TDP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. This protein may also remove glycolate from single-stranded DNA containing 3-prime phosphoglycolate, suggesting a role in repair of free-radical mediated DNA double-strand breaks. This gene is a member of the phospholipase D family and contains two PLD phosphodiesterase domains. Mutations in this gene are associated with the disease spinocerebellar ataxia with axonal neuropathy (SCAN1). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand elongation involved in DNA replication (GO:0006271)5.13817048
2DNA strand elongation (GO:0022616)4.88016177
3telomere maintenance via semi-conservative replication (GO:0032201)4.86113156
4DNA unwinding involved in DNA replication (GO:0006268)4.60298600
5DNA replication initiation (GO:0006270)4.57795986
6telomere maintenance via recombination (GO:0000722)4.33586943
7protein localization to kinetochore (GO:0034501)4.14236079
8mitotic recombination (GO:0006312)4.12885429
9mitotic metaphase plate congression (GO:0007080)4.09790689
10CENP-A containing nucleosome assembly (GO:0034080)4.02305573
11mitotic nuclear envelope disassembly (GO:0007077)4.01883368
12chromatin remodeling at centromere (GO:0031055)4.00997509
13DNA deamination (GO:0045006)3.95668234
14nucleobase biosynthetic process (GO:0046112)3.95319061
15DNA replication checkpoint (GO:0000076)3.94710689
16nucleotide-excision repair, DNA gap filling (GO:0006297)3.93091912
17telomere maintenance via telomere lengthening (GO:0010833)3.90556115
18protein localization to chromosome, centromeric region (GO:0071459)3.88111433
19mitotic sister chromatid cohesion (GO:0007064)3.85607077
20attachment of spindle microtubules to kinetochore (GO:0008608)3.84798007
21mitotic sister chromatid segregation (GO:0000070)3.84193379
22DNA replication-dependent nucleosome assembly (GO:0006335)3.82413276
23DNA replication-dependent nucleosome organization (GO:0034723)3.82413276
24ribosomal small subunit assembly (GO:0000028)3.81334542
25DNA ligation (GO:0006266)3.80528108
26metaphase plate congression (GO:0051310)3.75959015
27formation of translation preinitiation complex (GO:0001731)3.74503155
28establishment of chromosome localization (GO:0051303)3.71288682
29DNA replication-independent nucleosome organization (GO:0034724)3.68406424
30DNA replication-independent nucleosome assembly (GO:0006336)3.68406424
31nuclear envelope disassembly (GO:0051081)3.67418482
32membrane disassembly (GO:0030397)3.67418482
33mitotic chromosome condensation (GO:0007076)3.65708595
34kinetochore organization (GO:0051383)3.63545236
35IMP biosynthetic process (GO:0006188)3.62168789
36regulation of mitotic spindle checkpoint (GO:1903504)3.60644227
37regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.60644227
38DNA double-strand break processing (GO:0000729)3.60312106
39meiotic chromosome segregation (GO:0045132)3.57200560
40purine nucleobase biosynthetic process (GO:0009113)3.55123588
41protein K6-linked ubiquitination (GO:0085020)3.54518840
42histone arginine methylation (GO:0034969)3.53070259
43histone exchange (GO:0043486)3.50947120
44regulation of centriole replication (GO:0046599)3.48567090
45sister chromatid segregation (GO:0000819)3.46201404
46folic acid-containing compound biosynthetic process (GO:0009396)3.45692418
47positive regulation of chromosome segregation (GO:0051984)3.43821643
48negative regulation of DNA-dependent DNA replication (GO:2000104)3.38611758
49kinetochore assembly (GO:0051382)3.38572792
50pseudouridine synthesis (GO:0001522)3.38563594
51maturation of SSU-rRNA (GO:0030490)3.38369202
52somatic diversification of immune receptors via somatic mutation (GO:0002566)3.34330878
53somatic hypermutation of immunoglobulin genes (GO:0016446)3.34330878
54establishment of integrated proviral latency (GO:0075713)3.33977646
55nuclear pore organization (GO:0006999)3.33469442
56regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.30445130
57deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.25639047
58establishment of viral latency (GO:0019043)3.25626424
59regulation of spindle organization (GO:0090224)3.25567262
60histone H2A acetylation (GO:0043968)3.24892828
61cullin deneddylation (GO:0010388)3.23204610
62mismatch repair (GO:0006298)3.23164448
63spliceosomal snRNP assembly (GO:0000387)3.19228828
64double-strand break repair via nonhomologous end joining (GO:0006303)3.19076650
65non-recombinational repair (GO:0000726)3.19076650
66transcription-coupled nucleotide-excision repair (GO:0006283)3.18176748
67replication fork processing (GO:0031297)3.17961494
68IMP metabolic process (GO:0046040)3.17106491
69anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.16826357
70negative regulation of chromosome segregation (GO:0051985)3.16547237
71regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.16451566
72positive regulation of histone H3-K4 methylation (GO:0051571)3.16265933
