TDRD10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synapsis (GO:0007129)8.72383570
2DNA methylation involved in gamete generation (GO:0043046)8.40484601
3male meiosis I (GO:0007141)7.73591442
4fusion of sperm to egg plasma membrane (GO:0007342)7.50163429
5male meiosis (GO:0007140)7.40878296
6acrosome reaction (GO:0007340)7.20784305
7chromosome organization involved in meiosis (GO:0070192)7.11173689
8synaptonemal complex assembly (GO:0007130)6.74410333
9sperm motility (GO:0030317)6.54879165
10gonadal mesoderm development (GO:0007506)6.38599143
11plasma membrane fusion (GO:0045026)6.36840763
12positive regulation of meiosis (GO:0045836)6.21716921
13spermatid development (GO:0007286)6.18678826
14meiosis I (GO:0007127)6.14899434
15meiotic nuclear division (GO:0007126)6.10428483
16synaptonemal complex organization (GO:0070193)6.06929770
17positive regulation of meiotic cell cycle (GO:0051446)5.79973680
18binding of sperm to zona pellucida (GO:0007339)5.39102731
19chromosome condensation (GO:0030261)5.20474202
20DNA packaging (GO:0006323)5.14899327
21endothelium development (GO:0003158)5.02570668
22sperm-egg recognition (GO:0035036)5.02227857
23sperm capacitation (GO:0048240)4.92748285
24meiotic cell cycle process (GO:1903046)4.92028389
25spermatogenesis (GO:0007283)4.83207264
26male gamete generation (GO:0048232)4.83023777
27germ cell development (GO:0007281)4.78993873
28meiotic chromosome segregation (GO:0045132)4.60226648
29gamete generation (GO:0007276)4.55629711
30multicellular organism reproduction (GO:0032504)4.51199615
31microtubule depolymerization (GO:0007019)4.40817614
32female gamete generation (GO:0007292)4.37675505
33histone H3-K9 demethylation (GO:0033169)4.33934545
34lymphangiogenesis (GO:0001946)4.27300912
35protein targeting to Golgi (GO:0000042)4.25089591
36gene silencing by RNA (GO:0031047)4.24795500
37regulation of meiosis (GO:0040020)4.19964625
38negative regulation of meiosis (GO:0045835)4.19733021
39reproduction (GO:0000003)4.19295693
40regulation of meiotic cell cycle (GO:0051445)4.16747182
41oogenesis (GO:0048477)4.16504655
42negative regulation of inclusion body assembly (GO:0090084)4.12142247
43cellular process involved in reproduction in multicellular organism (GO:0022412)4.09758690
44cell-cell recognition (GO:0009988)4.07980237
45DNA synthesis involved in DNA repair (GO:0000731)4.04981368
46single strand break repair (GO:0000012)4.00200195
47fertilization (GO:0009566)3.99825611
48establishment of protein localization to Golgi (GO:0072600)3.99185987
49sexual reproduction (GO:0019953)3.98607116
50retrograde transport, vesicle recycling within Golgi (GO:0000301)3.92785938
51spermatid nucleus differentiation (GO:0007289)3.89553020
52calcium ion-dependent exocytosis (GO:0017156)3.86968068
53microtubule polymerization or depolymerization (GO:0031109)3.77652068
54meiotic cell cycle (GO:0051321)3.74268023
55sister chromatid cohesion (GO:0007062)3.73319382
56phosphatidylethanolamine biosynthetic process (GO:0006646)3.69571308
57oocyte development (GO:0048599)3.68282638
58multicellular organismal reproductive process (GO:0048609)3.65545180
59seminiferous tubule development (GO:0072520)3.53382724
60protein polyglutamylation (GO:0018095)3.51613016
61centriole replication (GO:0007099)3.49919391
62phosphatidylethanolamine metabolic process (GO:0046337)3.49236762
63negative regulation of Rho protein signal transduction (GO:0035024)3.44542106
64sex differentiation (GO:0007548)3.40046768
65rRNA methylation (GO:0031167)3.36878160
