TDRD3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1melanin biosynthetic process (GO:0042438)6.03511601
2secondary metabolite biosynthetic process (GO:0044550)5.96202211
3melanin metabolic process (GO:0006582)5.68257316
4regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.59997143
5mitotic sister chromatid cohesion (GO:0007064)4.94821838
6sarcoplasmic reticulum calcium ion transport (GO:0070296)4.93841782
7monoubiquitinated protein deubiquitination (GO:0035520)4.87760697
8piRNA metabolic process (GO:0034587)4.47057064
9melanocyte differentiation (GO:0030318)4.36270220
10pigment cell differentiation (GO:0050931)4.25952349
11mitotic chromosome condensation (GO:0007076)4.15408550
12regulation of skeletal muscle contraction (GO:0014819)4.01921703
13regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.94239146
14regulation of relaxation of muscle (GO:1901077)3.91677797
15positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.85461684
16keratan sulfate catabolic process (GO:0042340)3.82622298
17interkinetic nuclear migration (GO:0022027)3.79421636
18prenylation (GO:0097354)3.76628667
19protein prenylation (GO:0018342)3.76628667
20epithelial cilium movement (GO:0003351)3.70826999
21regulation of pigment cell differentiation (GO:0050932)3.67440408
22cilium movement (GO:0003341)3.67288893
23intraciliary transport (GO:0042073)3.66131043
24protein localization to cilium (GO:0061512)3.59813037
25neuroepithelial cell differentiation (GO:0060563)3.58577252
26actin-myosin filament sliding (GO:0033275)3.56193656
27muscle filament sliding (GO:0030049)3.56193656
28platelet dense granule organization (GO:0060155)3.50516734
29pore complex assembly (GO:0046931)3.36748108
30regulation of centriole replication (GO:0046599)3.36300928
31DNA methylation involved in gamete generation (GO:0043046)3.33582872
32establishment of protein localization to Golgi (GO:0072600)3.31482242
33protein polyglutamylation (GO:0018095)3.27874697
34regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.25609340
35centriole replication (GO:0007099)3.25355333
36nuclear pore complex assembly (GO:0051292)3.24719819
37cilium or flagellum-dependent cell motility (GO:0001539)3.23420684
38negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.21752296
39negative regulation of keratinocyte proliferation (GO:0010839)3.21125695
40myofibril assembly (GO:0030239)3.18271485
41protein K11-linked deubiquitination (GO:0035871)3.17340966
42heart contraction (GO:0060047)3.16431235
43heart process (GO:0003015)3.16431235
44regulation of glucocorticoid metabolic process (GO:0031943)3.15116195
45genitalia morphogenesis (GO:0035112)3.14661489
46male meiosis I (GO:0007141)3.13499568
47axoneme assembly (GO:0035082)3.12971400
48sister chromatid cohesion (GO:0007062)3.10872624
49response to inactivity (GO:0014854)3.09905815
50histone H3-K9 demethylation (GO:0033169)3.08519213
51actin-mediated cell contraction (GO:0070252)3.07704953
52regulation of meiosis I (GO:0060631)3.07576536
53regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.03772368
54regulation of hexokinase activity (GO:1903299)3.01787666
55regulation of glucokinase activity (GO:0033131)3.01787666
56protein targeting to Golgi (GO:0000042)3.00562526
57glucocorticoid receptor signaling pathway (GO:0042921)3.00499607
58cilium organization (GO:0044782)2.99372425
59regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.97821945
60meiotic chromosome segregation (GO:0045132)2.96374858
61cAMP catabolic process (GO:0006198)2.95892965
62coronary vasculature morphogenesis (GO:0060977)2.95704931
63attachment of spindle microtubules to kinetochore (GO:0008608)2.95082707
64cilium assembly (GO:0042384)2.95005284
65synapsis (GO:0007129)2.94607584
66phenol-containing compound biosynthetic process (GO:0046189)2.90138155
67behavioral response to nicotine (GO:0035095)2.86960105
68retrograde transport, vesicle recycling within Golgi (GO:0000301)2.86619468
69metaphase plate congression (GO:0051310)2.82669777
70regulation of sarcomere organization (GO:0060297)2.82219433
71male meiosis (GO:0007140)2.80632423
72tyrosine metabolic process (GO:0006570)2.80228945
73protein targeting to lysosome (GO:0006622)2.80011122
74establishment of protein localization to vacuole (GO:0072666)2.80011122
75protein targeting to vacuole (GO:0006623)2.80011122
76negative regulation of mast cell activation (GO:0033004)2.79316994
77snRNA processing (GO:0016180)2.78881784
78negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.78358479
79embryonic viscerocranium morphogenesis (GO:0048703)2.77522266
80negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.76920915
81regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.75124438
82negative regulation of cytosolic calcium ion concentration (GO:0051481)2.74580279
83cellular component assembly involved in morphogenesis (GO:0010927)2.74463222
84photoreceptor cell maintenance (GO:0045494)2.74062168
85negative regulation of potassium ion transmembrane transport (GO:1901380)2.71646982
86definitive hemopoiesis (GO:0060216)2.70100506
87nucleus localization (GO:0051647)2.69811804
88regulation of transforming growth factor beta2 production (GO:0032909)2.69646405
89retinal rod cell development (GO:0046548)2.68694116
90glomerular filtration (GO:0003094)2.68663844
91negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.68089152
92prostate gland growth (GO:0060736)2.67608821
93cyclic nucleotide catabolic process (GO:0009214)2.67266785
94cardiac myofibril assembly (GO:0055003)2.66425086
95snRNA metabolic process (GO:0016073)2.65176558
96negative regulation of neurotransmitter transport (GO:0051589)2.64477331
97mismatch repair (GO:0006298)2.62754023
98left/right axis specification (GO:0070986)2.61021404
99positive regulation of receptor biosynthetic process (GO:0010870)2.60177848
100microtubule anchoring (GO:0034453)2.59471821
101regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.58600579
102negative regulation of hormone biosynthetic process (GO:0032353)2.57994502
103negative regulation of hormone metabolic process (GO:0032351)2.57994502
104cilium morphogenesis (GO:0060271)2.56437459
105CENP-A containing nucleosome assembly (GO:0034080)2.56252073
106positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.54901766
107positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.53957459
