TDRD7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the Tudor family of proteins. This protein contains conserved Tudor domains and LOTUS domains. It is a component of RNA granules, which function in RNA processing. Mutations in this gene have been associated with cataract formation in mouse and human. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fusion of sperm to egg plasma membrane (GO:0007342)5.19507351
2cellular response to type I interferon (GO:0071357)4.98100703
3type I interferon signaling pathway (GO:0060337)4.98100703
4response to type I interferon (GO:0034340)4.92592085
5sperm motility (GO:0030317)4.89911410
6cilium or flagellum-dependent cell motility (GO:0001539)4.69652030
7response to peptidoglycan (GO:0032494)4.62365927
8neutrophil activation involved in immune response (GO:0002283)4.59727022
9macrophage activation involved in immune response (GO:0002281)4.55650062
10regulation of interferon-alpha production (GO:0032647)4.47152147
11regulation of interferon-beta biosynthetic process (GO:0045357)4.34983973
12lipopolysaccharide-mediated signaling pathway (GO:0031663)4.27880633
13positive regulation of interferon-alpha production (GO:0032727)4.21747906
14negative regulation of interleukin-12 production (GO:0032695)4.11185013
15regulation of T-helper 1 cell differentiation (GO:0045625)4.05950633
16plasma membrane fusion (GO:0045026)4.05562841
17acrosome assembly (GO:0001675)4.04400772
18lens development in camera-type eye (GO:0002088)3.99407986
19acrosome reaction (GO:0007340)3.99369554
20positive regulation by symbiont of host defense response (GO:0052509)3.98459456
21modulation by symbiont of host defense response (GO:0052031)3.98459456
22modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.98459456
23modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.98459456
24positive regulation by organism of defense response of other organism involved in symbiotic interact3.98459456
25modulation by symbiont of host immune response (GO:0052553)3.98459456
26multicellular organism reproduction (GO:0032504)3.93309744
27antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.91931006
28antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.88725413
29positive regulation of gamma-delta T cell activation (GO:0046645)3.82236966
30low-density lipoprotein particle clearance (GO:0034383)3.78684667
31detection of molecule of bacterial origin (GO:0032490)3.77761900
32cell wall macromolecule catabolic process (GO:0016998)3.71979027
33cell wall macromolecule metabolic process (GO:0044036)3.71979027
34regulation of vitamin D biosynthetic process (GO:0060556)3.70574957
35antigen processing and presentation of endogenous antigen (GO:0019883)3.69277043
36interferon-gamma-mediated signaling pathway (GO:0060333)3.68267690
37regulation of rhodopsin mediated signaling pathway (GO:0022400)3.66471693
38regulation of cytokine secretion involved in immune response (GO:0002739)3.66165188
39response to interferon-alpha (GO:0035455)3.59648676
40rhodopsin mediated signaling pathway (GO:0016056)3.56966167
41reproduction (GO:0000003)3.56763563
42immunoglobulin mediated immune response (GO:0016064)3.56500666
43positive regulation of type 2 immune response (GO:0002830)3.55648969
44positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.54888908
45sperm-egg recognition (GO:0035036)3.54528057
46T-helper 1 type immune response (GO:0042088)3.53226997
47macroautophagy (GO:0016236)3.51479602
48piRNA metabolic process (GO:0034587)3.49817370
49negative regulation of cell killing (GO:0031342)3.45744477
50negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.45744477
51cellular response to interferon-alpha (GO:0035457)3.42774310
52detection of other organism (GO:0098543)3.42561586
53negative regulation of viral genome replication (GO:0045071)3.38971477
54positive regulation of interferon-beta production (GO:0032728)3.30165416
55cell-cell recognition (GO:0009988)3.27416109
56regulation of vitamin metabolic process (GO:0030656)3.25826221
57plasma lipoprotein particle clearance (GO:0034381)3.25629383
58positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.25096362
59regulation of T-helper 2 cell differentiation (GO:0045628)3.23966050
60detection of external biotic stimulus (GO:0098581)3.22967839
61defense response to protozoan (GO:0042832)3.20336376
62antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.18871295
63axonemal dynein complex assembly (GO:0070286)3.18751415
64granulocyte activation (GO:0036230)3.17603191
65alpha-linolenic acid metabolic process (GO:0036109)3.15721668
66negative regulation of cytokine production involved in immune response (GO:0002719)3.14598650
67binding of sperm to zona pellucida (GO:0007339)3.14165089
68germinal center formation (GO:0002467)3.13832921
69spermatid development (GO:0007286)3.13576166
70detection of bacterium (GO:0016045)3.13130786
71positive regulation of chemokine biosynthetic process (GO:0045080)3.12676973
72epithelial cilium movement (GO:0003351)3.10085081
73regulation of type 2 immune response (GO:0002828)3.09200845
74visual perception (GO:0007601)3.08314534
75NIK/NF-kappaB signaling (GO:0038061)3.07811257
76triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.07168292
77response to muramyl dipeptide (GO:0032495)3.06533665
78regulation of chemokine biosynthetic process (GO:0045073)3.06015935
79lens fiber cell development (GO:0070307)3.05372503
80myeloid cell activation involved in immune response (GO:0002275)3.04830704
81sensory perception of light stimulus (GO:0050953)3.04224971
82regulation of dendritic cell antigen processing and presentation (GO:0002604)3.02402180
83response to protozoan (GO:0001562)3.02359009
84regulation of podosome assembly (GO:0071801)3.01454299
85myeloid dendritic cell differentiation (GO:0043011)3.00690480
86neutrophil activation (GO:0042119)3.00175234
87regulation of type I interferon-mediated signaling pathway (GO:0060338)3.00091114
88response to host immune response (GO:0052572)2.99903446
89response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.99903446
90negative regulation of inclusion body assembly (GO:0090084)2.99252643
91regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.97672200
92positive regulation of NF-kappaB import into nucleus (GO:0042346)2.97112231
93cellular glucuronidation (GO:0052695)2.95361695
94regulation of cholesterol storage (GO:0010885)2.94916880
95lipoprotein transport (GO:0042953)2.94845997
96motile cilium assembly (GO:0044458)2.94410637
