TDRD6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a tudor domain-containing protein and component of the chromatoid body, a type of ribonucleoprotein granule present in male germ cells. Studies in rodents have demonstrated a role for the encoded protein in spermiogenesis and the nonsense mediated decay (NMD) pathway. This protein is a major autoantigen in human patients with autoimmune polyendocrine syndrome type 1 (APS1). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1plasma membrane fusion (GO:0045026)9.96711274
2cell-cell recognition (GO:0009988)9.77978334
3cilium movement (GO:0003341)9.40255260
4motile cilium assembly (GO:0044458)9.36823230
5epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)9.12889831
6spermatid development (GO:0007286)9.02468083
7reproduction (GO:0000003)8.82056286
8cell wall macromolecule metabolic process (GO:0044036)8.70636099
9cell wall macromolecule catabolic process (GO:0016998)8.70636099
10male meiosis (GO:0007140)8.56908308
11regulation of cilium movement (GO:0003352)8.56352276
12DNA synthesis involved in DNA repair (GO:0000731)8.50536910
13synaptonemal complex organization (GO:0070193)7.97141723
14synaptonemal complex assembly (GO:0007130)7.71433112
15sperm capacitation (GO:0048240)7.47442487
16single fertilization (GO:0007338)7.45132135
17fertilization (GO:0009566)6.40426449
18DNA methylation involved in gamete generation (GO:0043046)6.26681251
19male meiosis I (GO:0007141)6.06230772
20ventricular system development (GO:0021591)6.03545585
21oligosaccharide catabolic process (GO:0009313)5.82245388
22* spermatogenesis (GO:0007283)5.68462818
23negative regulation of inclusion body assembly (GO:0090084)5.68206586
24glycosphingolipid catabolic process (GO:0046479)5.66649170
25* male gamete generation (GO:0048232)5.66397754
26chromosome organization involved in meiosis (GO:0070192)5.34620761
27* gamete generation (GO:0007276)5.19919288
28* cellular process involved in reproduction in multicellular organism (GO:0022412)5.14308304
29seminiferous tubule development (GO:0072520)5.12749437
30organic cation transport (GO:0015695)5.12399354
31regulation of microtubule-based movement (GO:0060632)5.12106666
32glycolipid catabolic process (GO:0019377)5.07129524
33meiotic nuclear division (GO:0007126)5.05821906
34* germ cell development (GO:0007281)5.03394354
35cellular response to thyroid hormone stimulus (GO:0097067)5.00717522
36microtubule depolymerization (GO:0007019)4.95348834
37meiosis I (GO:0007127)4.90579038
38female gamete generation (GO:0007292)4.86968268
39meiotic cell cycle (GO:0051321)4.85027984
40left/right pattern formation (GO:0060972)4.81140294
41cell recognition (GO:0008037)4.73168321
42protein localization to cilium (GO:0061512)4.71123789
43microtubule severing (GO:0051013)4.70507979
44histone H3-K9 demethylation (GO:0033169)4.68640078
45calcium ion-dependent exocytosis (GO:0017156)4.67991529
46regulation of inclusion body assembly (GO:0090083)4.67537221
47ceramide catabolic process (GO:0046514)4.53658637
48sister chromatid cohesion (GO:0007062)4.49184779
49genitalia morphogenesis (GO:0035112)4.35106087
50monoubiquitinated protein deubiquitination (GO:0035520)4.28950648
51gene silencing by RNA (GO:0031047)4.11979466
52* multicellular organismal reproductive process (GO:0048609)4.10101189
53protein polyglutamylation (GO:0018095)4.00845973
54negative regulation of organelle assembly (GO:1902116)3.99460431
55amino sugar catabolic process (GO:0046348)3.91655028
56intraciliary transport (GO:0042073)3.90901960
57regulation of cholesterol storage (GO:0010885)3.89590405
58reciprocal DNA recombination (GO:0035825)3.89089976
59reciprocal meiotic recombination (GO:0007131)3.89089976
60histone H3-K36 demethylation (GO:0070544)3.76181193
61microtubule-based movement (GO:0007018)3.75176697
62positive regulation of monocyte chemotaxis (GO:0090026)3.72152243
63axoneme assembly (GO:0035082)3.71553492
64negative regulation of interleukin-12 production (GO:0032695)3.70518259
65oogenesis (GO:0048477)3.66924970
66regulation of centriole replication (GO:0046599)3.59578078
67positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.53248567
68response to thyroid hormone (GO:0097066)3.47697934
69regulation of mononuclear cell migration (GO:0071675)3.46055485
70chaperone-mediated protein complex assembly (GO:0051131)3.45745884
71fat-soluble vitamin biosynthetic process (GO:0042362)3.36398384
72vitamin D metabolic process (GO:0042359)3.34189483
73carnitine transport (GO:0015879)3.33583245
74amino-acid betaine transport (GO:0015838)3.33583245
75positive regulation of cellular amide metabolic process (GO:0034250)3.32004014
76carnitine transmembrane transport (GO:1902603)3.31486839
77positive regulation of leukocyte degranulation (GO:0043302)3.31276538
78* multicellular organismal development (GO:0007275)3.29098588
79positive regulation of meiosis (GO:0045836)3.28930966
80membrane lipid catabolic process (GO:0046466)3.27498205
81lactate metabolic process (GO:0006089)3.24759978
82response to peptidoglycan (GO:0032494)3.24471611
83DNA methylation (GO:0006306)3.23700660
84DNA alkylation (GO:0006305)3.23700660
85meiotic cell cycle process (GO:1903046)3.23620116
86regulation of meiosis I (GO:0060631)3.19824406
87alditol metabolic process (GO:0019400)3.19147019
88regulation of protein polyubiquitination (GO:1902914)3.18283835
89cilium organization (GO:0044782)3.16286195
90glycerol ether metabolic process (GO:0006662)3.15023648
91nuclear pore complex assembly (GO:0051292)3.11833686
92sphingolipid catabolic process (GO:0030149)3.11558063
93regulation of meiotic cell cycle (GO:0051445)3.10828813
94resolution of meiotic recombination intermediates (GO:0000712)3.08598762
95positive regulation of mast cell activation (GO:0033005)3.07795358
96positive regulation of meiotic cell cycle (GO:0051446)3.04946825
97synapsis (GO:0007129)3.03055767
98neutrophil activation involved in immune response (GO:0002283)3.02920041
99nucleoside diphosphate phosphorylation (GO:0006165)3.01424224
100cilium assembly (GO:0042384)3.01374088
101cilium morphogenesis (GO:0060271)2.97402378
102spermatid nucleus differentiation (GO:0007289)2.96926259
103peptidyl-glutamic acid modification (GO:0018200)2.95786880
104regulation of spindle checkpoint (GO:0090231)2.92738278
105ether metabolic process (GO:0018904)2.90177549
106positive regulation of mast cell degranulation (GO:0043306)2.90026246