108negative regulation of cell cycle G2/M phase transition (GO:1902750)2.53742815
109nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.53608194
110histone H2A monoubiquitination (GO:0035518)2.53273486
111intracellular lipid transport (GO:0032365)2.53100907
112adult heart development (GO:0007512)2.53067233
113regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.52664340
114nuclear pore organization (GO:0006999)2.52614324
115microtubule depolymerization (GO:0007019)2.50586967
116response to caffeine (GO:0031000)2.50153619
117gland morphogenesis (GO:0022612)2.49615666
118protein K63-linked deubiquitination (GO:0070536)2.49526808
119regulation of centrosome cycle (GO:0046605)2.49437091
120motile cilium assembly (GO:0044458)2.49195150
121spindle checkpoint (GO:0031577)2.48937800
122positive regulation of cell cycle G2/M phase transition (GO:1902751)2.47938986
123positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.47938986
124regulation of cell cycle G2/M phase transition (GO:1902749)2.47539521
125regulation of retinoic acid receptor signaling pathway (GO:0048385)2.46930819
126regulation of establishment of planar polarity (GO:0090175)2.44982009
127renal filtration (GO:0097205)2.44723849
128lung lobe morphogenesis (GO:0060463)2.44158395
129resolution of meiotic recombination intermediates (GO:0000712)2.43819733
130positive regulation of osteoclast differentiation (GO:0045672)2.41691765
131DNA packaging (GO:0006323)2.41678136
132regulation of actin filament-based movement (GO:1903115)2.41629582
133mitotic metaphase plate congression (GO:0007080)2.41471722
134regulation of cell communication by electrical coupling (GO:0010649)2.41357313
135regulation of steroid hormone biosynthetic process (GO:0090030)2.41160892
136neural tube formation (GO:0001841)2.41086042
137regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.40547584
138sister chromatid segregation (GO:0000819)2.40029098
139cardiac muscle cell proliferation (GO:0060038)2.39991627
140regulation of sister chromatid cohesion (GO:0007063)2.39874097
141regulation of DNA damage checkpoint (GO:2000001)2.39384518
142epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.38999173
143DNA damage induced protein phosphorylation (GO:0006975)2.38851725
144embryonic body morphogenesis (GO:0010172)2.38631483
145spindle assembly checkpoint (GO:0071173)2.38573164
146limb development (GO:0060173)2.38114162
147appendage development (GO:0048736)2.38114162
148regulation of G2/M transition of mitotic cell cycle (GO:0010389)2.37865300
149paraxial mesoderm development (GO:0048339)2.37773617
150response to pheromone (GO:0019236)2.37692398
151negative regulation of DNA repair (GO:0045738)2.37441889
152chromosome condensation (GO:0030261)2.37218146
153non-canonical Wnt signaling pathway (GO:0035567)2.36985837
154regulation of mitotic spindle checkpoint (GO:1903504)2.36348693
155regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.36348693
156detection of light stimulus involved in visual perception (GO:0050908)2.36222911
157detection of light stimulus involved in sensory perception (GO:0050962)2.36222911
158negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.35626274
159negative regulation of sister chromatid segregation (GO:0033046)2.35626274
160negative regulation of mitotic sister chromatid separation (GO:2000816)2.35626274
161negative regulation of mitotic sister chromatid segregation (GO:0033048)2.35626274
162DNA damage response, signal transduction resulting in transcription (GO:0042772)2.35573227
163retina layer formation (GO:0010842)2.35446414
164chromatin remodeling at centromere (GO:0031055)2.35334696
165regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.35184401
166actin filament-based movement (GO:0030048)2.35171197
167regulation of DNA endoreduplication (GO:0032875)2.34667144
168microtubule nucleation (GO:0007020)2.34645528
169oligosaccharide catabolic process (GO:0009313)2.34379416
170mitotic spindle assembly checkpoint (GO:0007094)2.34326709
171nonmotile primary cilium assembly (GO:0035058)2.34054387
172DNA unwinding involved in DNA replication (GO:0006268)2.33811151
173trivalent inorganic anion homeostasis (GO:0072506)2.33453573
174DNA replication-independent nucleosome assembly (GO:0006336)2.33223717
175DNA replication-independent nucleosome organization (GO:0034724)2.33223717
176mesenchymal to epithelial transition (GO:0060231)2.33098729
177histone exchange (GO:0043486)2.32341852
178centrosome localization (GO:0051642)2.32273543
179protein localization to chromosome, centromeric region (GO:0071459)2.31791621
180type B pancreatic cell development (GO:0003323)2.31697377
181mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.30834614
182negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.29547654
183microtubule polymerization or depolymerization (GO:0031109)2.29547271
184regulation of centrosome duplication (GO:0010824)2.29535550
185embryonic digit morphogenesis (GO:0042733)2.29532579
186positive regulation of DNA-dependent DNA replication (GO:2000105)2.28556011
187reciprocal meiotic recombination (GO:0007131)2.28418314
188reciprocal DNA recombination (GO:0035825)2.28418314
189kinetochore organization (GO:0051383)2.28292755
190regulation of chromosome segregation (GO:0051983)2.27953088
191negative regulation of chromosome segregation (GO:0051985)2.27601674
192regulation of spindle organization (GO:0090224)2.26913305

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RBPJ_22232070_ChIP-Seq_NCS_Mouse7.88497538
2E2F7_22180533_ChIP-Seq_HELA_Human5.72496087
3SALL1_21062744_ChIP-ChIP_HESCs_Human4.33398171
4STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.83421506
5EZH2_22144423_ChIP-Seq_EOC_Human3.17882757
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.11063642
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.10257522
8GBX2_23144817_ChIP-Seq_PC3_Human3.10198193
9CEBPD_23245923_ChIP-Seq_MEFs_Mouse3.04769720
10BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.67203794
11* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.66068405
12TP63_19390658_ChIP-ChIP_HaCaT_Human2.59987037
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.58669554
14* E2F4_17652178_ChIP-ChIP_JURKAT_Human2.54494720
15KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.51133480
16AR_21909140_ChIP-Seq_LNCAP_Human2.42863504
17FUS_26573619_Chip-Seq_HEK293_Human2.42311811
