TDO2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a heme enzyme that plays a critical role in tryptophan metabolism by catalyzing the first and rate-limiting step of the kynurenine pathway. Increased activity of the encoded protein and subsequent kynurenine production may also play a role in cancer through the suppression of antitumor immune responses, and single nucleotide polymorphisms in this gene may be associated with autism. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1omega-hydroxylase P450 pathway (GO:0097267)8.91072456
2L-phenylalanine catabolic process (GO:0006559)7.69313789
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.69313789
4L-phenylalanine metabolic process (GO:0006558)7.34224487
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.34224487
6* aromatic amino acid family catabolic process (GO:0009074)6.79260628
7drug metabolic process (GO:0017144)6.41110532
8triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.20163850
9bile acid biosynthetic process (GO:0006699)6.15707649
10oxidative demethylation (GO:0070989)6.07634509
11* tryptophan catabolic process (GO:0006569)5.94991512
12* indole-containing compound catabolic process (GO:0042436)5.94991512
13* indolalkylamine catabolic process (GO:0046218)5.94991512
14urea cycle (GO:0000050)5.85524719
15urea metabolic process (GO:0019627)5.85524719
16glyoxylate metabolic process (GO:0046487)5.80615456
17* kynurenine metabolic process (GO:0070189)5.73105645
18alpha-linolenic acid metabolic process (GO:0036109)5.63843603
19* tryptophan metabolic process (GO:0006568)5.60417734
20negative regulation of fibrinolysis (GO:0051918)5.55955859
21complement activation, alternative pathway (GO:0006957)5.53502283
22regulation of protein activation cascade (GO:2000257)5.48310684
23high-density lipoprotein particle remodeling (GO:0034375)5.45540298
24cysteine metabolic process (GO:0006534)5.39187711
25regulation of fibrinolysis (GO:0051917)5.38492487
26nitrogen cycle metabolic process (GO:0071941)5.38256743
27protein carboxylation (GO:0018214)5.36898596
28peptidyl-glutamic acid carboxylation (GO:0017187)5.36898596
29sulfur amino acid catabolic process (GO:0000098)5.36487555
30ethanol metabolic process (GO:0006067)5.22633452
31regulation of plasminogen activation (GO:0010755)5.22034132
32bile acid metabolic process (GO:0008206)5.20936289
33serine family amino acid catabolic process (GO:0009071)5.15018036
34regulation of complement activation (GO:0030449)5.14637121
35phenylpropanoid metabolic process (GO:0009698)5.11804841
36fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.03133620
37S-adenosylmethionine metabolic process (GO:0046500)5.02434515
38homocysteine metabolic process (GO:0050667)4.94297995
39tyrosine metabolic process (GO:0006570)4.88146264
40regulation of triglyceride catabolic process (GO:0010896)4.87909712
41negative regulation of hemostasis (GO:1900047)4.87391682
42negative regulation of blood coagulation (GO:0030195)4.87391682
43* aromatic amino acid family metabolic process (GO:0009072)4.87038461
44acute-phase response (GO:0006953)4.85480703
45regulation of humoral immune response (GO:0002920)4.78803232
46regulation of cholesterol esterification (GO:0010872)4.75727108
47reverse cholesterol transport (GO:0043691)4.73107504
48lysine metabolic process (GO:0006553)4.69646831
49lysine catabolic process (GO:0006554)4.69646831
50protein-lipid complex remodeling (GO:0034368)4.69063504
51macromolecular complex remodeling (GO:0034367)4.69063504
52plasma lipoprotein particle remodeling (GO:0034369)4.69063504
53amino-acid betaine metabolic process (GO:0006577)4.66788094
54* alpha-amino acid catabolic process (GO:1901606)4.65861156
55negative regulation of protein activation cascade (GO:2000258)4.63785134
56opsonization (GO:0008228)4.63308389
57acylglycerol homeostasis (GO:0055090)4.58448847
58triglyceride homeostasis (GO:0070328)4.58448847
59coenzyme catabolic process (GO:0009109)4.52288627
60negative regulation of cholesterol transport (GO:0032375)4.52027803
61negative regulation of sterol transport (GO:0032372)4.52027803
62phospholipid efflux (GO:0033700)4.48343576
63bile acid and bile salt transport (GO:0015721)4.46974226
64glycine metabolic process (GO:0006544)4.45772250
65negative regulation of coagulation (GO:0050819)4.45045448
66disruption of cells of other organism involved in symbiotic interaction (GO:0051818)4.44576556
67killing of cells in other organism involved in symbiotic interaction (GO:0051883)4.44576556
68positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.43119176
69imidazole-containing compound metabolic process (GO:0052803)4.40648807
70negative regulation of wound healing (GO:0061045)4.39272860
