TDH

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synapsis (GO:0007129)6.41331203
2regulation of gene silencing by RNA (GO:0060966)5.59062608
3regulation of posttranscriptional gene silencing (GO:0060147)5.59062608
4regulation of gene silencing by miRNA (GO:0060964)5.59062608
5male meiosis (GO:0007140)5.53161940
6protoporphyrinogen IX metabolic process (GO:0046501)5.29285734
7chromosome organization involved in meiosis (GO:0070192)5.10480481
8DNA replication initiation (GO:0006270)4.94306684
9positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.94126366
10formation of translation preinitiation complex (GO:0001731)4.80690727
11nucleobase biosynthetic process (GO:0046112)4.68355578
12regulation of oxidative stress-induced neuron death (GO:1903203)4.58905941
13regulation of helicase activity (GO:0051095)4.58166727
14somatic diversification of immune receptors via somatic mutation (GO:0002566)4.56844743
15somatic hypermutation of immunoglobulin genes (GO:0016446)4.56844743
16DNA replication-dependent nucleosome organization (GO:0034723)4.52081981
17DNA replication-dependent nucleosome assembly (GO:0006335)4.52081981
18regulation of oxidative phosphorylation (GO:0002082)4.51805819
19nuclear pore organization (GO:0006999)4.48807359
20mitotic metaphase plate congression (GO:0007080)4.40297600
21protoporphyrinogen IX biosynthetic process (GO:0006782)4.39657108
22purine nucleobase biosynthetic process (GO:0009113)4.39412168
23DNA strand elongation involved in DNA replication (GO:0006271)4.38401292
24IMP biosynthetic process (GO:0006188)4.35057956
25porphyrin-containing compound biosynthetic process (GO:0006779)4.31795087
26positive regulation of catecholamine secretion (GO:0033605)4.28274546
27ribosome assembly (GO:0042255)4.23958784
28DNA double-strand break processing (GO:0000729)4.23109815
29synaptonemal complex assembly (GO:0007130)4.19718443
30DNA replication checkpoint (GO:0000076)4.18181285
31DNA unwinding involved in DNA replication (GO:0006268)4.18069074
32ribosome biogenesis (GO:0042254)4.15923381
33DNA strand elongation (GO:0022616)4.13794604
34maturation of SSU-rRNA (GO:0030490)4.11233478
35nuclear pore complex assembly (GO:0051292)4.10674797
36folic acid-containing compound biosynthetic process (GO:0009396)4.09348766
37DNA synthesis involved in DNA repair (GO:0000731)4.08195357
38attachment of spindle microtubules to kinetochore (GO:0008608)4.02573705
39mitotic nuclear envelope disassembly (GO:0007077)4.01425642
40histone exchange (GO:0043486)4.00973648
41gas transport (GO:0015669)4.00868263
42telomere maintenance via semi-conservative replication (GO:0032201)3.94604944
43protein localization to kinetochore (GO:0034501)3.94131942
44potassium ion export (GO:0071435)3.92821568
45regulation of autophagic vacuole assembly (GO:2000785)3.90926733
46erythrocyte maturation (GO:0043249)3.89596250
47regulation of phosphoprotein phosphatase activity (GO:0043666)3.87871043
48determination of adult lifespan (GO:0008340)3.87800808
49oxygen transport (GO:0015671)3.81141036
50TOR signaling (GO:0031929)3.80295183
51tetrapyrrole biosynthetic process (GO:0033014)3.79788301
52regulation of nuclear cell cycle DNA replication (GO:0033262)3.77942137
53IMP metabolic process (GO:0046040)3.72968714
54membrane disassembly (GO:0030397)3.72531474
55nuclear envelope disassembly (GO:0051081)3.72531474
56meiotic nuclear division (GO:0007126)3.71233875
57metaphase plate congression (GO:0051310)3.69153129
58synaptonemal complex organization (GO:0070193)3.67963494
59ribonucleoprotein complex biogenesis (GO:0022613)3.67289747
60histone arginine methylation (GO:0034969)3.66778982
61binding of sperm to zona pellucida (GO:0007339)3.66113935
62nucleosome disassembly (GO:0006337)3.63857908
63protein-DNA complex disassembly (GO:0032986)3.63857908
64resolution of meiotic recombination intermediates (GO:0000712)3.58167203
65histone H4-K12 acetylation (GO:0043983)3.58025798
66isoprenoid biosynthetic process (GO:0008299)3.57042745
67meiotic chromosome segregation (GO:0045132)3.56532847
68regulation of RNA export from nucleus (GO:0046831)3.52458582
69negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)3.52440171
70DNA geometric change (GO:0032392)3.50685361
71DNA duplex unwinding (GO:0032508)3.50492059
72acrosome reaction (GO:0007340)3.46078367
73motile cilium assembly (GO:0044458)3.45097254
74mitotic sister chromatid segregation (GO:0000070)3.44508306
75telomere maintenance via recombination (GO:0000722)3.41488986
76telomere maintenance via telomere lengthening (GO:0010833)3.41331145
77spermatid development (GO:0007286)3.39964629
78positive regulation of SMAD protein import into nucleus (GO:0060391)3.39000833
79DNA methylation involved in gamete generation (GO:0043046)3.37598167
80negative regulation of androgen receptor signaling pathway (GO:0060766)3.36476189
81anterior/posterior axis specification, embryo (GO:0008595)3.35576200
82centriole assembly (GO:0098534)3.33842531
83porphyrin-containing compound metabolic process (GO:0006778)3.33576191
84regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.32656650
85regulation of histone H3-K9 methylation (GO:0051570)3.32340306
86rRNA processing (GO:0006364)3.27967855
87mitotic recombination (GO:0006312)3.27723231
88protein K6-linked ubiquitination (GO:0085020)3.25818902
89chromatin remodeling at centromere (GO:0031055)3.25614662
90protein localization to chromosome, centromeric region (GO:0071459)3.25358101
91spermatid nucleus differentiation (GO:0007289)3.23649186
92heterochromatin organization (GO:0070828)3.23131490
93male meiosis I (GO:0007141)3.22939447
94DNA topological change (GO:0006265)3.21175182
95establishment of chromosome localization (GO:0051303)3.21140038
96ribosomal large subunit biogenesis (GO:0042273)3.20882258
97coenzyme catabolic process (GO:0009109)3.20799446