97macrophage activation (GO:0042116)2.93947643
98T cell migration (GO:0072678)2.91957313
99positive regulation of cellular amide metabolic process (GO:0034250)2.90884992
100urea cycle (GO:0000050)2.89934338
101urea metabolic process (GO:0019627)2.89934338
102male meiosis (GO:0007140)2.89599223
103fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.89032678
104positive regulation of toll-like receptor signaling pathway (GO:0034123)2.88562832
105regulation of interleukin-8 biosynthetic process (GO:0045414)2.87854335
106reverse cholesterol transport (GO:0043691)2.85168825
107negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.84542037
108cellular response to interferon-gamma (GO:0071346)2.83432664
109regulation of RIG-I signaling pathway (GO:0039535)2.80676422
110organic cation transport (GO:0015695)2.78582192
111glucuronate metabolic process (GO:0019585)2.77752256
112uronic acid metabolic process (GO:0006063)2.77752256
113detection of biotic stimulus (GO:0009595)2.77733699
114response to host (GO:0075136)2.76313502
115response to host defenses (GO:0052200)2.76313502
116response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.76313502
117phagocytosis, engulfment (GO:0006911)2.75692843
118high-density lipoprotein particle remodeling (GO:0034375)2.75472861
119retinal rod cell development (GO:0046548)2.74279151
120phototransduction (GO:0007602)2.73944693
121phospholipid homeostasis (GO:0055091)2.73818744
122phototransduction, visible light (GO:0007603)2.73724574
123regulation of interleukin-12 production (GO:0032655)2.72293701
124modulation of growth of symbiont involved in interaction with host (GO:0044144)2.71373196
125regulation of growth of symbiont in host (GO:0044126)2.71373196
126negative regulation of growth of symbiont in host (GO:0044130)2.71373196
127negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.71373196
128carnitine transmembrane transport (GO:1902603)2.71304876
129regulation of interferon-beta production (GO:0032648)2.71181784
130carnitine transport (GO:0015879)2.71060364
131amino-acid betaine transport (GO:0015838)2.71060364
132response to interferon-gamma (GO:0034341)2.70245816
133cellular response to virus (GO:0098586)2.70055764
134regulation of chronic inflammatory response (GO:0002676)2.70040260
135detection of light stimulus involved in visual perception (GO:0050908)2.70005678
136detection of light stimulus involved in sensory perception (GO:0050962)2.70005678
137retinal cone cell development (GO:0046549)2.69977287
138synaptonemal complex organization (GO:0070193)2.69906663
139complement activation, alternative pathway (GO:0006957)2.69715744
140positive regulation of Cdc42 GTPase activity (GO:0043089)2.69246021
141cholesterol efflux (GO:0033344)2.69223615
142regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.68565057
143cilium movement (GO:0003341)2.67806922
144B cell mediated immunity (GO:0019724)2.67365341
145regulation of protein polyubiquitination (GO:1902914)2.67243840
146regulation of T cell tolerance induction (GO:0002664)2.66818809
147positive regulation of antigen processing and presentation (GO:0002579)2.66020143
148positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.65854948
149regulation of antigen processing and presentation (GO:0002577)2.65804771
150sperm capacitation (GO:0048240)2.65471752
151regulation of gamma-delta T cell activation (GO:0046643)2.64922194
152cellular response to lipopolysaccharide (GO:0071222)2.64663977
153cellular response to molecule of bacterial origin (GO:0071219)2.63899477
154myeloid dendritic cell activation (GO:0001773)2.63749356
155regulation of triglyceride catabolic process (GO:0010896)2.63140210
156production of molecular mediator involved in inflammatory response (GO:0002532)2.62859146
157regulation of T-helper cell differentiation (GO:0045622)2.62110953
158glycosphingolipid catabolic process (GO:0046479)2.61833945
159negative regulation of T cell mediated immunity (GO:0002710)2.61299857
160detection of light stimulus (GO:0009583)2.61215728
161photoreceptor cell development (GO:0042461)2.58769458
162nitrogen cycle metabolic process (GO:0071941)2.58117755
163synaptonemal complex assembly (GO:0007130)2.57195846
164epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.57061526
165detection of visible light (GO:0009584)2.56628667
166bile acid and bile salt transport (GO:0015721)2.55245588
167photoreceptor cell maintenance (GO:0045494)2.53880870
168phospholipid efflux (GO:0033700)2.52826002
169L-phenylalanine catabolic process (GO:0006559)2.52614560
170erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.52614560
171positive regulation of lipid catabolic process (GO:0050996)2.52413267
172hormone catabolic process (GO:0042447)2.50351617
173positive regulation of guanylate cyclase activity (GO:0031284)2.49105396
174protein-lipid complex remodeling (GO:0034368)2.46332040
175macromolecular complex remodeling (GO:0034367)2.46332040
176plasma lipoprotein particle remodeling (GO:0034369)2.46332040
177lipid translocation (GO:0034204)2.44676655
178phospholipid translocation (GO:0045332)2.44676655
179positive regulation of glycolytic process (GO:0045821)2.42630629
180peptidyl-glutamic acid carboxylation (GO:0017187)2.42544346
181protein carboxylation (GO:0018214)2.42544346
182positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.40748855
183eye photoreceptor cell development (GO:0042462)2.39198756
184single fertilization (GO:0007338)2.38125196
185erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.34871129
186L-phenylalanine metabolic process (GO:0006558)2.34871129
187CDP-diacylglycerol biosynthetic process (GO:0016024)2.31886516
188flavonoid metabolic process (GO:0009812)2.29656915
189sexual reproduction (GO:0019953)2.28851929
190growth hormone receptor signaling pathway (GO:0060396)2.27405720
191fatty acid transmembrane transport (GO:1902001)2.26468639
192fructose metabolic process (GO:0006000)2.24892716
193protein-lipid complex assembly (GO:0065005)2.23707897
194mannose metabolic process (GO:0006013)2.23705639
195regulation of protein activation cascade (GO:2000257)2.23705414
196cytolysis (GO:0019835)2.23000862
197fertilization (GO:0009566)2.22191023
198sulfur amino acid catabolic process (GO:0000098)2.21574953
199regulation of guanylate cyclase activity (GO:0031282)2.20600658
200regulation of cholesterol esterification (GO:0010872)2.20180330

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human3.63834758
2EGR1_19374776_ChIP-ChIP_THP-1_Human3.37480878
