TDRD5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* DNA methylation involved in gamete generation (GO:0043046)9.95537513
2cilium or flagellum-dependent cell motility (GO:0001539)9.24466743
3synaptonemal complex organization (GO:0070193)9.20622166
4synaptonemal complex assembly (GO:0007130)9.11501789
5glomerular visceral epithelial cell development (GO:0072015)8.90412281
6glomerular epithelial cell development (GO:0072310)7.90440568
7male meiosis I (GO:0007141)7.14938904
8sphingosine metabolic process (GO:0006670)7.12577705
9diol metabolic process (GO:0034311)6.92747077
10regulation of meiosis I (GO:0060631)6.90946741
11chromosome organization involved in meiosis (GO:0070192)6.83199082
12glomerular basement membrane development (GO:0032836)6.76494949
13meiotic nuclear division (GO:0007126)6.73789699
14fusion of sperm to egg plasma membrane (GO:0007342)6.50354859
15gene silencing by RNA (GO:0031047)6.03448914
16sphingoid metabolic process (GO:0046519)5.96076245
17multicellular organism reproduction (GO:0032504)5.88949709
18axonemal dynein complex assembly (GO:0070286)5.85056612
19meiosis I (GO:0007127)5.82501233
20sperm motility (GO:0030317)5.82137683
21sperm-egg recognition (GO:0035036)5.80144801
22binding of sperm to zona pellucida (GO:0007339)5.76873633
23acrosome assembly (GO:0001675)5.49339176
24* spermatid development (GO:0007286)5.40896267
25meiotic cell cycle (GO:0051321)5.28514478
26cell-cell recognition (GO:0009988)5.18412974
27motile cilium assembly (GO:0044458)5.05510046
28plasma membrane fusion (GO:0045026)4.95951104
29histone H3-K9 demethylation (GO:0033169)4.90419465
30epithelial cilium movement (GO:0003351)4.87329749
31histone H3-K36 demethylation (GO:0070544)4.86164317
32meiotic cell cycle process (GO:1903046)4.82495134
33glomerulus development (GO:0032835)4.82402510
34* DNA alkylation (GO:0006305)4.78017198
35* DNA methylation (GO:0006306)4.78017198
36paraxial mesoderm development (GO:0048339)4.69889228
37epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.60697886
38nuclear pore complex assembly (GO:0051292)4.52348685
39synapsis (GO:0007129)4.49702178
40reproduction (GO:0000003)4.49205182
41genitalia morphogenesis (GO:0035112)4.38549224
42cilium movement (GO:0003341)4.32760730
43acrosome reaction (GO:0007340)4.29773875
44fertilization (GO:0009566)4.29264086
45* germ cell development (GO:0007281)4.28588129
46mitotic sister chromatid cohesion (GO:0007064)4.22913596
47spermatogenesis (GO:0007283)4.16617441
48male gamete generation (GO:0048232)4.15785951
49gene silencing (GO:0016458)4.13996586
50nuclear pore organization (GO:0006999)4.05821584
51single fertilization (GO:0007338)3.98276747
52sister chromatid cohesion (GO:0007062)3.94812524
53gamete generation (GO:0007276)3.93893650
54regulation of odontogenesis of dentin-containing tooth (GO:0042487)3.92159420
55gonadal mesoderm development (GO:0007506)3.91005939
56oogenesis (GO:0048477)3.89165504
57monoubiquitinated protein deubiquitination (GO:0035520)3.86447620
58* cellular process involved in reproduction in multicellular organism (GO:0022412)3.84514332
59positive regulation of meiosis (GO:0045836)3.75579693
60regulation of histone H3-K9 methylation (GO:0051570)3.71120061
61bundle of His cell to Purkinje myocyte communication (GO:0086069)3.70771524
62female gamete generation (GO:0007292)3.69169469
63negative regulation of meiosis (GO:0045835)3.68827456
64* DNA methylation or demethylation (GO:0044728)3.63720897
65reciprocal DNA recombination (GO:0035825)3.63463091
66reciprocal meiotic recombination (GO:0007131)3.63463091
67protein-chromophore linkage (GO:0018298)3.62112962
68centriole assembly (GO:0098534)3.61373076
69regulation of centriole replication (GO:0046599)3.58760283
70meiotic chromosome segregation (GO:0045132)3.55830921
71negative regulation of inclusion body assembly (GO:0090084)3.55393037
72positive regulation of meiotic cell cycle (GO:0051446)3.55148193
73regulation of protein polyubiquitination (GO:1902914)3.53489320
74regulation of cilium movement (GO:0003352)3.47922474
75pore complex assembly (GO:0046931)3.44047756
76microtubule depolymerization (GO:0007019)3.39758811
77negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.39250262
78cell wall macromolecule metabolic process (GO:0044036)3.34789161
79cell wall macromolecule catabolic process (GO:0016998)3.34789161
80positive regulation of translational initiation (GO:0045948)3.31976188
81regulation of meiosis (GO:0040020)3.28309370
82regulation of transforming growth factor beta2 production (GO:0032909)3.26782365
83biotin metabolic process (GO:0006768)3.25567364
84seminiferous tubule development (GO:0072520)3.23597801
85negative regulation of gene silencing (GO:0060969)3.20218478
86nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)3.17604032
87ventricular system development (GO:0021591)3.17494851
88* DNA modification (GO:0006304)3.16287990
89protein localization to cilium (GO:0061512)3.15739738
90notochord development (GO:0030903)3.12860172
91attachment of spindle microtubules to kinetochore (GO:0008608)3.11968827
92protein K6-linked ubiquitination (GO:0085020)3.11539661
93mitotic chromosome condensation (GO:0007076)3.10166044
94regulation of meiotic cell cycle (GO:0051445)3.08444695
95oocyte development (GO:0048599)3.07473882
96embryonic body morphogenesis (GO:0010172)3.07290159
97regulation of transcription from RNA polymerase I promoter (GO:0006356)3.06215237
98multicellular organismal reproductive process (GO:0048609)3.04960122
99sex differentiation (GO:0007548)3.03793923
100regulation of female gonad development (GO:2000194)3.03678954
