TDGF1P3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The TDGF3 locus has characteristics of a retrotransposon, including lack of introns and a poly(A) sequence. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chromatin remodeling at centromere (GO:0031055)5.06842852
2CENP-A containing nucleosome assembly (GO:0034080)4.81398570
3DNA double-strand break processing (GO:0000729)4.72116807
4negative regulation of DNA-dependent DNA replication (GO:2000104)4.47897755
5histone exchange (GO:0043486)4.41389792
6regulation of mitotic spindle checkpoint (GO:1903504)4.26535900
7regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)4.26535900
8DNA replication checkpoint (GO:0000076)4.23341316
9regulation of nuclear cell cycle DNA replication (GO:0033262)4.21774816
10proteasome assembly (GO:0043248)4.17857260
11protein neddylation (GO:0045116)3.98162856
12establishment of protein localization to mitochondrial membrane (GO:0090151)3.87335118
13water-soluble vitamin biosynthetic process (GO:0042364)3.82892443
14DNA replication-independent nucleosome organization (GO:0034724)3.81980957
15DNA replication-independent nucleosome assembly (GO:0006336)3.81980957
16DNA replication-dependent nucleosome assembly (GO:0006335)3.76894982
17DNA replication-dependent nucleosome organization (GO:0034723)3.76894982
18purine nucleobase biosynthetic process (GO:0009113)3.72956485
19IMP biosynthetic process (GO:0006188)3.71798230
20somatic hypermutation of immunoglobulin genes (GO:0016446)3.70678287
21somatic diversification of immune receptors via somatic mutation (GO:0002566)3.70678287
22transcription elongation from RNA polymerase III promoter (GO:0006385)3.69938429
23termination of RNA polymerase III transcription (GO:0006386)3.69938429
24chaperone-mediated protein transport (GO:0072321)3.63498628
25DNA damage response, detection of DNA damage (GO:0042769)3.63117467
26exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.59263402
27establishment of integrated proviral latency (GO:0075713)3.56478306
28nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.54013219
29regulation of mesoderm development (GO:2000380)3.52747352
30regulation of helicase activity (GO:0051095)3.52293356
31nucleobase biosynthetic process (GO:0046112)3.49310852
32somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.41732676
33somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.41732676
34isotype switching (GO:0045190)3.41732676
35replication fork processing (GO:0031297)3.38326939
36anterior/posterior axis specification, embryo (GO:0008595)3.37969892
37negative regulation of DNA recombination (GO:0045910)3.36774515
38DNA catabolic process, exonucleolytic (GO:0000738)3.35187639
39RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.31812991
40pseudouridine synthesis (GO:0001522)3.28983963
41negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.28651860
42telomere maintenance via telomerase (GO:0007004)3.28415444
43cullin deneddylation (GO:0010388)3.26019021
44respiratory chain complex IV assembly (GO:0008535)3.24738677
45rRNA modification (GO:0000154)3.23409757
46IMP metabolic process (GO:0046040)3.22872987
47DNA deamination (GO:0045006)3.22635432
48mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.15672786
49histone mRNA metabolic process (GO:0008334)3.13475751
50regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.13423932
51L-serine metabolic process (GO:0006563)3.12701105
52protein deneddylation (GO:0000338)3.11418715
53ribosome assembly (GO:0042255)3.03604949
54response to X-ray (GO:0010165)3.01095298
55negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.00275558
56negative regulation of translation, ncRNA-mediated (GO:0040033)3.00275558
