TDP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a superfamily of divalent cation-dependent phosphodiesterases. The encoded protein associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor associated factors (TRAFs), and inhibits nuclear factor-kappa-B activation. This protein has sequence and structural similarities with APE1 endonuclease, which is involved in both DNA repair and the activation of transcription factors. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1angiotensin maturation (GO:0002003)6.51684770
2fat-soluble vitamin biosynthetic process (GO:0042362)5.35725661
3glycosphingolipid catabolic process (GO:0046479)5.13320581
4DNA strand elongation involved in DNA replication (GO:0006271)4.98736486
5DNA replication initiation (GO:0006270)4.87964182
6glycolipid catabolic process (GO:0019377)4.80736985
7DNA unwinding involved in DNA replication (GO:0006268)4.77346892
8telomere maintenance via semi-conservative replication (GO:0032201)4.77091637
9DNA strand elongation (GO:0022616)4.73313378
10DNA replication checkpoint (GO:0000076)4.62947959
11lipoprotein transport (GO:0042953)4.47308124
12regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.43052942
13protein localization to kinetochore (GO:0034501)4.35195154
14telomere maintenance via recombination (GO:0000722)4.29402456
15purine nucleobase biosynthetic process (GO:0009113)4.27908768
16nucleobase biosynthetic process (GO:0046112)4.20123779
17chromatin remodeling at centromere (GO:0031055)4.18858669
18mitotic metaphase plate congression (GO:0007080)4.15968227
19mitotic recombination (GO:0006312)4.12893506
20DNA replication-dependent nucleosome assembly (GO:0006335)4.08828068
21DNA replication-dependent nucleosome organization (GO:0034723)4.08828068
22CENP-A containing nucleosome assembly (GO:0034080)4.07474188
23nuclear pore organization (GO:0006999)4.07398342
24oligosaccharide catabolic process (GO:0009313)4.04958783
25regulation of vitamin metabolic process (GO:0030656)4.04247038
26ceramide catabolic process (GO:0046514)4.04204802
27DNA deamination (GO:0045006)4.00805738
28attachment of spindle microtubules to kinetochore (GO:0008608)3.98629794
29neutrophil activation involved in immune response (GO:0002283)3.94668750
30regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.88201050
31protein localization to chromosome, centromeric region (GO:0071459)3.86721913
32metaphase plate congression (GO:0051310)3.85878376
33DNA replication-independent nucleosome assembly (GO:0006336)3.84090744
34DNA replication-independent nucleosome organization (GO:0034724)3.84090744
35intestinal absorption (GO:0050892)3.79745013
36folic acid-containing compound biosynthetic process (GO:0009396)3.78735847
37telomere maintenance via telomere lengthening (GO:0010833)3.75287199
38peptide catabolic process (GO:0043171)3.74501312
39mitotic nuclear envelope disassembly (GO:0007077)3.73984243
40nuclear pore complex assembly (GO:0051292)3.73969165
41mitotic chromosome condensation (GO:0007076)3.73890367
42nucleotide-excision repair, DNA gap filling (GO:0006297)3.71826865
43negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.69459425
44negative regulation of cell killing (GO:0031342)3.69459425
45maturation of SSU-rRNA (GO:0030490)3.67548067
46antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.66899621
47kinetochore organization (GO:0051383)3.66787642
48very-low-density lipoprotein particle assembly (GO:0034379)3.65179015
49antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.64295884
50membrane lipid catabolic process (GO:0046466)3.63401837
51regulation of guanylate cyclase activity (GO:0031282)3.62506231
52ribosomal small subunit assembly (GO:0000028)3.62322313
53epoxygenase P450 pathway (GO:0019373)3.61226383
54sphingolipid catabolic process (GO:0030149)3.59994547
55antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.58109574
56negative regulation of interleukin-12 production (GO:0032695)3.54410055
57ribosome biogenesis (GO:0042254)3.50645871
58IMP biosynthetic process (GO:0006188)3.49931157
59regulation of cellular extravasation (GO:0002691)3.49720789
60histone exchange (GO:0043486)3.46711648
61plasma lipoprotein particle assembly (GO:0034377)3.46643884
62formation of translation preinitiation complex (GO:0001731)3.46148213
63membrane disassembly (GO:0030397)3.45740351
64nuclear envelope disassembly (GO:0051081)3.45740351
65mitotic sister chromatid segregation (GO:0000070)3.44929724
66modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.44602104
67positive regulation by organism of defense response of other organism involved in symbiotic interact3.44602104
68modulation by symbiont of host immune response (GO:0052553)3.44602104
69positive regulation by symbiont of host defense response (GO:0052509)3.44602104
70modulation by symbiont of host defense response (GO:0052031)3.44602104
71modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.44602104
72ribosome assembly (GO:0042255)3.42634244
73antigen processing and presentation of endogenous antigen (GO:0019883)3.41840850
74regulation of double-strand break repair via homologous recombination (GO:0010569)3.39208265
75macrophage activation involved in immune response (GO:0002281)3.37076852
76regulation of cytokine secretion involved in immune response (GO:0002739)3.35551679
77immunoglobulin mediated immune response (GO:0016064)3.32662174
78phospholipid efflux (GO:0033700)3.32355196
79kinetochore assembly (GO:0051382)3.31700625
80protein-lipid complex assembly (GO:0065005)3.30856705
81DNA duplex unwinding (GO:0032508)3.30658399
82cellular response to thyroid hormone stimulus (GO:0097067)3.30557764
83DNA geometric change (GO:0032392)3.30316344
84establishment of chromosome localization (GO:0051303)3.30013328
85regulation of mononuclear cell migration (GO:0071675)3.29847764
86regulation of cholesterol esterification (GO:0010872)3.26451858
87regulation of spindle organization (GO:0090224)3.25828221
88response to peptidoglycan (GO:0032494)3.21624661
89NADH metabolic process (GO:0006734)3.21147509
90regulation of nuclear cell cycle DNA replication (GO:0033262)3.21070934
91negative regulation of chromosome segregation (GO:0051985)3.19082446
92T-helper 1 type immune response (GO:0042088)3.18594004
93adhesion of symbiont to host cell (GO:0044650)3.18271616
94virion attachment to host cell (GO:0019062)3.18271616
95ribonucleoprotein complex biogenesis (GO:0022613)3.18082149
96meiotic chromosome segregation (GO:0045132)3.17465390
97sister chromatid segregation (GO:0000819)3.16400634
98chromatin assembly or disassembly (GO:0006333)3.16133889
99negative regulation of mitotic sister chromatid separation (GO:2000816)3.15826920
100negative regulation of mitotic sister chromatid segregation (GO:0033048)3.15826920
101negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.15826920
102negative regulation of sister chromatid segregation (GO:0033046)3.15826920
