TDRKH

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synapsis (GO:0007129)7.21396485
2positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.64856846
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.50709696
4chromosome organization involved in meiosis (GO:0070192)5.44925564
5* piRNA metabolic process (GO:0034587)5.44153885
6male meiosis I (GO:0007141)5.39211627
7synaptic vesicle maturation (GO:0016188)5.14747782
8synaptic vesicle exocytosis (GO:0016079)5.07005477
9glutamate secretion (GO:0014047)4.92147500
10meiosis I (GO:0007127)4.75496781
11locomotory exploration behavior (GO:0035641)4.71497600
12neuron cell-cell adhesion (GO:0007158)4.69887462
13regulation of synaptic vesicle exocytosis (GO:2000300)4.65167465
14vocalization behavior (GO:0071625)4.64969973
15positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.61854031
16* DNA methylation involved in gamete generation (GO:0043046)4.59195199
17layer formation in cerebral cortex (GO:0021819)4.55884031
18protein localization to synapse (GO:0035418)4.46163205
19* male meiosis (GO:0007140)4.44155264
20DNA synthesis involved in DNA repair (GO:0000731)4.43191721
21synaptonemal complex assembly (GO:0007130)4.38070083
22resolution of meiotic recombination intermediates (GO:0000712)4.33108916
23regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.28388402
24regulation of synaptic vesicle transport (GO:1902803)4.23627027
25synaptic vesicle docking involved in exocytosis (GO:0016081)4.07188262
26* meiotic nuclear division (GO:0007126)4.03605287
27regulation of glutamate receptor signaling pathway (GO:1900449)4.03496089
28synaptonemal complex organization (GO:0070193)4.03261659
29neurotransmitter secretion (GO:0007269)4.02988838
30protein localization to chromosome (GO:0034502)3.89210157
31exploration behavior (GO:0035640)3.80076707
32cerebellar Purkinje cell differentiation (GO:0021702)3.77557735
33regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.72804319
34meiotic chromosome segregation (GO:0045132)3.72082673
35meiotic cell cycle process (GO:1903046)3.68904257
36positive regulation of synapse maturation (GO:0090129)3.64819856
37neurotransmitter-gated ion channel clustering (GO:0072578)3.64288100
38neuronal action potential propagation (GO:0019227)3.63605480
39cell migration in hindbrain (GO:0021535)3.61911477
40synaptic transmission, glutamatergic (GO:0035249)3.61182853
41regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.59213194
42regulation of neuronal synaptic plasticity (GO:0048168)3.58443406
43G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.55439685
44glutamate receptor signaling pathway (GO:0007215)3.54724485
45ionotropic glutamate receptor signaling pathway (GO:0035235)3.54700971
46innervation (GO:0060384)3.53596159
47regulation of synapse structural plasticity (GO:0051823)3.53577345
48neuron-neuron synaptic transmission (GO:0007270)3.52188480
49proteasome assembly (GO:0043248)3.51644836
50synaptic vesicle endocytosis (GO:0048488)3.49252635
51gamma-aminobutyric acid transport (GO:0015812)3.47514718
52regulation of long-term neuronal synaptic plasticity (GO:0048169)3.45154804
53regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.44595838
54dendrite morphogenesis (GO:0048813)3.43243125
55negative regulation of microtubule polymerization (GO:0031115)3.39680415
56neuron recognition (GO:0008038)3.37736593
57response to pheromone (GO:0019236)3.36640679
58long-term memory (GO:0007616)3.29918161
59reciprocal meiotic recombination (GO:0007131)3.28962801
60reciprocal DNA recombination (GO:0035825)3.28962801
61membrane depolarization during action potential (GO:0086010)3.28907334
62neurotransmitter transport (GO:0006836)3.26930448
63mitotic sister chromatid cohesion (GO:0007064)3.26872070
64DNA double-strand break processing (GO:0000729)3.26707657
65dendritic spine morphogenesis (GO:0060997)3.25876631
66transmission of nerve impulse (GO:0019226)3.25270903
67histone H2A acetylation (GO:0043968)3.24886997
68regulation of meiosis I (GO:0060631)3.24538324
69membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.20913374
70regulation of synaptic transmission, glutamatergic (GO:0051966)3.20912149
71regulation of neurotransmitter secretion (GO:0046928)3.19917394
72postsynaptic membrane organization (GO:0001941)3.19419183
73proline transport (GO:0015824)3.15612703
74mitotic spindle checkpoint (GO:0071174)3.15440767
75negative regulation of synaptic transmission, GABAergic (GO:0032229)3.14969804
76cellular potassium ion homeostasis (GO:0030007)3.13887779
77positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.13360128
78mitotic spindle assembly checkpoint (GO:0007094)3.12890770
79substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.12016997
80substrate-independent telencephalic tangential migration (GO:0021826)3.12016997
81axonal fasciculation (GO:0007413)3.11870571
82negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.09258864
83negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.09258864
84negative regulation of mitotic sister chromatid segregation (GO:0033048)3.09258864