101sulfate transmembrane transport (GO:1902358)3.03650940
102intestinal epithelial cell development (GO:0060576)2.99293279
103mitotic sister chromatid segregation (GO:0000070)2.96955401
104regulation of pigment cell differentiation (GO:0050932)2.95406346
105sulfate transport (GO:0008272)2.94705995
106V(D)J recombination (GO:0033151)2.94076811
107vitamin transmembrane transport (GO:0035461)2.91808699
108histone exchange (GO:0043486)2.90921199
109regulation of RNA export from nucleus (GO:0046831)2.90740850
110epithelial cell differentiation involved in kidney development (GO:0035850)2.90220421
111negative regulation of cell cycle G2/M phase transition (GO:1902750)2.89681944
112kinetochore organization (GO:0051383)2.88674059
113resolution of meiotic recombination intermediates (GO:0000712)2.87128329
114centriole replication (GO:0007099)2.84387136
115oocyte maturation (GO:0001556)2.84135922
116regulation of inclusion body assembly (GO:0090083)2.82705705
117DNA packaging (GO:0006323)2.82233273
118regulation of protein glycosylation (GO:0060049)2.80215633
119heterochromatin organization (GO:0070828)2.80046630
120negative regulation of DNA repair (GO:0045738)2.78124877
121regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.77046451
122DNA synthesis involved in DNA repair (GO:0000731)2.75328059
123regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.73412202
124growth hormone receptor signaling pathway (GO:0060396)2.71063727
125histone lysine demethylation (GO:0070076)2.70440942
126microtubule severing (GO:0051013)2.68637626
127regulation of chromosome segregation (GO:0051983)2.68024681
128chromosome organization (GO:0051276)2.67078315
129body morphogenesis (GO:0010171)2.66375712
130sister chromatid segregation (GO:0000819)2.64873579
131regulation of interleukin-5 production (GO:0032674)2.64252487
132regulation of DNA endoreduplication (GO:0032875)2.64001714
133protein localization to chromosome (GO:0034502)2.60840736
134somite rostral/caudal axis specification (GO:0032525)2.60516211
135trivalent inorganic anion homeostasis (GO:0072506)2.59592189
136phosphate ion homeostasis (GO:0055062)2.59592189
137lipopolysaccharide biosynthetic process (GO:0009103)2.56087349
138histone demethylation (GO:0016577)2.53856884
139positive regulation of developmental pigmentation (GO:0048087)2.52225439
140peptidyl-lysine dimethylation (GO:0018027)2.52170546
141chromosome condensation (GO:0030261)2.51607661
142face development (GO:0060324)2.51324706
143negative regulation of stem cell proliferation (GO:2000647)2.50447978
144positive regulation of gene expression, epigenetic (GO:0045815)2.47153105
145regulation of centrosome duplication (GO:0010824)2.45774664
146regulation of centrosome cycle (GO:0046605)2.45611313
147piRNA metabolic process (GO:0034587)14.4559990
148male meiosis (GO:0007140)10.2158219

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_20079471_ChIP-ChIP_T-47D_Human6.18970779
2EZH2_22144423_ChIP-Seq_EOC_Human4.65317715
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.75661882
4E2F7_22180533_ChIP-Seq_HELA_Human3.72634927
5RBPJ_22232070_ChIP-Seq_NCS_Mouse3.33721085
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.26800258
7IGF1R_20145208_ChIP-Seq_DFB_Human3.21648440
8ESR1_21235772_ChIP-Seq_MCF-7_Human3.01147084
9TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.83841747
10SALL1_21062744_ChIP-ChIP_HESCs_Human2.77837198
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.61793470
12ZNF217_24962896_ChIP-Seq_MCF-7_Human2.60848592
13AR_21572438_ChIP-Seq_LNCaP_Human2.56766652
14* ER_23166858_ChIP-Seq_MCF-7_Human2.53217999
15ESR2_21235772_ChIP-Seq_MCF-7_Human2.50983978
16ESR1_15608294_ChIP-ChIP_MCF-7_Human2.41294852
17* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.38882412
18GATA1_26923725_Chip-Seq_HPCs_Mouse2.33067010
19PCGF2_27294783_Chip-Seq_ESCs_Mouse2.31182764
20AHR_22903824_ChIP-Seq_MCF-7_Human2.19557893
21HOXB7_26014856_ChIP-Seq_BT474_Human2.17798981
22TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.15075474
23KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.14631474
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.13644996
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.12058482
26ARNT_22903824_ChIP-Seq_MCF-7_Human2.09409681
27ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.07449168
28E2F4_17652178_ChIP-ChIP_JURKAT_Human2.07331296
29RUNX1_27514584_Chip-Seq_MCF-7_Human2.02873119
30BMI1_23680149_ChIP-Seq_NPCS_Mouse2.01097793
31MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse10.3949162
32RNF2_27304074_Chip-Seq_NSC_Mouse1.95268296
33PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.93587088
34FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.86961903
35PCGF2_27294783_Chip-Seq_NPCs_Mouse1.85067314
36MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.77649144
37TDRD3_21172665_ChIP-Seq_MCF-7_Human1.77265687
38TP63_19390658_ChIP-ChIP_HaCaT_Human1.75540657
39GATA3_24758297_ChIP-Seq_MCF-7_Human1.72172479
40TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.65613762
41NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.61878032
42AR_21909140_ChIP-Seq_LNCAP_Human1.60584892
43NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.56714987
44ZNF274_21170338_ChIP-Seq_K562_Hela1.54277280
45EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.51828432
46* NFE2_27457419_Chip-Seq_LIVER_Mouse1.51792563
47* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.50115423
48TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.48729807
49SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.46022805
50* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.43509118
