TDGF1P7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)6.08553998
2peptidyl-histidine modification (GO:0018202)5.25857936
3maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)4.96849922
4negative regulation of DNA-dependent DNA replication (GO:2000104)4.81007655
5negative regulation of cell cycle arrest (GO:0071157)4.48093465
6chaperone-mediated protein transport (GO:0072321)4.45994862
7protein neddylation (GO:0045116)4.19875730
8protein deneddylation (GO:0000338)4.02778772
9base-excision repair, AP site formation (GO:0006285)3.84591395
10mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.79190568
11establishment of protein localization to mitochondrial membrane (GO:0090151)3.71063086
12cotranslational protein targeting to membrane (GO:0006613)3.70814522
13SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.68599254
14spinal cord motor neuron differentiation (GO:0021522)3.68381021
15ribosomal small subunit assembly (GO:0000028)3.65360135
16protein targeting to ER (GO:0045047)3.59506627
17intraciliary transport (GO:0042073)3.58006875
18chondrocyte proliferation (GO:0035988)3.56983480
19mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.56824605
20mitochondrial respiratory chain complex I assembly (GO:0032981)3.56824605
21NADH dehydrogenase complex assembly (GO:0010257)3.56824605
22ATP synthesis coupled proton transport (GO:0015986)3.52111720
23energy coupled proton transport, down electrochemical gradient (GO:0015985)3.52111720
24regulation of helicase activity (GO:0051095)3.50737355
25cullin deneddylation (GO:0010388)3.48397187
26viral transcription (GO:0019083)3.45224077
27protein localization to endoplasmic reticulum (GO:0070972)3.43391905
28establishment of protein localization to endoplasmic reticulum (GO:0072599)3.43254238
29DNA damage response, detection of DNA damage (GO:0042769)3.42674307
30translational termination (GO:0006415)3.38266836
31growth hormone secretion (GO:0030252)3.35936035
32cell differentiation in spinal cord (GO:0021515)3.35626990
33activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO3.30809371
34IMP biosynthetic process (GO:0006188)3.28533856
35protein complex biogenesis (GO:0070271)3.24903737
36epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.17393578
37IMP metabolic process (GO:0046040)3.15663013
38mitochondrial respiratory chain complex assembly (GO:0033108)3.15541946
39neuron projection extension involved in neuron projection guidance (GO:1902284)3.14898937
40axon extension involved in axon guidance (GO:0048846)3.14898937
41skeletal muscle tissue regeneration (GO:0043403)3.08924428
42mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.06094168
43oxidative phosphorylation (GO:0006119)3.04322220
44dorsal/ventral neural tube patterning (GO:0021904)2.99166370
45DNA strand renaturation (GO:0000733)2.98034420
46G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.94161723
47translational elongation (GO:0006414)2.91073226
48pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.89060397
49mitochondrial RNA metabolic process (GO:0000959)2.88996156
50translational initiation (GO:0006413)2.88686771
51epithelial cilium movement (GO:0003351)2.85743151
52transcription elongation from RNA polymerase II promoter (GO:0006368)2.85307076
53nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.83270044
54transcription elongation from RNA polymerase III promoter (GO:0006385)2.81844013
55termination of RNA polymerase III transcription (GO:0006386)2.81844013
56somatic hypermutation of immunoglobulin genes (GO:0016446)2.81796319
57somatic diversification of immune receptors via somatic mutation (GO:0002566)2.81796319