66microtubule severing (GO:0051013)3.35441892
67resolution of meiotic recombination intermediates (GO:0000712)3.33473383
68negative regulation of gene silencing (GO:0060969)3.29927720
69gene silencing (GO:0016458)3.18455391
70centriole assembly (GO:0098534)3.18195917
71single fertilization (GO:0007338)3.17328399
72positive regulation of endothelial cell differentiation (GO:0045603)3.16685459
73regulation of histone H3-K9 methylation (GO:0051570)3.15681122
74protein localization to Golgi apparatus (GO:0034067)3.13504380
75motile cilium assembly (GO:0044458)2.99153620
76labyrinthine layer development (GO:0060711)2.85326044
77cerebral cortex neuron differentiation (GO:0021895)2.84911076
78regulation of endothelial cell differentiation (GO:0045601)2.84755404
79regulation of centriole replication (GO:0046599)2.82850897
80negative regulation of meiotic cell cycle (GO:0051447)2.82626534
81nucleus organization (GO:0006997)2.76551863
82regulation of inclusion body assembly (GO:0090083)2.75245940
83histone H3-K36 demethylation (GO:0070544)2.73740967
84DNA methylation (GO:0006306)2.71592419
85DNA alkylation (GO:0006305)2.71592419
86embryonic foregut morphogenesis (GO:0048617)2.70122191
87blood vessel maturation (GO:0001955)2.68858189
88oocyte maturation (GO:0001556)2.67788953
89response to pheromone (GO:0019236)2.67217159
90organic cation transport (GO:0015695)2.66453051
91coronary vasculature morphogenesis (GO:0060977)2.65230629
92lymph vessel development (GO:0001945)2.58171999
93reciprocal DNA recombination (GO:0035825)2.54313827
94reciprocal meiotic recombination (GO:0007131)2.54313827
95rRNA modification (GO:0000154)2.54077156
96regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.51408011
97regulation of Rab GTPase activity (GO:0032313)2.51245104
98positive regulation of Rab GTPase activity (GO:0032851)2.51245104
99piRNA metabolic process (GO:0034587)12.1646460
100regulation of meiosis I (GO:0060631)10.1254765

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat6.09895399
2EZH2_22144423_ChIP-Seq_EOC_Human2.63988697
3MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.58709342
4IGF1R_20145208_ChIP-Seq_DFB_Human2.47256297
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.24152225
6GATA2_21666600_ChIP-Seq_HMVEC_Human2.17393503
7PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.11140278
8VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.10881472
9BP1_19119308_ChIP-ChIP_Hs578T_Human2.10035521
10MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.07592054
11YY1_22570637_ChIP-Seq_MALME-3M_Human1.83550734
12ERA_21632823_ChIP-Seq_H3396_Human1.76731529
13SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.75888709
14* CTCF_27219007_Chip-Seq_Bcells_Human1.75364331
15FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.71939910
16ELF1_20517297_ChIP-Seq_JURKAT_Human1.71885733
17KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.71021713
18KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.71021713
19KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.71021713
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.70944042
21RAC3_21632823_ChIP-Seq_H3396_Human1.66590355
22BCL6_27268052_Chip-Seq_Bcells_Human1.58091260
23* P68_20966046_ChIP-Seq_HELA_Human1.57863025
24* SMC4_20622854_ChIP-Seq_HELA_Human1.55851625
25PHF8_20622854_ChIP-Seq_HELA_Human1.53755587
26UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.53648405
27MYC_19829295_ChIP-Seq_ESCs_Human1.47862813
28WDR5_24793694_ChIP-Seq_LNCAP_Human1.46484025
29BCOR_27268052_Chip-Seq_Bcells_Human1.42161859