71cellular glucuronidation (GO:0052695)4.38806648
72cellular ketone body metabolic process (GO:0046950)4.37610843
73plasma lipoprotein particle clearance (GO:0034381)4.28611380
74* cellular amino acid catabolic process (GO:0009063)4.28304132
75glutamate metabolic process (GO:0006536)4.27651998
76serine family amino acid metabolic process (GO:0009069)4.23506919
77flavonoid metabolic process (GO:0009812)4.17692644
78cholesterol efflux (GO:0033344)4.16946719
79ethanol oxidation (GO:0006069)4.15534641
80alkaloid metabolic process (GO:0009820)4.14752751
81* indolalkylamine metabolic process (GO:0006586)4.13119367
82positive regulation of hemostasis (GO:1900048)4.09282780
83positive regulation of blood coagulation (GO:0030194)4.09282780
84arginine metabolic process (GO:0006525)4.08944065
85cellular modified amino acid catabolic process (GO:0042219)4.08747733
86dicarboxylic acid biosynthetic process (GO:0043650)4.08487185
87hormone catabolic process (GO:0042447)4.07584703
88intestinal cholesterol absorption (GO:0030299)4.06123552
89serine family amino acid biosynthetic process (GO:0009070)4.03431468
90aldehyde catabolic process (GO:0046185)4.01328866
91* cellular biogenic amine catabolic process (GO:0042402)4.00040063
92* amine catabolic process (GO:0009310)4.00040063
93fibrinolysis (GO:0042730)3.99290167
94drug catabolic process (GO:0042737)3.96912217
95response to mercury ion (GO:0046689)3.96102817
96low-density lipoprotein particle remodeling (GO:0034374)3.94367445
97plasma lipoprotein particle assembly (GO:0034377)3.92850727
98* benzene-containing compound metabolic process (GO:0042537)3.92170632
99cytolysis (GO:0019835)3.90144476
100glucuronate metabolic process (GO:0019585)3.89433146
101uronic acid metabolic process (GO:0006063)3.89433146
102complement activation, classical pathway (GO:0006958)3.87932647
103fat-soluble vitamin biosynthetic process (GO:0042362)3.86656432
104cofactor catabolic process (GO:0051187)3.86078177
105blood coagulation, intrinsic pathway (GO:0007597)3.83812210
106complement activation (GO:0006956)3.83185442
107regulation of bile acid biosynthetic process (GO:0070857)3.80356800
108positive regulation of coagulation (GO:0050820)3.78893041
109ketone body metabolic process (GO:1902224)3.78759374
110protein activation cascade (GO:0072376)3.77744722
111very-low-density lipoprotein particle assembly (GO:0034379)3.76806304
112polyketide metabolic process (GO:0030638)3.76794011
113doxorubicin metabolic process (GO:0044598)3.76794011
114daunorubicin metabolic process (GO:0044597)3.76794011
115positive regulation of lipid catabolic process (GO:0050996)3.74811849
116* organic acid catabolic process (GO:0016054)3.74777543
117* carboxylic acid catabolic process (GO:0046395)3.74777543
118positive regulation of lipoprotein lipase activity (GO:0051006)3.73390365
119positive regulation of triglyceride lipase activity (GO:0061365)3.73390365
120phospholipid homeostasis (GO:0055091)3.73199389
121negative regulation of lipase activity (GO:0060192)3.72109213
122cholesterol homeostasis (GO:0042632)3.71861428
123epoxygenase P450 pathway (GO:0019373)3.69376676
124xenobiotic metabolic process (GO:0006805)3.68694997
125negative regulation of complement activation (GO:0045916)3.67333469
126sterol homeostasis (GO:0055092)3.65682080
127regulation of cholesterol homeostasis (GO:2000188)3.64514784
128short-chain fatty acid metabolic process (GO:0046459)3.64496016
129NAD biosynthetic process (GO:0009435)3.59257341
130exogenous drug catabolic process (GO:0042738)3.58774149
131acute inflammatory response (GO:0002526)3.57214019
132pyridine nucleotide biosynthetic process (GO:0019363)3.55584400
133nicotinamide nucleotide biosynthetic process (GO:0019359)3.55584400
134heme transport (GO:0015886)3.55286279
135sodium-independent organic anion transport (GO:0043252)3.53137721
136primary alcohol catabolic process (GO:0034310)3.49815049
137regulation of apoptotic cell clearance (GO:2000425)3.41600833
138aminoglycoside antibiotic metabolic process (GO:0030647)3.37878994
139regulation of acute inflammatory response (GO:0002673)3.35991601

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.38217308
2PPARA_22158963_ChIP-Seq_LIVER_Mouse7.19581923
3* EGR1_23403033_ChIP-Seq_LIVER_Mouse7.08072982
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.51605789
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.35381196
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.10784894
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.74856645
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.10044830
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.01585949
10TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.09065071
11ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.9887837
12TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.96301448
13HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.94756294
14FOXA2_19822575_ChIP-Seq_HepG2_Human1.60751532
15HTT_18923047_ChIP-ChIP_STHdh_Human1.59881987
16CLOCK_20551151_ChIP-Seq_293T_Human1.54198424
17GATA1_22025678_ChIP-Seq_K562_Human1.47219502
18TRIM28_21343339_ChIP-Seq_HEK293_Human1.46977445
19HNF4A_19822575_ChIP-Seq_HepG2_Human1.40429071
20THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.23556628
21RXRA_24833708_ChIP-Seq_LIVER_Mouse1.18976582
22STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.18051011
23STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.17283678
24ESR1_15608294_ChIP-ChIP_MCF-7_Human1.01626313
25ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.99869703
26IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.99653042
27PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.95634740
28TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.94667959
29MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.94371154
30SOX2_27498859_Chip-Seq_STOMACH_Mouse0.91881597
31TP53_18474530_ChIP-ChIP_U2OS_Human0.89244434
32HNFA_21074721_ChIP-Seq_CACO-2_Human0.87254983
33FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.84559855
34CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.84080704
35AUTS2_25519132_ChIP-Seq_293T-REX_Human0.83763407
36IRF8_22096565_ChIP-ChIP_GC-B_Human0.82515948
37PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.81078132
38ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.79047969
39PHF8_20622853_ChIP-Seq_HELA_Human0.78705750
40GATA4_25053715_ChIP-Seq_YYC3_Human0.78676407
41RARG_19884340_ChIP-ChIP_MEFs_Mouse0.78665359
42NFE2_27457419_Chip-Seq_LIVER_Mouse0.78353509
43KAP1_22055183_ChIP-Seq_ESCs_Mouse0.77301993
44ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.77018153
45BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.76389492
46SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.75658766
47PIAS1_25552417_ChIP-Seq_VCAP_Human0.73789852
48SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.72733349
49RARA_24833708_ChIP-Seq_LIVER_Mouse0.72689391
50GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.72644160
51CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.71622793
52* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.71401336
53EZH2_27294783_Chip-Seq_NPCs_Mouse0.70945516
54SOX2_20726797_ChIP-Seq_SW620_Human0.70813437
55NFYA_21822215_ChIP-Seq_K562_Human0.70201732
56AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.69445519
57NRF2_20460467_ChIP-Seq_MEFs_Mouse0.68899139
58NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.68899139
59SALL4_18804426_ChIP-ChIP_XEN_Mouse0.68621301
60IRF1_19129219_ChIP-ChIP_H3396_Human0.68501465
61ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.67524915
62ZNF263_19887448_ChIP-Seq_K562_Human0.66644670
63GATA6_21074721_ChIP-Seq_CACO-2_Human0.66032350
64ESR2_21235772_ChIP-Seq_MCF-7_Human0.64989058
65CDX2_19796622_ChIP-Seq_MESCs_Mouse0.63841669
66RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.62730978
67RARB_24833708_ChIP-Seq_LIVER_Mouse0.62291811
68SOX2_21211035_ChIP-Seq_LN229_Human0.59800189
69RAD21_21589869_ChIP-Seq_MESCs_Mouse0.59557233
70BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.58672082
71CRX_20693478_ChIP-Seq_RETINA_Mouse0.58451931
72CBX2_22325352_ChIP-Seq_293T-Rex_Human0.57990806
73CEBPB_22108803_ChIP-Seq_LS180_Human0.57364123
74NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.57134879
75SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.57062450
76NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.56994676
77TCF4_18268006_ChIP-ChIP_LS174T_Human0.56733236
78SUZ12_27294783_Chip-Seq_NPCs_Mouse0.55746760
79TAF15_26573619_Chip-Seq_HEK293_Human0.54960543
80EGR1_19032775_ChIP-ChIP_M12_Human0.54545724
81FOXA1_25552417_ChIP-Seq_VCAP_Human0.53490873
82AR_20517297_ChIP-Seq_VCAP_Human0.52792963
83FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.52634501
84PCGF2_27294783_Chip-Seq_NPCs_Mouse0.52604064
85OCT4_21477851_ChIP-Seq_ESCs_Mouse0.52434524
86ETV1_20927104_ChIP-Seq_GIST48_Human0.52376450
87FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.51443156
88POU3F2_20337985_ChIP-ChIP_501MEL_Human0.51378552
89PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.51177017
90MYC_19915707_ChIP-ChIP_AK7_Human0.50776734
91SMAD1_18555785_Chip-Seq_ESCs_Mouse0.50440662
92SPI1_20517297_ChIP-Seq_HL60_Human0.50200657
93OCT4_18555785_Chip-Seq_ESCs_Mouse0.50143885
94NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.49977253