103somatic hypermutation of immunoglobulin genes (GO:0016446)3.15417716
104somatic diversification of immune receptors via somatic mutation (GO:0002566)3.15417716
105positive regulation of gamma-delta T cell activation (GO:0046645)3.15262470
106IMP metabolic process (GO:0046040)3.15184899
107folic acid metabolic process (GO:0046655)3.15107226
108spindle checkpoint (GO:0031577)3.12122296
109spindle assembly checkpoint (GO:0071173)3.11629187
110regulation of chromosome segregation (GO:0051983)3.10942143
111detection of other organism (GO:0098543)3.08207824
112mitotic spindle assembly checkpoint (GO:0007094)3.07430899
113negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.07012104
114positive regulation of lipoprotein lipase activity (GO:0051006)3.06347578
115positive regulation of triglyceride lipase activity (GO:0061365)3.06347578
116negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.05191543
117vitamin D metabolic process (GO:0042359)3.05171488
118regulation of interferon-beta biosynthetic process (GO:0045357)3.04244836
119regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.03625110
120translational termination (GO:0006415)3.02046674
121transcription-coupled nucleotide-excision repair (GO:0006283)3.01791342
122ribosomal large subunit biogenesis (GO:0042273)3.01449214
123regulation of mitotic metaphase/anaphase transition (GO:0030071)3.00524644
124protein localization to chromosome (GO:0034502)2.99862142
125viral transcription (GO:0019083)2.99484993
126rRNA processing (GO:0006364)2.99448376
127DNA synthesis involved in DNA repair (GO:0000731)2.98988610
128mitotic spindle checkpoint (GO:0071174)2.96889302
129telomere maintenance (GO:0000723)2.96489929
130glycoside metabolic process (GO:0016137)2.96205652
131telomere organization (GO:0032200)2.95910729
132regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.94060974
133regulation of podosome assembly (GO:0071801)2.91884460
134maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.90511490
135rRNA metabolic process (GO:0016072)2.90490565
136positive regulation of Cdc42 GTPase activity (GO:0043089)2.89573390
137transcytosis (GO:0045056)2.89418132
138DNA conformation change (GO:0071103)2.89040553
139fructose metabolic process (GO:0006000)2.89037479
140regulation of helicase activity (GO:0051095)2.88802433
141granulocyte activation (GO:0036230)2.88719720
142cyclooxygenase pathway (GO:0019371)2.88522014
143dosage compensation (GO:0007549)2.88052603
144spliceosomal snRNP assembly (GO:0000387)2.87470583
145regulation of sister chromatid segregation (GO:0033045)2.86783448
146regulation of mitotic sister chromatid separation (GO:0010965)2.86783448
147regulation of mitotic sister chromatid segregation (GO:0033047)2.86783448
148pore complex assembly (GO:0046931)2.86268148
149translesion synthesis (GO:0019985)2.85998841
150postreplication repair (GO:0006301)2.85995317
151translational elongation (GO:0006414)2.84858280
152positive regulation of chromosome segregation (GO:0051984)2.84668077
153lipopolysaccharide-mediated signaling pathway (GO:0031663)2.84145320
154ATP-dependent chromatin remodeling (GO:0043044)2.84035152
155protein K6-linked ubiquitination (GO:0085020)2.83876571
156chromosome segregation (GO:0007059)2.83382653
157detection of bacterium (GO:0016045)2.81621455
158termination of RNA polymerase II transcription (GO:0006369)2.81269596
159positive regulation of leukocyte degranulation (GO:0043302)2.81185724
160pteridine-containing compound biosynthetic process (GO:0042559)2.80314696
161pseudouridine synthesis (GO:0001522)2.79285852
162hormone catabolic process (GO:0042447)2.79236178
163NIK/NF-kappaB signaling (GO:0038061)2.79116550
164fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.78832457
165eosinophil chemotaxis (GO:0048245)2.78758989
166uronic acid metabolic process (GO:0006063)2.75770001
167glucuronate metabolic process (GO:0019585)2.75770001
168cellular glucuronidation (GO:0052695)2.73346578
169detection of molecule of bacterial origin (GO:0032490)2.72513262
170bile acid and bile salt transport (GO:0015721)2.71407680
171detection of external biotic stimulus (GO:0098581)2.71396803
172regulation of vitamin D biosynthetic process (GO:0060556)2.70916657
173regulation of bile acid biosynthetic process (GO:0070857)2.70618249
174respiratory burst (GO:0045730)2.70505222
175response to thyroid hormone (GO:0097066)2.70050956
176B cell mediated immunity (GO:0019724)2.69841909
177positive regulation of cellular amide metabolic process (GO:0034250)2.69143364
178interferon-gamma-mediated signaling pathway (GO:0060333)2.66679772
179low-density lipoprotein particle remodeling (GO:0034374)2.66260954
180maintenance of gastrointestinal epithelium (GO:0030277)2.66015741
181adhesion of symbiont to host (GO:0044406)2.65616441
182cholesterol efflux (GO:0033344)2.65500790
183regulation of superoxide anion generation (GO:0032928)2.65310916
184neutrophil activation (GO:0042119)2.64999152
185positive regulation of antigen processing and presentation (GO:0002579)2.64833399
186dendritic cell chemotaxis (GO:0002407)2.60999752
187positive regulation of guanylate cyclase activity (GO:0031284)2.58541650
188diacylglycerol metabolic process (GO:0046339)2.58032791
189regulation of triglyceride catabolic process (GO:0010896)2.57186235
190leukotriene metabolic process (GO:0006691)2.55840275
191regulation of cholesterol storage (GO:0010885)2.54955080
192N-acetylneuraminate metabolic process (GO:0006054)2.54688171
193amino sugar catabolic process (GO:0046348)2.53878583
194regulation of dendritic cell antigen processing and presentation (GO:0002604)2.53069837
195urea cycle (GO:0000050)2.52023633
196negative regulation of establishment of protein localization to plasma membrane (GO:0090005)2.51927578
197lipoprotein metabolic process (GO:0042157)2.51520339
198myeloid dendritic cell differentiation (GO:0043011)2.49685175
199positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.49598162
200regulation of macrophage chemotaxis (GO:0010758)2.48448385

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.41003817
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.77809169
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.58780936
4MYC_18555785_ChIP-Seq_MESCs_Mouse4.14440763
5FOXM1_23109430_ChIP-Seq_U2OS_Human4.09176318
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.83728480
7BP1_19119308_ChIP-ChIP_Hs578T_Human3.80676861
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.79661990
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.43269988
10SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.28057541
11IRF8_27001747_Chip-Seq_BMDM_Mouse3.24393171
12* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.20579196
13NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.11905021
14NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.98938768
15Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.79703046
16MYB_21317192_ChIP-Seq_ERMYB_Mouse2.79549404
17RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.78454000
18KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.75530420
19MYC_19030024_ChIP-ChIP_MESCs_Mouse2.70398098
20MYC_19079543_ChIP-ChIP_MESCs_Mouse2.70075541
21ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.70004435
22MYC_18358816_ChIP-ChIP_MESCs_Mouse2.64402467
23MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.50360584
24EST1_17652178_ChIP-ChIP_JURKAT_Human2.48929427
25STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.45733411
26GABP_17652178_ChIP-ChIP_JURKAT_Human2.44822002
27NELFA_20434984_ChIP-Seq_ESCs_Mouse2.39544569
28CREB1_15753290_ChIP-ChIP_HEK293T_Human2.37954913
29AR_21909140_ChIP-Seq_LNCAP_Human2.35210609
30JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.32777260
31ETS1_20019798_ChIP-Seq_JURKAT_Human2.31417099
32FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.24285703
33IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.21285274
34XRN2_22483619_ChIP-Seq_HELA_Human2.19423111
35MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.17495794
36CDX2_20551321_ChIP-Seq_CACO-2_Human2.16294147
37E2F1_21310950_ChIP-Seq_MCF-7_Human2.14414420
38HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.10563177
39VDR_23849224_ChIP-Seq_CD4+_Human2.06581084
40CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.00782985
41SOX2_27498859_Chip-Seq_STOMACH_Mouse1.98246694
42HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.97400828
43EGR1_19374776_ChIP-ChIP_THP-1_Human1.96180709
44STAT4_19710469_ChIP-ChIP_TH1__Mouse1.95724035
45E2F1_18555785_ChIP-Seq_MESCs_Mouse1.94722522
46RXR_22158963_ChIP-Seq_LIVER_Mouse1.94119504
47BRD4_27068464_Chip-Seq_AML-cells_Mouse1.92949639
48MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.92315974
49DCP1A_22483619_ChIP-Seq_HELA_Human1.89765283
50MYCN_18555785_ChIP-Seq_MESCs_Mouse1.88230615
51STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.86530464
52PPARA_22158963_ChIP-Seq_LIVER_Mouse1.85570599
53* FOXP3_21729870_ChIP-Seq_TREG_Human1.85094595
54PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.82875410
55KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.81901859
56LXR_22158963_ChIP-Seq_LIVER_Mouse1.79796188
57ELF1_17652178_ChIP-ChIP_JURKAT_Human1.79060451
58VDR_24787735_ChIP-Seq_THP-1_Human1.76661086
59CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.73815109
60SPI1_23127762_ChIP-Seq_K562_Human1.73333082
61GABP_19822575_ChIP-Seq_HepG2_Human1.73091189
62* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.72920792
63VDR_24763502_ChIP-Seq_THP-1_Human1.69551958
64MYC_22102868_ChIP-Seq_BL_Human1.69461036
65ZFX_18555785_ChIP-Seq_MESCs_Mouse1.69445308
66FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.67235268
67CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.66429805
68NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.66271675
69POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.65636446
70TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.63754709
71TTF2_22483619_ChIP-Seq_HELA_Human1.61546906
72STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.60352070
73NANOG_18555785_ChIP-Seq_MESCs_Mouse1.58305332
74FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.56522022
75RUNX1_22412390_ChIP-Seq_EML_Mouse1.56324056
76SOX2_20726797_ChIP-Seq_SW620_Human1.55100119
77GATA2_22383799_ChIP-Seq_G1ME_Mouse1.52073169
78CIITA_25753668_ChIP-Seq_RAJI_Human1.50890090
79GATA1_22025678_ChIP-Seq_K562_Human1.49744332
80CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.49237028
81GATA4_25053715_ChIP-Seq_YYC3_Human1.48661560
82THAP11_20581084_ChIP-Seq_MESCs_Mouse1.48131414
83MYB_26560356_Chip-Seq_TH2_Human1.47045421
84PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.45740235
85HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.44340304
86ELK1_19687146_ChIP-ChIP_HELA_Human1.44159050
87HOXB4_20404135_ChIP-ChIP_EML_Mouse1.44106787
88ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.43110416
89GATA1_22383799_ChIP-Seq_G1ME_Mouse1.39863895
90GATA6_25053715_ChIP-Seq_YYC3_Human1.39393000
91PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.38582467
92YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.38211173
93EGR1_23403033_ChIP-Seq_LIVER_Mouse1.37755151
94RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.35886012
95KDM5A_27292631_Chip-Seq_BREAST_Human1.35342122
96STAT3_1855785_ChIP-Seq_MESCs_Mouse1.34629401
97TP63_19390658_ChIP-ChIP_HaCaT_Human1.34295285
98CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.33483979
99MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.32665250
100SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.32661642
101CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.32622111
102ERG_20887958_ChIP-Seq_HPC-7_Mouse1.32432198
103E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.31736069
104SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.30667624
105E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.29997105
106NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.29661616
107NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.26962018
108KLF4_18555785_ChIP-Seq_MESCs_Mouse1.26309867
109ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.26253554
110PU_27001747_Chip-Seq_BMDM_Mouse1.25531304
111FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.25330785
112SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.23651326
113MYB_26560356_Chip-Seq_TH1_Human1.23449311
114TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.22365669
115PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.22026909
116POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.20958353
117VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.19977957
118CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.19428046
119PADI4_21655091_ChIP-ChIP_MCF-7_Human1.17102991
120E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.16318236
121RUNX_20019798_ChIP-Seq_JUKART_Human1.15255763
122SOX2_18555785_ChIP-Seq_MESCs_Mouse1.15208634
123FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.14684157
124RBPJ_22232070_ChIP-Seq_NCS_Mouse1.14666484
125FOXO3_23340844_ChIP-Seq_DLD1_Human1.14623581
126CLOCK_20551151_ChIP-Seq_293T_Human1.14500135
127SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14202535
128SRF_21415370_ChIP-Seq_HL-1_Mouse1.13561709
129CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.12960440
130GATA2_19941826_ChIP-Seq_K562_Human1.12109090
131GATA1_19941826_ChIP-Seq_K562_Human1.11936872
132TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.11790095
133POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.10583493
134CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09807192
135KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.09753838
136TFEB_21752829_ChIP-Seq_HELA_Human1.09151574
137CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.08890456
138YY1_21170310_ChIP-Seq_MESCs_Mouse1.07532567
139LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.06874178
140CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.06801311
141MAF_26560356_Chip-Seq_TH1_Human1.06721107
142PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06343433
143NOTCH1_21737748_ChIP-Seq_TLL_Human1.06330099
144ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.05166985
145GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.04274610
146SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.03674201
147DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.02754057
148PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01762361
149TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.01015912
150MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.00393159
151SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.99475621
152CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.98599250
153MYC_18940864_ChIP-ChIP_HL60_Human0.98370269
154TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98359878
155FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.98119779
156SALL4_18804426_ChIP-ChIP_XEN_Mouse0.97282154
157CDX2_19796622_ChIP-Seq_MESCs_Mouse0.97189646
158GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.97043941
159CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.96593818
160FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.94891687
161SCL_19346495_ChIP-Seq_HPC-7_Human0.94820591
162KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.94176848
163CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.92447041
164KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.92146760
165PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.92060971
166LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.91670769
167SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.91567778
168BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.91529709
169SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.91083580
170TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90237900
171GATA2_21666600_ChIP-Seq_HMVEC_Human0.90127885
172VDR_21846776_ChIP-Seq_THP-1_Human0.89927624
173AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.89022767
174GATA1_19941827_ChIP-Seq_MEL_Mouse0.88970645
175KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.88050266
176STAT1_20625510_ChIP-Seq_HELA_Human0.87847412
177GATA3_27048872_Chip-Seq_THYMUS_Human0.87221540
178GATA3_26560356_Chip-Seq_TH2_Human0.86726608
179PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.86711709
180ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.86402565
181SPI1_23547873_ChIP-Seq_NB4_Human0.85801989
182THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.85554989
183KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.85288243
184KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.85288243
185KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.85288243
186SALL1_21062744_ChIP-ChIP_HESCs_Human0.84429017
187CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.84187486
188TCF3_18692474_ChIP-Seq_MEFs_Mouse0.83383303
189TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.80658600
190HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.79278094
191NANOG_21062744_ChIP-ChIP_HESCs_Human0.77518117

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.11099304
2MP0010094_abnormal_chromosome_stability4.66280642
3MP0004957_abnormal_blastocyst_morpholog4.17727398
4MP0003111_abnormal_nucleus_morphology4.07177602
5MP0008057_abnormal_DNA_replication3.94689650
6MP0003077_abnormal_cell_cycle3.77238950
7MP0008058_abnormal_DNA_repair3.19779508
8MP0003303_peritoneal_inflammation3.13094005
9MP0003724_increased_susceptibility_to3.03889918
10MP0005058_abnormal_lysosome_morphology2.95458623
11MP0003183_abnormal_peptide_metabolism2.93005771
12MP0008877_abnormal_DNA_methylation2.69112741
13MP0003436_decreased_susceptibility_to2.65230801
14MP0008007_abnormal_cellular_replicative2.61388944
15MP0010155_abnormal_intestine_physiology2.57613959
16MP0006082_CNS_inflammation2.55825588
17MP0003191_abnormal_cellular_cholesterol2.40970998
18MP0009785_altered_susceptibility_to2.40295734
19MP0003806_abnormal_nucleotide_metabolis2.38921841
20MP0001666_abnormal_nutrient_absorption2.33917643
21MP0010234_abnormal_vibrissa_follicle2.33278542
22MP0002396_abnormal_hematopoietic_system2.30252093
23MP0008932_abnormal_embryonic_tissue2.29529289
24MP0002148_abnormal_hypersensitivity_rea2.29457562
25MP0001835_abnormal_antigen_presentation2.27997206
26MP0003786_premature_aging2.20513657
27MP0004019_abnormal_vitamin_homeostasis2.16827835
28MP0001730_embryonic_growth_arrest2.15698619
29MP0010352_gastrointestinal_tract_polyps2.09476654
30MP0000350_abnormal_cell_proliferation2.09196938
31MP0003123_paternal_imprinting2.03007351
32MP0002419_abnormal_innate_immunity1.97304498
33MP0005025_abnormal_response_to1.93543756
34MP0003300_gastrointestinal_ulcer1.93353167
35MP0005671_abnormal_response_to1.93174244
36MP0001790_abnormal_immune_system1.92081261
37MP0005387_immune_system_phenotype1.92081261
38MP0005000_abnormal_immune_tolerance1.88618682
39MP0000490_abnormal_crypts_of1.86344811
40MP0005451_abnormal_body_composition1.80730694
41MP0010307_abnormal_tumor_latency1.80710459
42MP0003172_abnormal_lysosome_physiology1.80153164
43MP0000604_amyloidosis1.70238999
44MP0001845_abnormal_inflammatory_respons1.67975817
45MP0001672_abnormal_embryogenesis/_devel1.66304229
46MP0005380_embryogenesis_phenotype1.66304229
47MP0004808_abnormal_hematopoietic_stem1.63082944
48MP0002452_abnormal_antigen_presenting1.60970976
49MP0001800_abnormal_humoral_immune1.60878638
50MP0003866_abnormal_defecation1.58567350
51MP0002723_abnormal_immune_serum1.58307655
52MP0002210_abnormal_sex_determination1.57720483
53MP0009764_decreased_sensitivity_to1.53332003
54MP0002139_abnormal_hepatobiliary_system1.53148717
55MP0005310_abnormal_salivary_gland1.53022381
56MP0001533_abnormal_skeleton_physiology1.52793421
57MP0000685_abnormal_immune_system1.52781666
58MP0005166_decreased_susceptibility_to1.51844148
59MP0001697_abnormal_embryo_size1.51439358
60MP0003984_embryonic_growth_retardation1.49493848
61MP0003567_abnormal_fetal_cardiomyocyte1.48938865
62MP0004947_skin_inflammation1.47981867
63MP0002019_abnormal_tumor_incidence1.47842516
64MP0003718_maternal_effect1.47814540
65MP0002080_prenatal_lethality1.46653019
66MP0008469_abnormal_protein_level1.45024983
67MP0002088_abnormal_embryonic_growth/wei1.44962245
68MP0001545_abnormal_hematopoietic_system1.44757651
69MP0005397_hematopoietic_system_phenotyp1.44757651
70MP0006292_abnormal_olfactory_placode1.43466721
71MP0005464_abnormal_platelet_physiology1.42984535
72MP0000313_abnormal_cell_death1.41733515
73MP0001145_abnormal_male_reproductive1.41147744
74MP0008260_abnormal_autophagy1.40427121
