TDRD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is similar to a mouse gene that encodes a tudor domain protein. Alternatively spliced transcript variants have been described but their full length sequences have not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* DNA methylation involved in gamete generation (GO:0043046)9.74887936
2fusion of sperm to egg plasma membrane (GO:0007342)8.42131665
3multicellular organism reproduction (GO:0032504)8.26719057
4regulation of meiosis I (GO:0060631)7.91950283
5male meiosis I (GO:0007141)7.60263214
6axonemal dynein complex assembly (GO:0070286)7.47875215
7sperm-egg recognition (GO:0035036)7.34557663
8binding of sperm to zona pellucida (GO:0007339)7.29438083
9chromosome organization involved in meiosis (GO:0070192)7.22515433
10meiotic nuclear division (GO:0007126)7.19779268
11sperm motility (GO:0030317)6.76398351
12acrosome assembly (GO:0001675)6.68581451
13cell-cell recognition (GO:0009988)6.51458858
14reproduction (GO:0000003)6.38950261
15spermatid development (GO:0007286)6.37697845
16plasma membrane fusion (GO:0045026)6.36285934
17meiosis I (GO:0007127)6.28840597
18epithelial cilium movement (GO:0003351)6.28694073
19epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.14935177
20motile cilium assembly (GO:0044458)6.03717648
21regulation of DNA methylation (GO:0044030)5.89680225
22cilium movement (GO:0003341)5.78460039
23fertilization (GO:0009566)5.62071371
24* gene silencing by RNA (GO:0031047)5.57948278
25* meiotic cell cycle (GO:0051321)5.56665640
26single fertilization (GO:0007338)5.44032975
27acrosome reaction (GO:0007340)5.16180630
28meiotic cell cycle process (GO:1903046)5.04892106
29regulation of steroid hormone secretion (GO:2000831)5.01785213
30retinal cone cell development (GO:0046549)4.96339803
31positive regulation of transcription from RNA polymerase III promoter (GO:0045945)4.95825276
32negative regulation of reproductive process (GO:2000242)4.88767637
33* DNA alkylation (GO:0006305)4.82142550
34* DNA methylation (GO:0006306)4.82142550
35positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.81569676
36monoubiquitinated protein deubiquitination (GO:0035520)4.69227096
37* spermatogenesis (GO:0007283)4.63017364
38* male gamete generation (GO:0048232)4.62068218
39* germ cell development (GO:0007281)4.60945338
40nuclear pore complex assembly (GO:0051292)4.59126085
41protein kinase C signaling (GO:0070528)4.52017661
42branching involved in prostate gland morphogenesis (GO:0060442)4.47604986
43* gamete generation (GO:0007276)4.46576051
44regulation of cilium movement (GO:0003352)4.43826471
45oogenesis (GO:0048477)4.41105543
46positive regulation of histone H3-K4 methylation (GO:0051571)4.40956357
47* cellular process involved in reproduction in multicellular organism (GO:0022412)4.39930433
48female gamete generation (GO:0007292)4.36455327
49biotin metabolic process (GO:0006768)4.32816586
50positive regulation of steroid hormone secretion (GO:2000833)4.30669613
51negative regulation of meiosis (GO:0045835)4.27326049
52regulation of centriole replication (GO:0046599)4.12579235
53positive regulation of meiosis (GO:0045836)4.12404051
54androgen receptor signaling pathway (GO:0030521)4.09591962
55synapsis (GO:0007129)4.07310622
56nuclear pore organization (GO:0006999)4.00187641
57negative regulation of histone methylation (GO:0031061)3.98098037
58negative regulation of inclusion body assembly (GO:0090084)3.97753101
59sister chromatid cohesion (GO:0007062)3.97393423
60microtubule depolymerization (GO:0007019)3.94866941
61cell wall macromolecule metabolic process (GO:0044036)3.94679350
62cell wall macromolecule catabolic process (GO:0016998)3.94679350
63positive regulation of meiotic cell cycle (GO:0051446)3.93449467
64meiotic chromosome segregation (GO:0045132)3.93230490
65microtubule severing (GO:0051013)3.92269023
66positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)3.91749510
67regulation of meiosis (GO:0040020)3.91710823
68mitotic chromosome condensation (GO:0007076)3.89110242
69genitalia morphogenesis (GO:0035112)3.82643814
70regulation of acrosome reaction (GO:0060046)3.79943637
71* gene silencing (GO:0016458)3.79567820
72seminiferous tubule development (GO:0072520)3.75418252
73regulation of phospholipid biosynthetic process (GO:0071071)3.75000851
74regulation of histone H3-K4 methylation (GO:0051569)3.74514570
75Golgi to endosome transport (GO:0006895)3.70462626
76mitotic sister chromatid cohesion (GO:0007064)3.67863591
77artery development (GO:0060840)3.67043411
78* DNA methylation or demethylation (GO:0044728)3.58980505
79sperm capacitation (GO:0048240)3.55779760
80centriole replication (GO:0007099)3.55748346
81pore complex assembly (GO:0046931)3.50979750
82ventricular system development (GO:0021591)3.47510692
83* multicellular organismal reproductive process (GO:0048609)3.47504559
84N-terminal protein amino acid acetylation (GO:0006474)3.45211758
85regulation of female gonad development (GO:2000194)3.40807343
86regulation of protein polyubiquitination (GO:1902914)3.40343086
87oocyte development (GO:0048599)3.39564799
88regulation of histone H3-K9 methylation (GO:0051570)3.38671218
89protein localization to cilium (GO:0061512)3.37286952
90reciprocal DNA recombination (GO:0035825)3.36202409
91reciprocal meiotic recombination (GO:0007131)3.36202409
92negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.34941756
93mitotic sister chromatid segregation (GO:0000070)3.32363349
94positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.31193049
95positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.31193049
96positive regulation of mitotic sister chromatid separation (GO:1901970)3.31193049
97histone exchange (GO:0043486)3.30871386
98epithelial cell maturation (GO:0002070)3.28932259