58protein targeting to membrane (GO:0006612)2.81039850
59protein localization to Golgi apparatus (GO:0034067)2.80757586
60nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.79737405
61nucleoside diphosphate phosphorylation (GO:0006165)2.78266103
62intracellular protein transmembrane import (GO:0044743)2.78187808
63respiratory electron transport chain (GO:0022904)2.76317725
64histone H4-K12 acetylation (GO:0043983)2.73951885
65negative regulation of oligodendrocyte differentiation (GO:0048715)2.73888645
66short-term memory (GO:0007614)2.72523067
67electron transport chain (GO:0022900)2.71248785
68translation (GO:0006412)2.70842691
69spinal cord association neuron differentiation (GO:0021527)2.70100295
70sulfate transmembrane transport (GO:1902358)2.68024340
71protein polyglutamylation (GO:0018095)2.67484367
72localization within membrane (GO:0051668)2.67074695
73proteasome assembly (GO:0043248)2.65659447
74platelet dense granule organization (GO:0060155)2.65263682
75negative regulation of Notch signaling pathway (GO:0045746)2.64976187
76tRNA aminoacylation for protein translation (GO:0006418)2.62470346
77positive regulation of gastrulation (GO:2000543)2.60682588
78sperm motility (GO:0030317)2.60534696
79retinal ganglion cell axon guidance (GO:0031290)2.60113761
80metallo-sulfur cluster assembly (GO:0031163)2.58791722
81iron-sulfur cluster assembly (GO:0016226)2.58791722
82DNA-templated transcription, elongation (GO:0006354)2.58539257
83exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.57926152
84resolution of meiotic recombination intermediates (GO:0000712)2.56151251
85regulation of telomere maintenance via telomerase (GO:0032210)2.56125038
86tRNA modification (GO:0006400)2.55961556
87male meiosis (GO:0007140)2.55684069
88cellular protein complex disassembly (GO:0043624)2.55190645
89AMP metabolic process (GO:0046033)2.54763415
90protein insertion into membrane (GO:0051205)2.54168998
91calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.53819241
92regulation of non-canonical Wnt signaling pathway (GO:2000050)2.53664146
93regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.53523572
94regulation of mitotic spindle checkpoint (GO:1903504)2.53523572
95protein targeting to mitochondrion (GO:0006626)2.52485422
96retina layer formation (GO:0010842)2.52068364
97positive regulation of prostaglandin secretion (GO:0032308)2.51508630
98cell proliferation in forebrain (GO:0021846)2.50766493
99regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.49651158
100mismatch repair (GO:0006298)2.46921175

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.28900869
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.16310881
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.88127840
4HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.24566052
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.05513692
6ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.82387921
7EST1_17652178_ChIP-ChIP_JURKAT_Human2.81651079
8CREB1_15753290_ChIP-ChIP_HEK293T_Human2.79985504
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.63785544
10CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.63386849
11CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.53601936
12NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.50568045
13TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.18651734
14ZNF274_21170338_ChIP-Seq_K562_Hela2.13167894
15ELK1_19687146_ChIP-ChIP_HELA_Human2.10103868
16VDR_23849224_ChIP-Seq_CD4+_Human2.06033275
17MYC_18555785_ChIP-Seq_MESCs_Mouse2.03688082
18TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.02288819
19DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.01094629