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.28646489
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.24606704
5NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.88837616
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.81000449
7SMAD_19615063_ChIP-ChIP_OVARY_Human2.79098482
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.70217420
9STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.67540825
10RXR_22158963_ChIP-Seq_LIVER_Mouse2.49428688
11LXR_22158963_ChIP-Seq_LIVER_Mouse2.47940890
12STAT4_19710469_ChIP-ChIP_TH1__Mouse2.39989832
13BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.30939388
14PPARA_22158963_ChIP-Seq_LIVER_Mouse2.22230417
15IRF8_22096565_ChIP-ChIP_GC-B_Human2.17633603
16BRD4_27068464_Chip-Seq_AML-cells_Mouse1.97518319
17CDX2_19796622_ChIP-Seq_MESCs_Mouse1.97353748
18VDR_24763502_ChIP-Seq_THP-1_Human1.96614851
19SPI1_23127762_ChIP-Seq_K562_Human1.89192436
20SPI1_23547873_ChIP-Seq_NB4_Human1.83130746
21Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.80145633
22RUNX_20019798_ChIP-Seq_JUKART_Human1.78712303
23VDR_21846776_ChIP-Seq_THP-1_Human1.74276790
24* FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.71597699
25IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.65337116
26SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.64615657
27MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.62550514
28PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.62460589
29TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.61914256
30MYB_26560356_Chip-Seq_TH2_Human1.60122264
31FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.57141921
32SCL_19346495_ChIP-Seq_HPC-7_Human1.49716064
33IRF8_27001747_Chip-Seq_BMDM_Mouse1.47014767
34IRF8_21731497_ChIP-ChIP_J774_Mouse1.46075374
35RUNX1_22412390_ChIP-Seq_EML_Mouse1.44508279
36PU_27001747_Chip-Seq_BMDM_Mouse1.44245828
37RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.43664930
38MAF_26560356_Chip-Seq_TH1_Human1.43299993
39EGR1_23403033_ChIP-Seq_LIVER_Mouse1.42395364
40ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.41516868
41STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.40109006
42GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40074076
43BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.37048850
44MYB_26560356_Chip-Seq_TH1_Human1.36852883
45FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.33451926
46* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.33167718
47E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.33006451
48NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.32682177
49EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.31026596
50TRIM28_21343339_ChIP-Seq_HEK293_Human1.29891200
51* FOXA2_19822575_ChIP-Seq_HepG2_Human1.28174434
52TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26200347
53KDM2B_26808549_Chip-Seq_SUP-B15_Human1.25418880
54* TCF7_22412390_ChIP-Seq_EML_Mouse1.23473073
55GATA2_21666600_ChIP-Seq_HMVEC_Human1.22231337
56TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.22074774
57PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20086549
58GATA1_19941827_ChIP-Seq_MEL_Mouse1.19569356
59VDR_24787735_ChIP-Seq_THP-1_Human1.16824919
60EP300_21415370_ChIP-Seq_HL-1_Mouse1.12400949
61SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11168192
62EGR1_19032775_ChIP-ChIP_M12_Human1.09403830
63NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.08703043
64ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.08345042
65* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07311047
66GATA2_22383799_ChIP-Seq_G1ME_Mouse1.06216467
67LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.04414662
68* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04224453
69ZNF217_24962896_ChIP-Seq_MCF-7_Human1.03843245
70* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03007049
71MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.02916121
72STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.02865059
73* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02614436
74CLOCK_20551151_ChIP-Seq_293T_Human1.01909685
75ELK3_25401928_ChIP-Seq_HUVEC_Human1.01332733
76* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00931919
77PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.00717240
78GATA3_27048872_Chip-Seq_THYMUS_Human1.00584199
79UTX_26944678_Chip-Seq_JUKART_Human1.00576539
80SOX2_20726797_ChIP-Seq_SW620_Human0.99855150
81PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.99547715
82* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99310427
83SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.98866345
84SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.98298461
85DROSHA_22980978_ChIP-Seq_HELA_Human0.98018928
86KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.97577781
87KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.97160959
88ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.96323569
89PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95979316
90SALL4_18804426_ChIP-ChIP_XEN_Mouse0.95149795
91CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.94237090
92KDM2B_26808549_Chip-Seq_DND41_Human0.93949618
93CJUN_26792858_Chip-Seq_BT549_Human0.93653947
94ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.92783249
95SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92537444
96SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.92452737
97STAT6_21828071_ChIP-Seq_BEAS2B_Human0.92223051
98KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.91997917
99FOXO3_23340844_ChIP-Seq_DLD1_Human0.91799573
100ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.91300945
101TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90913026
102NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.90605356
103NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.90574122
104AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.89002278
105GATA3_26560356_Chip-Seq_TH2_Human0.87514020
106SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.87178035
107SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.87178035
108GATA1_22383799_ChIP-Seq_G1ME_Mouse0.86695867
109TFEB_21752829_ChIP-Seq_HELA_Human0.86690411
110FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.86286750
111PPAR_26484153_Chip-Seq_NCI-H1993_Human0.86163721
112NRF2_20460467_ChIP-Seq_MEFs_Mouse0.85859798
113NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.85859798
114* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85814926
115SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.85438654