98negative regulation of organelle assembly (GO:1902116)3.19851957
99regulation of spindle organization (GO:0090224)3.19555090
100rRNA modification (GO:0000154)3.19347574
101folic acid metabolic process (GO:0046655)3.18108588
102regulation of telomere maintenance via telomerase (GO:0032210)3.17534077
103rRNA metabolic process (GO:0016072)3.16450427
104ribosomal small subunit biogenesis (GO:0042274)3.15816972
105negative regulation of histone methylation (GO:0031061)3.15360708
106regulation of gene silencing (GO:0060968)3.14878574
107DNA deamination (GO:0045006)3.14551149
108positive regulation of chromosome segregation (GO:0051984)3.13742581
109ADP metabolic process (GO:0046031)3.13672976
110pore complex assembly (GO:0046931)3.13425807
111nucleotide-excision repair, DNA gap filling (GO:0006297)3.13003499
112regulation of mitotic spindle organization (GO:0060236)3.12764955
113regulation of centriole replication (GO:0046599)3.12621642
114regulation of double-strand break repair via homologous recombination (GO:0010569)3.12333712
115kinetochore assembly (GO:0051382)3.12144320
116spliceosomal snRNP assembly (GO:0000387)3.12126812
117regulation of translational fidelity (GO:0006450)3.11892839
118establishment of protein localization to mitochondrial membrane (GO:0090151)3.11017562
119establishment of integrated proviral latency (GO:0075713)3.10289443
120kinetochore organization (GO:0051383)3.09584733
121response to muscle activity (GO:0014850)3.08813693
122meiotic cell cycle process (GO:1903046)3.08798554
123histone H3-K9 demethylation (GO:0033169)3.07589531
124regulation of vacuole organization (GO:0044088)3.07107044
125paraxial mesoderm development (GO:0048339)3.06214871
126regulation of centrosome cycle (GO:0046605)3.05611728
127CENP-A containing nucleosome assembly (GO:0034080)3.04832414
128embryonic body morphogenesis (GO:0010172)3.04774406
129regulation of nucleobase-containing compound transport (GO:0032239)3.03924613
130negative regulation of gene silencing (GO:0060969)3.02305434
131mismatch repair (GO:0006298)3.01228177
132transcription-coupled nucleotide-excision repair (GO:0006283)3.00968363
133translational initiation (GO:0006413)3.00231647
134negative regulation of epidermal cell differentiation (GO:0045605)3.00167818
135maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.98936202
136ribosomal small subunit assembly (GO:0000028)2.97625901
137pre-miRNA processing (GO:0031054)2.96289774
138DNA replication-independent nucleosome assembly (GO:0006336)2.95356988
139DNA replication-independent nucleosome organization (GO:0034724)2.95356988
140chromosome segregation (GO:0007059)2.94872688
141nodal signaling pathway (GO:0038092)2.94218075
142sister chromatid segregation (GO:0000819)2.92027846
143regulation of translation in response to stress (GO:0043555)2.91708067
144pseudouridine synthesis (GO:0001522)2.91384745
145tRNA aminoacylation for protein translation (GO:0006418)2.88962243
146maturation of 5.8S rRNA (GO:0000460)2.88527568
147viral transcription (GO:0019083)2.88267712
148translational termination (GO:0006415)2.87880180
149chaperone-mediated protein complex assembly (GO:0051131)2.86368063
150regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.85975330
151peptidyl-arginine omega-N-methylation (GO:0035247)2.85974004
152negative regulation of chromosome segregation (GO:0051985)2.84979101
153establishment of mitotic spindle localization (GO:0040001)2.84449253
154regulation of DNA endoreduplication (GO:0032875)2.83990430
155transcription from RNA polymerase I promoter (GO:0006360)2.83076033
156mitotic chromosome condensation (GO:0007076)2.81842019
157regulation of cellular respiration (GO:0043457)2.77988388
158regulation of meiosis I (GO:0060631)2.76867845
159mRNA cleavage (GO:0006379)2.75445069
160microtubule depolymerization (GO:0007019)2.75030126
161DNA catabolic process, exonucleolytic (GO:0000738)2.74673087
162acrosome assembly (GO:0001675)2.74204173
163centriole replication (GO:0007099)2.74044375
164protein complex localization (GO:0031503)2.73702724
165nucleoside diphosphate biosynthetic process (GO:0009133)2.72401619
166serine family amino acid catabolic process (GO:0009071)2.68338005
167sister chromatid cohesion (GO:0007062)2.65348813
168piRNA metabolic process (GO:0034587)2.65241343
169cellular response to toxic substance (GO:0097237)2.64865453
170sperm-egg recognition (GO:0035036)2.64769232
171muscle cell cellular homeostasis (GO:0046716)2.63723337
172erythrocyte development (GO:0048821)2.63628191
173protein localization to chromosome (GO:0034502)2.63346088
174chromosome organization (GO:0051276)2.63040488
175diterpenoid biosynthetic process (GO:0016102)2.62937715
176nucleosome assembly (GO:0006334)2.62260995
177meiosis I (GO:0007127)2.61088363
178sperm motility (GO:0030317)2.60630686
179regulation of chromosome segregation (GO:0051983)2.60589989
180iron ion import (GO:0097286)2.58272195
181regulation of hydrogen peroxide-induced cell death (GO:1903205)2.56996771
182nucleosome organization (GO:0034728)2.56532005

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.97198971
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.08861353
3GATA1_22025678_ChIP-Seq_K562_Human4.43852113
4MYC_18555785_ChIP-Seq_MESCs_Mouse4.15314503
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.41187291
6MYC_19079543_ChIP-ChIP_MESCs_Mouse3.36118748
7KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.31444892
8KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.31444892
9KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.31444892
10FOXM1_23109430_ChIP-Seq_U2OS_Human3.24082588
11* SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.09954021
12POU5F1_18700969_ChIP-ChIP_MESCs_Mouse3.06998151
13E2F4_17652178_ChIP-ChIP_JURKAT_Human3.01716705
14EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.85212324
15* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.80367013
16NANOG_18555785_ChIP-Seq_MESCs_Mouse2.77433668
17* NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.64323464
18* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.59264594
19NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.58586750
20FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.47003638
21IGF1R_20145208_ChIP-Seq_DFB_Human2.38763429
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.33142377
23* TCF3_18692474_ChIP-Seq_MEFs_Mouse2.32833884
24EST1_17652178_ChIP-ChIP_JURKAT_Human2.27131978
25KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.26160776
26STAT3_1855785_ChIP-Seq_MESCs_Mouse2.23798071
27POU5F1_18358816_ChIP-ChIP_MESCs_Mouse2.22953997
28ETS1_20019798_ChIP-Seq_JURKAT_Human2.21127701
29NELFA_20434984_ChIP-Seq_ESCs_Mouse2.20479700
30* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.17529618
31POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.16539194
32MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.15899806
33E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.08226101
34SOX2_18555785_ChIP-Seq_MESCs_Mouse2.02963469
35SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.01901466
36* TCF3_18692474_ChIP-Seq_MESCs_Mouse2.01633673
37HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.00876163
38* SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.00259838
39* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.99307518
40XRN2_22483619_ChIP-Seq_HELA_Human1.92722193
41CREB1_15753290_ChIP-ChIP_HEK293T_Human1.91869596
42KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.91032196
43GABP_17652178_ChIP-ChIP_JURKAT_Human1.88768072
44* GATA1_19941826_ChIP-Seq_K562_Human1.85223684
45MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.82758433
46MYCN_18555785_ChIP-Seq_MESCs_Mouse1.79133249
47SALL1_21062744_ChIP-ChIP_HESCs_Human1.77882537
48ESR1_20079471_ChIP-ChIP_T-47D_Human1.77279938
49* NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.76669301
50* ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.74697228
51ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.73075470
52* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.68034902
53* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.67973773
54NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.65482019
55ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.65277010
56YY1_21170310_ChIP-Seq_MESCs_Mouse1.64885927
57* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.63563001
58E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.61579354
59* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.58392545
60THAP11_20581084_ChIP-Seq_MESCs_Mouse1.56847838
61CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.56723611
62AR_21909140_ChIP-Seq_LNCAP_Human1.55678286
63STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.55460409
64VDR_23849224_ChIP-Seq_CD4+_Human1.54036049
65E2F1_21310950_ChIP-Seq_MCF-7_Human1.51403765
66ESR1_15608294_ChIP-ChIP_MCF-7_Human1.51177703
67ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.46608754
68* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.46171208
69* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.44763126
70EGR1_19374776_ChIP-ChIP_THP-1_Human1.44427011
71DCP1A_22483619_ChIP-Seq_HELA_Human1.42877885
72TTF2_22483619_ChIP-Seq_HELA_Human1.41785174
73* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.41214083
74* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.40830756
75CHD1_26751641_Chip-Seq_LNCaP_Human1.39865356
76* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.39592041
77* NCOR1_26117541_ChIP-Seq_K562_Human1.35584763
78* POU5F1_16518401_ChIP-PET_MESCs_Mouse1.35341508
79FOXP3_21729870_ChIP-Seq_TREG_Human1.35108540
80EZH2_22144423_ChIP-Seq_EOC_Human1.34411823
81GABP_19822575_ChIP-Seq_HepG2_Human1.33642884
82KLF4_18555785_ChIP-Seq_MESCs_Mouse1.33500690
83* GATA2_19941826_ChIP-Seq_K562_Human1.32398284
84NANOG_21062744_ChIP-ChIP_HESCs_Human1.30598718
85* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.28955645
86YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.27368013
87ER_23166858_ChIP-Seq_MCF-7_Human1.26452578
88PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.25778681
89* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.24592549
90E2F1_17053090_ChIP-ChIP_MCF-7_Human1.23592609
91HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.22775558
92ZFX_18555785_ChIP-Seq_MESCs_Mouse1.20676290
93ZNF263_19887448_ChIP-Seq_K562_Human1.20482398
94PKCTHETA_26484144_Chip-Seq_BREAST_Human1.18639239
95CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.16946402
96NANOG_20526341_ChIP-Seq_ESCs_Human1.16693465
97* KAP1_27257070_Chip-Seq_ESCs_Mouse1.14148758
98KDM5A_27292631_Chip-Seq_BREAST_Human1.13157184
99ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.12756958
100MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.11534047
101HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.09574422
102PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09430892
103CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.06955822
104ERA_21632823_ChIP-Seq_H3396_Human1.06402065
105PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.05881964
106PHF8_20622854_ChIP-Seq_HELA_Human1.05493962
107CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.05301249
108CIITA_25753668_ChIP-Seq_RAJI_Human1.03828724
109* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.03770530
110TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.03540361
111MYC_18940864_ChIP-ChIP_HL60_Human1.03456371
112SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.01939956
113MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.01560665
114ELK1_19687146_ChIP-ChIP_HELA_Human1.01234595
115TFEB_21752829_ChIP-Seq_HELA_Human1.00961089
116BP1_19119308_ChIP-ChIP_Hs578T_Human1.00728719