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.99610791
21RBPJ_22232070_ChIP-Seq_NCS_Mouse1.96017141
22PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.91830434
23HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.90880452
24FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.87845265
25FOXP3_21729870_ChIP-Seq_TREG_Human1.86174711
26MYC_18358816_ChIP-ChIP_MESCs_Mouse1.81712246
27GBX2_23144817_ChIP-Seq_PC3_Human1.79851371
28GABP_19822575_ChIP-Seq_HepG2_Human1.71728195
29XRN2_22483619_ChIP-Seq_HELA_Human1.70216754
30SOX2_16153702_ChIP-ChIP_HESCs_Human1.69762157
31ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.68286753
32SOX2_18555785_ChIP-Seq_MESCs_Mouse1.62417140
33THAP11_20581084_ChIP-Seq_MESCs_Mouse1.59160364
34BP1_19119308_ChIP-ChIP_Hs578T_Human1.57657783
35POU5F1_16153702_ChIP-ChIP_HESCs_Human1.56935562
36E2F1_18555785_ChIP-Seq_MESCs_Mouse1.55514074
37NANOG_16153702_ChIP-ChIP_HESCs_Human1.54482506
38TTF2_22483619_ChIP-Seq_HELA_Human1.54295097
39YY1_21170310_ChIP-Seq_MESCs_Mouse1.52912295
40EZH2_22144423_ChIP-Seq_EOC_Human1.52729111
41TP63_19390658_ChIP-ChIP_HaCaT_Human1.52579581
42HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.49313371
43SRF_21415370_ChIP-Seq_HL-1_Mouse1.46305609
44FUS_26573619_Chip-Seq_HEK293_Human1.43258011
45MYC_19030024_ChIP-ChIP_MESCs_Mouse1.37533266
46MYC_19079543_ChIP-ChIP_MESCs_Mouse1.37351825
47IRF1_19129219_ChIP-ChIP_H3396_Human1.37026806
48HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.36846354
49MYC_18940864_ChIP-ChIP_HL60_Human1.36583351
50IKZF1_21737484_ChIP-ChIP_HCT116_Human1.36188169
51DCP1A_22483619_ChIP-Seq_HELA_Human1.35317626
52SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.30461735
53SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.30001173
54MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.29990036
55EWS_26573619_Chip-Seq_HEK293_Human1.29575917
56CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.29551353
57VDR_22108803_ChIP-Seq_LS180_Human1.26494183
58FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.22578059
59SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.22576097
60POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.21312240
61ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.19641336
62MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.18602266
63CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.18004313
64TP53_22573176_ChIP-Seq_HFKS_Human1.17114928
65ERG_21242973_ChIP-ChIP_JURKAT_Human1.15640146
66CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.14674957
67BMI1_23680149_ChIP-Seq_NPCS_Mouse1.13974988
68ELK1_22589737_ChIP-Seq_MCF10A_Human1.11832441
69GATA1_26923725_Chip-Seq_HPCs_Mouse1.10088503
70NELFA_20434984_ChIP-Seq_ESCs_Mouse1.09946832
71BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.08686940
72KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.08319751
73IGF1R_20145208_ChIP-Seq_DFB_Human1.03856334
74EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.02480962
75CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.01778899
76ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.01038167
77MYCN_18555785_ChIP-Seq_MESCs_Mouse0.98758257
78EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.98292364
79P300_19829295_ChIP-Seq_ESCs_Human0.97362695
80FLI1_27457419_Chip-Seq_LIVER_Mouse0.95645961
81SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.93764653
82PADI4_21655091_ChIP-ChIP_MCF-7_Human0.92709035
83POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.92052059
84TAF15_26573619_Chip-Seq_HEK293_Human0.91369068
85PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.89747488