51KDM5A_27292631_Chip-Seq_BREAST_Human1.41453652
52CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.35269275
53PADI4_21655091_ChIP-ChIP_MCF-7_Human1.34662724
54FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.33962978
55WDR5_24793694_ChIP-Seq_LNCAP_Human1.33814823
56RUNX1_26923725_Chip-Seq_HPCs_Mouse1.33344345
57AR_25329375_ChIP-Seq_VCAP_Human1.33210838
58AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.31557297
59SMC4_20622854_ChIP-Seq_HELA_Human1.31410334
60TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30576698
61POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.30576698
62PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.30293834
63* NANOG_18555785_Chip-Seq_ESCs_Mouse1.29147764
64POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.28108712
65MYCN_18555785_ChIP-Seq_MESCs_Mouse1.27500289
66KLF5_25053715_ChIP-Seq_YYC3_Human1.26771720
67MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.24872140
68E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.24835761
69TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.24402504
70* SMAD4_21741376_ChIP-Seq_EPCs_Human1.21941035
71FOXA1_25552417_ChIP-Seq_VCAP_Human1.21290356
72ELK4_26923725_Chip-Seq_MESODERM_Mouse1.19898642
73KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.19665723
74STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.18982157
75ELF5_23300383_ChIP-Seq_T47D_Human1.16919733
76PKCTHETA_26484144_Chip-Seq_BREAST_Human1.15521631
77OCT4_20526341_ChIP-Seq_ESCs_Human1.14561157
78TCF4_18268006_ChIP-ChIP_LS174T_Human1.13361874
79MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.12801633
80STAT1_17558387_ChIP-Seq_HELA_Human1.11402070
81PPAR_26484153_Chip-Seq_NCI-H1993_Human1.11266572
82TCF4_23295773_ChIP-Seq_U87_Human1.11080556
83KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.10845797
84KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.10845797
85KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.10845797
86FUS_26573619_Chip-Seq_HEK293_Human1.10537953
87RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.10484615
88STAT3_23295773_ChIP-Seq_U87_Human1.10280575
89* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.09563715
90RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.08732412
91SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.08012122
92HIF1A_21447827_ChIP-Seq_MCF-7_Human1.07024826
93* E2F1_18555785_Chip-Seq_ESCs_Mouse1.06614151
94AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.06478334
95* OCT4_18555785_Chip-Seq_ESCs_Mouse1.05969160
96E2F1_21310950_ChIP-Seq_MCF-7_Human1.05883224
97RAC3_21632823_ChIP-Seq_H3396_Human1.05501087
98RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05475890
99FOXA1_27270436_Chip-Seq_PROSTATE_Human1.04198617
100FOXA1_25329375_ChIP-Seq_VCAP_Human1.04198617
101TET1_21490601_ChIP-Seq_MESCs_Mouse1.04045568
102KAP1_22055183_ChIP-Seq_ESCs_Mouse1.03245148
103EWS_26573619_Chip-Seq_HEK293_Human1.03138187
104PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.01580927
105* EZH2_27294783_Chip-Seq_NPCs_Mouse1.01298732
106HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.00822390
107* STAT3_18555785_Chip-Seq_ESCs_Mouse0.99526862
108GBX2_23144817_ChIP-Seq_PC3_Human0.98812086
109TP63_23658742_ChIP-Seq_EP156T_Human0.97984004
110FOXA1_21572438_ChIP-Seq_LNCaP_Human0.97966060
111* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.97265822
112* KLF4_18555785_Chip-Seq_ESCs_Mouse0.97177071
113GATA4_25053715_ChIP-Seq_YYC3_Human0.96551773
114* P53_22387025_ChIP-Seq_ESCs_Mouse0.96298872
115* ERA_21632823_ChIP-Seq_H3396_Human0.95516847
116* CMYC_18555785_Chip-Seq_ESCs_Mouse0.94352383
117KDM2B_26808549_Chip-Seq_REH_Human0.94039441
118VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.93811819
119SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.93810004
120CTBP1_25329375_ChIP-Seq_LNCAP_Human0.93600595
121TOP2B_26459242_ChIP-Seq_MCF-7_Human0.93530128
122SOX9_26525672_Chip-Seq_HEART_Mouse0.93150364
123* ZFX_18555785_Chip-Seq_ESCs_Mouse0.92152873
124GATA3_26560356_Chip-Seq_TH1_Human0.92047555
125* SUZ12_18555785_Chip-Seq_ESCs_Mouse0.90709361
126SMAD3_21741376_ChIP-Seq_ESCs_Human0.90567490
127* TBL1_22424771_ChIP-Seq_293T_Human0.90539054
128CTNNB1_20460455_ChIP-Seq_HCT116_Human0.90516087
129OCT1_27270436_Chip-Seq_PROSTATE_Human0.90020313
130RUNX2_22187159_ChIP-Seq_PCA_Human0.89686118
131GATA6_25053715_ChIP-Seq_YYC3_Human0.89678729
132* ESRRB_18555785_Chip-Seq_ESCs_Mouse0.89364661
133TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.89115007
134TBX3_20139965_ChIP-Seq_ESCs_Mouse0.88889622
135* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.88802486
136TBX3_20139965_ChIP-Seq_MESCs_Mouse0.88473499
137FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.87508666
138CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.87386083
139* ETV1_20927104_ChIP-Seq_GIST48_Human0.86455707
140CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.86371304
141TP53_22573176_ChIP-Seq_HFKS_Human0.86210878
142BCAT_22108803_ChIP-Seq_LS180_Human0.86143262
143* P300_18555785_Chip-Seq_ESCs_Mouse0.86051085
144ZFX_18555785_ChIP-Seq_MESCs_Mouse0.85958397
145CBP_20019798_ChIP-Seq_JUKART_Human0.85213764
146IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.85213764
147GATA3_21878914_ChIP-Seq_MCF-7_Human0.85180298
148CBX2_27304074_Chip-Seq_ESCs_Mouse0.85136923
149GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84896953
150* SMAD4_21799915_ChIP-Seq_A2780_Human0.83523801
151ZFP57_27257070_Chip-Seq_ESCs_Mouse0.82720137
152TAL1_26923725_Chip-Seq_HPCs_Mouse0.82619134
153CDX2_22108803_ChIP-Seq_LS180_Human0.81573908
154FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.81571418
155POU3F2_20337985_ChIP-ChIP_501MEL_Human0.81569425
156CTBP2_25329375_ChIP-Seq_LNCAP_Human0.81257872
157* RUNX1_27457419_Chip-Seq_LIVER_Mouse0.80894276
158STAT3_18555785_ChIP-Seq_MESCs_Mouse0.79098609
159* CRX_20693478_ChIP-Seq_RETINA_Mouse0.78907473
160RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.78394675
161LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.77896632
162* NMYC_18555785_Chip-Seq_ESCs_Mouse0.77522868
163CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.76207366
164PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.75831230
165GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.75546612
166FOXM1_26456572_ChIP-Seq_MCF-7_Human0.75341778

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation7.91689561
2MP0005410_abnormal_fertilization6.72866254
3MP0001929_abnormal_gametogenesis4.60637970
4MP0002210_abnormal_sex_determination4.26942874
5MP0003136_yellow_coat_color4.16847208
6MP0003698_abnormal_male_reproductive4.12800422
7MP0002837_dystrophic_cardiac_calcinosis3.98124095
8MP0010094_abnormal_chromosome_stability3.47400634
9MP0001145_abnormal_male_reproductive3.39448193
10MP0000383_abnormal_hair_follicle3.19360451
11MP0000653_abnormal_sex_gland3.17578670
12MP0008995_early_reproductive_senescence3.04323152
13MP0005171_absent_coat_pigmentation3.02090293
14MP0008057_abnormal_DNA_replication2.97291603
15MP0010678_abnormal_skin_adnexa2.79864519
16MP0005623_abnormal_meninges_morphology2.54452293
17MP0002161_abnormal_fertility/fecundity2.54104660
18MP0010234_abnormal_vibrissa_follicle2.52477918
19MP0003879_abnormal_hair_cell2.49879707
20MP0003111_abnormal_nucleus_morphology2.49673022
21MP0008058_abnormal_DNA_repair2.49134980
22MP0004381_abnormal_hair_follicle2.41660516
23MP0003786_premature_aging2.29085798
24MP0002160_abnormal_reproductive_system2.20333206
25MP0004264_abnormal_extraembryonic_tissu2.18463365
26MP0003077_abnormal_cell_cycle2.08448557
27MP0003045_fibrosis2.04463993
28MP0003693_abnormal_embryo_hatching2.00963894
29MP0002254_reproductive_system_inflammat1.96238493
30MP0003183_abnormal_peptide_metabolism1.91512069
31MP0003718_maternal_effect1.81866960
32MP0009780_abnormal_chondrocyte_physiolo1.79315863
33MP0010307_abnormal_tumor_latency1.76184537
34MP0002653_abnormal_ependyma_morphology1.74495693
35MP0001119_abnormal_female_reproductive1.68759098
36MP0003705_abnormal_hypodermis_morpholog1.66426885
37MP0008007_abnormal_cellular_replicative1.64060255
38MP0005075_abnormal_melanosome_morpholog1.63678138
39MP0004957_abnormal_blastocyst_morpholog1.62247316
40MP0005389_reproductive_system_phenotype1.61159760
41MP0002796_impaired_skin_barrier1.60633422
42MP0003646_muscle_fatigue1.60586980
43MP0010352_gastrointestinal_tract_polyps1.60338795
44MP0001661_extended_life_span1.58507861
45MP0003787_abnormal_imprinting1.43787271
46MP0003123_paternal_imprinting1.42824685
47MP0003890_abnormal_embryonic-extraembry1.40266422
48MP0002098_abnormal_vibrissa_morphology1.38765959
49MP0000377_abnormal_hair_follicle1.34750472
50MP0003699_abnormal_female_reproductive1.32810016
51MP0005451_abnormal_body_composition1.25429616
52MP0001849_ear_inflammation1.23864345
53MP0001730_embryonic_growth_arrest1.22532604
54MP0005647_abnormal_sex_gland1.21623666
55MP0005409_darkened_coat_color1.20907063
56MP0001346_abnormal_lacrimal_gland1.19961296
57MP0003937_abnormal_limbs/digits/tail_de1.08860002
58MP0000579_abnormal_nail_morphology1.05950998
59MP0002282_abnormal_trachea_morphology1.05903072
60MP0000537_abnormal_urethra_morphology1.04054817
61MP0000566_synostosis1.04004279
62MP0002168_other_aberrant_phenotype1.03649140
63MP0003878_abnormal_ear_physiology1.02620104
64MP0005377_hearing/vestibular/ear_phenot1.02620104
65MP0001919_abnormal_reproductive_system1.01841853
66MP0003121_genomic_imprinting1.00352051
67MP0002084_abnormal_developmental_patter0.96942900
68MP0000647_abnormal_sebaceous_gland0.96571117
69MP0002095_abnormal_skin_pigmentation0.95729489
70MP0003942_abnormal_urinary_system0.94805581
71MP0002085_abnormal_embryonic_tissue0.93858018
72MP0004084_abnormal_cardiac_muscle0.93132168
73MP0000350_abnormal_cell_proliferation0.92651340
74MP0003195_calcinosis0.92293857
75MP0004808_abnormal_hematopoietic_stem0.91707376
76MP0003941_abnormal_skin_development0.90806561
77MP0005380_embryogenesis_phenotype0.90663961
78MP0001672_abnormal_embryogenesis/_devel0.90663961
79MP0008932_abnormal_embryonic_tissue0.90392611
80MP0005501_abnormal_skin_physiology0.88317485
81MP0002138_abnormal_hepatobiliary_system0.88310272
82MP0000627_abnormal_mammary_gland0.88233858
83MP0005670_abnormal_white_adipose0.88010167
84MP0002075_abnormal_coat/hair_pigmentati0.86155887
85MP0005174_abnormal_tail_pigmentation0.85693272
86MP0009278_abnormal_bone_marrow0.85357087
87MP0001881_abnormal_mammary_gland0.84475870
88MP0003763_abnormal_thymus_physiology0.84065514
89MP0003115_abnormal_respiratory_system0.83277517
90MP0001879_abnormal_lymphatic_vessel0.83163468
91MP0001697_abnormal_embryo_size0.82041281
92MP0001915_intracranial_hemorrhage0.77589077
93MP0000703_abnormal_thymus_morphology0.76179045
94MP0004036_abnormal_muscle_relaxation0.75653240
95MP0003453_abnormal_keratinocyte_physiol0.74740773
96MP0003315_abnormal_perineum_morphology0.73937805
97MP0000313_abnormal_cell_death0.73734430
98MP0000470_abnormal_stomach_morphology0.71975294
99MP0004233_abnormal_muscle_weight0.71581278
100MP0003936_abnormal_reproductive_system0.71411767
101MP0002233_abnormal_nose_morphology0.71175381
102MP0005085_abnormal_gallbladder_physiolo0.70689688
103MP0005248_abnormal_Harderian_gland0.69942920
