:0006554)3.35961091
65lysine metabolic process (GO:0006553)3.35961091
66negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.35509357
67negative regulation of translation, ncRNA-mediated (GO:0040033)3.35509357
68regulation of translation, ncRNA-mediated (GO:0045974)3.35509357
69regulation of spindle organization (GO:0090224)3.35202670
70non-recombinational repair (GO:0000726)3.35196277
71double-strand break repair via nonhomologous end joining (GO:0006303)3.35196277
72negative regulation of gene silencing (GO:0060969)3.34927688
73negative regulation of telomerase activity (GO:0051974)3.34355364
74positive regulation of chromosome segregation (GO:0051984)3.33327446
75protein localization to chromosome, centromeric region (GO:0071459)3.32582628
76mitotic sister chromatid segregation (GO:0000070)3.32088949
77regulation of sister chromatid segregation (GO:0033045)3.31473911
78regulation of mitotic sister chromatid separation (GO:0010965)3.31473911
79regulation of mitotic sister chromatid segregation (GO:0033047)3.31473911
80ribosomal large subunit biogenesis (GO:0042273)3.31363255
81DNA damage response, detection of DNA damage (GO:0042769)3.31200951
82spindle assembly checkpoint (GO:0071173)3.31195607
83regulation of mitotic spindle organization (GO:0060236)3.30248544
84negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.30190781
85response to X-ray (GO:0010165)3.29937882
86DNA ligation (GO:0006266)3.29662020
87establishment of chromosome localization (GO:0051303)3.29379084
88histone arginine methylation (GO:0034969)3.29297675
89regulation of translational termination (GO:0006449)3.27574269
90regulation of centrosome cycle (GO:0046605)3.25802469
91regulation of nuclear cell cycle DNA replication (GO:0033262)3.25769964
92chaperone-mediated protein complex assembly (GO:0051131)3.24934650
93CENP-A containing nucleosome assembly (GO:0034080)3.24030954
94regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.23628631
95negative regulation of mitosis (GO:0045839)3.21114869
96regulation of mesoderm development (GO:2000380)3.21031589
97histone H4-K12 acetylation (GO:0043983)3.19314259
98telomere maintenance via telomere lengthening (GO:0010833)3.19256912
99regulation of cell fate specification (GO:0042659)3.18894708
100regulation of telomere maintenance via telomerase (GO:0032210)3.18682349
101somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.18514017
102isotype switching (GO:0045190)3.18514017
103somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.18514017
104regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.16369944
105mismatch repair (GO:0006298)3.15955172
106telomere maintenance via recombination (GO:0000722)3.15318664
107RNA-dependent DNA replication (GO:0006278)3.13861489
108DNA replication-independent nucleosome organization (GO:0034724)3.13498697
109DNA replication-independent nucleosome assembly (GO:0006336)3.13498697
110L-alpha-amino acid transmembrane transport (GO:1902475)3.11897862
111mitotic sister chromatid cohesion (GO:0007064)3.11831256
112regulation of centriole replication (GO:0046599)3.11666914
113mitotic recombination (GO:0006312)3.11133282
114kinetochore organization (GO:0051383)3.09838905
115DNA catabolic process, exonucleolytic (GO:0000738)3.09504931
116histone H2A monoubiquitination (GO:0035518)3.06818146
117rRNA processing (GO:0006364)3.06662763
118regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.04871534
119negative regulation of chromosome segregation (GO:0051985)3.03541187
120negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.02058278
121negative regulation of ligase activity (GO:0051352)3.02058278
122mitotic chromosome condensation (GO:0007076)3.01266846
123spliceosomal snRNP assembly (GO:0000387)3.01078722
124serine family amino acid biosynthetic process (GO:0009070)3.00998554
125histone exchange (GO:0043486)3.00770802
126cellular protein complex localization (GO:0034629)2.99587102
127rRNA metabolic process (GO:0016072)2.97052302
128negative regulation of androgen receptor signaling pathway (GO:0060766)2.96957599
129sister chromatid segregation (GO:0000819)2.96953909
130DNA strand renaturation (GO:0000733)2.96474749
131regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.96342422
132nodal signaling pathway (GO:0038092)2.96057289
133attachment of spindle microtubules to kinetochore (GO:0008608)2.95355422
134negative regulation of DNA recombination (GO:0045910)2.94677120
135peptidyl-arginine omega-N-methylation (GO:0035247)2.94382271
136negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.94248717
137negative regulation of sister chromatid segregation (GO:0033046)2.94248717