86FOXP1_21924763_ChIP-Seq_HESCs_Human0.89262548
87CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.88635655
88SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.88233015
89ZFX_18555785_ChIP-Seq_MESCs_Mouse0.87917626
90PCGF2_27294783_Chip-Seq_NPCs_Mouse0.86847029
91EZH2_27304074_Chip-Seq_ESCs_Mouse0.86724115
92GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.84300175
93SRY_22984422_ChIP-ChIP_TESTIS_Rat0.83379689
94ZFP57_27257070_Chip-Seq_ESCs_Mouse0.83320576
95E2F4_17652178_ChIP-ChIP_JURKAT_Human0.82971804
96PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.81580329
97TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.80859014
98YY1_22570637_ChIP-Seq_MALME-3M_Human0.80416036
99REST_18959480_ChIP-ChIP_MESCs_Mouse0.79032696
100RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.77556302

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002102_abnormal_ear_morphology4.48206697
2MP0002163_abnormal_gland_morphology3.90044731
3MP0006072_abnormal_retinal_apoptosis3.82308315
4MP0010030_abnormal_orbit_morphology3.60614641
5MP0003122_maternal_imprinting3.11514252
6MP0005645_abnormal_hypothalamus_physiol3.06125471
7MP0006292_abnormal_olfactory_placode3.05011347
8MP0001529_abnormal_vocalization2.86133181
9MP0005394_taste/olfaction_phenotype2.71992744
10MP0005499_abnormal_olfactory_system2.71992744
11MP0003880_abnormal_central_pattern2.56389815
12MP0008789_abnormal_olfactory_epithelium2.55489818
13MP0005379_endocrine/exocrine_gland_phen2.53670560
14MP0005253_abnormal_eye_physiology2.41279534
15MP0006276_abnormal_autonomic_nervous2.37197743
16MP0003011_delayed_dark_adaptation2.15664317
17MP0002822_catalepsy2.15326298
18MP0000049_abnormal_middle_ear2.05332255
19MP0000778_abnormal_nervous_system1.93491454
20MP0004133_heterotaxia1.91208934
21MP0002653_abnormal_ependyma_morphology1.86398809
22MP0002938_white_spotting1.78181319
23MP0003121_genomic_imprinting1.72918779
24MP0000750_abnormal_muscle_regeneration1.62911629
25MP0002282_abnormal_trachea_morphology1.60405110
26MP0006054_spinal_hemorrhage1.58944917
27MP0002638_abnormal_pupillary_reflex1.57915620
28MP0009046_muscle_twitch1.53113473
29MP0003890_abnormal_embryonic-extraembry1.50473958
30MP0003787_abnormal_imprinting1.44758472
31MP0000569_abnormal_digit_pigmentation1.44017968
32MP0005551_abnormal_eye_electrophysiolog1.43698613
33MP0008058_abnormal_DNA_repair1.40172606
34MP0001293_anophthalmia1.33939066
35MP0003937_abnormal_limbs/digits/tail_de1.32281145
36MP0005391_vision/eye_phenotype1.30780947
37MP0002752_abnormal_somatic_nervous1.28346515
38MP0001984_abnormal_olfaction1.24485862
39MP0005377_hearing/vestibular/ear_phenot1.23933780
40MP0003878_abnormal_ear_physiology1.23933780
41MP0008877_abnormal_DNA_methylation1.22563937
42MP0002557_abnormal_social/conspecific_i1.19755233
43MP0000631_abnormal_neuroendocrine_gland1.19394214
44MP0002928_abnormal_bile_duct1.18749124
45MP0003567_abnormal_fetal_cardiomyocyte1.17560294
46MP0003718_maternal_effect1.16937148
47MP0002233_abnormal_nose_morphology1.16259498
48MP0000955_abnormal_spinal_cord1.15599031
49MP0001986_abnormal_taste_sensitivity1.14709664
50MP0002751_abnormal_autonomic_nervous1.12656811
51MP0002736_abnormal_nociception_after1.12556355
52MP0005423_abnormal_somatic_nervous1.11188960
53MP0008875_abnormal_xenobiotic_pharmacok1.10710190
54MP0002160_abnormal_reproductive_system1.07049956
55MP0008569_lethality_at_weaning1.06594348
56MP0000026_abnormal_inner_ear1.03849292
57MP0002111_abnormal_tail_morphology1.01911527
58MP0005195_abnormal_posterior_eye1.00430815
59MP0001324_abnormal_eye_pigmentation1.00393617
60MP0002735_abnormal_chemical_nociception0.99812591