116BCAT_22108803_ChIP-Seq_LS180_Human0.84965765
117TBX20_22328084_ChIP-Seq_HEART_Mouse0.84535896
118TBX20_22080862_ChIP-Seq_HEART_Mouse0.84535896
119CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.84230990
120MTF2_20144788_ChIP-Seq_MESCs_Mouse0.82746768
121ELK4_26923725_Chip-Seq_MESODERM_Mouse0.82381032
122KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.81897279
123TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.81409994
124TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.81376790
125CBP_20019798_ChIP-Seq_JUKART_Human0.80974246
126IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.80974246
127GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80284451
128MAF_26560356_Chip-Seq_TH2_Human0.79507614
129TP63_17297297_ChIP-ChIP_HaCaT_Human0.79437776
130SOX2_27498859_Chip-Seq_STOMACH_Mouse0.79388154
131THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.79074390
132ESR2_21235772_ChIP-Seq_MCF-7_Human0.78537798
133EZH2_22144423_ChIP-Seq_EOC_Human0.77871657
134GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77393465
135TP63_23658742_ChIP-Seq_EP156T_Human0.77372460
136KDM2B_26808549_Chip-Seq_REH_Human0.77139839
137MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.76885335
138GATA1_19941826_ChIP-Seq_K562_Human0.76566210
139STAT1_17558387_ChIP-Seq_HELA_Human0.76304012
140AHR_22903824_ChIP-Seq_MCF-7_Human0.75362282
141GATA2_19941826_ChIP-Seq_K562_Human0.74645305
142SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.73770719
143GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.73637981
144GATA1_19941827_ChIP-Seq_MEL86_Mouse0.73231582
145VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.73033298
146PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.72574493
147RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.71725987
148TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.71207469
149MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.70593181
150SOX9_24532713_ChIP-Seq_HFSC_Mouse0.70316376
151WT1_25993318_ChIP-Seq_PODOCYTE_Human0.69635353
152JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.69481750
153ARNT_22903824_ChIP-Seq_MCF-7_Human0.69229916
154KDM2B_26808549_Chip-Seq_K562_Human0.67307062
155SUZ12_27294783_Chip-Seq_ESCs_Mouse0.67001674
156MYB_21317192_ChIP-Seq_ERMYB_Mouse0.66723429
157NFE2_27457419_Chip-Seq_LIVER_Mouse0.66589365
158* HNF4A_19822575_ChIP-Seq_HepG2_Human0.66470363
159* SMAD4_21799915_ChIP-Seq_A2780_Human0.65904575
160RARG_19884340_ChIP-ChIP_MEFs_Mouse0.65870476
161GATA1_22025678_ChIP-Seq_K562_Human0.65809801
162SMAD4_21741376_ChIP-Seq_EPCs_Human0.65735706
163RUNX1_27514584_Chip-Seq_MCF-7_Human0.64918141
164AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.64887318

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization5.22817565
2MP0003011_delayed_dark_adaptation4.94581863
3MP0005360_urolithiasis3.78245864
4MP0005551_abnormal_eye_electrophysiolog3.67314625
5MP0002139_abnormal_hepatobiliary_system3.49276585
6MP0005253_abnormal_eye_physiology3.21046727
7MP0002254_reproductive_system_inflammat2.92971495
8MP0002148_abnormal_hypersensitivity_rea2.71117349
9MP0002090_abnormal_vision2.60822785
10MP0005365_abnormal_bile_salt2.60600795
11MP0005025_abnormal_response_to2.55217391
12MP0005000_abnormal_immune_tolerance2.50910963
13MP0005387_immune_system_phenotype2.50357620
14MP0001790_abnormal_immune_system2.50357620
15MP0003252_abnormal_bile_duct2.39658396
16MP0005085_abnormal_gallbladder_physiolo2.38846440
17MP0005451_abnormal_body_composition2.38528149
18MP0005671_abnormal_response_to2.37413612
19MP0009840_abnormal_foam_cell2.36710361
20MP0002697_abnormal_eye_size2.32851961
21MP0010329_abnormal_lipoprotein_level2.25080513
22MP0003191_abnormal_cellular_cholesterol2.18538463
23MP0008875_abnormal_xenobiotic_pharmacok2.17988321
24MP0001800_abnormal_humoral_immune2.17636147
25MP0002452_abnormal_antigen_presenting2.09710110
26MP0002723_abnormal_immune_serum2.07103698
27MP0008004_abnormal_stomach_pH2.07056805
28MP0000685_abnormal_immune_system1.97659771
29MP0010155_abnormal_intestine_physiology1.96742253
30MP0003705_abnormal_hypodermis_morpholog1.91567942
31MP0001324_abnormal_eye_pigmentation1.85607512
32MP0008260_abnormal_autophagy1.80089124
33MP0001819_abnormal_immune_cell1.78777185
34MP0002420_abnormal_adaptive_immunity1.77169956
35MP0003950_abnormal_plasma_membrane1.71793321
36MP0001845_abnormal_inflammatory_respons1.70778023
37MP0005193_abnormal_anterior_eye1.67368455
38MP0000604_amyloidosis1.61125716
39MP0006054_spinal_hemorrhage1.59942440
40MP0004233_abnormal_muscle_weight1.59770267
41MP0005391_vision/eye_phenotype1.57031464
42MP0005195_abnormal_posterior_eye1.57001189
43MP0004019_abnormal_vitamin_homeostasis1.51605671
44MP0003453_abnormal_keratinocyte_physiol1.51113736
45MP0003300_gastrointestinal_ulcer1.50863386
46MP0005167_abnormal_blood-brain_barrier1.46435795
47MP0005310_abnormal_salivary_gland1.44912199
48MP0002405_respiratory_system_inflammati1.44773847
49MP0003690_abnormal_glial_cell1.44725420
50MP0003303_peritoneal_inflammation1.42853981
51MP0001853_heart_inflammation1.42825878
52MP0005058_abnormal_lysosome_morphology1.41721049
53MP0002998_abnormal_bone_remodeling1.41061993
54MP0001666_abnormal_nutrient_absorption1.40892194
55MP0003698_abnormal_male_reproductive1.40715248
56MP0000465_gastrointestinal_hemorrhage1.40304392
57MP0005670_abnormal_white_adipose1.39487240
58MP0006072_abnormal_retinal_apoptosis1.39069793
59MP0002118_abnormal_lipid_homeostasis1.38742942
60MP0009333_abnormal_splenocyte_physiolog1.38360880
61MP0003075_altered_response_to1.35876899
62MP0004130_abnormal_muscle_cell1.32749681
63MP0003448_altered_tumor_morphology1.32367425
64MP0003436_decreased_susceptibility_to1.31408505
65MP0000569_abnormal_digit_pigmentation1.31183145
66MP0000343_altered_response_to1.30763591
67MP0000716_abnormal_immune_system1.28808189
68MP0010352_gastrointestinal_tract_polyps1.28399844
69MP0000609_abnormal_liver_physiology1.26931372
70MP0005197_abnormal_uvea_morphology1.25855086
71MP0001764_abnormal_homeostasis1.24407617
72MP0003763_abnormal_thymus_physiology1.24098770
73MP0000858_altered_metastatic_potential1.21547120
74MP0010234_abnormal_vibrissa_follicle1.20670801
75MP0002332_abnormal_exercise_endurance1.19337633
76MP0005397_hematopoietic_system_phenotyp1.19257932
77MP0001545_abnormal_hematopoietic_system1.19257932
78MP0002166_altered_tumor_susceptibility1.18502582
79MP0002398_abnormal_bone_marrow1.16497756
80MP0003656_abnormal_erythrocyte_physiolo1.16180403