104MP0010771_integument_phenotype0.69942355
105MP0003861_abnormal_nervous_system0.69605098
106MP0002909_abnormal_adrenal_gland0.68756664
107MP0004272_abnormal_basement_membrane0.67555658
108MP0006072_abnormal_retinal_apoptosis0.66571827
109MP0002269_muscular_atrophy0.64659715
110MP0001216_abnormal_epidermal_layer0.64136428
111MP0008789_abnormal_olfactory_epithelium0.64038161
112MP0005365_abnormal_bile_salt0.63204730
113MP0001986_abnormal_taste_sensitivity0.62564929
114MP0003984_embryonic_growth_retardation0.62321655
115MP0005395_other_phenotype0.62079548
116MP0004197_abnormal_fetal_growth/weight/0.61993555
117MP0001186_pigmentation_phenotype0.61565165
118MP0002132_abnormal_respiratory_system0.61024568
119MP0002249_abnormal_larynx_morphology0.60678786
120MP0005083_abnormal_biliary_tract0.60172349
121MP0009703_decreased_birth_body0.59654677
122MP0000678_abnormal_parathyroid_gland0.58872565
123MP0002019_abnormal_tumor_incidence0.58584247
124MP0003943_abnormal_hepatobiliary_system0.58392651
125MP0002135_abnormal_kidney_morphology0.58158778
126MP0003935_abnormal_craniofacial_develop0.58112356
127MP0002088_abnormal_embryonic_growth/wei0.57699103
128MP0004782_abnormal_surfactant_physiolog0.57322269
129MP0000534_abnormal_ureter_morphology0.57139192
130MP0002080_prenatal_lethality0.56734424
131MP0002136_abnormal_kidney_physiology0.55874244
132MP0000462_abnormal_digestive_system0.54617648
133MP0000015_abnormal_ear_pigmentation0.54410628
134MP0002086_abnormal_extraembryonic_tissu0.53289873
135MP0005076_abnormal_cell_differentiation0.51427405
136MP0001784_abnormal_fluid_regulation0.51378921
137MP0005187_abnormal_penis_morphology0.51282957
138MP0000432_abnormal_head_morphology0.51166728
139MP0002092_abnormal_eye_morphology0.50708187
140MP0010030_abnormal_orbit_morphology0.49948353
141MP0003119_abnormal_digestive_system0.49856059
142MP0000569_abnormal_digit_pigmentation0.48920540
143MP0002116_abnormal_craniofacial_bone0.48744090
144MP0004134_abnormal_chest_morphology0.48645772
145MP0006292_abnormal_olfactory_placode0.48423022
146MP0000427_abnormal_hair_cycle0.44645109
147MP0005646_abnormal_pituitary_gland0.42401134
148MP0001188_hyperpigmentation0.41810329
149MP0005397_hematopoietic_system_phenotyp0.41501974

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)8.52365428
2Absent/shortened dynein arms (HP:0200106)7.56130639
3Dynein arm defect of respiratory motile cilia (HP:0012255)7.56130639
4Amelogenesis imperfecta (HP:0000705)6.18420296
5Abnormal respiratory motile cilium physiology (HP:0012261)5.74396715
6Mesangial abnormality (HP:0001966)5.24900448
7Rhinitis (HP:0012384)5.10658867
8Abnormal respiratory epithelium morphology (HP:0012253)5.10100994
9Abnormal respiratory motile cilium morphology (HP:0005938)5.10100994
10Infertility (HP:0000789)4.87213032
11Focal segmental glomerulosclerosis (HP:0000097)4.82274481
12Chronic bronchitis (HP:0004469)4.80994448
13Gonadotropin excess (HP:0000837)4.80730498
14Stage 5 chronic kidney disease (HP:0003774)4.51723296
15Azoospermia (HP:0000027)4.51307215
16Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.47685137
17Abnormal ciliary motility (HP:0012262)4.42146929
18Horizontal nystagmus (HP:0000666)4.39246077
19Pili torti (HP:0003777)4.31591456
20Abnormality of the lower motor neuron (HP:0002366)4.27589524
21Abnormal spermatogenesis (HP:0008669)4.25709837
22Tubular atrophy (HP:0000092)4.11673449
23Lip pit (HP:0100267)4.05776261
24Acanthocytosis (HP:0001927)3.73391413
25Fibular hypoplasia (HP:0003038)3.64853144
26Nephronophthisis (HP:0000090)3.64684643
27Congenital ichthyosiform erythroderma (HP:0007431)3.57199131
28Glomerulosclerosis (HP:0000096)3.54352376
29Hypoalbuminemia (HP:0003073)3.50679137
30Abnormal albumin level (HP:0012116)3.50679137
31Bronchiectasis (HP:0002110)3.46846767
32Nasal polyposis (HP:0100582)3.44427700
33Male infertility (HP:0003251)3.39240913
34Hyperkalemia (HP:0002153)3.25262648
35Focal motor seizures (HP:0011153)3.23716206
36Right ventricular cardiomyopathy (HP:0011663)3.17686998
37Facial hemangioma (HP:0000329)3.13893989
38Type I transferrin isoform profile (HP:0003642)3.12682691
39Hypoproteinemia (HP:0003075)3.08807518
40Shoulder girdle muscle weakness (HP:0003547)3.05510172
41Nephrotic syndrome (HP:0000100)2.96262456
42Overlapping toe (HP:0001845)2.94945366
43Impulsivity (HP:0100710)2.90840899
44Non-midline cleft lip (HP:0100335)2.88439094
45Abnormality of the renal medulla (HP:0100957)2.84206613
46Amyotrophic lateral sclerosis (HP:0007354)2.84199708
47Abnormality of the nasal mucosa (HP:0000433)2.82948808
48Hypoplasia of the capital femoral epiphysis (HP:0003090)2.74016815
49Concave nail (HP:0001598)2.73968218
50Truncal obesity (HP:0001956)2.71985244
51Degeneration of anterior horn cells (HP:0002398)2.71288945
52Abnormality of the anterior horn cell (HP:0006802)2.71288945
53Papillary thyroid carcinoma (HP:0002895)2.68956380
54Parakeratosis (HP:0001036)2.67280266
55Aplasia/Hypoplasia of the fibula (HP:0006492)2.65760671
56Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.64871779
57Abnormal protein N-linked glycosylation (HP:0012347)2.64871779
58Abnormal protein glycosylation (HP:0012346)2.64871779
59Abnormal glycosylation (HP:0012345)2.64871779
60Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.63124477
61Degeneration of the lateral corticospinal tracts (HP:0002314)2.63124477
6211 pairs of ribs (HP:0000878)2.59729595
63Capillary hemangiomas (HP:0005306)2.58891197
64Osteomalacia (HP:0002749)2.58417145
65Bronchitis (HP:0012387)2.56668727
66J-shaped sella turcica (HP:0002680)2.56556419
67Abnormality of the vocal cords (HP:0008777)2.49745808