99intraciliary transport (GO:0042073)3.25530800
100negative regulation of organelle assembly (GO:1902116)3.25523204
101regulation of calcium ion-dependent exocytosis (GO:0017158)3.25440824
102attachment of spindle microtubules to kinetochore (GO:0008608)3.22437073
103regulation of histone methylation (GO:0031060)3.22023570
104protein polyglutamylation (GO:0018095)3.21223699
105intestinal epithelial cell development (GO:0060576)3.20565018
106regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.19256204
107phosphorelay signal transduction system (GO:0000160)3.18735812
108regulation of cell maturation (GO:1903429)3.17749544
109positive regulation of histone methylation (GO:0031062)3.15211721
110regulation of meiotic cell cycle (GO:0051445)3.13544570
111protein localization to chromosome, centromeric region (GO:0071459)3.12927572
112oocyte maturation (GO:0001556)3.08961350
113negative regulation of DNA repair (GO:0045738)3.04956603
114sex differentiation (GO:0007548)3.03068902
115protein K6-linked ubiquitination (GO:0085020)3.02921694
116prostate gland epithelium morphogenesis (GO:0060740)3.01692191
117regulation of receptor binding (GO:1900120)3.00453547
118centriole assembly (GO:0098534)2.98503206
119regulation of spindle checkpoint (GO:0090231)2.97693409
120* DNA modification (GO:0006304)2.97413031
121cellular response to gamma radiation (GO:0071480)2.97231452
122DNA packaging (GO:0006323)2.97041294
123positive regulation of cellular amine metabolic process (GO:0033240)2.96877852
124nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.96800809
125cell recognition (GO:0008037)2.96219294
126regulation of centrosome cycle (GO:0046605)2.92816861
127DNA replication-dependent nucleosome organization (GO:0034723)2.91599196
128DNA replication-dependent nucleosome assembly (GO:0006335)2.91599196
129nucleus organization (GO:0006997)2.91512833
130replicative senescence (GO:0090399)2.91022981
131histone H3-K4 trimethylation (GO:0080182)2.89956402
132histone H3-K4 methylation (GO:0051568)2.89332997
133opsonization (GO:0008228)2.85969880
134lung epithelial cell differentiation (GO:0060487)2.85171384
135positive regulation of reproductive process (GO:2000243)2.84257081
136glycine transport (GO:0015816)2.82970869
137negative regulation of histone modification (GO:0031057)2.81995201
138prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.80620147
139regulation of reproductive process (GO:2000241)2.78617118
140histone H3-K9 demethylation (GO:0033169)2.74159725
141lung cell differentiation (GO:0060479)2.72792994
142positive regulation of humoral immune response (GO:0002922)2.72540994
143regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.70647938
144negative regulation of cAMP-mediated signaling (GO:0043951)2.65225679
145positive regulation of gastrulation (GO:2000543)2.64833829
146regulation of transcription from RNA polymerase III promoter (GO:0006359)2.64334055
147positive regulation of chromosome segregation (GO:0051984)2.62153333
148translesion synthesis (GO:0019985)2.57245043
149mitotic cell cycle arrest (GO:0071850)2.57170933
150regulation of chromatin silencing (GO:0031935)2.55854636
151negative regulation of chromatin modification (GO:1903309)2.55670206
152* piRNA metabolic process (GO:0034587)14.2630681
153male meiosis (GO:0007140)11.5586445
154cilium or flagellum-dependent cell motility (GO:0001539)11.4471693
155synaptonemal complex organization (GO:0070193)10.1367876
156synaptonemal complex assembly (GO:0007130)10.1018650

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.52776055
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.83790914
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.69954500
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.48264157
5PIAS1_25552417_ChIP-Seq_VCAP_Human3.08960126
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.05829352
7FOXM1_23109430_ChIP-Seq_U2OS_Human2.94539427
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.50919528
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.49445495
10TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.32550606
11* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.27806413
12GATA1_26923725_Chip-Seq_HPCs_Mouse2.26552357
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.23058369
14PCGF2_27294783_Chip-Seq_ESCs_Mouse2.20048116
15ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.17346789
16E2F7_22180533_ChIP-Seq_HELA_Human2.17011513
17ESR1_20079471_ChIP-ChIP_T-47D_Human2.13674991
18FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.10092019
19MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse10.3951669
20PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.96921980
21ZNF217_24962896_ChIP-Seq_MCF-7_Human1.94460841
22* KAP1_22055183_ChIP-Seq_ESCs_Mouse1.92514558
23GBX2_23144817_ChIP-Seq_PC3_Human1.89917108
24* FOXA1_25552417_ChIP-Seq_VCAP_Human1.82960460
25NOTCH1_21737748_ChIP-Seq_TLL_Human1.82889315
26ER_23166858_ChIP-Seq_MCF-7_Human1.81554299
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.80605899
28RNF2_27304074_Chip-Seq_NSC_Mouse1.79424201
29KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.78696786
30KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.78696786
31KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.78696786
32AR_25329375_ChIP-Seq_VCAP_Human1.77708146
33ELK4_26923725_Chip-Seq_MESODERM_Mouse1.76323637
34FOXM1_26456572_ChIP-Seq_MCF-7_Human1.67443558
35AHR_22903824_ChIP-Seq_MCF-7_Human1.63528793
36NFE2_27457419_Chip-Seq_LIVER_Mouse1.63432393
37E2F4_17652178_ChIP-ChIP_JURKAT_Human1.61224790
38PKCTHETA_26484144_Chip-Seq_BREAST_Human1.59149177
39TP63_19390658_ChIP-ChIP_HaCaT_Human1.58892121
40AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.56230789
41SUZ12_27294783_Chip-Seq_NPCs_Mouse1.56198992
42FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.52874521
43KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.50868429
44STAT6_21828071_ChIP-Seq_BEAS2B_Human1.46678108
45PCGF2_27294783_Chip-Seq_NPCs_Mouse1.46388297
46GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44523902
47SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.43282148
48ERG_20517297_ChIP-Seq_VCAP_Human1.41802514
49STAT1_17558387_ChIP-Seq_HELA_Human1.41333265
50PADI4_21655091_ChIP-ChIP_MCF-7_Human1.41105345
51ARNT_22903824_ChIP-Seq_MCF-7_Human1.40341673
52RUNX1_26923725_Chip-Seq_HPCs_Mouse1.39872721
53KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.38470990
54* AR_21909140_ChIP-Seq_LNCAP_Human1.38141089
55RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.37334290
56RBPJ_22232070_ChIP-Seq_NCS_Mouse1.35460214
57HTT_18923047_ChIP-ChIP_STHdh_Human1.34153841
58AR_20517297_ChIP-Seq_VCAP_Human1.33057511
59MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.32994038
60AR_21572438_ChIP-Seq_LNCaP_Human1.32742561
61EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.32712887
62TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.31926413
63TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28948334
64POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.28948334
65CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.28513082
66TOP2B_26459242_ChIP-Seq_MCF-7_Human1.27662826
67SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.27255891
68TP53_22573176_ChIP-Seq_HFKS_Human1.26558077
69SMAD4_21799915_ChIP-Seq_A2780_Human1.25141516
70PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24785990
71TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.24664927
72* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.24121247
73ZNF274_21170338_ChIP-Seq_K562_Hela1.24049526
74EWS_26573619_Chip-Seq_HEK293_Human1.23169976
75CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.22909967
76EZH2_27294783_Chip-Seq_NPCs_Mouse1.22517935
77TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.22446978
78WDR5_24793694_ChIP-Seq_LNCAP_Human1.22153958
79MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.19885517
80NANOG_18555785_Chip-Seq_ESCs_Mouse1.19697520
81RUNX2_22187159_ChIP-Seq_PCA_Human1.19337216
82CTBP2_25329375_ChIP-Seq_LNCAP_Human1.19090105
83P300_19829295_ChIP-Seq_ESCs_Human1.18172661
84TCF4_23295773_ChIP-Seq_U87_Human1.16896541
85ELF5_23300383_ChIP-Seq_T47D_Human1.16273773
86OCT4_18555785_Chip-Seq_ESCs_Mouse1.16213743
87FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15971651
88KDM5A_27292631_Chip-Seq_BREAST_Human1.15919835
89BMI1_23680149_ChIP-Seq_NPCS_Mouse1.15813596
90AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.15571082
91EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.15389183
92RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.14475631
93STAT3_18555785_Chip-Seq_ESCs_Mouse1.14238266
94TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.12372690
95EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.11841909
96TAL1_26923725_Chip-Seq_HPCs_Mouse1.11620931
97* ESR2_21235772_ChIP-Seq_MCF-7_Human1.10864131
98ESR1_15608294_ChIP-ChIP_MCF-7_Human1.10799343
99UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.10338562
100HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.09523345
101OCT1_27270436_Chip-Seq_PROSTATE_Human1.09502981
102TAF15_26573619_Chip-Seq_HEK293_Human1.07416814
103ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.07181068
104* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.07099296
105ESRRB_18555785_Chip-Seq_ESCs_Mouse1.06684543
106CTBP1_25329375_ChIP-Seq_LNCAP_Human1.06642740
107CDX2_22108803_ChIP-Seq_LS180_Human1.06304696
108KLF4_18555785_Chip-Seq_ESCs_Mouse1.06168296
109GATA3_21867929_ChIP-Seq_TH1_Mouse1.06015772
110BCAT_22108803_ChIP-Seq_LS180_Human1.05461160
111IGF1R_20145208_ChIP-Seq_DFB_Human1.05251696
112CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.05181270
113CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.05136173
114SMAD4_21741376_ChIP-Seq_EPCs_Human1.04499727
115FUS_26573619_Chip-Seq_HEK293_Human1.03890801
116EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.02352362
117POU3F2_20337985_ChIP-ChIP_501MEL_Human1.02307440
118IRF1_19129219_ChIP-ChIP_H3396_Human1.01761570
119STAT3_23295773_ChIP-Seq_U87_Human1.01194714
120SMAD3_21741376_ChIP-Seq_EPCs_Human1.01035350
121GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.00507272
122* KDM2B_26808549_Chip-Seq_REH_Human0.99826008
123GATA3_21878914_ChIP-Seq_MCF-7_Human0.99699176
124CRX_20693478_ChIP-Seq_RETINA_Mouse0.99595820
125TBL1_22424771_ChIP-Seq_293T_Human0.99212689
126GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.98902887
127P53_22387025_ChIP-Seq_ESCs_Mouse0.97552208
128HOXB7_26014856_ChIP-Seq_BT474_Human0.96870277
129OCT4_21477851_ChIP-Seq_ESCs_Mouse0.96687756
130CBX2_27304074_Chip-Seq_ESCs_Mouse0.96474271
131P300_18555785_Chip-Seq_ESCs_Mouse0.95518714
132FOXA1_25329375_ChIP-Seq_VCAP_Human0.95332792
133FOXA1_27270436_Chip-Seq_PROSTATE_Human0.95332792
134PRDM14_20953172_ChIP-Seq_ESCs_Human0.95248083
135ZFX_18555785_Chip-Seq_ESCs_Mouse0.95180694
136E2F1_18555785_Chip-Seq_ESCs_Mouse0.94954544
137E2F1_21310950_ChIP-Seq_MCF-7_Human0.93995383
138RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93783574
139SUZ12_18555785_Chip-Seq_ESCs_Mouse0.93500392
140GATA3_24758297_ChIP-Seq_MCF-7_Human0.93444324
141NFYB_21822215_ChIP-Seq_K562_Human0.93293325
142GF1_26923725_Chip-Seq_HPCs_Mouse0.92197107
143CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92142569
144ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.91927511
145EP300_21415370_ChIP-Seq_HL-1_Mouse0.91692806
146CTCF_18555785_Chip-Seq_ESCs_Mouse0.91621148
147RUNX1_27457419_Chip-Seq_LIVER_Mouse0.91608725
148PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.91441528
