TDRD15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)9.33308262
2chromosome organization involved in meiosis (GO:0070192)9.06528519
3male meiosis I (GO:0007141)8.89263480
4synaptonemal complex assembly (GO:0007130)8.25549821
5DNA methylation involved in gamete generation (GO:0043046)8.07498175
6male meiosis (GO:0007140)8.01856350
7synaptonemal complex organization (GO:0070193)7.37591499
8sperm motility (GO:0030317)7.04135960
9meiosis I (GO:0007127)6.88837834
10regulation of meiosis I (GO:0060631)6.56625515
11DNA synthesis involved in DNA repair (GO:0000731)6.56461027
12meiotic nuclear division (GO:0007126)6.46157226
13acrosome reaction (GO:0007340)6.34857059
14fusion of sperm to egg plasma membrane (GO:0007342)6.11455473
15histone H3-K36 demethylation (GO:0070544)6.02806069
16spermatid development (GO:0007286)5.71114101
17histone H3-K9 demethylation (GO:0033169)5.69907600
18meiotic cell cycle process (GO:1903046)5.55116944
19gonadal mesoderm development (GO:0007506)5.23039329
20cilium or flagellum-dependent cell motility (GO:0001539)5.09145399
21sister chromatid cohesion (GO:0007062)4.98251035
22spermatogenesis (GO:0007283)4.94312400
23male gamete generation (GO:0048232)4.93884724
24DNA packaging (GO:0006323)4.86952854
25centriole replication (GO:0007099)4.80955688
26establishment of protein localization to Golgi (GO:0072600)4.79734581
27gamete generation (GO:0007276)4.70349479
28plasma membrane fusion (GO:0045026)4.69293069
29multicellular organism reproduction (GO:0032504)4.66979831
30sperm-egg recognition (GO:0035036)4.66742640
31gene silencing by RNA (GO:0031047)4.51626016
32protein targeting to Golgi (GO:0000042)4.49852851
33fertilization (GO:0009566)4.41023376
34negative regulation of inclusion body assembly (GO:0090084)4.40469216
35sperm capacitation (GO:0048240)4.38996544
36binding of sperm to zona pellucida (GO:0007339)4.34487299
37reciprocal meiotic recombination (GO:0007131)4.27448764
38reciprocal DNA recombination (GO:0035825)4.27448764
39germ cell development (GO:0007281)4.19097927
40genitalia morphogenesis (GO:0035112)4.13720776
41phosphatidylethanolamine biosynthetic process (GO:0006646)4.12866435
42Golgi to endosome transport (GO:0006895)4.11181285
43meiotic chromosome segregation (GO:0045132)4.09100669
44retrograde transport, vesicle recycling within Golgi (GO:0000301)4.07236626
45phosphatidylethanolamine metabolic process (GO:0046337)4.06931392
46centriole assembly (GO:0098534)4.06542287
47regulation of cilium movement (GO:0003352)4.06542130
48chromosome condensation (GO:0030261)4.01737846
49regulation of histone H3-K9 methylation (GO:0051570)4.00399483
50microtubule depolymerization (GO:0007019)3.97883574
51axonemal dynein complex assembly (GO:0070286)3.96149019
52female gamete generation (GO:0007292)3.94640638
53regulation of centriole replication (GO:0046599)3.91321450
54meiotic cell cycle (GO:0051321)3.87192756
55single strand break repair (GO:0000012)3.85975080
56cell-cell recognition (GO:0009988)3.83486752
57reproduction (GO:0000003)3.82808454
58epithelial cilium movement (GO:0003351)3.82615818
59microtubule polymerization or depolymerization (GO:0031109)3.81054159
60cellular process involved in reproduction in multicellular organism (GO:0022412)3.75014296
61resolution of meiotic recombination intermediates (GO:0000712)3.74660251
62multicellular organismal reproductive process (GO:0048609)3.68494282
63positive regulation of Rab GTPase activity (GO:0032851)3.55209694
64regulation of Rab GTPase activity (GO:0032313)3.55209694