30OCT4_20526341_ChIP-Seq_ESCs_Human1.41770095
31VDR_22108803_ChIP-Seq_LS180_Human1.40416392
32SMAD4_21741376_ChIP-Seq_EPCs_Human1.40406088
33RUNX1_26923725_Chip-Seq_HPCs_Mouse1.39437465
34SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.34992623
35OCT4_19829295_ChIP-Seq_ESCs_Human1.33593927
36ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.31681540
37TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30936315
38POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.30936315
39NANOG_20526341_ChIP-Seq_ESCs_Human1.30515341
40GATA3_21878914_ChIP-Seq_MCF-7_Human1.28959827
41TET1_21490601_ChIP-Seq_MESCs_Mouse1.28682749
42* E2F1_20622854_ChIP-Seq_HELA_Human1.28568315
43CTBP1_25329375_ChIP-Seq_LNCAP_Human1.28242259
44* EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.27875247
45RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.27296742
46TP63_22573176_ChIP-Seq_HFKS_Human1.26516724
47KLF4_19829295_ChIP-Seq_ESCs_Human1.25037948
48IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.23028653
49CBP_20019798_ChIP-Seq_JUKART_Human1.23028653
50CTCF_20526341_ChIP-Seq_ESCs_Human1.22537721
51* ETV1_20927104_ChIP-Seq_GIST48_Human1.21743247
52ER_23166858_ChIP-Seq_MCF-7_Human1.21726860
53AUTS2_25519132_ChIP-Seq_293T-REX_Human1.21181692
54* CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.21110529
55CBX2_22325352_ChIP-Seq_293T-Rex_Human1.20246960
56SOX2_21211035_ChIP-Seq_LN229_Human1.19566122
57ELK4_26923725_Chip-Seq_MESODERM_Mouse1.19482022
58RUNX2_22187159_ChIP-Seq_PCA_Human1.19136902
59AR_25329375_ChIP-Seq_VCAP_Human1.19058077
60FOXH1_21741376_ChIP-Seq_EPCs_Human1.18734093
61ZNF274_21170338_ChIP-Seq_K562_Hela1.17311539
62TAF2_19829295_ChIP-Seq_ESCs_Human1.16896128
63P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.16179572
64EP300_21415370_ChIP-Seq_HL-1_Mouse1.16041182
65* HNFA_21074721_ChIP-Seq_CACO-2_Human1.15130268
66ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.14528194
67HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.13854862
68GATA1_19941827_ChIP-Seq_MEL86_Mouse1.13714057
69EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.13508788
70STAT3_23295773_ChIP-Seq_U87_Human1.12048199
71* PHF8_20622853_ChIP-Seq_HELA_Human1.11709293
72SOX11_22085726_ChIP-Seq_ESNs_Mouse1.11447862
73PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.08806675
74PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.08640729
75NFYB_21822215_ChIP-Seq_K562_Human1.08565166
76* RBPJ_21746931_ChIP-Seq_IB4_Human1.08344984
77PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.07644987
78EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.07628413
79CEBPB_22108803_ChIP-Seq_LS180_Human1.07304281
80DROSHA_22980978_ChIP-Seq_HELA_Human1.07013960
81NFIB_24661679_ChIP-Seq_LUNG_Mouse1.07011644
82ERG_20517297_ChIP-Seq_VCAP_Human1.06541723
83SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.05459500
84BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human1.05459108
85GF1_26923725_Chip-Seq_HPCs_Mouse1.05239324
86P300_27268052_Chip-Seq_Bcells_Human1.05156420
87CTBP2_25329375_ChIP-Seq_LNCAP_Human1.05010301
88FOXA1_21572438_ChIP-Seq_LNCaP_Human1.03574090
89CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.02881681
90TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01428061
91CBP_21632823_ChIP-Seq_H3396_Human1.01344577
92SMAD3_21741376_ChIP-Seq_ESCs_Human1.00034114
93KLF5_20875108_ChIP-Seq_MESCs_Mouse0.99088108
94PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.98785902
95FOXH1_21741376_ChIP-Seq_ESCs_Human0.98024696
96TBL1_22424771_ChIP-Seq_293T_Human0.96878642