95STAT3_1855785_ChIP-Seq_MESCs_Mouse0.49813413
96E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.49769086
97CBP_21632823_ChIP-Seq_H3396_Human0.49272793
98ESET_19884257_ChIP-Seq_ESCs_Mouse0.49141959
99GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.48916947
100RAC3_21632823_ChIP-Seq_H3396_Human0.48915279
101ER_23166858_ChIP-Seq_MCF-7_Human0.48564250
102ETV2_25802403_ChIP-Seq_MESCs_Mouse0.48456243
103STAT1_17558387_ChIP-Seq_HELA_Human0.47799930
104LXR_22292898_ChIP-Seq_THP-1_Human0.47709053
105PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.47071057
106P53_21459846_ChIP-Seq_SAOS-2_Human0.46483704
107ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.46397771
108NFYB_21822215_ChIP-Seq_K562_Human0.46366806
109PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.46355379
110CDX2_20551321_ChIP-Seq_CACO-2_Human0.45233702
111ESR1_21235772_ChIP-Seq_MCF-7_Human0.44365033
112PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.42644218
113FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.42634589
114PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.42380934
115FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.42154797
116CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.41939919
117FOXO3_23340844_ChIP-Seq_DLD1_Human0.41887578
118BCAT_22108803_ChIP-Seq_LS180_Human0.41863370
119ESR1_20079471_ChIP-ChIP_T-47D_Human0.40473964
120TAF2_19829295_ChIP-Seq_ESCs_Human0.40164628
121GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.39178165
122SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.38628554
123PPAR_26484153_Chip-Seq_NCI-H1993_Human0.38208430
124GATA2_19941826_ChIP-Seq_K562_Human0.37665749
125GATA1_19941826_ChIP-Seq_K562_Human0.37402216
126SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.37336685
127GATA1_19941827_ChIP-Seq_MEL_Mouse0.37310849
128GATA6_25053715_ChIP-Seq_YYC3_Human0.37295141
129STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.37084184
130ERG_21242973_ChIP-ChIP_JURKAT_Human0.36509402
131MYC_27129775_Chip-Seq_CORNEA_Mouse0.36299080
132BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.35246199
133NCOR_22424771_ChIP-Seq_293T_Human0.35108150
134FOXH1_21741376_ChIP-Seq_EPCs_Human0.35054822
135LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.34975039
136SPI1_26923725_Chip-Seq_HPCs_Mouse0.34545825
137CDX2_22108803_ChIP-Seq_LS180_Human0.34297865

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.35345172
2MP0005360_urolithiasis7.52777920
3MP0005085_abnormal_gallbladder_physiolo6.55539049
4MP0005365_abnormal_bile_salt6.25678536
5MP0008875_abnormal_xenobiotic_pharmacok5.18426693
6MP0003806_abnormal_nucleotide_metabolis4.29851624
7MP0003252_abnormal_bile_duct4.01032719
8MP0010329_abnormal_lipoprotein_level3.54600342
9MP0009840_abnormal_foam_cell3.17669574
10MP0005083_abnormal_biliary_tract3.02567447
11MP0003195_calcinosis2.78343430
12MP0005332_abnormal_amino_acid2.76215767
13MP0001666_abnormal_nutrient_absorption2.60799805
14MP0003191_abnormal_cellular_cholesterol2.21561549
15MP0000609_abnormal_liver_physiology2.15992981
16MP0004019_abnormal_vitamin_homeostasis2.09720438
17MP0002118_abnormal_lipid_homeostasis2.09276439
18MP0002138_abnormal_hepatobiliary_system2.01321206
19MP0003868_abnormal_feces_composition1.99086817
20MP0005319_abnormal_enzyme/_coenzyme1.83729997
21MP0001764_abnormal_homeostasis1.68931218
22MP0009697_abnormal_copulation1.61998384
23MP0005584_abnormal_enzyme/coenzyme_acti1.55691319
24MP0005451_abnormal_body_composition1.41476331
25MP0003011_delayed_dark_adaptation1.34426364
26MP0003186_abnormal_redox_activity1.25692059
27MP0003656_abnormal_erythrocyte_physiolo1.21614502
28MP0009643_abnormal_urine_homeostasis1.21136700
29MP0000598_abnormal_liver_morphology1.17658557
30MP0005647_abnormal_sex_gland1.15833056
31MP0003705_abnormal_hypodermis_morpholog1.12910608
32MP0009764_decreased_sensitivity_to1.06445213
33MP0000604_amyloidosis1.02812575
34MP0009763_increased_sensitivity_to1.01534722
35MP0002254_reproductive_system_inflammat1.00944661
36MP0010368_abnormal_lymphatic_system0.94259314
37MP0005636_abnormal_mineral_homeostasis0.89927039
38MP0008469_abnormal_protein_level0.88714015
39MP0005670_abnormal_white_adipose0.87108931
40MP0009642_abnormal_blood_homeostasis0.85799231
41MP0005408_hypopigmentation0.84810266
42MP0005023_abnormal_wound_healing0.82491889
43MP0006036_abnormal_mitochondrial_physio0.80585150
44MP0005376_homeostasis/metabolism_phenot0.79975512
45MP0001915_intracranial_hemorrhage0.79812238
46MP0005084_abnormal_gallbladder_morpholo0.78861392
47MP0009765_abnormal_xenobiotic_induced0.78752161
48MP0002876_abnormal_thyroid_physiology0.76675965
49MP0002282_abnormal_trachea_morphology0.76011320