65nuclear pore complex assembly (GO:0051292)3.54689868
66DNA alkylation (GO:0006305)3.48832594
67DNA methylation (GO:0006306)3.48832594
68spermatid nucleus differentiation (GO:0007289)3.39920770
69protein polyglutamylation (GO:0018095)3.39429213
70single fertilization (GO:0007338)3.38972615
71epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.38394621
72nucleus organization (GO:0006997)3.37550923
73histone lysine demethylation (GO:0070076)3.36965662
74regulation of microtubule-based movement (GO:0060632)3.35232577
75RNA destabilization (GO:0050779)3.34441779
76regulation of female gonad development (GO:2000194)3.33655318
77calcium ion-dependent exocytosis (GO:0017156)3.31963403
78cilium movement (GO:0003341)3.31500536
79oocyte development (GO:0048599)3.29954071
80mitotic sister chromatid cohesion (GO:0007064)3.28050856
81microtubule severing (GO:0051013)3.26535678
82rRNA methylation (GO:0031167)3.26038587
83histone demethylation (GO:0016577)3.22294040
84seminiferous tubule development (GO:0072520)3.19520717
85gene silencing (GO:0016458)3.18574343
86positive regulation of meiosis (GO:0045836)3.17932011
87positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.17166267
88positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.17166267
89positive regulation of mitotic sister chromatid separation (GO:1901970)3.17166267
90protein K48-linked deubiquitination (GO:0071108)3.11444277
91leukotriene biosynthetic process (GO:0019370)3.11304147
92microtubule nucleation (GO:0007020)3.09217385
93protein localization to Golgi apparatus (GO:0034067)3.05965450
94organic cation transport (GO:0015695)2.99084596
95positive regulation of meiotic cell cycle (GO:0051446)2.97328608
96peptidyl-threonine dephosphorylation (GO:0035970)2.95641375
97protein demethylation (GO:0006482)2.92184433
98protein dealkylation (GO:0008214)2.92184433
99phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.90282497
100synapsis (GO:0007129)11.0298671

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.53199619
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.61030828
3GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.56191102
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.51837033
5CBP_20019798_ChIP-Seq_JUKART_Human2.44264942
6IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.44264942
7TAF15_26573619_Chip-Seq_HEK293_Human2.37261440
8CTBP2_25329375_ChIP-Seq_LNCAP_Human2.27550514
9ER_23166858_ChIP-Seq_MCF-7_Human2.25918820
10FUS_26573619_Chip-Seq_HEK293_Human2.21016995
11PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.20477748
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.18965533
13POU3F2_20337985_ChIP-ChIP_501MEL_Human2.14291775
14VDR_22108803_ChIP-Seq_LS180_Human2.14162513
15IGF1R_20145208_ChIP-Seq_DFB_Human2.13952057
16MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.09888116
17UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human2.04780930
18CTBP1_25329375_ChIP-Seq_LNCAP_Human2.00282625
19POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.98421444
20TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.98421444
21RBPJ_22232070_ChIP-Seq_NCS_Mouse1.97893317
22ZNF274_21170338_ChIP-Seq_K562_Hela1.91796093
23STAT3_23295773_ChIP-Seq_U87_Human1.88907631
24SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.82647697
25ARNT_22903824_ChIP-Seq_MCF-7_Human1.77922237
26FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.75286797
27IRF8_22096565_ChIP-ChIP_GC-B_Human1.75143287
28AR_25329375_ChIP-Seq_VCAP_Human1.72914202
29GBX2_23144817_ChIP-Seq_PC3_Human1.72857078
30MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.72855959
31P300_19829295_ChIP-Seq_ESCs_Human1.67457032
32AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.67324006
33TCF4_23295773_ChIP-Seq_U87_Human1.67168311
34SMAD4_21741376_ChIP-Seq_EPCs_Human1.61719552
35PRDM14_20953172_ChIP-Seq_ESCs_Human1.61601911
36ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.61335551
37CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.58578040
38RUNX2_22187159_ChIP-Seq_PCA_Human1.58378081
39ESR1_20079471_ChIP-ChIP_T-47D_Human1.56263579
40TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.52813143
41EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.49878188
42BCAT_22108803_ChIP-Seq_LS180_Human1.49342897
43EGR1_23403033_ChIP-Seq_LIVER_Mouse1.49178181
44AHR_22903824_ChIP-Seq_MCF-7_Human1.48747427
45SMAD4_21799915_ChIP-Seq_A2780_Human1.47903267
46EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.46798814
47KLF5_20875108_ChIP-Seq_MESCs_Mouse1.45530680
48TOP2B_26459242_ChIP-Seq_MCF-7_Human1.42159441
49GATA3_26560356_Chip-Seq_TH1_Human1.38786399
50WDR5_24793694_ChIP-Seq_LNCAP_Human1.36926084
51SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34122658
52SMRT_27268052_Chip-Seq_Bcells_Human1.33035754
53AR_21572438_ChIP-Seq_LNCaP_Human1.31886649
54FOXH1_21741376_ChIP-Seq_EPCs_Human1.31755291
55VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.30037746
56AUTS2_25519132_ChIP-Seq_293T-REX_Human1.28932528
57FLI1_27457419_Chip-Seq_LIVER_Mouse1.27454164
58SMAD3_21741376_ChIP-Seq_EPCs_Human1.27390579
59RUNX_20019798_ChIP-Seq_JUKART_Human1.24261818
60OCT1_27270436_Chip-Seq_PROSTATE_Human1.23922212
61CDX2_22108803_ChIP-Seq_LS180_Human1.23100916
62ETV1_20927104_ChIP-Seq_GIST48_Human1.22655930
63TCF4_18268006_ChIP-ChIP_LS174T_Human1.21971419
64NR3C1_21868756_ChIP-Seq_MCF10A_Human1.21617437
65NANOG_19829295_ChIP-Seq_ESCs_Human1.17860254
66SOX2_19829295_ChIP-Seq_ESCs_Human1.17860254
67GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.17126224
68CBX2_22325352_ChIP-Seq_293T-Rex_Human1.16324874
69PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.15886105
70TBL1_22424771_ChIP-Seq_293T_Human1.15806501
71NFYB_21822215_ChIP-Seq_K562_Human1.15332291
72ERA_21632823_ChIP-Seq_H3396_Human1.14797234
73PCGF2_27294783_Chip-Seq_ESCs_Mouse1.14518732
74SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.13418053
75FOXA1_21572438_ChIP-Seq_LNCaP_Human1.12767105
76CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.12518553
77TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.12109022
78OCT4_20526341_ChIP-Seq_ESCs_Human1.10573313
79TP63_23658742_ChIP-Seq_EP156T_Human1.10313827
80TCF4_22108803_ChIP-Seq_LS180_Human1.08844161
81MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.07891090
82RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.07290989
83ZNF217_24962896_ChIP-Seq_MCF-7_Human1.07184783
84CEBPB_22108803_ChIP-Seq_LS180_Human1.07061010
85ZFP57_27257070_Chip-Seq_ESCs_Mouse1.06814300
86PHF8_20622853_ChIP-Seq_HELA_Human1.06692994
87RBPJ_21746931_ChIP-Seq_IB4_Human1.06264646
88TP53_22573176_ChIP-Seq_HFKS_Human1.05515688
89RAC3_21632823_ChIP-Seq_H3396_Human1.05420673
90NFE2_27457419_Chip-Seq_LIVER_Mouse1.05191224
91BMI1_23680149_ChIP-Seq_NPCS_Mouse1.04840930
92HOXB7_26014856_ChIP-Seq_BT474_Human1.04720178
93DROSHA_22980978_ChIP-Seq_HELA_Human1.04717211
94HNFA_21074721_ChIP-Seq_CACO-2_Human1.04632512
95FOXA1_27270436_Chip-Seq_PROSTATE_Human1.04447827
96FOXA1_25329375_ChIP-Seq_VCAP_Human1.04447827
97SMAD3_21741376_ChIP-Seq_ESCs_Human1.03944782
98PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.03936091
99NANOG_18555785_Chip-Seq_ESCs_Mouse1.03630279
100CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02657535

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization6.81825014
2MP0008877_abnormal_DNA_methylation6.39165949
3MP0001929_abnormal_gametogenesis4.13746679
4MP0002138_abnormal_hepatobiliary_system4.00801520
5MP0002139_abnormal_hepatobiliary_system3.93840675
6MP0003698_abnormal_male_reproductive3.89838333
7MP0002210_abnormal_sex_determination3.37297777
8MP0000569_abnormal_digit_pigmentation3.00656021
9MP0003718_maternal_effect2.58684619
10MP0008057_abnormal_DNA_replication2.57442233
11MP0001145_abnormal_male_reproductive2.56655636
12MP0000653_abnormal_sex_gland2.48930084
13MP0008995_early_reproductive_senescence2.38704908
14MP0002822_catalepsy2.38507371
15MP0008058_abnormal_DNA_repair2.35752177
16MP0002161_abnormal_fertility/fecundity2.24977962
17MP0002160_abnormal_reproductive_system2.22991596
18MP0003646_muscle_fatigue1.95757629
19MP0009697_abnormal_copulation1.93401857
20MP0003183_abnormal_peptide_metabolism1.87867280
21MP0003252_abnormal_bile_duct1.85392554
22MP0005670_abnormal_white_adipose1.84173031
23MP0000383_abnormal_hair_follicle1.82349995
24MP0005085_abnormal_gallbladder_physiolo1.80478536
25MP0000427_abnormal_hair_cycle1.78485197
26MP0001348_abnormal_lacrimal_gland1.75955456
27MP0005310_abnormal_salivary_gland1.70722235
28MP0003878_abnormal_ear_physiology1.68045379
29MP0005377_hearing/vestibular/ear_phenot1.68045379
30MP0005389_reproductive_system_phenotype1.66239652
31MP0001119_abnormal_female_reproductive1.52719212
32MP0003699_abnormal_female_reproductive1.52524112
33MP0001666_abnormal_nutrient_absorption1.44797638
34MP0002928_abnormal_bile_duct1.40271937
35MP0004381_abnormal_hair_follicle1.34246198
36MP0010678_abnormal_skin_adnexa1.27823872
37MP0000372_irregular_coat_pigmentation1.26642579
38MP0005551_abnormal_eye_electrophysiolog1.25406731
39MP0003868_abnormal_feces_composition1.22920462
40MP0001661_extended_life_span1.21460010
41MP0000015_abnormal_ear_pigmentation1.12430310
42MP0000371_diluted_coat_color1.12058548
43MP0006292_abnormal_olfactory_placode1.11839472
44MP0005379_endocrine/exocrine_gland_phen1.08516445
45MP0005395_other_phenotype1.06597923
46MP0002009_preneoplasia1.02298877
47MP0003693_abnormal_embryo_hatching1.00193818
48MP0010307_abnormal_tumor_latency0.98783723
49MP0005646_abnormal_pituitary_gland0.98685638
50MP0001984_abnormal_olfaction0.94127337
51MP0003879_abnormal_hair_cell0.93416088
52MP0005075_abnormal_melanosome_morpholog0.93170576
53MP0003077_abnormal_cell_cycle0.93043469
54MP0005360_urolithiasis0.90692719
55MP0005174_abnormal_tail_pigmentation0.89970886
56MP0005647_abnormal_sex_gland0.89932306
57MP0003195_calcinosis0.89572680
58MP0005408_hypopigmentation0.89539627
59MP0005365_abnormal_bile_salt0.89218264
60MP0003950_abnormal_plasma_membrane0.86956588
61MP0009115_abnormal_fat_cell0.86258952
62MP0003890_abnormal_embryonic-extraembry0.81801853
63MP0010368_abnormal_lymphatic_system0.80223242
64MP0001919_abnormal_reproductive_system0.77592744
65MP0010329_abnormal_lipoprotein_level0.77316732
66MP0001765_abnormal_ion_homeostasis0.75264292
67MP0002132_abnormal_respiratory_system0.73355331
68MP0008789_abnormal_olfactory_epithelium0.71734307
69MP0002736_abnormal_nociception_after0.71604403
70MP0003786_premature_aging0.70944763
71MP0010094_abnormal_chromosome_stability0.70508662
72MP0005451_abnormal_body_composition0.67483349
73MP0001963_abnormal_hearing_physiology0.66232180