85negative regulation of mitotic sister chromatid separation (GO:2000816)3.09258864
86negative regulation of sister chromatid segregation (GO:0033046)3.09258864
87mating behavior (GO:0007617)3.07192064
88positive regulation of membrane potential (GO:0045838)3.07026738
89spindle assembly checkpoint (GO:0071173)3.04928213
90negative regulation of chromosome segregation (GO:0051985)3.04777695
91gamma-aminobutyric acid signaling pathway (GO:0007214)3.04317831
92positive regulation of synaptic transmission, GABAergic (GO:0032230)3.03372339
93spindle checkpoint (GO:0031577)3.02569849
94synapse assembly (GO:0007416)3.02365504
95central nervous system projection neuron axonogenesis (GO:0021952)3.02357201
96mitotic sister chromatid segregation (GO:0000070)3.02064238
97positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.00600695
98sister chromatid cohesion (GO:0007062)3.00144518
99regulation of neurotransmitter transport (GO:0051588)2.98623139
100DNA ligation (GO:0006266)2.98429389
101regulation of excitatory postsynaptic membrane potential (GO:0060079)2.98244653
102establishment of mitochondrion localization (GO:0051654)2.97883050
103activation of protein kinase A activity (GO:0034199)2.97118781
104regulation of coenzyme metabolic process (GO:0051196)2.96315167
105regulation of cofactor metabolic process (GO:0051193)2.96315167
106regulation of neurotransmitter levels (GO:0001505)2.96096743
107microtubule depolymerization (GO:0007019)2.95749213
108pyrimidine nucleobase catabolic process (GO:0006208)2.95192291
109sister chromatid segregation (GO:0000819)2.94553528
110regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.94249682
111cerebellar granule cell differentiation (GO:0021707)2.93877119
112regulation of vesicle fusion (GO:0031338)2.92898604
113regulation of postsynaptic membrane potential (GO:0060078)2.92294579
114histone exchange (GO:0043486)2.92184162
115organelle transport along microtubule (GO:0072384)2.92138383
116mitotic metaphase plate congression (GO:0007080)2.91112780
117positive regulation of dendritic spine morphogenesis (GO:0061003)2.90994827
118regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.90871377
119vesicle transport along microtubule (GO:0047496)2.90686746
120synaptic vesicle transport (GO:0048489)2.90655440
121establishment of synaptic vesicle localization (GO:0097480)2.90655440
122establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.88510481
123mitochondrion transport along microtubule (GO:0047497)2.88510481
124chromatin remodeling at centromere (GO:0031055)2.87691694
125CENP-A containing nucleosome assembly (GO:0034080)2.87250831
126DNA catabolic process, exonucleolytic (GO:0000738)2.86633354
127regulation of centriole replication (GO:0046599)2.86476920
128regulation of synaptic plasticity (GO:0048167)2.86076391
129long-term synaptic potentiation (GO:0060291)2.85879443
130prepulse inhibition (GO:0060134)2.85560959
131establishment of nucleus localization (GO:0040023)2.84694358
132regulation of synapse maturation (GO:0090128)2.84196154
133axon cargo transport (GO:0008088)2.83586215
134auditory behavior (GO:0031223)2.83494921
135response to auditory stimulus (GO:0010996)2.83328365
136presynaptic membrane assembly (GO:0097105)2.82050812
137negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.81196535
138behavioral defense response (GO:0002209)2.81187246
139behavioral fear response (GO:0001662)2.81187246
140regulation of chromosome segregation (GO:0051983)2.80424046
141striatum development (GO:0021756)2.80221891
142neuromuscular process controlling balance (GO:0050885)2.80117524
143regulation of calcium ion-dependent exocytosis (GO:0017158)2.77525605
144membrane hyperpolarization (GO:0060081)2.77518462
145cell differentiation in hindbrain (GO:0021533)2.75584531
146establishment of vesicle localization (GO:0051650)2.75259100
147membrane depolarization (GO:0051899)2.75133960
148synapse organization (GO:0050808)2.75064506
149regulation of dendritic spine morphogenesis (GO:0061001)2.73579450
150metaphase plate congression (GO:0051310)2.73332484
151negative regulation of DNA recombination (GO:0045910)2.73063860
152adult walking behavior (GO:0007628)2.72677899
153attachment of spindle microtubules to kinetochore (GO:0008608)2.71997083
154regulation of acyl-CoA biosynthetic process (GO:0050812)2.71408082
155regulation of double-strand break repair via homologous recombination (GO:0010569)2.70844088
156protein localization to chromosome, centromeric region (GO:0071459)2.70587608
157protein localization to kinetochore (GO:0034501)2.69020167
158regulation of mitotic sister chromatid separation (GO:0010965)2.68638677
159regulation of mitotic sister chromatid segregation (GO:0033047)2.68638677
160regulation of sister chromatid segregation (GO:0033045)2.68638677
161cholesterol biosynthetic process (GO:0006695)2.66586163
162intraciliary transport (GO:0042073)2.66304583
163regulation of mitotic metaphase/anaphase transition (GO:0030071)2.62864071
164regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.62864071
165de novo posttranslational protein folding (GO:0051084)2.62355961