50MP0002078_abnormal_glucose_homeostasis0.75984688
51MP0005220_abnormal_exocrine_pancreas0.73407943
52MP0004130_abnormal_muscle_cell0.70907202
53MP0002971_abnormal_brown_adipose0.70718333
54MP0005334_abnormal_fat_pad0.68344562
55MP0003690_abnormal_glial_cell0.68151746
56MP0005535_abnormal_body_temperature0.68123128
57MP0009785_altered_susceptibility_to0.66982754
58MP0005266_abnormal_metabolism0.65928211
59MP0001661_extended_life_span0.64323871
60MP0009053_abnormal_anal_canal0.63364418
61MP0005187_abnormal_penis_morphology0.61688041
62MP0003329_amyloid_beta_deposits0.60988970
63MP0000639_abnormal_adrenal_gland0.59082637
64MP0003879_abnormal_hair_cell0.58023763
65MP0006035_abnormal_mitochondrial_morpho0.57834157
66MP0001756_abnormal_urination0.56141962
67MP0005448_abnormal_energy_balance0.52518531
68MP0005464_abnormal_platelet_physiology0.49518503
69MP0002928_abnormal_bile_duct0.48915788
70MP0004381_abnormal_hair_follicle0.48139359
71MP0002822_catalepsy0.46990975
72MP0008874_decreased_physiological_sensi0.46959329
73MP0005164_abnormal_response_to0.46248315
74MP0005395_other_phenotype0.45829295
75MP0003638_abnormal_response/metabolism_0.45258134
76MP0008873_increased_physiological_sensi0.45142543
77MP0005058_abnormal_lysosome_morphology0.45065005
78MP0002249_abnormal_larynx_morphology0.44964723
79MP0003718_maternal_effect0.44282663
80MP0004782_abnormal_surfactant_physiolog0.43654199
81MP0002136_abnormal_kidney_physiology0.43113927
82MP0003724_increased_susceptibility_to0.42622735
83MP0002837_dystrophic_cardiac_calcinosis0.40613558
84MP0003436_decreased_susceptibility_to0.40373333
85MP0005248_abnormal_Harderian_gland0.39748021
86MP0000579_abnormal_nail_morphology0.39670345
87MP0005166_decreased_susceptibility_to0.39430323
88MP0003953_abnormal_hormone_level0.39098796
89MP0003075_altered_response_to0.39017457
90MP0001851_eye_inflammation0.38530352
91MP0005666_abnormal_adipose_tissue0.38026953
92MP0008872_abnormal_physiological_respon0.37901894
93MP0009384_cardiac_valve_regurgitation0.37765323
94MP0009672_abnormal_birth_weight0.35194579
95MP0000467_abnormal_esophagus_morphology0.33811331
96MP0002332_abnormal_exercise_endurance0.33195767
97MP0002796_impaired_skin_barrier0.32639150
98MP0000230_abnormal_systemic_arterial0.32119831
99MP0009115_abnormal_fat_cell0.31697398
100MP0006082_CNS_inflammation0.30381055
101MP0001243_abnormal_dermal_layer0.29890387
102MP0001853_heart_inflammation0.29824322
103MP0000249_abnormal_blood_vessel0.29691988
104MP0002970_abnormal_white_adipose0.29206113
105MP0002168_other_aberrant_phenotype0.28872775
106MP0001881_abnormal_mammary_gland0.28539309
107MP0004883_abnormal_blood_vessel0.27486048
108MP0000920_abnormal_myelination0.27320298
109MP0001845_abnormal_inflammatory_respons0.26871382
110MP0005197_abnormal_uvea_morphology0.26455617
111MP0002060_abnormal_skin_morphology0.25393983
112MP0002090_abnormal_vision0.24285821
113MP0002419_abnormal_innate_immunity0.24151175
114MP0000427_abnormal_hair_cycle0.24088482
115MP0004272_abnormal_basement_membrane0.23858449
116MP0002132_abnormal_respiratory_system0.23066814
117MP0003959_abnormal_lean_body0.22805334
118MP0000858_altered_metastatic_potential0.21541171
119MP0002128_abnormal_blood_circulation0.21145499
120MP0003300_gastrointestinal_ulcer0.20634323
121MP0001545_abnormal_hematopoietic_system0.20134384
122MP0005397_hematopoietic_system_phenotyp0.20134384

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)7.46474186
2Abnormality of aromatic amino acid family metabolism (HP:0004338)7.45198243
3Deep venous thrombosis (HP:0002625)7.40274854
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.84130441
5Prolonged partial thromboplastin time (HP:0003645)6.60900200
6Hypobetalipoproteinemia (HP:0003563)6.46582025
7Xanthomatosis (HP:0000991)6.30522311
8Complement deficiency (HP:0004431)5.64803501
9Hyperlipoproteinemia (HP:0010980)5.56531722
10Hypolipoproteinemia (HP:0010981)4.77469871
11Joint hemorrhage (HP:0005261)4.74482083
12Epidermoid cyst (HP:0200040)4.67649695
13Hyperammonemia (HP:0001987)4.62866764
14Abnormality of the common coagulation pathway (HP:0010990)4.45286463
15Hyperglycinemia (HP:0002154)4.42956279
16Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.38797029
17Abnormality of methionine metabolism (HP:0010901)4.37323345
18Abnormality of sulfur amino acid metabolism (HP:0004339)4.30033271
19Ketosis (HP:0001946)4.24365381
20Fat malabsorption (HP:0002630)4.22820990
21Abnormality of aspartate family amino acid metabolism (HP:0010899)4.19313332
22Abnormality of glutamine family amino acid metabolism (HP:0010902)4.17102957
23Hypoalphalipoproteinemia (HP:0003233)4.12466656