61MP0002184_abnormal_innervation0.99141954
62MP0004924_abnormal_behavior0.96733598
63MP0005386_behavior/neurological_phenoty0.96733598
64MP0008260_abnormal_autophagy0.96142245
65MP0005084_abnormal_gallbladder_morpholo0.94985639
66MP0004957_abnormal_blastocyst_morpholog0.92578226
67MP0002090_abnormal_vision0.90151156
68MP0009379_abnormal_foot_pigmentation0.90083027
69MP0001485_abnormal_pinna_reflex0.89403800
70MP0001756_abnormal_urination0.88782976
71MP0002734_abnormal_mechanical_nocicepti0.87821106
72MP0006036_abnormal_mitochondrial_physio0.87126489
73MP0003186_abnormal_redox_activity0.86992855
74MP0002882_abnormal_neuron_morphology0.83952459
75MP0004811_abnormal_neuron_physiology0.82388758
76MP0001968_abnormal_touch/_nociception0.81804041
77MP0004270_analgesia0.81012668
78MP0003861_abnormal_nervous_system0.80924169
79MP0001286_abnormal_eye_development0.79914952
80MP0002210_abnormal_sex_determination0.79647281
81MP0003755_abnormal_palate_morphology0.78121606
82MP0008932_abnormal_embryonic_tissue0.77221824
83MP0002116_abnormal_craniofacial_bone0.75685712
84MP0002234_abnormal_pharynx_morphology0.75087955
85MP0005174_abnormal_tail_pigmentation0.74585201
86MP0002272_abnormal_nervous_system0.74004695
87MP0001905_abnormal_dopamine_level0.73087954
88MP0006035_abnormal_mitochondrial_morpho0.70382838
89MP0003385_abnormal_body_wall0.69983109
90MP0005085_abnormal_gallbladder_physiolo0.68699520
91MP0003635_abnormal_synaptic_transmissio0.68522260
92MP0000358_abnormal_cell_content/0.67781621
93MP0003806_abnormal_nucleotide_metabolis0.67734558
94MP0002152_abnormal_brain_morphology0.67386907
95MP0002066_abnormal_motor_capabilities/c0.66914466
96MP0001963_abnormal_hearing_physiology0.65839973
97MP0003137_abnormal_impulse_conducting0.65677812
98MP0002084_abnormal_developmental_patter0.65206941
99MP0002063_abnormal_learning/memory/cond0.64783327
100MP0004134_abnormal_chest_morphology0.63900492

Predicted human phenotypes

RankGene SetZ-score
1Increased hepatocellular lipid droplets (HP:0006565)4.69593652
2Abnormality of midbrain morphology (HP:0002418)4.39118537
3Molar tooth sign on MRI (HP:0002419)4.39118537
4Colon cancer (HP:0003003)4.15755250
5Lipid accumulation in hepatocytes (HP:0006561)3.88622776
6Rhabdomyosarcoma (HP:0002859)3.60341133
7Renal Fanconi syndrome (HP:0001994)3.60093630
8Acute necrotizing encephalopathy (HP:0006965)3.51918252
9Occipital encephalocele (HP:0002085)3.50018059
10Mitochondrial inheritance (HP:0001427)3.48983420
11Rib fusion (HP:0000902)3.40515403
12Microvesicular hepatic steatosis (HP:0001414)3.38810413
13Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.32804840
14Acute encephalopathy (HP:0006846)3.22706512
15Polyphagia (HP:0002591)3.22621772
16Amelogenesis imperfecta (HP:0000705)3.21257616
17Long foot (HP:0001833)3.13622351
18Increased CSF lactate (HP:0002490)3.12391562
19Hyperglycinemia (HP:0002154)2.98853688
20Exertional dyspnea (HP:0002875)2.87985391
21Abnormal mitochondria in muscle tissue (HP:0008316)2.87404612
22True hermaphroditism (HP:0010459)2.85477793
23Nephronophthisis (HP:0000090)2.83415543
24Chronic hepatic failure (HP:0100626)2.82655023
25Nephrogenic diabetes insipidus (HP:0009806)2.76221265
26Medial flaring of the eyebrow (HP:0010747)2.73473197
27Cerebral hypomyelination (HP:0006808)2.71127352
28Hepatocellular necrosis (HP:0001404)2.69369129
29Progressive macrocephaly (HP:0004481)2.68433347
30Decreased activity of mitochondrial respiratory chain (HP:0008972)2.64735269
31Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.64735269
32Ependymoma (HP:0002888)2.63638131
33Hyperglycinuria (HP:0003108)2.62929567
34Increased intramyocellular lipid droplets (HP:0012240)2.60788845