57regulation of translation, ncRNA-mediated (GO:0045974)3.00275558
58female gonad development (GO:0008585)2.98791769
59negative regulation of sister chromatid segregation (GO:0033046)2.97641378
60negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.97641378
61negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.97641378
62negative regulation of mitotic sister chromatid segregation (GO:0033048)2.97641378
63negative regulation of mitotic sister chromatid separation (GO:2000816)2.97641378
64mitotic metaphase plate congression (GO:0007080)2.96429118
65rRNA methylation (GO:0031167)2.95250883
66negative regulation of telomere maintenance (GO:0032205)2.94326910
67negative regulation of ligase activity (GO:0051352)2.94161282
68negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.94161282
69negative regulation of telomerase activity (GO:0051974)2.92832216
70negative regulation of chromosome segregation (GO:0051985)2.90437187
71mitochondrial RNA metabolic process (GO:0000959)2.90363045
72mitochondrial respiratory chain complex assembly (GO:0033108)2.88950813
73ATP synthesis coupled proton transport (GO:0015986)2.87786206
74energy coupled proton transport, down electrochemical gradient (GO:0015985)2.87786206
75spindle checkpoint (GO:0031577)2.85116032
76maturation of 5.8S rRNA (GO:0000460)2.84796498
77mitotic spindle checkpoint (GO:0071174)2.84453635
78tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.83976323
79RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.83976323
80positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.82374387
81maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.81910078
82mitochondrial respiratory chain complex I assembly (GO:0032981)2.81461651
83NADH dehydrogenase complex assembly (GO:0010257)2.81461651
84mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.81461651
85DNA strand renaturation (GO:0000733)2.81078098
86mitotic G2/M transition checkpoint (GO:0044818)2.80662257
87peptidyl-histidine modification (GO:0018202)2.79343158
88protein localization to kinetochore (GO:0034501)2.79312807
89anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.78036354
90regulation of centriole replication (GO:0046599)2.77532244
91spliceosomal snRNP assembly (GO:0000387)2.76322478
92lysine metabolic process (GO:0006553)2.76095615
93lysine catabolic process (GO:0006554)2.76095615
94protein complex biogenesis (GO:0070271)2.75089270
95somatic recombination of immunoglobulin gene segments (GO:0016447)2.74506712
96synapsis (GO:0007129)2.72680689
97regulation of telomere maintenance via telomerase (GO:0032210)2.72157311
98recombinational repair (GO:0000725)2.72050527
99non-recombinational repair (GO:0000726)2.71832604
100double-strand break repair via nonhomologous end joining (GO:0006303)2.71832604

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.28181390
2E2F7_22180533_ChIP-Seq_HELA_Human3.90637349
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.55897098
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.33576464
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.33088734
6MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.11069279
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.03649195
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.83444624
9ZNF274_21170338_ChIP-Seq_K562_Hela2.74466940
10VDR_22108803_ChIP-Seq_LS180_Human2.67646916
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.62114203
12CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.47765233
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.36603046
14ELK1_19687146_ChIP-ChIP_HELA_Human2.31117318
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.25026510