24Abnormality of complement system (HP:0005339)4.11955257
25Abnormality of pyrimidine metabolism (HP:0004353)3.94326733
26Hyperglycinuria (HP:0003108)3.87535239
27Abnormality of glycine metabolism (HP:0010895)3.87450690
28Abnormality of serine family amino acid metabolism (HP:0010894)3.87450690
29Conjugated hyperbilirubinemia (HP:0002908)3.81213588
30Hypoglycemic coma (HP:0001325)3.81206483
31Abnormality of the intrinsic pathway (HP:0010989)3.78515406
32Hypercholesterolemia (HP:0003124)3.63630836
33Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.38916968
34Hyperbilirubinemia (HP:0002904)3.33646194
35Abnormality of fatty-acid metabolism (HP:0004359)3.31367428
36Steatorrhea (HP:0002570)3.21768766
37Abnormality of serum amino acid levels (HP:0003112)3.11386681
38Delayed CNS myelination (HP:0002188)3.08625647
39Abnormality of nucleobase metabolism (HP:0010932)3.07863106
40Spontaneous abortion (HP:0005268)3.01332694
41Ketoacidosis (HP:0001993)2.98226886
42Hepatocellular carcinoma (HP:0001402)2.97237762
43Myocardial infarction (HP:0001658)2.95913478
44Hypochromic microcytic anemia (HP:0004840)2.95848879
45Skin nodule (HP:0200036)2.89479100
46Systemic lupus erythematosus (HP:0002725)2.82114768
47Metabolic acidosis (HP:0001942)2.72759729
48Abnormality of purine metabolism (HP:0004352)2.64631293
49Lethargy (HP:0001254)2.61019376
50Purpura (HP:0000979)2.58593776
51Acanthocytosis (HP:0001927)2.56724581
52Osteomalacia (HP:0002749)2.54912025
53Recurrent gram-negative bacterial infections (HP:0005420)2.53057272
54Abnormality of dicarboxylic acid metabolism (HP:0010995)2.52674271
55Dicarboxylic aciduria (HP:0003215)2.52674271
56Spastic diplegia (HP:0001264)2.52023670
57Vascular calcification (HP:0004934)2.52015120
58Abnormal gallbladder morphology (HP:0012437)2.47168122
59Cerebral edema (HP:0002181)2.46653663
60Hypoglycemic seizures (HP:0002173)2.46034426
61Mitral stenosis (HP:0001718)2.44142266
62Gout (HP:0001997)2.40494527
63Neonatal onset (HP:0003623)2.40467943
64Cholelithiasis (HP:0001081)2.40421792
65Glomerulonephritis (HP:0000099)2.39780864
66Irritability (HP:0000737)2.37261702
67Cholecystitis (HP:0001082)2.34825188
68Abnormal gallbladder physiology (HP:0012438)2.34825188
69Fair hair (HP:0002286)2.34266214
70Pulmonary embolism (HP:0002204)2.32086668
71Neonatal hypoglycemia (HP:0001998)2.25689543
72Cardiovascular calcification (HP:0011915)2.23231583
73Amyloidosis (HP:0011034)2.21596958
74Malnutrition (HP:0004395)2.21279164
75Gingival bleeding (HP:0000225)2.18394033
76Sensorimotor neuropathy (HP:0007141)2.17705950
77Esophageal varix (HP:0002040)2.15622727
78Brushfield spots (HP:0001088)2.14071375
79Pancreatitis (HP:0001733)2.11986406
80Late onset (HP:0003584)2.09617240
81Enlarged kidneys (HP:0000105)2.09424541
82Menorrhagia (HP:0000132)2.08892267
83Hyperphosphaturia (HP:0003109)2.05577111
84Thrombophlebitis (HP:0004418)2.05061585
85Vomiting (HP:0002013)2.04411216
86Joint swelling (HP:0001386)2.04091260
87Reduced antithrombin III activity (HP:0001976)2.03193228
88Opisthotonus (HP:0002179)2.02499983
89Abnormality of the gallbladder (HP:0005264)2.01020511
90Hyperinsulinemic hypoglycemia (HP:0000825)1.99556164
91Poikilocytosis (HP:0004447)1.98244787
92Generalized aminoaciduria (HP:0002909)1.97787771
93Elevated alkaline phosphatase (HP:0003155)1.95666127
94Hemorrhage of the eye (HP:0011885)1.95558618
95Rickets (HP:0002748)1.93360438
96Abnormality of iron homeostasis (HP:0011031)1.91007064
97Arthropathy (HP:0003040)1.89719877
98Increased mean platelet volume (HP:0011877)1.88270765
99Abnormal cartilage morphology (HP:0002763)1.88180233
100Abnormality of transition element cation homeostasis (HP:0011030)1.87494612
101Renal cortical cysts (HP:0000803)1.86587443
102Abnormality of urine glucose concentration (HP:0011016)1.85673466
103Glycosuria (HP:0003076)1.85673466
104Abnormal enzyme/coenzyme activity (HP:0012379)1.83067744
105Alkalosis (HP:0001948)1.82723532
106Elevated hepatic transaminases (HP:0002910)1.81909467
107Hypophosphatemic rickets (HP:0004912)1.81109018
108Status epilepticus (HP:0002133)1.80909860
109Hydroxyprolinuria (HP:0003080)1.78711724
110Abnormality of proline metabolism (HP:0010907)1.78711724
111Hyperglycemia (HP:0003074)1.78249282
112Increased serum ferritin (HP:0003281)1.77466133
113Abnormality of vitamin metabolism (HP:0100508)1.76992118
114Abnormality of the Achilles tendon (HP:0005109)1.76933348
115Epistaxis (HP:0000421)1.76521318
116Abnormality of alkaline phosphatase activity (HP:0004379)1.76053198
117Bifid scrotum (HP:0000048)1.74825214
118Gangrene (HP:0100758)1.74112241
119Cerebral palsy (HP:0100021)1.73528627
120Nephritis (HP:0000123)1.70560915
121Abnormal platelet volume (HP:0011876)1.70434713
