TDRD12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1melanin metabolic process (GO:0006582)9.73199829
2secondary metabolite biosynthetic process (GO:0044550)9.54941118
3* piRNA metabolic process (GO:0034587)6.12541457
4synapsis (GO:0007129)5.43875553
5mitotic metaphase plate congression (GO:0007080)5.02418316
6synaptonemal complex assembly (GO:0007130)4.90027888
7nuclear pore organization (GO:0006999)4.82997226
8nuclear pore complex assembly (GO:0051292)4.81929313
9melanosome organization (GO:0032438)4.74236745
10DNA replication-dependent nucleosome assembly (GO:0006335)4.72967868
11DNA replication-dependent nucleosome organization (GO:0034723)4.72967868
12ketone body metabolic process (GO:1902224)4.67287683
13synaptonemal complex organization (GO:0070193)4.63901683
14protein localization to kinetochore (GO:0034501)4.62062290
15attachment of spindle microtubules to kinetochore (GO:0008608)4.54788859
16phenol-containing compound biosynthetic process (GO:0046189)4.51397762
17regulation of DNA endoreduplication (GO:0032875)4.45852444
18pigment granule organization (GO:0048753)4.44546233
19metaphase plate congression (GO:0051310)4.34698789
20* male meiosis (GO:0007140)4.32267805
21regulation of meiosis I (GO:0060631)4.30471278
22regulation of gene silencing by RNA (GO:0060966)4.29941482
23regulation of posttranscriptional gene silencing (GO:0060147)4.29941482
24regulation of gene silencing by miRNA (GO:0060964)4.29941482
25* DNA methylation involved in gamete generation (GO:0043046)4.29855179
26mitotic nuclear envelope disassembly (GO:0007077)4.25156050
27mitotic sister chromatid segregation (GO:0000070)4.22069368
28protein localization to chromosome, centromeric region (GO:0071459)4.19106997
29protein K6-linked ubiquitination (GO:0085020)4.18889030
30mitotic chromosome condensation (GO:0007076)4.16366910
31DNA replication initiation (GO:0006270)4.13935261
32meiotic chromosome segregation (GO:0045132)4.03895409
33proteasome assembly (GO:0043248)4.02235093
34cullin deneddylation (GO:0010388)4.00069794
35nuclear envelope disassembly (GO:0051081)3.99199303
36membrane disassembly (GO:0030397)3.99199303
37DNA replication checkpoint (GO:0000076)3.94316675
38negative regulation of meiosis (GO:0045835)3.90772176
39chromatin remodeling at centromere (GO:0031055)3.89802205
40developmental pigmentation (GO:0048066)3.89576115
41chromosome organization involved in meiosis (GO:0070192)3.89091526
42somatic diversification of immune receptors via somatic mutation (GO:0002566)3.87401129
43somatic hypermutation of immunoglobulin genes (GO:0016446)3.87401129
44histone exchange (GO:0043486)3.84116910
45* meiotic nuclear division (GO:0007126)3.83107973
46meiotic cell cycle (GO:0051321)3.82620544
47establishment of chromosome localization (GO:0051303)3.79854510
48regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.76386789
49inositol phosphate catabolic process (GO:0071545)3.75582264
50regulation of centriole replication (GO:0046599)3.72828106
51protein deneddylation (GO:0000338)3.72392252
52regulation of helicase activity (GO:0051095)3.71707861
53pigment biosynthetic process (GO:0046148)3.69100400
54regulation of histone H3-K9 methylation (GO:0051570)3.65003321
55positive regulation of chromosome segregation (GO:0051984)3.63284204
56CENP-A containing nucleosome assembly (GO:0034080)3.62555126
57DNA deamination (GO:0045006)3.61323000
58sister chromatid segregation (GO:0000819)3.59510411
59binding of sperm to zona pellucida (GO:0007339)3.58013537
60pore complex assembly (GO:0046931)3.57762277
61regulation of chromosome segregation (GO:0051983)3.54762645
62phosphorylated carbohydrate dephosphorylation (GO:0046838)3.53429673
63inositol phosphate dephosphorylation (GO:0046855)3.53429673
64regulation of centrosome cycle (GO:0046605)3.52631421
65DNA replication-independent nucleosome assembly (GO:0006336)3.52348727
66DNA replication-independent nucleosome organization (GO:0034724)3.52348727
67ribosome assembly (GO:0042255)3.51925163
68DNA strand elongation involved in DNA replication (GO:0006271)3.51773964
69meiotic cell cycle process (GO:1903046)3.51575962
70fusion of sperm to egg plasma membrane (GO:0007342)3.47939277
71melanocyte differentiation (GO:0030318)3.44035658
72detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.43365616
73folic acid-containing compound biosynthetic process (GO:0009396)3.43257888
74negative regulation of DNA-dependent DNA replication (GO:2000104)3.43113683
75regulation of spindle organization (GO:0090224)3.41986210
76positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.41742567
77positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.41742567
78positive regulation of mitotic sister chromatid separation (GO:1901970)3.41742567
79regulation of sister chromatid cohesion (GO:0007063)3.41225782
80negative regulation of chromosome segregation (GO:0051985)3.41199974
81kinetochore organization (GO:0051383)3.40962656
82heterochromatin organization (GO:0070828)3.39059031
83male meiosis I (GO:0007141)3.38189235
84sister chromatid cohesion (GO:0007062)3.36765823
85* gene silencing by RNA (GO:0031047)3.36550288
86histone H2A monoubiquitination (GO:0035518)3.35791630
87negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.35344288
88spindle checkpoint (GO:0031577)3.32594374
89maturation of 5.8S rRNA (GO:0000460)3.31784237
90resolution of meiotic recombination intermediates (GO:0000712)3.31504863
91DNA strand elongation (GO:0022616)3.31366719
92pigment cell differentiation (GO:0050931)3.30570147
93negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.30260309
94negative regulation of sister chromatid segregation (GO:0033046)3.30260309
95negative regulation of mitotic sister chromatid separation (GO:2000816)3.30260309
96negative regulation of mitotic sister chromatid segregation (GO:0033048)3.30260309
97negative regulation of histone methylation (GO:0031061)3.29798297
98protein localization to chromosome (GO:0034502)3.28038993
99acrosome reaction (GO:0007340)3.27275158
100regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.26329635
101negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)3.25248170
102regulation of mitotic spindle organization (GO:0060236)3.25200799