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.20494845
17POU5F1_16153702_ChIP-ChIP_HESCs_Human2.20326044
18EWS_26573619_Chip-Seq_HEK293_Human2.18103918
19MYC_18555785_ChIP-Seq_MESCs_Mouse2.15997858
20JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.09183003
21ETS1_20019798_ChIP-Seq_JURKAT_Human2.07323665
22VDR_23849224_ChIP-Seq_CD4+_Human1.91439579
23FUS_26573619_Chip-Seq_HEK293_Human1.87565403
24PCGF2_27294783_Chip-Seq_ESCs_Mouse1.84094065
25P300_19829295_ChIP-Seq_ESCs_Human1.82080604
26FOXP3_21729870_ChIP-Seq_TREG_Human1.81153853
27FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.80622048
28NANOG_16153702_ChIP-ChIP_HESCs_Human1.79577406
29MYC_18940864_ChIP-ChIP_HL60_Human1.76345717
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.75756618
31MYC_19030024_ChIP-ChIP_MESCs_Mouse1.70128337
32NOTCH1_21737748_ChIP-Seq_TLL_Human1.69816626
33IGF1R_20145208_ChIP-Seq_DFB_Human1.68050876
34KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.63972325
35PADI4_21655091_ChIP-ChIP_MCF-7_Human1.62006740
36POU3F2_20337985_ChIP-ChIP_501MEL_Human1.61633199
37NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.59934891
38FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.59660269
39HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.55789477
40SOX2_16153702_ChIP-ChIP_HESCs_Human1.52251303
41KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.49162335
42KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.49162335
43KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.49162335
44ZFP57_27257070_Chip-Seq_ESCs_Mouse1.48788193
45PCGF2_27294783_Chip-Seq_NPCs_Mouse1.42258526
46GBX2_23144817_ChIP-Seq_PC3_Human1.41618842
47MYC_19079543_ChIP-ChIP_MESCs_Mouse1.41188810
48PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39013150
49TAF15_26573619_Chip-Seq_HEK293_Human1.38822271
50SRF_21415370_ChIP-Seq_HL-1_Mouse1.36141577
51CTBP2_25329375_ChIP-Seq_LNCAP_Human1.36020907
52GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.32905852
53MYC_18358816_ChIP-ChIP_MESCs_Mouse1.31592304
54YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.30732293
55CTBP1_25329375_ChIP-Seq_LNCAP_Human1.27602155
56E2F1_18555785_ChIP-Seq_MESCs_Mouse1.26407163
57POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.25111800
58MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.23650505
59FOXM1_23109430_ChIP-Seq_U2OS_Human1.21314082
60TTF2_22483619_ChIP-Seq_HELA_Human1.18779172
61EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.18740310
62TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17605143
63IRF1_19129219_ChIP-ChIP_H3396_Human1.16960188
64CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.16233009
65E2F1_21310950_ChIP-Seq_MCF-7_Human1.15292180
66MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.15156913
67ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.15120519
68NELFA_20434984_ChIP-Seq_ESCs_Mouse1.14343899
69EZH2_27294783_Chip-Seq_NPCs_Mouse1.14133834
70SUZ12_27294783_Chip-Seq_NPCs_Mouse1.13798022
71THAP11_20581084_ChIP-Seq_MESCs_Mouse1.12654356
72SOX2_18555785_ChIP-Seq_MESCs_Mouse1.12478322
73NFE2_27457419_Chip-Seq_LIVER_Mouse1.10269614
74HOXB4_20404135_ChIP-ChIP_EML_Mouse1.07531352
75DCP1A_22483619_ChIP-Seq_HELA_Human1.07006052
76NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.06845662
77PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.06509981
78SOX2_19829295_ChIP-Seq_ESCs_Human1.06456879
79NANOG_19829295_ChIP-Seq_ESCs_Human1.06456879
80SMAD3_21741376_ChIP-Seq_EPCs_Human1.05651657
81GABP_19822575_ChIP-Seq_HepG2_Human1.05197471
82MYCN_18555785_ChIP-Seq_MESCs_Mouse1.03528238
83BCAT_22108803_ChIP-Seq_LS180_Human1.02844759
84UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.01935310