149TCF4_22108803_ChIP-Seq_LS180_Human0.91081735
150HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.90932893
151LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90894224
152SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.90848793
153CMYC_18555785_Chip-Seq_ESCs_Mouse0.90846554
154PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.90480015
155CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.89643069
156ZFP57_27257070_Chip-Seq_ESCs_Mouse0.89230600
157NR3C1_21868756_ChIP-Seq_MCF10A_Human0.89183672
158NMYC_18555785_Chip-Seq_ESCs_Mouse0.89010572
159FOXA1_21572438_ChIP-Seq_LNCaP_Human0.88359289
160VDR_22108803_ChIP-Seq_LS180_Human0.88352924
161* GATA3_26560356_Chip-Seq_TH1_Human0.87999061
162SOX2_18555785_Chip-Seq_ESCs_Mouse0.86776180
163GATA3_21867929_ChIP-Seq_CD8_Mouse0.85787188
164IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.85426951
165CBP_20019798_ChIP-Seq_JUKART_Human0.85426951
166STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.84818767
167LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84775619

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation9.12040260
2MP0005410_abnormal_fertilization8.03534197
3* MP0001929_abnormal_gametogenesis5.06573589
4* MP0003698_abnormal_male_reproductive4.46572062
5* MP0002210_abnormal_sex_determination4.46306116
6MP0002009_preneoplasia4.22756289
7MP0000537_abnormal_urethra_morphology3.78450269
8MP0008057_abnormal_DNA_replication3.69058987
9* MP0001145_abnormal_male_reproductive3.52438562
10MP0005645_abnormal_hypothalamus_physiol3.50516618
11MP0004145_abnormal_muscle_electrophysio3.48889344
12* MP0000653_abnormal_sex_gland3.44409528
13MP0010094_abnormal_chromosome_stability3.22887184
14MP0008995_early_reproductive_senescence3.13188691
15MP0002653_abnormal_ependyma_morphology2.96472722
16MP0002234_abnormal_pharynx_morphology2.90831424
17* MP0002161_abnormal_fertility/fecundity2.82861186
18MP0003718_maternal_effect2.57097389
19MP0003646_muscle_fatigue2.51234336
20MP0002166_altered_tumor_susceptibility2.44930244
21MP0003786_premature_aging2.33103255
22MP0008058_abnormal_DNA_repair2.28473823
23MP0003111_abnormal_nucleus_morphology2.21858284
24MP0008789_abnormal_olfactory_epithelium2.13601067
25MP0003693_abnormal_embryo_hatching2.07029981
26MP0010234_abnormal_vibrissa_follicle2.06543540
27MP0002006_tumorigenesis2.03044242
28MP0003077_abnormal_cell_cycle2.02973857
29MP0003787_abnormal_imprinting1.95081424
30MP0002160_abnormal_reproductive_system1.91604423
31MP0008007_abnormal_cellular_replicative1.88595784
32MP0001119_abnormal_female_reproductive1.88479326
33MP0005499_abnormal_olfactory_system1.82511816
34MP0005394_taste/olfaction_phenotype1.82511816
35MP0003699_abnormal_female_reproductive1.73196252
36MP0002102_abnormal_ear_morphology1.68099372
37MP0006276_abnormal_autonomic_nervous1.65487472
38MP0008961_abnormal_basal_metabolism1.57559274
39MP0003121_genomic_imprinting1.54385079
40MP0000538_abnormal_urinary_bladder1.53601573
41MP0000631_abnormal_neuroendocrine_gland1.51771749
42MP0004957_abnormal_blastocyst_morpholog1.47694349
43MP0002735_abnormal_chemical_nociception1.47331803
44MP0005647_abnormal_sex_gland1.45332627
45MP0005389_reproductive_system_phenotype1.36128565
46MP0003123_paternal_imprinting1.29697216
47MP0002909_abnormal_adrenal_gland1.26940667
48MP0000569_abnormal_digit_pigmentation1.25895373
49MP0002822_catalepsy1.22186846
50MP0005623_abnormal_meninges_morphology1.21066477
51MP0005451_abnormal_body_composition1.20222107
52MP0001730_embryonic_growth_arrest1.19005080
53MP0003183_abnormal_peptide_metabolism1.18302165
54MP0005395_other_phenotype1.17362057
55MP0010678_abnormal_skin_adnexa1.16716767
56MP0004036_abnormal_muscle_relaxation1.14552499
57MP0005551_abnormal_eye_electrophysiolog1.10996912
58MP0001664_abnormal_digestion1.08686348
59MP0000383_abnormal_hair_follicle1.08481217
60MP0010307_abnormal_tumor_latency1.07460925
61MP0002272_abnormal_nervous_system1.07122051
62MP0005377_hearing/vestibular/ear_phenot1.02781853
63MP0003878_abnormal_ear_physiology1.02781853
64MP0008932_abnormal_embryonic_tissue1.00936541
65MP0000427_abnormal_hair_cycle0.97730860
66MP0000566_synostosis0.97189034
67MP0004808_abnormal_hematopoietic_stem0.96760831
68MP0002638_abnormal_pupillary_reflex0.94346446
69MP0004185_abnormal_adipocyte_glucose0.92479121
70MP0002108_abnormal_muscle_morphology0.90875423
71MP0002282_abnormal_trachea_morphology0.89580308
72MP0005360_urolithiasis0.88264660
73MP0002139_abnormal_hepatobiliary_system0.87929297
74MP0002084_abnormal_developmental_patter0.85527167
75MP0005380_embryogenesis_phenotype0.85018379
76MP0001672_abnormal_embryogenesis/_devel0.85018379
77MP0002085_abnormal_embryonic_tissue0.84915243
78MP0009780_abnormal_chondrocyte_physiolo0.83481651
79MP0005187_abnormal_penis_morphology0.82918759
80MP0000350_abnormal_cell_proliferation0.81708735
81MP0005367_renal/urinary_system_phenotyp0.79065918
82MP0000516_abnormal_urinary_system0.79065918
83MP0003890_abnormal_embryonic-extraembry0.78848879
84MP0000678_abnormal_parathyroid_gland0.78331564
85MP0001697_abnormal_embryo_size0.77619258
86MP0003315_abnormal_perineum_morphology0.77154465
87MP0002557_abnormal_social/conspecific_i0.74770423
88MP0001919_abnormal_reproductive_system0.74065880
89MP0001873_stomach_inflammation0.72170187
90MP0000627_abnormal_mammary_gland0.72026909
91MP0002736_abnormal_nociception_after0.71282836
92MP0001501_abnormal_sleep_pattern0.71059495
93MP0003937_abnormal_limbs/digits/tail_de0.70561529
94MP0000470_abnormal_stomach_morphology0.66617669
95MP0000313_abnormal_cell_death0.66615549
96MP0002734_abnormal_mechanical_nocicepti0.66338838
97MP0002138_abnormal_hepatobiliary_system0.65356973
98MP0002751_abnormal_autonomic_nervous0.65181731
99MP0001486_abnormal_startle_reflex0.64947325