138negative regulation of mitotic sister chromatid separation (GO:2000816)2.94248717
139negative regulation of mitotic sister chromatid segregation (GO:0033048)2.94248717
140nucleotide-excision repair, DNA gap filling (GO:0006297)2.93938725
141intra-S DNA damage checkpoint (GO:0031573)2.93704324
142regulation of chromosome segregation (GO:0051983)2.93648978
143chromatin assembly or disassembly (GO:0006333)2.92942656
144histone mRNA metabolic process (GO:0008334)2.92008027
145tetrahydrofolate metabolic process (GO:0046653)2.89951260
146anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.89214794
147spindle checkpoint (GO:0031577)2.88861238
148nuclear envelope organization (GO:0006998)2.88562263
149tRNA aminoacylation for protein translation (GO:0006418)2.87083113
150establishment of protein localization to mitochondrial membrane (GO:0090151)2.86984947
151chromatin assembly (GO:0031497)2.86962246
152mitotic spindle checkpoint (GO:0071174)2.85931108

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.79367574
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.19722755
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.73993311
4MYC_19079543_ChIP-ChIP_MESCs_Mouse3.39726262
5KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.38543742
6KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.38543742
7KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.38543742
8E2F4_17652178_ChIP-ChIP_JURKAT_Human3.35622177
9* SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.99474771
10* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.93778365
11MYC_19030024_ChIP-ChIP_MESCs_Mouse2.83596547
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.74850516
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.64647443
14* NANOG_18555785_ChIP-Seq_MESCs_Mouse2.53190577
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.50259818
16* NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.45448003
17NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.43938404
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.34330121
19NELFA_20434984_ChIP-Seq_ESCs_Mouse2.32413308
20KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.32337321
21* POU5F1_16153702_ChIP-ChIP_HESCs_Human2.27881393
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.27636591
23* TCF3_18692474_ChIP-Seq_MEFs_Mouse2.25714900
24* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.23473245
25SALL1_21062744_ChIP-ChIP_HESCs_Human2.23047605
26EST1_17652178_ChIP-ChIP_JURKAT_Human2.20664021
27POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.17554361
28* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse2.11862339
29KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.09649490
30ETS1_20019798_ChIP-Seq_JURKAT_Human2.06617604
31* STAT3_1855785_ChIP-Seq_MESCs_Mouse2.02808521
32* SOX2_18555785_ChIP-Seq_MESCs_Mouse1.98363899
33XRN2_22483619_ChIP-Seq_HELA_Human1.96760289
34MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.94716721
35EGR1_19374776_ChIP-ChIP_THP-1_Human1.93897672
36HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.93833384
37JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.93554440
38* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.93377435
39ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.92428673
40E2F1_18555785_ChIP-Seq_MESCs_Mouse1.92411349
41CREB1_15753290_ChIP-ChIP_HEK293T_Human1.91084133
42MYCN_18555785_ChIP-Seq_MESCs_Mouse1.84940617
43* SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.83196976
44* SOX2_16153702_ChIP-ChIP_HESCs_Human1.82569504
45* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.80256408
46GABP_17652178_ChIP-ChIP_JURKAT_Human1.78298348
47AR_21909140_ChIP-Seq_LNCAP_Human1.76806212
48E2F1_21310950_ChIP-Seq_MCF-7_Human1.71848157
49* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.70738200
50SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.66477254
51* NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.63905625
52ESR1_15608294_ChIP-ChIP_MCF-7_Human1.59630160
53FLI1_27457419_Chip-Seq_LIVER_Mouse1.57273604
54VDR_23849224_ChIP-Seq_CD4+_Human1.54368700
55* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.53405816
56* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.48936354
57THAP11_20581084_ChIP-Seq_MESCs_Mouse1.48117053
58* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.46717085
59* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.44197876
60TTF2_22483619_ChIP-Seq_HELA_Human1.43705266
61EWS_26573619_Chip-Seq_HEK293_Human1.43578368
62MYC_18940864_ChIP-ChIP_HL60_Human1.43350167
63* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.42592508
64YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.38492762
65* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.34666859
66* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.34537840
67FOXP3_21729870_ChIP-Seq_TREG_Human1.34082318
68DCP1A_22483619_ChIP-Seq_HELA_Human1.33945504
69YY1_21170310_ChIP-Seq_MESCs_Mouse1.33907870
70* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.32688970
71HOXB4_20404135_ChIP-ChIP_EML_Mouse1.32525573
72* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.31250089
73* POU5F1_16518401_ChIP-PET_MESCs_Mouse1.30650457
74ZNF274_21170338_ChIP-Seq_K562_Hela1.26479729
75* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.25249213
76GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.24964994
77* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.24626950
78GABP_19822575_ChIP-Seq_HepG2_Human1.24085953
79* NANOG_21062744_ChIP-ChIP_HESCs_Human1.23145068
80FUS_26573619_Chip-Seq_HEK293_Human1.22609969
81HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.21920712
82PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21377300
83* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.19610348
84VDR_22108803_ChIP-Seq_LS180_Human1.18317379
85GATA1_26923725_Chip-Seq_HPCs_Mouse1.15823371
86PCGF2_27294783_Chip-Seq_ESCs_Mouse1.13566900
87* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.13177651
88KDM5A_27292631_Chip-Seq_BREAST_Human1.12517031
89MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.12358858
90ELK1_19687146_ChIP-ChIP_HELA_Human1.11798671
91HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.11326245
92SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.10703028
93* P300_19829295_ChIP-Seq_ESCs_Human1.10185236
94NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.08971332
95NOTCH1_21737748_ChIP-Seq_TLL_Human1.08298205
96* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.06419455
97TP63_19390658_ChIP-ChIP_HaCaT_Human1.05236964
98KAP1_27257070_Chip-Seq_ESCs_Mouse1.02714252
99CIITA_25753668_ChIP-Seq_RAJI_Human1.02603882
100CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.02601718
101MYC_22102868_ChIP-Seq_BL_Human1.02589666
102* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.00180198
103TFEB_21752829_ChIP-Seq_HELA_Human0.98708680
104SRF_21415370_ChIP-Seq_HL-1_Mouse0.97702534
105* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.97678837
106DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.97299919
107FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.96527051
108ZNF263_19887448_ChIP-Seq_K562_Human0.95583568
109PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.94825962
110CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.94288532
111SOX17_20123909_ChIP-Seq_XEN_Mouse0.94070719
112GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.93457520
113E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.92996498
114CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.91657852
115PADI4_21655091_ChIP-ChIP_MCF-7_Human0.90356480
116TBX3_20139965_ChIP-Seq_ESCs_Mouse0.89733488
117* NANOG_16518401_ChIP-PET_MESCs_Mouse0.89614023
118TBX3_20139965_ChIP-Seq_MESCs_Mouse0.88563037
119RBPJ_22232070_ChIP-Seq_NCS_Mouse0.87935049
120* NANOG_16153702_ChIP-ChIP_HESCs_Human0.87770625
121CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.87053742
122HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.84891479
123TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.84016613
124FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.82411312
125PCGF2_27294783_Chip-Seq_NPCs_Mouse0.81103540
126SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.81054677
127PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.80587171
128DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.80472999

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat4.64050833
2MP0003693_abnormal_embryo_hatching4.63484544
3MP0004957_abnormal_blastocyst_morpholog4.56668588
4MP0010094_abnormal_chromosome_stability4.36353841
5MP0003111_abnormal_nucleus_morphology4.22866056
6MP0008057_abnormal_DNA_replication4.10618463
7MP0003806_abnormal_nucleotide_metabolis4.04573147
8MP0003077_abnormal_cell_cycle3.73595437
9MP0008058_abnormal_DNA_repair3.20956692
10MP0004133_heterotaxia3.16295722
11MP0010352_gastrointestinal_tract_polyps2.80939267
12MP0003123_paternal_imprinting2.79415589
13MP0001730_embryonic_growth_arrest2.71044023
14MP0008932_abnormal_embryonic_tissue2.60111788
15MP0002653_abnormal_ependyma_morphology2.56766436
16MP0003890_abnormal_embryonic-extraembry2.47841441
17* MP0000350_abnormal_cell_proliferation2.32711593
18MP0001188_hyperpigmentation2.30681537
19MP0003283_abnormal_digestive_organ2.21903324