166* gene silencing by RNA (GO:0031047)2.61735915
167regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.61351728
168somatic hypermutation of immunoglobulin genes (GO:0016446)2.58966149
169somatic diversification of immune receptors via somatic mutation (GO:0002566)2.58966149
170de novo protein folding (GO:0006458)2.58851154
171anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.58027555
172ATP-dependent chromatin remodeling (GO:0043044)2.57680622
173mitotic chromosome condensation (GO:0007076)2.57629487
174binding of sperm to zona pellucida (GO:0007339)2.55292638
175non-recombinational repair (GO:0000726)2.55268570
176double-strand break repair via nonhomologous end joining (GO:0006303)2.55268570
177establishment of integrated proviral latency (GO:0075713)2.54521709
178protein K6-linked ubiquitination (GO:0085020)2.51121229
179base-excision repair, AP site formation (GO:0006285)2.50061797
180ribonucleoprotein complex disassembly (GO:0032988)2.50024821
181sterol biosynthetic process (GO:0016126)2.49725349
182protein K11-linked ubiquitination (GO:0070979)2.49075202
183positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.48165548
184sequestering of actin monomers (GO:0042989)2.46796912
185nuclear pore complex assembly (GO:0051292)2.46652219
186tricarboxylic acid cycle (GO:0006099)2.46393924
187metallo-sulfur cluster assembly (GO:0031163)2.46286618
188iron-sulfur cluster assembly (GO:0016226)2.46286618
189negative regulation of meiosis (GO:0045835)2.46277928
190kinetochore organization (GO:0051383)2.46070415
191isoprenoid biosynthetic process (GO:0008299)2.45739665
192negative regulation of nuclear division (GO:0051784)2.44566006
193neural tube formation (GO:0001841)2.44405165
194negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.43836089
195nonmotile primary cilium assembly (GO:0035058)2.42450406
196negative regulation of mitosis (GO:0045839)2.42100780
197peptidyl-arginine omega-N-methylation (GO:0035247)2.39815490
198DNA replication-independent nucleosome organization (GO:0034724)2.39321487
199DNA replication-independent nucleosome assembly (GO:0006336)2.39321487

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.78028890
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.35549265
3MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.91779374
4E2F7_22180533_ChIP-Seq_HELA_Human3.79020883
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.59757062
6GBX2_23144817_ChIP-Seq_PC3_Human3.45633615
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.36128344
8FOXM1_23109430_ChIP-Seq_U2OS_Human3.08921395
9E2F4_17652178_ChIP-ChIP_JURKAT_Human2.89268719
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.87874423
11REST_21632747_ChIP-Seq_MESCs_Mouse2.86574428
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.76686373
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.74456969
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.67020390
15SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.66204927
16JARID2_20064375_ChIP-Seq_MESCs_Mouse2.63528970
17JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.62267608
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.61624050
19NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.56168410
20CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.51282129
21ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.49474165
22SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.44509099
23ETS1_20019798_ChIP-Seq_JURKAT_Human2.43089521
24SALL1_21062744_ChIP-ChIP_HESCs_Human2.41821932
25REST_18959480_ChIP-ChIP_MESCs_Mouse2.40678789
26THAP11_20581084_ChIP-Seq_MESCs_Mouse2.40116976
27EZH2_27304074_Chip-Seq_ESCs_Mouse2.39436510
28RARB_27405468_Chip-Seq_BRAIN_Mouse2.39092661
29HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.38587701
30PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.37973315
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.36695690
32JARID2_20075857_ChIP-Seq_MESCs_Mouse2.26596393
33PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.26373704
34EZH2_18974828_ChIP-Seq_MESCs_Mouse2.26186555
35RNF2_18974828_ChIP-Seq_MESCs_Mouse2.26186555
36HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.25225832
37DROSHA_22980978_ChIP-Seq_HELA_Human2.24851164
38SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.19108832
39CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.14070300
40MYC_18555785_ChIP-Seq_MESCs_Mouse2.12901907
41* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.11608989
42SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.08332051
43SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.08275140
44RNF2_27304074_Chip-Seq_ESCs_Mouse2.07242897
45EZH2_27294783_Chip-Seq_ESCs_Mouse2.06202952
46SUZ12_27294783_Chip-Seq_ESCs_Mouse2.04843627
47TAF15_26573619_Chip-Seq_HEK293_Human2.00045652
48KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.99635622
49CTBP2_25329375_ChIP-Seq_LNCAP_Human1.97797472
50DCP1A_22483619_ChIP-Seq_HELA_Human1.95071507
51GABP_19822575_ChIP-Seq_HepG2_Human1.95016498
52POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.93996587