100MP0002876_abnormal_thyroid_physiology0.64611739
101MP0004270_analgesia0.63072489
102MP0005167_abnormal_blood-brain_barrier0.62879247
103MP0004084_abnormal_cardiac_muscle0.62150568
104MP0003936_abnormal_reproductive_system0.61834860
105MP0009745_abnormal_behavioral_response0.60843314
106MP0003984_embryonic_growth_retardation0.60058710
107MP0004233_abnormal_muscle_weight0.59706092
108MP0000762_abnormal_tongue_morphology0.59006818
109MP0002837_dystrophic_cardiac_calcinosis0.58272023
110MP0004264_abnormal_extraembryonic_tissu0.57924118
111MP0005397_hematopoietic_system_phenotyp0.55960753
112MP0001545_abnormal_hematopoietic_system0.55960753
113MP0004134_abnormal_chest_morphology0.55830347
114MP0003861_abnormal_nervous_system0.55678563
115MP0002088_abnormal_embryonic_growth/wei0.54867884
116MP0001944_abnormal_pancreas_morphology0.54698042
117MP0001915_intracranial_hemorrhage0.54271316
118MP0001968_abnormal_touch/_nociception0.54067384
119MP0003283_abnormal_digestive_organ0.53554030
120MP0003879_abnormal_hair_cell0.53322403
121MP0009697_abnormal_copulation0.53275560
122MP0002019_abnormal_tumor_incidence0.52034199
123MP0003950_abnormal_plasma_membrane0.51560669
124MP0009278_abnormal_bone_marrow0.50171721
125MP0005076_abnormal_cell_differentiation0.49440907
126MP0002080_prenatal_lethality0.47882720
127MP0003115_abnormal_respiratory_system0.47320271
128MP0001727_abnormal_embryo_implantation0.47144453
129MP0000432_abnormal_head_morphology0.46397091
130MP0005670_abnormal_white_adipose0.45972105
131MP0000639_abnormal_adrenal_gland0.43199434
132MP0001984_abnormal_olfaction0.41967808
133MP0002249_abnormal_larynx_morphology0.40406289
134MP0002086_abnormal_extraembryonic_tissu0.39560066
135MP0002116_abnormal_craniofacial_bone0.39346903
136MP0006072_abnormal_retinal_apoptosis0.38102705
137MP0005310_abnormal_salivary_gland0.37978663
138MP0002233_abnormal_nose_morphology0.35811874
139MP0009672_abnormal_birth_weight0.34867986
140MP0001851_eye_inflammation0.34746628
141MP0005646_abnormal_pituitary_gland0.34697363
142MP0000579_abnormal_nail_morphology0.34645849
143MP0004197_abnormal_fetal_growth/weight/0.34143768
144MP0000358_abnormal_cell_content/0.33996159
145MP0000462_abnormal_digestive_system0.32222609
146MP0005408_hypopigmentation0.32096871
147MP0002114_abnormal_axial_skeleton0.32032545
148MP0005621_abnormal_cell_physiology0.31992469
149MP0005384_cellular_phenotype0.31962832
150MP0006292_abnormal_olfactory_placode0.29876827
151MP0000647_abnormal_sebaceous_gland0.29742872
152MP0003763_abnormal_thymus_physiology0.28975608
153MP0009046_muscle_twitch0.28162690
154MP0001661_extended_life_span0.27969129
155MP0003045_fibrosis0.27911548
156MP0002109_abnormal_limb_morphology0.27875068

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)9.21230846
2Absent/shortened dynein arms (HP:0200106)9.21230846
3Abnormal respiratory motile cilium physiology (HP:0012261)7.78484801
4Rhinitis (HP:0012384)6.60786275
5Abnormal respiratory motile cilium morphology (HP:0005938)6.32107297
6Abnormal respiratory epithelium morphology (HP:0012253)6.32107297
7Abnormal ciliary motility (HP:0012262)6.13845650
8Chronic bronchitis (HP:0004469)6.07426746
9Infertility (HP:0000789)5.85478753
10Testicular atrophy (HP:0000029)5.27001172
11Prostate neoplasm (HP:0100787)5.07402169
12Abnormality of the lower motor neuron (HP:0002366)4.85452851
13Nasal polyposis (HP:0100582)4.55872601
14Gonadotropin excess (HP:0000837)4.32813476
15Nephronophthisis (HP:0000090)4.30959210
16Calf muscle hypertrophy (HP:0008981)4.30065643
17Male infertility (HP:0003251)4.28914194
18Azoospermia (HP:0000027)4.18135200
19Abnormal spermatogenesis (HP:0008669)4.04116063
20Bronchiectasis (HP:0002110)3.95824195
21Lip pit (HP:0100267)3.78484066
22Muscle hypertrophy of the lower extremities (HP:0008968)3.72845114
23Abnormality of secondary sexual hair (HP:0009888)3.65665948
24Abnormality of the axillary hair (HP:0100134)3.65665948
25Abnormality of the nasal mucosa (HP:0000433)3.58423661
26Amyotrophic lateral sclerosis (HP:0007354)3.55685435
27Myokymia (HP:0002411)3.43530393
28Abnormality of the renal medulla (HP:0100957)3.36848001
29Gaze-evoked nystagmus (HP:0000640)3.34626447
30Fibular hypoplasia (HP:0003038)3.30942536
31Bronchitis (HP:0012387)3.26979088
32Aplasia/Hypoplasia of the tibia (HP:0005772)3.22367699
33Short tibia (HP:0005736)3.19804586
34Abnormality of the 1st metacarpal (HP:0010009)3.13814382
35Impulsivity (HP:0100710)3.13114213
36Upper motor neuron abnormality (HP:0002127)3.11576829
37Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)3.07563598
38Short 1st metacarpal (HP:0010034)3.07563598
39Papillary thyroid carcinoma (HP:0002895)3.05090950
4011 pairs of ribs (HP:0000878)3.02523589
41Tubulointerstitial nephritis (HP:0001970)2.97062314
42Abnormality of the phalanges of the hallux (HP:0010057)2.96658041
43Chromsome breakage (HP:0040012)2.94091843
44Dysdiadochokinesis (HP:0002075)2.88781179
45Abnormality of the anterior horn cell (HP:0006802)2.88659231
46Degeneration of anterior horn cells (HP:0002398)2.88659231
47Chromosomal breakage induced by crosslinking agents (HP:0003221)2.82239814
48Osteomalacia (HP:0002749)2.79685928
49Anterior segment dysgenesis (HP:0007700)2.79640275
50Molar tooth sign on MRI (HP:0002419)2.78943260
51Abnormality of midbrain morphology (HP:0002418)2.78943260
52Septate vagina (HP:0001153)2.76651740
53Supernumerary spleens (HP:0009799)2.70956893
54Abnormal tarsal ossification (HP:0008369)2.58742345
55Impaired proprioception (HP:0010831)2.58478771
56Recurrent otitis media (HP:0000403)2.54285055
57Bifid scrotum (HP:0000048)2.47306947
58Abnormality of the proximal phalanges of the hand (HP:0009834)2.43440653
59Oligodactyly (hands) (HP:0001180)2.42993233
60Ectopic kidney (HP:0000086)2.41516596