68Abnormal hair laboratory examination (HP:0003328)2.46541984
69Nephroblastoma (Wilms tumor) (HP:0002667)2.45641138
70Hypoplastic labia majora (HP:0000059)2.39973438
71Abnormality of aromatic amino acid family metabolism (HP:0004338)2.38587543
72Chromsome breakage (HP:0040012)2.35516158
73Short ribs (HP:0000773)2.35403980
74Chromosomal breakage induced by crosslinking agents (HP:0003221)2.33842383
75Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.33568528
76Absent epiphyses (HP:0010577)2.33568528
77Nephritis (HP:0000123)2.33131872
78Type II lissencephaly (HP:0007260)2.30138941
79Upper motor neuron abnormality (HP:0002127)2.29918949
80Abnormality of the fingertips (HP:0001211)2.29734744
81Esophageal varix (HP:0002040)2.27737610
82Tubulointerstitial abnormality (HP:0001969)2.26140204
83Tubulointerstitial fibrosis (HP:0005576)2.23280145
84Embryonal renal neoplasm (HP:0011794)2.22962246
85Vertebral arch anomaly (HP:0008438)2.22447771
86B lymphocytopenia (HP:0010976)2.15445578
87Abnormality of B cell number (HP:0010975)2.15445578
88Subcapsular cataract (HP:0000523)2.14861930
89Colon cancer (HP:0003003)2.14368834
90Abnormality of the renal cortex (HP:0011035)2.12201584
91Sparse lateral eyebrow (HP:0005338)2.12067059
92Difficulty walking (HP:0002355)2.08907194
93Deformed sella turcica (HP:0002681)2.08758625
94T lymphocytopenia (HP:0005403)2.07676286
95Abnormality of the labia majora (HP:0012881)2.06944546
96Ectopic kidney (HP:0000086)2.06917215
97Postaxial foot polydactyly (HP:0001830)2.04846329
98Supernumerary spleens (HP:0009799)2.04621997
99Increased nuchal translucency (HP:0010880)2.04013905
100Hypoplasia of the thymus (HP:0000778)2.03595203
101Hypokinesia (HP:0002375)2.02356369
102Abnormality of the corticospinal tract (HP:0002492)2.00944499
103Oligodactyly (hands) (HP:0001180)1.97453008
104Enlarged penis (HP:0000040)1.96410135
105Impaired proprioception (HP:0010831)1.95034300
106Tubulointerstitial nephritis (HP:0001970)1.94593931
107Abnormality of macular pigmentation (HP:0008002)1.94289119
108Microglossia (HP:0000171)1.93868797
109Bilateral sensorineural hearing impairment (HP:0008619)1.91940198
110Glomerulonephritis (HP:0000099)1.91502442
111Peripheral hypomyelination (HP:0007182)1.91146137
112Medial flaring of the eyebrow (HP:0010747)1.91013011
113Abnormality of the shoulder girdle musculature (HP:0001435)1.90671761
114Shawl scrotum (HP:0000049)1.89168734
115Selective tooth agenesis (HP:0001592)1.88913880
116Facial cleft (HP:0002006)1.88804936
117Rectal prolapse (HP:0002035)1.88496561
118Abnormality of T cell number (HP:0011839)1.87755184
119Abnormality of monocarboxylic acid metabolism (HP:0010996)1.86287824
120Scotoma (HP:0000575)1.85505578
121Molar tooth sign on MRI (HP:0002419)1.85196156
122Abnormality of midbrain morphology (HP:0002418)1.85196156
123Tracheal stenosis (HP:0002777)1.83855547
124Proximal placement of thumb (HP:0009623)1.83496718
125Deep philtrum (HP:0002002)1.82199292
126Abnormality of chromosome stability (HP:0003220)1.82008337
127Recurrent otitis media (HP:0000403)1.81889375
128Arteriovenous malformation (HP:0100026)1.81641693
129Abnormality of the radial head (HP:0003995)1.80363917
130Aplasia/Hypoplasia of the uvula (HP:0010293)1.79543644
131Breast carcinoma (HP:0003002)1.78057479
132Abnormality of potassium homeostasis (HP:0011042)1.77903695
133Ridged nail (HP:0001807)1.76925618
134Proximal amyotrophy (HP:0007126)1.76835892
135Cone-rod dystrophy (HP:0000548)1.75810894
136Resting tremor (HP:0002322)1.75638342
137Short thumb (HP:0009778)1.74810577
138Septate vagina (HP:0001153)1.74431886
139Deviation of the thumb (HP:0009603)1.74281247
140Meckel diverticulum (HP:0002245)1.73848775
141Abnormal lung lobation (HP:0002101)1.73802330
142Short thorax (HP:0010306)1.71795081
143Metaphyseal cupping (HP:0003021)1.71526352
144Rimmed vacuoles (HP:0003805)1.71124343
145Metaphyseal dysplasia (HP:0100255)1.70946752
146Hypoplastic iliac wings (HP:0002866)1.70180568
147Scapular winging (HP:0003691)1.69365338
148Sloping forehead (HP:0000340)1.68509829
149Corneal erosion (HP:0200020)1.67829279
150Abnormality of the phalanges of the hallux (HP:0010057)1.66955612
151Thyroiditis (HP:0100646)1.66860682
152Menstrual irregularities (HP:0000858)1.66408577
153Dysmetric saccades (HP:0000641)1.65274853
154Severe visual impairment (HP:0001141)1.64790363
155Primary amenorrhea (HP:0000786)1.64458795
156Abnormality of the ileum (HP:0001549)1.64002874
157Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.63759699
158Woolly hair (HP:0002224)1.63420368
159Cerebellar dysplasia (HP:0007033)1.62698719
160True hermaphroditism (HP:0010459)1.61890151
161Ependymoma (HP:0002888)1.61113816
162Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.61013400
163Small intestinal stenosis (HP:0012848)1.60361478
164Duodenal stenosis (HP:0100867)1.60361478
165Bicornuate uterus (HP:0000813)1.60293211
166Volvulus (HP:0002580)1.60196149
167Nonprogressive disorder (HP:0003680)1.59619789
168Taurodontia (HP:0000679)1.59523375
169Heterotopia (HP:0002282)1.59342742
170Median cleft lip (HP:0000161)1.56855518
171Aplasia/Hypoplasia of the earlobes (HP:0009906)1.56381691
172Abnormality of the epiphysis of the femoral head (HP:0010574)1.56252602
173Abnormality of the preputium (HP:0100587)1.54946185
174Renal dysplasia (HP:0000110)1.53897156
175Sandal gap (HP:0001852)1.52218588
176Panhypogammaglobulinemia (HP:0003139)1.51748057
177Severe combined immunodeficiency (HP:0004430)1.51421662
178Oligodactyly (HP:0012165)1.50202973
179Aplasia/Hypoplasia of the tibia (HP:0005772)1.47776657

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK37.32469878
2PDK47.32469878