74MP0001968_abnormal_touch/_nociception0.65962906
75MP0001501_abnormal_sleep_pattern0.65363104
76MP0001764_abnormal_homeostasis0.62030123
77MP0004019_abnormal_vitamin_homeostasis0.59644661
78MP0002067_abnormal_sensory_capabilities0.59166974
79MP0001486_abnormal_startle_reflex0.58838504
80MP0001986_abnormal_taste_sensitivity0.58789980
81MP0005253_abnormal_eye_physiology0.58688430
82MP0004036_abnormal_muscle_relaxation0.57480001
83MP0005423_abnormal_somatic_nervous0.56761387
84MP0002282_abnormal_trachea_morphology0.56696706
85MP0001485_abnormal_pinna_reflex0.52918818
86MP0008007_abnormal_cellular_replicative0.52549608
87MP0001800_abnormal_humoral_immune0.52103975
88MP0005499_abnormal_olfactory_system0.47837513
89MP0005394_taste/olfaction_phenotype0.47837513
90MP0003787_abnormal_imprinting0.47714811
91MP0002735_abnormal_chemical_nociception0.47410938
92MP0003763_abnormal_thymus_physiology0.47344271
93MP0002136_abnormal_kidney_physiology0.45847419
94MP0003121_genomic_imprinting0.44872340
95MP0004742_abnormal_vestibular_system0.44715053
96MP0005332_abnormal_amino_acid0.43776206
97MP0001835_abnormal_antigen_presentation0.43498143
98MP0002229_neurodegeneration0.43476316
99MP0008004_abnormal_stomach_pH0.42312659
100MP0004484_altered_response_of0.42088390

Predicted human phenotypes

RankGene SetZ-score
1Tubulointerstitial nephritis (HP:0001970)5.44875914
2Spontaneous abortion (HP:0005268)5.09796817
3Azoospermia (HP:0000027)5.04738928
4Abnormal spermatogenesis (HP:0008669)4.63894363
5Absent/shortened dynein arms (HP:0200106)4.35100228
6Dynein arm defect of respiratory motile cilia (HP:0012255)4.35100228
7Severe visual impairment (HP:0001141)4.18946735
8Chronic hepatic failure (HP:0100626)4.07783491
9Hyperkalemia (HP:0002153)4.01926568
10Volvulus (HP:0002580)3.82882728
11Truncal obesity (HP:0001956)3.69415964
12Oligodactyly (hands) (HP:0001180)3.69254408
13Osteomalacia (HP:0002749)3.52453287
14Abnormal ciliary motility (HP:0012262)3.45187365
15Gonadotropin excess (HP:0000837)3.37367105
16Attenuation of retinal blood vessels (HP:0007843)3.34230454
17Degeneration of the lateral corticospinal tracts (HP:0002314)3.29405718
18Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.29405718
19Horizontal nystagmus (HP:0000666)3.23034647
20Abnormal respiratory motile cilium physiology (HP:0012261)3.16487263
21Infertility (HP:0000789)3.14749670
22Bony spicule pigmentary retinopathy (HP:0007737)3.08267548
23Nephronophthisis (HP:0000090)2.98293089
24Abnormal respiratory motile cilium morphology (HP:0005938)2.97940015
25Abnormal respiratory epithelium morphology (HP:0012253)2.97940015
26Abnormality of the renal medulla (HP:0100957)2.93217226
27Supernumerary spleens (HP:0009799)2.92562428
28Chronic sinusitis (HP:0011109)2.92125941
29Tubulointerstitial abnormality (HP:0001969)2.88505601
30Resting tremor (HP:0002322)2.78097500
31Cone-rod dystrophy (HP:0000548)2.75901364
32Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.75773939
33Bile duct proliferation (HP:0001408)2.73133685
34Abnormal biliary tract physiology (HP:0012439)2.73133685
35Impulsivity (HP:0100710)2.61031277
36Fair hair (HP:0002286)2.59236183
37Recurrent bronchitis (HP:0002837)2.58250632
38Abnormal sex determination (HP:0012244)2.58006858
39Sex reversal (HP:0012245)2.58006858
40Aplasia/Hypoplasia of the earlobes (HP:0009906)2.56511431
41Abnormality of macular pigmentation (HP:0008002)2.54080155
42Abnormality of the corticospinal tract (HP:0002492)2.53756939
43Amyotrophic lateral sclerosis (HP:0007354)2.53117910
44Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.52143446
45Menstrual irregularities (HP:0000858)2.45436892
46Male infertility (HP:0003251)2.44475441
47Intrahepatic cholestasis (HP:0001406)2.41033773
48Hypoplasia of the thymus (HP:0000778)2.37709715
49Scotoma (HP:0000575)2.25255467
50Progressive cerebellar ataxia (HP:0002073)2.20729279
51Stage 5 chronic kidney disease (HP:0003774)2.19519573
52Gonadal dysgenesis (HP:0000133)2.17105183
53Potter facies (HP:0002009)2.16487473
54Facial shape deformation (HP:0011334)2.16487473
55Gaze-evoked nystagmus (HP:0000640)2.11344296
56Tubular atrophy (HP:0000092)2.10035512
57Abnormality of potassium homeostasis (HP:0011042)2.09974597
58Bell-shaped thorax (HP:0001591)2.09508303
59Abnormality of the renal cortex (HP:0011035)2.09424332
60Hypophosphatemic rickets (HP:0004912)2.08697473
61Oligodactyly (HP:0012165)2.02361693
62Macular degeneration (HP:0000608)2.00124321
63Bronchitis (HP:0012387)1.99533754
64Postural instability (HP:0002172)1.98309082
65Capillary hemangiomas (HP:0005306)1.98129810
66Recurrent pneumonia (HP:0006532)1.96766791
67Genetic anticipation (HP:0003743)1.96298586
68Facial hemangioma (HP:0000329)1.95579415
69Abnormality of DNA repair (HP:0003254)1.94944231
70Abnormality of the lower motor neuron (HP:0002366)1.91055358
71Abnormal rod and cone electroretinograms (HP:0008323)1.89893788
72Widely spaced teeth (HP:0000687)1.89414315
73Pancreatic fibrosis (HP:0100732)1.89328919
74Portal hypertension (HP:0001409)1.88900521
75Impaired vibration sensation in the lower limbs (HP:0002166)1.87477280
76Agammaglobulinemia (HP:0004432)1.87112086
77Abnormality of monocarboxylic acid metabolism (HP:0010996)1.85848064
78Generalized aminoaciduria (HP:0002909)1.84500829
79Ectopic kidney (HP:0000086)1.82538040
80Impaired vibratory sensation (HP:0002495)1.80970218
81Rhinitis (HP:0012384)1.79236974
8211 pairs of ribs (HP:0000878)1.77807320
83Upper motor neuron abnormality (HP:0002127)1.77571027
84Bronchiectasis (HP:0002110)1.77466874
85Sandal gap (HP:0001852)1.77354320
86Proximal tubulopathy (HP:0000114)1.75738585
87Decreased central vision (HP:0007663)1.75166094
88Generalized hypopigmentation of hair (HP:0011358)1.74058530
89Sloping forehead (HP:0000340)1.74009333
90Abnormality of chloride homeostasis (HP:0011422)1.73219701
91Abnormality of the hepatic vasculature (HP:0006707)1.71704485
92Rhabdomyosarcoma (HP:0002859)1.70996523
93Enlarged epiphyses (HP:0010580)1.70727625
94Rickets (HP:0002748)1.69684300
95Cystic liver disease (HP:0006706)1.68216288
96Clitoromegaly (HP:0000057)1.68200413
97Conjugated hyperbilirubinemia (HP:0002908)1.66285372
98Pancreatic cysts (HP:0001737)1.65279107
99Male pseudohermaphroditism (HP:0000037)1.65197699
100Abnormality of chromosome stability (HP:0003220)1.64517523

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK5.19435035
2PNCK5.10334168
3PLK44.21825268
4FRK3.07843406
5STK38L2.99196735
6RIPK42.55024674
7MET2.40134327
8CAMK1G2.34938130
9PIK3CG2.30412214
10AKT32.29419212
11STK382.22329769
12NEK62.18935576
13PLK22.17347542
14MAP3K132.17043654
15BMPR22.09308681
16CDK191.82236485
17MAP3K91.78816980
18BRD41.68033074
19FER1.56986614
20ACVR1B1.53813144
21PTK2B1.53503364
22INSRR1.50674403
23NEK91.39313368
24PINK11.35588685
25BRAF1.32134930
26PDK11.28466890
27PAK31.19853074
28BRSK21.19001983
29DDR21.17411065
30MST1R1.14645863
31OXSR11.13155110
32PDPK11.12356187
33PRKCI1.12280817
34SGK21.08136438
35TYRO31.06002358
36CSF1R0.99357381
37MELK0.95301153
38DYRK1B0.87907441
39FGFR30.83863163
40MAP3K10.81405490
41MAP3K20.81394854
42KSR20.79754624