61Aplasia/Hypoplasia of the fovea (HP:0008060)2.39194381
62Hypoplasia of the fovea (HP:0007750)2.39194381
63Abnormality of the parathyroid morphology (HP:0011766)2.34842877
64Abdominal situs inversus (HP:0003363)2.34133252
65Abnormality of abdominal situs (HP:0011620)2.34133252
66Tubular atrophy (HP:0000092)2.32785934
67Selective tooth agenesis (HP:0001592)2.32085449
68Testicular neoplasm (HP:0010788)2.31673144
69Medial flaring of the eyebrow (HP:0010747)2.30804839
70Hypoplasia of the capital femoral epiphysis (HP:0003090)2.29630216
71Type II lissencephaly (HP:0007260)2.29269718
72Flat acetabular roof (HP:0003180)2.28666400
73Postaxial foot polydactyly (HP:0001830)2.28649419
74Aplasia/Hypoplasia of the fibula (HP:0006492)2.28434780
75Microglossia (HP:0000171)2.25378522
76Tubulointerstitial abnormality (HP:0001969)2.24473245
77Cone-rod dystrophy (HP:0000548)2.20963006
78Short phalanx of the thumb (HP:0009660)2.20848272
79Truncal obesity (HP:0001956)2.20508703
80Recurrent sinusitis (HP:0011108)2.19709598
81Dysmetric saccades (HP:0000641)2.19485501
82Impaired smooth pursuit (HP:0007772)2.13235003
83Volvulus (HP:0002580)2.13154614
84Microretrognathia (HP:0000308)2.13012218
85Stage 5 chronic kidney disease (HP:0003774)2.07891162
86Hyperpituitarism (HP:0010514)2.07058488
87Hypophosphatemic rickets (HP:0004912)2.06858081
88Aplastic anemia (HP:0001915)2.05548757
89Short thumb (HP:0009778)2.05409490
90Abnormality of the prostate (HP:0008775)2.04085832
91Chronic hepatic failure (HP:0100626)2.03769919
92Aplasia/Hypoplasia of the uvula (HP:0010293)2.03503937
93Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.03195084
94Sloping forehead (HP:0000340)2.02999851
95Abnormality of chromosome stability (HP:0003220)2.01034357
96Intrahepatic cholestasis (HP:0001406)2.00453147
97Heterotopia (HP:0002282)2.00253579
98Respiratory insufficiency due to defective ciliary clearance (HP:0200073)11.4551320
99Capillary hemangiomas (HP:0005306)1.98093563
100Renal dysplasia (HP:0000110)1.98025785
101Pancreatic cysts (HP:0001737)1.97697547
102Abnormality of the fovea (HP:0000493)1.97623803
103Nephroblastoma (Wilms tumor) (HP:0002667)1.96902087
104Renal cortical cysts (HP:0000803)1.94173418
105Attenuation of retinal blood vessels (HP:0007843)1.90849875
106Short ribs (HP:0000773)1.89498491
107Facial cleft (HP:0002006)1.88993495
108Breast carcinoma (HP:0003002)1.86572025
109Amelogenesis imperfecta (HP:0000705)1.86312131
110Median cleft lip (HP:0000161)1.85231162
111Abnormality of the labia minora (HP:0012880)1.85058540
112Pendular nystagmus (HP:0012043)1.83463426
113Urethral obstruction (HP:0000796)1.82944704
114Aplasia/Hypoplasia of the sternum (HP:0006714)1.82731997
115Oculomotor apraxia (HP:0000657)1.82400971
116Meckel diverticulum (HP:0002245)1.82120451
117Bony spicule pigmentary retinopathy (HP:0007737)1.82061530
118Depressed nasal tip (HP:0000437)1.81970466
119Embryonal renal neoplasm (HP:0011794)1.80871703
120Abnormality of male internal genitalia (HP:0000022)1.77013178
121Absent epiphyses (HP:0010577)1.76662218
122Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.76662218
123Congenital hepatic fibrosis (HP:0002612)1.76413841
124Abnormality of the preputium (HP:0100587)1.76282789
125Spinal cord compression (HP:0002176)1.74263472
126Genetic anticipation (HP:0003743)1.74154937
127Sandal gap (HP:0001852)1.73292406
128Lower limb hyperreflexia (HP:0002395)1.72597850
129Primary amenorrhea (HP:0000786)1.72373813
130Hypokinesia (HP:0002375)1.71499650
131Abnormality of the calf musculature (HP:0001430)1.71076883
132Abnormality of the ileum (HP:0001549)1.71057477
133Fibular aplasia (HP:0002990)1.70761021
134Short thorax (HP:0010306)1.70725277
135Absent frontal sinuses (HP:0002688)1.69778517
136Abnormal foot bone ossification (HP:0010675)1.69648328
137Large eyes (HP:0001090)1.69474248
138Atrophy/Degeneration involving motor neurons (HP:0007373)1.69373511
139Non-midline cleft lip (HP:0100335)1.68860671
140Abnormal biliary tract physiology (HP:0012439)1.68829096
141Bile duct proliferation (HP:0001408)1.68829096
142Postaxial hand polydactyly (HP:0001162)1.67983356
143Patellar aplasia (HP:0006443)1.67745465
144Male pseudohermaphroditism (HP:0000037)1.66611995
145Premature ovarian failure (HP:0008209)1.66503906
146Cystic liver disease (HP:0006706)1.66072138
147Abnormality of the renal cortex (HP:0011035)1.66048270
148Septo-optic dysplasia (HP:0100842)1.65832461
149Aplasia/Hypoplasia of the tongue (HP:0010295)1.65509423
150Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.65392371
151Abnormality of the carotid arteries (HP:0005344)1.64775258
152Duodenal stenosis (HP:0100867)1.64099030
153Small intestinal stenosis (HP:0012848)1.64099030
154Pancreatic fibrosis (HP:0100732)1.63992538
155Missing ribs (HP:0000921)1.63557806
156Facial hemangioma (HP:0000329)1.63387034
157Abnormality of the fibula (HP:0002991)1.62690645
158Prominent nose (HP:0000448)1.61223833
159Abnormality of carpal bone ossification (HP:0006257)1.61164396
160Enlarged penis (HP:0000040)1.60392048
161Dislocated radial head (HP:0003083)1.59317787
162Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.59125753
163Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.59105538
164Methylmalonic acidemia (HP:0002912)1.59049710
165Poor coordination (HP:0002370)1.57237736
166Abnormal auditory evoked potentials (HP:0006958)1.57026502
167Abnormality of the epiphyses of the hand (HP:0005924)1.56575476
168Fair hair (HP:0002286)1.56496451
169Aplasia/Hypoplasia of the patella (HP:0006498)1.56198451
170Aplasia/Hypoplasia of the earlobes (HP:0009906)1.56195996
171Abnormality of dentin (HP:0010299)1.55740890
172Thyroid carcinoma (HP:0002890)1.55718013
173Spontaneous abortion (HP:0005268)1.55061897
174Abnormality of the dental root (HP:0006486)1.52017124
175Taurodontia (HP:0000679)1.52017124