75MP0001819_abnormal_immune_cell1.39120406
76MP0002420_abnormal_adaptive_immunity1.39070670
77MP0005360_urolithiasis1.38903200
78MP0003075_altered_response_to1.37900225
79MP0002086_abnormal_extraembryonic_tissu1.37503429
80MP0002085_abnormal_embryonic_tissue1.33707886
81MP0009333_abnormal_splenocyte_physiolog1.33044462
82MP0001929_abnormal_gametogenesis1.30944032
83MP0000343_altered_response_to1.30199773
84MP0002998_abnormal_bone_remodeling1.28096963
85MP0002084_abnormal_developmental_patter1.26121810
86MP0008995_early_reproductive_senescence1.24888657
87MP0000653_abnormal_sex_gland1.24180161
88MP0001293_anophthalmia1.23719411
89MP0003763_abnormal_thymus_physiology1.23396987
90MP0004197_abnormal_fetal_growth/weight/1.20676827
91MP0003448_altered_tumor_morphology1.19213595
92MP0006054_spinal_hemorrhage1.17457597
93MP0003890_abnormal_embryonic-extraembry1.17226880
94MP0004510_myositis1.15270232
95MP0002405_respiratory_system_inflammati1.10216426
96MP0009697_abnormal_copulation1.09963152
97MP0008004_abnormal_stomach_pH1.08635259
98MP0009643_abnormal_urine_homeostasis1.08254390
99MP0001663_abnormal_digestive_system1.08211432
100MP0002254_reproductive_system_inflammat1.05445656
101MP0003121_genomic_imprinting1.04923426
102MP0002398_abnormal_bone_marrow1.03975297
103MP0010329_abnormal_lipoprotein_level1.03891717
104MP0003453_abnormal_keratinocyte_physiol1.03783769
105MP0001119_abnormal_female_reproductive1.03339445
106MP0002138_abnormal_hepatobiliary_system1.01784098
107MP0005085_abnormal_gallbladder_physiolo1.01651783
108MP0000703_abnormal_thymus_morphology1.01645046
109MP0000689_abnormal_spleen_morphology1.01479429
110MP0002722_abnormal_immune_system1.00960765
111MP0004147_increased_porphyrin_level1.00908957
112MP0005319_abnormal_enzyme/_coenzyme0.98479725
113MP0005332_abnormal_amino_acid0.97646342
114MP0005365_abnormal_bile_salt0.97275930
115MP0002160_abnormal_reproductive_system0.96719325
116MP0009278_abnormal_bone_marrow0.95008707
117MP0000465_gastrointestinal_hemorrhage0.93472502
118MP0003186_abnormal_redox_activity0.91858216
119MP0005167_abnormal_blood-brain_barrier0.90637454
120MP0003868_abnormal_feces_composition0.90456442
121MP0009672_abnormal_birth_weight0.88345407
122MP0002136_abnormal_kidney_physiology0.86942664
123MP0003828_pulmonary_edema0.85853395
124MP0002118_abnormal_lipid_homeostasis0.84932999
125MP0004264_abnormal_extraembryonic_tissu0.83002855
126MP0005636_abnormal_mineral_homeostasis0.82918433
127MP0005389_reproductive_system_phenotype0.82903050
128MP0003329_amyloid_beta_deposits0.82270245
129MP0009053_abnormal_anal_canal0.81993409
130MP0003315_abnormal_perineum_morphology0.80958645
131MP0009840_abnormal_foam_cell0.80878854
132MP0005409_darkened_coat_color0.80721888
133MP0005584_abnormal_enzyme/coenzyme_acti0.79792300
134MP0006036_abnormal_mitochondrial_physio0.79737109
135MP0010030_abnormal_orbit_morphology0.79488563
136MP0002429_abnormal_blood_cell0.79352116
137MP0003690_abnormal_glial_cell0.78515213
138MP0001765_abnormal_ion_homeostasis0.77715992
139MP0000358_abnormal_cell_content/0.77409541
140MP0003221_abnormal_cardiomyocyte_apopto0.77261179
141MP0003252_abnormal_bile_duct0.76992603
142MP0001873_stomach_inflammation0.76988283
143MP0005381_digestive/alimentary_phenotyp0.76472069
144MP0001915_intracranial_hemorrhage0.76169457
145MP0002277_abnormal_respiratory_mucosa0.75725018
146MP0000598_abnormal_liver_morphology0.73730045
147MP0000477_abnormal_intestine_morphology0.72830343
148MP0005076_abnormal_cell_differentiation0.72192169
149MP0002796_impaired_skin_barrier0.72190114
150MP0009763_increased_sensitivity_to0.71803912
151MP0001664_abnormal_digestion0.71087232
152MP0003879_abnormal_hair_cell0.70828754
153MP0001853_heart_inflammation0.70396373
154MP0002877_abnormal_melanocyte_morpholog0.68585634
155MP0003699_abnormal_female_reproductive0.68247518
156MP0003698_abnormal_male_reproductive0.66076710
157MP0005075_abnormal_melanosome_morpholog0.65481136
158MP0001764_abnormal_homeostasis0.64902747
159MP0002092_abnormal_eye_morphology0.64901716
160MP0005384_cellular_phenotype0.64502790
161MP0003119_abnormal_digestive_system0.64291806
162MP0005266_abnormal_metabolism0.64245572
163MP0002132_abnormal_respiratory_system0.64050591
164MP0000858_altered_metastatic_potential0.63454791
165MP0003656_abnormal_erythrocyte_physiolo0.63000233
166MP0000716_abnormal_immune_system0.62589805
167MP0005621_abnormal_cell_physiology0.60087887
168MP0003705_abnormal_hypodermis_morpholog0.59725789
169MP0002161_abnormal_fertility/fecundity0.59474457
170MP0009703_decreased_birth_body0.58975990
171MP0000609_abnormal_liver_physiology0.58886799
172MP0005220_abnormal_exocrine_pancreas0.58032834
173MP0003943_abnormal_hepatobiliary_system0.56951062
174MP0002166_altered_tumor_susceptibility0.55427418
175MP0006035_abnormal_mitochondrial_morpho0.53643246

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.59565448
2Abnormality of glycolipid metabolism (HP:0010969)5.07622560
3Abnormality of liposaccharide metabolism (HP:0010968)5.07622560
4Abnormality of glycosphingolipid metabolism (HP:0004343)5.07622560
5Eczematoid dermatitis (HP:0000976)4.67841147
6Abnormality of glutamine family amino acid metabolism (HP:0010902)4.60255795
7Reticulocytopenia (HP:0001896)4.58574776
8Malnutrition (HP:0004395)4.58411745
9Systemic lupus erythematosus (HP:0002725)4.55916594
10Vacuolated lymphocytes (HP:0001922)4.24111574
11Abnormality of macrophages (HP:0004311)4.18685771
12Chromsome breakage (HP:0040012)3.96810798
13Chromosomal breakage induced by crosslinking agents (HP:0003221)3.80721024
14Breast hypoplasia (HP:0003187)3.77311550
15Disinhibition (HP:0000734)3.74560037
16Increased cerebral lipofuscin (HP:0011813)3.69907097
17Recurrent abscess formation (HP:0002722)3.67257812
18Recurrent bacterial skin infections (HP:0005406)3.64877514
19Abnormality of cells of the erythroid lineage (HP:0012130)3.56162262
20Oral leukoplakia (HP:0002745)3.53791471
21Abnormal number of erythroid precursors (HP:0012131)3.52851574
22Abnormality of chromosome stability (HP:0003220)3.47866037
23Loss of speech (HP:0002371)3.43777406
24Colon cancer (HP:0003003)3.39128164
25Chronic diarrhea (HP:0002028)3.39008411
26Abnormality of pyrimidine metabolism (HP:0004353)3.38370703
27Aplastic anemia (HP:0001915)3.32783102
28Impulsivity (HP:0100710)3.31666438
29Abnormality of proline metabolism (HP:0010907)3.24353619
30Hydroxyprolinuria (HP:0003080)3.24353619
31Dysostosis multiplex (HP:0000943)3.23272818
32Medulloblastoma (HP:0002885)3.20844141
33Nausea (HP:0002018)3.19014447
34Selective tooth agenesis (HP:0001592)3.13307938
35Ependymoma (HP:0002888)3.12507170
36Microretrognathia (HP:0000308)3.04377990
37Degeneration of anterior horn cells (HP:0002398)3.02894195
38Abnormality of the anterior horn cell (HP:0006802)3.02894195
39Increased neuronal autofluorescent lipopigment (HP:0002074)3.02809121