73protein deneddylation (GO:0000338)3.15822492
74negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.15709914
75negative regulation of sister chromatid segregation (GO:0033046)3.15709914
76negative regulation of mitotic sister chromatid separation (GO:2000816)3.15709914
77negative regulation of mitotic sister chromatid segregation (GO:0033048)3.15709914
78telomere maintenance (GO:0000723)3.14216651
79telomere organization (GO:0032200)3.13901221
80regulation of chromosome segregation (GO:0051983)3.12963885
81positive regulation of mitotic sister chromatid separation (GO:1901970)3.12892042
82positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.12892042
83positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.12892042
84ribosome assembly (GO:0042255)3.12856141
85nuclear pore complex assembly (GO:0051292)3.12550182
86base-excision repair (GO:0006284)3.11705453
87negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.10437627
88viral mRNA export from host cell nucleus (GO:0046784)3.10012760
89rRNA modification (GO:0000154)3.09633558
90spindle checkpoint (GO:0031577)3.09352854
91spindle assembly checkpoint (GO:0071173)3.08024037
92pore complex assembly (GO:0046931)3.07626550
93mitotic spindle assembly checkpoint (GO:0007094)3.06255558
94ribosome biogenesis (GO:0042254)3.06201262
95DNA catabolic process, exonucleolytic (GO:0000738)3.05057572
96synapsis (GO:0007129)3.04919708
97regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.04795363
98negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.04135446
99maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.99701659
100DNA duplex unwinding (GO:0032508)2.98823659
101chromosome segregation (GO:0007059)2.98172517
102translesion synthesis (GO:0019985)2.98014087
103negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.97806373
104negative regulation of ligase activity (GO:0051352)2.97806373
105DNA geometric change (GO:0032392)2.97634530
106proteasome assembly (GO:0043248)2.97585109
107mitotic spindle checkpoint (GO:0071174)2.97363408
108regulation of spindle checkpoint (GO:0090231)2.97127241
109DNA topological change (GO:0006265)2.96783945
110rRNA methylation (GO:0031167)2.96684535
111DNA damage response, detection of DNA damage (GO:0042769)2.96568180
112postreplication repair (GO:0006301)2.96052430
113regulation of mitotic metaphase/anaphase transition (GO:0030071)2.94599714
114regulation of meiosis I (GO:0060631)2.94475980
115chromatin assembly or disassembly (GO:0006333)2.92483609
116positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.92316289
117spliceosomal complex assembly (GO:0000245)2.91600204
118ribonucleoprotein complex biogenesis (GO:0022613)2.91210693
119regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.91005451
120regulation of centrosome cycle (GO:0046605)2.90707148
121chromosome condensation (GO:0030261)2.88198197
122mitotic cell cycle (GO:0000278)2.87551985
123protein localization to chromosome (GO:0034502)2.87353708
124exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.85476102
125rRNA processing (GO:0006364)2.84818922
126ATP-dependent chromatin remodeling (GO:0043044)2.84438308
127regulation of mitotic sister chromatid separation (GO:0010965)2.84262136
128regulation of mitotic sister chromatid segregation (GO:0033047)2.84262136
129regulation of sister chromatid segregation (GO:0033045)2.84262136
130DNA conformation change (GO:0071103)2.83906880

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.93566843
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.61821729
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.23715675
4E2F4_17652178_ChIP-ChIP_JURKAT_Human4.01994982
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.80041048
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.47622082
7MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.38692740
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.26938255
9EST1_17652178_ChIP-ChIP_JURKAT_Human3.06306255
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.86966302
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.86398953
12* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.79947440
13* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.79865401
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.78723238
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.78616294
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.76646523
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.54686716
18XRN2_22483619_ChIP-Seq_HELA_Human2.39024326
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.38737527
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.32293520
21ELF1_17652178_ChIP-ChIP_JURKAT_Human2.31394533
22NELFA_20434984_ChIP-Seq_ESCs_Mouse2.28115095
23* VDR_23849224_ChIP-Seq_CD4+_Human2.21235840
24SALL1_21062744_ChIP-ChIP_HESCs_Human2.17502715
25* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.04326447
26E2F1_21310950_ChIP-Seq_MCF-7_Human2.04143008
27* FOXP3_21729870_ChIP-Seq_TREG_Human2.03985060
28AR_21909140_ChIP-Seq_LNCAP_Human2.02673984
29E2F1_18555785_ChIP-Seq_MESCs_Mouse1.96746693
30DCP1A_22483619_ChIP-Seq_HELA_Human1.95553466
31GABP_19822575_ChIP-Seq_HepG2_Human1.95028485
32THAP11_20581084_ChIP-Seq_MESCs_Mouse1.94135280
33MYCN_18555785_ChIP-Seq_MESCs_Mouse1.90778166
34* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.90448513
35MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.88561358
36TTF2_22483619_ChIP-Seq_HELA_Human1.86284130
37CIITA_25753668_ChIP-Seq_RAJI_Human1.84492949
38RBPJ_22232070_ChIP-Seq_NCS_Mouse1.81804665
39SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.78604758
40PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.77159205
41POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.71511861
42KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.70900697
43YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.69662392
44NANOG_18555785_ChIP-Seq_MESCs_Mouse1.66622888
45TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.64796968
46ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.63902715
47MYC_22102868_ChIP-Seq_BL_Human1.63060141
48SRF_21415370_ChIP-Seq_HL-1_Mouse1.58684132
49ZNF274_21170338_ChIP-Seq_K562_Hela1.58547375
50SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.58155002
51ELK1_19687146_ChIP-ChIP_HELA_Human1.57401859
52YY1_21170310_ChIP-Seq_MESCs_Mouse1.56328562
53FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.55432124
54* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.51441204
55EGR1_19374776_ChIP-ChIP_THP-1_Human1.50697185
56HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.49288773
57* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.47765373
58ZFX_18555785_ChIP-Seq_MESCs_Mouse1.46660318
59EWS_26573619_Chip-Seq_HEK293_Human1.44261603
60KDM5A_27292631_Chip-Seq_BREAST_Human1.40271311
61* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.39832039
62ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.37500176
63CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.33784133
64* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.27200311
65PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.26860038
66* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.25456573
67ERG_20887958_ChIP-Seq_HPC-7_Mouse1.24378740
68POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.19444730
69SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.17509439
70SOX2_16153702_ChIP-ChIP_HESCs_Human1.17370518
71FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.15991283
72PADI4_21655091_ChIP-ChIP_MCF-7_Human1.15284965
73NANOG_16153702_ChIP-ChIP_HESCs_Human1.14790022
74E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.13262739
75SOX2_18555785_ChIP-Seq_MESCs_Mouse1.12190046
76DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.11733998
77MYC_18940864_ChIP-ChIP_HL60_Human1.10174330
78CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.09402850
79IRF1_19129219_ChIP-ChIP_H3396_Human1.08350767
80TFEB_21752829_ChIP-Seq_HELA_Human1.04256839
81POU5F1_16153702_ChIP-ChIP_HESCs_Human1.03676866
82TP63_19390658_ChIP-ChIP_HaCaT_Human1.01518224
83POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.01496474
84DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.01192486
85CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.00864575
86KLF4_18555785_ChIP-Seq_MESCs_Mouse0.99948934
87FLI1_27457419_Chip-Seq_LIVER_Mouse0.99873583
88STAT3_1855785_ChIP-Seq_MESCs_Mouse0.99060424
89GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.98955866
90FUS_26573619_Chip-Seq_HEK293_Human0.97747202
91CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.97695277
92ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.97384432
93VDR_21846776_ChIP-Seq_THP-1_Human0.95994404
94SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.95502594
95NOTCH1_21737748_ChIP-Seq_TLL_Human0.94310257
96PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.94178473
97BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.91769029
98* SPI1_23547873_ChIP-Seq_NB4_Human0.89827659
99KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.86064709
100TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.85419237
101SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.85416842
102CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.84839781
103NANOG_21062744_ChIP-ChIP_HESCs_Human0.82401497
104CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.79440569
105BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.79317090
106IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.79283034
107CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.78931365
108* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76474961
109KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.74580204
110KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.74580204
111KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.74580204
112SOX17_20123909_ChIP-Seq_XEN_Mouse0.72890704
113TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.72086987
114ELK1_22589737_ChIP-Seq_MCF10A_Human0.70633301
115CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.69203747
116VDR_22108803_ChIP-Seq_LS180_Human0.68781176
117HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.68701465
118TBX5_21415370_ChIP-Seq_HL-1_Mouse0.68266108
119PCGF2_27294783_Chip-Seq_ESCs_Mouse0.67560323
120KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.67553701
121SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.67296725
122NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.67103424
123HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.62838124

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability5.35009647
2MP0003693_abnormal_embryo_hatching5.19031117
3MP0003111_abnormal_nucleus_morphology4.72608387
4MP0004957_abnormal_blastocyst_morpholog4.34119820
5MP0003077_abnormal_cell_cycle4.31387302
6MP0008057_abnormal_DNA_replication3.93767435
7* MP0008058_abnormal_DNA_repair3.64248201
8MP0008007_abnormal_cellular_replicative3.44110776
9MP0008877_abnormal_DNA_methylation3.37060606
10MP0008932_abnormal_embryonic_tissue2.68714508
11MP0002396_abnormal_hematopoietic_system2.52225009
12MP0001730_embryonic_growth_arrest2.21272922
13MP0000350_abnormal_cell_proliferation2.17185046
14MP0006292_abnormal_olfactory_placode2.11297148
15MP0003123_paternal_imprinting1.93532344
16MP0003786_premature_aging1.88568588
17MP0001697_abnormal_embryo_size1.65294577
18MP0001929_abnormal_gametogenesis1.60746237
19MP0002210_abnormal_sex_determination1.58989612
20MP0003763_abnormal_thymus_physiology1.55777248
21MP0000490_abnormal_crypts_of1.54854160
22MP0003121_genomic_imprinting1.54835834
23MP0001672_abnormal_embryogenesis/_devel1.51417101
24MP0005380_embryogenesis_phenotype1.51417101
25MP0000313_abnormal_cell_death1.50987190
26MP0002163_abnormal_gland_morphology1.50849155
27MP0002019_abnormal_tumor_incidence1.47592627
28MP0002080_prenatal_lethality1.47257218
29MP0005410_abnormal_fertilization1.45373979
30MP0004808_abnormal_hematopoietic_stem1.43400547
31MP0005395_other_phenotype1.43069895
32MP0010030_abnormal_orbit_morphology1.41757839
33MP0003950_abnormal_plasma_membrane1.41713576
34MP0002085_abnormal_embryonic_tissue1.41594659
35MP0003984_embryonic_growth_retardation1.36576377
36MP0003941_abnormal_skin_development1.35018187
37MP0001145_abnormal_male_reproductive1.34915307
38MP0009697_abnormal_copulation1.32374895
39MP0002653_abnormal_ependyma_morphology1.32235729
40MP0010352_gastrointestinal_tract_polyps1.31969634
41MP0002088_abnormal_embryonic_growth/wei1.31179569
42MP0000703_abnormal_thymus_morphology1.30649591
43MP0005397_hematopoietic_system_phenotyp1.29601001
44MP0001545_abnormal_hematopoietic_system1.29601001
45MP0002398_abnormal_bone_marrow1.29187171
46MP0005394_taste/olfaction_phenotype1.28951875
47MP0005499_abnormal_olfactory_system1.28951875
48MP0002084_abnormal_developmental_patter1.27946251
49MP0004133_heterotaxia1.27222696
50MP0010307_abnormal_tumor_latency1.25266871
51MP0008995_early_reproductive_senescence1.23693789
52MP0006072_abnormal_retinal_apoptosis1.21008621
53MP0001293_anophthalmia1.18433618
54MP0003890_abnormal_embryonic-extraembry1.17314906
55MP0000653_abnormal_sex_gland1.16823628
56MP0002254_reproductive_system_inflammat1.16590548
57MP0004197_abnormal_fetal_growth/weight/1.15752316
58MP0002722_abnormal_immune_system1.14740996
59MP0003698_abnormal_male_reproductive1.12093674
60MP0003718_maternal_effect1.11913070
61MP0002102_abnormal_ear_morphology1.10546381
62MP0000689_abnormal_spleen_morphology1.10251455
63MP0002086_abnormal_extraembryonic_tissu1.08430536
64MP0009333_abnormal_splenocyte_physiolog1.08142962
65MP0002160_abnormal_reproductive_system1.05672945
66MP0006036_abnormal_mitochondrial_physio1.04612614
67MP0002138_abnormal_hepatobiliary_system1.02788682
68MP0003937_abnormal_limbs/digits/tail_de1.01524775
69MP0005645_abnormal_hypothalamus_physiol1.00848084
70MP0006054_spinal_hemorrhage0.97481173
71MP0002429_abnormal_blood_cell0.96126544
72MP0002095_abnormal_skin_pigmentation0.94539463
73MP0003806_abnormal_nucleotide_metabolis0.93204646
74MP0005174_abnormal_tail_pigmentation0.91932474
75MP0002233_abnormal_nose_morphology0.90665437
76MP0000358_abnormal_cell_content/0.89542471
77MP0003567_abnormal_fetal_cardiomyocyte0.87788152
78MP0001119_abnormal_female_reproductive0.87670072
79MP0002751_abnormal_autonomic_nervous0.84868133
80MP0005671_abnormal_response_to0.84333604
81MP0000716_abnormal_immune_system0.82717460
82MP0004147_increased_porphyrin_level0.82440183
83MP0002161_abnormal_fertility/fecundity0.81789618
84MP0003787_abnormal_imprinting0.81718989
85MP0002234_abnormal_pharynx_morphology0.81678576