107positive regulation of mast cell activation involved in immune response (GO:0033008)2.90026246
108regulation of vitamin D biosynthetic process (GO:0060556)2.89456347
109cellular component assembly involved in morphogenesis (GO:0010927)2.89388408
110negative regulation of DNA repair (GO:0045738)2.89279836
111DNA packaging (GO:0006323)2.89010346
112mitotic sister chromatid cohesion (GO:0007064)2.88602493
113protein refolding (GO:0042026)2.87767398
114chromosome condensation (GO:0030261)2.86839806
115centriole replication (GO:0007099)2.86815797
116polyol catabolic process (GO:0046174)2.86185633
117glycerol metabolic process (GO:0006071)2.85032518
118retinal cone cell development (GO:0046549)2.84420735
119ganglioside metabolic process (GO:0001573)2.83012619
120histone lysine demethylation (GO:0070076)2.82751628
121gene silencing (GO:0016458)2.81160380
122negative regulation of lipid storage (GO:0010888)2.75351989
123centriole assembly (GO:0098534)2.74931356
124low-density lipoprotein particle remodeling (GO:0034374)2.72875247
125histone demethylation (GO:0016577)2.70850821
126regulation of mast cell degranulation (GO:0043304)2.70576768
127regulation of monocyte chemotaxis (GO:0090025)2.70095599
128protein localization to chromosome (GO:0034502)2.68665659
129superoxide anion generation (GO:0042554)2.68050617
130detection of molecule of bacterial origin (GO:0032490)2.65207802
131positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.63890893
132regulation of macrophage chemotaxis (GO:0010758)2.61929320
133negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.61922964
134hydrogen peroxide biosynthetic process (GO:0050665)2.61605630
135prostate gland growth (GO:0060736)2.61233678
136glycolytic process (GO:0006096)2.60966206
137apoptotic cell clearance (GO:0043277)2.60428336
138sex differentiation (GO:0007548)2.60007703
139positive regulation of bone resorption (GO:0045780)2.59563315
140positive regulation of bone remodeling (GO:0046852)2.59563315
141nucleus organization (GO:0006997)2.58458056
142regulation of mast cell activation involved in immune response (GO:0033006)2.58353740
143osteoclast differentiation (GO:0030316)2.56765142
144negative regulation of NF-kappaB import into nucleus (GO:0042347)2.56350820
145positive regulation of cholesterol efflux (GO:0010875)2.55779683
146macrophage activation involved in immune response (GO:0002281)2.55585655
147positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.54465528
148microtubule polymerization or depolymerization (GO:0031109)2.54433098
149regulation of mast cell activation (GO:0033003)2.54421799
150N-acetylneuraminate metabolic process (GO:0006054)2.54005159
151regulation of leukocyte degranulation (GO:0043300)2.53739832
152positive regulation of toll-like receptor signaling pathway (GO:0034123)2.52296282
153GTP biosynthetic process (GO:0006183)2.49357795
154lipopolysaccharide-mediated signaling pathway (GO:0031663)2.48762745
155regulation of histone H3-K9 methylation (GO:0051570)2.47373127
156T-helper 1 type immune response (GO:0042088)2.46338888
157protein K11-linked deubiquitination (GO:0035871)2.46290396
158response to acidic pH (GO:0010447)2.45340326
159lipid storage (GO:0019915)2.41818115
160regulation of monocyte differentiation (GO:0045655)2.41392657
161nuclear pore organization (GO:0006999)2.41157176
162regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.40180687
163regulation of meiosis (GO:0040020)2.39408346
164protein demethylation (GO:0006482)2.36560154
165protein dealkylation (GO:0008214)2.36560154
166negative regulation of type I interferon production (GO:0032480)2.36480062
167regulation of DNA methylation (GO:0044030)2.35248390
168phagosome maturation (GO:0090382)2.33834050
169cilium or flagellum-dependent cell motility (GO:0001539)17.1388710
170fusion of sperm to egg plasma membrane (GO:0007342)13.0900300
171sperm motility (GO:0030317)12.1711153
172axonemal dynein complex assembly (GO:0070286)11.2053797
173sperm-egg recognition (GO:0035036)10.9379346
174multicellular organism reproduction (GO:0032504)10.8846633
175piRNA metabolic process (GO:0034587)10.7888250
176epithelial cilium movement (GO:0003351)10.5662055
177acrosome assembly (GO:0001675)10.4354072
178acrosome reaction (GO:0007340)10.4026930
179binding of sperm to zona pellucida (GO:0007339)10.0375241

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.85684116
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.26761158
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.85022102
4IRF8_21731497_ChIP-ChIP_J774_Mouse4.71125037
5IRF8_27001747_Chip-Seq_BMDM_Mouse4.03210569
6Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.73424008
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.40494971
8IRF8_22096565_ChIP-ChIP_GC-B_Human3.35710483
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.25050619
10NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.55107102
11PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.44258564
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.42820505
13* VDR_24787735_ChIP-Seq_THP-1_Human2.40895476
14ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.32070649
15CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.22927416
16MYB_21317192_ChIP-Seq_ERMYB_Mouse2.22635445
17CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.17543450
18FLI1_27457419_Chip-Seq_LIVER_Mouse2.14029020
19TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.09328650
20KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.07014665
21KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.07014665
22KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.07014665
23EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.03234597
24MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse11.5210532
25ZNF274_21170338_ChIP-Seq_K562_Hela1.96978085
26VDR_22108803_ChIP-Seq_LS180_Human1.90128405
27GATA1_26923725_Chip-Seq_HPCs_Mouse1.89271210
28POU3F2_20337985_ChIP-ChIP_501MEL_Human1.88000570
29ELK4_26923725_Chip-Seq_MESODERM_Mouse1.85412704
30PCGF2_27294783_Chip-Seq_ESCs_Mouse1.84402073
31STAT6_21828071_ChIP-Seq_BEAS2B_Human1.79063043
32NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.76215576
33IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.71387740
34IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.64668615
35GATA1_22025678_ChIP-Seq_K562_Human1.63797487
36VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.62893903
37CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.62753546
38SMAD_19615063_ChIP-ChIP_OVARY_Human1.61058363
39IGF1R_20145208_ChIP-Seq_DFB_Human1.60467473
40TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.60148526
41WDR5_24793694_ChIP-Seq_LNCAP_Human1.57467223
42STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.55199952
43STAT1_17558387_ChIP-Seq_HELA_Human1.53129656
44MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.51788823
45CBP_20019798_ChIP-Seq_JUKART_Human1.49593612
46IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.49593612
47NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.48638623
48FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46831030
49GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.44539724
50PCGF2_27294783_Chip-Seq_NPCs_Mouse1.43557155
51KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.42280622
52BCAT_22108803_ChIP-Seq_LS180_Human1.39318442
53CDX2_19796622_ChIP-Seq_MESCs_Mouse1.39315698
54RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.39041009
55PRDM14_20953172_ChIP-Seq_ESCs_Human1.38495684
56NFE2_27457419_Chip-Seq_LIVER_Mouse1.37057326
57AR_25329375_ChIP-Seq_VCAP_Human1.33040732
58UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.32964960
59STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.32917243
60BRD4_27068464_Chip-Seq_AML-cells_Mouse1.31801852
61TAL1_26923725_Chip-Seq_HPCs_Mouse1.30509014
62ER_23166858_ChIP-Seq_MCF-7_Human1.29447206
63MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.28543507
64SUZ12_27294783_Chip-Seq_NPCs_Mouse1.26160819
65TFEB_21752829_ChIP-Seq_HELA_Human1.25920044
66SOX2_22085726_ChIP-Seq_NPCs_Mouse1.25757554
67KAP1_22055183_ChIP-Seq_ESCs_Mouse1.25374180
68* REST_21632747_ChIP-Seq_MESCs_Mouse1.24687943
69KDM2B_26808549_Chip-Seq_REH_Human1.23961588
70RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.23162239
71STAT4_19710469_ChIP-ChIP_TH1__Mouse1.21255852
72GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18902727
73SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.18039074
74LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.16612298
75GATA3_21867929_ChIP-Seq_CD8_Mouse1.15833721
76POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.15407667
77TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15407667
78FLI1_21867929_ChIP-Seq_TH2_Mouse1.15397880
79TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.15106062
80AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.14206664
81TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.13546917
82FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.13322422
83* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.13122438
84FOXA1_21572438_ChIP-Seq_LNCaP_Human1.10618565
85PU_27001747_Chip-Seq_BMDM_Mouse1.09528265
86CBX2_27304074_Chip-Seq_ESCs_Mouse1.09426421
87ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.09302901
88SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.09266566
89P53_21459846_ChIP-Seq_SAOS-2_Human1.08612678
90SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07901459
91RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07511706
92BMI1_23680149_ChIP-Seq_NPCS_Mouse1.07402213
93CRX_20693478_ChIP-Seq_RETINA_Mouse1.06483635
94SPI1_23127762_ChIP-Seq_K562_Human1.06255766
95FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.05924893
96SPI1_23547873_ChIP-Seq_NB4_Human1.05766568
97GATA3_21867929_ChIP-Seq_TH1_Mouse1.04667679
98CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04219632
99PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.03813830
100PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.03809531
101TP63_23658742_ChIP-Seq_EP156T_Human1.02277147
102* RAD21_21589869_ChIP-Seq_MESCs_Mouse1.01419337
103GATA1_19941827_ChIP-Seq_MEL86_Mouse1.01410007
104GF1_26923725_Chip-Seq_HPCs_Mouse1.01312754
105NOTCH1_21737748_ChIP-Seq_TLL_Human1.01295564
106CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00121296
107PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99805325
108P300_19829295_ChIP-Seq_ESCs_Human0.99761399
109* RUNX2_22187159_ChIP-Seq_PCA_Human0.98631715
110NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98307688
111RUNX1_26923725_Chip-Seq_HPCs_Mouse0.98099175
112RBPJ_22232070_ChIP-Seq_NCS_Mouse0.97571776
113EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.97309225
114SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96936777
115CTBP2_25329375_ChIP-Seq_LNCAP_Human0.96708881
116RUNX_20019798_ChIP-Seq_JUKART_Human0.96637995
117NANOG_18555785_Chip-Seq_ESCs_Mouse0.96609374
118TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96203127
119STAT3_23295773_ChIP-Seq_U87_Human0.96201048
120OCT4_18555785_Chip-Seq_ESCs_Mouse0.96179258
121CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.96059138
122MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.95421798
123EZH2_27294783_Chip-Seq_NPCs_Mouse0.94920283
124SOX2_21211035_ChIP-Seq_LN229_Human0.94191356
125ERG_20517297_ChIP-Seq_VCAP_Human0.93307668
126CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.92662521
127SMRT_27268052_Chip-Seq_Bcells_Human0.92550822
128OCT4_21477851_ChIP-Seq_ESCs_Mouse0.92510687
129RNF2_27304074_Chip-Seq_NSC_Mouse0.92486025
130EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.92122566
131YY1_22570637_ChIP-Seq_MALME-3M_Human0.91731939
132TOP2B_26459242_ChIP-Seq_MCF-7_Human0.91561135
133TCF4_23295773_ChIP-Seq_U87_Human0.91556828
134RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.91539949
135PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.90240533
136P53_22387025_ChIP-Seq_ESCs_Mouse0.90182077
137MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.87498612
138KLF4_18555785_Chip-Seq_ESCs_Mouse0.87158738
139MYC_27129775_Chip-Seq_CORNEA_Mouse0.87005769
140SMAD4_21741376_ChIP-Seq_EPCs_Human0.86888607
141PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.86549169
142P300_18555785_Chip-Seq_ESCs_Mouse0.86328196
143ESET_19884257_ChIP-Seq_ESCs_Mouse0.84776786
144SMAD4_21799915_ChIP-Seq_A2780_Human0.84693578
145SPI1_26923725_Chip-Seq_HPCs_Mouse0.84641968
146SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.84546164
147GBX2_23144817_ChIP-Seq_PC3_Human0.84359060
148SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.84217406
149EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.84185389
150ZFP57_27257070_Chip-Seq_ESCs_Mouse0.84099848
151EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.83474459