40Meckel diverticulum (HP:0002245)3.00268989
41Abnormality of the preputium (HP:0100587)2.95619921
42Rhabdomyosarcoma (HP:0002859)2.94716400
43Recurrent gram-negative bacterial infections (HP:0005420)2.93398134
44Fat malabsorption (HP:0002630)2.87693882
45Patellar aplasia (HP:0006443)2.86199738
46Abnormality of the ileum (HP:0001549)2.86059801
47Orchitis (HP:0100796)2.82160854
48Axonal loss (HP:0003447)2.81772918
49Abnormality of the vasculature of the conjunctiva (HP:0008054)2.81466789
50Aplasia/Hypoplasia of the uvula (HP:0010293)2.80978302
51Absent thumb (HP:0009777)2.80880439
52Widely patent fontanelles and sutures (HP:0004492)2.79219679
53Xanthomatosis (HP:0000991)2.74626207
54Abnormal spermatogenesis (HP:0008669)2.73840405
55Glomerulonephritis (HP:0000099)2.71706716
56Autoimmune thrombocytopenia (HP:0001973)2.70873700
57Absent radius (HP:0003974)2.67844441
58Myelodysplasia (HP:0002863)2.67691311
59Gingivitis (HP:0000230)2.67330495
6011 pairs of ribs (HP:0000878)2.67178019
61Aplasia/Hypoplasia of the patella (HP:0006498)2.63988677
62Supernumerary spleens (HP:0009799)2.59378483
63Petechiae (HP:0000967)2.58585297
64Basal cell carcinoma (HP:0002671)2.57773366
65Carpal bone hypoplasia (HP:0001498)2.57556767
66Myositis (HP:0100614)2.56886944
67Agnosia (HP:0010524)2.55233439
68Metaphyseal irregularity (HP:0003025)2.55167296
69Retrobulbar optic neuritis (HP:0100654)2.49342231
70Optic neuritis (HP:0100653)2.49342231
71Neoplasm of the pancreas (HP:0002894)2.48297487
72Macrocytic anemia (HP:0001972)2.46243729
73Pallor (HP:0000980)2.45016684
74Absent forearm bone (HP:0003953)2.44851389
75Aplasia involving forearm bones (HP:0009822)2.44851389
76Myocardial infarction (HP:0001658)2.41341657
77Duodenal stenosis (HP:0100867)2.41321294
78Small intestinal stenosis (HP:0012848)2.41321294
79Abnormality of DNA repair (HP:0003254)2.40646725
80Premature loss of primary teeth (HP:0006323)2.40533495
81Abnormality of polysaccharide metabolism (HP:0011012)2.40292400
82Abnormality of glycosaminoglycan metabolism (HP:0004371)2.40292400
83Abnormality of mucopolysaccharide metabolism (HP:0011020)2.40292400
84Mucopolysacchariduria (HP:0008155)2.39899154
85Urinary glycosaminoglycan excretion (HP:0003541)2.39899154
86Mediastinal lymphadenopathy (HP:0100721)2.39599924
87Spontaneous hematomas (HP:0007420)2.38269893
88Abnormality of the vitamin B12 metabolism (HP:0004341)2.33985726
89Mutism (HP:0002300)2.33244415
90Acanthocytosis (HP:0001927)2.32928083
91Proximal placement of thumb (HP:0009623)2.30394773
92Hyperactive renin-angiotensin system (HP:0000841)2.29798672
93Thin bony cortex (HP:0002753)2.28269389
94Hypophosphatemia (HP:0002148)2.27750601
95Bone marrow hypocellularity (HP:0005528)2.25946235
96Hypobetalipoproteinemia (HP:0003563)2.24908733
97Ileus (HP:0002595)2.24842488
98Rough bone trabeculation (HP:0100670)2.23088350
99Abnormal number of incisors (HP:0011064)2.22374110
100Abnormality of vitamin B metabolism (HP:0004340)2.21573251
101IgM deficiency (HP:0002850)2.21181951
102Abnormality of reticulocytes (HP:0004312)2.20750772
103Horseshoe kidney (HP:0000085)2.18746338
104Abnormality of the costochondral junction (HP:0000919)2.18585420
105Azoospermia (HP:0000027)2.18474846
106Biliary tract neoplasm (HP:0100574)2.15144026
107Chronic obstructive pulmonary disease (HP:0006510)2.14381169
108Obstructive lung disease (HP:0006536)2.14381169
109Abnormality of the duodenum (HP:0002246)2.14029028
110Abnormality of the heme biosynthetic pathway (HP:0010472)2.13693112
111Encephalitis (HP:0002383)2.13535717
112Deviation of the thumb (HP:0009603)2.12385284
113Steatorrhea (HP:0002570)2.12190690
114Recurrent skin infections (HP:0001581)2.11845361
115Metabolic alkalosis (HP:0200114)2.11701957
116Pancytopenia (HP:0001876)2.11642839
117Neoplasm of striated muscle (HP:0009728)2.11104003
118Purpura (HP:0000979)2.10610787
119Abdominal distention (HP:0003270)2.10525275
120Bone pain (HP:0002653)2.10372964
121Complement deficiency (HP:0004431)2.10162902
122Slender long bone (HP:0003100)2.09955546
123Abnormality of the carotid arteries (HP:0005344)2.09572630
124Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.09285309
125Amaurosis fugax (HP:0100576)2.09194105
126Neoplasm of the colon (HP:0100273)2.08944148
127Peripheral demyelination (HP:0011096)2.07267911
128Vasculitis (HP:0002633)2.07010533
129Conjunctival telangiectasia (HP:0000524)2.06783616
130Hematochezia (HP:0002573)2.06558791
131Tracheoesophageal fistula (HP:0002575)2.04877837
132Ectopic kidney (HP:0000086)2.04650651
133Intrahepatic cholestasis (HP:0001406)2.03437514
134Hepatosplenomegaly (HP:0001433)2.02175162
135Sloping forehead (HP:0000340)2.00381319
136Premature graying of hair (HP:0002216)2.00371851
137Cafe-au-lait spot (HP:0000957)2.00298705
138Neurofibrillary tangles (HP:0002185)1.99939535
139Duplicated collecting system (HP:0000081)1.99059951
140Squamous cell carcinoma (HP:0002860)1.98636575
141Stomatitis (HP:0010280)1.98575387
142Abnormality of vitamin metabolism (HP:0100508)1.98309854
143Urticaria (HP:0001025)1.97415648
144Missing ribs (HP:0000921)1.97163220
145Increased nuchal translucency (HP:0010880)1.96363556
146Progressive muscle weakness (HP:0003323)1.96353741
147Megaloblastic anemia (HP:0001889)1.95346913
148Flat acetabular roof (HP:0003180)1.94574163
149Amyloidosis (HP:0011034)1.94376449
150T lymphocytopenia (HP:0005403)1.94370289
151Prominent nose (HP:0000448)1.93493474
152Hypochromic anemia (HP:0001931)1.93102727
153Abnormality of alkaline phosphatase activity (HP:0004379)1.93028828
154Increased IgM level (HP:0003496)1.93019374
155Abnormal biliary tract morphology (HP:0012440)1.91907077
156Lymphoma (HP:0002665)1.91596783
157Abnormal enzyme/coenzyme activity (HP:0012379)1.91475658
158Neoplasm of the rectum (HP:0100743)1.90175498
159Recurrent fungal infections (HP:0002841)1.89973677
160Elevated alkaline phosphatase (HP:0003155)1.89867250
161Facial hemangioma (HP:0000329)1.89293736
162Triphalangeal thumb (HP:0001199)1.88955671
163Neoplasm of the oral cavity (HP:0100649)1.88526141
164Reduced antithrombin III activity (HP:0001976)1.88451600
165Abnormality of T cell number (HP:0011839)1.88258887
166Inappropriate behavior (HP:0000719)1.87968559
167Progressive neurologic deterioration (HP:0002344)1.87698127
168Poikiloderma (HP:0001029)1.87389696
169Cellular immunodeficiency (HP:0005374)1.87151174
170Hyperparathyroidism (HP:0000843)1.86142336
171Clubbing of toes (HP:0100760)1.85863637
172Glioma (HP:0009733)1.85508019
173Pulmonary infiltrates (HP:0002113)1.85376810
174Atrophy/Degeneration involving motor neurons (HP:0007373)1.85265170
175Asplenia (HP:0001746)1.84671832
176Thrombocytosis (HP:0001894)1.84558017
177Hemoptysis (HP:0002105)1.84208743
178Pathologic fracture (HP:0002756)1.84019622
179Abnormal lung lobation (HP:0002101)1.83920172
180Hypolipoproteinemia (HP:0010981)1.83572750
181Abnormality of complement system (HP:0005339)1.83542112