97RAD21_21589869_ChIP-Seq_MESCs_Mouse0.96816701
98SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.96328079
99LXR_22292898_ChIP-Seq_THP-1_Human0.96231326
100SOX2_22085726_ChIP-Seq_NPCs_Mouse0.95563540

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010368_abnormal_lymphatic_system7.36004823
2MP0005410_abnormal_fertilization6.38918928
3MP0008877_abnormal_DNA_methylation4.83079410
4MP0005670_abnormal_white_adipose4.64460856
5MP0001879_abnormal_lymphatic_vessel3.79195571
6MP0001929_abnormal_gametogenesis3.72147394
7MP0003698_abnormal_male_reproductive3.43726664
8MP0002210_abnormal_sex_determination3.12287671
9MP0005167_abnormal_blood-brain_barrier3.05246337
10MP0003646_muscle_fatigue2.64326129
11MP0001145_abnormal_male_reproductive2.32862802
12MP0000653_abnormal_sex_gland2.27909779
13MP0005409_darkened_coat_color2.26025855
14MP0002138_abnormal_hepatobiliary_system2.00892992
15MP0002161_abnormal_fertility/fecundity2.00716415
16MP0000751_myopathy1.98628440
17MP0003718_maternal_effect1.90581920
18MP0004036_abnormal_muscle_relaxation1.87045286
19MP0006138_congestive_heart_failure1.79016508
20MP0003878_abnormal_ear_physiology1.78983344
21MP0005377_hearing/vestibular/ear_phenot1.78983344
22MP0005666_abnormal_adipose_tissue1.68326396
23MP0004215_abnormal_myocardial_fiber1.65283867
24MP0004084_abnormal_cardiac_muscle1.60370815
25MP0000678_abnormal_parathyroid_gland1.54946199
26MP0005375_adipose_tissue_phenotype1.54497821
27MP0006054_spinal_hemorrhage1.53306923
28MP0004782_abnormal_surfactant_physiolog1.51829600
29MP0000003_abnormal_adipose_tissue1.50765053
30MP0003950_abnormal_plasma_membrane1.49677130
31MP0003195_calcinosis1.45924309
32MP0002160_abnormal_reproductive_system1.45649228
33MP0000767_abnormal_smooth_muscle1.44645999
34MP0003828_pulmonary_edema1.42335885
35MP0008004_abnormal_stomach_pH1.38131716
36MP0003879_abnormal_hair_cell1.37739282
37MP0000013_abnormal_adipose_tissue1.37440566
38MP0005330_cardiomyopathy1.34403533
39MP0005647_abnormal_sex_gland1.32246996
40MP0005174_abnormal_tail_pigmentation1.31896900
41MP0004233_abnormal_muscle_weight1.28706514
42MP0002127_abnormal_cardiovascular_syste1.28536235
43MP0008260_abnormal_autophagy1.27545117
44MP0005395_other_phenotype1.22245517
45MP0004272_abnormal_basement_membrane1.13238260
46MP0001661_extended_life_span1.12515298
47MP0000749_muscle_degeneration1.10272315
48MP0003699_abnormal_female_reproductive1.05311450
49MP0005595_abnormal_vascular_smooth1.00888812
50MP0009115_abnormal_fat_cell0.99348063
51MP0001544_abnormal_cardiovascular_syste0.94584678
52MP0005385_cardiovascular_system_phenoty0.94584678
53MP0004085_abnormal_heartbeat0.94386134
54MP0000249_abnormal_blood_vessel0.93546956
55MP0001119_abnormal_female_reproductive0.89756390
56MP0002971_abnormal_brown_adipose0.88153882
57MP0002837_dystrophic_cardiac_calcinosis0.87139253
58MP0004484_altered_response_of0.87023170
59MP0002295_abnormal_pulmonary_circulatio0.84657400
60MP0005360_urolithiasis0.82003002
61MP0005365_abnormal_bile_salt0.79709804
62MP0003136_yellow_coat_color0.78036221
63MP0001614_abnormal_blood_vessel0.77776122
64MP0005058_abnormal_lysosome_morphology0.77094973
65MP0010630_abnormal_cardiac_muscle0.76165918
66MP0005620_abnormal_muscle_contractility0.74090097
67MP0003959_abnormal_lean_body0.73557342
68MP0003693_abnormal_embryo_hatching0.71785351
69MP0002269_muscular_atrophy0.71029679
70MP0001958_emphysema0.70332117
71MP0008775_abnormal_heart_ventricle0.69022970
72MP0005171_absent_coat_pigmentation0.68825654