152ESRRB_18555785_Chip-Seq_ESCs_Mouse0.83434547
153CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.83403761
154NFYB_21822215_ChIP-Seq_K562_Human0.82168396
155PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.81866534
156STAT3_18555785_Chip-Seq_ESCs_Mouse0.81819997
157RARA_24833708_ChIP-Seq_LIVER_Mouse0.81750121
158HTT_18923047_ChIP-ChIP_STHdh_Human0.80961016
159FOXA1_25329375_ChIP-Seq_VCAP_Human0.80045575
160FOXA1_27270436_Chip-Seq_PROSTATE_Human0.80045575
161CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.80009087
162GATA3_26560356_Chip-Seq_TH1_Human0.79376814
163CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.79228944
164FOXH1_21741376_ChIP-Seq_EPCs_Human0.78968261
165CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.77747464
166TCF4_22108803_ChIP-Seq_LS180_Human0.77268591
167GATA3_27048872_Chip-Seq_THYMUS_Human0.77244663
168FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.77180659
169SMAD3_21741376_ChIP-Seq_EPCs_Human0.76964428

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0003698_abnormal_male_reproductive5.89989496
2* MP0001929_abnormal_gametogenesis5.34609346
3MP0008877_abnormal_DNA_methylation4.89713292
4MP0005058_abnormal_lysosome_morphology4.54221534
5MP0002653_abnormal_ependyma_morphology4.04458504
6* MP0002210_abnormal_sex_determination3.58867341
7MP0009840_abnormal_foam_cell3.28871827
8MP0006082_CNS_inflammation3.21607795
9* MP0002161_abnormal_fertility/fecundity3.18631397
10* MP0001145_abnormal_male_reproductive3.04005515
11MP0003303_peritoneal_inflammation2.99054015
12MP0005623_abnormal_meninges_morphology2.91947459
13* MP0000653_abnormal_sex_gland2.62754014
14MP0000383_abnormal_hair_follicle2.60353380
15MP0003172_abnormal_lysosome_physiology2.54982032
16MP0003191_abnormal_cellular_cholesterol2.50312416
17MP0005310_abnormal_salivary_gland2.44564041
18MP0010678_abnormal_skin_adnexa2.41679812
19MP0003690_abnormal_glial_cell2.35267241
20MP0008004_abnormal_stomach_pH2.33461218
21MP0002148_abnormal_hypersensitivity_rea2.14293532
22MP0002160_abnormal_reproductive_system2.02989235
23MP0002419_abnormal_innate_immunity2.01674284
24MP0005410_abnormal_fertilization15.4886896
25MP0005451_abnormal_body_composition1.96079621
26MP0003724_increased_susceptibility_to1.95767481
27MP0003183_abnormal_peptide_metabolism1.92428093
28MP0003718_maternal_effect1.83814956
29MP0000343_altered_response_to1.76330747
30MP0005671_abnormal_response_to1.76222475
31MP0005670_abnormal_white_adipose1.72207618
32MP0001835_abnormal_antigen_presentation1.71570373
33MP0002282_abnormal_trachea_morphology1.71380724
34MP0003646_muscle_fatigue1.54625800
35MP0002998_abnormal_bone_remodeling1.51390446
36MP0005167_abnormal_blood-brain_barrier1.51093532
37MP0002452_abnormal_antigen_presenting1.49016564
38MP0009785_altered_susceptibility_to1.47257923
39MP0008057_abnormal_DNA_replication1.43175596
40MP0003436_decreased_susceptibility_to1.37748036
41MP0001790_abnormal_immune_system1.34837096
42MP0005387_immune_system_phenotype1.34837096
43MP0009046_muscle_twitch1.33834386
44MP0005365_abnormal_bile_salt1.32947535
45MP0002090_abnormal_vision1.31548790
46MP0003075_altered_response_to1.29856060
47MP0005000_abnormal_immune_tolerance1.28331343
48MP0002723_abnormal_immune_serum1.27990865
49MP0005025_abnormal_response_to1.25327031
50MP0000920_abnormal_myelination1.24809306
51MP0003195_calcinosis1.23551670
52MP0001853_heart_inflammation1.21293270
53MP0010234_abnormal_vibrissa_follicle1.19836385
54MP0009764_decreased_sensitivity_to1.15109353
55MP0008058_abnormal_DNA_repair1.14255028
56MP0004947_skin_inflammation1.13612062
57MP0000685_abnormal_immune_system1.12829520
58MP0005647_abnormal_sex_gland1.12012499
59MP0010386_abnormal_urinary_bladder1.11827111
60MP0001501_abnormal_sleep_pattern1.09201770
61MP0003453_abnormal_keratinocyte_physiol1.08430244
62MP0004233_abnormal_muscle_weight1.08235487
63MP0000427_abnormal_hair_cycle1.07535435
64MP0010094_abnormal_chromosome_stability1.07446127
65MP0008995_early_reproductive_senescence1.07236429
66MP0001800_abnormal_humoral_immune1.07115802
67MP0003448_altered_tumor_morphology1.05082303
68MP0000015_abnormal_ear_pigmentation1.03577194
69MP0005389_reproductive_system_phenotype1.00800252
70MP0002420_abnormal_adaptive_immunity1.00313977
71MP0001845_abnormal_inflammatory_respons0.99907933
72MP0001819_abnormal_immune_cell0.99493066
73MP0003656_abnormal_erythrocyte_physiolo0.97873498
74MP0005257_abnormal_intraocular_pressure0.97060835
75MP0000569_abnormal_digit_pigmentation0.96927141
76MP0005464_abnormal_platelet_physiology0.96790423
77MP0001765_abnormal_ion_homeostasis0.96179218
78MP0008469_abnormal_protein_level0.92499375
79MP0003632_abnormal_nervous_system0.91787939
80MP0004742_abnormal_vestibular_system0.89022055
81MP0000371_diluted_coat_color0.88390977
82MP0005166_decreased_susceptibility_to0.87213047
83MP0001984_abnormal_olfaction0.86241600
84MP0005646_abnormal_pituitary_gland0.85212801
85MP0008007_abnormal_cellular_replicative0.83856811
86MP0003011_delayed_dark_adaptation0.83436223
87MP0003950_abnormal_plasma_membrane0.82374582
88MP0003300_gastrointestinal_ulcer0.80943424
89MP0002095_abnormal_skin_pigmentation0.79770467
90MP0002254_reproductive_system_inflammat0.78803415
91MP0005174_abnormal_tail_pigmentation0.74304032
92MP0008260_abnormal_autophagy0.73668015
93MP0001533_abnormal_skeleton_physiology0.73506049
94MP0005395_other_phenotype0.72385893
95MP0003878_abnormal_ear_physiology0.71669230
96MP0005377_hearing/vestibular/ear_phenot0.71669230
97MP0003786_premature_aging0.71563578
98MP0005397_hematopoietic_system_phenotyp0.64062074
99MP0001545_abnormal_hematopoietic_system0.64062074
100MP0003329_amyloid_beta_deposits0.62741588
101MP0003115_abnormal_respiratory_system0.62436858
102MP0009278_abnormal_bone_marrow0.61861359
103MP0003111_abnormal_nucleus_morphology0.52806547
104MP0004808_abnormal_hematopoietic_stem0.50660922
105MP0004134_abnormal_chest_morphology0.50525525
106MP0002928_abnormal_bile_duct0.48247262
107MP0003699_abnormal_female_reproductive0.47360898
108MP0005636_abnormal_mineral_homeostasis0.46703933
109MP0001293_anophthalmia0.46280058
110MP0005666_abnormal_adipose_tissue0.44272212
111MP0010307_abnormal_tumor_latency0.41901092
112MP0002234_abnormal_pharynx_morphology0.41275641
113MP0001324_abnormal_eye_pigmentation0.40912365
114MP0000751_myopathy0.39536604
115MP0004036_abnormal_muscle_relaxation0.38927881
116MP0001730_embryonic_growth_arrest0.37759557