85TP53_22573176_ChIP-Seq_HFKS_Human1.00634698
86SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.99269588
87CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.97846693
88TCF4_22108803_ChIP-Seq_LS180_Human0.96569437
89AR_21909140_ChIP-Seq_LNCAP_Human0.96386258
90IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.95165266
91CBP_20019798_ChIP-Seq_JUKART_Human0.95165266
92NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.94987997
93HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.94883726
94SMAD4_21741376_ChIP-Seq_EPCs_Human0.94504196
95AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.94013598
96TP63_19390658_ChIP-ChIP_HaCaT_Human0.91956013
97ER_23166858_ChIP-Seq_MCF-7_Human0.90904780
98FOXA1_27270436_Chip-Seq_PROSTATE_Human0.90849077
99FOXA1_25329375_ChIP-Seq_VCAP_Human0.90849077
100KLF5_20875108_ChIP-Seq_MESCs_Mouse0.90439455

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003890_abnormal_embryonic-extraembry3.94077401
2MP0008877_abnormal_DNA_methylation3.76122251
3MP0008058_abnormal_DNA_repair3.36604052
4MP0003941_abnormal_skin_development3.33949469
5MP0010094_abnormal_chromosome_stability3.17308441
6MP0002254_reproductive_system_inflammat3.05936212
7MP0003693_abnormal_embryo_hatching2.83859729
8MP0004957_abnormal_blastocyst_morpholog2.64547968
9MP0006292_abnormal_olfactory_placode2.62115389
10MP0002102_abnormal_ear_morphology2.49506091
11MP0004133_heterotaxia2.40854808
12MP0003787_abnormal_imprinting2.29332206
13MP0001188_hyperpigmentation2.27681465
14MP0003111_abnormal_nucleus_morphology2.27252797
15MP0003195_calcinosis2.16498856
16MP0002736_abnormal_nociception_after2.15142324
17MP0003119_abnormal_digestive_system2.14520853
18MP0003718_maternal_effect2.14176759
19MP0006072_abnormal_retinal_apoptosis2.05842128
20MP0001293_anophthalmia2.05693062
21MP0008932_abnormal_embryonic_tissue1.95889338
22MP0008007_abnormal_cellular_replicative1.94524089
23MP0008057_abnormal_DNA_replication1.90187129
24MP0003121_genomic_imprinting1.87657241
25MP0001529_abnormal_vocalization1.86516764
26MP0005499_abnormal_olfactory_system1.81258927
27MP0005394_taste/olfaction_phenotype1.81258927
28MP0001984_abnormal_olfaction1.74252280
29MP0003937_abnormal_limbs/digits/tail_de1.69991020
30MP0002938_white_spotting1.63696591
31MP0003567_abnormal_fetal_cardiomyocyte1.63533310
32MP0003077_abnormal_cell_cycle1.63430335
33MP0008789_abnormal_olfactory_epithelium1.60004049
34MP0003136_yellow_coat_color1.59515846
35MP0003786_premature_aging1.54022200
36MP0003011_delayed_dark_adaptation1.52184267
37MP0001485_abnormal_pinna_reflex1.48177182
38MP0006035_abnormal_mitochondrial_morpho1.44104124
39MP0001968_abnormal_touch/_nociception1.40781062
40MP0003283_abnormal_digestive_organ1.39177567
41MP0003122_maternal_imprinting1.36538894
42MP0005551_abnormal_eye_electrophysiolog1.33111909
43MP0005084_abnormal_gallbladder_morpholo1.29281515
44MP0002277_abnormal_respiratory_mucosa1.28243653
45MP0008872_abnormal_physiological_respon1.27063887
46MP0005253_abnormal_eye_physiology1.24940532
47MP0001286_abnormal_eye_development1.19499112
48MP0002751_abnormal_autonomic_nervous1.19203608
49MP0002084_abnormal_developmental_patter1.15478518
50MP0009697_abnormal_copulation1.14056750
51MP0006036_abnormal_mitochondrial_physio1.09970602
52MP0008995_early_reproductive_senescence1.05469543
53MP0003123_paternal_imprinting1.03703220
54MP0000049_abnormal_middle_ear1.03262220
55MP0009672_abnormal_birth_weight1.01504969
56MP0003186_abnormal_redox_activity1.01231934
57MP0002085_abnormal_embryonic_tissue1.00825405
58MP0003806_abnormal_nucleotide_metabolis1.00667964
59MP0004215_abnormal_myocardial_fiber0.98500930
60MP0002233_abnormal_nose_morphology0.98413947