53MYCN_18555785_ChIP-Seq_MESCs_Mouse1.92255685
54SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.92036862
55IGF1R_20145208_ChIP-Seq_DFB_Human1.89165536
56SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.87145540
57EED_16625203_ChIP-ChIP_MESCs_Mouse1.81965822
58NELFA_20434984_ChIP-Seq_ESCs_Mouse1.81756557
59PADI4_21655091_ChIP-ChIP_MCF-7_Human1.81372460
60YY1_21170310_ChIP-Seq_MESCs_Mouse1.80289199
61CTBP1_25329375_ChIP-Seq_LNCAP_Human1.79376431
62ELK1_19687146_ChIP-ChIP_HELA_Human1.77772242
63* XRN2_22483619_ChIP-Seq_HELA_Human1.76428864
64ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.73617800
65SMAD4_21799915_ChIP-Seq_A2780_Human1.71655120
66MYC_19030024_ChIP-ChIP_MESCs_Mouse1.71186624
67VDR_23849224_ChIP-Seq_CD4+_Human1.70752360
68FOXP3_21729870_ChIP-Seq_TREG_Human1.69859545
69VDR_22108803_ChIP-Seq_LS180_Human1.68519069
70MYC_18358816_ChIP-ChIP_MESCs_Mouse1.65666410
71YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.65422040
72* RNF2_27304074_Chip-Seq_NSC_Mouse1.64829476
73* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.64273793
74AR_21572438_ChIP-Seq_LNCaP_Human1.63738977
75PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.62201488
76CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.61972883
77* KDM5A_27292631_Chip-Seq_BREAST_Human1.61414646
78TTF2_22483619_ChIP-Seq_HELA_Human1.61272931
79FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.61148086
80EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.60925256
81MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.60375541
82E2F1_18555785_ChIP-Seq_MESCs_Mouse1.58204622
83IKZF1_21737484_ChIP-ChIP_HCT116_Human1.56001000
84PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.55971070
85CBX2_27304074_Chip-Seq_ESCs_Mouse1.54421305
86ZNF274_21170338_ChIP-Seq_K562_Hela1.54375786
87MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.52652028
88ZFX_18555785_ChIP-Seq_MESCs_Mouse1.47309394
89ZFP57_27257070_Chip-Seq_ESCs_Mouse1.46448244
90* STAT3_23295773_ChIP-Seq_U87_Human1.46047997
91CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.44785247
92MYC_19079543_ChIP-ChIP_MESCs_Mouse1.44632952
93RBPJ_22232070_ChIP-Seq_NCS_Mouse1.44560033
94SOX2_21211035_ChIP-Seq_LN229_Gbm1.44492111
95P300_19829295_ChIP-Seq_ESCs_Human1.44470805
96FUS_26573619_Chip-Seq_HEK293_Human1.42932519
97POU3F2_20337985_ChIP-ChIP_501MEL_Human1.41322430
98E2F1_21310950_ChIP-Seq_MCF-7_Human1.39781435
99SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.35009229
100* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.33653448
101TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.33425098
102MYC_18940864_ChIP-ChIP_HL60_Human1.31891898
103RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.31494408
104GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30366633
105SMAD3_21741376_ChIP-Seq_EPCs_Human1.29874024
106TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28252589
107PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.27467298
108SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26477699
109OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25473852
110TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24804787
111POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.24804787
112TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.24440614
113IRF1_19129219_ChIP-ChIP_H3396_Human1.23959765
114* TCF4_23295773_ChIP-Seq_U87_Human1.23250273
115NR3C1_23031785_ChIP-Seq_PC12_Mouse1.23107250
116* CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.22710608
117BMI1_23680149_ChIP-Seq_NPCS_Mouse1.22233233
118RING1B_27294783_Chip-Seq_ESCs_Mouse1.21245685
119HOXB4_20404135_ChIP-ChIP_EML_Mouse1.20212580
120TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.19572747
121PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.19430390
122EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.19247598
123SMAD3_21741376_ChIP-Seq_ESCs_Human1.18811314
124YAP1_20516196_ChIP-Seq_MESCs_Mouse1.18765516
125AR_25329375_ChIP-Seq_VCAP_Human1.18743768
126ESR1_15608294_ChIP-ChIP_MCF-7_Human1.18208879
127AR_19668381_ChIP-Seq_PC3_Human1.17844248
128P53_22127205_ChIP-Seq_FIBROBLAST_Human1.17747296
129SOX2_18555785_ChIP-Seq_MESCs_Mouse1.17127241
130SOX2_16153702_ChIP-ChIP_HESCs_Human1.16481806
131RING1B_27294783_Chip-Seq_NPCs_Mouse1.15716701
132* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.14735363
133MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.13387700
134SRF_21415370_ChIP-Seq_HL-1_Mouse1.12160494
135TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11103083
136MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.11099797
137FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.08816764
138AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.07538143
139ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.05494952
140DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.05237378
141SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.03262986
142REST_19997604_ChIP-ChIP_NEURONS_Mouse1.03098073
143ER_23166858_ChIP-Seq_MCF-7_Human1.02327496
144AR_21909140_ChIP-Seq_LNCAP_Human1.02052007