117TBX5_21415370_ChIP-Seq_HL-1_Mouse0.99257252
118PADI4_21655091_ChIP-ChIP_MCF-7_Human0.98868819
119SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.98100072
120MYC_22102868_ChIP-Seq_BL_Human0.96608870
121CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.95289213
122* NANOG_16518401_ChIP-PET_MESCs_Mouse0.94949891
123CTCF_21964334_Chip-Seq_Bcells_Human0.94338036
124PHF8_20622853_ChIP-Seq_HELA_Human0.93787131
125TBL1_22424771_ChIP-Seq_293T_Human0.92546916
126DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.92176772
127GATA1_26923725_Chip-Seq_HPCs_Mouse0.90769590
128FUS_26573619_Chip-Seq_HEK293_Human0.90506497
129TP63_19390658_ChIP-ChIP_HaCaT_Human0.90402329
130* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.90219128
131GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.87867256
132SRF_21415370_ChIP-Seq_HL-1_Mouse0.86968341
133SOX2_16153702_ChIP-ChIP_HESCs_Human0.85726501
134CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.85480290
135SCL_19346495_ChIP-Seq_HPC-7_Human0.85431997
136* IRF1_19129219_ChIP-ChIP_H3396_Human0.85355702
137TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.84849260
138NFYB_21822215_ChIP-Seq_K562_Human0.84443170
139PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.83600701
140GATA6_21074721_ChIP-Seq_CACO-2_Human0.83096884
141GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.82463497
142BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.81519271
143ELF1_17652178_ChIP-ChIP_JURKAT_Human0.81097881
144P68_20966046_ChIP-Seq_HELA_Human0.80440796
145SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.80373800
146CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.79747097

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.68692770
2MP0003693_abnormal_embryo_hatching4.62357503
3MP0004957_abnormal_blastocyst_morpholog4.54693828
4MP0010094_abnormal_chromosome_stability4.32985171
5MP0003111_abnormal_nucleus_morphology4.30646569
6MP0003806_abnormal_nucleotide_metabolis4.15597629
7MP0004147_increased_porphyrin_level3.69457044
8MP0003077_abnormal_cell_cycle3.67131324
9MP0008004_abnormal_stomach_pH3.39761640
10MP0008058_abnormal_DNA_repair3.32758100
11MP0004133_heterotaxia3.25530000
12MP0008995_early_reproductive_senescence3.16741228
13MP0003656_abnormal_erythrocyte_physiolo2.88229380
14MP0010352_gastrointestinal_tract_polyps2.87327978
15MP0002653_abnormal_ependyma_morphology2.74469571
16MP0005410_abnormal_fertilization2.65018771
17MP0000749_muscle_degeneration2.64031525
18MP0003283_abnormal_digestive_organ2.63211290
19MP0005083_abnormal_biliary_tract2.52971857
20MP0001730_embryonic_growth_arrest2.51592770
21MP0008932_abnormal_embryonic_tissue2.45735281
22MP0003123_paternal_imprinting2.42936208
23MP0000350_abnormal_cell_proliferation2.33551031
24MP0002837_dystrophic_cardiac_calcinosis2.29053191
25MP0008007_abnormal_cellular_replicative2.28179197
26MP0009697_abnormal_copulation2.19227157
27MP0002132_abnormal_respiratory_system2.14355523
28MP0003941_abnormal_skin_development2.13852100
29MP0003718_maternal_effect2.03718407
30MP0003136_yellow_coat_color2.02921182
31MP0005646_abnormal_pituitary_gland1.97554092
32MP0005380_embryogenesis_phenotype1.97152643
33MP0001672_abnormal_embryogenesis/_devel1.97152643
34MP0003786_premature_aging1.93427212
35MP0002085_abnormal_embryonic_tissue1.91772717
36MP0002084_abnormal_developmental_patter1.88514557
37MP0010307_abnormal_tumor_latency1.86543471
38MP0001697_abnormal_embryo_size1.81004934
39MP0003890_abnormal_embryonic-extraembry1.76662919
40MP0000566_synostosis1.75996277
41MP0002086_abnormal_extraembryonic_tissu1.69941461
42MP0006292_abnormal_olfactory_placode1.66337541
43MP0004197_abnormal_fetal_growth/weight/1.64186289
44MP0002080_prenatal_lethality1.63524505
45MP0003984_embryonic_growth_retardation1.63339317
46MP0006036_abnormal_mitochondrial_physio1.63142972
47MP0003119_abnormal_digestive_system1.62963103
48MP0001293_anophthalmia1.62259620
49MP0002088_abnormal_embryonic_growth/wei1.59963231
50MP0005394_taste/olfaction_phenotype1.53954120
51MP0005499_abnormal_olfactory_system1.53954120
52MP0008877_abnormal_DNA_methylation1.53335825
53MP0000678_abnormal_parathyroid_gland1.52341825
54MP0001529_abnormal_vocalization1.49090088
55MP0004084_abnormal_cardiac_muscle1.38402058
56MP0010030_abnormal_orbit_morphology1.37259903
57MP0005266_abnormal_metabolism1.36975041
58MP0001346_abnormal_lacrimal_gland1.35721119
59MP0005076_abnormal_cell_differentiation1.32912149
60MP0008789_abnormal_olfactory_epithelium1.31227334
61MP0002210_abnormal_sex_determination1.29949425
62MP0001145_abnormal_male_reproductive1.25258696
63MP0005187_abnormal_penis_morphology1.25130599
64MP0000313_abnormal_cell_death1.24751220
65MP0003567_abnormal_fetal_cardiomyocyte1.21761683
66MP0000631_abnormal_neuroendocrine_gland1.20230083
67MP0004264_abnormal_extraembryonic_tissu1.18893102
68MP0003121_genomic_imprinting1.18149127
69MP0001188_hyperpigmentation1.17139768
70MP0001849_ear_inflammation1.16379589
71MP0003186_abnormal_redox_activity1.15419614
72MP0005248_abnormal_Harderian_gland1.15188766
73MP0005647_abnormal_sex_gland1.15136459
74MP0005423_abnormal_somatic_nervous1.13779723
75MP0000490_abnormal_crypts_of1.13349442
76MP0002019_abnormal_tumor_incidence1.11257189
77MP0005451_abnormal_body_composition1.10632970
78MP0003566_abnormal_cell_adhesion1.09589556
79MP0000516_abnormal_urinary_system1.09391346
80MP0005367_renal/urinary_system_phenotyp1.09391346
81MP0003699_abnormal_female_reproductive1.07742929
82MP0003705_abnormal_hypodermis_morpholog1.05151030
83MP0003315_abnormal_perineum_morphology1.02414655
84MP0000462_abnormal_digestive_system1.01840764
85MP0004145_abnormal_muscle_electrophysio0.99450270
86MP0001929_abnormal_gametogenesis0.98629948
87MP0003385_abnormal_body_wall0.98202238
88MP0000653_abnormal_sex_gland0.96378670