182Symptomatic seizures (HP:0011145)1.83140010
183Abnormality of the renal collecting system (HP:0004742)1.83127047
184Volvulus (HP:0002580)1.82522457
185Meningitis (HP:0001287)1.82161158
186Atresia of the external auditory canal (HP:0000413)1.82156984
187Protuberant abdomen (HP:0001538)1.81802685
188Acute myeloid leukemia (HP:0004808)1.81378902
189Osteomyelitis (HP:0002754)1.81254511
190Dementia (HP:0000726)1.80778966
191Proximal tubulopathy (HP:0000114)1.80615083
192Astrocytoma (HP:0009592)1.79958624
193Abnormality of the astrocytes (HP:0100707)1.79958624
194Spastic diplegia (HP:0001264)1.77282247
195Overlapping toe (HP:0001845)1.76670489
196Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.76293319
197Abnormality of monocarboxylic acid metabolism (HP:0010996)1.75810950

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.61938467
2WEE14.50733506
3BUB14.03266927
4NEK23.71402828
5ERN13.57662002
6RIPK43.32375466
7IRAK32.80624565
8NEK12.76951910
9RIPK12.64941061
10MAP3K142.63204213
11BRSK22.54785557
12EIF2AK12.39676563
13SRPK12.39189630
14FGR2.31252444
15TTK2.31232463
16DYRK32.21206464
17CSK2.19418851
18STK162.16365357
19TAOK12.06516345
20PRPF4B2.03034865
21PLK12.02936721
22* ACVR1B1.98954293
23IRAK41.98056644
24BLK1.96418186
25EIF2AK31.93173523
26RPS6KA41.89042501
27ATR1.87537405
28MKNK11.87135948
29CDK71.86821653
30CDK121.86266910
31TBK11.85731800
32PRKG21.85684265
33NME21.85415301
34AURKB1.80051851
35GRK71.79251404
36MST41.78924455
37MAP3K11.75287339
38DDR21.70289688
39CDK41.69618329
40MAP3K31.67398404
41VRK11.65814201
42EEF2K1.60986888
43MAP3K21.59158919
44RPS6KB21.59008383
45PASK1.57045220
46BRSK11.53402501
47MKNK21.53230511
48SCYL21.53037027
49TESK21.50758869
50CHEK21.48602356
51PLK41.46741620
52TGFBR21.46671849
53KSR21.46647510
54FLT31.44221187
55TSSK61.37366825
56TGFBR11.35144103
57IKBKE1.32219443
58MST1R1.30955085
59CDK81.29874909
60TXK1.29293272
61CCNB11.24930668
62BMPR21.22075458
63CHEK11.21561084
64TLK11.21496354
65IRAK11.21074656
66PLK31.20325998
67MAP3K131.19604937
68ZAP701.17394288
69PIM11.15921100
70MAP3K101.15875267
71PDK21.13503002
72PBK1.12744077
73MAP3K81.10341417
74STK101.06979934
75LYN1.05440462
76CDC42BPA1.05306992
77JAK21.04430922
78ABL21.04247976
79AURKA1.03881865
80IKBKB1.01533411
81STK41.00720719
82JAK10.99194275
83MAP3K120.98226005
84SYK0.97235111
85ATM0.96325646
86IRAK20.94827740
87FGFR40.91548035
88CDK20.90676975
89FGFR30.90635711
90PTK60.88933610
91CDK60.87992454
92PAK40.87861317
93CAMKK20.87337766
94CDK190.85402303
95BCKDK0.84984036
96EPHB10.84424208
97MAPKAPK30.83109882
98TESK10.82714383
99MAP3K50.82427187
100PDPK10.78159509
101MAP2K60.77437287
102PKN20.76689900
103BRD40.76568362
104MAP4K10.75298887
105STK30.74163953
106CSNK2A20.70805516
107LCK0.70628601
108HCK0.70220639
109MELK0.68545882
110MAP2K30.68378639
111PDK10.67094034
112OXSR10.66013643
113CSNK2A10.64366276
114CDK10.62950205
115FES0.62601787
116EPHA20.60867331
117MATK0.60502966
118KSR10.60445977
119NEK90.59909948
120RPS6KA50.59903213
121BTK0.58969139
122MAPK110.58069511
123ZAK0.57478030
124PIM20.57418484
125DYRK1B0.56574983
126KDR0.56119795
127BMX0.54431969
128GRK60.54107672
129ITK0.53597101
130LRRK20.46418282
131PAK10.46292401
132STK38L0.44354588
133STK390.44238743
134RAF10.43837345
135TEC0.43828325
136PRKAA20.42218976
137FYN0.41881167
138MTOR0.41728287
139MAP2K20.41152479
140EIF2AK20.40997564
141ARAF0.40367675
142TYK20.39695197
143PIK3CA0.38780059
144KIT0.38081157
145CLK10.36961923
146SIK30.36903092
147DYRK20.36774279
148PRKCI0.35832709
149PRKACG0.35689764
150PDK40.35604566
151PDK30.35604566
152CSF1R0.33848938
153ALK0.33829959
154AKT20.33428452
155PRKCD0.33271217
156MAP3K60.31623922
157EPHA30.31485458
158TAOK20.31251464
159JAK30.31128616
160DAPK10.30491968
161TAOK30.30008140
162MAPKAPK20.29560844
163YES10.29502986
164MARK30.29128311
165STK240.28763291
166PRKDC0.28558802
167CDK90.27135391
168CHUK0.23460094
169MAPK140.21803413
170NLK0.21618288
171BRAF0.21548119
172MAP3K110.20995436

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.24329645
2Mismatch repair_Homo sapiens_hsa034304.39614021
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.45005062
4Base excision repair_Homo sapiens_hsa034103.09600577
5Spliceosome_Homo sapiens_hsa030403.01654588
6Homologous recombination_Homo sapiens_hsa034403.00111571
7Nucleotide excision repair_Homo sapiens_hsa034202.87305539
8Other glycan degradation_Homo sapiens_hsa005112.82557687
9Cell cycle_Homo sapiens_hsa041102.80372130
10RNA transport_Homo sapiens_hsa030132.79428999
11RNA polymerase_Homo sapiens_hsa030202.78569181
12One carbon pool by folate_Homo sapiens_hsa006702.78441252
13Ribosome_Homo sapiens_hsa030102.71452878
14Pyrimidine metabolism_Homo sapiens_hsa002402.41892523
15Staphylococcus aureus infection_Homo sapiens_hsa051502.40789124
16Mineral absorption_Homo sapiens_hsa049782.37336923
17Proteasome_Homo sapiens_hsa030502.28017005
18Fanconi anemia pathway_Homo sapiens_hsa034602.27615922
19Lysosome_Homo sapiens_hsa041422.05905744
20Sulfur metabolism_Homo sapiens_hsa009202.04059474
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.98746521
22Leishmaniasis_Homo sapiens_hsa051401.97345609
23Basal transcription factors_Homo sapiens_hsa030221.93516777
24Non-homologous end-joining_Homo sapiens_hsa034501.87450067
25Allograft rejection_Homo sapiens_hsa053301.84966585
26RNA degradation_Homo sapiens_hsa030181.76923206
27Osteoclast differentiation_Homo sapiens_hsa043801.75847848
28Graft-versus-host disease_Homo sapiens_hsa053321.72514966
29mRNA surveillance pathway_Homo sapiens_hsa030151.69867797
30Asthma_Homo sapiens_hsa053101.64173243
31Rheumatoid arthritis_Homo sapiens_hsa053231.62314984
32Starch and sucrose metabolism_Homo sapiens_hsa005001.61250235
33p53 signaling pathway_Homo sapiens_hsa041151.60172020
34PPAR signaling pathway_Homo sapiens_hsa033201.59576136
35Selenocompound metabolism_Homo sapiens_hsa004501.58993732
36Autoimmune thyroid disease_Homo sapiens_hsa053201.53609579
37Folate biosynthesis_Homo sapiens_hsa007901.49478935
38Tuberculosis_Homo sapiens_hsa051521.47812918
39Toll-like receptor signaling pathway_Homo sapiens_hsa046201.44084945
40Drug metabolism - other enzymes_Homo sapiens_hsa009831.41171731
41Cyanoamino acid metabolism_Homo sapiens_hsa004601.40768861
42Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.36003796
43Type I diabetes mellitus_Homo sapiens_hsa049401.31924766
44Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.31085354
45Systemic lupus erythematosus_Homo sapiens_hsa053221.28617766
46NF-kappa B signaling pathway_Homo sapiens_hsa040641.25388041
47Pertussis_Homo sapiens_hsa051331.25316144
48Histidine metabolism_Homo sapiens_hsa003401.24645627
49Purine metabolism_Homo sapiens_hsa002301.20669985
50Carbohydrate digestion and absorption_Homo sapiens_hsa049731.18262796
51NOD-like receptor signaling pathway_Homo sapiens_hsa046211.17432143