103chromosome segregation (GO:0007059)3.24428664
104sperm-egg recognition (GO:0035036)3.23710778
105regulation of telomere maintenance via telomerase (GO:0032210)3.23363026
106mitotic spindle checkpoint (GO:0071174)3.23176672
107histone H4-K12 acetylation (GO:0043983)3.22614734
108regulation of mitotic metaphase/anaphase transition (GO:0030071)3.22218334
109polyol catabolic process (GO:0046174)3.20501998
110DNA unwinding involved in DNA replication (GO:0006268)3.20385657
111response to pheromone (GO:0019236)3.20149181
112kinetochore assembly (GO:0051382)3.19997149
113mismatch repair (GO:0006298)3.19837688
114regulation of double-strand break repair via homologous recombination (GO:0010569)3.19417393
115female gamete generation (GO:0007292)3.18691915
116spindle assembly checkpoint (GO:0071173)3.17660494
117regulation of mitotic sister chromatid separation (GO:0010965)3.17471264
118regulation of mitotic sister chromatid segregation (GO:0033047)3.17471264
119regulation of sister chromatid segregation (GO:0033045)3.17471264
120mitotic spindle assembly checkpoint (GO:0007094)3.16823607
121telomere maintenance via semi-conservative replication (GO:0032201)3.16492120
122reciprocal DNA recombination (GO:0035825)3.15755746
123reciprocal meiotic recombination (GO:0007131)3.15755746
124secondary metabolic process (GO:0019748)3.15679849
125microtubule depolymerization (GO:0007019)3.13898598
126chromatin assembly or disassembly (GO:0006333)3.11417192
127nucleobase biosynthetic process (GO:0046112)3.11340605
128meiosis I (GO:0007127)3.11315216
129DNA geometric change (GO:0032392)3.10530981
130recombinational repair (GO:0000725)3.07767618
131pigment metabolic process (GO:0042440)3.07022781
132signal peptide processing (GO:0006465)3.06888365
133double-strand break repair via homologous recombination (GO:0000724)3.05191683
134centrosome duplication (GO:0051298)3.02953729
135tyrosine metabolic process (GO:0006570)2.97334899
136regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.91715897
137regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.91715897
138plasma membrane fusion (GO:0045026)2.89441654
139protein K11-linked deubiquitination (GO:0035871)2.81021248
140dopamine transport (GO:0015872)2.78587910
141regulation of neurotransmitter uptake (GO:0051580)2.78017340
142respiratory chain complex IV assembly (GO:0008535)2.76297600
143auditory receptor cell stereocilium organization (GO:0060088)2.75113681
144negative regulation of interleukin-1 beta production (GO:0032691)2.72412320
145protein complex biogenesis (GO:0070271)2.71938938
146replication fork processing (GO:0031297)2.70963615
147mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.67601596
148mitochondrial respiratory chain complex I assembly (GO:0032981)2.67601596
149NADH dehydrogenase complex assembly (GO:0010257)2.67601596
150behavioral response to nicotine (GO:0035095)2.67531144
151positive regulation of meiosis (GO:0045836)2.67188072
152somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.66703239
153isotype switching (GO:0045190)2.66703239
154somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.66703239
155neuroepithelial cell differentiation (GO:0060563)2.66052713
156mannosylation (GO:0097502)2.65920534
157regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.65162960
158regulation of mitotic spindle checkpoint (GO:1903504)2.65162960
159endosome to melanosome transport (GO:0035646)2.64807289
160endosome to pigment granule transport (GO:0043485)2.64807289
161regulation of nuclear cell cycle DNA replication (GO:0033262)2.64458307
162RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.61774706
163mitochondrial respiratory chain complex assembly (GO:0033108)2.61033714
164positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.60518856
165melanosome transport (GO:0032402)2.59974958
166L-fucose catabolic process (GO:0042355)2.56289172
167fucose catabolic process (GO:0019317)2.56289172
168L-fucose metabolic process (GO:0042354)2.56289172
169regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.54114036
170platelet dense granule organization (GO:0060155)2.53836248
171lactate metabolic process (GO:0006089)2.53603822
172negative regulation of telomere maintenance (GO:0032205)2.53132238
173negative regulation of acute inflammatory response (GO:0002674)2.51608203
174regulation of hexokinase activity (GO:1903299)2.50623171
175regulation of glucokinase activity (GO:0033131)2.50623171
176tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.48216877
177RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.48216877
178cornea development in camera-type eye (GO:0061303)2.47727470
179positive regulation of meiotic cell cycle (GO:0051446)2.47111358
180establishment of melanosome localization (GO:0032401)2.46884931
181melanin biosynthetic process (GO:0042438)10.7794113

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.41952057
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.57464533
3MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.44913808
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.61548922
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.59383244
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.28590736
7ZNF274_21170338_ChIP-Seq_K562_Hela3.24666435
8VDR_22108803_ChIP-Seq_LS180_Human3.12781740
9KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.93663812
10KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.93663812
11KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.93663812
12MYC_19079543_ChIP-ChIP_MESCs_Mouse2.85579104
13SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.69474016
14SALL1_21062744_ChIP-ChIP_HESCs_Human2.65870071
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.51680391
16FUS_26573619_Chip-Seq_HEK293_Human2.41303934
17POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.37914023
18* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.36290867
19NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.34249286
20NANOG_18555785_ChIP-Seq_MESCs_Mouse2.32359616
21FLI1_27457419_Chip-Seq_LIVER_Mouse2.28117468
22MYC_18358816_ChIP-ChIP_MESCs_Mouse2.27175840
23AR_21909140_ChIP-Seq_LNCAP_Human2.25431865
24ZFP57_27257070_Chip-Seq_ESCs_Mouse2.23502520
25MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.23420443