81MP0003724_increased_susceptibility_to1.15649217
82MP0002168_other_aberrant_phenotype1.13704711
83MP0004510_myositis1.12656119
84MP0005319_abnormal_enzyme/_coenzyme1.11986280
85MP0000015_abnormal_ear_pigmentation1.09748268
86MP0005666_abnormal_adipose_tissue1.09681152
87MP0005083_abnormal_biliary_tract1.09472641
88MP0003329_amyloid_beta_deposits1.08804759
89MP0003172_abnormal_lysosome_physiology1.08779005
90MP0002138_abnormal_hepatobiliary_system1.08230176
91MP0001929_abnormal_gametogenesis1.08156576
92MP0002229_neurodegeneration1.07170397
93MP0010368_abnormal_lymphatic_system1.06901667
94MP0002877_abnormal_melanocyte_morpholog1.05625682
95MP0005408_hypopigmentation1.05531957
96MP0006082_CNS_inflammation1.05252262
97MP0003806_abnormal_nucleotide_metabolis1.02695684
98MP0001958_emphysema1.01408531
99MP0004381_abnormal_hair_follicle1.00949322
100MP0001873_stomach_inflammation1.00345426
101MP0002006_tumorigenesis1.00090182
102MP0002971_abnormal_brown_adipose0.99959747
103MP0003045_fibrosis0.99901886
104MP0002429_abnormal_blood_cell0.96954109
105MP0003828_pulmonary_edema0.96824027
106MP0005584_abnormal_enzyme/coenzyme_acti0.95900381
107MP0005332_abnormal_amino_acid0.95829391
108MP0009764_decreased_sensitivity_to0.95050609
109MP0004883_abnormal_blood_vessel0.94770633
110MP0001851_eye_inflammation0.93896475
111MP0000689_abnormal_spleen_morphology0.92853733
112MP0003195_calcinosis0.91561040
113MP0002722_abnormal_immune_system0.91481816
114MP0002132_abnormal_respiratory_system0.88731158
115MP0008438_abnormal_cutaneous_collagen0.88262724
116MP0000371_diluted_coat_color0.87191785
117MP0005464_abnormal_platelet_physiology0.86799976
118MP0009763_increased_sensitivity_to0.86222218
119MP0008469_abnormal_protein_level0.85810520
120MP0001533_abnormal_skeleton_physiology0.84791855
121MP0001835_abnormal_antigen_presentation0.83721127
122MP0005076_abnormal_cell_differentiation0.83232642
123MP0009278_abnormal_bone_marrow0.82677438
124MP0009115_abnormal_fat_cell0.82478833
125MP0002419_abnormal_innate_immunity0.82426911
126MP0005535_abnormal_body_temperature0.82021429
127MP0004858_abnormal_nervous_system0.81706804
128MP0005023_abnormal_wound_healing0.79651087
129MP0003091_abnormal_cell_migration0.77936500
130MP0005390_skeleton_phenotype0.77745769
131MP0002295_abnormal_pulmonary_circulatio0.77612056
132MP0004185_abnormal_adipocyte_glucose0.77091293
133MP0009785_altered_susceptibility_to0.76876408
134MP0004808_abnormal_hematopoietic_stem0.76517347
135MP0005623_abnormal_meninges_morphology0.75856240
136MP0004947_skin_inflammation0.74670996
137MP0009780_abnormal_chondrocyte_physiolo0.74642721
138MP0001346_abnormal_lacrimal_gland0.74636009
139MP0004264_abnormal_extraembryonic_tissu0.74620112
140MP0005166_decreased_susceptibility_to0.71339138
141MP0010307_abnormal_tumor_latency0.70843370
142MP0003866_abnormal_defecation0.69106592
143MP0004272_abnormal_basement_membrane0.69026698
144MP0001663_abnormal_digestive_system0.68748872
145MP0005334_abnormal_fat_pad0.68668532
146MP0001879_abnormal_lymphatic_vessel0.67322584
147MP0000920_abnormal_myelination0.67168166
148MP0003634_abnormal_glial_cell0.66884820
149MP0002161_abnormal_fertility/fecundity0.66822972
150MP0005375_adipose_tissue_phenotype0.66137893
151MP0009643_abnormal_urine_homeostasis0.66055534
152MP0003795_abnormal_bone_structure0.64577104
153MP0003183_abnormal_peptide_metabolism0.64271740
154MP0002928_abnormal_bile_duct0.63866159
155MP0001765_abnormal_ion_homeostasis0.63649885
156MP0003633_abnormal_nervous_system0.63090040
157MP0005164_abnormal_response_to0.62492468
158MP0000249_abnormal_blood_vessel0.62046326
159MP0000013_abnormal_adipose_tissue0.61250779
160MP0002638_abnormal_pupillary_reflex0.60443797
161MP0005647_abnormal_sex_gland0.58657121
162MP0002092_abnormal_eye_morphology0.57539883

Predicted human phenotypes

RankGene SetZ-score
1Nuclear cataract (HP:0100018)9.72394543
2Zonular cataract (HP:0010920)9.04074028
3Congenital stationary night blindness (HP:0007642)5.23508318
4Pigmentary retinal degeneration (HP:0001146)4.98574492
5Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.96432868
6Absent/shortened dynein arms (HP:0200106)4.92807371
7Dynein arm defect of respiratory motile cilia (HP:0012255)4.92807371
8Recurrent bacterial skin infections (HP:0005406)4.72310760
9Eczematoid dermatitis (HP:0000976)4.68684103
10Recurrent abscess formation (HP:0002722)4.60179172
11Optic neuritis (HP:0100653)4.58962356
12Retrobulbar optic neuritis (HP:0100654)4.58962356
13Orchitis (HP:0100796)4.57179929
14Abnormality of macrophages (HP:0004311)4.55936285
15Bony spicule pigmentary retinopathy (HP:0007737)4.44930751
16Abnormality of liposaccharide metabolism (HP:0010968)4.24556246
17Abnormality of glycosphingolipid metabolism (HP:0004343)4.24556246
18Abnormality of glycolipid metabolism (HP:0010969)4.24556246
19Myositis (HP:0100614)4.17431714
20Central scotoma (HP:0000603)4.05576447
21Chorioretinal atrophy (HP:0000533)3.99270492
22Nasal polyposis (HP:0100582)3.49562257
23Abnormal rod and cone electroretinograms (HP:0008323)3.47776641
24Dyschromatopsia (HP:0007641)3.46203195
25Absent rod-and cone-mediated responses on ERG (HP:0007688)3.45856090
26Scotoma (HP:0000575)3.44332768
27Abnormal respiratory motile cilium physiology (HP:0012261)3.41319877
28Stomatitis (HP:0010280)3.40891237
29Abolished electroretinogram (ERG) (HP:0000550)3.33883398
30Abnormality of macular pigmentation (HP:0008002)3.23560835
31Keratoconjunctivitis sicca (HP:0001097)3.21425567
32Abnormality of the nasal mucosa (HP:0000433)3.20684198
33Mediastinal lymphadenopathy (HP:0100721)3.18989335
34Dysostosis multiplex (HP:0000943)3.18142079
35Vacuolated lymphocytes (HP:0001922)3.13686011
36Cone-rod dystrophy (HP:0000548)3.02866816
37Congenital cataract (HP:0000519)3.02599701
38Retinal atrophy (HP:0001105)2.99709303
39Polar cataract (HP:0010696)2.98937665
40Gingivitis (HP:0000230)2.92786541
41Vasculitis (HP:0002633)2.92511312
42Abnormal respiratory epithelium morphology (HP:0012253)2.90261904
43Abnormal respiratory motile cilium morphology (HP:0005938)2.90261904
44Rhinitis (HP:0012384)2.90181490
45Recurrent skin infections (HP:0001581)2.87017274
46Chronic bronchitis (HP:0004469)2.86351576
47Deep venous thrombosis (HP:0002625)2.82498079
48Posterior subcapsular cataract (HP:0007787)2.82497486
49Keratoconjunctivitis (HP:0001096)2.81319160
50Macular degeneration (HP:0000608)2.78667465
51Xanthomatosis (HP:0000991)2.77716003
52Disinhibition (HP:0000734)2.75462808
53Attenuation of retinal blood vessels (HP:0007843)2.72298152