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.37991324
19VDR_22108803_ChIP-Seq_LS180_Human2.27059860
20EP300_21415370_ChIP-Seq_HL-1_Mouse2.13709605
21PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.13348824
22EWS_26573619_Chip-Seq_HEK293_Human2.09365823
23TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.09290647
24PCGF2_27294783_Chip-Seq_ESCs_Mouse2.06711446
25RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.01317394
26P300_19829295_ChIP-Seq_ESCs_Human1.96762257
27AR_21572438_ChIP-Seq_LNCaP_Human1.95200121
28POU3F2_20337985_ChIP-ChIP_501MEL_Human1.90787349
29HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.89989280
30SUZ12_27294783_Chip-Seq_NPCs_Mouse1.87020054
31MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.81556339
32EZH2_27294783_Chip-Seq_NPCs_Mouse1.77222428
33ESR1_20079471_ChIP-ChIP_T-47D_Human1.74246244
34CDX2_19796622_ChIP-Seq_MESCs_Mouse1.73007955
35BCAT_22108803_ChIP-Seq_LS180_Human1.70231721
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.69352771
37PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.68326917
38ZNF217_24962896_ChIP-Seq_MCF-7_Human1.67252826
39NFE2_27457419_Chip-Seq_LIVER_Mouse1.66690642
40WT1_19549856_ChIP-ChIP_CCG9911_Human1.65510329
41TCF4_23295773_ChIP-Seq_U87_Human1.64841203
42UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.64182451
43EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.62641154
44AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.62313501
45FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.61559112
46NANOG_18555785_Chip-Seq_ESCs_Mouse1.61509710
47ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.61119695
48YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.58730951
49SMAD3_21741376_ChIP-Seq_EPCs_Human1.57868544
50MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.56851389
51PCGF2_27294783_Chip-Seq_NPCs_Mouse1.56308972
52* CBP_20019798_ChIP-Seq_JUKART_Human1.55551893
53* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.55551893
54CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.52018096
55CTBP1_25329375_ChIP-Seq_LNCAP_Human1.49557720
56E2F1_18555785_Chip-Seq_ESCs_Mouse1.49551585
57* BRD4_25478319_ChIP-Seq_HGPS_Human1.49306419
58E2F1_21310950_ChIP-Seq_MCF-7_Human1.48781222
59PADI4_21655091_ChIP-ChIP_MCF-7_Human1.47688245
60EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.47526216
61CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.44603094
62* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.43485990
63POU5F1_16153702_ChIP-ChIP_HESCs_Human1.41604851
64P53_22387025_ChIP-Seq_ESCs_Mouse1.41404465
65SUZ12_18555785_Chip-Seq_ESCs_Mouse1.39544642
66ER_23166858_ChIP-Seq_MCF-7_Human1.39258727
67ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.37077399
68GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.33677417
69EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.32672675
70CRX_20693478_ChIP-Seq_RETINA_Mouse1.30663997
71CMYC_18555785_Chip-Seq_ESCs_Mouse1.29089381
72FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.27781118
73GATA4_21415370_ChIP-Seq_HL-1_Mouse1.26796258
74STAT3_18555785_Chip-Seq_ESCs_Mouse1.26796061
75* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.26748524
76EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.26106613
77IGF1R_20145208_ChIP-Seq_DFB_Human1.26044031
78P300_18555785_Chip-Seq_ESCs_Mouse1.25985870
79TCF4_22108803_ChIP-Seq_LS180_Human1.25893121
80RUNX2_22187159_ChIP-Seq_PCA_Human1.25325733
81NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.25165559
82* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25129893
83DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.23090381
84SMAD_19615063_ChIP-ChIP_OVARY_Human1.21537796
85* PIAS1_25552417_ChIP-Seq_VCAP_Human1.21210766
86* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.20674833
87* TAL1_26923725_Chip-Seq_HPCs_Mouse1.20166430
88ISL1_27105846_Chip-Seq_CPCs_Mouse1.19442295
89TP53_16413492_ChIP-PET_HCT116_Human1.19441186
90SOX2_21211035_ChIP-Seq_LN229_Gbm1.19329462
91DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.19191070
92EGR1_19374776_ChIP-ChIP_THP-1_Human1.18590080
93OCT4_21477851_ChIP-Seq_ESCs_Mouse1.18530333
94TBX3_20139965_ChIP-Seq_ESCs_Mouse1.16785619
95TAF15_26573619_Chip-Seq_HEK293_Human1.16765869
96SOX2_19829295_ChIP-Seq_ESCs_Human1.16354854
97NANOG_19829295_ChIP-Seq_ESCs_Human1.16354854
98* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.15866584
99CTBP2_25329375_ChIP-Seq_LNCAP_Human1.15827647
100NMYC_18555785_Chip-Seq_ESCs_Mouse1.15437962
101SMAD4_21741376_ChIP-Seq_EPCs_Human1.15412699
102TBX3_20139965_ChIP-Seq_MESCs_Mouse1.15271807
103OCT4_18555785_Chip-Seq_ESCs_Mouse1.15149211
104SOX2_18555785_Chip-Seq_ESCs_Mouse1.15138563
105* FLI1_21867929_ChIP-Seq_TH2_Mouse1.14703417
106TCF4_18268006_ChIP-ChIP_LS174T_Human1.14488768
107* SOX9_26525672_Chip-Seq_HEART_Mouse1.13839240
108PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.13384080
109SOX9_24532713_ChIP-Seq_HFSC_Mouse1.12840616
110RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.12509960
111CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11648887
112NRF2_20460467_ChIP-Seq_MEFs_Mouse1.11142035
113NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.11142035
114SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.10581447
115RNF2_27304074_Chip-Seq_NSC_Mouse1.09899786
116* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09228184
117CTNNB1_20460455_ChIP-Seq_HCT116_Human1.09213952
118CJUN_26792858_Chip-Seq_BT549_Human1.08923678
119GATA1_22025678_ChIP-Seq_K562_Human1.08716849
120ELK1_19687146_ChIP-ChIP_HELA_Human1.08659678
121MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.07854488
122FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.07449170
123CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.07387464
124* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.07366278
125CDX2_22108803_ChIP-Seq_LS180_Human1.06969396
126CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.06401967
127* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05968892
128SMAD4_21799915_ChIP-Seq_A2780_Human1.05247478
129* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.04550639
130* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.03748495
131CIITA_25753668_ChIP-Seq_RAJI_Human1.00387512
132FOXM1_26456572_ChIP-Seq_MCF-7_Human1.00384445
133NANOG_16153702_ChIP-ChIP_HESCs_Human0.99144526
134EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.97497137
135STAT3_23295773_ChIP-Seq_U87_Human0.96179414
136ARNT_22903824_ChIP-Seq_MCF-7_Human0.95602088
137FLI1_27457419_Chip-Seq_LIVER_Mouse0.95340400
138* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.95161921
139* TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.94408848
140SOX2_16153702_ChIP-ChIP_HESCs_Human0.94120821
141* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93867161
142SALL4_18804426_ChIP-ChIP_XEN_Mouse0.93497286
143ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.91773078
144RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.90521972
145ZNF274_21170338_ChIP-Seq_K562_Hela0.90056342
146* SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.89794455
147SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.89084649
148SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.89084649
149* MYCN_18555785_ChIP-Seq_MESCs_Mouse0.87909185
150SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.87702619
151SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.87636577
152NR3C1_21868756_ChIP-Seq_MCF10A_Human0.87145677
153TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.87069000
154MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.86339179
155AR_25329375_ChIP-Seq_VCAP_Human0.85799639
156TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84954583
157POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.84954583
158TOP2B_26459242_ChIP-Seq_MCF-7_Human0.83886417
159LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.82661337
160* SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.81661345

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000372_irregular_coat_pigmentation5.71912252
2MP0005171_absent_coat_pigmentation4.70268866
3MP0003136_yellow_coat_color4.39909290
4MP0010030_abnormal_orbit_morphology3.74094279
5MP0000015_abnormal_ear_pigmentation3.20894574
6MP0009379_abnormal_foot_pigmentation3.16735828
7MP0000537_abnormal_urethra_morphology2.32927594
8MP0005253_abnormal_eye_physiology2.23783391
9MP0000371_diluted_coat_color2.21179785
10MP0002638_abnormal_pupillary_reflex2.19698691
11MP0005075_abnormal_melanosome_morpholog2.13783740
12MP0001984_abnormal_olfaction2.12801457
13MP0008057_abnormal_DNA_replication2.09476215
14MP0000566_synostosis2.08119218
15MP0003567_abnormal_fetal_cardiomyocyte2.03284754
16MP0003705_abnormal_hypodermis_morpholog2.02141725
17MP0010368_abnormal_lymphatic_system2.00684531
18MP0005409_darkened_coat_color1.98261354
19MP0002837_dystrophic_cardiac_calcinosis1.94730396
20MP0003121_genomic_imprinting1.89279482
21MP0004036_abnormal_muscle_relaxation1.86922411
22MP0001324_abnormal_eye_pigmentation1.81280926
23MP0002938_white_spotting1.81053484
24MP0002249_abnormal_larynx_morphology1.79946246
25MP0002090_abnormal_vision1.79734581
26MP0003942_abnormal_urinary_system1.77490381
27MP0000049_abnormal_middle_ear1.76641295
28MP0004233_abnormal_muscle_weight1.72481859
29MP0005408_hypopigmentation1.71481215
30MP0003937_abnormal_limbs/digits/tail_de1.71176106
31MP0003385_abnormal_body_wall1.70647602
32MP0000751_myopathy1.69588308
33MP0009053_abnormal_anal_canal1.68595004
34MP0003787_abnormal_imprinting1.67525911
35MP0009250_abnormal_appendicular_skeleto1.65670147
36MP0005551_abnormal_eye_electrophysiolog1.63935772
37MP0000427_abnormal_hair_cycle1.63474654
38MP0008789_abnormal_olfactory_epithelium1.62258188
39MP0003935_abnormal_craniofacial_develop1.60545719
40MP0003123_paternal_imprinting1.59784748
41MP0002877_abnormal_melanocyte_morpholog1.56670417
42MP0009046_muscle_twitch1.53199445
43MP0003941_abnormal_skin_development1.51437796
44MP0010094_abnormal_chromosome_stability1.51161923
45MP0002102_abnormal_ear_morphology1.45109382
46MP0005187_abnormal_penis_morphology1.44754439
47MP0006072_abnormal_retinal_apoptosis1.43802768
48MP0002932_abnormal_joint_morphology1.42929034
49MP0001299_abnormal_eye_distance/1.42028258
50MP0000534_abnormal_ureter_morphology1.39448218
51MP0006054_spinal_hemorrhage1.38595900
52MP0008877_abnormal_DNA_methylation1.35855815
53MP0008438_abnormal_cutaneous_collagen1.34595664
54MP0002233_abnormal_nose_morphology1.34390732
55MP0002075_abnormal_coat/hair_pigmentati1.34244376
56MP0001188_hyperpigmentation1.33915057
57MP0005379_endocrine/exocrine_gland_phen1.32528256
58MP0003950_abnormal_plasma_membrane1.32446110
59MP0002109_abnormal_limb_morphology1.30068928
60MP0005275_abnormal_skin_tensile1.28944657
61MP0002177_abnormal_outer_ear1.28646089
62MP0002116_abnormal_craniofacial_bone1.26270261
63MP0003077_abnormal_cell_cycle1.24609213
64MP0005174_abnormal_tail_pigmentation1.24567014
65MP0003755_abnormal_palate_morphology1.23606226
66MP0002163_abnormal_gland_morphology1.22073358
67MP0004215_abnormal_myocardial_fiber1.21945939
68MP0008007_abnormal_cellular_replicative1.21366152
69MP0008058_abnormal_DNA_repair1.19850009
70MP0004484_altered_response_of1.18993549
71MP0004808_abnormal_hematopoietic_stem1.18284330
72MP0002332_abnormal_exercise_endurance1.17875833
73MP0004084_abnormal_cardiac_muscle1.16537857
74MP0000569_abnormal_digit_pigmentation1.16218857
75MP0004381_abnormal_hair_follicle1.15908074
76MP0000432_abnormal_head_morphology1.15364595
77MP0003693_abnormal_embryo_hatching1.15224764
78MP0009384_cardiac_valve_regurgitation1.14468092
79MP0003890_abnormal_embryonic-extraembry1.14001694
80MP0005248_abnormal_Harderian_gland1.13041627
81MP0002084_abnormal_developmental_patter1.10755344
82MP0005423_abnormal_somatic_nervous1.10345571
83MP0002653_abnormal_ependyma_morphology1.08780520
84MP0002127_abnormal_cardiovascular_syste1.08588618
85MP0002160_abnormal_reproductive_system1.07787152
86MP0004147_increased_porphyrin_level1.07593842
87MP0005508_abnormal_skeleton_morphology1.06118779
88MP0005503_abnormal_tendon_morphology1.05493737
89MP0002396_abnormal_hematopoietic_system1.05490562
90MP0002114_abnormal_axial_skeleton1.05407903
91MP0002060_abnormal_skin_morphology1.04567376
92MP0002085_abnormal_embryonic_tissue1.04339888
93MP0003943_abnormal_hepatobiliary_system1.03469153
94MP0004957_abnormal_blastocyst_morpholog1.02832218
95MP0009703_decreased_birth_body1.02608297
96MP0010234_abnormal_vibrissa_follicle1.02589099
97MP0003315_abnormal_perineum_morphology1.02454067
98MP0004134_abnormal_chest_morphology1.01865170
99MP0003011_delayed_dark_adaptation1.01486800
100MP0003984_embryonic_growth_retardation1.00670286