117MP0002971_abnormal_brown_adipose0.36857961
118MP0005551_abnormal_eye_electrophysiolog0.36429166
119MP0005253_abnormal_eye_physiology0.35640743
120MP0005391_vision/eye_phenotype0.35457445
121MP0001119_abnormal_female_reproductive0.34734473
122MP0001661_extended_life_span0.33794703
123MP0004019_abnormal_vitamin_homeostasis0.33477505
124MP0002269_muscular_atrophy0.33291934
125MP0003045_fibrosis0.33129684
126MP0000604_amyloidosis0.30801660
127MP0008961_abnormal_basal_metabolism0.30569838
128* MP0000358_abnormal_cell_content/0.30189222
129MP0004811_abnormal_neuron_physiology0.29960358
130MP0002152_abnormal_brain_morphology0.29507236
131MP0003861_abnormal_nervous_system0.29473969
132MP0003879_abnormal_hair_cell0.29448132
133MP0001727_abnormal_embryo_implantation0.29167623
134MP0002092_abnormal_eye_morphology0.27836674
135MP0003633_abnormal_nervous_system0.27744427
136MP0001851_eye_inflammation0.27234267
137MP0000313_abnormal_cell_death0.26881323
138MP0009115_abnormal_fat_cell0.25607766
139MP0006036_abnormal_mitochondrial_physio0.24645226
140MP0002084_abnormal_developmental_patter0.23986231
141MP0003077_abnormal_cell_cycle0.23834531
142MP0003631_nervous_system_phenotype0.23681141
143MP0004270_analgesia0.21911556
144MP0006138_congestive_heart_failure0.21794238
145MP0002108_abnormal_muscle_morphology0.21333045
146MP0004264_abnormal_extraembryonic_tissu0.20802088
147MP0002796_impaired_skin_barrier0.20770502
148MP0002229_neurodegeneration0.20664595
149MP0001764_abnormal_homeostasis0.20072976
150MP0004043_abnormal_pH_regulation0.19684005
151MP0002102_abnormal_ear_morphology0.18826959
152MP0005423_abnormal_somatic_nervous0.18445401
153MP0003942_abnormal_urinary_system0.17058470
154MP0001440_abnormal_grooming_behavior0.16766581
155MP0000534_abnormal_ureter_morphology0.16305991
156MP0002295_abnormal_pulmonary_circulatio0.16086780
157MP0004133_heterotaxia0.16045882
158MP0005076_abnormal_cell_differentiation0.15994703
159MP0003936_abnormal_reproductive_system0.15686998
160MP0000955_abnormal_spinal_cord0.15285114
161MP0002405_respiratory_system_inflammati0.15279105
162MP0001697_abnormal_embryo_size0.14652417
163MP0005380_embryogenesis_phenotype0.14647869
164MP0001672_abnormal_embryogenesis/_devel0.14647869
165MP0002139_abnormal_hepatobiliary_system0.14311500
166MP0006035_abnormal_mitochondrial_morpho0.14279113

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.39379954
2Abnormal respiratory motile cilium morphology (HP:0005938)8.93475555
3Abnormal respiratory epithelium morphology (HP:0012253)8.93475555
4Abnormality of glycolipid metabolism (HP:0010969)8.80100021
5Abnormality of liposaccharide metabolism (HP:0010968)8.80100021
6Abnormality of glycosphingolipid metabolism (HP:0004343)8.80100021
7Rhinitis (HP:0012384)8.13635670
8Abnormal ciliary motility (HP:0012262)7.66965980
9Chronic bronchitis (HP:0004469)6.95327130
10Nasal polyposis (HP:0100582)6.63226300
11Infertility (HP:0000789)6.54597669
12Vacuolated lymphocytes (HP:0001922)5.55038502
13Abnormality of the nasal mucosa (HP:0000433)5.45341399
14Disinhibition (HP:0000734)5.26475158
15Bronchiectasis (HP:0002110)4.79648817
16Bronchitis (HP:0012387)4.69518694
17Loss of speech (HP:0002371)4.65163770
18Nephronophthisis (HP:0000090)4.57539102
19Increased cerebral lipofuscin (HP:0011813)4.52660531
20Abnormality of macrophages (HP:0004311)4.49387851
21Oligodactyly (hands) (HP:0001180)4.08392796
22Inappropriate behavior (HP:0000719)3.81207260
23Dysostosis multiplex (HP:0000943)3.75141137
24Myocardial infarction (HP:0001658)3.62157883
25Shoulder girdle muscle weakness (HP:0003547)3.58768159
26Abnormality of the renal medulla (HP:0100957)3.54828687
27Recurrent bacterial skin infections (HP:0005406)3.54446017
28Apathy (HP:0000741)3.49091220
29Recurrent otitis media (HP:0000403)3.48812225
30Recurrent sinusitis (HP:0011108)3.41233305
31Diminished motivation (HP:0000745)3.33868645
32Gonadotropin excess (HP:0000837)3.25251179
33Male infertility (HP:0003251)3.24975428
34Mutism (HP:0002300)3.23706275
35Abnormality of the lower motor neuron (HP:0002366)3.22021488
36Eczematoid dermatitis (HP:0000976)3.20322074
37Recurrent gram-negative bacterial infections (HP:0005420)3.19979682
38Recurrent bronchitis (HP:0002837)3.18979737
39Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.17650368
40Abnormality of the vasculature of the conjunctiva (HP:0008054)3.12282050
41Recurrent abscess formation (HP:0002722)3.11905614
42Degeneration of the lateral corticospinal tracts (HP:0002314)3.11284408
43Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.11284408
44Abnormality of the periventricular white matter (HP:0002518)3.10933843
45Retinal atrophy (HP:0001105)3.05874814
46Tubulointerstitial nephritis (HP:0001970)3.05162576
47Agnosia (HP:0010524)3.04895132
48Increased neuronal autofluorescent lipopigment (HP:0002074)2.93516863
49Volvulus (HP:0002580)2.83033318
50Autoimmune thrombocytopenia (HP:0001973)2.79738893
51Abnormal spermatogenesis (HP:0008669)2.77875412
52Cerebral inclusion bodies (HP:0100314)2.74232982
53Rimmed vacuoles (HP:0003805)2.71574172
54Metaphyseal irregularity (HP:0003025)2.71552954
55Impulsivity (HP:0100710)2.67191638
56Neuronal loss in central nervous system (HP:0002529)2.65453516
57Mediastinal lymphadenopathy (HP:0100721)2.62488014
58Oligodactyly (HP:0012165)2.57221430
59Systemic lupus erythematosus (HP:0002725)2.56282212
60Mucopolysacchariduria (HP:0008155)2.55267064
61Urinary glycosaminoglycan excretion (HP:0003541)2.55267064
62Abnormality of polysaccharide metabolism (HP:0011012)2.55209240
63Abnormality of glycosaminoglycan metabolism (HP:0004371)2.55209240
64Abnormality of mucopolysaccharide metabolism (HP:0011020)2.55209240
65Amyotrophic lateral sclerosis (HP:0007354)2.54860913
66Dementia (HP:0000726)2.53245063
67Axonal loss (HP:0003447)2.51054165
68Atrophy/Degeneration involving motor neurons (HP:0007373)2.44912533
69Supranuclear gaze palsy (HP:0000605)2.42327111
70Fibular hypoplasia (HP:0003038)2.41230021
71Molar tooth sign on MRI (HP:0002419)2.37960785
72Abnormality of midbrain morphology (HP:0002418)2.37960785
73Tubulointerstitial abnormality (HP:0001969)2.37812150
74Tubular atrophy (HP:0000092)2.35878261
75Pili torti (HP:0003777)2.32597766
76Papillary thyroid carcinoma (HP:0002895)2.30872230
77Conjunctival telangiectasia (HP:0000524)2.28089349
78Absent frontal sinuses (HP:0002688)2.24752198
79Abnormality of the corticospinal tract (HP:0002492)2.24139343