54Complement deficiency (HP:0004431)2.72008733
55Decreased central vision (HP:0007663)2.70712370
56Gastrointestinal infarctions (HP:0005244)2.69675965
57Subcapsular cataract (HP:0000523)2.67807139
58Choroideremia (HP:0001139)2.67344768
59Infertility (HP:0000789)2.66556421
60Pulmonary infiltrates (HP:0002113)2.62135200
61Recurrent viral infections (HP:0004429)2.59319528
62Abnormal ciliary motility (HP:0012262)2.56858143
63Anterior segment dysgenesis (HP:0007700)2.51627952
64Gingival bleeding (HP:0000225)2.45587527
65Recurrent fungal infections (HP:0002841)2.44050481
66Arterial thrombosis (HP:0004420)2.43812178
67Malnutrition (HP:0004395)2.43368582
68Elevated erythrocyte sedimentation rate (HP:0003565)2.42294643
69Urinary glycosaminoglycan excretion (HP:0003541)2.42094778
70Mucopolysacchariduria (HP:0008155)2.42094778
71Corneal dystrophy (HP:0001131)2.41367318
72Hemoptysis (HP:0002105)2.40308965
73Type II diabetes mellitus (HP:0005978)2.40114217
74Abnormality of the lower motor neuron (HP:0002366)2.38355948
75Intrahepatic cholestasis (HP:0001406)2.37982153
76Pendular nystagmus (HP:0012043)2.37580412
77Gangrene (HP:0100758)2.37493160
78Autoimmune hemolytic anemia (HP:0001890)2.36916217
79Meningitis (HP:0001287)2.35762598
80Decreased electroretinogram (ERG) amplitude (HP:0000654)2.34872475
81Photophobia (HP:0000613)2.34297487
82Abnormality of mucopolysaccharide metabolism (HP:0011020)2.33919729
83Abnormality of polysaccharide metabolism (HP:0011012)2.33919729
84Abnormality of glycosaminoglycan metabolism (HP:0004371)2.33919729
85Urticaria (HP:0001025)2.32768907
86Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.30860065
87Amblyopia (HP:0000646)2.29582063
88T lymphocytopenia (HP:0005403)2.29426378
89Clumsiness (HP:0002312)2.28904833
90Obstructive lung disease (HP:0006536)2.27019885
91Chronic obstructive pulmonary disease (HP:0006510)2.27019885
92Hypercholesterolemia (HP:0003124)2.26344910
93Glomerulonephritis (HP:0000099)2.25342749
94Abnormality of T cell number (HP:0011839)2.22798342
95Neurofibrillary tangles (HP:0002185)2.22454698
96Progressive visual loss (HP:0000529)2.22434779
97Abnormality of glutamine family amino acid metabolism (HP:0010902)2.20657403
98Basal ganglia calcification (HP:0002135)2.19709928
99Increased IgM level (HP:0003496)2.18454915
100Systemic lupus erythematosus (HP:0002725)2.17696020
101Epidermoid cyst (HP:0200040)2.17162831
102Increased IgE level (HP:0003212)2.16869818
103Hypoalphalipoproteinemia (HP:0003233)2.14325666
104Peritonitis (HP:0002586)2.13895849
105Myocardial infarction (HP:0001658)2.13535702
106Recurrent gram-negative bacterial infections (HP:0005420)2.10955520
107Hypobetalipoproteinemia (HP:0003563)2.10892173
108Asymmetric septal hypertrophy (HP:0001670)2.10065840
109Pulmonary embolism (HP:0002204)2.07913062
110Constricted visual fields (HP:0001133)2.07383867
111Polyneuropathy (HP:0001271)2.07209480
112Recurrent bronchitis (HP:0002837)2.06749288
113Encephalitis (HP:0002383)2.06678774
114Hypolipoproteinemia (HP:0010981)2.05526059
115Purpura (HP:0000979)2.05328858
116Hemorrhage of the eye (HP:0011885)2.04810099
117Hypergammaglobulinemia (HP:0010702)2.04041118
118Abnormality of complement system (HP:0005339)2.03372259
119Colitis (HP:0002583)1.99422236
120Progressive neurologic deterioration (HP:0002344)1.98940100
121Spontaneous hematomas (HP:0007420)1.98791166
122Autoimmune thrombocytopenia (HP:0001973)1.97777980
123Osteomyelitis (HP:0002754)1.96858281
124Episodic fever (HP:0001954)1.96690493
125Cerebral inclusion bodies (HP:0100314)1.96341750
126Joint swelling (HP:0001386)1.96211435
127Increased serum ferritin (HP:0003281)1.94899034
128Abnormality of the vasculature of the conjunctiva (HP:0008054)1.94710983
129Spastic tetraparesis (HP:0001285)1.94332397
130Cholecystitis (HP:0001082)1.93778077
131Abnormal gallbladder physiology (HP:0012438)1.93778077
132Increased neuronal autofluorescent lipopigment (HP:0002074)1.93667431
133Cellulitis (HP:0100658)1.93107437
134Anorexia (HP:0002039)1.92224313
135Inflammation of the large intestine (HP:0002037)1.91281892
136Glomerulopathy (HP:0100820)1.91005039
137Increased cerebral lipofuscin (HP:0011813)1.90837815
138Gastrointestinal stroma tumor (HP:0100723)1.90092999
139Interstitial pulmonary disease (HP:0006530)1.89978104
140Recurrent cutaneous fungal infections (HP:0011370)1.89908875
141Chronic mucocutaneous candidiasis (HP:0002728)1.89908875
142Retinitis pigmentosa (HP:0000510)1.89844094
143Loss of speech (HP:0002371)1.87886160
144Upper motor neuron abnormality (HP:0002127)1.87866252
145Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.87741601
146Abnormality of the common coagulation pathway (HP:0010990)1.86945275
147Gastrointestinal inflammation (HP:0004386)1.86287117
148Hydroxyprolinuria (HP:0003080)1.86235813
149Abnormality of proline metabolism (HP:0010907)1.86235813
150Mutism (HP:0002300)1.86080075
151Abnormality of aromatic amino acid family metabolism (HP:0004338)1.86057236
152Axonal loss (HP:0003447)1.85894080
153Supranuclear gaze palsy (HP:0000605)1.85701407
154Bone pain (HP:0002653)1.85471406
155Acne (HP:0001061)1.84479954
156Abnormality of monocarboxylic acid metabolism (HP:0010996)1.83636328
157Keratoconus (HP:0000563)1.82982338
158Increased corneal curvature (HP:0100692)1.82982338
159Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.81177241
160Nephritis (HP:0000123)1.80150075
161Petechiae (HP:0000967)1.79348397
162Apathy (HP:0000741)1.79062819
163Esophageal varix (HP:0002040)1.77785097
164Bronchitis (HP:0012387)1.77628453
165Neuronal loss in central nervous system (HP:0002529)1.76716221
166Spondylolisthesis (HP:0003302)1.76623458
167Hyperlipoproteinemia (HP:0010980)1.76167539
168Vascular calcification (HP:0004934)1.75938153
169Tetraparesis (HP:0002273)1.74767844
170Prolonged partial thromboplastin time (HP:0003645)1.74716524
171Polycythemia (HP:0001901)1.73728580
172Arthralgia (HP:0002829)1.73325512
173Lower limb hyperreflexia (HP:0002395)1.73102467
174Chronic otitis media (HP:0000389)1.72618671
175Abnormality of the endocardium (HP:0004306)1.72256039
176Fat malabsorption (HP:0002630)1.71622628
177Cardiovascular calcification (HP:0011915)1.69085434
178Vitreoretinal degeneration (HP:0000655)1.67795712
179Hand muscle atrophy (HP:0009130)1.67666186
180Amyloidosis (HP:0011034)1.66846712
181Skin nodule (HP:0200036)1.66768008
182Recurrent sinusitis (HP:0011108)1.65526175
183Hematochezia (HP:0002573)1.64405915
184Distal upper limb amyotrophy (HP:0007149)1.64394282