101MP0002088_abnormal_embryonic_growth/wei0.99843704
102MP0001293_anophthalmia0.99489722
103MP0001485_abnormal_pinna_reflex0.99260229
104MP0002229_neurodegeneration0.98941210
105MP0001697_abnormal_embryo_size0.98768407
106MP0003111_abnormal_nucleus_morphology0.97895265
107MP0002269_muscular_atrophy0.97474958
108MP0002896_abnormal_bone_mineralization0.96137397
109MP0000749_muscle_degeneration0.95910308
110MP0005380_embryogenesis_phenotype0.95855412
111MP0001672_abnormal_embryogenesis/_devel0.95855412
112MP0002254_reproductive_system_inflammat0.95594271
113MP0003646_muscle_fatigue0.95473959
114MP0005620_abnormal_muscle_contractility0.95248240
115MP0005391_vision/eye_phenotype0.94906159
116MP0001186_pigmentation_phenotype0.94545283
117MP0008932_abnormal_embryonic_tissue0.94359501
118MP0002210_abnormal_sex_determination0.92763399
119MP0000266_abnormal_heart_morphology0.92552600
120MP0004145_abnormal_muscle_electrophysio0.91817664
121MP0005671_abnormal_response_to0.90133485
122MP0002972_abnormal_cardiac_muscle0.90043812
123MP0001929_abnormal_gametogenesis0.89955721
124MP0008775_abnormal_heart_ventricle0.89290891
125MP0000428_abnormal_craniofacial_morphol0.88515356
126MP0005266_abnormal_metabolism0.86930969
127MP0000383_abnormal_hair_follicle0.86878910
128MP0003119_abnormal_digestive_system0.86125541
129MP0005394_taste/olfaction_phenotype0.85998741
130MP0005499_abnormal_olfactory_system0.85998741
131MP0005386_behavior/neurological_phenoty0.85287516
132MP0004924_abnormal_behavior0.85287516
133MP0003115_abnormal_respiratory_system0.85160066
134MP0002095_abnormal_skin_pigmentation0.84601830
135MP0005389_reproductive_system_phenotype0.83523734
136MP0000377_abnormal_hair_follicle0.83471405
137MP0004142_abnormal_muscle_tone0.83372429
138MP0005076_abnormal_cell_differentiation0.82541479
139MP0001919_abnormal_reproductive_system0.82380642
140MP0002106_abnormal_muscle_physiology0.82048187
141MP0010678_abnormal_skin_adnexa0.81881624
142MP0005257_abnormal_intraocular_pressure0.81484763
143MP0004272_abnormal_basement_membrane0.80354293
144MP0002111_abnormal_tail_morphology0.79603115
145MP0005058_abnormal_lysosome_morphology0.78097889
146MP0004130_abnormal_muscle_cell0.77511124
147MP0003137_abnormal_impulse_conducting0.77412700
148MP0006276_abnormal_autonomic_nervous0.76664849
149MP0003172_abnormal_lysosome_physiology0.72362579
150MP0005647_abnormal_sex_gland0.71502081
151MP0001486_abnormal_startle_reflex0.70976605
152MP0001986_abnormal_taste_sensitivity0.67724574
153MP0005195_abnormal_posterior_eye0.67561261
154MP0003195_calcinosis0.66471301
155MP0005167_abnormal_blood-brain_barrier0.65994415
156MP0000747_muscle_weakness0.62899578
157MP0004085_abnormal_heartbeat0.62896248
158MP0001963_abnormal_hearing_physiology0.62603783
159MP0002067_abnormal_sensory_capabilities0.61808309
160MP0005645_abnormal_hypothalamus_physiol0.60823788
161MP0003698_abnormal_male_reproductive0.60790142
162MP0001529_abnormal_vocalization0.59598512
163MP0005369_muscle_phenotype0.58859596
164MP0002557_abnormal_social/conspecific_i0.57060916
165MP0004043_abnormal_pH_regulation0.55184139
166MP0004087_abnormal_muscle_fiber0.55033577
167MP0003183_abnormal_peptide_metabolism0.54765983
168MP0006036_abnormal_mitochondrial_physio0.54661558
169MP0000631_abnormal_neuroendocrine_gland0.52769875
170MP0002752_abnormal_somatic_nervous0.52432814
171MP0000778_abnormal_nervous_system0.51269153
172MP0003880_abnormal_central_pattern0.50422430
173MP0010307_abnormal_tumor_latency0.50354523

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolipid metabolism (HP:0010969)4.60481150
2Abnormality of liposaccharide metabolism (HP:0010968)4.60481150
3Abnormality of glycosphingolipid metabolism (HP:0004343)4.60481150
4Hypoplastic labia majora (HP:0000059)4.40307385
5Abnormality of the labia majora (HP:0012881)4.02711276
6Aplasia/Hypoplasia of the fovea (HP:0008060)4.02465487
7Hypoplasia of the fovea (HP:0007750)4.02465487
8Metaphyseal dysplasia (HP:0100255)3.52197391
9Papilledema (HP:0001085)3.42839097
10Hyperventilation (HP:0002883)3.38354460
11Abnormality of the fovea (HP:0000493)3.30245421
12Blue irides (HP:0000635)3.26291727
13Exercise-induced muscle cramps (HP:0003710)3.02041447
14Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.95744816
15Short 4th metacarpal (HP:0010044)2.92100094
16Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.92100094
17Lip pit (HP:0100267)2.89808197
18Labial hypoplasia (HP:0000066)2.85989919
19Muscle fiber inclusion bodies (HP:0100299)2.85284306
20Disinhibition (HP:0000734)2.84983090
21Nemaline bodies (HP:0003798)2.82707468
22Renal duplication (HP:0000075)2.81423644
23Inappropriate behavior (HP:0000719)2.69552118
24Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.68858952
25Tubulointerstitial nephritis (HP:0001970)2.65339449
26Hypoplastic female external genitalia (HP:0012815)2.62562373
27White forelock (HP:0002211)2.62294216
28Nephronophthisis (HP:0000090)2.61000965
29Abnormality of the 4th metacarpal (HP:0010012)2.60558952
30Pancreatic cysts (HP:0001737)2.59528975
31Aplasia/Hypoplasia of the macula (HP:0008059)2.55660794
32Papillary thyroid carcinoma (HP:0002895)2.54772093
33Chronic hepatic failure (HP:0100626)2.54027730
34Hypophosphatemic rickets (HP:0004912)2.49690220
35Generalized hypopigmentation of hair (HP:0011358)2.46659118
36Aplasia/Hypoplasia of the sternum (HP:0006714)2.45702772
37Occipital encephalocele (HP:0002085)2.45642565
38Albinism (HP:0001022)2.45005046
39Ankle contracture (HP:0006466)2.40629235
40Calf muscle hypertrophy (HP:0008981)2.39438008
41Tubular atrophy (HP:0000092)2.39413006
42Congenital hepatic fibrosis (HP:0002612)2.38321814
43Abnormality of the renal medulla (HP:0100957)2.38296809
44Polydipsia (HP:0001959)2.38131519
45Abnormal drinking behavior (HP:0030082)2.38131519
46Facial diplegia (HP:0001349)2.37911986
47Volvulus (HP:0002580)2.36195505
48Aplasia/Hypoplasia of the uvula (HP:0010293)2.35189289
49Deep philtrum (HP:0002002)2.34946097
50Abnormality of the right ventricle (HP:0001707)2.34805520
51Broad palm (HP:0001169)2.34550301
52Cutaneous finger syndactyly (HP:0010554)2.34147390
53Short middle phalanx of the 5th finger (HP:0004220)2.34132517
54Abnormality of the calf musculature (HP:0001430)2.33972723
55Congenital sensorineural hearing impairment (HP:0008527)2.32398412
56Tubulointerstitial abnormality (HP:0001969)2.31755427