89MP0005023_abnormal_wound_healing0.94852095
90MP0002111_abnormal_tail_morphology0.93330011
91MP0002160_abnormal_reproductive_system0.92512580
92MP0005058_abnormal_lysosome_morphology0.91529953
93MP0005501_abnormal_skin_physiology0.91509221
94MP0001666_abnormal_nutrient_absorption0.89478153
95MP0001286_abnormal_eye_development0.88602581
96MP0003936_abnormal_reproductive_system0.88011562
97MP0008961_abnormal_basal_metabolism0.84682158
98MP0000358_abnormal_cell_content/0.83907588
99MP0001764_abnormal_homeostasis0.83304519
100MP0002108_abnormal_muscle_morphology0.81387960
101MP0004036_abnormal_muscle_relaxation0.80977776
102MP0000372_irregular_coat_pigmentation0.80872373
103MP0002233_abnormal_nose_morphology0.80614105
104MP0005384_cellular_phenotype0.79592186
105MP0005389_reproductive_system_phenotype0.79148692
106MP0002269_muscular_atrophy0.77714189
107MP0002796_impaired_skin_barrier0.77307513
108MP0005330_cardiomyopathy0.77247116
109MP0000537_abnormal_urethra_morphology0.76970236
110MP0000371_diluted_coat_color0.75980274
111MP0006035_abnormal_mitochondrial_morpho0.75414990
112MP0003938_abnormal_ear_development0.75027493
113MP0003868_abnormal_feces_composition0.74814559
114MP0009840_abnormal_foam_cell0.74716927
115MP0005621_abnormal_cell_physiology0.74400835
116MP0005636_abnormal_mineral_homeostasis0.74286122
117MP0002277_abnormal_respiratory_mucosa0.73767028
118MP0002102_abnormal_ear_morphology0.73654150
119MP0003861_abnormal_nervous_system0.72735653
120MP0005551_abnormal_eye_electrophysiolog0.71760812
121MP0005395_other_phenotype0.70697827
122MP0000747_muscle_weakness0.69057464
123MP0009053_abnormal_anal_canal0.68798539
124MP0001661_extended_life_span0.67816206
125MP0009703_decreased_birth_body0.67558828
126MP0009250_abnormal_appendicular_skeleto0.66902116
127MP0003879_abnormal_hair_cell0.66225321
128MP0000750_abnormal_muscle_regeneration0.66192832
129MP0001119_abnormal_female_reproductive0.65911721
130MP0004087_abnormal_muscle_fiber0.65890636
131MP0002092_abnormal_eye_morphology0.65735843
132MP0000432_abnormal_head_morphology0.65152829
133MP0002249_abnormal_larynx_morphology0.64954756
134MP0008770_decreased_survivor_rate0.64938293
135MP0003698_abnormal_male_reproductive0.64434313
136MP0002332_abnormal_exercise_endurance0.63882974
137MP0002127_abnormal_cardiovascular_syste0.63557298
138MP0002075_abnormal_coat/hair_pigmentati0.63301793
139MP0002697_abnormal_eye_size0.62938800
140MP0003937_abnormal_limbs/digits/tail_de0.61437460
141MP0002396_abnormal_hematopoietic_system0.60325767
142MP0000858_altered_metastatic_potential0.59757247
143MP0006072_abnormal_retinal_apoptosis0.58933088
144MP0000477_abnormal_intestine_morphology0.58675109
145MP0002161_abnormal_fertility/fecundity0.58476505
146MP0001919_abnormal_reproductive_system0.57241882
147MP0003755_abnormal_palate_morphology0.56815988
148MP0001915_intracranial_hemorrhage0.55973147
149MP0000470_abnormal_stomach_morphology0.55102960
150MP0004233_abnormal_muscle_weight0.55091644
151MP0000627_abnormal_mammary_gland0.53636968

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)5.42289003
2Birth length less than 3rd percentile (HP:0003561)5.08014648
3Reticulocytosis (HP:0001923)4.96824564
4Breast hypoplasia (HP:0003187)4.95326389
5Abnormality of the heme biosynthetic pathway (HP:0010472)4.86004062
6Poikilocytosis (HP:0004447)4.82306257
7Abnormality of the labia minora (HP:0012880)4.63123941
8Cholecystitis (HP:0001082)3.92793151
9Abnormal gallbladder physiology (HP:0012438)3.92793151
10Abnormality of reticulocytes (HP:0004312)3.90299065
11Medulloblastoma (HP:0002885)3.88238893
12Supernumerary spleens (HP:0009799)3.85774608
13Absent radius (HP:0003974)3.82597553
14Astrocytoma (HP:0009592)3.79130878
15Abnormality of the astrocytes (HP:0100707)3.79130878
16High anterior hairline (HP:0009890)3.75207414
17Selective tooth agenesis (HP:0001592)3.72898828
18Facial hemangioma (HP:0000329)3.66734998
19Colon cancer (HP:0003003)3.63970914
20Agnosia (HP:0010524)3.63888835
21Resting tremor (HP:0002322)3.61628073
22Aplasia involving forearm bones (HP:0009822)3.59660700
23Absent forearm bone (HP:0003953)3.59660700
24Neoplasm of the oral cavity (HP:0100649)3.54375540
25Carpal bone hypoplasia (HP:0001498)3.50813231
26Aplasia/hypoplasia of the humerus (HP:0006507)3.32760025
27Aplasia involving bones of the extremities (HP:0009825)3.32609723
28Aplasia involving bones of the upper limbs (HP:0009823)3.32609723
29Aplasia of the phalanges of the hand (HP:0009802)3.32609723
30Rhabdomyosarcoma (HP:0002859)3.32268767
31Chromosomal breakage induced by crosslinking agents (HP:0003221)3.30978606
32Glioma (HP:0009733)3.25837093
33Cerebral hypomyelination (HP:0006808)3.23706278
34Patellar aplasia (HP:0006443)3.23231450
35Chromsome breakage (HP:0040012)3.22465259
36Impulsivity (HP:0100710)3.15771889
37Rib fusion (HP:0000902)3.09864111
38Diaphragmatic weakness (HP:0009113)3.06086786
39Long clavicles (HP:0000890)3.05393402
40Alacrima (HP:0000522)3.03307538
41Abnormality of abdominal situs (HP:0011620)3.01472212
42Abdominal situs inversus (HP:0003363)3.01472212
43Short humerus (HP:0005792)3.01007581
44Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.99000354
45Oral leukoplakia (HP:0002745)2.98314822
46Absent thumb (HP:0009777)2.96994905
47Aplasia/Hypoplasia of the patella (HP:0006498)2.95467582
48Cholelithiasis (HP:0001081)2.91953025
49Hyporeflexia of lower limbs (HP:0002600)2.86449855
50Reticulocytopenia (HP:0001896)2.85378280
51Dynein arm defect of respiratory motile cilia (HP:0012255)2.80990368
52Absent/shortened dynein arms (HP:0200106)2.80990368
53Rectal fistula (HP:0100590)2.79908609
54Rectovaginal fistula (HP:0000143)2.79908609
55Hypoplasia of the uterus (HP:0000013)2.79564221
56Abnormality of the anterior horn cell (HP:0006802)2.78502466
57Degeneration of anterior horn cells (HP:0002398)2.78502466