176Abnormality of permanent molar morphology (HP:0011071)1.52017124
177Tubulointerstitial fibrosis (HP:0005576)1.51794751
178Acute myeloid leukemia (HP:0004808)1.48410288

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK47.54736034
2PDK37.54736034
3CAMK1D6.32935501
4TNK25.28190498
5PDK24.68516162
6CDC73.37370368
7ARAF3.28795399
8PRKD33.00887176
9NEK22.75599945
10FER2.58977670
11CDK122.55247469
12PRKCI2.52971744
13TTK2.45218743
14PLK42.43455229
15LATS12.11199660
16STK38L2.10336882
17STK31.97675852
18ICK1.91121308
19TESK11.84263937
20PTK2B1.80702653
21NEK61.74856477
22PIM21.72776780
23PNCK1.70070235
24MAP3K61.66693157
25CHEK21.57615075
26MAP3K131.57376958
27WNK41.51292170
28EEF2K1.50731467
29BRAF1.44646258
30LATS21.44489222
31TYRO31.38003686
32AKT31.33966055
33STK391.31543822
34MAP3K41.27093675
35MET1.23818372
36STK381.22439845
37PLK11.19400040
38ACVR1B1.16751888
39MUSK1.14717670
40CHEK11.14568790
41ATR1.13853319
42EIF2AK31.12917136
43MST41.12642495
44TRIB31.06755171
45FRK1.05731421
46TAOK31.05310905
47NUAK11.01731330
48TAOK10.98980315
49WEE10.97741042
50ERBB40.97619449
51CDK90.91709147
52WNK10.91530144
53ATM0.90518439
54CAMK10.88355138
55ZAK0.84805343
56CDK80.83100402
57TRIM280.81952399
58BMPR1B0.81417405
59CCNB10.72000336
60PINK10.70720188
61STK100.70173897
62PRKCZ0.67810026
63MAP2K70.66888578
64TLK10.63841775
65MELK0.62582254
66MAPKAPK30.61527490
67CHUK0.60838926
68CDK70.60570402
69MAP3K90.60205661
70MAP4K20.60133709
71MTOR0.59694746
72TIE10.56988245
73PRKAA10.55118063
74NTRK20.54317182
75WNK30.53393885
76TNIK0.52230898
77CSNK1G10.52106887
78AURKB0.51745101
79PASK0.51391763
80GRK10.50574484
81PAK60.47735077
82KSR20.47728162
83MATK0.46076334
84PIK3CA0.45351160
85PKN20.45022299
86CDK10.44245886
87CDK20.42350776
88BRD40.42018663
89CAMK1G0.40882146
90MINK10.40428599
91MAPK150.39545895
92CDK30.38878389
93CDK40.38292414
94PDK10.35291352
95DYRK30.33994955
96MAPK130.33330198
97BUB10.33330177
98CAMK40.33158954
99NME10.32733943
100CSNK1G30.31616352
101CSNK1D0.31518774
102PRKCE0.30745046
103AURKA0.30320093
104PLK20.29204760
105CAMK2A0.29065776
106PTK20.29053424
107TGFBR10.28753227
108IRAK20.28355811
109MAPKAPK50.28190837
110RAF10.27828030
111PRKD20.27150708
112SRPK10.27126872
113PRKACA0.26982350
114BRSK20.26092886
115ADRBK20.26079154
116INSRR0.25123099
117PRKG10.24424856
118PIM10.24329467
119GSK3B0.23971526
120CSNK1A1L0.23434562
121PRKD10.22238433
122BCR0.21696881
123RPS6KA40.21086615
124PLK30.21074601
125MARK20.18996263
126MAPK100.18700095
127MOS0.18622939
128MAP3K80.18600768
129RPS6KB10.18296718
130PRKDC0.17689461
131MAPK140.17572799
132DMPK0.17091380
133BRSK10.16998172
134STK110.16656935
135AKT10.16378247
136PRKAA20.16086248
137STK40.14809830
138CSNK1E0.14691442
139PAK10.14286840
140STK240.13255020
141EIF2AK10.13004351
142MAPK10.12936097
143MAP2K40.12126891
144MAP3K50.11941221
145RET0.10704877
146KSR10.10367764
147ABL10.10070652

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal transcription factors_Homo sapiens_hsa030224.76794997
2Fanconi anemia pathway_Homo sapiens_hsa034604.13573363
3Vitamin B6 metabolism_Homo sapiens_hsa007504.08372374
4Dorso-ventral axis formation_Homo sapiens_hsa043203.86974912
5Cell cycle_Homo sapiens_hsa041103.08956330
6Homologous recombination_Homo sapiens_hsa034403.01547739
7RNA transport_Homo sapiens_hsa030132.78235864
8Oocyte meiosis_Homo sapiens_hsa041142.63307779
9Pyruvate metabolism_Homo sapiens_hsa006202.55783883
10RNA degradation_Homo sapiens_hsa030182.47742152
11mRNA surveillance pathway_Homo sapiens_hsa030152.32662034
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.30828043
13alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.22498113
14Linoleic acid metabolism_Homo sapiens_hsa005912.12203852
15Steroid biosynthesis_Homo sapiens_hsa001002.07031934
16Selenocompound metabolism_Homo sapiens_hsa004502.03481723
17Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.91278083
18Nicotine addiction_Homo sapiens_hsa050331.90117570
19Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.88657525
20Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.84816155
21Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.73892432
22Non-homologous end-joining_Homo sapiens_hsa034501.73891728
23Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.73806203
24Phototransduction_Homo sapiens_hsa047441.72409436
25Glucagon signaling pathway_Homo sapiens_hsa049221.71009276
26Cysteine and methionine metabolism_Homo sapiens_hsa002701.68247442
27Ovarian steroidogenesis_Homo sapiens_hsa049131.65589149
28p53 signaling pathway_Homo sapiens_hsa041151.60006843
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.54987150
30Propanoate metabolism_Homo sapiens_hsa006401.51822376
31Pentose phosphate pathway_Homo sapiens_hsa000301.51073862
32Renin-angiotensin system_Homo sapiens_hsa046141.47274276
33Caffeine metabolism_Homo sapiens_hsa002321.40294217
34Ether lipid metabolism_Homo sapiens_hsa005651.32510790
35Nucleotide excision repair_Homo sapiens_hsa034201.31833463
36Base excision repair_Homo sapiens_hsa034101.31529133
37Mismatch repair_Homo sapiens_hsa034301.29010359
38Fatty acid biosynthesis_Homo sapiens_hsa000611.28420961
39DNA replication_Homo sapiens_hsa030301.25757981
40Olfactory transduction_Homo sapiens_hsa047401.21515926
41Fatty acid metabolism_Homo sapiens_hsa012121.18531008
42Glycerolipid metabolism_Homo sapiens_hsa005611.18124927
43Gap junction_Homo sapiens_hsa045401.08652305
44Glycerophospholipid metabolism_Homo sapiens_hsa005641.06535265
45Serotonergic synapse_Homo sapiens_hsa047261.06321745
46Morphine addiction_Homo sapiens_hsa050321.03948527
47Taste transduction_Homo sapiens_hsa047421.00345971
48Aldosterone synthesis and secretion_Homo sapiens_hsa049250.99439085
49Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.98072001
50Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.97165177
51GABAergic synapse_Homo sapiens_hsa047270.96168943
52Purine metabolism_Homo sapiens_hsa002300.96075913
53Lysine degradation_Homo sapiens_hsa003100.92981673
54Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.92878591
55Vitamin digestion and absorption_Homo sapiens_hsa049770.91795034
56Huntingtons disease_Homo sapiens_hsa050160.90703374
57Long-term depression_Homo sapiens_hsa047300.86790022
58Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.86716191
59Circadian rhythm_Homo sapiens_hsa047100.86396813
60Spliceosome_Homo sapiens_hsa030400.86172846
61TGF-beta signaling pathway_Homo sapiens_hsa043500.85256133
62Cholinergic synapse_Homo sapiens_hsa047250.83424177
63Synaptic vesicle cycle_Homo sapiens_hsa047210.82366720
64Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.81904703
65Insulin secretion_Homo sapiens_hsa049110.80463559
66Circadian entrainment_Homo sapiens_hsa047130.76751938
67Thyroid hormone synthesis_Homo sapiens_hsa049180.75801116
68Herpes simplex infection_Homo sapiens_hsa051680.72925831
69VEGF signaling pathway_Homo sapiens_hsa043700.72454580
70Arginine and proline metabolism_Homo sapiens_hsa003300.71094222
71HTLV-I infection_Homo sapiens_hsa051660.71035089
72Dopaminergic synapse_Homo sapiens_hsa047280.70030890
73Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.69244631
74Pancreatic cancer_Homo sapiens_hsa052120.67322766
75Pyrimidine metabolism_Homo sapiens_hsa002400.65423382
76Antigen processing and presentation_Homo sapiens_hsa046120.64752557
77Salivary secretion_Homo sapiens_hsa049700.64627397
78Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.63843880
79RNA polymerase_Homo sapiens_hsa030200.62926056
80Glutamatergic synapse_Homo sapiens_hsa047240.61096746
81Nitrogen metabolism_Homo sapiens_hsa009100.61017149
82Bile secretion_Homo sapiens_hsa049760.60851529
83Estrogen signaling pathway_Homo sapiens_hsa049150.59810581
84Inositol phosphate metabolism_Homo sapiens_hsa005620.59769625
85Phosphatidylinositol signaling system_Homo sapiens_hsa040700.58346695
86Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56796765
87Amphetamine addiction_Homo sapiens_hsa050310.56617988
88Viral carcinogenesis_Homo sapiens_hsa052030.56127568
89Epstein-Barr virus infection_Homo sapiens_hsa051690.55004771
90MicroRNAs in cancer_Homo sapiens_hsa052060.54789658
91Calcium signaling pathway_Homo sapiens_hsa040200.53808126
92Hedgehog signaling pathway_Homo sapiens_hsa043400.53153519
93Small cell lung cancer_Homo sapiens_hsa052220.51781770
94Wnt signaling pathway_Homo sapiens_hsa043100.50510698
95Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.49938730
96Maturity onset diabetes of the young_Homo sapiens_hsa049500.49651883
97Butanoate metabolism_Homo sapiens_hsa006500.48387915
98Longevity regulating pathway - mammal_Homo sapiens_hsa042110.48196854
99Carbohydrate digestion and absorption_Homo sapiens_hsa049730.47510132
100Renin secretion_Homo sapiens_hsa049240.46771403
101Hippo signaling pathway_Homo sapiens_hsa043900.44376624
102mTOR signaling pathway_Homo sapiens_hsa041500.44102239
103Influenza A_Homo sapiens_hsa051640.43800673
104Fatty acid elongation_Homo sapiens_hsa000620.42466129
105Choline metabolism in cancer_Homo sapiens_hsa052310.40380314
106Gastric acid secretion_Homo sapiens_hsa049710.39791008
107Histidine metabolism_Homo sapiens_hsa003400.39659483
108Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.39519629
109cGMP-PKG signaling pathway_Homo sapiens_hsa040220.38460393
110Peroxisome_Homo sapiens_hsa041460.38350959
111Primary bile acid biosynthesis_Homo sapiens_hsa001200.38154810
112Central carbon metabolism in cancer_Homo sapiens_hsa052300.37843922
113Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.37476793
114Long-term potentiation_Homo sapiens_hsa047200.37220826
115Adherens junction_Homo sapiens_hsa045200.36068750
116Colorectal cancer_Homo sapiens_hsa052100.35601948
117Basal cell carcinoma_Homo sapiens_hsa052170.35361447
118Pancreatic secretion_Homo sapiens_hsa049720.35095170
119Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.34261840
120Prolactin signaling pathway_Homo sapiens_hsa049170.33940278
121AMPK signaling pathway_Homo sapiens_hsa041520.31852829
122Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.31755188
123Biosynthesis of amino acids_Homo sapiens_hsa012300.31265409
124Notch signaling pathway_Homo sapiens_hsa043300.29797647
125Arachidonic acid metabolism_Homo sapiens_hsa005900.29796356
126Sphingolipid metabolism_Homo sapiens_hsa006000.28891506
127PPAR signaling pathway_Homo sapiens_hsa033200.25612864
128cAMP signaling pathway_Homo sapiens_hsa040240.24862886
129Glycosaminoglycan degradation_Homo sapiens_hsa005310.24769921
130Prostate cancer_Homo sapiens_hsa052150.23341085
131ABC transporters_Homo sapiens_hsa020100.22090079
132FoxO signaling pathway_Homo sapiens_hsa040680.21552437
133Toxoplasmosis_Homo sapiens_hsa051450.19955115
134Mineral absorption_Homo sapiens_hsa049780.19358899
135Tight junction_Homo sapiens_hsa045300.18096407
136Transcriptional misregulation in cancer_Homo sapiens_hsa052020.17494882
137Ras signaling pathway_Homo sapiens_hsa040140.17236923
138Vascular smooth muscle contraction_Homo sapiens_hsa042700.17204362
139Systemic lupus erythematosus_Homo sapiens_hsa053220.14415580
140Phospholipase D signaling pathway_Homo sapiens_hsa040720.14117304
141Thyroid cancer_Homo sapiens_hsa052160.13460642
142Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.13322774
143Endocytosis_Homo sapiens_hsa041440.13217708
144Endometrial cancer_Homo sapiens_hsa052130.12583593
145MAPK signaling pathway_Homo sapiens_hsa040100.11926045
146N-Glycan biosynthesis_Homo sapiens_hsa005100.10993404

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