52Glycosaminoglycan degradation_Homo sapiens_hsa005311.16804145
53Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.13016298
54Pentose phosphate pathway_Homo sapiens_hsa000301.11762026
55Cysteine and methionine metabolism_Homo sapiens_hsa002701.10553951
56Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.06633735
57Biosynthesis of amino acids_Homo sapiens_hsa012301.05942094
58TNF signaling pathway_Homo sapiens_hsa046681.04256319
59Retinol metabolism_Homo sapiens_hsa008301.03125330
60Phagosome_Homo sapiens_hsa041451.03065286
61Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.98487871
62Protein digestion and absorption_Homo sapiens_hsa049740.98441295
63Sphingolipid metabolism_Homo sapiens_hsa006000.97484492
64Hematopoietic cell lineage_Homo sapiens_hsa046400.96870042
65Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.96792098
66Salmonella infection_Homo sapiens_hsa051320.96753670
67Herpes simplex infection_Homo sapiens_hsa051680.94748074
68Toxoplasmosis_Homo sapiens_hsa051450.92683590
69Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.91521731
70Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.90218843
71Epstein-Barr virus infection_Homo sapiens_hsa051690.89613204
72Hepatitis C_Homo sapiens_hsa051600.89262677
73B cell receptor signaling pathway_Homo sapiens_hsa046620.88776507
74Antigen processing and presentation_Homo sapiens_hsa046120.88224657
75Viral carcinogenesis_Homo sapiens_hsa052030.86509175
76Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.84902082
77Malaria_Homo sapiens_hsa051440.84753568
78Arachidonic acid metabolism_Homo sapiens_hsa005900.84262603
79Steroid hormone biosynthesis_Homo sapiens_hsa001400.83363077
80Oocyte meiosis_Homo sapiens_hsa041140.81211258
81RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.81055677
82Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.81032692
83Chemokine signaling pathway_Homo sapiens_hsa040620.81015821
84Vitamin B6 metabolism_Homo sapiens_hsa007500.80761597
85Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.80324631
86Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.80039304
87Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.78284849
88Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.77047168
89Sulfur relay system_Homo sapiens_hsa041220.76490918
90Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.75880322
91Bile secretion_Homo sapiens_hsa049760.73653538
92Glycerolipid metabolism_Homo sapiens_hsa005610.71739790
93Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.70956994
94African trypanosomiasis_Homo sapiens_hsa051430.70566292
95Collecting duct acid secretion_Homo sapiens_hsa049660.69131633
96Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.68219549
97Complement and coagulation cascades_Homo sapiens_hsa046100.67058073
98Glutathione metabolism_Homo sapiens_hsa004800.66981869
99Carbon metabolism_Homo sapiens_hsa012000.66653537
100Thyroid cancer_Homo sapiens_hsa052160.63016735
101HTLV-I infection_Homo sapiens_hsa051660.62988982
102Viral myocarditis_Homo sapiens_hsa054160.61919576
103Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.61833357
104Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.60417440
105Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.60352349
106Ether lipid metabolism_Homo sapiens_hsa005650.58438328
107Caffeine metabolism_Homo sapiens_hsa002320.56538265
108Legionellosis_Homo sapiens_hsa051340.54438884
109Transcriptional misregulation in cancer_Homo sapiens_hsa052020.53064088
110Leukocyte transendothelial migration_Homo sapiens_hsa046700.52147956
111alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.49861299
112Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.49371973
113Lysine degradation_Homo sapiens_hsa003100.49238260
114Linoleic acid metabolism_Homo sapiens_hsa005910.48349506
115Small cell lung cancer_Homo sapiens_hsa052220.48238589
116Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.47873512
117MicroRNAs in cancer_Homo sapiens_hsa052060.44930457
1182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.44712310
119Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.42631650
120Adipocytokine signaling pathway_Homo sapiens_hsa049200.41494159
121Vibrio cholerae infection_Homo sapiens_hsa051100.40743726
122Vitamin digestion and absorption_Homo sapiens_hsa049770.40044225
123Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.38685986
124Primary immunodeficiency_Homo sapiens_hsa053400.37614658
125Glycerophospholipid metabolism_Homo sapiens_hsa005640.36981917
126Primary bile acid biosynthesis_Homo sapiens_hsa001200.36774560
127Jak-STAT signaling pathway_Homo sapiens_hsa046300.36764384
128T cell receptor signaling pathway_Homo sapiens_hsa046600.36428678
129Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.36420110
130N-Glycan biosynthesis_Homo sapiens_hsa005100.34768452
131Alcoholism_Homo sapiens_hsa050340.34144937
132Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.33671585
133Maturity onset diabetes of the young_Homo sapiens_hsa049500.33077974
134Pentose and glucuronate interconversions_Homo sapiens_hsa000400.32901479
135Hepatitis B_Homo sapiens_hsa051610.32523564
136Galactose metabolism_Homo sapiens_hsa000520.31535758
137Apoptosis_Homo sapiens_hsa042100.31368601
138Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.30214575
139Renin-angiotensin system_Homo sapiens_hsa046140.30204542
140Protein export_Homo sapiens_hsa030600.29659185
141TGF-beta signaling pathway_Homo sapiens_hsa043500.27192472
142Colorectal cancer_Homo sapiens_hsa052100.26512498
143Metabolic pathways_Homo sapiens_hsa011000.26359935
144Bladder cancer_Homo sapiens_hsa052190.25124669
145Fructose and mannose metabolism_Homo sapiens_hsa000510.24669137
146Arginine biosynthesis_Homo sapiens_hsa002200.24267504
147Pyruvate metabolism_Homo sapiens_hsa006200.22707098
148Peroxisome_Homo sapiens_hsa041460.22565723
149Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.22360732
150Measles_Homo sapiens_hsa051620.19828229
151Arginine and proline metabolism_Homo sapiens_hsa003300.18725136
152Influenza A_Homo sapiens_hsa051640.18024830
153Fat digestion and absorption_Homo sapiens_hsa049750.17868444
154Tryptophan metabolism_Homo sapiens_hsa003800.17178749
155Central carbon metabolism in cancer_Homo sapiens_hsa052300.16276708
156Chemical carcinogenesis_Homo sapiens_hsa052040.16114546
157Shigellosis_Homo sapiens_hsa051310.15190105
158Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.14857558
159Fatty acid degradation_Homo sapiens_hsa000710.14849099
160beta-Alanine metabolism_Homo sapiens_hsa004100.14242990
161Intestinal immune network for IgA production_Homo sapiens_hsa046720.12496037
162Acute myeloid leukemia_Homo sapiens_hsa052210.12159946
163Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.11410160
164Chronic myeloid leukemia_Homo sapiens_hsa052200.11293587

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