73MP0003279_aneurysm0.68488671
74MP0002925_abnormal_cardiovascular_devel0.68181584
75MP0003868_abnormal_feces_composition0.66741169
76MP0002168_other_aberrant_phenotype0.66529898
77MP0002972_abnormal_cardiac_muscle0.66143067
78MP0002128_abnormal_blood_circulation0.65696947
79MP0000230_abnormal_systemic_arterial0.62114548
80MP0003183_abnormal_peptide_metabolism0.60324015
81MP0002332_abnormal_exercise_endurance0.59528037
82MP0001188_hyperpigmentation0.59398845
83MP0004087_abnormal_muscle_fiber0.59312287
84MP0000266_abnormal_heart_morphology0.58698728
85MP0004130_abnormal_muscle_cell0.58538710
86MP0002108_abnormal_muscle_morphology0.57601715
87MP0010329_abnormal_lipoprotein_level0.57004653
88MP0002106_abnormal_muscle_physiology0.54025490
89MP0000465_gastrointestinal_hemorrhage0.53237906
90MP0005535_abnormal_body_temperature0.53170237
91MP0003936_abnormal_reproductive_system0.52260365
92MP0001784_abnormal_fluid_regulation0.52152310
93MP0005165_increased_susceptibility_to0.50255338
94MP0005275_abnormal_skin_tensile0.50024294
95MP0005388_respiratory_system_phenotype0.49232141
96MP0002133_abnormal_respiratory_system0.49232141
97MP0001486_abnormal_startle_reflex0.49182333
98MP0001986_abnormal_taste_sensitivity0.48053147
99MP0002118_abnormal_lipid_homeostasis0.48024105
100MP0005389_reproductive_system_phenotype0.47729538

Predicted human phenotypes

RankGene SetZ-score
1Tubulointerstitial nephritis (HP:0001970)4.91481923
2Asymmetric septal hypertrophy (HP:0001670)4.64021866
3Gonadotropin excess (HP:0000837)4.44895960
4Osteomalacia (HP:0002749)4.24850414
5Male infertility (HP:0003251)4.23201927
6Horizontal nystagmus (HP:0000666)3.79540406
7Hypophosphatemic rickets (HP:0004912)3.51661642
8Portal hypertension (HP:0001409)3.51485030
9Hyperkalemia (HP:0002153)3.48729352
10Infertility (HP:0000789)3.47559305
11Abnormality of the hepatic vasculature (HP:0006707)3.46606871
12Muscle fiber splitting (HP:0003555)3.45075074
13Severe visual impairment (HP:0001141)3.40783050
14Spontaneous abortion (HP:0005268)3.35151447
15Scotoma (HP:0000575)3.29957296
16Azoospermia (HP:0000027)3.26559053
17Rickets (HP:0002748)3.07523173
18Absent/shortened dynein arms (HP:0200106)3.06943710
19Dynein arm defect of respiratory motile cilia (HP:0012255)3.06943710
20Abnormality of the costochondral junction (HP:0000919)3.06910407
21Resting tremor (HP:0002322)3.06588511
22Esophageal varix (HP:0002040)3.05056429
23Complement deficiency (HP:0004431)3.00267114
24Enlarged epiphyses (HP:0010580)2.85435323
25Hypoalphalipoproteinemia (HP:0003233)2.85079602
26Truncal obesity (HP:0001956)2.83229462
27Polycythemia (HP:0001901)2.74053727
28Abnormal spermatogenesis (HP:0008669)2.66058952
29Bony spicule pigmentary retinopathy (HP:0007737)2.65797420
30Hyperlipoproteinemia (HP:0010980)2.63944587
31Abnormality of the nasal mucosa (HP:0000433)2.63316138
32Joint hemorrhage (HP:0005261)2.60182654
33Attenuation of retinal blood vessels (HP:0007843)2.59676746
34Subcapsular cataract (HP:0000523)2.51154421
35Shoulder girdle muscle weakness (HP:0003547)2.50573402
36Nephritis (HP:0000123)2.47690826
37Impulsivity (HP:0100710)2.43815525
38Conjunctival telangiectasia (HP:0000524)2.42327051
39Chronic hepatic failure (HP:0100626)2.42257749
40Tubulointerstitial abnormality (HP:0001969)2.40948787
41Bundle branch block (HP:0011710)2.40820941
42Cone-rod dystrophy (HP:0000548)2.39818007
43Degeneration of the lateral corticospinal tracts (HP:0002314)2.39029591
44Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.39029591
45Rhabdomyolysis (HP:0003201)2.36472641