86MP0005384_cellular_phenotype0.81278002
87MP0000858_altered_metastatic_potential0.81193837
88MP0001915_intracranial_hemorrhage0.80727178
89MP0005084_abnormal_gallbladder_morpholo0.80616224
90MP0004233_abnormal_muscle_weight0.80287697
91MP0003136_yellow_coat_color0.77411713
92MP0009672_abnormal_birth_weight0.76947403
93MP0005389_reproductive_system_phenotype0.76317055
94MP0000015_abnormal_ear_pigmentation0.75031332
95MP0003221_abnormal_cardiomyocyte_apopto0.74349817
96MP0000631_abnormal_neuroendocrine_gland0.74029093
97MP0005075_abnormal_melanosome_morpholog0.73959103
98MP0003315_abnormal_perineum_morphology0.72842078
99MP0005621_abnormal_cell_physiology0.72708684
100MP0003119_abnormal_digestive_system0.72490207
101MP0002938_white_spotting0.71732227
102MP0000569_abnormal_digit_pigmentation0.70372930
103MP0005076_abnormal_cell_differentiation0.67996995
104MP0002075_abnormal_coat/hair_pigmentati0.67830039
105MP0003943_abnormal_hepatobiliary_system0.66874728
106MP0001835_abnormal_antigen_presentation0.66189311
107MP0000647_abnormal_sebaceous_gland0.64933506
108MP0001529_abnormal_vocalization0.64099223
109MP0001873_stomach_inflammation0.62726880
110MP0003186_abnormal_redox_activity0.62250009
111MP0000685_abnormal_immune_system0.62225618
112MP0000537_abnormal_urethra_morphology0.61975957
113MP0002420_abnormal_adaptive_immunity0.61582547
114MP0001286_abnormal_eye_development0.60478831
115MP0005171_absent_coat_pigmentation0.60462383
116MP0005379_endocrine/exocrine_gland_phen0.60413003
117MP0005391_vision/eye_phenotype0.60129198
118MP0001819_abnormal_immune_cell0.59486395
119MP0002697_abnormal_eye_size0.59447269
120MP0009703_decreased_birth_body0.57820805
121MP0002282_abnormal_trachea_morphology0.57777115
122MP0002111_abnormal_tail_morphology0.57755682
123MP0001800_abnormal_humoral_immune0.57626934
124MP0006035_abnormal_mitochondrial_morpho0.57551691
125MP0002405_respiratory_system_inflammati0.57133401
126MP0008789_abnormal_olfactory_epithelium0.56788379
127MP0003861_abnormal_nervous_system0.55918941
128MP0003699_abnormal_female_reproductive0.55858308
129MP0003755_abnormal_palate_morphology0.55386952
130MP0001346_abnormal_lacrimal_gland0.54804048
131MP0001186_pigmentation_phenotype0.54288446
132MP0005253_abnormal_eye_physiology0.54211460
133MP0000049_abnormal_middle_ear0.54191092

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.54458957
2Chromsome breakage (HP:0040012)3.85446217
3Reticulocytopenia (HP:0001896)3.64707099
4Chromosomal breakage induced by crosslinking agents (HP:0003221)3.60150278
5Degeneration of anterior horn cells (HP:0002398)3.58326709
6Abnormality of the anterior horn cell (HP:0006802)3.58326709
7Oral leukoplakia (HP:0002745)3.39202378
8Abnormality of cells of the erythroid lineage (HP:0012130)3.35691587
9Abnormal number of erythroid precursors (HP:0012131)3.35560360
10Medulloblastoma (HP:0002885)3.26323373
11Meckel diverticulum (HP:0002245)3.25398654
12Selective tooth agenesis (HP:0001592)3.25396460
13Patellar aplasia (HP:0006443)3.21051352
14Abnormality of chromosome stability (HP:0003220)3.18868061
15Abnormality of the preputium (HP:0100587)3.16912853
16Aplastic anemia (HP:0001915)3.15052883
17Abnormality of the ileum (HP:0001549)3.11980810
18Breast hypoplasia (HP:0003187)3.10911109
19Aplasia/Hypoplasia of the uvula (HP:0010293)3.06533480
20Ependymoma (HP:0002888)3.06333348
21Myelodysplasia (HP:0002863)2.99950275
22Duodenal stenosis (HP:0100867)2.99402498
23Small intestinal stenosis (HP:0012848)2.99402498
24Abnormal lung lobation (HP:0002101)2.96668869
25Agnosia (HP:0010524)2.96306486
26Cerebral hypomyelination (HP:0006808)2.93701324
27Colon cancer (HP:0003003)2.93089056
28Aplasia/Hypoplasia of the patella (HP:0006498)2.92944527
29Carpal bone hypoplasia (HP:0001498)2.72484315
30Hypoplasia of the capital femoral epiphysis (HP:0003090)2.65083230
3111 pairs of ribs (HP:0000878)2.63412935
32Premature graying of hair (HP:0002216)2.59039884
33Sloping forehead (HP:0000340)2.58808238
34Absent thumb (HP:0009777)2.53036093
35Supernumerary spleens (HP:0009799)2.51663537
36Increased nuchal translucency (HP:0010880)2.50761425
37Bone marrow hypocellularity (HP:0005528)2.45267059
38Abnormality of the duodenum (HP:0002246)2.43939516
39Abnormality of the pons (HP:0007361)2.39220047
40Aplasia/Hypoplasia of the sternum (HP:0006714)2.36021772
41Rough bone trabeculation (HP:0100670)2.30191598
42Nephroblastoma (Wilms tumor) (HP:0002667)2.29898788
43Abnormality of the septum pellucidum (HP:0007375)2.29300887
44Abnormality of pyrimidine metabolism (HP:0004353)2.26710396
45Cleft eyelid (HP:0000625)2.26399237
46Pallor (HP:0000980)2.26313556
47Abnormality of the labia minora (HP:0012880)2.25099808
48Abnormality of the renal collecting system (HP:0004742)2.23988842
49Tracheoesophageal fistula (HP:0002575)2.23303216
50Abnormality of the heme biosynthetic pathway (HP:0010472)2.22200948