61MP0002210_abnormal_sex_determination0.97092306
62MP0001177_atelectasis0.96772260
63MP0000372_irregular_coat_pigmentation0.95575886
64MP0002111_abnormal_tail_morphology0.95506485
65MP0001730_embryonic_growth_arrest0.95337581
66MP0001929_abnormal_gametogenesis0.95023925
67MP0003880_abnormal_central_pattern0.94496560
68MP0003137_abnormal_impulse_conducting0.93772901
69MP0000579_abnormal_nail_morphology0.92613028
70MP0004147_increased_porphyrin_level0.90553843
71MP0000647_abnormal_sebaceous_gland0.88585303
72MP0000631_abnormal_neuroendocrine_gland0.88317717
73MP0005380_embryogenesis_phenotype0.88016395
74MP0001672_abnormal_embryogenesis/_devel0.88016395
75MP0002837_dystrophic_cardiac_calcinosis0.87017545
76MP0000653_abnormal_sex_gland0.86726712
77MP0001145_abnormal_male_reproductive0.86124359
78MP0005075_abnormal_melanosome_morpholog0.82863459
79MP0001697_abnormal_embryo_size0.82377434
80MP0003646_muscle_fatigue0.80641606
81MP0009703_decreased_birth_body0.79157901
82MP0005391_vision/eye_phenotype0.77876294
83MP0006276_abnormal_autonomic_nervous0.77239316
84MP0001119_abnormal_female_reproductive0.75781244
85MP0000350_abnormal_cell_proliferation0.74932966
86MP0004885_abnormal_endolymph0.71741959
87MP0002735_abnormal_chemical_nociception0.71524860
88MP0002090_abnormal_vision0.70020829
89MP0003698_abnormal_male_reproductive0.69827417
90MP0001324_abnormal_eye_pigmentation0.69337104
91MP0002734_abnormal_mechanical_nocicepti0.68725903
92MP0002272_abnormal_nervous_system0.67862920
93MP0001486_abnormal_startle_reflex0.65901376
94MP0002160_abnormal_reproductive_system0.65875485
95MP0004145_abnormal_muscle_electrophysio0.65692632
96MP0005195_abnormal_posterior_eye0.64555511
97MP0005395_other_phenotype0.63551420
98MP0009745_abnormal_behavioral_response0.62992175
99MP0005389_reproductive_system_phenotype0.62983081
100MP0005645_abnormal_hypothalamus_physiol0.62958154

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the labia minora (HP:0012880)4.42679765
2Colon cancer (HP:0003003)3.96898271
3Methylmalonic acidemia (HP:0002912)3.06971668
4Septo-optic dysplasia (HP:0100842)3.04003980
5Acute necrotizing encephalopathy (HP:0006965)2.98283675
6Meckel diverticulum (HP:0002245)2.88958811
7Acute encephalopathy (HP:0006846)2.84086329
8Abnormality of the ileum (HP:0001549)2.81739529
9Aplasia/Hypoplasia of the uvula (HP:0010293)2.76786493
10Abnormality of chromosome stability (HP:0003220)2.76657066
11Methylmalonic aciduria (HP:0012120)2.74696514
12Pancreatic cysts (HP:0001737)2.69052712
13Abnormal lung lobation (HP:0002101)2.66102323
14Abolished electroretinogram (ERG) (HP:0000550)2.66059819
15Birth length less than 3rd percentile (HP:0003561)2.64677169
16Ependymoma (HP:0002888)2.64350413
17Abnormality of serum amino acid levels (HP:0003112)2.56825648
18Pancreatic fibrosis (HP:0100732)2.53492906
19Hyperglycinemia (HP:0002154)2.51291755
20Chromosomal breakage induced by crosslinking agents (HP:0003221)2.50033093
21Progressive macrocephaly (HP:0004481)2.48285579
22Abnormality of methionine metabolism (HP:0010901)2.48118795
23Mitochondrial inheritance (HP:0001427)2.47937653
24Increased CSF lactate (HP:0002490)2.46674053
25Abnormality of aspartate family amino acid metabolism (HP:0010899)2.46254325
26Increased hepatocellular lipid droplets (HP:0006565)2.46156332
27Pancreatic islet-cell hyperplasia (HP:0004510)2.45920960
28Abnormal mitochondria in muscle tissue (HP:0008316)2.43537736
29Abnormality of the preputium (HP:0100587)2.38419822
30Chromsome breakage (HP:0040012)2.36655253
31Abnormality of glycine metabolism (HP:0010895)2.36129144
32Abnormality of serine family amino acid metabolism (HP:0010894)2.36129144
33Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.33594406