46Facial shape deformation (HP:0011334)2.35759692
47Potter facies (HP:0002009)2.35759692
48Aplasia/Hypoplasia of the earlobes (HP:0009906)2.34408755
49Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.31795432
50Abnormality of macular pigmentation (HP:0008002)2.31048088
51Delayed epiphyseal ossification (HP:0002663)2.31021553
52Menstrual irregularities (HP:0000858)2.26792279
53Bell-shaped thorax (HP:0001591)2.25446013
54Stage 5 chronic kidney disease (HP:0003774)2.24134541
55Hypercholesterolemia (HP:0003124)2.22890606
56Abnormality of complement system (HP:0005339)2.20472437
57Generalized aminoaciduria (HP:0002909)2.20205872
58Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.18251118
59Atelectasis (HP:0100750)2.18121283
60Rimmed vacuoles (HP:0003805)2.17100221
61Menorrhagia (HP:0000132)2.14651598
62Peripheral hypomyelination (HP:0007182)2.14567717
63Myocardial infarction (HP:0001658)2.13859571
64Heart block (HP:0012722)2.13747380
65Abnormal ciliary motility (HP:0012262)2.13667646
66Spontaneous hematomas (HP:0007420)2.10578101
67Glomerulonephritis (HP:0000099)2.10206247
68Vascular calcification (HP:0004934)2.09417401
69Systemic lupus erythematosus (HP:0002725)2.09393653
70Capillary hemangiomas (HP:0005306)2.05080710
71Widely patent fontanelles and sutures (HP:0004492)2.04333769
72Abnormal atrioventricular conduction (HP:0005150)2.03122569
73Aortic valve stenosis (HP:0001650)2.00429102
74Polar cataract (HP:0010696)1.99645494
75Hemorrhage of the eye (HP:0011885)1.99540644
76Purpura (HP:0000979)1.99039171
77Abnormality of the corticospinal tract (HP:0002492)1.97997987
78Hypergonadotropic hypogonadism (HP:0000815)1.97988886
79Insulin-resistant diabetes mellitus (HP:0000831)1.97552333
80Intellectual disability, moderate (HP:0002342)1.95829703
81Prolonged bleeding time (HP:0003010)1.94222215
82Aortic aneurysm (HP:0004942)1.92027453
83Exercise-induced myalgia (HP:0003738)1.90334327
84Gonadal dysgenesis (HP:0000133)1.89287809
85Atrial fibrillation (HP:0005110)1.86951003
86Amelogenesis imperfecta (HP:0000705)1.86627536
87Wide cranial sutures (HP:0010537)1.86492857
88Wrist flexion contracture (HP:0001239)1.85216645
89Hypolipoproteinemia (HP:0010981)1.84921609
90Acanthosis nigricans (HP:0000956)1.84472817
91Difficulty climbing stairs (HP:0003551)1.83422060
92Thin bony cortex (HP:0002753)1.83380281
93Hypertriglyceridemia (HP:0002155)1.82756426
94Bulbar palsy (HP:0001283)1.82287700
95Prolonged partial thromboplastin time (HP:0003645)1.82170303
96Cardiovascular calcification (HP:0011915)1.79894751
97Abnormality of monocarboxylic acid metabolism (HP:0010996)1.78417080
98Vertebral clefting (HP:0008428)1.77748467
99Hand muscle atrophy (HP:0009130)1.77001637
100Abnormality of the intrinsic pathway (HP:0010989)1.76874588

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE17.73017228
2PNCK5.52224519
3PLK43.86681390
4CDK193.57335295
5MET3.06960907
6STK38L3.00768422
7ACVR1B2.95577335
8STK382.66379715
9KDR2.63287636
10CAMK1G2.26215042
11PTK2B2.09499932
12TESK12.04480313
13KSR21.83547231
14PLK21.65601396
15MST1R1.63481143
16PRKD31.61448024
17LATS11.60655893
18INSRR1.52026476
19DDR21.49911363
20MAP3K21.47782734
21TGFBR21.35998911
22WNK11.33740555
23MAPK151.27729206
24MAP3K131.24516697
25STK391.22110999
26PIK3CG1.19659423
27BMX1.18536765
28ARAF1.16648269
29LATS21.15075277
30BRD41.15073429
31MYLK1.05467174
32PDPK11.03481289
33WNK41.01779984
34NEK60.97023169
35NTRK30.95738710
36NEK90.95408375
37FER0.88363877
38TTN0.81571224
39BRAF0.78562404
40TYRO30.76181943
41PTK20.72204563