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.22790399
27POU3F2_20337985_ChIP-ChIP_501MEL_Human2.22680522
28GBX2_23144817_ChIP-Seq_PC3_Human2.19209962
29NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.18710312
30NELFA_20434984_ChIP-Seq_ESCs_Mouse2.12287479
31KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.10379412
32POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.07421683
33MYCN_18555785_ChIP-Seq_MESCs_Mouse2.05635435
34EST1_17652178_ChIP-ChIP_JURKAT_Human2.04954974
35ELF1_17652178_ChIP-ChIP_JURKAT_Human2.03417953
36IGF1R_20145208_ChIP-Seq_DFB_Human2.03369561
37SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.01049828
38JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.98909024
39EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.98385926
40MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.95267240
41PCGF2_27294783_Chip-Seq_ESCs_Mouse1.94014461
42RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.93810863
43ETS1_20019798_ChIP-Seq_JURKAT_Human1.89702093
44POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.87850556
45STAT3_1855785_ChIP-Seq_MESCs_Mouse1.87410219
46SRF_21415370_ChIP-Seq_HL-1_Mouse1.80756335
47EWS_26573619_Chip-Seq_HEK293_Human1.78360918
48TCF3_18692474_ChIP-Seq_MESCs_Mouse1.78018450
49GABP_17652178_ChIP-ChIP_JURKAT_Human1.77697602
50TCF3_18692474_ChIP-Seq_MEFs_Mouse1.77534965
51MYC_18940864_ChIP-ChIP_HL60_Human1.77525736
52E2F1_21310950_ChIP-Seq_MCF-7_Human1.77380663
53E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.76803701
54SOX2_18555785_ChIP-Seq_MESCs_Mouse1.76420280
55CREB1_15753290_ChIP-ChIP_HEK293T_Human1.74103841
56ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.72017066
57E2F1_18555785_ChIP-Seq_MESCs_Mouse1.71730063
58ER_23166858_ChIP-Seq_MCF-7_Human1.71664188
59P300_19829295_ChIP-Seq_ESCs_Human1.66919215
60NFE2_27457419_Chip-Seq_LIVER_Mouse1.66288542
61CTBP2_25329375_ChIP-Seq_LNCAP_Human1.63937394
62XRN2_22483619_ChIP-Seq_HELA_Human1.63853680
63EZH2_27294783_Chip-Seq_NPCs_Mouse1.63521343
64SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.59039255
65EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.58208391
66HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.57388607
67SUZ12_27294783_Chip-Seq_NPCs_Mouse1.55522957
68UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.54116739
69SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.53063205
70AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.52861960
71FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.49778837
72CTBP1_25329375_ChIP-Seq_LNCAP_Human1.49452894
73VDR_23849224_ChIP-Seq_CD4+_Human1.48414216
74NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.48376012
75SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.44219761
76TAF15_26573619_Chip-Seq_HEK293_Human1.43414760
77FOXA1_27270436_Chip-Seq_PROSTATE_Human1.42573185
78FOXA1_25329375_ChIP-Seq_VCAP_Human1.42573185
79PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.40336681
80NOTCH1_21737748_ChIP-Seq_TLL_Human1.37723369
81GABP_19822575_ChIP-Seq_HepG2_Human1.37619296
82ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.37606202
83KLF4_18555785_ChIP-Seq_MESCs_Mouse1.37095088
84DCP1A_22483619_ChIP-Seq_HELA_Human1.36949522
85YY1_21170310_ChIP-Seq_MESCs_Mouse1.35277092
86NANOG_21062744_ChIP-ChIP_HESCs_Human1.35209159
87TP53_22573176_ChIP-Seq_HFKS_Human1.34315817
88MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.32552833
89CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.32504020
90TTF2_22483619_ChIP-Seq_HELA_Human1.32217029
91NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.31923811
92IRF1_19129219_ChIP-ChIP_H3396_Human1.30235070
93KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.29917386
94FOXA1_21572438_ChIP-Seq_LNCaP_Human1.29556345
95TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.29456167
96CRX_20693478_ChIP-Seq_RETINA_Mouse1.28745718
97GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.28608744
98FOXP3_21729870_ChIP-Seq_TREG_Human1.28587179
99STAT3_23295773_ChIP-Seq_U87_Human1.28439273
100PCGF2_27294783_Chip-Seq_NPCs_Mouse1.26547504
101CBP_20019798_ChIP-Seq_JUKART_Human1.26389521
102IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.26389521
103YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.26338311
104NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.26268397
105BCAT_22108803_ChIP-Seq_LS180_Human1.25119658
106HOXB7_26014856_ChIP-Seq_BT474_Human1.25029818
107ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.24709814
108POU5F1_16518401_ChIP-PET_MESCs_Mouse1.24048588
109SOX2_18692474_ChIP-Seq_MESCs_Mouse1.23957698
110THAP11_20581084_ChIP-Seq_MESCs_Mouse1.23951379
111KDM5A_27292631_Chip-Seq_BREAST_Human1.21075932
112NANOG_18692474_ChIP-Seq_MESCs_Mouse1.20950437
113ZFX_18555785_ChIP-Seq_MESCs_Mouse1.19939543
114STAT3_18555785_Chip-Seq_ESCs_Mouse1.19073348
115MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.18758211
116NANOG_18692474_ChIP-Seq_MEFs_Mouse1.18640743
117TCF4_23295773_ChIP-Seq_U87_Human1.18336166
118CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.17987237
119AUTS2_25519132_ChIP-Seq_293T-REX_Human1.16679997
120POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.15962474
121NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.15951469
122SOX2_18692474_ChIP-Seq_MEFs_Mouse1.15893668
123SMAD4_21799915_ChIP-Seq_A2780_Human1.14588102
124AR_25329375_ChIP-Seq_VCAP_Human1.14013883
125NANOG_19829295_ChIP-Seq_ESCs_Human1.13823720
126SOX2_19829295_ChIP-Seq_ESCs_Human1.13823720
127ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.13494109
128TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.12533797
129RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.12080948
130CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.11914289
131SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.11649293
132AR_20517297_ChIP-Seq_VCAP_Human1.09972026
133NCOR_22424771_ChIP-Seq_293T_Human1.08535010
134SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.08265292
135TP63_19390658_ChIP-ChIP_HaCaT_Human1.08051029
136NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.07596272
137GATA1_26923725_Chip-Seq_HPCs_Mouse1.07427399
138P53_22387025_ChIP-Seq_ESCs_Mouse1.06522180