185Upper limb amyotrophy (HP:0009129)1.64394282

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK34.33580809
2PDK44.33580809
3IRAK33.31511689
4PDK23.18591191
5TESK12.86041808
6PRKD32.71718246
7IRAK42.42673254
8PRPF4B2.32794663
9ICK2.19548353
10WNK42.16009454
11STK392.14820363
12TRIB32.09229722
13ERN12.07397849
14PTK2B2.02936820
15BMPR22.02034610
16NLK1.98527316
17GRK71.91537084
18MAP3K31.90395964
19EPHB11.85881126
20RIPK11.79494968
21TBK11.79014357
22MAP4K11.78419252
23MATK1.78371933
24TAOK11.76238306
25MAP2K31.75114704
26GRK11.74540485
27RIPK41.74234750
28TYK21.66630270
29PTK61.65895441
30TAOK21.65267546
31CAMK1G1.61984327
32JAK11.60080295
33SIK11.48297645
34MST1R1.47816566
35MAP3K111.35796949
36ZAP701.35769407
37IKBKB1.35664654
38FGFR41.35180489
39CAMK1D1.30641408
40MOS1.30617862
41CAMKK11.29114485
42MAPK71.27223847
43FRK1.27200394
44WNK11.26577267
45NME21.25476113
46CDC42BPA1.24826879
47MAP3K141.16810517
48ACVR1B1.15178939
49STK101.12991291
50PBK1.12870617
51TAOK31.12004918
52PDK11.09560713
53PDPK11.02168515
54MAP3K11.00512763
55IKBKE1.00324235
56NEK90.99840670
57SYK0.97349923
58HCK0.97187321
59PKN20.95351818
60BTK0.93077288
61MAP3K130.92124029
62NTRK10.91007714
63MARK30.90924718
64LMTK20.89728331
65PAK60.88032252
66KSR20.87969995
67SGK20.87875784
68SIK30.87697906
69MAP3K50.86079461
70LYN0.85485279
71STK380.82716978
72CDK40.81444280
73TXK0.80848769
74BMX0.79620727
75PDGFRA0.79356428
76INSRR0.78847615
77DYRK1B0.77514434
78IRAK20.77255972
79PRKCH0.75763938
80MAP3K20.74000212
81CDK30.71284659
82MET0.69937422
83JAK20.69730167
84RET0.68768872
85YES10.68484872
86MAPK150.67803129
87SGK10.67290080
88CSK0.66316858
89FGFR30.64699276
90DAPK20.64422959
91TTN0.63564374
92JAK30.63083977
93BMPR1B0.62621812
94LCK0.61886947
95PTK20.61464760
96KIT0.60889985
97PINK10.58806351
98MAP2K20.58779067
99FER0.58617571
100PDGFRB0.57968666
101EGFR0.56381882
102PRKCZ0.56274959
103MAP3K100.56264929
104LRRK20.56097412
105PRKAA20.55611680
106TYRO30.55139545
107MAP3K90.54778573
108TIE10.53124274
109CLK10.52346211
110ARAF0.51665212
111MAP3K120.50587411
112TGFBR20.48991945
113TRPM70.48784880
114PAK20.48602120
115MELK0.47717470
116MAP2K60.47668420
117IRAK10.46824333
118PRKACG0.46341574
119CDK120.45901852
120CHUK0.45858008
121IGF1R0.45594225
122TEC0.45407183
123CDK60.43613103
124PRKAA10.43458409
125STK30.43296917
126DDR20.42963482
127MST40.42888455
128PIM10.42574383
129STK240.42540564
130MAP2K10.42440568
131PRKCQ0.42318821
132MAP3K80.41199903
133SGK30.41186840
134ERBB20.40771400
135SGK4940.39579126
136SGK2230.39579126
137BLK0.39455818
138PKN10.39293668
139GSK3A0.39281977
140NEK60.38767074
141CSF1R0.38600102
142KDR0.37786673
143FES0.37291176
144ERBB40.37082593
145TNK20.36917072
146GRK60.36427244
147EIF2AK30.36009132
148MAPK110.35424309
149MARK20.35397378
150FGR0.34269121
151PAK30.33931452
152HIPK20.33866348
153MAP2K40.33108734
154PIM20.32485929
155KSR10.32428858

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047444.54847535
2Nitrogen metabolism_Homo sapiens_hsa009102.76240258
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.49695647
4RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.36039348
5NF-kappa B signaling pathway_Homo sapiens_hsa040642.27898456
6Allograft rejection_Homo sapiens_hsa053302.26427055
7Other glycan degradation_Homo sapiens_hsa005112.26028114
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.21993960
9NOD-like receptor signaling pathway_Homo sapiens_hsa046212.08385815
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.01209385
11Primary bile acid biosynthesis_Homo sapiens_hsa001201.98184937
12Measles_Homo sapiens_hsa051621.91904781
13Graft-versus-host disease_Homo sapiens_hsa053321.90687376
14PPAR signaling pathway_Homo sapiens_hsa033201.83855626
15Autoimmune thyroid disease_Homo sapiens_hsa053201.81453334
16Arginine biosynthesis_Homo sapiens_hsa002201.75659967
17Pentose and glucuronate interconversions_Homo sapiens_hsa000401.72857430
18Asthma_Homo sapiens_hsa053101.72331768
19Rheumatoid arthritis_Homo sapiens_hsa053231.71303483
20Caffeine metabolism_Homo sapiens_hsa002321.70393374
21Staphylococcus aureus infection_Homo sapiens_hsa051501.64107392
22Intestinal immune network for IgA production_Homo sapiens_hsa046721.63252453
23Herpes simplex infection_Homo sapiens_hsa051681.59881996
24Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.57735129
25Complement and coagulation cascades_Homo sapiens_hsa046101.56723510
26Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.56395515
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.51321314
28Fat digestion and absorption_Homo sapiens_hsa049751.49730275
29Fatty acid degradation_Homo sapiens_hsa000711.48458815
30Type I diabetes mellitus_Homo sapiens_hsa049401.46308255
31Propanoate metabolism_Homo sapiens_hsa006401.39420028
32Bile secretion_Homo sapiens_hsa049761.39154681
33Hepatitis B_Homo sapiens_hsa051611.37704704
34Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.37255268
35ABC transporters_Homo sapiens_hsa020101.35792254
36Antigen processing and presentation_Homo sapiens_hsa046121.31976131
37Retinol metabolism_Homo sapiens_hsa008301.31448445
38Jak-STAT signaling pathway_Homo sapiens_hsa046301.30902093
39Chemokine signaling pathway_Homo sapiens_hsa040621.30034713
40Fatty acid biosynthesis_Homo sapiens_hsa000611.24285725
41Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.23890930
42Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.23871460
43Fatty acid metabolism_Homo sapiens_hsa012121.23844423
44Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.23631650
45Hematopoietic cell lineage_Homo sapiens_hsa046401.22638605
46Glycerolipid metabolism_Homo sapiens_hsa005611.20941126
47Pyruvate metabolism_Homo sapiens_hsa006201.20419496
48AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.20175162
49Starch and sucrose metabolism_Homo sapiens_hsa005001.20174645
50Dorso-ventral axis formation_Homo sapiens_hsa043201.16690613
51Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.14826125
52Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.14343544
53Carbohydrate digestion and absorption_Homo sapiens_hsa049731.13311383
54Chemical carcinogenesis_Homo sapiens_hsa052041.10441847
55Acute myeloid leukemia_Homo sapiens_hsa052211.08612220
56Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.08219413
57Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.06962793
58Tryptophan metabolism_Homo sapiens_hsa003801.06842626
59Shigellosis_Homo sapiens_hsa051311.06438353