51Abnormal number of incisors (HP:0011064)2.21686003
52Multiple enchondromatosis (HP:0005701)2.19303925
53Atrophy/Degeneration involving motor neurons (HP:0007373)2.18689912
54Septo-optic dysplasia (HP:0100842)2.18494671
55Cellular immunodeficiency (HP:0005374)2.17408250
56Ectopic kidney (HP:0000086)2.15456566
57Embryonal renal neoplasm (HP:0011794)2.15366446
58Microretrognathia (HP:0000308)2.12901839
59Abnormal biliary tract physiology (HP:0012439)2.12397769
60Bile duct proliferation (HP:0001408)2.12397769
61Abnormality of the carotid arteries (HP:0005344)2.10648481
62Pancreatic cysts (HP:0001737)2.09851802
63Abnormality of abdominal situs (HP:0011620)2.09360382
64Abdominal situs inversus (HP:0003363)2.09360382
65Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.08221555
66Absent epiphyses (HP:0010577)2.08221555
67Abnormality of DNA repair (HP:0003254)2.07681529
68Abnormal spermatogenesis (HP:0008669)2.07322500
69Molar tooth sign on MRI (HP:0002419)2.07158592
70Abnormality of midbrain morphology (HP:0002418)2.07158592
71Neoplasm of the pancreas (HP:0002894)2.06271692
72Premature ovarian failure (HP:0008209)2.05218012
73Abnormality of methionine metabolism (HP:0010901)2.03529150
74Thrombocytosis (HP:0001894)2.03218466
75Clubbing of toes (HP:0100760)2.02711145
76Absent septum pellucidum (HP:0001331)2.02292889
77Absent radius (HP:0003974)2.01391630
78Hypoplasia of the pons (HP:0012110)2.01217947
79Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.00864225
80Decreased activity of mitochondrial respiratory chain (HP:0008972)2.00864225
81Tongue fasciculations (HP:0001308)1.98750285
82Lymphoma (HP:0002665)1.98655522
83Atresia of the external auditory canal (HP:0000413)1.98062502
84Glioma (HP:0009733)1.97998240
85Impulsivity (HP:0100710)1.97323271
86Horseshoe kidney (HP:0000085)1.97278996
87Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.96839393
88Rhabdomyosarcoma (HP:0002859)1.96619876
89Dandy-Walker malformation (HP:0001305)1.96018044
90Type I transferrin isoform profile (HP:0003642)1.95331702
91Macrocytic anemia (HP:0001972)1.94199063
92Basal cell carcinoma (HP:0002671)1.93253702
93Bifid tongue (HP:0010297)1.93065761
94Amaurosis fugax (HP:0100576)1.92842685
95Proximal placement of thumb (HP:0009623)1.92717912
96Oligodactyly (hands) (HP:0001180)1.90666998
97Short 4th metacarpal (HP:0010044)1.90631805
98Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.90631805
99Neoplasm of the colon (HP:0100273)1.90165548
100Abnormality of aspartate family amino acid metabolism (HP:0010899)1.90092944
101Combined immunodeficiency (HP:0005387)1.89797065
102Aplasia involving forearm bones (HP:0009822)1.89402278
103Absent forearm bone (HP:0003953)1.89402278
104Cafe-au-lait spot (HP:0000957)1.88997393
105IgM deficiency (HP:0002850)1.88523781
106Pancytopenia (HP:0001876)1.88062785
107Acute encephalopathy (HP:0006846)1.87538990
108Deviation of the thumb (HP:0009603)1.87076525
109Volvulus (HP:0002580)1.86721763
110Acute necrotizing encephalopathy (HP:0006965)1.86254131
111Duplicated collecting system (HP:0000081)1.86174662
112Short thumb (HP:0009778)1.86076845
113Neoplasm of the adrenal cortex (HP:0100641)1.85791913
114Triphalangeal thumb (HP:0001199)1.84533490
115Hypoplastic pelvis (HP:0008839)1.82603968
116Severe combined immunodeficiency (HP:0004430)1.82298704
117Arteriovenous malformation (HP:0100026)1.81962376
118Irregular epiphyses (HP:0010582)1.81179927
119Slender long bone (HP:0003100)1.80713651
120Bilateral microphthalmos (HP:0007633)1.80243445
121Aplasia/Hypoplasia of the sacrum (HP:0008517)1.78977410
122Stenosis of the external auditory canal (HP:0000402)1.77268402
123CNS hypomyelination (HP:0003429)1.74639749
124Facial cleft (HP:0002006)1.74312546
125Type 2 muscle fiber atrophy (HP:0003554)1.74069704
126Choanal atresia (HP:0000453)1.73965902
1273-Methylglutaconic aciduria (HP:0003535)1.73553685
128Pulmonary fibrosis (HP:0002206)1.73135376
129Pancreatic fibrosis (HP:0100732)1.72329877
130Increased CSF lactate (HP:0002490)1.71269899
131Azoospermia (HP:0000027)1.70649780
132Abnormality of the astrocytes (HP:0100707)1.69973349
133Astrocytoma (HP:0009592)1.69973349
134Increased serum lactate (HP:0002151)1.66466525
135Nephronophthisis (HP:0000090)1.66418297
136Pendular nystagmus (HP:0012043)1.66262640
137Increased hepatocellular lipid droplets (HP:0006565)1.65726167
138Neoplasm of striated muscle (HP:0009728)1.64969271
139Microvesicular hepatic steatosis (HP:0001414)1.64628148
140Cortical dysplasia (HP:0002539)1.63638315
141Aplasia/Hypoplasia involving the musculature (HP:0001460)1.63496542
142IgA deficiency (HP:0002720)1.62833705
143Embryonal neoplasm (HP:0002898)1.62744288

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.51247314
2CDC74.47652107
3WEE13.94286981
4TSSK63.10083639
5EIF2AK12.79475483
6VRK22.64452659
7NEK22.64375374
8MST42.56689143