35Congenital primary aphakia (HP:0007707)2.58008245
36Retinal dysplasia (HP:0007973)2.57328570
37Thyroid-stimulating hormone excess (HP:0002925)2.57305821
38Neoplasm of striated muscle (HP:0009728)2.54377036
39Tubular atrophy (HP:0000092)2.53954591
40Supernumerary spleens (HP:0009799)2.53844112
41Increased serum lactate (HP:0002151)2.52994435
42Gait imbalance (HP:0002141)2.52824775
43Pancreatic cysts (HP:0001737)2.51650206
44Microretrognathia (HP:0000308)2.43494294
45Cerebral edema (HP:0002181)2.41431863
46Myokymia (HP:0002411)2.35065568
47Hepatic necrosis (HP:0002605)2.31722834
48Pancreatic fibrosis (HP:0100732)2.30009540
49Abnormality of glycine metabolism (HP:0010895)2.27918329
50Abnormality of serine family amino acid metabolism (HP:0010894)2.27918329
51Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.26265427
52Postaxial hand polydactyly (HP:0001162)2.24470079
53Upper limb muscle weakness (HP:0003484)2.23010661
54Respiratory difficulties (HP:0002880)2.20153191
55Agnosia (HP:0010524)2.19105658
56Abnormal biliary tract physiology (HP:0012439)2.18602534
57Bile duct proliferation (HP:0001408)2.18602534
58Abnormality of the astrocytes (HP:0100707)2.17327533
59Astrocytoma (HP:0009592)2.17327533
60Hyperphosphaturia (HP:0003109)2.16326876
61Postaxial foot polydactyly (HP:0001830)2.15964158
62Bifid tongue (HP:0010297)2.14399940
63Abnormality of renal resorption (HP:0011038)2.14340255
64Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.10935916
65Lactic acidosis (HP:0003128)2.04063205
66Exercise intolerance (HP:0003546)2.02567923
67Abnormality of urine glucose concentration (HP:0011016)2.00482544
68Glycosuria (HP:0003076)2.00482544
69Vaginal atresia (HP:0000148)1.99131153
70CNS hypomyelination (HP:0003429)1.97735055
71Abnormality of dental color (HP:0011073)1.96376847
72Septo-optic dysplasia (HP:0100842)1.96139201
73Broad foot (HP:0001769)1.95685912
74Epileptic encephalopathy (HP:0200134)1.93553162
75Pendular nystagmus (HP:0012043)1.91631904
76Abnormality of the renal medulla (HP:0100957)1.90396869
77Leukodystrophy (HP:0002415)1.87584738
78Cortical dysplasia (HP:0002539)1.87499676
79Optic disc pallor (HP:0000543)1.86554726
80Anencephaly (HP:0002323)1.85834554
81Abnormal ciliary motility (HP:0012262)1.85381235
82Genital tract atresia (HP:0001827)1.84996052
83Increased muscle lipid content (HP:0009058)1.84796676
84Abnormality of abdominal situs (HP:0011620)1.83255419
85Abdominal situs inversus (HP:0003363)1.83255419
86Narrow forehead (HP:0000341)1.79878815
87Inability to walk (HP:0002540)1.79769087
88Increased serum pyruvate (HP:0003542)1.77763534
89Exercise-induced muscle cramps (HP:0003710)1.77313758
90Glioma (HP:0009733)1.76880046
91Decreased muscle mass (HP:0003199)1.76126309
92Hand muscle atrophy (HP:0009130)1.75914356
93Anomalous pulmonary venous return (HP:0010772)1.74779236
94Failure to thrive in infancy (HP:0001531)1.73376094
95Poor coordination (HP:0002370)1.72274791
96Abnormality of serum amino acid levels (HP:0003112)1.72211837
97Generalized hypotonia (HP:0001290)1.70797293
98Reticulocytopenia (HP:0001896)1.70676275
99Oculomotor apraxia (HP:0000657)1.70188714
100Neonatal respiratory distress (HP:0002643)1.64378717

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K26.48338209
2CDK93.88557576
3BCKDK3.23812352
4STK163.18998454
5WNK32.98017036
6TRIM282.93300925
7EPHA42.43068379
8WNK12.39737960
9CDK192.38600245
10BMPR1B2.32976102
11MKNK12.26558334
12SRPK12.19845057
13NUAK12.05188442
14MKNK22.03930111
15MAPK152.01583788
16BCR1.96672959
17TNIK1.88838845
18DYRK31.66089888
19PBK1.58199987
20CSNK1G31.52235108
21CSNK1G11.45704049
22VRK21.43981832
23ZAK1.43659356