60Adipocytokine signaling pathway_Homo sapiens_hsa049201.05951770
61Viral myocarditis_Homo sapiens_hsa054161.04859242
62Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.02178983
63Sulfur metabolism_Homo sapiens_hsa009200.97180723
64Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.96845516
65Prolactin signaling pathway_Homo sapiens_hsa049170.94931170
66T cell receptor signaling pathway_Homo sapiens_hsa046600.94358571
67Apoptosis_Homo sapiens_hsa042100.88891454
68Mineral absorption_Homo sapiens_hsa049780.86005326
69Leukocyte transendothelial migration_Homo sapiens_hsa046700.81401306
70Histidine metabolism_Homo sapiens_hsa003400.80644151
71Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.78313937
72Pancreatic cancer_Homo sapiens_hsa052120.76471642
73Steroid hormone biosynthesis_Homo sapiens_hsa001400.76447164
74Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.75523593
75Peroxisome_Homo sapiens_hsa041460.75220760
76Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.74911519
77Type II diabetes mellitus_Homo sapiens_hsa049300.74297621
78Glucagon signaling pathway_Homo sapiens_hsa049220.73629348
79alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.72774110
80Renin secretion_Homo sapiens_hsa049240.71053344
81Insulin resistance_Homo sapiens_hsa049310.70758941
82Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.69649518
83Sphingolipid metabolism_Homo sapiens_hsa006000.68791138
84Lysosome_Homo sapiens_hsa041420.68552066
85Selenocompound metabolism_Homo sapiens_hsa004500.68370719
86Chronic myeloid leukemia_Homo sapiens_hsa052200.67549445
87Glycosaminoglycan degradation_Homo sapiens_hsa005310.67387247
88Sphingolipid signaling pathway_Homo sapiens_hsa040710.66578753
89Osteoclast differentiation_Homo sapiens_hsa043800.65748594
90Toll-like receptor signaling pathway_Homo sapiens_hsa046200.63268546
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.62417572
92Neurotrophin signaling pathway_Homo sapiens_hsa047220.62040811
93Non-small cell lung cancer_Homo sapiens_hsa052230.62011493
94Synaptic vesicle cycle_Homo sapiens_hsa047210.60994155
95Vitamin digestion and absorption_Homo sapiens_hsa049770.60849212
96Phenylalanine metabolism_Homo sapiens_hsa003600.59963364
97Epstein-Barr virus infection_Homo sapiens_hsa051690.59731559
98Drug metabolism - other enzymes_Homo sapiens_hsa009830.58835103
99Primary immunodeficiency_Homo sapiens_hsa053400.58804270
100Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57862678
101Toxoplasmosis_Homo sapiens_hsa051450.56949760
102Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.56825024
103Prion diseases_Homo sapiens_hsa050200.55687013
104Butanoate metabolism_Homo sapiens_hsa006500.54485432
105Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.53498549
106Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.53296765
107Glycerophospholipid metabolism_Homo sapiens_hsa005640.53288840
108Viral carcinogenesis_Homo sapiens_hsa052030.52978791
109Fructose and mannose metabolism_Homo sapiens_hsa000510.52511225
110Vitamin B6 metabolism_Homo sapiens_hsa007500.52481886
111Platelet activation_Homo sapiens_hsa046110.51683385
112Renal cell carcinoma_Homo sapiens_hsa052110.51569488
113FoxO signaling pathway_Homo sapiens_hsa040680.51163280
114Linoleic acid metabolism_Homo sapiens_hsa005910.50372628
115Bladder cancer_Homo sapiens_hsa052190.50003724
116Prostate cancer_Homo sapiens_hsa052150.48989189
117HIF-1 signaling pathway_Homo sapiens_hsa040660.48507480
118Carbon metabolism_Homo sapiens_hsa012000.48057303
119Central carbon metabolism in cancer_Homo sapiens_hsa052300.47136199
120Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.45874172
121Amoebiasis_Homo sapiens_hsa051460.45675842
122Leishmaniasis_Homo sapiens_hsa051400.45478581
123Small cell lung cancer_Homo sapiens_hsa052220.44961078
124Legionellosis_Homo sapiens_hsa051340.44549219
125Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.44036184
126Pertussis_Homo sapiens_hsa051330.43326791
127TNF signaling pathway_Homo sapiens_hsa046680.43285580
128Phagosome_Homo sapiens_hsa041450.41290749
129Renin-angiotensin system_Homo sapiens_hsa046140.40978633
130Tuberculosis_Homo sapiens_hsa051520.40479451
131beta-Alanine metabolism_Homo sapiens_hsa004100.40198323
132Olfactory transduction_Homo sapiens_hsa047400.39993943
133Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.39953718
134Transcriptional misregulation in cancer_Homo sapiens_hsa052020.39367995
135GnRH signaling pathway_Homo sapiens_hsa049120.38182195
136Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.38061961
137African trypanosomiasis_Homo sapiens_hsa051430.38004583
138B cell receptor signaling pathway_Homo sapiens_hsa046620.37577944
139Pentose phosphate pathway_Homo sapiens_hsa000300.37392958
140Salmonella infection_Homo sapiens_hsa051320.37390587
141Influenza A_Homo sapiens_hsa051640.37244924
142VEGF signaling pathway_Homo sapiens_hsa043700.37080978
143AMPK signaling pathway_Homo sapiens_hsa041520.36410290
144Inositol phosphate metabolism_Homo sapiens_hsa005620.36216050
145Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.35970864
146Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.35891108
147Galactose metabolism_Homo sapiens_hsa000520.35591679
148Malaria_Homo sapiens_hsa051440.35148739
149HTLV-I infection_Homo sapiens_hsa051660.34986578
150mTOR signaling pathway_Homo sapiens_hsa041500.34662349
151Phosphatidylinositol signaling system_Homo sapiens_hsa040700.34402889
152Fatty acid elongation_Homo sapiens_hsa000620.34330758
153Proteoglycans in cancer_Homo sapiens_hsa052050.33920619
154Vibrio cholerae infection_Homo sapiens_hsa051100.33762453
155Lysine degradation_Homo sapiens_hsa003100.33565559
156Steroid biosynthesis_Homo sapiens_hsa001000.33475921
157Gastric acid secretion_Homo sapiens_hsa049710.32418370
158Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.31851011
159Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.31103151
160Tyrosine metabolism_Homo sapiens_hsa003500.30653501
161Thyroid hormone synthesis_Homo sapiens_hsa049180.30267400
162Endometrial cancer_Homo sapiens_hsa052130.29574829
163Phospholipase D signaling pathway_Homo sapiens_hsa040720.29310955
164Hepatitis C_Homo sapiens_hsa051600.29288185
165Aldosterone synthesis and secretion_Homo sapiens_hsa049250.28616955
166Insulin signaling pathway_Homo sapiens_hsa049100.28144910
167Estrogen signaling pathway_Homo sapiens_hsa049150.27892018
168Endocytosis_Homo sapiens_hsa041440.27755729

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