57Aplasia/Hypoplasia affecting the retina (HP:0008061)2.30346730
58Abnormality of the vertebral endplates (HP:0005106)2.29407936
59Mesomelia (HP:0003027)2.27573355
60Muscle hypertrophy of the lower extremities (HP:0008968)2.26837299
61Metaphyseal irregularity (HP:0003025)2.25210063
62Molar tooth sign on MRI (HP:0002419)2.22959972
63Abnormality of midbrain morphology (HP:0002418)2.22959972
64Chronic bronchitis (HP:0004469)2.22246761
65Increased nuchal translucency (HP:0010880)2.21448322
66Hip dysplasia (HP:0001385)2.21402286
67Abnormal ciliary motility (HP:0012262)2.20914815
68Shallow orbits (HP:0000586)2.20825152
69Midline defect of the nose (HP:0004122)2.19760875
70Ocular albinism (HP:0001107)2.19559592
71Missing ribs (HP:0000921)2.17377835
72Broad-based gait (HP:0002136)2.15843670
73True hermaphroditism (HP:0010459)2.15347396
74Diastasis recti (HP:0001540)2.15239539
75Patchy hypopigmentation of hair (HP:0011365)2.15108585
76Iris hypopigmentation (HP:0007730)2.14970879
77Colon cancer (HP:0003003)2.14704671
78Abnormality of the labia (HP:0000058)2.14403566
79Morphological abnormality of the middle ear (HP:0008609)2.12568012
80Frequent falls (HP:0002359)2.12544895
81Pancreatic fibrosis (HP:0100732)2.11723599
82Distal arthrogryposis (HP:0005684)2.10693175
83Cutaneous syndactyly (HP:0012725)2.09979942
84Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.08555145
85Sudden death (HP:0001699)2.08400738
86Aplasia/Hypoplasia of the tongue (HP:0010295)2.07503480
87Left ventricular hypertrophy (HP:0001712)2.05907495
88Abnormality of the renal cortex (HP:0011035)2.05679609
89Generalized hypopigmentation (HP:0007513)2.02931227
90Median cleft lip (HP:0000161)2.02757899
91Exercise-induced myalgia (HP:0003738)2.02748620
92Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.02452834
93Increased cerebral lipofuscin (HP:0011813)2.02047238
94Premature skin wrinkling (HP:0100678)1.99769062
95Cystic liver disease (HP:0006706)1.99218157
96Long eyelashes (HP:0000527)1.98804577
97Congenital stationary night blindness (HP:0007642)1.97826070
98Autoimmune thrombocytopenia (HP:0001973)1.97724408
99Gonadotropin excess (HP:0000837)1.96958631
100Asymmetric septal hypertrophy (HP:0001670)1.96162037
101Bell-shaped thorax (HP:0001591)1.95627410
102Subaortic stenosis (HP:0001682)1.94800430
103Abnormality of the left ventricular outflow tract (HP:0011103)1.94800430
104Dynein arm defect of respiratory motile cilia (HP:0012255)1.92895304
105Absent/shortened dynein arms (HP:0200106)1.92895304
106Rectal prolapse (HP:0002035)1.91455581
107Irregular vertebral endplates (HP:0003301)1.91428354
108Duodenal stenosis (HP:0100867)1.90529165
109Small intestinal stenosis (HP:0012848)1.90529165
110Abnormality of the distal phalanges of the toes (HP:0010182)1.89314786
111Anteriorly placed anus (HP:0001545)1.89187774
112Bundle branch block (HP:0011710)1.88954743
113Wrist flexion contracture (HP:0001239)1.88557918
114Shawl scrotum (HP:0000049)1.88051411
115Rimmed vacuoles (HP:0003805)1.86056096
116Meckel diverticulum (HP:0002245)1.85609746
117Postaxial foot polydactyly (HP:0001830)1.84427478
118Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.83979426
119Fair hair (HP:0002286)1.82803967
120Autoimmune hemolytic anemia (HP:0001890)1.81770001
121Abnormality of the nasal septum (HP:0000419)1.81694195
122Abnormal respiratory motile cilium physiology (HP:0012261)1.81610763
123Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.81594938
124Absent eyebrow (HP:0002223)1.80955306
125Drooling (HP:0002307)1.80738398
126Broad thumb (HP:0011304)1.80555044
127Constricted visual fields (HP:0001133)1.79226221
12811 pairs of ribs (HP:0000878)1.78984686
129Broad phalanges of the hand (HP:0009768)1.78740684
130Narrow palate (HP:0000189)1.78587045
131Bifid tongue (HP:0010297)1.77516146
132Abnormality of calcium-phosphate metabolism (HP:0100530)1.76703207
133Trigonocephaly (HP:0000243)1.76603996
134Neoplasm of the colon (HP:0100273)1.74893925
135Increased number of teeth (HP:0011069)1.74866666
136Acute myeloid leukemia (HP:0004808)1.74775500
137Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.73249815
138Polyuria (HP:0000103)1.72273742
139Tubulointerstitial fibrosis (HP:0005576)1.71831166
140Broad alveolar ridges (HP:0000187)1.71538380
141Thyroiditis (HP:0100646)1.70819584
142Medulloblastoma (HP:0002885)1.70360875
143Rhabdomyosarcoma (HP:0002859)1.69686422
144Renal cortical cysts (HP:0000803)1.69268877
145Abnormality of the ileum (HP:0001549)1.68750459
146Medial flaring of the eyebrow (HP:0010747)1.67811950
147Broad phalanx (HP:0006009)1.67771492
148Broad finger (HP:0001500)1.67724914
149Carpal bone hypoplasia (HP:0001498)1.67345038
150Thoracolumbar scoliosis (HP:0002944)1.67329505
151Gaze-evoked nystagmus (HP:0000640)1.67239389
152Microglossia (HP:0000171)1.67055520
153Gait imbalance (HP:0002141)1.66248592
154Genital tract atresia (HP:0001827)1.65582910
155Myoglobinuria (HP:0002913)1.65338209
156Oculomotor apraxia (HP:0000657)1.64806628
157Congenital primary aphakia (HP:0007707)1.64759260
158Abnormality of chromosome stability (HP:0003220)1.64240284
159Single transverse palmar crease (HP:0000954)1.63715762
160Dialeptic seizures (HP:0011146)1.63689873
161Poor coordination (HP:0002370)1.63663161
162Abnormal biliary tract physiology (HP:0012439)1.63405915
163Bile duct proliferation (HP:0001408)1.63405915
164Nephrogenic diabetes insipidus (HP:0009806)1.63029505
165Broad toe (HP:0001837)1.62805595
166Neoplasm of the small intestine (HP:0100833)1.62337404
167Broad long bones (HP:0005622)1.62185568
168Aplasia/Hypoplasia of the tibia (HP:0005772)1.61342548
169Overriding aorta (HP:0002623)1.61101819
170Abnormality of the phalanges of the 5th finger (HP:0004213)1.60267796
171Vaginal atresia (HP:0000148)1.59774451
172Abnormal hair whorl (HP:0010721)1.58467458
173Deviation of the thumb (HP:0009603)1.57412926
174Dental malocclusion (HP:0000689)1.57156172
175Truncal obesity (HP:0001956)1.56936460
176Renovascular hypertension (HP:0100817)1.55469770
177Short metatarsal (HP:0010743)1.55400293
178Hyperacusis (HP:0010780)1.55172361
179Abnormality of the fingertips (HP:0001211)1.55035720
180Abnormality of the calcaneus (HP:0008364)1.54360037
181Proximal placement of thumb (HP:0009623)1.54272203

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EEF2K3.22692926
2CDC73.08376588
3PLK42.81768196
4EPHB22.77915322
5PNCK2.60468509
6ICK2.55573889