42MAP3K90.72135088
43RIPK10.69601754
44FES0.67990727
45CAMK10.66528416
46MAP3K10.64955315
47PDGFRB0.64715575
48PRKAA20.62564767
49STK30.61582610
50PRKG10.60638998
51CSF1R0.59442603
52RET0.57858484
53KIT0.56775005
54PDK10.54689079
55MAP3K70.54541077
56BMPR1B0.51534025
57OBSCN0.48829001
58CDK120.48801597
59CDK70.47608348
60TGFBR10.46271858
61PLK10.46265399
62MOS0.45001581
63PINK10.44067673
64STK240.42367472
65PRKG20.41697931
66ROCK10.40980336
67ABL20.40959479
68OXSR10.39007788
69PRKD10.36238303
70RAF10.36050627
71TTK0.35757410
72RPS6KA20.35454543
73EGFR0.34117903
74PDGFRA0.33653613
75DYRK1B0.33056652
76IGF1R0.32933706
77MAPK10.32158515
78CDK40.31997755
79DMPK0.30744986
80MAP2K10.30535558
81FGR0.29852357
82SGK10.29072052
83TAF10.28270110
84MAP3K80.26794356
85CCNB10.24573412
86MARK20.24327238
87TEC0.23857400
88RPS6KL10.22862841
89RPS6KC10.22862841
90MTOR0.22027595
91CHEK10.20731062
92MAP2K20.20033519
93EPHA40.19828098
94RPS6KA10.19291449
95AURKA0.18993370
96RPS6KA60.17272102
97CDK30.16704108
98MUSK0.16547211
99PKN10.16366301
100PAK20.16110224

Predicted pathways (KEGG)

RankGene SetZ-score
1Dorso-ventral axis formation_Homo sapiens_hsa043203.87088097
2Fatty acid biosynthesis_Homo sapiens_hsa000613.39635854
3Fatty acid degradation_Homo sapiens_hsa000712.82940612
4Complement and coagulation cascades_Homo sapiens_hsa046102.62642033
5Glycosaminoglycan degradation_Homo sapiens_hsa005312.52624058
6ECM-receptor interaction_Homo sapiens_hsa045122.21329755
7Phenylalanine metabolism_Homo sapiens_hsa003602.15620621
8PPAR signaling pathway_Homo sapiens_hsa033201.99207615
9ABC transporters_Homo sapiens_hsa020101.87665121
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.84481509
11Oocyte meiosis_Homo sapiens_hsa041141.80808874
12Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.74402794
13Fatty acid metabolism_Homo sapiens_hsa012121.62443674
14Olfactory transduction_Homo sapiens_hsa047401.56974800
15Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.53125225
16Glycerophospholipid metabolism_Homo sapiens_hsa005641.52145386
17Circadian rhythm_Homo sapiens_hsa047101.50096551
18Regulation of autophagy_Homo sapiens_hsa041401.49322664
19Retinol metabolism_Homo sapiens_hsa008301.48049217
20Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.46954558
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.44521006
22Tyrosine metabolism_Homo sapiens_hsa003501.41873434
23Sulfur relay system_Homo sapiens_hsa041221.37074175
24Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.36812335
25Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.33078203
26Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.23205648
27Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.22614105
28Vascular smooth muscle contraction_Homo sapiens_hsa042701.19085740
29Primary bile acid biosynthesis_Homo sapiens_hsa001201.18052734
30Arginine and proline metabolism_Homo sapiens_hsa003301.16857940
31Propanoate metabolism_Homo sapiens_hsa006401.16159344
32Focal adhesion_Homo sapiens_hsa045101.13349475
33Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.12178795
34beta-Alanine metabolism_Homo sapiens_hsa004101.11196015
35Basal transcription factors_Homo sapiens_hsa030221.09086048
36Dilated cardiomyopathy_Homo sapiens_hsa054141.08110619
37Arginine biosynthesis_Homo sapiens_hsa002201.07639025
38Prion diseases_Homo sapiens_hsa050201.05738048
39Glycerolipid metabolism_Homo sapiens_hsa005611.03761914
40Mismatch repair_Homo sapiens_hsa034301.02560927
41Histidine metabolism_Homo sapiens_hsa003401.01055568