145NANOG_18555785_ChIP-Seq_MESCs_Mouse1.01733606
146TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.01217919
147ERG_21242973_ChIP-ChIP_JURKAT_Human1.00339477
148BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.99834259
149BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.99731817
150* SOX9_26525672_Chip-Seq_HEART_Mouse0.99731351
151RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.98684367
152RUNX2_22187159_ChIP-Seq_PCA_Human0.97881875
153TP53_22573176_ChIP-Seq_HFKS_Human0.97709839
154CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97009974
155PIAS1_25552417_ChIP-Seq_VCAP_Human0.96807175
156RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.96205824
157NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95245207
158OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.95002702
159GATA1_26923725_Chip-Seq_HPCs_Mouse0.94641105
160WT1_25993318_ChIP-Seq_PODOCYTE_Human0.94166577
161GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.92727172
162NANOG_18555785_Chip-Seq_ESCs_Mouse0.91200169
163PRDM14_20953172_ChIP-Seq_ESCs_Human0.91085180
164NANOG_16153702_ChIP-ChIP_HESCs_Human0.90491238
165SMAD_19615063_ChIP-ChIP_OVARY_Human0.89489609
166EWS_26573619_Chip-Seq_HEK293_Human0.89477824
167MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.89329434
168TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88739645
169SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.88717489
170CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.88278426
171JUN_21703547_ChIP-Seq_K562_Human0.88115344
172TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.87366774
173ELK4_26923725_Chip-Seq_MESODERM_Mouse0.86910437
174TET1_21490601_ChIP-Seq_MESCs_Mouse0.86466496
175ARNT_22903824_ChIP-Seq_MCF-7_Human0.85658460
176NANOG_21062744_ChIP-ChIP_HESCs_Human0.84061850
177POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.83895120
178POU5F1_16153702_ChIP-ChIP_HESCs_Human0.83041957
179PKCTHETA_26484144_Chip-Seq_BREAST_Human0.81416940
180DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.78327257

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.11162038
2MP0003635_abnormal_synaptic_transmissio3.55144581
3MP0003880_abnormal_central_pattern3.52936328
4MP0004270_analgesia3.49711549
5MP0008058_abnormal_DNA_repair3.09541327
6MP0002063_abnormal_learning/memory/cond2.85973381
7MP0009745_abnormal_behavioral_response2.78649950
8MP0002064_seizures2.66185091
9MP0005423_abnormal_somatic_nervous2.65360717
10MP0009046_muscle_twitch2.62122081
11MP0002734_abnormal_mechanical_nocicepti2.56152037
12MP0001968_abnormal_touch/_nociception2.55652407
13MP0003693_abnormal_embryo_hatching2.54918906
14MP0002572_abnormal_emotion/affect_behav2.44921644
15MP0008877_abnormal_DNA_methylation2.35488052
16MP0002735_abnormal_chemical_nociception2.31382288
17MP0000569_abnormal_digit_pigmentation2.30748033
18MP0002272_abnormal_nervous_system2.27489364
19MP0001486_abnormal_startle_reflex2.25343028
20MP0000778_abnormal_nervous_system2.24000361
21MP0003787_abnormal_imprinting2.21338124
22MP0006276_abnormal_autonomic_nervous2.07040528
23MP0002184_abnormal_innervation2.07001245
24MP0002736_abnormal_nociception_after1.98925343
25MP0002067_abnormal_sensory_capabilities1.98701028
26MP0001984_abnormal_olfaction1.97842068
27MP0002733_abnormal_thermal_nociception1.97143335
28MP0001529_abnormal_vocalization1.95597013
29MP0003111_abnormal_nucleus_morphology1.92072548
30MP0005646_abnormal_pituitary_gland1.87965941
31MP0004811_abnormal_neuron_physiology1.87477955
32MP0005551_abnormal_eye_electrophysiolog1.85901033
33MP0008932_abnormal_embryonic_tissue1.85785271
34MP0010094_abnormal_chromosome_stability1.85575789
35MP0003718_maternal_effect1.83629911
36MP0004924_abnormal_behavior1.80143580
37MP0005386_behavior/neurological_phenoty1.80143580
38MP0002557_abnormal_social/conspecific_i1.79782296
39MP0001145_abnormal_male_reproductive1.78742974
40MP0001970_abnormal_pain_threshold1.76698463
41MP0001440_abnormal_grooming_behavior1.74554459
42MP0008569_lethality_at_weaning1.71749996
43MP0000955_abnormal_spinal_cord1.70753368
44MP0001502_abnormal_circadian_rhythm1.68365722
45MP0002822_catalepsy1.67282221
46MP0002882_abnormal_neuron_morphology1.64684801
47MP0001501_abnormal_sleep_pattern1.64092873
48MP0008789_abnormal_olfactory_epithelium1.63887311
49MP0003077_abnormal_cell_cycle1.62639428
50MP0004957_abnormal_blastocyst_morpholog1.61011847
51MP0000653_abnormal_sex_gland1.60753908
52MP0008995_early_reproductive_senescence1.60428339
53MP0003122_maternal_imprinting1.58852607
54MP0008057_abnormal_DNA_replication1.57726609
55MP0006072_abnormal_retinal_apoptosis1.56628489
56MP0004885_abnormal_endolymph1.53469102
57MP0006035_abnormal_mitochondrial_morpho1.49121368
58MP0002909_abnormal_adrenal_gland1.43683015
59MP0002160_abnormal_reproductive_system1.42966693
60MP0009780_abnormal_chondrocyte_physiolo1.42522306
61MP0002638_abnormal_pupillary_reflex1.40498414
62MP0001905_abnormal_dopamine_level1.39304211
63MP0004147_increased_porphyrin_level1.38973629
64MP0004142_abnormal_muscle_tone1.37662863
65MP0002066_abnormal_motor_capabilities/c1.36780602