7ACVR1B2.34683619
8STK392.24750707
9WNK32.13181836
10NEK22.08870548
11PINK12.04274511
12TAOK12.02546983
13MAPKAPK31.98327863
14TGFBR11.95083790
15LATS11.93475206
16TAOK31.93128801
17CAMK1G1.87114904
18STK241.75662530
19PLK31.74550388
20ARAF1.72813625
21PHKG11.72434847
22PHKG21.72434847
23ERBB31.71050013
24BRSK21.70187253
25BRAF1.69864015
26NUAK11.66162242
27FGFR21.56440418
28TNIK1.52144822
29SGK21.51025198
30MAP2K31.42970045
31AKT31.42754649
32PDK41.41973903
33PDK31.41973903
34CSNK1G21.39029800
35MAP3K61.36721367
36CDK81.35961218
37FRK1.35044483
38TTK1.33533228
39ADRBK21.30617646
40MAPK131.29135353
41MKNK11.23057833
42MAP3K31.22576695
43CSNK1G11.22407205
44TXK1.22118474
45RPS6KA21.21584997
46STK31.21241025
47CCNB11.20879418
48MAP3K41.19812890
49FGFR31.19111675
50SIK11.18934674
51PLK21.17698548
52OBSCN1.17625334
53FGFR11.16339902
54BCKDK1.13175868
55RPS6KB21.12915225
56MARK31.12337371
57RPS6KA41.11468613
58MAP4K21.08192926
59GRK71.08176811
60CDK31.07275764
61DMPK1.07236390
62TRIM281.06727384
63SRPK11.06622754
64MUSK1.02457730
65CSNK1G31.01797850
66PIM20.99627715
67VRK10.98316045
68TRPM70.97295543
69TTN0.96973216
70RPS6KC10.96584203
71RPS6KL10.96584203
72PLK10.94076269
73RAF10.92566357
74PASK0.92094075
75BMPR1B0.91627691
76CSNK1A1L0.91519776
77OXSR10.89349058
78CAMK40.88520631
79ZAK0.87706057
80GRK10.87083235
81CAMK1D0.86620386
82SIK30.86554338
83AURKB0.86002016
84RPS6KA60.85494097
85PRKAA10.84643201
86MARK10.84160324
87MARK20.84081479
88NLK0.83348456
89NEK90.82047810
90SGK30.80969289
91CHEK20.80674488
92WEE10.79732475
93EPHA30.76277186
94TIE10.74995132
95CAMK2A0.74361724
96TEC0.73143062
97WNK10.72828082
98STK38L0.72453993
99CAMK10.72360907
100MST40.70191516
101WNK40.69316915
102CASK0.69034173
103PRKD30.68854285
104CAMK2D0.68558423
105SGK4940.67713298
106SGK2230.67713298
107PKN10.67097859
108RPS6KB10.66236161
109CAMKK20.66163206
110PRKAA20.65760601
111MKNK20.65560208
112TAOK20.64739830
113TSSK60.64062357
114ERBB20.63185788
115MAPKAPK50.62951049
116PRKACB0.61943008
117MAP2K70.61752283
118ATR0.60917281
119ATM0.59400721
120KIT0.59065442
121EIF2AK20.56927385
122BCR0.56457166
123DYRK20.55396879
124CDK60.54791426
125PAK30.54704031
126NEK10.54598904
127CHEK10.54466289
128RPS6KA50.54166655
129MAP2K40.53595333
130MTOR0.53553000
131ROCK10.53127542
132PRKG10.51365172
133STK160.51301526
134PRKACA0.50811288
135PRKCE0.50389283
136TRIB30.50308867
137BRSK10.49779221
138CDK90.49196586
139DYRK30.49067435
140PIK3CA0.48541685
141ERBB40.48265936
142RET0.46536786
143PIK3CG0.46443036
144NTRK20.46226367
145PDK20.45983294
146MAPK110.45820982
147YES10.45549309
148MAPK90.45036352
149RPS6KA10.44551461
150TGFBR20.43758012
151AURKA0.43020082
152EPHA40.41398231
153DDR20.41137003
154MAP3K70.40699536
155DYRK1A0.39781042
156MAP2K60.36680706
157PRKCG0.36344954
158MAP3K50.35042351
159PRKCQ0.34415130
160STK110.34243440

Predicted pathways (KEGG)

RankGene SetZ-score
1Cell cycle_Homo sapiens_hsa041103.00710489
2Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.96694338
3Collecting duct acid secretion_Homo sapiens_hsa049662.95840332
4Protein export_Homo sapiens_hsa030602.80865703
5Mismatch repair_Homo sapiens_hsa034302.67576516
6Lysosome_Homo sapiens_hsa041422.67242215
7Nitrogen metabolism_Homo sapiens_hsa009102.58433838
8Homologous recombination_Homo sapiens_hsa034402.43809967
9Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.41633977
10Fanconi anemia pathway_Homo sapiens_hsa034602.33611574
11Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.30408742
12Cardiac muscle contraction_Homo sapiens_hsa042602.22347420
13Dorso-ventral axis formation_Homo sapiens_hsa043202.19555272
14RNA degradation_Homo sapiens_hsa030182.10818842
15DNA replication_Homo sapiens_hsa030302.09806698
16Rheumatoid arthritis_Homo sapiens_hsa053232.09778165
17Colorectal cancer_Homo sapiens_hsa052102.04905000
18Primary bile acid biosynthesis_Homo sapiens_hsa001202.02384311
19Basal cell carcinoma_Homo sapiens_hsa052171.96501596
20Oxidative phosphorylation_Homo sapiens_hsa001901.95641995
21Glycosaminoglycan degradation_Homo sapiens_hsa005311.92567931
22Base excision repair_Homo sapiens_hsa034101.88606028
23Ether lipid metabolism_Homo sapiens_hsa005651.71457969
24Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.66739299
25Circadian rhythm_Homo sapiens_hsa047101.54872919
26Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.52864595
27RNA transport_Homo sapiens_hsa030131.51580970
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.51335643
29Endometrial cancer_Homo sapiens_hsa052131.50000991
30Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.48509334
31MicroRNAs in cancer_Homo sapiens_hsa052061.48074472
32Phototransduction_Homo sapiens_hsa047441.47374781
33Basal transcription factors_Homo sapiens_hsa030221.46581213
34Hedgehog signaling pathway_Homo sapiens_hsa043401.45292322
35mRNA surveillance pathway_Homo sapiens_hsa030151.44598913
36Oocyte meiosis_Homo sapiens_hsa041141.41308464
37Parkinsons disease_Homo sapiens_hsa050121.39317865
38Pancreatic cancer_Homo sapiens_hsa052121.39048574
39Linoleic acid metabolism_Homo sapiens_hsa005911.38157223
40Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.37375034
41Small cell lung cancer_Homo sapiens_hsa052221.37043715
42Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.36987489
43Hippo signaling pathway_Homo sapiens_hsa043901.36775811
44mTOR signaling pathway_Homo sapiens_hsa041501.33433672
45TGF-beta signaling pathway_Homo sapiens_hsa043501.32415134
46Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.30930213
47Olfactory transduction_Homo sapiens_hsa047401.28847640
48Butanoate metabolism_Homo sapiens_hsa006501.27401496
49Wnt signaling pathway_Homo sapiens_hsa043101.27216618
50Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.24680674
51Caffeine metabolism_Homo sapiens_hsa002321.23160533
52Adherens junction_Homo sapiens_hsa045201.23006260
53Dilated cardiomyopathy_Homo sapiens_hsa054141.22724466
54Selenocompound metabolism_Homo sapiens_hsa004501.21986592
55Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.21734224
56Spliceosome_Homo sapiens_hsa030401.21214227
57Tryptophan metabolism_Homo sapiens_hsa003801.20479983
58Viral myocarditis_Homo sapiens_hsa054161.19018487
59Focal adhesion_Homo sapiens_hsa045101.18755649
60Thyroid hormone signaling pathway_Homo sapiens_hsa049191.18642482
61ECM-receptor interaction_Homo sapiens_hsa045121.17523960
62Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.17469047
63p53 signaling pathway_Homo sapiens_hsa041151.17341906
64alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.14587274
65Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.13617983
66Lysine degradation_Homo sapiens_hsa003101.12197564
67AMPK signaling pathway_Homo sapiens_hsa041521.12178784
68HTLV-I infection_Homo sapiens_hsa051661.12008576
69Thyroid cancer_Homo sapiens_hsa052161.11666453
70Non-homologous end-joining_Homo sapiens_hsa034501.11466971
71Nucleotide excision repair_Homo sapiens_hsa034201.09975649
72Transcriptional misregulation in cancer_Homo sapiens_hsa052021.09718316
73Insulin signaling pathway_Homo sapiens_hsa049101.08982776
74Pathways in cancer_Homo sapiens_hsa052001.08081092
75Chronic myeloid leukemia_Homo sapiens_hsa052201.07099331
76Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.06668321
77Glucagon signaling pathway_Homo sapiens_hsa049221.05604889
78Peroxisome_Homo sapiens_hsa041461.00589683
79Alzheimers disease_Homo sapiens_hsa050100.99615547
80Calcium signaling pathway_Homo sapiens_hsa040200.99109218
81Insulin resistance_Homo sapiens_hsa049310.99062804
82Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.99024293
83Viral carcinogenesis_Homo sapiens_hsa052030.98408266
84Systemic lupus erythematosus_Homo sapiens_hsa053220.97918836
85Alcoholism_Homo sapiens_hsa050340.96897002
86Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.96304829
87Prostate cancer_Homo sapiens_hsa052150.96182556
88Proteoglycans in cancer_Homo sapiens_hsa052050.95376985
89Melanoma_Homo sapiens_hsa052180.92725805
90Oxytocin signaling pathway_Homo sapiens_hsa049210.91883445
91Epstein-Barr virus infection_Homo sapiens_hsa051690.90492950
92Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.89099114
93Intestinal immune network for IgA production_Homo sapiens_hsa046720.86333551
94N-Glycan biosynthesis_Homo sapiens_hsa005100.85619954
95Allograft rejection_Homo sapiens_hsa053300.85509404
96Huntingtons disease_Homo sapiens_hsa050160.83864349
97Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.83420794
98Tight junction_Homo sapiens_hsa045300.83328207
99Propanoate metabolism_Homo sapiens_hsa006400.82449837
100Asthma_Homo sapiens_hsa053100.82303397
101cGMP-PKG signaling pathway_Homo sapiens_hsa040220.82058365
102RNA polymerase_Homo sapiens_hsa030200.78844417
103Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.78253015
104Steroid biosynthesis_Homo sapiens_hsa001000.77723742
105Axon guidance_Homo sapiens_hsa043600.77688630
106Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.76289224
107Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.75626589
108Fatty acid metabolism_Homo sapiens_hsa012120.75157358
109Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.74926231
110Toxoplasmosis_Homo sapiens_hsa051450.72174645
111PI3K-Akt signaling pathway_Homo sapiens_hsa041510.72043785
112Pyrimidine metabolism_Homo sapiens_hsa002400.71095218
113Non-small cell lung cancer_Homo sapiens_hsa052230.71090510
114Regulation of autophagy_Homo sapiens_hsa041400.70741369
115Circadian entrainment_Homo sapiens_hsa047130.69918145
116Purine metabolism_Homo sapiens_hsa002300.68237555
117Neurotrophin signaling pathway_Homo sapiens_hsa047220.67780071
118Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.67688649
119Autoimmune thyroid disease_Homo sapiens_hsa053200.67143995
120Type I diabetes mellitus_Homo sapiens_hsa049400.66030284
121Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.65095875
1222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.64740324
123Nicotine addiction_Homo sapiens_hsa050330.64273599
124Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.63445571
125Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.62150349
126ErbB signaling pathway_Homo sapiens_hsa040120.59938531
127Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59734379
128Renin secretion_Homo sapiens_hsa049240.58168328
129Long-term depression_Homo sapiens_hsa047300.57818208
130Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.56383923
131Fatty acid degradation_Homo sapiens_hsa000710.56196646
132FoxO signaling pathway_Homo sapiens_hsa040680.55414445
133Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.55204335
134Ovarian steroidogenesis_Homo sapiens_hsa049130.54689858
135Platelet activation_Homo sapiens_hsa046110.53697728
136Graft-versus-host disease_Homo sapiens_hsa053320.53111064
137Melanogenesis_Homo sapiens_hsa049160.53101813
138Phagosome_Homo sapiens_hsa041450.53042412
139Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.52764714
140RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.52272763
141Tuberculosis_Homo sapiens_hsa051520.52080070
142Notch signaling pathway_Homo sapiens_hsa043300.50992432
143Insulin secretion_Homo sapiens_hsa049110.50498833
144Prolactin signaling pathway_Homo sapiens_hsa049170.50318197
145Vascular smooth muscle contraction_Homo sapiens_hsa042700.50298693
146Mineral absorption_Homo sapiens_hsa049780.49669949
147Rap1 signaling pathway_Homo sapiens_hsa040150.49072196
148Amoebiasis_Homo sapiens_hsa051460.48240713
149Renal cell carcinoma_Homo sapiens_hsa052110.48063265
150VEGF signaling pathway_Homo sapiens_hsa043700.46404552
151Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46051798
152Other glycan degradation_Homo sapiens_hsa005110.45284763
153Renin-angiotensin system_Homo sapiens_hsa046140.44292457
154Jak-STAT signaling pathway_Homo sapiens_hsa046300.44118150
155Pyruvate metabolism_Homo sapiens_hsa006200.43652787
156MAPK signaling pathway_Homo sapiens_hsa040100.41665313
157Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.41263619
158Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.41021586
159Morphine addiction_Homo sapiens_hsa050320.38731626
160Osteoclast differentiation_Homo sapiens_hsa043800.34876489
161Pancreatic secretion_Homo sapiens_hsa049720.28699412
162Cysteine and methionine metabolism_Homo sapiens_hsa002700.28524956
163Primary immunodeficiency_Homo sapiens_hsa053400.27029394
164Metabolic pathways_Homo sapiens_hsa011000.26149031
165Dopaminergic synapse_Homo sapiens_hsa047280.25588769
166Salivary secretion_Homo sapiens_hsa049700.24257104
167ABC transporters_Homo sapiens_hsa020100.23980427
168Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.21605313

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