122Abnormal delivery (HP:0001787)1.70318444
123Abnormal platelet function (HP:0011869)1.66046703
124Impaired platelet aggregation (HP:0003540)1.66046703
125Abnormal urine phosphate concentration (HP:0012599)1.63891739
126Generalized hypopigmentation of hair (HP:0011358)1.61154138
127Periodontitis (HP:0000704)1.54308597

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.06340120
2FGFR44.52681579
3SIK14.44953712
4ERN14.35047643
5ERBB43.24353841
6TAOK33.17558943
7INSRR3.08982150
8PRPF4B2.42819444
9MAP2K42.42364412
10MST1R2.10962163
11PKN22.10424093
12MAPK111.98427049
13PIK3CG1.89386776
14FLT31.89161683
15LATS11.72300713
16NTRK31.68145835
17FER1.66931946
18TYK21.65661588
19TRIB31.60369126
20MAP3K121.57237321
21ABL21.53229286
22NLK1.53143210
23DAPK21.52475290
24FRK1.49572191
25FGFR21.49106837
26PTK61.44058049
27NEK91.43528840
28MAP3K21.39732655
29MYLK1.39106270
30BLK1.38909142
31CAMKK21.28388522
32MAP3K71.27041061
33JAK21.25478384
34KDR1.24250527
35PINK11.13999767
36PRKAA21.13313476
37ERBB21.11133609
38MAP3K141.08800719
39ZAP701.06105143
40MAP3K101.05189506
41GRK61.04411587
42TBK11.04280392
43JAK11.03939687
44MAP2K31.01970530
45MAPK41.00550476
46KSR20.95854933
47SCYL20.94343903
48PRKCZ0.93972340
49MAPK150.93120981
50STK38L0.86941945
51MET0.85160692
52EPHB10.82800471
53MAPK120.82249543
54CDK60.81333926
55MAP3K30.79895324
56PDGFRA0.78600241
57EPHA30.78072025
58CAMK2G0.77533227
59PRKACG0.75952872
60TNK20.75559282
61TIE10.73923993
62MAP3K110.69094999
63CSK0.68457469
64MAP2K60.67015833
65SGK30.66697975
66CAMK1D0.66470058
67GSK3A0.65615212
68PRKAA10.65484223
69IRAK30.65472758
70DYRK1B0.65189740
71PRKG10.63531235
72MAPK70.62653710
73FGFR30.61045387
74RIPK10.59332056
75CSF1R0.57432220
76PRKACA0.57283372
77JAK30.56751733
78IKBKE0.54332306
79KIT0.53914647
80TGFBR20.53634636
81PRKCQ0.53032918
82PKN10.52623020
83EPHA40.52584781
84PDPK10.52539425
85PTK20.51529496
86CSNK1G10.51368526
87SGK20.50102317
88MAP3K130.47747748
89MAP3K50.45863251
90SRC0.44537920
91GRK10.44211511
92RET0.42429794
93MAP2K10.42355315
94ACVR1B0.42088504
95TAOK20.41871670
96PRKCB0.41177841
97PRKCG0.40966367
98CDK40.38740482
99ICK0.38158184
100MAP3K60.36935813
101PDK20.36693564
102EGFR0.36367506
103SGK2230.34157891
104SGK4940.34157891
105MTOR0.34140867
106CSNK1D0.33919864
107PBK0.32821518
108RPS6KA30.32748073
109PIK3CA0.32330585
110PDK10.32302480
111PRKACB0.32009260
112CSNK1G20.31960930
113CAMKK10.31304044
114CAMK40.31228837
115IRAK20.29706812
116LATS20.29261390
117IRAK10.29012877
118EIF2AK10.28067220
119CDC42BPA0.27847256
120CSNK1G30.27572091
121ARAF0.27286815
122PRKCA0.26746376
123MAP3K10.24419304
124ABL10.23948890
125* IGF1R0.22691178
126PAK30.22536536
127CAMK1G0.22252996
128PDK40.20949938
129PDK30.20949938

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.65403596
2Nitrogen metabolism_Homo sapiens_hsa009103.61745166
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.46469463
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.33486518
5Arginine biosynthesis_Homo sapiens_hsa002203.11886120
6Complement and coagulation cascades_Homo sapiens_hsa046102.77333048
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.63984433
8* Tryptophan metabolism_Homo sapiens_hsa003802.61237500
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.58274280
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.55170623
11Fatty acid degradation_Homo sapiens_hsa000712.47398612
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.37070529
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.23925437
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.15755075
15Butanoate metabolism_Homo sapiens_hsa006502.12763433
16Peroxisome_Homo sapiens_hsa041462.09386038
17Steroid hormone biosynthesis_Homo sapiens_hsa001401.96440158
18Chemical carcinogenesis_Homo sapiens_hsa052041.96022695
19Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.94243573
20Propanoate metabolism_Homo sapiens_hsa006401.90608301
21Caffeine metabolism_Homo sapiens_hsa002321.90164995
22Histidine metabolism_Homo sapiens_hsa003401.89569662
23PPAR signaling pathway_Homo sapiens_hsa033201.85699016
24Drug metabolism - other enzymes_Homo sapiens_hsa009831.77595012
25Fatty acid metabolism_Homo sapiens_hsa012121.76534874
26Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.76332890
27Staphylococcus aureus infection_Homo sapiens_hsa051501.73444699
28Retinol metabolism_Homo sapiens_hsa008301.73249663
29beta-Alanine metabolism_Homo sapiens_hsa004101.70326962
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.67306995
31Phenylalanine metabolism_Homo sapiens_hsa003601.58443421
32Selenocompound metabolism_Homo sapiens_hsa004501.57754294