66MP0002152_abnormal_brain_morphology1.36404537
67MP0001188_hyperpigmentation1.34594976
68MP0000631_abnormal_neuroendocrine_gland1.31695924
69MP0005645_abnormal_hypothalamus_physiol1.31189267
70MP0004858_abnormal_nervous_system1.30655743
71MP0003121_genomic_imprinting1.30321299
72MP0000647_abnormal_sebaceous_gland1.28672469
73MP0002229_neurodegeneration1.23614546
74MP0003329_amyloid_beta_deposits1.22045977
75MP0003119_abnormal_digestive_system1.18797229
76MP0003937_abnormal_limbs/digits/tail_de1.18004628
77MP0005253_abnormal_eye_physiology1.16372375
78MP0002752_abnormal_somatic_nervous1.15085450
79MP0009672_abnormal_birth_weight1.12964070
80MP0003011_delayed_dark_adaptation1.11984314
81MP0010386_abnormal_urinary_bladder1.10089310
82MP0006292_abnormal_olfactory_placode1.09858698
83MP0005389_reproductive_system_phenotype1.05775283
84MP0004742_abnormal_vestibular_system1.05570904
85MP0003786_premature_aging1.04892770
86MP0002653_abnormal_ependyma_morphology1.04068243
87MP0003879_abnormal_hair_cell1.03149482
88MP0000358_abnormal_cell_content/1.03120535
89MP0002090_abnormal_vision1.02910620
90MP0003878_abnormal_ear_physiology1.01798471
91MP0005377_hearing/vestibular/ear_phenot1.01798471
92MP0005394_taste/olfaction_phenotype1.01680513
93MP0005499_abnormal_olfactory_system1.01680513
94MP0003698_abnormal_male_reproductive1.01385982
95MP0003861_abnormal_nervous_system0.99507917
96MP0002751_abnormal_autonomic_nervous0.99379080
97MP0003890_abnormal_embryonic-extraembry0.98764727
98MP0003634_abnormal_glial_cell0.98345190
99MP0000537_abnormal_urethra_morphology0.95926994
100MP0003632_abnormal_nervous_system0.92889329
101MP0001730_embryonic_growth_arrest0.90549816
102MP0008007_abnormal_cellular_replicative0.90546925
103MP0004233_abnormal_muscle_weight0.88261416
104MP0003631_nervous_system_phenotype0.87825392
105MP0009703_decreased_birth_body0.87399959
106MP0002069_abnormal_eating/drinking_beha0.87242432
107MP0001727_abnormal_embryo_implantation0.86438201
108MP0001919_abnormal_reproductive_system0.85359278
109MP0002084_abnormal_developmental_patter0.85046747
110MP0010234_abnormal_vibrissa_follicle0.84631017
111MP0004197_abnormal_fetal_growth/weight/0.84019710
112MP0001119_abnormal_female_reproductive0.84012994
113MP0001963_abnormal_hearing_physiology0.83501643
114MP0003938_abnormal_ear_development0.83480740
115MP0001299_abnormal_eye_distance/0.82889101
116MP0003633_abnormal_nervous_system0.82117800
117MP0003123_paternal_imprinting0.81763100
118MP0005195_abnormal_posterior_eye0.80811010
119MP0000751_myopathy0.80091397
120MP0005410_abnormal_fertilization0.77391343
121MP0004133_heterotaxia0.77269997
122MP0001697_abnormal_embryo_size0.76125452
123MP0001929_abnormal_gametogenesis0.75688391
124MP0001672_abnormal_embryogenesis/_devel0.75290596
125MP0005380_embryogenesis_phenotype0.75290596
126MP0005248_abnormal_Harderian_gland0.74053813
127MP0004145_abnormal_muscle_electrophysio0.73875289
128MP0001485_abnormal_pinna_reflex0.73430260
129MP0001177_atelectasis0.70927227
130MP0005187_abnormal_penis_morphology0.69471976
131MP0001986_abnormal_taste_sensitivity0.69021018
132MP0005171_absent_coat_pigmentation0.67275036
133MP0002102_abnormal_ear_morphology0.66273025
134MP0010770_preweaning_lethality0.65618105
135MP0002082_postnatal_lethality0.65618105
136MP0002161_abnormal_fertility/fecundity0.65305015
137MP0008961_abnormal_basal_metabolism0.65001528
138MP0002210_abnormal_sex_determination0.64684302
139MP0010769_abnormal_survival0.64645465
140MP0010768_mortality/aging0.62678607
141MP0003183_abnormal_peptide_metabolism0.61855884
142MP0004085_abnormal_heartbeat0.60203626

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.96024429
2Myokymia (HP:0002411)4.81064143
3Abnormality of the labia minora (HP:0012880)4.21727879
4Visual hallucinations (HP:0002367)4.17628910
5Focal seizures (HP:0007359)4.10297335
6Epileptic encephalopathy (HP:0200134)4.09480384
7Cortical dysplasia (HP:0002539)3.99289107
8Progressive cerebellar ataxia (HP:0002073)3.87376227
9Febrile seizures (HP:0002373)3.60020876
10Atonic seizures (HP:0010819)3.53740188
11Abnormality of the lower motor neuron (HP:0002366)3.21665483
12Action tremor (HP:0002345)3.17441558
13Absence seizures (HP:0002121)3.15491604
14Oligodactyly (hands) (HP:0001180)3.04627571
15Dialeptic seizures (HP:0011146)2.97139708
16Degeneration of the lateral corticospinal tracts (HP:0002314)2.87602712
17Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.87602712
18Supranuclear gaze palsy (HP:0000605)2.82538964
19Pheochromocytoma (HP:0002666)2.82491484
20Gaze-evoked nystagmus (HP:0000640)2.82209553
21Ankle clonus (HP:0011448)2.81806195
22Generalized tonic-clonic seizures (HP:0002069)2.78382685
23Amyotrophic lateral sclerosis (HP:0007354)2.76734999
24Limb dystonia (HP:0002451)2.76420945
25Volvulus (HP:0002580)2.73406846
26Gonadotropin excess (HP:0000837)2.72529662
27Upper limb muscle weakness (HP:0003484)2.71146147
28Broad-based gait (HP:0002136)2.68810249
29Ependymoma (HP:0002888)2.65170059
30Drooling (HP:0002307)2.63771587
31Excessive salivation (HP:0003781)2.63771587