20MP0008007_abnormal_cellular_replicative2.21862489
21MP0001672_abnormal_embryogenesis/_devel2.11493170
22MP0005380_embryogenesis_phenotype2.11493170
23MP0010307_abnormal_tumor_latency2.11282208
24* MP0002084_abnormal_developmental_patter2.09758160
25MP0003941_abnormal_skin_development2.02779694
26* MP0002085_abnormal_embryonic_tissue2.01186062
27MP0008877_abnormal_DNA_methylation2.01148441
28MP0001697_abnormal_embryo_size1.96154130
29MP0003119_abnormal_digestive_system1.94432097
30MP0003136_yellow_coat_color1.90104176
31MP0004197_abnormal_fetal_growth/weight/1.88948545
32MP0003718_maternal_effect1.83131182
33* MP0002086_abnormal_extraembryonic_tissu1.77963381
34MP0003984_embryonic_growth_retardation1.77634964
35MP0001293_anophthalmia1.75229519
36MP0002088_abnormal_embryonic_growth/wei1.74838172
37MP0003786_premature_aging1.71119319
38* MP0002080_prenatal_lethality1.69120676
39MP0005076_abnormal_cell_differentiation1.61817468
40MP0002102_abnormal_ear_morphology1.46033422
41MP0003121_genomic_imprinting1.44523991
42MP0010030_abnormal_orbit_morphology1.42564452
43MP0006292_abnormal_olfactory_placode1.41325617
44MP0003567_abnormal_fetal_cardiomyocyte1.39721131
45MP0005394_taste/olfaction_phenotype1.36559034
46MP0005499_abnormal_olfactory_system1.36559034
47MP0002736_abnormal_nociception_after1.29169567
48MP0000579_abnormal_nail_morphology1.28649191
49MP0003705_abnormal_hypodermis_morpholog1.28111174
50MP0005367_renal/urinary_system_phenotyp1.25121574
51MP0000516_abnormal_urinary_system1.25121574
52MP0002210_abnormal_sex_determination1.21168266
53MP0001177_atelectasis1.20307947
54MP0000313_abnormal_cell_death1.19228870
55MP0006035_abnormal_mitochondrial_morpho1.18459605
56MP0003315_abnormal_perineum_morphology1.16572181
57MP0005266_abnormal_metabolism1.15231204
58MP0001849_ear_inflammation1.14889278
59MP0009697_abnormal_copulation1.13936696
60MP0002111_abnormal_tail_morphology1.13719209
61MP0001145_abnormal_male_reproductive1.13584978
62MP0000537_abnormal_urethra_morphology1.11594024
63MP0002938_white_spotting1.10376859
64MP0003937_abnormal_limbs/digits/tail_de1.05872783
65MP0002233_abnormal_nose_morphology1.02702320
66MP0002019_abnormal_tumor_incidence1.01281268
67MP0009053_abnormal_anal_canal1.00919780
68MP0001984_abnormal_olfaction0.99696138
69MP0000490_abnormal_crypts_of0.99486266
70MP0003122_maternal_imprinting0.98804189
71MP0001529_abnormal_vocalization0.97873015
72MP0010234_abnormal_vibrissa_follicle0.97398833
73MP0002160_abnormal_reproductive_system0.94706354
74MP0008789_abnormal_olfactory_epithelium0.93466384
75MP0000049_abnormal_middle_ear0.93239006
76MP0002751_abnormal_autonomic_nervous0.93157576
77MP0003195_calcinosis0.90527059
78MP0009703_decreased_birth_body0.90347569
79* MP0003861_abnormal_nervous_system0.88467221
80MP0009672_abnormal_birth_weight0.88135442
81MP0001929_abnormal_gametogenesis0.88126880
82MP0000653_abnormal_sex_gland0.88030686
83MP0002090_abnormal_vision0.85992044
84MP0002697_abnormal_eye_size0.84584350
85MP0003936_abnormal_reproductive_system0.84378658
86* MP0001286_abnormal_eye_development0.82451626
87MP0005023_abnormal_wound_healing0.80949167
88MP0005501_abnormal_skin_physiology0.80944081
89MP0003186_abnormal_redox_activity0.79475803
90MP0000432_abnormal_head_morphology0.78649676
91MP0003950_abnormal_plasma_membrane0.76908972
92MP0000358_abnormal_cell_content/0.76821090
93MP0003137_abnormal_impulse_conducting0.76103957
94MP0004264_abnormal_extraembryonic_tissu0.75477377
95MP0005389_reproductive_system_phenotype0.74900920
96MP0002092_abnormal_eye_morphology0.73854244
97* MP0005384_cellular_phenotype0.73584794
98MP0006072_abnormal_retinal_apoptosis0.71651751
99MP0002127_abnormal_cardiovascular_syste0.67396111
100* MP0005621_abnormal_cell_physiology0.66327884
101MP0001915_intracranial_hemorrhage0.65527400
102* MP0003566_abnormal_cell_adhesion0.65269901
103MP0002277_abnormal_respiratory_mucosa0.65089780
104MP0003221_abnormal_cardiomyocyte_apopto0.64622666
105MP0002796_impaired_skin_barrier0.63536199
106MP0005623_abnormal_meninges_morphology0.63238619
107MP0001299_abnormal_eye_distance/0.62770168
108MP0003787_abnormal_imprinting0.62664051
109MP0008770_decreased_survivor_rate0.62611055
110MP0000647_abnormal_sebaceous_gland0.61933383
111MP0000762_abnormal_tongue_morphology0.61820791
112MP0000428_abnormal_craniofacial_morphol0.61800654
113MP0001485_abnormal_pinna_reflex0.61281746
114MP0005395_other_phenotype0.59519909
115MP0006036_abnormal_mitochondrial_physio0.59392373
116* MP0002925_abnormal_cardiovascular_devel0.59341378
117MP0002396_abnormal_hematopoietic_system0.58670850
118MP0002249_abnormal_larynx_morphology0.58427014