139OCT4_21477851_ChIP-Seq_ESCs_Mouse1.05569463
140KLF5_20875108_ChIP-Seq_MESCs_Mouse1.05421744
141HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.05344854
142HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.05229661
143KAP1_27257070_Chip-Seq_ESCs_Mouse1.04890806
144SOX2_18555785_Chip-Seq_ESCs_Mouse1.04107201
145P300_18555785_Chip-Seq_ESCs_Mouse1.04056526
146E2F1_18555785_Chip-Seq_ESCs_Mouse1.02984551
147CTCF_18555785_Chip-Seq_ESCs_Mouse1.02672024
148NANOG_18555785_Chip-Seq_ESCs_Mouse1.02316678
149CDX2_22108803_ChIP-Seq_LS180_Human1.02124809
150TCF4_22108803_ChIP-Seq_LS180_Human1.01776406
151SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.01611692
152GATA3_21878914_ChIP-Seq_MCF-7_Human1.01361373
153GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.00753414
154SMAD4_21741376_ChIP-Seq_EPCs_Human1.00428323
155RBPJ_22232070_ChIP-Seq_NCS_Mouse1.00274119
156* TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.00003732
157TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.99818316
158HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.99210287
159EGR1_23403033_ChIP-Seq_LIVER_Mouse0.98916311
160NMYC_18555785_Chip-Seq_ESCs_Mouse0.98794380
161DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.97400407
162RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.97316437
163KAP1_22055183_ChIP-Seq_ESCs_Mouse0.97093268
164KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.96606238
165ESR1_15608294_ChIP-ChIP_MCF-7_Human0.96411056
166CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.94149421
167E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.92108213
168OCT4_18692474_ChIP-Seq_MEFs_Mouse0.91273511
169EGR1_19374776_ChIP-ChIP_THP-1_Human0.91002690
170SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.90436278
171POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.88503588
172PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.86744898
173ELK1_19687146_ChIP-ChIP_HELA_Human0.86688511
174NANOG_16518401_ChIP-PET_MESCs_Mouse0.86388014
175PADI4_21655091_ChIP-ChIP_MCF-7_Human0.86070949
176CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.85730393

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000372_irregular_coat_pigmentation8.56985240
2MP0005171_absent_coat_pigmentation4.98910611
3MP0010094_abnormal_chromosome_stability4.81749315
4MP0003693_abnormal_embryo_hatching4.65053885
5MP0008877_abnormal_DNA_methylation4.62530661
6MP0005408_hypopigmentation4.51478958
7MP0008057_abnormal_DNA_replication4.43111592
8MP0005075_abnormal_melanosome_morpholog4.36356926
9MP0003111_abnormal_nucleus_morphology4.22110317
10MP0000015_abnormal_ear_pigmentation4.15634004
11MP0004957_abnormal_blastocyst_morpholog4.03503202
12MP0003077_abnormal_cell_cycle3.75548493
13MP0008058_abnormal_DNA_repair3.33110766
14MP0003718_maternal_effect3.25183003
15MP0002095_abnormal_skin_pigmentation3.20586960
16MP0005174_abnormal_tail_pigmentation3.15031416
17MP0002938_white_spotting2.93740292
18MP0002653_abnormal_ependyma_morphology2.90161971
19MP0001929_abnormal_gametogenesis2.85822951
20MP0002210_abnormal_sex_determination2.80253253
21MP0000371_diluted_coat_color2.76013860
22MP0004381_abnormal_hair_follicle2.71441700
23MP0005410_abnormal_fertilization2.69308100
24MP0001324_abnormal_eye_pigmentation2.45169552
25MP0008932_abnormal_embryonic_tissue2.41820745
26MP0003806_abnormal_nucleotide_metabolis2.38172137
27MP0001145_abnormal_male_reproductive2.34107420
28MP0003123_paternal_imprinting2.29017719
29MP0001730_embryonic_growth_arrest2.28056659
30MP0008007_abnormal_cellular_replicative2.25114602
31MP0000653_abnormal_sex_gland2.22652574
32MP0000350_abnormal_cell_proliferation2.17305112
33MP0003786_premature_aging2.16226456
34MP0003698_abnormal_male_reproductive2.13374245
35MP0010352_gastrointestinal_tract_polyps2.07839490
36MP0004133_heterotaxia1.97737097
37MP0010307_abnormal_tumor_latency1.87953489
38MP0005380_embryogenesis_phenotype1.82130779
39MP0001672_abnormal_embryogenesis/_devel1.82130779
40MP0000569_abnormal_digit_pigmentation1.81750963
41MP0005377_hearing/vestibular/ear_phenot1.81584076
42MP0003878_abnormal_ear_physiology1.81584076
43MP0002638_abnormal_pupillary_reflex1.80871163
44MP0002085_abnormal_embryonic_tissue1.80611720
45MP0003890_abnormal_embryonic-extraembry1.77886454
46MP0002084_abnormal_developmental_patter1.75044127
47MP0001697_abnormal_embryo_size1.70024999
48MP0002075_abnormal_coat/hair_pigmentati1.64896973
49MP0002161_abnormal_fertility/fecundity1.63498988
50MP0004885_abnormal_endolymph1.61277299
51MP0005253_abnormal_eye_physiology1.60916950
52MP0003121_genomic_imprinting1.60530334
53MP0006292_abnormal_olfactory_placode1.57411747
54MP0001119_abnormal_female_reproductive1.51066313
55MP0003283_abnormal_digestive_organ1.49643915
56MP0005551_abnormal_eye_electrophysiolog1.44952769
57MP0003984_embryonic_growth_retardation1.44312654
58MP0003646_muscle_fatigue1.43603938
59MP0002088_abnormal_embryonic_growth/wei1.40923167
60MP0002080_prenatal_lethality1.40920547
61MP0002086_abnormal_extraembryonic_tissu1.39238357
62MP0001186_pigmentation_phenotype1.36819728
63MP0003699_abnormal_female_reproductive1.35860939
64MP0002090_abnormal_vision1.30553900
65MP0005395_other_phenotype1.30550016
66MP0004197_abnormal_fetal_growth/weight/1.29559595
67MP0002160_abnormal_reproductive_system1.27420146
68MP0003787_abnormal_imprinting1.25826149
69MP0003119_abnormal_digestive_system1.21737696
70MP0000313_abnormal_cell_death1.20470834
71MP0003315_abnormal_perineum_morphology1.20400732
72MP0009046_muscle_twitch1.16249662
73MP0001293_anophthalmia1.15297306
74MP0004264_abnormal_extraembryonic_tissu1.15106018
75MP0008995_early_reproductive_senescence1.14749248
76MP0005389_reproductive_system_phenotype1.14473205
77MP0002837_dystrophic_cardiac_calcinosis1.13891145
78MP0002019_abnormal_tumor_incidence1.13852374
79MP0003136_yellow_coat_color1.07739233
80MP0005257_abnormal_intraocular_pressure1.07202902
81MP0003195_calcinosis1.06422224
82MP0000427_abnormal_hair_cycle1.04831860
83MP0002877_abnormal_melanocyte_morpholog1.02218017
84MP0003941_abnormal_skin_development1.01856832
85MP0005076_abnormal_cell_differentiation1.00202408
86MP0004147_increased_porphyrin_level1.00137689
87MP0005266_abnormal_metabolism0.99518242