3PDK24.74776741
4CDC73.73862622
5MET3.56168301
6PRKD32.71430817
7CDK122.70389190
8NEK22.60970257
9WNK42.44167201
10PNCK2.26282062
11MAP2K22.06427439
12ACVR1B1.93083410
13ICK1.92579362
14MST1R1.81610542
15STK391.74910704
16TTK1.72834521
17PTK2B1.69584775
18CDK191.64451370
19TRIB31.63951079
20PLK41.61162274
21NEK61.60539031
22ZAK1.58177900
23TESK11.55936498
24STK38L1.48850592
25EPHA21.45413631
26MAP3K91.43174986
27MAP3K21.41828184
28STK31.41697235
29NLK1.36650663
30TAF11.35796678
31BMX1.35277506
32CHEK21.32067946
33SCYL21.29261094
34PRKCI1.28900975
35CHEK11.27629407
36WEE11.20647775
37ATR1.18318185
38BUB11.18236230
39CSF1R1.17764059
40RET1.16188892
41PDPK11.15007135
42TYRO31.14602467
43KSR21.12184925
44PIK3CA1.10959813
45PLK11.09283927
46CCNB11.07755015
47RIPK11.03735625
48CDK30.97715523
49BRD40.94731362
50WNK10.94434296
51SIK10.92189599
52ATM0.92108175
53IRAK30.90971259
54PKN20.90397958
55WNK30.89229171
56STK380.89217477
57YES10.89020759
58MAP3K40.88857694
59LATS10.87447346
60NME10.87165009
61PAK40.86912440
62ARAF0.85513892
63PTK20.85368749
64MAP3K60.83784400
65SRPK10.82413715
66CASK0.81345371
67EPHB20.80640303
68RPS6KB20.80295109
69TAOK20.78400335
70AKT30.76977069
71EIF2AK30.73329027
72BRAF0.72971409
73SGK20.72205326
74OXSR10.67694682
75RPS6KB10.66941449
76PDGFRB0.65594308
77CDK70.65020942
78FRK0.64939928
79LATS20.63147312
80PLK30.62206548
81DYRK1B0.61714365
82CAMK1G0.60676723
83MAP2K10.58432073
84FGR0.55850565
85STK100.55107298
86MAPKAPK30.55058152
87CDK20.54702024
88MST40.51763928
89DYRK30.50839415
90MTOR0.50729675
91MELK0.50566628
92MKNK20.49456685
93CDK90.48479928
94SGK30.47757292
95CDK10.47423840
96MAP3K130.45985648
97PASK0.45206123
98CDK40.44749245
99MAP3K120.43596016
100AURKB0.42978293
101EEF2K0.40270416
102CSNK1G10.39702987
103PDK10.38383023
104GSK3B0.38093845
105PRKAA20.38034390
106DYRK1A0.37849140
107PRKD10.37770290
108FER0.37682178
109BMPR1B0.34268268
110CDK80.34178205
111MAP3K50.34117909
112AKT20.33204320
113TSSK60.33091826
114TNK20.32830508
115CSNK1D0.31519701
116PRKDC0.29578055
117CSNK1E0.29344215
118BMPR20.28892781
119AURKA0.27444881
120EIF2AK10.26440768
121PRKAA10.25132797
122NEK90.24988473
123MAPK70.24967760
124SGK2230.24655320
125SGK4940.24655320
126MAPK80.24319435
127PDGFRA0.23836588
128PBK0.23544513
129PLK20.22953443
130CSNK1A1L0.22742332
131MARK30.22042407
132CAMK1D0.21502577
133TXK0.21315103
134KSR10.21127681
135NTRK30.20886025
136MAP3K80.20531753
137MAPK10.20447443
138MUSK0.20370582
139TAOK10.20315172
140CHUK0.20288609
141MAP2K70.20035791
142NEK10.19959807
143PAK10.19441549
144MAPK90.19056997
145CSNK1G20.18392865
146AKT10.18360329
147PINK10.18130908
148CSNK1G30.16806740
149MAPK140.16421688
150MAP2K60.16041469
151PTK60.15621652
152MAP3K100.15427826
153MAPK30.11265656
154PRKCZ0.10329565
155TRIM280.08761741

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004005.04498197
2Basal transcription factors_Homo sapiens_hsa030223.98412682
3Dorso-ventral axis formation_Homo sapiens_hsa043203.62461233
4Fanconi anemia pathway_Homo sapiens_hsa034603.51197396
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.08118866
6Non-homologous end-joining_Homo sapiens_hsa034502.85720019
7Sphingolipid metabolism_Homo sapiens_hsa006002.85266396
8RNA transport_Homo sapiens_hsa030132.80777173
9Vitamin B6 metabolism_Homo sapiens_hsa007502.65122787
10mRNA surveillance pathway_Homo sapiens_hsa030152.63170644
11Cell cycle_Homo sapiens_hsa041102.60380017
12Oocyte meiosis_Homo sapiens_hsa041142.44368322
13Homologous recombination_Homo sapiens_hsa034402.40246818
14Phototransduction_Homo sapiens_hsa047442.22658098
15RNA degradation_Homo sapiens_hsa030182.05806674
16Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.96363066
17Phenylalanine metabolism_Homo sapiens_hsa003601.91682181
18Mismatch repair_Homo sapiens_hsa034301.85982426
19Spliceosome_Homo sapiens_hsa030401.81726182
20Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.79360978
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.73700378
22ABC transporters_Homo sapiens_hsa020101.63300480
23Selenocompound metabolism_Homo sapiens_hsa004501.60283192
24Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.53996225
25Pyruvate metabolism_Homo sapiens_hsa006201.51407138
26Nucleotide excision repair_Homo sapiens_hsa034201.48889785
27DNA replication_Homo sapiens_hsa030301.40952611
28Taste transduction_Homo sapiens_hsa047421.39934699
29Renin-angiotensin system_Homo sapiens_hsa046141.36111593
30Small cell lung cancer_Homo sapiens_hsa052221.35201238
31Glucagon signaling pathway_Homo sapiens_hsa049221.32139439
32Base excision repair_Homo sapiens_hsa034101.29986186
33alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.26960187
34Primary immunodeficiency_Homo sapiens_hsa053401.24142260
35Linoleic acid metabolism_Homo sapiens_hsa005911.19650122
36Antigen processing and presentation_Homo sapiens_hsa046121.15516345
37ECM-receptor interaction_Homo sapiens_hsa045121.15450344
38Ovarian steroidogenesis_Homo sapiens_hsa049131.05860225
39Axon guidance_Homo sapiens_hsa043601.03374714
40Circadian rhythm_Homo sapiens_hsa047101.03046465
41Lysine degradation_Homo sapiens_hsa003100.96149917
42p53 signaling pathway_Homo sapiens_hsa041150.95843534
43Long-term potentiation_Homo sapiens_hsa047200.95624080
44Sphingolipid signaling pathway_Homo sapiens_hsa040710.93924533
45Phosphatidylinositol signaling system_Homo sapiens_hsa040700.93054047
46T cell receptor signaling pathway_Homo sapiens_hsa046600.89449418
47Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.88120833
48Wnt signaling pathway_Homo sapiens_hsa043100.87964262
49N-Glycan biosynthesis_Homo sapiens_hsa005100.87221543