58Shawl scrotum (HP:0000049)2.78178879
59Abnormality of the salivary glands (HP:0010286)2.77696329
60Rough bone trabeculation (HP:0100670)2.75533188
61Hypoparathyroidism (HP:0000829)2.73025572
62Neoplasm of striated muscle (HP:0009728)2.72886517
63Decreased activity of mitochondrial respiratory chain (HP:0008972)2.72287539
64Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.72287539
65Meckel diverticulum (HP:0002245)2.69086905
66Abnormal number of incisors (HP:0011064)2.67286154
67Abnormality of the ileum (HP:0001549)2.66648719
68Exercise-induced myalgia (HP:0003738)2.62010682
69Postural instability (HP:0002172)2.61914425
70Esophageal atresia (HP:0002032)2.61727391
71Peripheral hypomyelination (HP:0007182)2.61044995
72Decreased lacrimation (HP:0000633)2.60915097
73Truncus arteriosus (HP:0001660)2.59916615
74Abnormal gallbladder morphology (HP:0012437)2.59373564
75Premature ovarian failure (HP:0008209)2.57425762
76Gonadal dysgenesis (HP:0000133)2.57182303
77Missing ribs (HP:0000921)2.55889237
78Aplasia/Hypoplasia of the uvula (HP:0010293)2.55627860
79Trismus (HP:0000211)2.54806297
80Hyperthyroidism (HP:0000836)2.53874896
81Sex reversal (HP:0012245)2.51377774
82Abnormal sex determination (HP:0012244)2.51377774
83Hepatoblastoma (HP:0002884)2.49896562
84Multiple enchondromatosis (HP:0005701)2.48972952
85Abnormality of the preputium (HP:0100587)2.47108773
86Abnormality of the columella (HP:0009929)2.46516674
87Germ cell neoplasia (HP:0100728)2.43679185
88Ventricular fibrillation (HP:0001663)2.43340482
89Basal cell carcinoma (HP:0002671)2.41723614
90Abnormality of chromosome stability (HP:0003220)2.40694545
91Progressive cerebellar ataxia (HP:0002073)2.39321177
92Abnormal hemoglobin (HP:0011902)2.38164488
93Duplicated collecting system (HP:0000081)2.37573007
94Intestinal fistula (HP:0100819)2.35232040
95Stenosis of the external auditory canal (HP:0000402)2.34767669
96Urinary urgency (HP:0000012)2.34456223
97Abnormality of pyrimidine metabolism (HP:0004353)2.34287665
98Vaginal fistula (HP:0004320)2.30938457
99Type II lissencephaly (HP:0007260)2.26810975
100Asplenia (HP:0001746)2.26015165
101Biliary tract neoplasm (HP:0100574)2.25573287
102Rimmed vacuoles (HP:0003805)2.25492558
103Male infertility (HP:0003251)2.24608974
104Neoplasm of the pancreas (HP:0002894)2.24188970
105Abnormality of DNA repair (HP:0003254)2.23385539
106Cortical dysplasia (HP:0002539)2.22981882
107Horseshoe kidney (HP:0000085)2.20866248
108Abnormality of the carotid arteries (HP:0005344)2.19192878
109Tracheoesophageal fistula (HP:0002575)2.18398049
110Acanthocytosis (HP:0001927)2.17726795
111Vertebral clefting (HP:0008428)2.17675846
112Aplasia/Hypoplasia of the earlobes (HP:0009906)2.15245603
113Hyperbilirubinemia (HP:0002904)2.14870530
114Nephroblastoma (Wilms tumor) (HP:0002667)2.14385327
115Adenoma sebaceum (HP:0009720)2.13638144
116Angiofibromas (HP:0010615)2.13638144
117Breast aplasia (HP:0100783)2.12688186
118Aplasia/Hypoplasia of the sternum (HP:0006714)2.11863641
119Small intestinal stenosis (HP:0012848)2.11750578
120Duodenal stenosis (HP:0100867)2.11750578
121Embryonal neoplasm (HP:0002898)2.11545271
122Hypoplastic labia majora (HP:0000059)2.10651825
123Calf muscle hypertrophy (HP:0008981)2.10445527
124Fused cervical vertebrae (HP:0002949)2.10339032
125Premature graying of hair (HP:0002216)2.08340146
126Abnormality of lateral ventricle (HP:0030047)2.08258321
127Aplasia/Hypoplasia of the spleen (HP:0010451)2.08168841
128Cerebellar dysplasia (HP:0007033)2.07034584
129Median cleft lip (HP:0000161)2.06223444
130Tongue fasciculations (HP:0001308)2.06168776
131Spinal muscular atrophy (HP:0007269)2.04794405
132Supernumerary bones of the axial skeleton (HP:0009144)2.04525681
133Gastrointestinal atresia (HP:0002589)2.04067991
134Clumsiness (HP:0002312)2.02707332
135Breech presentation (HP:0001623)2.02067033
136Increased nuchal translucency (HP:0010880)2.01946695
137Abnormal lung lobation (HP:0002101)2.01728851
138Ileus (HP:0002595)2.00503960
139Abnormality of the gallbladder (HP:0005264)1.98166438
140Aplasia/Hypoplasia of the sacrum (HP:0008517)1.97925008
141Abnormality of the lower motor neuron (HP:0002366)1.97540567
142Pallor (HP:0000980)1.97489753
143Cafe-au-lait spot (HP:0000957)1.97243853
144Sloping forehead (HP:0000340)1.97059716
145Delayed puberty (HP:0000823)1.96782572
146Aplasia/Hypoplasia involving the musculature (HP:0001460)1.96660292
147Abnormal trabecular bone morphology (HP:0100671)1.96468895
148Anal stenosis (HP:0002025)1.94815926
149Bowel incontinence (HP:0002607)1.94310807
150Aplasia/Hypoplasia of the breasts (HP:0010311)1.94217465
151Amaurosis fugax (HP:0100576)1.93998321
152Atresia of the external auditory canal (HP:0000413)1.93952569
153Atrophy/Degeneration involving motor neurons (HP:0007373)1.93853135
154Bone marrow hypocellularity (HP:0005528)1.92775659
155Metaphyseal cupping (HP:0003021)1.92147616
156Abnormality of the duodenum (HP:0002246)1.91666459
157Abnormal ciliary motility (HP:0012262)1.91268818
158Morphological abnormality of the inner ear (HP:0011390)1.91242782
159Abnormality of the renal collecting system (HP:0004742)1.91011138
160Hemivertebrae (HP:0002937)1.90933561
161Embryonal renal neoplasm (HP:0011794)1.90502294
162Reduced antithrombin III activity (HP:0001976)1.89681825
163Hypoplasia of the radius (HP:0002984)1.87705938
164Abnormality of cochlea (HP:0000375)1.87292454
165Vertebral fusion (HP:0002948)1.87213969
166Abnormality of cells of the erythroid lineage (HP:0012130)1.86943530
167Abnormality of the labia majora (HP:0012881)1.86278324
168Muscle hypertrophy of the lower extremities (HP:0008968)1.82462250
169Myelodysplasia (HP:0002863)1.81984145
170Capillary hemangiomas (HP:0005306)1.81625625
171Polycythemia (HP:0001901)1.81440946
172Overlapping toe (HP:0001845)1.80197926