32Type II lissencephaly (HP:0007260)2.57557136
33Depression (HP:0000716)2.57115809
34Progressive inability to walk (HP:0002505)2.57037901
35Genetic anticipation (HP:0003743)2.56855534
36Dysdiadochokinesis (HP:0002075)2.56729576
37Truncal ataxia (HP:0002078)2.54828234
38Central scotoma (HP:0000603)2.54347300
39Gait imbalance (HP:0002141)2.53269127
40Urinary bladder sphincter dysfunction (HP:0002839)2.50469870
41Rimmed vacuoles (HP:0003805)2.47916865
42Insidious onset (HP:0003587)2.44088605
43Termporal pattern (HP:0011008)2.44088605
44Neuroendocrine neoplasm (HP:0100634)2.41708085
45Mutism (HP:0002300)2.41402666
46Colon cancer (HP:0003003)2.40995348
47Failure to thrive in infancy (HP:0001531)2.40495211
48Impaired vibration sensation in the lower limbs (HP:0002166)2.39108088
49Abnormality of the corticospinal tract (HP:0002492)2.36719910
50Papilledema (HP:0001085)2.36103725
51Abnormal eating behavior (HP:0100738)2.35936497
52Poor eye contact (HP:0000817)2.34489992
53Megalencephaly (HP:0001355)2.32227654
54Spastic gait (HP:0002064)2.32180752
55Epileptiform EEG discharges (HP:0011182)2.31237722
56Hyperventilation (HP:0002883)2.31148167
57Urinary urgency (HP:0000012)2.29788816
58Retinal dysplasia (HP:0007973)2.29317518
59Lissencephaly (HP:0001339)2.26619628
60EEG with generalized epileptiform discharges (HP:0011198)2.26494553
61Aplasia/Hypoplasia of the brainstem (HP:0007362)2.26185335
62Hypoplasia of the brainstem (HP:0002365)2.26185335
63Impaired smooth pursuit (HP:0007772)2.24827751
64Increased nuchal translucency (HP:0010880)2.24741006
65Pendular nystagmus (HP:0012043)2.24471630
66Amblyopia (HP:0000646)2.24468789
67Congenital stationary night blindness (HP:0007642)2.23167841
68Abnormality of the astrocytes (HP:0100707)2.22553611
69Astrocytoma (HP:0009592)2.22553611
70Abnormality of ocular smooth pursuit (HP:0000617)2.21781666
71Oligodactyly (HP:0012165)2.20208407
72Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.19775565
73Agitation (HP:0000713)2.19585987
74Postural instability (HP:0002172)2.18700934
75Abnormal mitochondria in muscle tissue (HP:0008316)2.17057846
76Congenital primary aphakia (HP:0007707)2.17014871
77Abnormality of macular pigmentation (HP:0008002)2.15640653
78Hypsarrhythmia (HP:0002521)2.15523638
79Esotropia (HP:0000565)2.14328785
80Poor suck (HP:0002033)2.13201092
81Dysmetria (HP:0001310)2.12472432
82Abnormal social behavior (HP:0012433)2.12306414
83Impaired social interactions (HP:0000735)2.12306414
84Insomnia (HP:0100785)2.11861510
85Hypoplastic female external genitalia (HP:0012815)2.11631665
86Protruding tongue (HP:0010808)2.10770868
87Abnormal lung lobation (HP:0002101)2.09855895
88Anxiety (HP:0000739)2.07996555
89Labial hypoplasia (HP:0000066)2.07822993
90Abnormal hair whorl (HP:0010721)2.07151237
91Chromosomal breakage induced by crosslinking agents (HP:0003221)2.06439868
92Polyphagia (HP:0002591)2.05988340
93Specific learning disability (HP:0001328)2.04466704
94Medial flaring of the eyebrow (HP:0010747)2.03665790
95Scanning speech (HP:0002168)2.03362590
96Papillary thyroid carcinoma (HP:0002895)2.03269079
97Nephroblastoma (Wilms tumor) (HP:0002667)2.03235707
98Atrophy/Degeneration involving motor neurons (HP:0007373)2.02574973
99Abnormality of glycolysis (HP:0004366)2.02539184
100Hemiparesis (HP:0001269)1.98718080
101Increased serum pyruvate (HP:0003542)1.98350568
102CNS hypomyelination (HP:0003429)1.97476955
103Pachygyria (HP:0001302)1.97336452
104Shoulder girdle muscle weakness (HP:0003547)1.96738139
105Abnormality of the labia (HP:0000058)1.95244533
106Absent speech (HP:0001344)1.94661216
107Embryonal renal neoplasm (HP:0011794)1.93266517
108Neoplasm of the peripheral nervous system (HP:0100007)1.92052798
109Aplasia/Hypoplasia of the uvula (HP:0010293)1.91781105
110Nephrogenic diabetes insipidus (HP:0009806)1.91539560
111Abnormality of midbrain morphology (HP:0002418)1.91439446
112Molar tooth sign on MRI (HP:0002419)1.91439446
113Brushfield spots (HP:0001088)1.88721920
114Glioma (HP:0009733)1.88576843
115Inability to walk (HP:0002540)1.87549884
116Inappropriate behavior (HP:0000719)1.86689864
117Chromsome breakage (HP:0040012)1.86425539
118Acute necrotizing encephalopathy (HP:0006965)1.85420658
119Postnatal microcephaly (HP:0005484)1.85113787
120Meckel diverticulum (HP:0002245)1.84070701
121Blue irides (HP:0000635)1.83727770
122Spastic tetraplegia (HP:0002510)1.83266767
123Bradykinesia (HP:0002067)1.83036813
124Stereotypic behavior (HP:0000733)1.82253856
125Spastic diplegia (HP:0001264)1.81465293
126Hyperacusis (HP:0010780)1.80614325
127Rhabdomyosarcoma (HP:0002859)1.80478900
128Lower limb muscle weakness (HP:0007340)1.79050127
129Medulloblastoma (HP:0002885)1.78439429
130Acute encephalopathy (HP:0006846)1.78349377
131Neoplasm of the adrenal gland (HP:0100631)1.78100241
132Gait ataxia (HP:0002066)1.77668796
133Pointed chin (HP:0000307)1.77273699
134Generalized hypotonia (HP:0001290)1.77099962
135Vaginal atresia (HP:0000148)1.76746903
136Proximal placement of thumb (HP:0009623)1.76482616
137Genital tract atresia (HP:0001827)1.76188099