42RNA transport_Homo sapiens_hsa030130.96614092
43TGF-beta signaling pathway_Homo sapiens_hsa043500.93033505
44Bile secretion_Homo sapiens_hsa049760.92901416
45Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.91029888
46Inositol phosphate metabolism_Homo sapiens_hsa005620.90693814
47Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.90511345
48Endocytosis_Homo sapiens_hsa041440.89046652
49Folate biosynthesis_Homo sapiens_hsa007900.88050446
50Base excision repair_Homo sapiens_hsa034100.87684137
51cGMP-PKG signaling pathway_Homo sapiens_hsa040220.87129230
52Calcium signaling pathway_Homo sapiens_hsa040200.87079714
53Butanoate metabolism_Homo sapiens_hsa006500.84341075
54Protein digestion and absorption_Homo sapiens_hsa049740.83462998
55Adipocytokine signaling pathway_Homo sapiens_hsa049200.82237547
56Cell cycle_Homo sapiens_hsa041100.81229106
57Taste transduction_Homo sapiens_hsa047420.78877197
58Steroid hormone biosynthesis_Homo sapiens_hsa001400.76981417
59Platelet activation_Homo sapiens_hsa046110.76359930
60Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.75617921
61Gap junction_Homo sapiens_hsa045400.75449002
62Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.73771450
63Ovarian steroidogenesis_Homo sapiens_hsa049130.73074843
64VEGF signaling pathway_Homo sapiens_hsa043700.72290166
65Fanconi anemia pathway_Homo sapiens_hsa034600.70652871
66Adherens junction_Homo sapiens_hsa045200.69168433
67Chemical carcinogenesis_Homo sapiens_hsa052040.68946673
68Fat digestion and absorption_Homo sapiens_hsa049750.68461990
69Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.67953130
70Pyruvate metabolism_Homo sapiens_hsa006200.67907792
71Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.67397351
72Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.67147604
73Phospholipase D signaling pathway_Homo sapiens_hsa040720.65287014
74Tryptophan metabolism_Homo sapiens_hsa003800.61812600
75Renin secretion_Homo sapiens_hsa049240.61516637
76Tight junction_Homo sapiens_hsa045300.59856680
77Phosphatidylinositol signaling system_Homo sapiens_hsa040700.57848125
78Rap1 signaling pathway_Homo sapiens_hsa040150.57096539
79Amoebiasis_Homo sapiens_hsa051460.53900555
80mTOR signaling pathway_Homo sapiens_hsa041500.53356542
81PI3K-Akt signaling pathway_Homo sapiens_hsa041510.52961738
82Notch signaling pathway_Homo sapiens_hsa043300.51406986
83Fatty acid elongation_Homo sapiens_hsa000620.50672398
84Thyroid hormone signaling pathway_Homo sapiens_hsa049190.50527582
85Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.49879382
86Linoleic acid metabolism_Homo sapiens_hsa005910.48117211
87cAMP signaling pathway_Homo sapiens_hsa040240.47649010
88Regulation of actin cytoskeleton_Homo sapiens_hsa048100.45978123
89Starch and sucrose metabolism_Homo sapiens_hsa005000.43045874
90Arachidonic acid metabolism_Homo sapiens_hsa005900.40595755
91Serotonergic synapse_Homo sapiens_hsa047260.39286905
92Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.38994103
93Type II diabetes mellitus_Homo sapiens_hsa049300.38236441
94Aldosterone synthesis and secretion_Homo sapiens_hsa049250.36111511
95AMPK signaling pathway_Homo sapiens_hsa041520.35993297
96Lysine degradation_Homo sapiens_hsa003100.34645339
97Homologous recombination_Homo sapiens_hsa034400.32972745
98Drug metabolism - other enzymes_Homo sapiens_hsa009830.31568062
99Sphingolipid metabolism_Homo sapiens_hsa006000.31375403
100Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.30923742

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