24EIF2AK31.37465970
25CSNK1A1L1.37179520
26TGFBR11.34696290
27ACVR1B1.32933843
28CASK1.32190530
29PLK41.31892593
30MAP3K41.31277531
31DYRK21.26564205
32CSNK1G21.23939354
33INSRR1.20070663
34GRK11.14626634
35PDK21.03554411
36OXSR11.02209937
37PLK20.99919512
38MAPK130.99696825
39TSSK60.96007187
40TLK10.95544069
41AKT20.95492292
42PLK30.93998048
43NME10.89274583
44TIE10.88440369
45NTRK20.88311069
46CDK80.83756755
47CDK30.77593759
48ADRBK20.76123730
49PLK10.72126810
50EPHB20.70025654
51DYRK1A0.68832978
52CAMK1D0.67567445
53TTK0.65410393
54CDK180.62530934
55MINK10.62406715
56CDK11A0.60232511
57CDK140.59264481
58ERBB40.58853925
59CDK150.57437897
60VRK10.54550285
61ILK0.53911860
62ATR0.52971868
63RPS6KA50.52712512
64EIF2AK10.51762854
65EPHA20.50486470
66CSNK1A10.48951692
67NEK20.48934050
68RPS6KA40.48010174
69MAP2K70.46726563
70PRKCG0.46034312
71PRKCE0.43954200
72CLK10.42129200
73KDR0.41794642
74LATS10.41705935
75AURKA0.41241054
76CAMK10.41196452
77ADRBK10.40857410
78DYRK1B0.38928250
79MUSK0.38401676
80CDC70.37701625
81TEC0.36842041
82PTK2B0.36657798
83CSNK1E0.35898337
84FLT30.34502036
85ATM0.33492478
86PRKG10.32024046
87CDK50.30438000
88ALK0.29937055
89PRKACA0.29516386
90NEK10.28855524
91CAMK2A0.28261960
92OBSCN0.28199342
93PAK30.27751389
94BUB10.27647803
95PRKCI0.26875058
96FGFR10.24405949
97CSNK2A10.24261427
98CSNK1D0.24242145
99CAMK40.23443493
100GRK50.23267348

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030604.48312049
2Sulfur relay system_Homo sapiens_hsa041223.92305327
3Ribosome_Homo sapiens_hsa030103.23095662
4Oxidative phosphorylation_Homo sapiens_hsa001902.99799600
5Parkinsons disease_Homo sapiens_hsa050122.86164653
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.81574041
7Proteasome_Homo sapiens_hsa030502.55496467
8RNA polymerase_Homo sapiens_hsa030202.21081956
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.15431720
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.14971346
11Huntingtons disease_Homo sapiens_hsa050162.14608143
12Basal transcription factors_Homo sapiens_hsa030222.11550782
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.86671775
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.80916184
15Glycosaminoglycan degradation_Homo sapiens_hsa005311.77307699
16Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.72662598
17Propanoate metabolism_Homo sapiens_hsa006401.72191728
18Alzheimers disease_Homo sapiens_hsa050101.70914381
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.67938879
20Cardiac muscle contraction_Homo sapiens_hsa042601.67568471
21Base excision repair_Homo sapiens_hsa034101.53675875
22RNA transport_Homo sapiens_hsa030131.52504465
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.45364924
24Butanoate metabolism_Homo sapiens_hsa006501.44747304
25Steroid biosynthesis_Homo sapiens_hsa001001.40174244
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.34764436
27Peroxisome_Homo sapiens_hsa041461.29598596
28GABAergic synapse_Homo sapiens_hsa047271.25054779
29Vibrio cholerae infection_Homo sapiens_hsa051101.24748640
30Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.21559043
31Biosynthesis of amino acids_Homo sapiens_hsa012301.20790928
32Non-homologous end-joining_Homo sapiens_hsa034501.20200280
33Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.19501641
34Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.16195351
35Cysteine and methionine metabolism_Homo sapiens_hsa002701.14157018
36Spliceosome_Homo sapiens_hsa030401.12954749
37Mismatch repair_Homo sapiens_hsa034301.09982177
38RNA degradation_Homo sapiens_hsa030181.08961999
39Phototransduction_Homo sapiens_hsa047441.07560169