119MP0000477_abnormal_intestine_morphology0.57561866
120MP0003698_abnormal_male_reproductive0.56035874
121MP0001119_abnormal_female_reproductive0.55691466
122MP0004233_abnormal_muscle_weight0.55590785
123MP0000371_diluted_coat_color0.55488083
124MP0004215_abnormal_myocardial_fiber0.54745510
125MP0002269_muscular_atrophy0.54647853
126MP0008995_early_reproductive_senescence0.53359718
127MP0003935_abnormal_craniofacial_develop0.51942876
128MP0002161_abnormal_fertility/fecundity0.51751445
129MP0004272_abnormal_basement_membrane0.51649145
130MP0003755_abnormal_palate_morphology0.51220531
131MP0005391_vision/eye_phenotype0.50093286

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)5.76287203
2Abnormality of the labia minora (HP:0012880)4.74145068
3Birth length less than 3rd percentile (HP:0003561)4.44741764
4Agnosia (HP:0010524)4.32620562
5Medulloblastoma (HP:0002885)4.30111412
6Supernumerary spleens (HP:0009799)4.03539843
7Astrocytoma (HP:0009592)3.99091051
8Abnormality of the astrocytes (HP:0100707)3.99091051
9Absent radius (HP:0003974)3.95978739
10Breast hypoplasia (HP:0003187)3.95880617
11Colon cancer (HP:0003003)3.84023537
12Neoplasm of the oral cavity (HP:0100649)3.80205158
13Absent forearm bone (HP:0003953)3.72317499
14Aplasia involving forearm bones (HP:0009822)3.72317499
15Chromsome breakage (HP:0040012)3.53471199
16Rhabdomyosarcoma (HP:0002859)3.50139642
17Multiple enchondromatosis (HP:0005701)3.47803297
18Carpal bone hypoplasia (HP:0001498)3.47624980
19Chromosomal breakage induced by crosslinking agents (HP:0003221)3.44940891
20Selective tooth agenesis (HP:0001592)3.44245583
21Abnormal lung lobation (HP:0002101)3.44092678
22Aplasia/hypoplasia of the humerus (HP:0006507)3.36264123
23Glioma (HP:0009733)3.33266785
24Abdominal situs inversus (HP:0003363)3.22765231
25Abnormality of abdominal situs (HP:0011620)3.22765231
26Nephroblastoma (Wilms tumor) (HP:0002667)3.20058943
27Embryonal renal neoplasm (HP:0011794)3.14665104
28Short humerus (HP:0005792)3.14582732
29Biliary tract neoplasm (HP:0100574)3.14380290
30Reticulocytopenia (HP:0001896)3.05402571
31Impulsivity (HP:0100710)3.04897503
32Missing ribs (HP:0000921)3.00437489
33Oral leukoplakia (HP:0002745)2.97322749
34Esophageal atresia (HP:0002032)2.94351167
35Stenosis of the external auditory canal (HP:0000402)2.93138592
36Patellar aplasia (HP:0006443)2.91288908
37Rib fusion (HP:0000902)2.90374018
38Absent thumb (HP:0009777)2.89692640
39Abnormality of serum amino acid levels (HP:0003112)2.81186616
40Abnormality of the salivary glands (HP:0010286)2.79623373
41Pancreatic islet-cell hyperplasia (HP:0004510)2.75897078
42Neoplasm of striated muscle (HP:0009728)2.75892074
43Abnormality of chromosome stability (HP:0003220)2.75137642
44Rectal fistula (HP:0100590)2.68763485
45Rectovaginal fistula (HP:0000143)2.68763485
46Cortical dysplasia (HP:0002539)2.67987387
47Shawl scrotum (HP:0000049)2.66273716
48Aplasia/Hypoplasia of the patella (HP:0006498)2.64633155
49Meckel diverticulum (HP:0002245)2.64626783
50Hyperglycinemia (HP:0002154)2.64317615
51Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.61982658
52Hypoglycemic seizures (HP:0002173)2.59306178
53Abnormal hair whorl (HP:0010721)2.58076129
54Abnormality of serine family amino acid metabolism (HP:0010894)2.57458307
55Abnormality of glycine metabolism (HP:0010895)2.57458307
56Asplenia (HP:0001746)2.57349983
57Neoplasm of the adrenal gland (HP:0100631)2.55515978
58Degeneration of anterior horn cells (HP:0002398)2.55408798
59Abnormality of the anterior horn cell (HP:0006802)2.55408798
60Bilateral microphthalmos (HP:0007633)2.55264182
61Aplasia/Hypoplasia of the uvula (HP:0010293)2.54967471
62Basal cell carcinoma (HP:0002671)2.54263846
63Abnormality of the preputium (HP:0100587)2.53094984
64Abnormal number of incisors (HP:0011064)2.52732384
65Abnormality of the ileum (HP:0001549)2.51892621
66Amaurosis fugax (HP:0100576)2.49929029
67Cerebral hypomyelination (HP:0006808)2.49531541
68Abnormality of the septum pellucidum (HP:0007375)2.46484005
69Absent septum pellucidum (HP:0001331)2.45400792
70Hyperglycinuria (HP:0003108)2.44398197
71Abnormality of methionine metabolism (HP:0010901)2.43588301
72Neoplasm of the pancreas (HP:0002894)2.43141677
73Abnormality of aspartate family amino acid metabolism (HP:0010899)2.43081355
74Horseshoe kidney (HP:0000085)2.39254876
75Rough bone trabeculation (HP:0100670)2.38616467
76Hypoplastic female external genitalia (HP:0012815)2.37470051
77Abnormality of homocysteine metabolism (HP:0010919)2.37235056
78Homocystinuria (HP:0002156)2.37235056
79Abnormality of pyrimidine metabolism (HP:0004353)2.36734656