9NUAK12.35507773
10TTK2.31568138
11PASK2.25466701
12SRPK12.24577312
13PLK42.22029821
14TRIM282.20540062
15NEK12.19506975
16CCNB12.18938473
17BRSK22.09694005
18STK162.08080290
19PLK12.00916849
20VRK11.96907829
21ATR1.93096684
22CDK71.73893954
23CDK81.73368350
24TESK11.69902950
25BRSK11.64382932
26PLK31.63711912
27AURKB1.60596300
28TESK21.59458639
29RPS6KB21.58549608
30EIF2AK31.57434777
31MKNK11.53500172
32BMPR1B1.48801141
33TAF11.47413812
34EEF2K1.38931093
35AURKA1.33801643
36TGFBR11.32780384
37CHEK21.32000394
38MAP4K11.31481910
39DYRK31.28626062
40STK101.26488955
41TLK11.22437821
42CDK41.22376961
43ACVR1B1.21878989
44CHEK11.15507690
45WNK31.12241123
46MAP4K21.06061217
47MAP3K81.04358492
48BRAF1.04216092
49PDK41.02215047
50PDK31.02215047
51NME20.99709714
52RPS6KA40.99571374
53CDK120.98409272
54PAK40.98294218
55NME10.94802896
56STK30.92640856
57FLT30.88582607
58PIM20.88472410
59KDR0.87151870
60MAP3K100.86971338
61BTK0.86900405
62* ATM0.86207135
63MKNK20.82079149
64TIE10.81180972
65SCYL20.78401800
66BCR0.77558341
67TNIK0.77478457
68CDK20.77288941
69ZAK0.74404232
70STK40.73797475
71STK38L0.70410608
72BRD40.70080210
73DAPK10.68566418
74STK240.68117326
75PIM10.67963219
76CDK190.65894199
77CSNK2A10.64915583
78PDK20.64671458
79PAK10.64505625
80ZAP700.64457942
81CSNK1G10.64249876
82TAOK20.63410789
83CLK10.63409675
84CSNK2A20.62865923
85LATS10.62792706
86CDK10.60433962
87GRK10.59376964
88EIF2AK20.58310906
89PRKCI0.57160231
90PBK0.56708590
91MELK0.55671781
92TEC0.54121084
93MAP3K60.52068098
94MAP3K110.51468658
95CDK60.50761398
96FRK0.50648626
97MAP3K130.46653914
98BLK0.45729069
99CSNK1G30.44941077
100TXK0.43882836
101NEK60.43390908
102MAP2K30.42843659
103INSRR0.41124039
104STK390.40430002
105CDK30.39973457
106PKN20.37256061
107CSNK1A1L0.36839209
108FGFR10.35465755
109ABL20.34792573
110ILK0.34472117
111CSNK1E0.34018662
112IRAK40.33444958
113RPS6KA50.33004518
114PLK20.31242919
115LYN0.31239986
116YES10.30648380
117RAF10.30526190
118MAPKAPK30.29711129
119LRRK20.29420442
120CDK90.29376367
121AKT20.29346186
122BCKDK0.29301296
123ALK0.28391436
124* PRKDC0.27573569
125SMG10.27496326
126KIT0.27395435
127PNCK0.25694326
128CSNK1G20.25620553
129CSF1R0.24798091
130MARK30.24710930
131LIMK10.24192337
132SIK30.23872848
133RPS6KB10.23412990
134NLK0.22651799
135DYRK20.21776548

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.31940145
2Mismatch repair_Homo sapiens_hsa034304.69986945
3Base excision repair_Homo sapiens_hsa034103.62888668
4Spliceosome_Homo sapiens_hsa030403.30236703
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.21204336
6Homologous recombination_Homo sapiens_hsa034403.20246866
7Proteasome_Homo sapiens_hsa030503.16427576
8Nucleotide excision repair_Homo sapiens_hsa034203.04403980
9RNA transport_Homo sapiens_hsa030133.03388639
10RNA polymerase_Homo sapiens_hsa030202.89464301
11Ribosome_Homo sapiens_hsa030102.85735844
12Cell cycle_Homo sapiens_hsa041102.85099399
13Non-homologous end-joining_Homo sapiens_hsa034502.55516155
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.46920033
15Fanconi anemia pathway_Homo sapiens_hsa034602.43302609
16Pyrimidine metabolism_Homo sapiens_hsa002402.42312400
17One carbon pool by folate_Homo sapiens_hsa006702.37844882
18RNA degradation_Homo sapiens_hsa030182.23074666
19Basal transcription factors_Homo sapiens_hsa030222.10759002
20mRNA surveillance pathway_Homo sapiens_hsa030151.74712409
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.51597282
22p53 signaling pathway_Homo sapiens_hsa041151.42225494
23Purine metabolism_Homo sapiens_hsa002301.38312637
24Propanoate metabolism_Homo sapiens_hsa006401.35617893
25Epstein-Barr virus infection_Homo sapiens_hsa051691.23615401
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.14392589
27Protein export_Homo sapiens_hsa030601.10715084
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.10343449
29Oocyte meiosis_Homo sapiens_hsa041141.08910182
30Antigen processing and presentation_Homo sapiens_hsa046121.08345046
31Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.00340223
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.96118813
33Herpes simplex infection_Homo sapiens_hsa051680.93800586
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.93608328
35Primary immunodeficiency_Homo sapiens_hsa053400.92221461
36Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.91771713
37Biosynthesis of amino acids_Homo sapiens_hsa012300.91541640
38Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.90667230
39Steroid biosynthesis_Homo sapiens_hsa001000.87316224
40Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.85866516
41Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.85395961
42Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.84402313
43Viral carcinogenesis_Homo sapiens_hsa052030.83941752
44Pentose phosphate pathway_Homo sapiens_hsa000300.80418627