88MP0002736_abnormal_nociception_after0.97872378
89MP0003937_abnormal_limbs/digits/tail_de0.96818302
90MP0010030_abnormal_orbit_morphology0.92950315
91MP0001849_ear_inflammation0.91224132
92MP0002909_abnormal_adrenal_gland0.91216732
93MP0000490_abnormal_crypts_of0.87244936
94MP0001968_abnormal_touch/_nociception0.86435384
95MP0006036_abnormal_mitochondrial_physio0.85777700
96MP0004142_abnormal_muscle_tone0.85323887
97MP0004484_altered_response_of0.85177507
98MP0005197_abnormal_uvea_morphology0.83620849
99MP0000647_abnormal_sebaceous_gland0.82732585
100MP0001919_abnormal_reproductive_system0.80992088
101MP0001984_abnormal_olfaction0.80803892
102MP0006072_abnormal_retinal_apoptosis0.80457819
103MP0001485_abnormal_pinna_reflex0.80065666
104MP0002177_abnormal_outer_ear0.78318285
105MP0003705_abnormal_hypodermis_morpholog0.76365454
106MP0000358_abnormal_cell_content/0.76181165
107MP0003936_abnormal_reproductive_system0.75954296
108MP0002269_muscular_atrophy0.75849225
109MP0005384_cellular_phenotype0.75757913
110MP0008872_abnormal_physiological_respon0.74927000
111MP0002249_abnormal_larynx_morphology0.74791925
112MP0003861_abnormal_nervous_system0.74603732
113MP0003950_abnormal_plasma_membrane0.73951314
114MP0005621_abnormal_cell_physiology0.73716119
115MP0002876_abnormal_thyroid_physiology0.72706773
116MP0001986_abnormal_taste_sensitivity0.72420630
117MP0002111_abnormal_tail_morphology0.69509328
118MP0002272_abnormal_nervous_system0.68468877
119MP0001915_intracranial_hemorrhage0.68080753
120MP0005195_abnormal_posterior_eye0.67904823
121MP0004924_abnormal_behavior0.66920358
122MP0005386_behavior/neurological_phenoty0.66920358
123MP0005023_abnormal_wound_healing0.66702376
124MP0000383_abnormal_hair_follicle0.66587682
125MP0009745_abnormal_behavioral_response0.66459111
126MP0002229_neurodegeneration0.66207537
127MP0005646_abnormal_pituitary_gland0.65916760
128MP0003567_abnormal_fetal_cardiomyocyte0.64882814
129MP0000432_abnormal_head_morphology0.64683547
130MP0005645_abnormal_hypothalamus_physiol0.63692457
131MP0004233_abnormal_muscle_weight0.63325354
132MP0001286_abnormal_eye_development0.63087253
133MP0004043_abnormal_pH_regulation0.60098423
134MP0003186_abnormal_redox_activity0.58936219
135MP0005391_vision/eye_phenotype0.58842057
136MP0009703_decreased_birth_body0.58669779
137MP0010678_abnormal_skin_adnexa0.53954062
138MP0003755_abnormal_palate_morphology0.53367537
139MP0000631_abnormal_neuroendocrine_gland0.53311770
140MP0003566_abnormal_cell_adhesion0.52189995
141MP0005187_abnormal_penis_morphology0.52021920
142MP0002092_abnormal_eye_morphology0.51869807
143MP0002928_abnormal_bile_duct0.50952398
144MP0002114_abnormal_axial_skeleton0.50615095
145MP0005379_endocrine/exocrine_gland_phen0.50595352
146MP0002127_abnormal_cardiovascular_syste0.48613311
147MP0009672_abnormal_birth_weight0.48395326
148MP0001501_abnormal_sleep_pattern0.47917406
149MP0003137_abnormal_impulse_conducting0.47679945
150MP0003943_abnormal_hepatobiliary_system0.47648702
151MP0006035_abnormal_mitochondrial_morpho0.47209508
152MP0002234_abnormal_pharynx_morphology0.46317594
153MP0008775_abnormal_heart_ventricle0.46149974
154MP0002282_abnormal_trachea_morphology0.45984947
155MP0005670_abnormal_white_adipose0.44981743
156MP0002102_abnormal_ear_morphology0.44902624
157MP0002163_abnormal_gland_morphology0.44834725
158MP0002067_abnormal_sensory_capabilities0.44165591
159MP0003252_abnormal_bile_duct0.43750383
160MP0003935_abnormal_craniofacial_develop0.43161609
161MP0005367_renal/urinary_system_phenotyp0.41994430
162MP0000516_abnormal_urinary_system0.41994430
163MP0005623_abnormal_meninges_morphology0.41598525
164MP0002697_abnormal_eye_size0.40053498
165MP0002332_abnormal_exercise_endurance0.39883947
166MP0002925_abnormal_cardiovascular_devel0.39674392

Predicted human phenotypes

RankGene SetZ-score
1Aplasia/Hypoplasia affecting the retina (HP:0008061)6.22037023
2Aplasia/Hypoplasia of the macula (HP:0008059)5.98619767
3Aplasia/Hypoplasia of the fovea (HP:0008060)5.63574320
4Hypoplasia of the fovea (HP:0007750)5.63574320
5Ocular albinism (HP:0001107)4.84315467
6Abnormality of the fovea (HP:0000493)4.79575201
7Iris hypopigmentation (HP:0007730)4.60397629
8Ependymoma (HP:0002888)4.59059655
9Abnormality of the labia minora (HP:0012880)4.54505143
10Chromsome breakage (HP:0040012)4.54046730
11Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.50164557
12Birth length less than 3rd percentile (HP:0003561)4.49442561
13Chromosomal breakage induced by crosslinking agents (HP:0003221)4.48084513
14Supernumerary spleens (HP:0009799)4.44236732
15Breast hypoplasia (HP:0003187)4.24624766
16Congenital stationary night blindness (HP:0007642)4.09538935
17Blue irides (HP:0000635)4.02968230
18Patchy hypopigmentation of hair (HP:0011365)3.95458492
19White forelock (HP:0002211)3.94164983
20Medulloblastoma (HP:0002885)3.83181218
21Rhabdomyosarcoma (HP:0002859)3.69593283
22Impulsivity (HP:0100710)3.59980826
23Generalized hypopigmentation (HP:0007513)3.59843645
24Abnormality of the lower motor neuron (HP:0002366)3.54300415
25Absent radius (HP:0003974)3.44497590
26Male infertility (HP:0003251)3.44111449
27Premature ovarian failure (HP:0008209)3.43901626
28Type II lissencephaly (HP:0007260)3.38418165
29Neoplasm of the oral cavity (HP:0100649)3.28698912
30Astrocytoma (HP:0009592)3.28695099
31Abnormality of the astrocytes (HP:0100707)3.28695099
32Selective tooth agenesis (HP:0001592)3.28168582
33Aplasia involving forearm bones (HP:0009822)3.24972251
34Absent forearm bone (HP:0003953)3.24972251
35Patellar aplasia (HP:0006443)3.23179074
36Abnormality of chromosome stability (HP:0003220)3.20395739
37Meckel diverticulum (HP:0002245)3.17918890
38Aplasia/Hypoplasia of the uvula (HP:0010293)3.16917641
39Congenital sensorineural hearing impairment (HP:0008527)3.16553723
40Albinism (HP:0001022)3.14951792
41Agnosia (HP:0010524)3.14677860
42Degeneration of anterior horn cells (HP:0002398)3.13411704
43Abnormality of the anterior horn cell (HP:0006802)3.13411704
44Abnormal auditory evoked potentials (HP:0006958)3.12525604
45Abnormality of the ileum (HP:0001549)3.09021879
46Carpal bone hypoplasia (HP:0001498)3.09004082
47Neoplasm of striated muscle (HP:0009728)3.01861180
48Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.98349823