80Bifid tongue (HP:0010297)2.33092534
81Duplicated collecting system (HP:0000081)2.30070043
82Proximal placement of thumb (HP:0009623)2.29490244
83Aplasia/Hypoplasia of the spleen (HP:0010451)2.29343885
84Breast aplasia (HP:0100783)2.28863935
85Anal stenosis (HP:0002025)2.27959906
86Gonadotropin excess (HP:0000837)2.27759797
87Intestinal fistula (HP:0100819)2.27023649
88Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.25474152
89Methylmalonic acidemia (HP:0002912)2.24653208
90Deviation of the thumb (HP:0009603)2.24495872
91Gastrointestinal atresia (HP:0002589)2.22833311
92Hepatoblastoma (HP:0002884)2.21048986
93Supernumerary bones of the axial skeleton (HP:0009144)2.20790465
94Vaginal fistula (HP:0004320)2.20693541
95Labial hypoplasia (HP:0000066)2.20583854
96Tracheoesophageal fistula (HP:0002575)2.20421134
97Chronic bronchitis (HP:0004469)2.19917578
98Adenoma sebaceum (HP:0009720)2.17437362
99Angiofibromas (HP:0010615)2.17437362
100Intestinal atresia (HP:0011100)2.17118107
101Choanal stenosis (HP:0000452)2.14046567
102Vertebral clefting (HP:0008428)2.13971777
103Small intestinal stenosis (HP:0012848)2.12636432
104Duodenal stenosis (HP:0100867)2.12636432
105Ectopic kidney (HP:0000086)2.08114009
106Ovarian neoplasm (HP:0100615)2.06961853
107Abnormality of the clitoris (HP:0000056)2.06046910
108Aplasia/Hypoplasia of the sternum (HP:0006714)2.05571905
109Triphalangeal thumb (HP:0001199)2.05206879
110Fused cervical vertebrae (HP:0002949)2.05164116
111Neoplasm of the colon (HP:0100273)2.04760740
112Hyperinsulinemic hypoglycemia (HP:0000825)2.04399620
113Abnormality of the fetal cardiovascular system (HP:0010948)2.03989813
114Abnormal umbilical cord blood vessels (HP:0011403)2.03989813
115Single umbilical artery (HP:0001195)2.03989813
116Neoplasm of the adrenal cortex (HP:0100641)2.03770031
117Aplasia/Hypoplasia of the breasts (HP:0010311)2.03438965
118Supernumerary ribs (HP:0005815)2.02378788
119Myelomeningocele (HP:0002475)2.02367554
12011 pairs of ribs (HP:0000878)2.02265526
121Gastrointestinal carcinoma (HP:0002672)2.02178110
122Malignant gastrointestinal tract tumors (HP:0006749)2.02178110
123Abnormality of the duodenum (HP:0002246)2.02034232
124Abnormal biliary tract morphology (HP:0012440)2.00019460
125Sloping forehead (HP:0000340)1.99765952
126Volvulus (HP:0002580)1.99107895
127Myelodysplasia (HP:0002863)1.97106843
128Cellular immunodeficiency (HP:0005374)1.96908480
129Neoplasm of the rectum (HP:0100743)1.95371871
130Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.95056365
131Short 1st metacarpal (HP:0010034)1.95056365
132Methylmalonic aciduria (HP:0012120)1.94328341
133Abnormality of the parathyroid morphology (HP:0011766)1.94133273
134Progressive inability to walk (HP:0002505)1.92772765
135Delayed puberty (HP:0000823)1.92698289
136Trismus (HP:0000211)1.91863828
137Cafe-au-lait spot (HP:0000957)1.91519397
138Hypoplastic pelvis (HP:0008839)1.91251150
139Short thumb (HP:0009778)1.90170757
140Spastic diplegia (HP:0001264)1.89806999
141Septo-optic dysplasia (HP:0100842)1.89630121
142Hemivertebrae (HP:0002937)1.89231359
143Premature graying of hair (HP:0002216)1.88506152
144Premature ovarian failure (HP:0008209)1.88149647
145Vertebral fusion (HP:0002948)1.88024992
146Abnormality of the umbilical cord (HP:0010881)1.87121350
147Increased nuchal translucency (HP:0010880)1.86055046
148Maternal diabetes (HP:0009800)1.85212262
149Megaloblastic anemia (HP:0001889)1.84550480
150Aqueductal stenosis (HP:0002410)1.83141551
151Generalized hypotonia (HP:0001290)1.82169444
152Short hallux (HP:0010109)1.81828180
153Symptomatic seizures (HP:0011145)1.80831271

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WEE14.57564355
2EPHA23.97380620
3BUB13.68661947
4CDC73.55593306
5NEK13.40585169
6TNIK3.29691449
7CDK123.07370384
8TTK3.00197583
9TSSK62.86828682
10PNCK2.81559333
11TRIM282.70549700
12VRK22.65270256
13SRPK12.41957166
14TAF12.40272807
15EIF2AK12.34225155
16NEK22.26146597
17RPS6KB22.14079712
18PASK2.08491565
19PLK12.04277210
20NUAK12.00996275
21AKT31.96929437
22PLK31.89040353
23BMPR1B1.84750441
24CDK71.83557963
25ATR1.63985910
26LATS21.63199256
27CHEK21.58547619
28TLK11.57854403
29ALK1.51240007
30BRD41.43351966
31AURKB1.43072726
32CHEK11.40882407
33MAP3K81.38804900
34FLT31.37868246
35EIF2AK31.35903020
36BRSK21.34850078
37MKNK11.33017359
38AURKA1.31072604
39VRK11.30706703
40CDK41.25962070
41TESK21.25467920
42MKNK21.20693402
43ACVR1B1.20607112
44DYRK31.20587066
45MET1.15061279
46NME11.12942564
47SCYL21.10770083
48STK38L1.09959287
49ATM1.08686162
50CDK21.04335722
51PLK41.04026004
52PAK41.02619930
53PBK1.00343215
54PDK21.00020572
55STK40.99684828