173Abnormal large intestine physiology (HP:0012700)1.77777547
174Rhabdomyolysis (HP:0003201)1.75987256
175Myoglobinuria (HP:0002913)1.75608950
176Azoospermia (HP:0000027)1.75044242
177Abnormality of the shoulder girdle musculature (HP:0001435)1.73431048
178Exercise-induced muscle cramps (HP:0003710)1.72483361
179Male pseudohermaphroditism (HP:0000037)1.71374752
180Aplasia/hypoplasia of the uterus (HP:0008684)1.69284405
181Triphalangeal thumb (HP:0001199)1.66413634
182Squamous cell carcinoma (HP:0002860)1.65645937

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PINK17.82741194
2WEE14.59513167
3BUB14.12274941
4MARK33.77011412
5EPHA23.55919115
6CDK123.24597974
7NEK13.21545595
8CDC73.17770847
9TTK2.99010287
10AKT32.72289924
11TSSK62.59355746
12LATS12.40409126
13RPS6KB22.40280769
14EIF2AK12.25261563
15NEK22.21934019
16OBSCN2.20057400
17PLK12.19708138
18PNCK2.15402397
19CDK72.10007828
20SRPK12.07686135
21MAPKAPK31.79266139
22KSR21.78791136
23CCNB11.76771580
24TESK21.75110056
25CHEK21.67550483
26DYRK31.59148683
27ATR1.58482560
28PASK1.57141914
29RAF11.56320652
30PLK31.54533662
31PLK41.53285389
32TLK11.50728236
33FGFR21.50433125
34AURKA1.39236839
35EIF2AK31.37980830
36AURKB1.37587231
37ALK1.31575541
38NUAK11.30842505
39VRK11.28572609
40ACVR1B1.28256545
41NTRK11.28103937
42MAP3K81.28043142
43NME21.27007513
44CHEK11.26655204
45PAK41.25487191
46BMPR1B1.22544243
47NTRK31.21661391
48BCKDK1.16810740
49MAP2K71.15358890
50BRD41.14573033
51PDK21.13054136
52BRSK21.12044709
53STK38L1.07645695
54CDK41.07050976
55NTRK21.04495047
56CDK191.04243837
57ZAK1.03455082
58LATS21.02917616
59MET1.01501283
60CDK21.01058441
61DYRK20.99941442
62STK100.98014626
63PRKCI0.97474330
64MAP3K10.97420910
65PDK30.95705423
66PDK40.95705423
67SCYL20.93883575
68CLK10.92714035
69ATM0.92458550
70STK40.90561518
71PIM10.88748588
72ICK0.87871327
73FLT30.87089967
74MAP3K20.85877339
75MAP3K40.82428100
76CSNK2A20.81732270
77MKNK10.80460230
78NME10.79229585
79TRIB30.78676062
80MKNK20.73999884
81MAPK150.71311163
82MAP4K20.70996191
83CSNK1E0.70799962
84RPS6KB10.68738000
85KSR10.68208355
86CDK10.67272839
87MTOR0.66880046
88STK160.66642951
89DMPK0.65992714
90PAK10.65344631
91CSNK2A10.65072052
92ARAF0.64355335
93CDK30.63294876
94BRSK10.63078121
95BRAF0.61387919
96CDK60.60896249
97PBK0.59583278
98MST40.57975084
99PKN10.57051074
100MELK0.56761732
101TGFBR10.56278713
102CSNK1D0.55046724
103DAPK10.54460136
104RET0.54440165
105TYRO30.53130779
106SGK4940.52433824
107SGK2230.52433824
108TESK10.48184877
109AKT20.47957557
110DDR20.47474448
111YES10.46420597
112PLK20.46138573
113MATK0.46054398
114ILK0.43861298
115MAP3K90.43262753
116PRKDC0.41018982
117EIF2AK20.40320771
118NEK60.40280041
119MAP3K110.39501459
120RPS6KA40.38387026
121TAOK20.36632633
122CSNK1A1L0.35402335
123RPS6KA50.34703648
124EEF2K0.34399085
125MAPKAPK50.34193602
126SGK20.34028923
127MAPK140.33115127
128PRKCQ0.32725148
129MINK10.32261976
130CSNK1G30.32133278
131GRK60.32042549
132ERBB40.31898909
133MAP2K10.29905925
134GSK3B0.29798692
135MAPK10.28364274
136RPS6KA10.28178848
137CDK80.25378165
138MYLK0.25061860
139MAPK100.23347248
140BMX0.22842722
141PKN20.22541649
142AKT10.21387922
143STK380.20943521
144MAP3K100.19281584
145STK30.17724332

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.76350732
2Mismatch repair_Homo sapiens_hsa034304.75388058
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.21065664
4RNA transport_Homo sapiens_hsa030133.34873916
5One carbon pool by folate_Homo sapiens_hsa006703.30442113
6RNA polymerase_Homo sapiens_hsa030203.18632490
7Spliceosome_Homo sapiens_hsa030403.16580279
8Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.09227486
9Ribosome_Homo sapiens_hsa030103.06004178
10Base excision repair_Homo sapiens_hsa034102.81271578
11Nucleotide excision repair_Homo sapiens_hsa034202.81205470
12Homologous recombination_Homo sapiens_hsa034402.78061483
13Proteasome_Homo sapiens_hsa030502.74110401
14Cell cycle_Homo sapiens_hsa041102.36098779
15Fanconi anemia pathway_Homo sapiens_hsa034602.33682212
16Pyrimidine metabolism_Homo sapiens_hsa002402.18513741
17Non-homologous end-joining_Homo sapiens_hsa034501.90438949
18Olfactory transduction_Homo sapiens_hsa047401.81351479
192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.80478258
20Propanoate metabolism_Homo sapiens_hsa006401.77836378
21Gap junction_Homo sapiens_hsa045401.74028745
22mRNA surveillance pathway_Homo sapiens_hsa030151.73713962
23Basal transcription factors_Homo sapiens_hsa030221.73296637
24RNA degradation_Homo sapiens_hsa030181.71288378
25Biosynthesis of amino acids_Homo sapiens_hsa012301.65219932
26p53 signaling pathway_Homo sapiens_hsa041151.60764705
27Cyanoamino acid metabolism_Homo sapiens_hsa004601.57952605
28Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.50241535
29Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.46664359
30Folate biosynthesis_Homo sapiens_hsa007901.39955362
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.35593427
32Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.35047625
33Butanoate metabolism_Homo sapiens_hsa006501.29337704
34Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.26203603
35Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.25904398
36Steroid biosynthesis_Homo sapiens_hsa001001.25638000
37Regulation of autophagy_Homo sapiens_hsa041401.22730352
38Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.13146773
39Purine metabolism_Homo sapiens_hsa002301.10199154
40Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.10110480
41Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.09974945
42Circadian rhythm_Homo sapiens_hsa047101.05676586
43Pancreatic secretion_Homo sapiens_hsa049721.05000003
44Selenocompound metabolism_Homo sapiens_hsa004501.02057751
45Fat digestion and absorption_Homo sapiens_hsa049751.00109249
46Fructose and mannose metabolism_Homo sapiens_hsa000510.98966071
47Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.98394560
48Epstein-Barr virus infection_Homo sapiens_hsa051690.97764195
49Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.95578031
50Phototransduction_Homo sapiens_hsa047440.94532066
51Oocyte meiosis_Homo sapiens_hsa041140.93881324
52Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.91366068
53Systemic lupus erythematosus_Homo sapiens_hsa053220.90590196
54Endometrial cancer_Homo sapiens_hsa052130.90502289
55Carbon metabolism_Homo sapiens_hsa012000.88218930
56Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.86659814
57Drug metabolism - other enzymes_Homo sapiens_hsa009830.85053263
58Glutathione metabolism_Homo sapiens_hsa004800.84351146
59Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.82967264
60Longevity regulating pathway - mammal_Homo sapiens_hsa042110.79517856
61AMPK signaling pathway_Homo sapiens_hsa041520.77284999
62Vitamin B6 metabolism_Homo sapiens_hsa007500.76649903
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.76205197
64Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.75022410
65Viral carcinogenesis_Homo sapiens_hsa052030.72895308
66Hippo signaling pathway_Homo sapiens_hsa043900.72462550
67Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.70197028
68Type II diabetes mellitus_Homo sapiens_hsa049300.68433987
69Mineral absorption_Homo sapiens_hsa049780.68425197
70Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.68107503
71Basal cell carcinoma_Homo sapiens_hsa052170.64753865
72Pentose phosphate pathway_Homo sapiens_hsa000300.62165386
73TGF-beta signaling pathway_Homo sapiens_hsa043500.61996346
74Insulin signaling pathway_Homo sapiens_hsa049100.61442696
75Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.61372533
76Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.59875274
77Arginine and proline metabolism_Homo sapiens_hsa003300.54780407
78Huntingtons disease_Homo sapiens_hsa050160.53657322
79Vascular smooth muscle contraction_Homo sapiens_hsa042700.50597530
80Choline metabolism in cancer_Homo sapiens_hsa052310.49540890
81Glucagon signaling pathway_Homo sapiens_hsa049220.49520712
82Sulfur relay system_Homo sapiens_hsa041220.49119857
83ErbB signaling pathway_Homo sapiens_hsa040120.47922264
84Maturity onset diabetes of the young_Homo sapiens_hsa049500.46956569
85Galactose metabolism_Homo sapiens_hsa000520.46606801
86MicroRNAs in cancer_Homo sapiens_hsa052060.46413060
87Hedgehog signaling pathway_Homo sapiens_hsa043400.45449894
88Notch signaling pathway_Homo sapiens_hsa043300.44738918
89Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.44654112
90Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.44335879
91Thyroid cancer_Homo sapiens_hsa052160.42137506
92HTLV-I infection_Homo sapiens_hsa051660.41921026
93Herpes simplex infection_Homo sapiens_hsa051680.41414957
94Carbohydrate digestion and absorption_Homo sapiens_hsa049730.41404750
95Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.40956798
96Antigen processing and presentation_Homo sapiens_hsa046120.40668897
97Peroxisome_Homo sapiens_hsa041460.40630720
98Protein digestion and absorption_Homo sapiens_hsa049740.40206834
99Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.39639041
100Prolactin signaling pathway_Homo sapiens_hsa049170.38604762
101Ovarian steroidogenesis_Homo sapiens_hsa049130.38172580
102VEGF signaling pathway_Homo sapiens_hsa043700.37513589
103cGMP-PKG signaling pathway_Homo sapiens_hsa040220.36609072
104mTOR signaling pathway_Homo sapiens_hsa041500.36444369
105Estrogen signaling pathway_Homo sapiens_hsa049150.35252850
106Non-small cell lung cancer_Homo sapiens_hsa052230.33976681
107Nicotine addiction_Homo sapiens_hsa050330.33904386
108Tight junction_Homo sapiens_hsa045300.33777602
109Taste transduction_Homo sapiens_hsa047420.32439002
110Bladder cancer_Homo sapiens_hsa052190.31923681
111Glioma_Homo sapiens_hsa052140.31898023
112Central carbon metabolism in cancer_Homo sapiens_hsa052300.31432383
113Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.29493020
114Metabolic pathways_Homo sapiens_hsa011000.28049205
115Arginine biosynthesis_Homo sapiens_hsa002200.26127783
116Alcoholism_Homo sapiens_hsa050340.25215933
117Arachidonic acid metabolism_Homo sapiens_hsa005900.23565546
118HIF-1 signaling pathway_Homo sapiens_hsa040660.23558423
119Linoleic acid metabolism_Homo sapiens_hsa005910.22618825
120Nitrogen metabolism_Homo sapiens_hsa009100.22481537
121Transcriptional misregulation in cancer_Homo sapiens_hsa052020.22294697
122Colorectal cancer_Homo sapiens_hsa052100.21305441
123Small cell lung cancer_Homo sapiens_hsa052220.20385780
124Adherens junction_Homo sapiens_hsa045200.20101352
125Pathways in cancer_Homo sapiens_hsa052000.18507271
126Pyruvate metabolism_Homo sapiens_hsa006200.16612652
127Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.15433053
128Legionellosis_Homo sapiens_hsa051340.13264691
129Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.12956741
130Wnt signaling pathway_Homo sapiens_hsa043100.12795587
131Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.11681965
132Melanoma_Homo sapiens_hsa052180.10288167
133Lysine degradation_Homo sapiens_hsa003100.09896034
134Parkinsons disease_Homo sapiens_hsa050120.09385102
135Phenylalanine metabolism_Homo sapiens_hsa003600.08870902
136alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.08090656
137Renin-angiotensin system_Homo sapiens_hsa046140.07024473
138Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.06510852
139Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.06015935
140Apoptosis_Homo sapiens_hsa042100.05195643
141Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.03941736
142Tyrosine metabolism_Homo sapiens_hsa003500.01122381
143Prion diseases_Homo sapiens_hsa05020-0.0042567

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