49Abnormality of the preputium (HP:0100587)2.98150277
50Aplasia/Hypoplasia of the patella (HP:0006498)2.92725408
51Cutaneous melanoma (HP:0012056)2.89926363
52Shawl scrotum (HP:0000049)2.88941733
53Dynein arm defect of respiratory motile cilia (HP:0012255)2.84059182
54Absent/shortened dynein arms (HP:0200106)2.84059182
55Chronic bronchitis (HP:0004469)2.82522236
56Cerebellar dysplasia (HP:0007033)2.80585669
57Aplasia/hypoplasia of the humerus (HP:0006507)2.78948901
58Glioma (HP:0009733)2.78800042
59Hypopigmentation of the fundus (HP:0007894)2.74411641
60Pancreatic cysts (HP:0001737)2.73942742
61Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.72413334
62Colon cancer (HP:0003003)2.71639621
63Acute necrotizing encephalopathy (HP:0006965)2.70383973
64Abnormal respiratory motile cilium physiology (HP:0012261)2.69334545
65Small intestinal stenosis (HP:0012848)2.68624732
66Duodenal stenosis (HP:0100867)2.68624732
67Neoplasm of the adrenal cortex (HP:0100641)2.67087796
68Infertility (HP:0000789)2.66649441
69Abnormality of midbrain morphology (HP:0002418)2.65534914
70Molar tooth sign on MRI (HP:0002419)2.65534914
71Sloping forehead (HP:0000340)2.63940416
72Decreased electroretinogram (ERG) amplitude (HP:0000654)2.63702464
73Absent thumb (HP:0009777)2.62504031
74Short humerus (HP:0005792)2.62088632
75Decreased central vision (HP:0007663)2.59986952
76Facial hemangioma (HP:0000329)2.58174561
77Freckling (HP:0001480)2.57210318
78Increased CSF lactate (HP:0002490)2.55193682
79Pancreatic fibrosis (HP:0100732)2.54579595
80Rib fusion (HP:0000902)2.53259450
81Acute encephalopathy (HP:0006846)2.52043984
82Aplasia/Hypoplasia of the sternum (HP:0006714)2.50874075
83Progressive macrocephaly (HP:0004481)2.50645779
84Abnormality of abdominal situs (HP:0011620)2.49331597
85Abdominal situs inversus (HP:0003363)2.49331597
86Cortical dysplasia (HP:0002539)2.48677242
87Cerebral hypomyelination (HP:0006808)2.46053039
88True hermaphroditism (HP:0010459)2.45923786
89Nephroblastoma (Wilms tumor) (HP:0002667)2.45528702
90Retinal dysplasia (HP:0007973)2.42232049
91Mitochondrial inheritance (HP:0001427)2.38388823
92Ectopic kidney (HP:0000086)2.37106253
93Rhinitis (HP:0012384)2.34979773
94Oral leukoplakia (HP:0002745)2.33879879
95Volvulus (HP:0002580)2.33822681
96Gaze-evoked nystagmus (HP:0000640)2.33292760
97Abolished electroretinogram (ERG) (HP:0000550)2.32391869
98Intestinal atresia (HP:0011100)2.32040132
99Abnormal mitochondria in muscle tissue (HP:0008316)2.31422317
100Astigmatism (HP:0000483)2.30849494
101Tongue fasciculations (HP:0001308)2.30771701
102Abnormal spermatogenesis (HP:0008669)2.29853711
103Horizontal nystagmus (HP:0000666)2.27397277
104Abnormality of the duodenum (HP:0002246)2.26456287
105Amyotrophic lateral sclerosis (HP:0007354)2.24839317
106Secondary amenorrhea (HP:0000869)2.24546646
107Embryonal renal neoplasm (HP:0011794)2.24270907
108Abnormal respiratory epithelium morphology (HP:0012253)2.23832844
109Abnormal respiratory motile cilium morphology (HP:0005938)2.23832844
110Duplicated collecting system (HP:0000081)2.23760390
111Myelodysplasia (HP:0002863)2.22864426
112Nephronophthisis (HP:0000090)2.22492616
113Biliary tract neoplasm (HP:0100574)2.21644713
114Abnormality of the renal cortex (HP:0011035)2.17612045
115Missing ribs (HP:0000921)2.17322799
116Abnormality of the salivary glands (HP:0010286)2.12883066
117Abnormality of DNA repair (HP:0003254)2.12462686
118Median cleft lip (HP:0000161)2.11329806
119Atrophy/Degeneration involving motor neurons (HP:0007373)2.11070480
120Short thumb (HP:0009778)2.10484856
121Abnormal lung lobation (HP:0002101)2.09854674
122Abnormality of the carotid arteries (HP:0005344)2.09113538
123Breast aplasia (HP:0100783)2.08088997
124Horseshoe kidney (HP:0000085)2.07908801
125Upper motor neuron abnormality (HP:0002127)2.07395897
126Cafe-au-lait spot (HP:0000957)2.04954574
127Spinal muscular atrophy (HP:0007269)2.04855978
128Rectovaginal fistula (HP:0000143)2.02848936
129Rectal fistula (HP:0100590)2.02848936
130Basal cell carcinoma (HP:0002671)2.01764382
131Generalized hypopigmentation of hair (HP:0011358)2.01170012
132Sandal gap (HP:0001852)1.98286745
133Papillary thyroid carcinoma (HP:0002895)1.95205315
134Medial flaring of the eyebrow (HP:0010747)1.95090990
135Aplasia/Hypoplasia of the breasts (HP:0010311)1.94593146
136Bone marrow hypocellularity (HP:0005528)1.94462825
137Abnormality of the renal medulla (HP:0100957)1.94413066
138Adrenal hypoplasia (HP:0000835)1.94369156
139Hepatocellular necrosis (HP:0001404)1.90584463
140Large for gestational age (HP:0001520)1.90432258
141Tracheoesophageal fistula (HP:0002575)1.89833960
142Increased hepatocellular lipid droplets (HP:0006565)1.88027254
143Azoospermia (HP:0000027)1.87942312
144Abnormality of cochlea (HP:0000375)1.87652418
145Neoplasm of the adrenal gland (HP:0100631)1.86816471
146Abnormality of the renal collecting system (HP:0004742)1.85129678
147Abnormal ciliary motility (HP:0012262)1.84505790
148Reticulocytopenia (HP:0001896)1.83893661
14911 pairs of ribs (HP:0000878)1.82524382
150Hyperalaninemia (HP:0003348)1.82191320
151Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.82191320
152Abnormality of alanine metabolism (HP:0010916)1.82191320
153Neoplasm of the pancreas (HP:0002894)1.82065796
154Facial cleft (HP:0002006)1.81422112
155Small hand (HP:0200055)1.80069776
156Lipid accumulation in hepatocytes (HP:0006561)1.79689064
157Hypoplasia of the pons (HP:0012110)1.79205710
158Triphalangeal thumb (HP:0001199)1.79158637
159Neoplasm of the colon (HP:0100273)1.78650760
160Lissencephaly (HP:0001339)1.77065411
161Pendular nystagmus (HP:0012043)1.77050545
162Preaxial hand polydactyly (HP:0001177)1.76853431
163Abnormality of pyrimidine metabolism (HP:0004353)1.76601621
164Muscle fibrillation (HP:0010546)1.76020033
165Clubbing of toes (HP:0100760)1.75698898
166Rough bone trabeculation (HP:0100670)1.75485149
167Aplasia/Hypoplasia of the tibia (HP:0005772)1.75038237
168Abnormality of the pons (HP:0007361)1.73520130
169Melanoma (HP:0002861)1.73162678
170Hepatic necrosis (HP:0002605)1.72332861
171Fibular hypoplasia (HP:0003038)1.71373629
172Abnormality of macular pigmentation (HP:0008002)1.70962600