56NLK0.98164192
57TGFBR10.92558395
58PDK40.91632166
59PDK30.91632166
60PKN20.89663351
61CDK190.89528481
62ZAK0.88885039
63PRKCI0.88075229
64STK100.85799517
65CSNK2A20.83701447
66EEF2K0.82248911
67NME20.81456661
68ERBB40.79049666
69OXSR10.78197447
70CSNK1D0.77391693
71MELK0.76724992
72PIM10.76645832
73CSNK1G10.76532171
74PLK20.75713151
75CDK10.74584512
76CDK60.73565551
77CSNK1E0.72678267
78BRAF0.72253336
79CASK0.69736043
80MTOR0.69570290
81BRSK10.68384992
82TIE10.67847669
83MAPKAPK30.66812970
84SMG10.64649054
85GRK10.63238023
86BCKDK0.61904152
87CSNK2A10.61189588
88DYRK20.61052127
89PAK10.60600369
90PRKDC0.53841992
91MST40.52098270
92AKT20.50468738
93FGFR10.49309196
94MAP3K90.48465736
95WNK30.44390533
96FGFR20.43015430
97ICK0.42428501
98BCR0.41672342
99LATS10.41586085
100RPS6KA50.40231207
101ERBB30.40013548
102CSNK1G20.39084321
103STK240.37057807
104DMPK0.36941026
105MAPK140.36921551
106STK160.36713615
107RPS6KA40.36084426
108TESK10.35824007
109EIF2AK20.33789017
110GSK3B0.33673250
111MAP4K20.33644102
112MAPK10.31106311
113SIK30.30207526
114YES10.28922593
115PRKCG0.28538262
116MAP3K40.27322372
117AKT10.26461084
118STK30.25783902
119CSNK1G30.25306562
120MAPK100.24742127
121CDK30.23723745
122MAP3K100.23056260
123CLK10.22751756
124EGFR0.20627281
125NEK60.20221235
126DAPK10.19306975
127TEC0.18523142
128FGR0.18294082
129PAK20.17866308
130RPS6KA10.15561559
131BMX0.15431247

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034304.79773937
2DNA replication_Homo sapiens_hsa030304.55774964
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.22785480
4One carbon pool by folate_Homo sapiens_hsa006703.61958109
5RNA transport_Homo sapiens_hsa030133.50797723
6Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.28273855
7Spliceosome_Homo sapiens_hsa030403.28258162
8RNA polymerase_Homo sapiens_hsa030203.18661706
9Nucleotide excision repair_Homo sapiens_hsa034202.88653655
10Homologous recombination_Homo sapiens_hsa034402.82854479
11Ribosome_Homo sapiens_hsa030102.75573114
12Proteasome_Homo sapiens_hsa030502.64101951
13Base excision repair_Homo sapiens_hsa034102.58570928
14Cell cycle_Homo sapiens_hsa041102.50828294
15Fanconi anemia pathway_Homo sapiens_hsa034602.29326129
16Pyrimidine metabolism_Homo sapiens_hsa002402.18724269
17Non-homologous end-joining_Homo sapiens_hsa034502.16208628
18Protein export_Homo sapiens_hsa030601.90833970
19mRNA surveillance pathway_Homo sapiens_hsa030151.90731861
20Steroid biosynthesis_Homo sapiens_hsa001001.87252346
21RNA degradation_Homo sapiens_hsa030181.85906515
22Propanoate metabolism_Homo sapiens_hsa006401.85553513
23Basal transcription factors_Homo sapiens_hsa030221.82936850
24Biosynthesis of amino acids_Homo sapiens_hsa012301.52141135
25p53 signaling pathway_Homo sapiens_hsa041151.50842875
26Cyanoamino acid metabolism_Homo sapiens_hsa004601.42418454
27Systemic lupus erythematosus_Homo sapiens_hsa053221.34129200
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.33736795
292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.32586615
30Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.28364636
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.21566649
32Fatty acid elongation_Homo sapiens_hsa000621.18823075
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.18263023
34Selenocompound metabolism_Homo sapiens_hsa004501.14851576
35Purine metabolism_Homo sapiens_hsa002301.14648176
36Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.14155865
37Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.11318602
38Oocyte meiosis_Homo sapiens_hsa041141.08085292
39Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.07154304
40Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.01675063
41Parkinsons disease_Homo sapiens_hsa050120.98940332
42Epstein-Barr virus infection_Homo sapiens_hsa051690.98578163
43Vitamin digestion and absorption_Homo sapiens_hsa049770.97880407
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.93919809
45Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.92910138
46Viral carcinogenesis_Homo sapiens_hsa052030.91078769
47Carbon metabolism_Homo sapiens_hsa012000.89414995
48Drug metabolism - other enzymes_Homo sapiens_hsa009830.88056746
49Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.87502450
50Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.86966511
51Hippo signaling pathway_Homo sapiens_hsa043900.85150414
52Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.83032427
53Folate biosynthesis_Homo sapiens_hsa007900.80938969
54Basal cell carcinoma_Homo sapiens_hsa052170.80330748
55Oxidative phosphorylation_Homo sapiens_hsa001900.80074764
56Fructose and mannose metabolism_Homo sapiens_hsa000510.78359842