43CDK120.79746431
44MAP2K10.79376041
45MAP2K20.78392199
46CHEK10.76908930
47SGK2230.76246931
48SGK4940.76246931
49PDK20.74689750
50NLK0.72939374
51MST40.72217644
52CDK30.70868772
53SYK0.68330314
54CDK70.66896767
55RPS6KB10.66188703
56WNK10.65418351
57SGK10.65033043
58TAOK30.63100014
59BMPR1B0.62917214
60CAMK10.62805137
61SGK30.61379553
62TESK10.61331191
63PRKG10.56018924
64FGR0.53475760
65MAP3K40.52531446
66NTRK30.51620411
67FGFR10.51362386
68ARAF0.50616826
69BRSK10.50331965
70CDK90.49673953
71MAP3K70.49028872
72CDK20.48745086
73MARK20.48620107
74EGFR0.48301472
75GRK60.45520565
76MOS0.44784107
77MARK30.44061508
78RET0.43835351
79MAPK110.43572703
80CHUK0.43124660
81PKN10.42277657
82STK390.41451903
83TNK20.41030031
84MAPK10.40025211
85CDK10.39772078
86PAK10.39757757
87PRKD30.39740205
88CDK40.39094511
89GSK3B0.38650512
90WNK40.38593855
91BMX0.36798230
92ATM0.36276226
93PDGFRB0.35419160
94PLK10.35005386
95EIF2AK30.34642181
96PRKCZ0.33580504
97MAPK150.33061532
98DYRK1A0.33022370
99PRKG20.31679565
100GRK10.30922650

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000613.51393016
2ABC transporters_Homo sapiens_hsa020102.50012615
3B cell receptor signaling pathway_Homo sapiens_hsa046622.32549357
4Olfactory transduction_Homo sapiens_hsa047402.20172420
5Butanoate metabolism_Homo sapiens_hsa006502.18928806
6Selenocompound metabolism_Homo sapiens_hsa004502.16733714
7Dorso-ventral axis formation_Homo sapiens_hsa043202.14035427
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.80377662
9Fanconi anemia pathway_Homo sapiens_hsa034601.71266186
10Fatty acid degradation_Homo sapiens_hsa000711.70877501
11Mismatch repair_Homo sapiens_hsa034301.65307590
12Caffeine metabolism_Homo sapiens_hsa002321.65193041
13Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.64815070
14Homologous recombination_Homo sapiens_hsa034401.64571136
15Phenylalanine metabolism_Homo sapiens_hsa003601.60542972
16Retinol metabolism_Homo sapiens_hsa008301.48572114
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.47731798
18Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.45687203
19Oocyte meiosis_Homo sapiens_hsa041141.45537495
20Basal transcription factors_Homo sapiens_hsa030221.45484713
21Complement and coagulation cascades_Homo sapiens_hsa046101.43775723
22Inositol phosphate metabolism_Homo sapiens_hsa005621.42706501
23Primary bile acid biosynthesis_Homo sapiens_hsa001201.39965907
24RNA transport_Homo sapiens_hsa030131.39562866
25Phosphatidylinositol signaling system_Homo sapiens_hsa040701.39385029
26Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.29538373
27Circadian rhythm_Homo sapiens_hsa047101.25761872
28Staphylococcus aureus infection_Homo sapiens_hsa051501.25543519
29Cell cycle_Homo sapiens_hsa041101.22997967
30Taste transduction_Homo sapiens_hsa047421.21366291
31Glycerophospholipid metabolism_Homo sapiens_hsa005641.21171554
32Steroid hormone biosynthesis_Homo sapiens_hsa001401.20018031
33mTOR signaling pathway_Homo sapiens_hsa041501.18218966
34beta-Alanine metabolism_Homo sapiens_hsa004101.16533126
35Linoleic acid metabolism_Homo sapiens_hsa005911.13162676
36Propanoate metabolism_Homo sapiens_hsa006401.11428603
37Non-homologous end-joining_Homo sapiens_hsa034501.07557457
38Type II diabetes mellitus_Homo sapiens_hsa049301.05776796
39Chemical carcinogenesis_Homo sapiens_hsa052041.04089427
40Bile secretion_Homo sapiens_hsa049761.03415252
41N-Glycan biosynthesis_Homo sapiens_hsa005101.02640086
42Choline metabolism in cancer_Homo sapiens_hsa052310.94500346
43Fatty acid metabolism_Homo sapiens_hsa012120.93890686
44Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.93728272
45Histidine metabolism_Homo sapiens_hsa003400.92630583
46Non-small cell lung cancer_Homo sapiens_hsa052230.84902120
47Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.82183492
48Cyanoamino acid metabolism_Homo sapiens_hsa004600.81178708
49Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.76195327
50Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.76135544
51Phototransduction_Homo sapiens_hsa047440.75555658
52Tyrosine metabolism_Homo sapiens_hsa003500.74813869
53Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.72355769
54ErbB signaling pathway_Homo sapiens_hsa040120.71869706
55Intestinal immune network for IgA production_Homo sapiens_hsa046720.68865653
56Regulation of autophagy_Homo sapiens_hsa041400.67120293
57Primary immunodeficiency_Homo sapiens_hsa053400.66375457
58Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.65319013
59Nicotine addiction_Homo sapiens_hsa050330.65197800
60RNA degradation_Homo sapiens_hsa030180.64623585
61Serotonergic synapse_Homo sapiens_hsa047260.63189077
62Calcium signaling pathway_Homo sapiens_hsa040200.62914352
63Lysine degradation_Homo sapiens_hsa003100.62058151
64Allograft rejection_Homo sapiens_hsa053300.61938369
65mRNA surveillance pathway_Homo sapiens_hsa030150.58434881
66Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56528885
67Prostate cancer_Homo sapiens_hsa052150.56462225
68PPAR signaling pathway_Homo sapiens_hsa033200.54988877
69Nucleotide excision repair_Homo sapiens_hsa034200.54357653
70T cell receptor signaling pathway_Homo sapiens_hsa046600.54242342
71VEGF signaling pathway_Homo sapiens_hsa043700.53500524
72Glycerolipid metabolism_Homo sapiens_hsa005610.53161839
73Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.51358569
74Tryptophan metabolism_Homo sapiens_hsa003800.51311055
75Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.51253080
76Prolactin signaling pathway_Homo sapiens_hsa049170.51005669
77Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.49803812
78Sulfur relay system_Homo sapiens_hsa041220.48489619
79Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.46254010
80MAPK signaling pathway_Homo sapiens_hsa040100.45991323
81Insulin resistance_Homo sapiens_hsa049310.45811992
82Pentose and glucuronate interconversions_Homo sapiens_hsa000400.45073694
83Graft-versus-host disease_Homo sapiens_hsa053320.42338733
84Drug metabolism - other enzymes_Homo sapiens_hsa009830.41860360
85Small cell lung cancer_Homo sapiens_hsa052220.40894756
86Adipocytokine signaling pathway_Homo sapiens_hsa049200.39991111
87SNARE interactions in vesicular transport_Homo sapiens_hsa041300.39456947
88Arachidonic acid metabolism_Homo sapiens_hsa005900.39187039
89Vitamin digestion and absorption_Homo sapiens_hsa049770.38495955
90Carbohydrate digestion and absorption_Homo sapiens_hsa049730.38317344
91Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.38244677
92Maturity onset diabetes of the young_Homo sapiens_hsa049500.37114795
93Leishmaniasis_Homo sapiens_hsa051400.36217210
94Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.36186219
95Arginine biosynthesis_Homo sapiens_hsa002200.35725802
96alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.35672959
97Estrogen signaling pathway_Homo sapiens_hsa049150.35520382
98Influenza A_Homo sapiens_hsa051640.35202513
99Base excision repair_Homo sapiens_hsa034100.35200152
100Long-term depression_Homo sapiens_hsa047300.35062180

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