80Fair hair (HP:0002286)2.23389795
81Spastic tetraparesis (HP:0001285)2.20541566
82Hypoplasia of the capital femoral epiphysis (HP:0003090)2.20179454
83Postaxial foot polydactyly (HP:0001830)2.14369827
84J-shaped sella turcica (HP:0002680)2.13104847
85Medial flaring of the eyebrow (HP:0010747)2.12488323
86Urinary bladder sphincter dysfunction (HP:0002839)2.12480825
87Nausea (HP:0002018)2.11965349
88Facial hemangioma (HP:0000329)2.10326143
89Azoospermia (HP:0000027)2.09085606
90Abnormality of the motor neurons (HP:0002450)2.06295371
91Abnormal neuron morphology (HP:0012757)2.06295371
92Impaired proprioception (HP:0010831)2.05974674
93Capillary hemangiomas (HP:0005306)2.04060507
94Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.7897198
95Absent/shortened dynein arms (HP:0200106)12.8146305
96Dynein arm defect of respiratory motile cilia (HP:0012255)12.8146305
97Urinary incontinence (HP:0000020)1.98669830
98Memory impairment (HP:0002354)1.97067825
99Stage 5 chronic kidney disease (HP:0003774)1.96256167
100Epidermoid cyst (HP:0200040)1.93995389
101Truncal obesity (HP:0001956)1.93918904
102Microglossia (HP:0000171)1.93720355
103Short ribs (HP:0000773)1.93580090
104Abnormality of the basal ganglia (HP:0002134)1.93390246
105Skin nodule (HP:0200036)1.93064293
106Action tremor (HP:0002345)1.92995465
107Prostate neoplasm (HP:0100787)1.87184954
108Cholecystitis (HP:0001082)1.86405601
109Abnormal gallbladder physiology (HP:0012438)1.86405601
110Spontaneous abortion (HP:0005268)1.84122692
111Urinary urgency (HP:0000012)1.83290988
112Global brain atrophy (HP:0002283)1.82716041
113Heterotopia (HP:0002282)1.82501026
114Esophageal neoplasm (HP:0100751)1.82205581
115Neoplasm of head and neck (HP:0012288)1.82205581
116Generalized hypopigmentation of hair (HP:0011358)1.81815450
117Congenital hepatic fibrosis (HP:0002612)1.80900416
118Nuclear cataract (HP:0100018)1.80800409
119Abnormality of dentin (HP:0010299)1.80046601
120Prolonged neonatal jaundice (HP:0006579)1.78488576
121Abnormality of the renal cortex (HP:0011035)1.78081262
122Asymmetric septal hypertrophy (HP:0001670)1.77652238
123Abnormality of permanent molar morphology (HP:0011071)1.77144373
124Abnormality of the dental root (HP:0006486)1.77144373
125Taurodontia (HP:0000679)1.77144373
126Renal dysplasia (HP:0000110)1.76384893
127Upper motor neuron abnormality (HP:0002127)1.75965565
128Abnormality of the lumbar spine (HP:0100712)1.75911828
129Absent epiphyses (HP:0010577)1.74131466
130Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.74131466
131Tubulointerstitial fibrosis (HP:0005576)1.73839363
132Hematochezia (HP:0002573)1.73659268
133Dysphonia (HP:0001618)1.72386635
134Supernumerary spleens (HP:0009799)1.71521262
135Hepatosplenomegaly (HP:0001433)1.71414061
136Xanthomatosis (HP:0000991)1.71059813
137Peripheral demyelination (HP:0011096)1.70910993
138Bell-shaped thorax (HP:0001591)1.70564968
139Abnormality of lateral ventricle (HP:0030047)1.70338202
140Protruding tongue (HP:0010808)1.69205360
141Widely spaced teeth (HP:0000687)1.68934979
142Progressive neurologic deterioration (HP:0002344)1.67282019
143Gingivitis (HP:0000230)1.66974217
144Resting tremor (HP:0002322)1.66547077
145Spastic gait (HP:0002064)1.66419115
146Polyneuropathy (HP:0001271)1.66108406
147Thoracic kyphosis (HP:0002942)1.65976448
148Oculomotor apraxia (HP:0000657)1.65784160
149Horizontal nystagmus (HP:0000666)1.65685006
150Abnormality of the thoracic spine (HP:0100711)1.64866743
151Abnormality of molar morphology (HP:0011070)1.64717424
152Abnormality of molar (HP:0011077)1.64717424
153Malnutrition (HP:0004395)1.64544465
154Retrobulbar optic neuritis (HP:0100654)1.63806181
155Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.63193104
156Abnormality of the dental pulp (HP:0006479)1.60393697
157Deformed sella turcica (HP:0002681)1.60146008
158Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.59375320
159Degeneration of anterior horn cells (HP:0002398)1.58709764
160Abnormality of the anterior horn cell (HP:0006802)1.58709764
161Abnormal drinking behavior (HP:0030082)1.58436172
162Polydipsia (HP:0001959)1.58436172
163Chronic sinusitis (HP:0011109)1.57879363
164Facial cleft (HP:0002006)1.51495570
165Short thorax (HP:0010306)1.51267430
166Postaxial hand polydactyly (HP:0001162)1.48975810
167Aplasia/Hypoplasia of the fibula (HP:0006492)1.48266444
168Bile duct proliferation (HP:0001408)1.47215170
169Abnormal biliary tract physiology (HP:0012439)1.47215170
170Broad distal phalanx of finger (HP:0009836)1.44896622
171Abnormality of renal excretion (HP:0011036)1.43631820
172Aplasia/Hypoplasia of the tongue (HP:0010295)1.40382033
173Cystic liver disease (HP:0006706)1.36358397
174Hemiparesis (HP:0001269)1.35778875
175Pachygyria (HP:0001302)1.35408310
176Dyschromatopsia (HP:0007641)1.33947711
177Median cleft lip (HP:0000161)1.33351045
178Nephropathy (HP:0000112)1.32481312
179Breast carcinoma (HP:0003002)1.31197378
180Decreased motor nerve conduction velocity (HP:0003431)1.30643301
181Short femoral neck (HP:0100864)1.27495074
18211 pairs of ribs (HP:0000878)1.24489290
183Neurofibrillary tangles (HP:0002185)1.20334899
184Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.19716981
185Pancreatic fibrosis (HP:0100732)1.18371180
186Choroideremia (HP:0001139)1.18127575
187Abnormality of the frontal sinuses (HP:0002687)1.18058770
188Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.17142694
189Abnormality of ocular smooth pursuit (HP:0000617)1.17004133
190Abnormality of the sella turcica (HP:0002679)1.15820736
191Hypoplasia of dental enamel (HP:0006297)1.14756245
192Short nail (HP:0001799)1.14580735
193Decreased central vision (HP:0007663)1.14538169

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.32302346
2PDK48.32302346
3PDK25.37501394
4TESK15.34207975
5PRKD34.45702023
6MAP3K133.76708994
7ACVR1B3.62605723
8ICK3.58644473
9PNCK3.25937812
10GRK73.04780429
11MAP3K93.01540969
12WNK42.82855606
13IRAK32.80528154
14STK392.71699267
15ARAF2.53757967
16MOS2.52600483
17PTK2B2.49071212
18CDK192.20588804
19FGR2.19957237
20NEK92.19454422
21NEK21.93227155
22MAP3K141.84774669
23TGFBR21.79685270
24BLK1.63926094
25CAMKK21.61349699
26STK381.51330171
27DDR21.46436246
28WNK11.41219122
29MAPK151.36243012
30MAP3K51.35921979
31MATK1.34225549
32TAOK31.31762159
33KSR21.24031115
34DYRK1B1.21165028
35PDGFRA1.21048516
36TYK21.18138977
37MET1.10215988
38TYRO31.08695043
39ADRBK21.01253911