173Congenital hepatic fibrosis (HP:0002612)1.69834438
174Cerebral edema (HP:0002181)1.69633125
175Tubular atrophy (HP:0000092)1.67679706
176Macular degeneration (HP:0000608)1.67638231
177Aplasia/Hypoplasia of the spleen (HP:0010451)1.65656962
178Severe muscular hypotonia (HP:0006829)1.65519907
179Optic disc pallor (HP:0000543)1.64447370
180Short tibia (HP:0005736)1.63181162
181Postaxial foot polydactyly (HP:0001830)1.61587255

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.54759708
2TRIM284.35544493
3CDC74.10460767
4TTK4.09676946
5WEE13.75177333
6BUB13.51429482
7PDK33.41498423
8PDK43.41498423
9CDK123.09719741
10BMPR1B3.05667378
11NEK22.90047293
12PLK42.61355471
13NEK12.43345855
14PLK12.43005481
15PLK22.42126551
16PDK22.37669270
17SIK32.37625902
18EPHA22.29450058
19PNCK2.20184419
20CHEK22.12465895
21MARK32.07258647
22BCR1.93522486
23MAP4K21.92474283
24EIF2AK11.88048973
25STK38L1.84166181
26ACVR1B1.81825074
27MAP3K61.76668150
28SRPK11.76381005
29ADRBK21.72958000
30RPS6KB21.71515913
31CDK71.70217650
32MAP3K31.68240692
33LATS21.67620103
34PTK2B1.66221117
35ERBB31.63846420
36ATR1.61976960
37MAPKAPK31.57776954
38NUAK11.51411373
39OXSR11.51093043
40GRK11.50480668
41STK101.49149909
42CHEK11.48941465
43BRAF1.46973988
44AURKB1.42928053
45AURKA1.36877627
46LATS11.35524287
47PLK31.35176868
48MST1R1.32000307
49WNK41.31965420
50CDK191.31168272
51MAP3K81.30196518
52STK391.28270288
53DYRK31.23507390
54INSRR1.23485723
55EEF2K1.23129578
56ICK1.20956829
57ATM1.17242443
58PASK1.16663067
59TESK21.15265801
60TYRO31.13232638
61CSNK1G21.12779247
62AKT31.12168571
63ERBB41.11549159
64TAOK31.10678831
65CSNK1G11.09428161
66PRKCH1.08716268
67PRKD31.07348507
68TESK11.06223903
69BRSK21.05585738
70FER1.05539890
71VRK11.03077310
72STK31.02974970
73CSNK1G31.01811352
74MST41.01657248
75MAP3K91.00518566
76MELK0.99774984
77CASK0.99481137
78CDK40.97359934
79CDK20.94297302
80TSSK60.93356154
81GRK50.92328389
82MOS0.90974667
83ADRBK10.88560753
84TLK10.82970684
85EIF2AK30.82241721
86CSNK1A1L0.80286753
87MAPK130.79841702
88STK40.77604479
89MUSK0.76322602
90CDK10.74758827
91PAK30.74293013
92DYRK1A0.73524041
93DYRK20.69037599
94PRKCG0.67494490
95BRD40.66639372
96PRKCI0.66444579
97STK380.64761673
98MTOR0.64239556
99GRK60.64164683
100TAF10.63711299
101ALK0.60935730
102PIK3CA0.60385201
103PAK40.60337878
104MAP3K120.58030715
105KSR20.57587255
106PAK10.56251126
107BRSK10.55061611
108FGFR20.54600991
109CSNK1E0.53740881
110PBK0.52711572
111CSNK1D0.52354840
112ZAK0.52285858
113PRKCE0.51731887
114TIE10.51725756
115FGR0.51706842
116STK160.50827147
117CSNK2A20.50769538
118MET0.50302366
119TXK0.47716411
120PIM10.47553427
121CSNK2A10.45738762
122MINK10.45281288
123CDK80.43987593
124CAMKK20.43801092
125GSK3A0.42872140
126BCKDK0.42494037
127FLT30.40987553
128CAMK2A0.38207367
129SCYL20.37915190
130PRKDC0.37216256
131MAP2K10.36566048
132KSR10.35852220
133CDK60.35201100
134MKNK20.35181202
135RAF10.35053395
136PHKG20.33808153
137PHKG10.33808153
138MAP2K60.31556378
139GSK3B0.31400261
140CDK90.30698062
141PINK10.30167918
142MAPK140.29943072
143TGFBR10.28570012
144RPS6KA40.27008877
145MAPK10.25676973
146MAPK100.24566394
147BMPR20.22959957
148CCNB10.22763594
149AKT10.22745531
150MKNK10.20611264
151PAK60.19735944
152PRKAA10.19734111
153WNK30.18408377
154AKT20.15904302
155MAP3K40.15045698
156EIF2AK20.14960380

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034304.62990395
2DNA replication_Homo sapiens_hsa030304.38669019
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.23545180
4RNA transport_Homo sapiens_hsa030133.63392038
5Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.58932965
6Homologous recombination_Homo sapiens_hsa034403.42497828
7Fanconi anemia pathway_Homo sapiens_hsa034603.30846670
8Cell cycle_Homo sapiens_hsa041103.16586227
9Basal transcription factors_Homo sapiens_hsa030223.07786652
10Nucleotide excision repair_Homo sapiens_hsa034202.88302482
11Protein export_Homo sapiens_hsa030602.87243813
12Base excision repair_Homo sapiens_hsa034102.83561600
13One carbon pool by folate_Homo sapiens_hsa006702.78181755
14Spliceosome_Homo sapiens_hsa030402.77842215
15RNA polymerase_Homo sapiens_hsa030202.73830864
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.50754584
17RNA degradation_Homo sapiens_hsa030182.45012430
18Non-homologous end-joining_Homo sapiens_hsa034502.38628521
19Oxidative phosphorylation_Homo sapiens_hsa001902.27337032
20mRNA surveillance pathway_Homo sapiens_hsa030152.21929519
21Proteasome_Homo sapiens_hsa030501.98479089
22Pyrimidine metabolism_Homo sapiens_hsa002401.95130570
23Parkinsons disease_Homo sapiens_hsa050121.92342829
24Vitamin B6 metabolism_Homo sapiens_hsa007501.86665431
25Oocyte meiosis_Homo sapiens_hsa041141.79272963
26p53 signaling pathway_Homo sapiens_hsa041151.77848249
27Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.55992613
28Phototransduction_Homo sapiens_hsa047441.54623646
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.52610298
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.52230926
31Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.50208828
32Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.49015739
33Ribosome_Homo sapiens_hsa030101.44469846
34Butanoate metabolism_Homo sapiens_hsa006501.42216382
35Cysteine and methionine metabolism_Homo sapiens_hsa002701.39405939
36Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.36400026
37Regulation of autophagy_Homo sapiens_hsa041401.36136494
38Fatty acid elongation_Homo sapiens_hsa000621.35970292
39Tyrosine metabolism_Homo sapiens_hsa003501.35540652
40Tryptophan metabolism_Homo sapiens_hsa003801.31564985
41Selenocompound metabolism_Homo sapiens_hsa004501.28613533
42Primary bile acid biosynthesis_Homo sapiens_hsa001201.25959522
43Biosynthesis of amino acids_Homo sapiens_hsa012301.22841979
44Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.18641588
45Purine metabolism_Homo sapiens_hsa002301.18185984
46Alzheimers disease_Homo sapiens_hsa050101.16194465
47Caffeine metabolism_Homo sapiens_hsa002321.15245586
48Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.13780654
49Pentose and glucuronate interconversions_Homo sapiens_hsa000401.12829678
50Nitrogen metabolism_Homo sapiens_hsa009101.12759733
51Collecting duct acid secretion_Homo sapiens_hsa049661.11534722
52Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.10827508
53Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.09946240
54Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.07303580
55Sulfur metabolism_Homo sapiens_hsa009201.05468360
56Chemical carcinogenesis_Homo sapiens_hsa052041.03921095
57Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.03540455
58Maturity onset diabetes of the young_Homo sapiens_hsa049501.01694813
59Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.00295656
60Peroxisome_Homo sapiens_hsa041460.97461753
61SNARE interactions in vesicular transport_Homo sapiens_hsa041300.92878987
62Linoleic acid metabolism_Homo sapiens_hsa005910.92181493
63Systemic lupus erythematosus_Homo sapiens_hsa053220.89621941
64Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.89545723
65Epstein-Barr virus infection_Homo sapiens_hsa051690.89461350
66Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.85608882
67beta-Alanine metabolism_Homo sapiens_hsa004100.84720075
68TGF-beta signaling pathway_Homo sapiens_hsa043500.84588160
69alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.84234969
70Steroid hormone biosynthesis_Homo sapiens_hsa001400.83315618
71Folate biosynthesis_Homo sapiens_hsa007900.83221674
72Viral carcinogenesis_Homo sapiens_hsa052030.82232278
73Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.82038083
74Cyanoamino acid metabolism_Homo sapiens_hsa004600.76254431
75Hippo signaling pathway_Homo sapiens_hsa043900.76212165
76Retinol metabolism_Homo sapiens_hsa008300.76198298
77Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.73509522
78MicroRNAs in cancer_Homo sapiens_hsa052060.72276646
79Pyruvate metabolism_Homo sapiens_hsa006200.70689912
80Pentose phosphate pathway_Homo sapiens_hsa000300.69811190
81Nicotine addiction_Homo sapiens_hsa050330.69192999
82Fatty acid metabolism_Homo sapiens_hsa012120.64824509
83Fructose and mannose metabolism_Homo sapiens_hsa000510.63220817
84Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.60885484
85Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.59872241
86Fatty acid degradation_Homo sapiens_hsa000710.59266607
87Glutathione metabolism_Homo sapiens_hsa004800.58744463
88Dorso-ventral axis formation_Homo sapiens_hsa043200.57971801
89HTLV-I infection_Homo sapiens_hsa051660.57106898
90Thyroid cancer_Homo sapiens_hsa052160.56546809
91Olfactory transduction_Homo sapiens_hsa047400.56208946
92Taste transduction_Homo sapiens_hsa047420.55251791
932-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.54389443
94Carbon metabolism_Homo sapiens_hsa012000.54318749
95Basal cell carcinoma_Homo sapiens_hsa052170.54252637
96Huntingtons disease_Homo sapiens_hsa050160.54129415
97Herpes simplex infection_Homo sapiens_hsa051680.53438885
98Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.53339791
99mTOR signaling pathway_Homo sapiens_hsa041500.51036571
100N-Glycan biosynthesis_Homo sapiens_hsa005100.50910694
101Hedgehog signaling pathway_Homo sapiens_hsa043400.50728784
102Colorectal cancer_Homo sapiens_hsa052100.46814311
103Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.46787727
104ABC transporters_Homo sapiens_hsa020100.45561457
105Notch signaling pathway_Homo sapiens_hsa043300.44588829
106Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.42238908
107Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.40174222
108Drug metabolism - other enzymes_Homo sapiens_hsa009830.38991371
109Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.38376759
110Adherens junction_Homo sapiens_hsa045200.38277309
111Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.35240586
112Tight junction_Homo sapiens_hsa045300.35014760
113Morphine addiction_Homo sapiens_hsa050320.34903014
114Steroid biosynthesis_Homo sapiens_hsa001000.34397370
115Antigen processing and presentation_Homo sapiens_hsa046120.33705482
116Arachidonic acid metabolism_Homo sapiens_hsa005900.33014693
117Transcriptional misregulation in cancer_Homo sapiens_hsa052020.32514884
118Intestinal immune network for IgA production_Homo sapiens_hsa046720.31827524
119Histidine metabolism_Homo sapiens_hsa003400.29639364
120Central carbon metabolism in cancer_Homo sapiens_hsa052300.29212464
121Ether lipid metabolism_Homo sapiens_hsa005650.29027237
122Cardiac muscle contraction_Homo sapiens_hsa042600.28681987
123Arginine and proline metabolism_Homo sapiens_hsa003300.27065314
124Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.26912739
125Glycerophospholipid metabolism_Homo sapiens_hsa005640.26409846
126Small cell lung cancer_Homo sapiens_hsa052220.26022124
127Alcoholism_Homo sapiens_hsa050340.25684859
128Fatty acid biosynthesis_Homo sapiens_hsa000610.24453211
129Wnt signaling pathway_Homo sapiens_hsa043100.23597333
130Lysine degradation_Homo sapiens_hsa003100.23143743
131Glucagon signaling pathway_Homo sapiens_hsa049220.20853860
132Bladder cancer_Homo sapiens_hsa052190.20712853
133Ovarian steroidogenesis_Homo sapiens_hsa049130.20496329
134Pathways in cancer_Homo sapiens_hsa052000.19645487
135Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.18613890
136Metabolic pathways_Homo sapiens_hsa011000.17628750
137Circadian rhythm_Homo sapiens_hsa047100.16075242
138Thyroid hormone signaling pathway_Homo sapiens_hsa049190.15812823
139Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.13635721
140HIF-1 signaling pathway_Homo sapiens_hsa040660.12907079
141Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.11736288
142Longevity regulating pathway - mammal_Homo sapiens_hsa042110.10495374
143Galactose metabolism_Homo sapiens_hsa000520.07900302
144Glycerolipid metabolism_Homo sapiens_hsa005610.04824847
145Other glycan degradation_Homo sapiens_hsa005110.04419573
146Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.04275426
147AMPK signaling pathway_Homo sapiens_hsa041520.02654360
148Sulfur relay system_Homo sapiens_hsa041220.02494218
149Prostate cancer_Homo sapiens_hsa052150.02141995
150Inositol phosphate metabolism_Homo sapiens_hsa005620.01757100
151Propanoate metabolism_Homo sapiens_hsa006400.01465696
152Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.01220218
153Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.01201676

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