40Pyruvate metabolism_Homo sapiens_hsa006201.05762999
41Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.04042687
42Carbon metabolism_Homo sapiens_hsa012001.01817645
43Glutathione metabolism_Homo sapiens_hsa004801.00913423
44Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.99985340
45Cocaine addiction_Homo sapiens_hsa050300.94416832
46Ether lipid metabolism_Homo sapiens_hsa005650.93251113
47Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.89770523
48Selenocompound metabolism_Homo sapiens_hsa004500.86100946
49Primary bile acid biosynthesis_Homo sapiens_hsa001200.84776979
50Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.81405496
51Metabolic pathways_Homo sapiens_hsa011000.80667090
52Fatty acid elongation_Homo sapiens_hsa000620.79365749
53Linoleic acid metabolism_Homo sapiens_hsa005910.78669859
54Olfactory transduction_Homo sapiens_hsa047400.77876108
55alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.76286537
56Fat digestion and absorption_Homo sapiens_hsa049750.75542563
57Nicotine addiction_Homo sapiens_hsa050330.73572696
58Sulfur metabolism_Homo sapiens_hsa009200.73235921
59Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.70403831
60Purine metabolism_Homo sapiens_hsa002300.70190428
61Fanconi anemia pathway_Homo sapiens_hsa034600.69453383
62Morphine addiction_Homo sapiens_hsa050320.66980583
63Regulation of autophagy_Homo sapiens_hsa041400.65605319
64mRNA surveillance pathway_Homo sapiens_hsa030150.65371450
65Homologous recombination_Homo sapiens_hsa034400.64428918
66Taste transduction_Homo sapiens_hsa047420.59438038
67Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.56608647
68beta-Alanine metabolism_Homo sapiens_hsa004100.56141042
69Basal cell carcinoma_Homo sapiens_hsa052170.55987867
70Sphingolipid metabolism_Homo sapiens_hsa006000.53729575
71Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.51867233
72Pyrimidine metabolism_Homo sapiens_hsa002400.51867028
732-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.51553651
74Cholinergic synapse_Homo sapiens_hsa047250.51048094
75Arginine and proline metabolism_Homo sapiens_hsa003300.48000334
76Collecting duct acid secretion_Homo sapiens_hsa049660.46543998
77Retinol metabolism_Homo sapiens_hsa008300.45857002
78Insulin secretion_Homo sapiens_hsa049110.44922887
79Cyanoamino acid metabolism_Homo sapiens_hsa004600.44441364
80Synaptic vesicle cycle_Homo sapiens_hsa047210.43716012
81Alcoholism_Homo sapiens_hsa050340.43562090
82Glycerophospholipid metabolism_Homo sapiens_hsa005640.43015577
83Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.42609275
84Dopaminergic synapse_Homo sapiens_hsa047280.42160961
85Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.40468758
86Serotonergic synapse_Homo sapiens_hsa047260.40202475
87Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.40152230
88Malaria_Homo sapiens_hsa051440.39815044
89Renin-angiotensin system_Homo sapiens_hsa046140.39763934
90Glutamatergic synapse_Homo sapiens_hsa047240.37797767
91Axon guidance_Homo sapiens_hsa043600.37500380
92SNARE interactions in vesicular transport_Homo sapiens_hsa041300.36358760
93Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.36065230
94Circadian entrainment_Homo sapiens_hsa047130.34642657
95Thyroid hormone synthesis_Homo sapiens_hsa049180.33867866
96Arachidonic acid metabolism_Homo sapiens_hsa005900.33661311
97Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.32885859
98One carbon pool by folate_Homo sapiens_hsa006700.31867070
99Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.30496289
100Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.29584715

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