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.52643599
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.50602018
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.50146720
36Bile secretion_Homo sapiens_hsa049761.48560019
37Tyrosine metabolism_Homo sapiens_hsa003501.45614339
38Cysteine and methionine metabolism_Homo sapiens_hsa002701.34953747
39Pyruvate metabolism_Homo sapiens_hsa006201.33908135
40Sulfur metabolism_Homo sapiens_hsa009201.32392544
41Fatty acid elongation_Homo sapiens_hsa000621.30107673
42Starch and sucrose metabolism_Homo sapiens_hsa005001.28649951
43Biosynthesis of amino acids_Homo sapiens_hsa012301.21308725
44ABC transporters_Homo sapiens_hsa020101.20471894
45Folate biosynthesis_Homo sapiens_hsa007901.20285447
46Steroid biosynthesis_Homo sapiens_hsa001001.15947281
47Fat digestion and absorption_Homo sapiens_hsa049751.12972781
48Carbon metabolism_Homo sapiens_hsa012001.10907051
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.06772763
50Maturity onset diabetes of the young_Homo sapiens_hsa049501.00413844
51Vitamin B6 metabolism_Homo sapiens_hsa007500.99180800
52Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.95047528
53Arginine and proline metabolism_Homo sapiens_hsa003300.94353913
54Cyanoamino acid metabolism_Homo sapiens_hsa004600.92500959
55Sulfur relay system_Homo sapiens_hsa041220.92091585
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.87881371
57Vitamin digestion and absorption_Homo sapiens_hsa049770.81864566
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.81493384
59Lysine degradation_Homo sapiens_hsa003100.80976865
60One carbon pool by folate_Homo sapiens_hsa006700.73905243
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68394476
62Glutathione metabolism_Homo sapiens_hsa004800.65535950
63Glycerolipid metabolism_Homo sapiens_hsa005610.65492731
64Pentose phosphate pathway_Homo sapiens_hsa000300.54606489
65Fatty acid biosynthesis_Homo sapiens_hsa000610.52037219
66Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.46174893
67* Metabolic pathways_Homo sapiens_hsa011000.44803380
68Prion diseases_Homo sapiens_hsa050200.43114060
69Pertussis_Homo sapiens_hsa051330.42470624
70Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.41589010
71Galactose metabolism_Homo sapiens_hsa000520.23556900
72alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.23252234
73Insulin resistance_Homo sapiens_hsa049310.22596748
74Linoleic acid metabolism_Homo sapiens_hsa005910.21967036
75Fructose and mannose metabolism_Homo sapiens_hsa000510.21680721
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.21453176
77Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.17556486
78Glycerophospholipid metabolism_Homo sapiens_hsa005640.15333425
79Glucagon signaling pathway_Homo sapiens_hsa049220.10293914
80Other glycan degradation_Homo sapiens_hsa005110.05380012
81AMPK signaling pathway_Homo sapiens_hsa041520.01563698
82Type II diabetes mellitus_Homo sapiens_hsa04930-0.2646614
83N-Glycan biosynthesis_Homo sapiens_hsa00510-0.2546804
84Lysosome_Homo sapiens_hsa04142-0.2532282
85Bladder cancer_Homo sapiens_hsa05219-0.2508007
86Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2394459
87Protein digestion and absorption_Homo sapiens_hsa04974-0.2375644
88Vascular smooth muscle contraction_Homo sapiens_hsa04270-0.2353591
89Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2350090
90Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.2242619
91Amoebiasis_Homo sapiens_hsa05146-0.2159356
92Renin-angiotensin system_Homo sapiens_hsa04614-0.2115903
93Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1979845
94Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1954397
95Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1938064
96Hepatitis C_Homo sapiens_hsa05160-0.1795645
97Sphingolipid metabolism_Homo sapiens_hsa00600-0.1772923
98Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1720968
99Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1677509
100African trypanosomiasis_Homo sapiens_hsa05143-0.1521673
101Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1518335
102Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1302351
103Regulation of autophagy_Homo sapiens_hsa04140-0.1231432
104Insulin signaling pathway_Homo sapiens_hsa04910-0.1047334
105Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0985376
106Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0825448
107Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0624440
108Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0562488
109Mineral absorption_Homo sapiens_hsa04978-0.0356217
110Serotonergic synapse_Homo sapiens_hsa04726-0.0239127

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