40KSR11.00243407
41OXSR10.98225484
42PASK0.95205402
43CCNB10.94235726
44STK30.93497275
45BMPR20.92501720
46CAMK1G0.89357827
47RIPK10.88729159
48TBK10.87839881
49PDK10.87497899
50BMPR1B0.86977827
51STK240.81591028
52TAOK20.81082397
53DYRK30.77695610
54RAF10.76533820
55CAMK1D0.75277057
56MAP3K10.72613544
57CDC70.72560836
58WEE10.72415616
59TTK0.71268125
60IKBKE0.67953829
61IRAK40.65402414
62IKBKB0.64527921
63MAPK70.63813799
64CDC42BPA0.63630012
65MAP3K20.63094808
66IRAK10.58791321
67PINK10.58741583
68MAP3K30.57896952
69SGK10.57889898
70PRPF4B0.57526936
71TESK20.56592988
72CHEK10.55812073
73JAK20.54383346
74BMX0.54087626
75JAK30.54020794
76ATR0.52525058
77SGK20.50403052
78CHEK20.49436067
79LMTK20.48538021
80ABL20.47251816
81PLK20.44177425
82RET0.43711511
83AKT30.42763293
84MELK0.42484304
85MTOR0.42349142
86SGK30.42002084
87ATM0.41798905
88CAMK10.40981628
89FGFR30.40611161
90EEF2K0.39110892
91NME20.38354678
92NTRK30.38105748
93PIM10.36322159
94CAMK40.36233472
95NTRK20.35896721
96MAP2K30.35860327
97PDPK10.35697435
98PAK20.35011630
99PAK10.33721123
100PLK40.33256921
101MAP2K60.32516157
102IGF1R0.32328514
103CAMKK10.32023721
104CHUK0.30518599
105ABL10.29762471
106RPS6KA20.29657426
107CDK120.28457254
108LYN0.28185968
109LCK0.28167527
110SYK0.27961812
111MAPK120.26670026
112PRKAA10.26276544
113MAP3K110.25769738
114PLK10.25730408
115MARK20.25033524
116NEK60.23052704
117RPS6KB10.22720804
118MAPKAPK50.21561070
119PRKCG0.21238505
120IRAK20.20946235
121MUSK0.18847355
122RIPK40.15088327
123PAK60.15041414
124CSNK1D0.14967670
125MAP3K40.14815784
126WNK30.11418190
127STK38L0.10950790
128TAOK10.10861817
129CDK10.08823592
130PAK40.08791004
131PRKCQ0.07613861
132PRKACB0.07506844
133GSK3B0.07483215
134CDK20.07155145
135PRKDC0.05820688
136CDK150.05732667
137CDK30.05299889
138MAPK80.04989179
139STK110.04970168
140PRKG10.04885614
141EPHB10.04676640
142PRKACG0.04468555
143PRKCZ0.03778776
144CDK180.03224923
145CSNK2A10.03194642
146CDK11A0.02975639
147RPS6KA10.02595229
148PDGFRB0.02090399
149RPS6KA30.01822295
150EGFR0.01636318
151BRSK20.01288413
152PRKCB0.01019744
153CSNK2A20.00439865
154CDK140.00277896
155CAMK2A0.00127174
156PKN1-0.0331523
157CSNK1E-0.0330880
158BRAF-0.0330413
159CSF1R-0.0296997
160ZAP70-0.0248460
161STK10-0.0203153
162CDK6-0.0173441
163MAPK10-0.0111897
164MARK1-0.0095923
165MARK3-0.0090837
166MAP3K10-0.0040124
167CSK-0.0033997
168MAPK1-0.0018423

Predicted pathways (KEGG)

RankGene SetZ-score
1Lysosome_Homo sapiens_hsa041424.33567773
2Vitamin B6 metabolism_Homo sapiens_hsa007504.24141182
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.06323930
4Pyruvate metabolism_Homo sapiens_hsa006204.03699651
5Other glycan degradation_Homo sapiens_hsa005114.02279722
6Dorso-ventral axis formation_Homo sapiens_hsa043203.53064161
7Fatty acid biosynthesis_Homo sapiens_hsa000613.23847493
8Propanoate metabolism_Homo sapiens_hsa006403.13875969
9Glucagon signaling pathway_Homo sapiens_hsa049222.87041280
10Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.84390419
11Rheumatoid arthritis_Homo sapiens_hsa053232.78284790
12Osteoclast differentiation_Homo sapiens_hsa043802.58603719
13Selenocompound metabolism_Homo sapiens_hsa004502.52731876
14alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.49739388
15Toll-like receptor signaling pathway_Homo sapiens_hsa046202.40095177
16Fanconi anemia pathway_Homo sapiens_hsa034602.37364415
17Basal transcription factors_Homo sapiens_hsa030222.37011489
18Staphylococcus aureus infection_Homo sapiens_hsa051502.35136628
19Linoleic acid metabolism_Homo sapiens_hsa005912.34920287
20Huntingtons disease_Homo sapiens_hsa050162.27185262
21Pentose phosphate pathway_Homo sapiens_hsa000302.21539902
22Phagosome_Homo sapiens_hsa041452.21499083
23Leishmaniasis_Homo sapiens_hsa051402.17275578
24Oocyte meiosis_Homo sapiens_hsa041142.15792117
25Glycerolipid metabolism_Homo sapiens_hsa005611.99078883
26Tuberculosis_Homo sapiens_hsa051521.96217841
27Carbohydrate digestion and absorption_Homo sapiens_hsa049731.90935407
28Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.84933739
29Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.84012219
30Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.83597989
31PPAR signaling pathway_Homo sapiens_hsa033201.76514990
32Amphetamine addiction_Homo sapiens_hsa050311.74584190
33Asthma_Homo sapiens_hsa053101.71739903
34Primary bile acid biosynthesis_Homo sapiens_hsa001201.71067641
35Allograft rejection_Homo sapiens_hsa053301.63615879
36NOD-like receptor signaling pathway_Homo sapiens_hsa046211.58168722
37Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.57701455
38Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.57194508
39mRNA surveillance pathway_Homo sapiens_hsa030151.52436696
40Graft-versus-host disease_Homo sapiens_hsa053321.49330713
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.48123179
42Renin secretion_Homo sapiens_hsa049241.45223131
43Malaria_Homo sapiens_hsa051441.44870167
44TNF signaling pathway_Homo sapiens_hsa046681.43151875
45Fructose and mannose metabolism_Homo sapiens_hsa000511.39917579
46NF-kappa B signaling pathway_Homo sapiens_hsa040641.38474483
47Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.38414144
48Pertussis_Homo sapiens_hsa051331.37350766
49Cardiac muscle contraction_Homo sapiens_hsa042601.35714291
50Glycerophospholipid metabolism_Homo sapiens_hsa005641.35095612
51RNA transport_Homo sapiens_hsa030131.33116366
52Carbon metabolism_Homo sapiens_hsa012001.31453109
53Autoimmune thyroid disease_Homo sapiens_hsa053201.29935459
54Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.28899116
55Toxoplasmosis_Homo sapiens_hsa051451.27620168
56Glycosaminoglycan degradation_Homo sapiens_hsa005311.26338793
57Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.17878907
58Fatty acid metabolism_Homo sapiens_hsa012121.16995443
59Sphingolipid metabolism_Homo sapiens_hsa006001.15521452
60Type I diabetes mellitus_Homo sapiens_hsa049401.15209668
61Salmonella infection_Homo sapiens_hsa051321.14611082
62Intestinal immune network for IgA production_Homo sapiens_hsa046721.11393320
63Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.10085633
64Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.09501305
65Ether lipid metabolism_Homo sapiens_hsa005651.09105833
66Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.08884406
67Antigen processing and presentation_Homo sapiens_hsa046121.04606691