50RNA polymerase_Homo sapiens_hsa030200.86802962
51Purine metabolism_Homo sapiens_hsa002300.85368778
52Cysteine and methionine metabolism_Homo sapiens_hsa002700.85348742
53Glycerolipid metabolism_Homo sapiens_hsa005610.84776355
54Maturity onset diabetes of the young_Homo sapiens_hsa049500.83351039
55Glycerophospholipid metabolism_Homo sapiens_hsa005640.79305905
56Inositol phosphate metabolism_Homo sapiens_hsa005620.79294900
57Hippo signaling pathway_Homo sapiens_hsa043900.78122095
58Vitamin digestion and absorption_Homo sapiens_hsa049770.78097047
59HTLV-I infection_Homo sapiens_hsa051660.77894453
60Basal cell carcinoma_Homo sapiens_hsa052170.77729416
61Acute myeloid leukemia_Homo sapiens_hsa052210.77491174
62Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.74807798
63Endometrial cancer_Homo sapiens_hsa052130.73131057
64Estrogen signaling pathway_Homo sapiens_hsa049150.72951567
65Amphetamine addiction_Homo sapiens_hsa050310.70513211
66Hedgehog signaling pathway_Homo sapiens_hsa043400.70371879
67Renin secretion_Homo sapiens_hsa049240.69527537
68Huntingtons disease_Homo sapiens_hsa050160.69171647
69Adherens junction_Homo sapiens_hsa045200.69164335
70beta-Alanine metabolism_Homo sapiens_hsa004100.69054398
71Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.68031189
72One carbon pool by folate_Homo sapiens_hsa006700.67964724
73Tryptophan metabolism_Homo sapiens_hsa003800.67697355
74Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.67182211
75Prostate cancer_Homo sapiens_hsa052150.67055051
76Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.65780191
77mTOR signaling pathway_Homo sapiens_hsa041500.65451728
78Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.64938105
79Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.64816495
80TGF-beta signaling pathway_Homo sapiens_hsa043500.64356403
81Fatty acid biosynthesis_Homo sapiens_hsa000610.64326645
82Protein digestion and absorption_Homo sapiens_hsa049740.63601848
83Thyroid hormone signaling pathway_Homo sapiens_hsa049190.62480605
84Renal cell carcinoma_Homo sapiens_hsa052110.61705104
85Thyroid cancer_Homo sapiens_hsa052160.61275781
86VEGF signaling pathway_Homo sapiens_hsa043700.60462190
87AMPK signaling pathway_Homo sapiens_hsa041520.60016303
88Nitrogen metabolism_Homo sapiens_hsa009100.59534495
89MicroRNAs in cancer_Homo sapiens_hsa052060.59013450
90Pyrimidine metabolism_Homo sapiens_hsa002400.58854193
91FoxO signaling pathway_Homo sapiens_hsa040680.58340461
92Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.58327005
93Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.57957084
94Sulfur relay system_Homo sapiens_hsa041220.57710091
95Non-small cell lung cancer_Homo sapiens_hsa052230.55675474
96cGMP-PKG signaling pathway_Homo sapiens_hsa040220.54960095
97Ether lipid metabolism_Homo sapiens_hsa005650.53631117
98Epstein-Barr virus infection_Homo sapiens_hsa051690.53315609
99Prolactin signaling pathway_Homo sapiens_hsa049170.53109901
100Colorectal cancer_Homo sapiens_hsa052100.52152905
101Fatty acid elongation_Homo sapiens_hsa000620.51422454
102Viral carcinogenesis_Homo sapiens_hsa052030.50871599
103Herpes simplex infection_Homo sapiens_hsa051680.50829094
104Propanoate metabolism_Homo sapiens_hsa006400.49897135
105Focal adhesion_Homo sapiens_hsa045100.49461842
106Chronic myeloid leukemia_Homo sapiens_hsa052200.48672727
107Amoebiasis_Homo sapiens_hsa051460.48548231
108Tyrosine metabolism_Homo sapiens_hsa003500.48046421
109Pathways in cancer_Homo sapiens_hsa052000.46474387
110Histidine metabolism_Homo sapiens_hsa003400.46270302
111Tight junction_Homo sapiens_hsa045300.45659966
112Pentose phosphate pathway_Homo sapiens_hsa000300.44715075
113AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.44246973
114Pancreatic cancer_Homo sapiens_hsa052120.43177019
115ErbB signaling pathway_Homo sapiens_hsa040120.42488196
116Morphine addiction_Homo sapiens_hsa050320.42405970
117Insulin signaling pathway_Homo sapiens_hsa049100.40941246
118Steroid hormone biosynthesis_Homo sapiens_hsa001400.39485872
119Vascular smooth muscle contraction_Homo sapiens_hsa042700.39209454
120Olfactory transduction_Homo sapiens_hsa047400.39048698
121Fatty acid metabolism_Homo sapiens_hsa012120.39006253
122Nicotine addiction_Homo sapiens_hsa050330.38141810
123Regulation of autophagy_Homo sapiens_hsa041400.38044404
124Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.37769443
125Proteasome_Homo sapiens_hsa030500.37608184
126Gap junction_Homo sapiens_hsa045400.37044443
127Type II diabetes mellitus_Homo sapiens_hsa049300.35952075
128Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.35592022
129Aldosterone synthesis and secretion_Homo sapiens_hsa049250.35438036
130Longevity regulating pathway - mammal_Homo sapiens_hsa042110.35294886
131Collecting duct acid secretion_Homo sapiens_hsa049660.35078743
132Calcium signaling pathway_Homo sapiens_hsa040200.34315961
133Central carbon metabolism in cancer_Homo sapiens_hsa052300.33722919
134Ras signaling pathway_Homo sapiens_hsa040140.33354052
135Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.32951265
136Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.31548185
137Glioma_Homo sapiens_hsa052140.31543330
138Melanogenesis_Homo sapiens_hsa049160.30882716
139Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.29934521
140Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.29844361
141Choline metabolism in cancer_Homo sapiens_hsa052310.29339371
142Influenza A_Homo sapiens_hsa051640.29207376
143Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.29147702

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