45Cysteine and methionine metabolism_Homo sapiens_hsa002700.80089578
46HTLV-I infection_Homo sapiens_hsa051660.78210182
47Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.77362100
48Systemic lupus erythematosus_Homo sapiens_hsa053220.75515579
49Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.74311547
50Huntingtons disease_Homo sapiens_hsa050160.72407939
51Legionellosis_Homo sapiens_hsa051340.71334601
52N-Glycan biosynthesis_Homo sapiens_hsa005100.68319712
53Fatty acid elongation_Homo sapiens_hsa000620.66356802
54Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.65683982
55Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.61206832
56Vitamin B6 metabolism_Homo sapiens_hsa007500.60390798
57Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.58569491
58Carbon metabolism_Homo sapiens_hsa012000.54023814
59Phototransduction_Homo sapiens_hsa047440.52416439
60Measles_Homo sapiens_hsa051620.51200063
61Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.50538146
62Lysine degradation_Homo sapiens_hsa003100.50012674
63Parkinsons disease_Homo sapiens_hsa050120.49167306
64Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.48214752
65Selenocompound metabolism_Homo sapiens_hsa004500.46903472
66Cyanoamino acid metabolism_Homo sapiens_hsa004600.46798039
67Colorectal cancer_Homo sapiens_hsa052100.44830232
68Shigellosis_Homo sapiens_hsa051310.44548894
69Drug metabolism - other enzymes_Homo sapiens_hsa009830.40662991
70Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.40362842
71Transcriptional misregulation in cancer_Homo sapiens_hsa052020.39997773
72Galactose metabolism_Homo sapiens_hsa000520.38506828
73Small cell lung cancer_Homo sapiens_hsa052220.36926421
74Thyroid cancer_Homo sapiens_hsa052160.36259194
75Sulfur relay system_Homo sapiens_hsa041220.35567200
76Apoptosis_Homo sapiens_hsa042100.34844375
77MicroRNAs in cancer_Homo sapiens_hsa052060.34144240
78Hepatitis B_Homo sapiens_hsa051610.32124178
79NF-kappa B signaling pathway_Homo sapiens_hsa040640.31780156
80Folate biosynthesis_Homo sapiens_hsa007900.31587836
81Basal cell carcinoma_Homo sapiens_hsa052170.28191714
82Pyruvate metabolism_Homo sapiens_hsa006200.27934840
83Fructose and mannose metabolism_Homo sapiens_hsa000510.27216509
84Alcoholism_Homo sapiens_hsa050340.26862709
85HIF-1 signaling pathway_Homo sapiens_hsa040660.26795067
86Wnt signaling pathway_Homo sapiens_hsa043100.25130991
872-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.24557348
88Central carbon metabolism in cancer_Homo sapiens_hsa052300.24403177
89Alzheimers disease_Homo sapiens_hsa050100.23583032
90Glutathione metabolism_Homo sapiens_hsa004800.23018606
91Oxidative phosphorylation_Homo sapiens_hsa001900.23007798
92Chronic myeloid leukemia_Homo sapiens_hsa052200.22194888
93Influenza A_Homo sapiens_hsa051640.21103340
94Caffeine metabolism_Homo sapiens_hsa002320.20631609
95Hematopoietic cell lineage_Homo sapiens_hsa046400.20392367
96Regulation of autophagy_Homo sapiens_hsa041400.20049812
97Butanoate metabolism_Homo sapiens_hsa006500.19658106
98Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.18712109
99Notch signaling pathway_Homo sapiens_hsa043300.18646340
100Pathways in cancer_Homo sapiens_hsa052000.18442586
101Hippo signaling pathway_Homo sapiens_hsa043900.17338449
102TGF-beta signaling pathway_Homo sapiens_hsa043500.15786960
103Metabolic pathways_Homo sapiens_hsa011000.15355903
104Acute myeloid leukemia_Homo sapiens_hsa052210.14896764
105Glycosaminoglycan degradation_Homo sapiens_hsa005310.14807487
106Pancreatic cancer_Homo sapiens_hsa052120.14692116
107Asthma_Homo sapiens_hsa053100.14434744
108Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.13106968
109Fatty acid metabolism_Homo sapiens_hsa012120.12936820
110B cell receptor signaling pathway_Homo sapiens_hsa046620.12061238
111Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.11873185
112Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.11468120
113Type I diabetes mellitus_Homo sapiens_hsa049400.11224144
114Peroxisome_Homo sapiens_hsa041460.10762066
115RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.10632837
116Other glycan degradation_Homo sapiens_hsa005110.09369974
117Hedgehog signaling pathway_Homo sapiens_hsa043400.08969310
118Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.08968567
119Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.08577815
120Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.08419425
121Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.08029293
122Bladder cancer_Homo sapiens_hsa052190.07720918
123Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.06375054
124Adherens junction_Homo sapiens_hsa045200.05349538
125Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.04707254
126Prostate cancer_Homo sapiens_hsa052150.02848315
127T cell receptor signaling pathway_Homo sapiens_hsa04660-0.0013816

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