68Fatty acid degradation_Homo sapiens_hsa000711.04449195
69Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.04436075
70Fat digestion and absorption_Homo sapiens_hsa049751.03699061
71Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.03074869
72Influenza A_Homo sapiens_hsa051641.01655225
73Circadian rhythm_Homo sapiens_hsa047101.00929130
74ABC transporters_Homo sapiens_hsa020100.99808384
75Long-term potentiation_Homo sapiens_hsa047200.98841703
76RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.98570344
77mTOR signaling pathway_Homo sapiens_hsa041500.94995917
78Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.92679431
79Chemokine signaling pathway_Homo sapiens_hsa040620.91576262
80Purine metabolism_Homo sapiens_hsa002300.90327116
81Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.89347962
82Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.85078608
83Biosynthesis of amino acids_Homo sapiens_hsa012300.85054403
84Mineral absorption_Homo sapiens_hsa049780.82822620
85Hematopoietic cell lineage_Homo sapiens_hsa046400.80314146
86Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.76434687
87Estrogen signaling pathway_Homo sapiens_hsa049150.75721522
88Apoptosis_Homo sapiens_hsa042100.75660034
89Prion diseases_Homo sapiens_hsa050200.75308011
90Herpes simplex infection_Homo sapiens_hsa051680.75013271
91Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.73632195
92Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.72776113
93Vibrio cholerae infection_Homo sapiens_hsa051100.71430811
94Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.71087690
95Amoebiasis_Homo sapiens_hsa051460.68893211
96Central carbon metabolism in cancer_Homo sapiens_hsa052300.67109122
97Prolactin signaling pathway_Homo sapiens_hsa049170.65773783
98Calcium signaling pathway_Homo sapiens_hsa040200.63919915
99Adipocytokine signaling pathway_Homo sapiens_hsa049200.63676731
100Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.63571740
101Sphingolipid signaling pathway_Homo sapiens_hsa040710.63325926
102Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.62700579
103Glutathione metabolism_Homo sapiens_hsa004800.61824356
104cGMP-PKG signaling pathway_Homo sapiens_hsa040220.61221405
105SNARE interactions in vesicular transport_Homo sapiens_hsa041300.60236150
106Ovarian steroidogenesis_Homo sapiens_hsa049130.59648474
107AMPK signaling pathway_Homo sapiens_hsa041520.58914585
108beta-Alanine metabolism_Homo sapiens_hsa004100.57964456
109Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.56897287
110VEGF signaling pathway_Homo sapiens_hsa043700.56384171
111Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.55600314
112Hedgehog signaling pathway_Homo sapiens_hsa043400.55292794
113Jak-STAT signaling pathway_Homo sapiens_hsa046300.54643578
114Viral myocarditis_Homo sapiens_hsa054160.53962601
115T cell receptor signaling pathway_Homo sapiens_hsa046600.53866916
116Insulin secretion_Homo sapiens_hsa049110.53499152
117Endocytosis_Homo sapiens_hsa041440.52422479
118Measles_Homo sapiens_hsa051620.52172531
119Chemical carcinogenesis_Homo sapiens_hsa052040.51397404
120N-Glycan biosynthesis_Homo sapiens_hsa005100.50378166
121Phosphatidylinositol signaling system_Homo sapiens_hsa040700.50362296
122African trypanosomiasis_Homo sapiens_hsa051430.50272457
123Regulation of autophagy_Homo sapiens_hsa041400.49404910
124Hepatitis C_Homo sapiens_hsa051600.46638460
125Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.46560061
126Bile secretion_Homo sapiens_hsa049760.45688236
127Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.45229962
128Circadian entrainment_Homo sapiens_hsa047130.44960798
129Hepatitis B_Homo sapiens_hsa051610.44491851
130Taste transduction_Homo sapiens_hsa047420.43813244
131Collecting duct acid secretion_Homo sapiens_hsa049660.43049567
132Acute myeloid leukemia_Homo sapiens_hsa052210.42979657
133Inositol phosphate metabolism_Homo sapiens_hsa005620.41641102
134Shigellosis_Homo sapiens_hsa051310.41371969
135Thyroid hormone synthesis_Homo sapiens_hsa049180.41363001
136RNA degradation_Homo sapiens_hsa030180.39645907
137Phospholipase D signaling pathway_Homo sapiens_hsa040720.39129740
138Arachidonic acid metabolism_Homo sapiens_hsa005900.38882473
139ErbB signaling pathway_Homo sapiens_hsa040120.38628107
140Tryptophan metabolism_Homo sapiens_hsa003800.38090407
141Neurotrophin signaling pathway_Homo sapiens_hsa047220.37919757
142Complement and coagulation cascades_Homo sapiens_hsa046100.37527541
143HIF-1 signaling pathway_Homo sapiens_hsa040660.37190159
144AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.36227911
145Legionellosis_Homo sapiens_hsa051340.34944122
146Renal cell carcinoma_Homo sapiens_hsa052110.34698369
147Choline metabolism in cancer_Homo sapiens_hsa052310.34064004
148Synaptic vesicle cycle_Homo sapiens_hsa047210.32967046
149Systemic lupus erythematosus_Homo sapiens_hsa053220.31209588
150MAPK signaling pathway_Homo sapiens_hsa040100.30258887
151Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.28562225
152Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.27816447
153Metabolic pathways_Homo sapiens_hsa011000.27750915
154Vascular smooth muscle contraction_Homo sapiens_hsa042700.27473622
155Cocaine addiction_Homo sapiens_hsa050300.26349360
156Longevity regulating pathway - mammal_Homo sapiens_hsa042110.26070884
157cAMP signaling pathway_Homo sapiens_hsa040240.25078241
158Pentose and glucuronate interconversions_Homo sapiens_hsa000400.24488964
159B cell receptor signaling pathway_Homo sapiens_hsa046620.23942276
160Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.23547242
161Salivary secretion_Homo sapiens_hsa049700.22363048
162Thyroid hormone signaling pathway_Homo sapiens_hsa049190.21837264
163Gastric acid secretion_Homo sapiens_hsa049710.21617521
164Glutamatergic synapse_Homo sapiens_hsa047240.21456862
165Renin-angiotensin system_Homo sapiens_hsa046140.21314350
166Pancreatic secretion_Homo sapiens_hsa049720.19225953
167Protein digestion and absorption_Homo sapiens_hsa049740.19179645
168Wnt signaling pathway_Homo sapiens_hsa043100.18678964
169Steroid hormone biosynthesis_Homo sapiens_hsa001400.17544489
170Alcoholism_Homo sapiens_hsa050340.17195505
171Viral carcinogenesis_Homo sapiens_hsa052030.15533321
172Type II diabetes mellitus_Homo sapiens_hsa049300.15265195
173Dopaminergic synapse_Homo sapiens_hsa047280.13655102

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