34True hermaphroditism (HP:0010459)2.32045161
35Abnormality of midbrain morphology (HP:0002418)2.28726714
36Molar tooth sign on MRI (HP:0002419)2.28726714
37Lipid accumulation in hepatocytes (HP:0006561)2.25447395
38Supernumerary spleens (HP:0009799)2.25046986
39Intestinal atresia (HP:0011100)2.24839528
40Hyperglycinuria (HP:0003108)2.21501560
41Volvulus (HP:0002580)2.17713305
42Abnormality of homocysteine metabolism (HP:0010919)2.16155992
43Homocystinuria (HP:0002156)2.16155992
44Rhabdomyosarcoma (HP:0002859)2.15550795
45Bilateral microphthalmos (HP:0007633)2.15500595
46Pendular nystagmus (HP:0012043)2.12885455
47Duodenal stenosis (HP:0100867)2.12722728
48Small intestinal stenosis (HP:0012848)2.12722728
49Nephronophthisis (HP:0000090)2.10525187
50Progressive inability to walk (HP:0002505)2.10476997
51Abnormality of the duodenum (HP:0002246)2.08707408
52Abnormality of the pons (HP:0007361)2.08056671
53Embryonal renal neoplasm (HP:0011794)2.07844991
54Cerebral edema (HP:0002181)2.06588499
55Optic nerve hypoplasia (HP:0000609)2.05015240
56Sloping forehead (HP:0000340)2.02301679
57Hypoplastic pelvis (HP:0008839)2.02247232
58Nephroblastoma (Wilms tumor) (HP:0002667)2.02197171
59Abnormality of the vitamin B12 metabolism (HP:0004341)2.02088132
60Hypoplasia of the pons (HP:0012110)2.01744605
61Abnormal biliary tract physiology (HP:0012439)2.01608552
62Bile duct proliferation (HP:0001408)2.01608552
63Abnormality of alanine metabolism (HP:0010916)1.98899831
64Hyperalaninemia (HP:0003348)1.98899831
65Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.98899831
66Abnormal hair whorl (HP:0010721)1.98425462
67Gonadotropin excess (HP:0000837)1.97685060
68Neoplasm of the adrenal gland (HP:0100631)1.97537779
69Hepatocellular necrosis (HP:0001404)1.96918151
70Horseshoe kidney (HP:0000085)1.96177389
71Abnormality of vitamin B metabolism (HP:0004340)1.94958165
72Glioma (HP:0009733)1.91900402
73Multiple enchondromatosis (HP:0005701)1.91721394
74Absent septum pellucidum (HP:0001331)1.90617290
75Triphalangeal thumb (HP:0001199)1.89597341
76Congenital, generalized hypertrichosis (HP:0004540)1.88590011
77Increased serum lactate (HP:0002151)1.88478079
78Agnosia (HP:0010524)1.87733639
79Aplasia/Hypoplasia of the spleen (HP:0010451)1.87624955
80Hyperinsulinemic hypoglycemia (HP:0000825)1.87185421
81Hypoplastic female external genitalia (HP:0012815)1.84369711
82Absent radius (HP:0003974)1.83814867
83Renal Fanconi syndrome (HP:0001994)1.83061207
84Bifid tongue (HP:0010297)1.82265962
85Asplenia (HP:0001746)1.82043573
86Inability to walk (HP:0002540)1.80397228
87Clubbing of toes (HP:0100760)1.79588754
88Type I transferrin isoform profile (HP:0003642)1.79368246
89Labial hypoplasia (HP:0000066)1.79111863
90Absent forearm bone (HP:0003953)1.77972877
91Aplasia involving forearm bones (HP:0009822)1.77972877
92Congenital stationary night blindness (HP:0007642)1.77584465
93Genital tract atresia (HP:0001827)1.77299893
94Dandy-Walker malformation (HP:0001305)1.77023926
95Optic disc pallor (HP:0000543)1.76726977
96Abdominal situs inversus (HP:0003363)1.76008900
97Abnormality of abdominal situs (HP:0011620)1.76008900
98Anencephaly (HP:0002323)1.74143884
99Vaginal atresia (HP:0000148)1.73948229
100Megaloblastic anemia (HP:0001889)1.73860677

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MKNK23.41784297
2TNIK3.10165387
3BUB13.08660229
4WNK33.06845974
5TSSK63.05905342
6NUAK12.87492834
7ACVR1B2.84401673
8TRIM282.83042910
9MST42.80361340
10ZAK2.70310873
11BMPR1B2.69257478
12CDC72.61971093
13VRK22.60900894
14MKNK12.49326803
15PLK32.42428336
16PLK42.27765359
17TTK2.27388196
18PBK2.11458686
19SRPK12.08352162
20TAF12.05319652
21VRK11.80041568