57Pentose phosphate pathway_Homo sapiens_hsa000300.72674024
58TGF-beta signaling pathway_Homo sapiens_hsa043500.71200518
59MicroRNAs in cancer_Homo sapiens_hsa052060.68892807
60Pentose and glucuronate interconversions_Homo sapiens_hsa000400.67671043
61Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.66222753
62Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.60427603
63Fatty acid metabolism_Homo sapiens_hsa012120.60307377
64Fatty acid degradation_Homo sapiens_hsa000710.59415357
65Thyroid cancer_Homo sapiens_hsa052160.58587957
66Antigen processing and presentation_Homo sapiens_hsa046120.57407651
67Glutathione metabolism_Homo sapiens_hsa004800.56359973
68Central carbon metabolism in cancer_Homo sapiens_hsa052300.54401323
69Alcoholism_Homo sapiens_hsa050340.52972613
70Hedgehog signaling pathway_Homo sapiens_hsa043400.51816478
71beta-Alanine metabolism_Homo sapiens_hsa004100.50996430
72HTLV-I infection_Homo sapiens_hsa051660.50439207
73Adherens junction_Homo sapiens_hsa045200.48689975
74Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.48286205
75Tight junction_Homo sapiens_hsa045300.47864498
76Nitrogen metabolism_Homo sapiens_hsa009100.45892444
77Notch signaling pathway_Homo sapiens_hsa043300.45813521
78Herpes simplex infection_Homo sapiens_hsa051680.44352721
79Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.44184855
80Retinol metabolism_Homo sapiens_hsa008300.43768022
81Phototransduction_Homo sapiens_hsa047440.43227049
82Caffeine metabolism_Homo sapiens_hsa002320.42975291
83Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.42032787
84Peroxisome_Homo sapiens_hsa041460.41937432
85Butanoate metabolism_Homo sapiens_hsa006500.41335514
86Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.40421562
87Tryptophan metabolism_Homo sapiens_hsa003800.38549447
88Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.36726695
89Huntingtons disease_Homo sapiens_hsa050160.36545431
90Arginine and proline metabolism_Homo sapiens_hsa003300.36361430
91Alzheimers disease_Homo sapiens_hsa050100.35062836
92mTOR signaling pathway_Homo sapiens_hsa041500.34311948
93HIF-1 signaling pathway_Homo sapiens_hsa040660.32190243
94Colorectal cancer_Homo sapiens_hsa052100.32142027
95Vitamin B6 metabolism_Homo sapiens_hsa007500.31332134
96Bladder cancer_Homo sapiens_hsa052190.30749681
97Melanoma_Homo sapiens_hsa052180.30218407
98Galactose metabolism_Homo sapiens_hsa000520.29578760
99Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.29016882
100Pathways in cancer_Homo sapiens_hsa052000.27119668
101Fat digestion and absorption_Homo sapiens_hsa049750.26882985
102N-Glycan biosynthesis_Homo sapiens_hsa005100.23852302
103Small cell lung cancer_Homo sapiens_hsa052220.23786613
104Wnt signaling pathway_Homo sapiens_hsa043100.23304987
105Transcriptional misregulation in cancer_Homo sapiens_hsa052020.23080988
106Starch and sucrose metabolism_Homo sapiens_hsa005000.22119379
107Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.18864089
108Lysine degradation_Homo sapiens_hsa003100.17781460
109Legionellosis_Homo sapiens_hsa051340.17500250
110Metabolic pathways_Homo sapiens_hsa011000.17268720
111Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.17083787
112Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.16151234
113Pyruvate metabolism_Homo sapiens_hsa006200.14709825
114Arginine biosynthesis_Homo sapiens_hsa002200.14514081
115Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.14281786
116Primary bile acid biosynthesis_Homo sapiens_hsa001200.12088603
117Ether lipid metabolism_Homo sapiens_hsa005650.11293992
118Nicotine addiction_Homo sapiens_hsa050330.09747071
119Apoptosis_Homo sapiens_hsa042100.08650382
120PI3K-Akt signaling pathway_Homo sapiens_hsa041510.06851183
121Linoleic acid metabolism_Homo sapiens_hsa005910.06578493
122Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.05297690
123Thyroid hormone signaling pathway_Homo sapiens_hsa049190.05267903
124Prostate cancer_Homo sapiens_hsa052150.04247616
125Sulfur relay system_Homo sapiens_hsa041220.03939985
126Phenylalanine metabolism_Homo sapiens_hsa003600.03809027
127Regulation of actin cytoskeleton_Homo sapiens_hsa048100.01604772
128Renin-angiotensin system_Homo sapiens_hsa046140.00134662
129Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0235450
130Tyrosine metabolism_Homo sapiens_hsa00350-0.0222680
131Terpenoid backbone biosynthesis_Homo sapiens_hsa00900-0.0220527
132Bacterial invasion of epithelial cells_Homo sapiens_hsa05100-0.0212428
133Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563-0.0184472

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