22EIF2AK31.73664704
23NEK11.62143667
24FRK1.60322896
25BRSK21.53391429
26GRK11.50017927
27MAP4K21.48472190
28WEE11.46964058
29PLK11.34054177
30ADRBK21.31826946
31OXSR11.29836462
32CASK1.22154363
33NME11.19007436
34DYRK21.16220424
35EIF2AK11.15942387
36TGFBR11.15211098
37STK161.10983821
38CSNK1G11.10763811
39TIE11.06992774
40NLK0.98451888
41PASK0.96535998
42EIF2AK20.95248509
43ERBB30.94501325
44BCR0.92668437
45PNCK0.92244297
46PLK20.89546788
47STK38L0.85383363
48PINK10.83953693
49CDK190.83002935
50ALK0.82729959
51ERBB40.82581932
52ATR0.80856067
53CSNK1G20.74733345
54TLK10.71353421
55BCKDK0.71315252
56INSRR0.69085800
57MAP3K40.67236722
58CHEK20.66598853
59STK30.65872470
60CSNK1G30.65595838
61DYRK30.65432462
62PRKCG0.62178512
63WNK40.61307821
64ATM0.60790661
65BRSK10.57898810
66MAPK130.56537475
67AURKB0.53853284
68STK390.53711320
69FLT30.50720046
70FGFR10.46880032
71CDK30.46354260
72CSNK1A1L0.45390150
73PRKCE0.44006178
74TEC0.43514799
75CSNK2A10.42616072
76CSNK1E0.41676064
77STK40.40647926
78CHEK10.40569855
79NEK20.40428807
80TXK0.40208517
81ADRBK10.37813575
82PRKDC0.33676090
83CSNK2A20.32849526
84CSNK1A10.32537896
85DAPK10.31696182
86FGFR20.27167535
87PAK30.27083290
88PRKCI0.26661303
89SIK30.26470931
90CDK10.26244137
91STK100.25854871
92MUSK0.24735693
93MINK10.24246145
94MELK0.23428356
95CAMK2A0.21581291
96DAPK20.21355073
97PRKCQ0.19607345
98PDK20.18152356
99CDK20.18120937
100PRKG10.17086918

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.75999790
2Mismatch repair_Homo sapiens_hsa034302.94924210
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.86011075
4RNA polymerase_Homo sapiens_hsa030202.81137308
5Protein export_Homo sapiens_hsa030602.76676043
6Homologous recombination_Homo sapiens_hsa034402.68368504
7Non-homologous end-joining_Homo sapiens_hsa034502.63429047
8DNA replication_Homo sapiens_hsa030302.30200243
9One carbon pool by folate_Homo sapiens_hsa006702.27966569
10Basal transcription factors_Homo sapiens_hsa030222.20480893
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.19164379
12Propanoate metabolism_Homo sapiens_hsa006402.16004833
13Oxidative phosphorylation_Homo sapiens_hsa001902.13543317
14Fanconi anemia pathway_Homo sapiens_hsa034602.06294726
15RNA degradation_Homo sapiens_hsa030181.99566096
16Steroid biosynthesis_Homo sapiens_hsa001001.95062442
17Parkinsons disease_Homo sapiens_hsa050121.93775563
18RNA transport_Homo sapiens_hsa030131.93740260
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.87743678
20Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.79543336
21Cysteine and methionine metabolism_Homo sapiens_hsa002701.77186317
22Selenocompound metabolism_Homo sapiens_hsa004501.66388833
23Vitamin B6 metabolism_Homo sapiens_hsa007501.63972688
24Spliceosome_Homo sapiens_hsa030401.63827748
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.61928675
26Base excision repair_Homo sapiens_hsa034101.58604205
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.56385529
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.55294938
29Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.53770140
30Ribosome_Homo sapiens_hsa030101.49131299
31Nucleotide excision repair_Homo sapiens_hsa034201.38656413
32Phototransduction_Homo sapiens_hsa047441.38389055
33Pyruvate metabolism_Homo sapiens_hsa006201.36985469
34Huntingtons disease_Homo sapiens_hsa050161.36859151
35Butanoate metabolism_Homo sapiens_hsa006501.31837908
36Pyrimidine metabolism_Homo sapiens_hsa002401.26309301
37Purine metabolism_Homo sapiens_hsa002301.24539075
38Fatty acid elongation_Homo sapiens_hsa000621.22836592
39Cell cycle_Homo sapiens_hsa041101.22554982
402-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.21147648
41Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.17961488
42Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.12667048
43Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.11399093
44Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.04935517
45Alzheimers disease_Homo sapiens_hsa050101.04832032
46Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.99407342
47Vitamin digestion and absorption_Homo sapiens_hsa049770.97378737
48Tryptophan metabolism_Homo sapiens_hsa003800.92086658
49Caffeine metabolism_Homo sapiens_hsa002320.90473169
50Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.83211090
51Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.83161744
52Nicotine addiction_Homo sapiens_hsa050330.82267129
53Linoleic acid metabolism_Homo sapiens_hsa005910.81898788
54Peroxisome_Homo sapiens_hsa041460.81686833
55alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.80887066
56Glutathione metabolism_Homo sapiens_hsa004800.79601688
57mRNA surveillance pathway_Homo sapiens_hsa030150.77765224
58Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.76183516
59Retinol metabolism_Homo sapiens_hsa008300.74086660
60Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.74039008
61Metabolic pathways_Homo sapiens_hsa011000.73248867
62Nitrogen metabolism_Homo sapiens_hsa009100.72774167
63Pentose and glucuronate interconversions_Homo sapiens_hsa000400.69825803
64beta-Alanine metabolism_Homo sapiens_hsa004100.68898947
65Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.66580722
66Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.65356140
67Fatty acid degradation_Homo sapiens_hsa000710.64331456
68Ether lipid metabolism_Homo sapiens_hsa005650.64106079
69Fatty acid metabolism_Homo sapiens_hsa012120.64095396
70p53 signaling pathway_Homo sapiens_hsa041150.62372377
71Oocyte meiosis_Homo sapiens_hsa041140.61986174
72Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.61563866
73Biosynthesis of amino acids_Homo sapiens_hsa012300.58905426
74Primary bile acid biosynthesis_Homo sapiens_hsa001200.56806230
75Carbon metabolism_Homo sapiens_hsa012000.55161761
76Maturity onset diabetes of the young_Homo sapiens_hsa049500.54475676
77Cardiac muscle contraction_Homo sapiens_hsa042600.53259777
78Basal cell carcinoma_Homo sapiens_hsa052170.52860226
79Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.50899932
80Chemical carcinogenesis_Homo sapiens_hsa052040.50252781
81Wnt signaling pathway_Homo sapiens_hsa043100.50107075
82Hedgehog signaling pathway_Homo sapiens_hsa043400.49743552
83Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.49529249
84Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48921671
85Fat digestion and absorption_Homo sapiens_hsa049750.48178600
86Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.45508919
87Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.45344005
88Arginine and proline metabolism_Homo sapiens_hsa003300.42103111
89TGF-beta signaling pathway_Homo sapiens_hsa043500.41414506
90Olfactory transduction_Homo sapiens_hsa047400.41049305
91Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.38693214
92Folate biosynthesis_Homo sapiens_hsa007900.38642706
93Taste transduction_Homo sapiens_hsa047420.37959399
94Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.37280492
95Hippo signaling pathway_Homo sapiens_hsa043900.32830203
96Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.31832766
97Sulfur metabolism_Homo sapiens_hsa009200.31096045
98Steroid hormone biosynthesis_Homo sapiens_hsa001400.30243866
99Arachidonic acid metabolism_Homo sapiens_hsa005900.28418220
100Collecting duct acid secretion_Homo sapiens_hsa049660.26214909

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