138Abnormality of the ileum (HP:0001549)1.75196174
139Scotoma (HP:0000575)1.75123220
140Severe visual impairment (HP:0001141)1.75066603
141Aplasia/Hypoplasia of the sternum (HP:0006714)1.75028364
142Abnormality of chromosome stability (HP:0003220)1.74814580
143Dynein arm defect of respiratory motile cilia (HP:0012255)1.74768164
144Absent/shortened dynein arms (HP:0200106)1.74768164
145Duodenal stenosis (HP:0100867)1.74692759
146Small intestinal stenosis (HP:0012848)1.74692759
147Degeneration of anterior horn cells (HP:0002398)1.73995815
148Abnormality of the anterior horn cell (HP:0006802)1.73995815
149Fetal akinesia sequence (HP:0001989)1.72758480
150Abnormality of the hip-girdle musculature (HP:0001445)1.72744932
151Abnormality of the musculature of the pelvis (HP:0001469)1.72744932
152Neoplasm of the heart (HP:0100544)1.72429086
153Morphological abnormality of the pyramidal tract (HP:0002062)1.71887014
154Akinesia (HP:0002304)1.71362037
155Pelvic girdle muscle weakness (HP:0003749)1.70684294
156Clonus (HP:0002169)1.69603201
157Hyperglycinemia (HP:0002154)1.69356966
158Peripheral hypomyelination (HP:0007182)1.67683823
159Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.65633618
160Decreased activity of mitochondrial respiratory chain (HP:0008972)1.65633618
161Thyroid carcinoma (HP:0002890)1.63532474
162Horizontal nystagmus (HP:0000666)1.63421957
163Azoospermia (HP:0000027)1.60155748
164Hepatic necrosis (HP:0002605)1.59920365
165Embryonal neoplasm (HP:0002898)1.57664712
166Abnormality of the preputium (HP:0100587)1.57536270
167Hyperalaninemia (HP:0003348)1.57020936

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.52088083
2MARK14.51044333
3BUB13.42913618
4MAP3K43.23677722
5MAP3K93.15304803
6MINK12.89618675
7MAP2K72.59774722
8TTK2.50741243
9PAK62.43783764
10CASK2.40274426
11TESK22.36195739
12SRPK12.21764063
13TSSK62.20033281
14NTRK22.18823676
15MAPK132.12175214
16KSR11.88207502
17EPHA41.88031537
18TRIM281.85481690
19PRKD31.75276444
20CCNB11.73304471
21CSNK1G11.73035401
22UHMK11.71973687
23TNIK1.67273611
24NUAK11.64163047
25BRSK11.60890754
26MAP2K41.60187252
27STK38L1.58256120
28KSR21.56439298
29PRPF4B1.48720601
30PLK21.48633897
31PLK41.43377609
32PHKG11.41737802
33PHKG21.41737802
34CDK51.41397622
35DAPK21.41363564
36PLK11.41177383
37EIF2AK31.39197376
38VRK21.37412239
39BRSK21.35053657
40MST41.33553961
41PINK11.31828192
42CDC71.31795227
43NTRK11.31052364
44DYRK31.30054455
45CAMKK11.28778505
46ZAK1.28490534
47ARAF1.23545214
48EIF2AK11.21844108
49SGK4941.19926876
50SGK2231.19926876
51TYRO31.19784192
52TESK11.16035579
53CSNK1G21.15722710
54PDK21.11801737
55PBK1.11638387
56PNCK1.10514372
57MAP3K121.09639810
58ATR1.08124186
59NEK21.07389012
60CDK181.07366118
61CDK141.06018589
62MAP4K21.05625265
63ERBB31.05574601
64RET1.05106069
65BCR1.03951370
66PRKCG1.03210103
67SGK21.03077386
68CDK151.01706937
69BRAF1.01469747
70DAPK10.97824116
71MUSK0.97115771
72WEE10.93662944
73CDK190.91305802
74DYRK20.91284512
75IRAK20.90333261
76STK380.89199574
77CDK11A0.88655242
78DYRK1A0.88007833
79LATS20.85427340
80CHEK10.84393135
81CAMKK20.84069562
82AURKA0.83989832
83VRK10.82539227
84RPS6KA40.80470919
85MAP3K20.78990358
86SIK30.75720573
87CAMK2A0.75528957
88FES0.75434315
89NEK10.75068042
90SIK20.72553748
91CSNK1G30.72461080
92STK160.71741339
93PLK30.71157093
94SGK30.70413849
95PRKCI0.69494768
96PDK40.69101089
97PDK30.69101089
98MET0.68931476
99ATM0.68834273
100GRK50.68549812
101MAP3K60.66737573
102TAF10.66335046
103STK110.65543835
104CDC42BPA0.65265013
105LIMK10.65113278
106CSNK1E0.62883729
107PAK30.61681697
108AURKB0.61018377
109RPS6KA50.60451070
110CHEK20.59433665
111BCKDK0.59070826
112CDK80.58501517
113CAMK2B0.58490159
114BMPR1B0.58229259
115SGK10.58206577
116CSNK1A1L0.57750435
117OXSR10.56560438
118NME10.55786207
119FER0.54975206
120CDK10.53609549
121ICK0.53238977
122BRD40.52897170
123CAMK1D0.52552512
124RPS6KA20.52426357
125WNK10.51010617
126RPS6KA30.49861353
127PRKCH0.49783406
128CDK30.49241698
129TAOK10.48937735
130WNK30.48067806
131MAPK100.47990510
132EPHA30.46695671
133CAMK1G0.45523916
134CDK70.43640460
135LMTK20.43213543
136CSNK1A10.42649013
137CDK20.41455315
138RAF10.40892172
139CSNK2A20.40198019
140RPS6KB10.40052588
141EIF2AK20.39750945
142CSNK2A10.39684760
143AKT20.38860904
144MARK20.38857583
145PRKCZ0.38677876
146CAMK10.38609173
147GSK3B0.38038664
148ALK0.37769252
149SCYL20.37440294
150MAPK80.37242456
151NEK60.36060669
152ROCK20.35113178
153HIPK20.35045830
154PRKCB0.34755236
155CAMK2D0.34503730
156MAPK90.33829037

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.65381928
2Synaptic vesicle cycle_Homo sapiens_hsa047213.32335925
3GABAergic synapse_Homo sapiens_hsa047272.80481514
4Olfactory transduction_Homo sapiens_hsa047402.79483186
5Proteasome_Homo sapiens_hsa030502.73323768
6Circadian entrainment_Homo sapiens_hsa047132.70046183
7Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.66009741
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.63702759
9Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.56997746
10Steroid biosynthesis_Homo sapiens_hsa001002.50322525
11Mismatch repair_Homo sapiens_hsa034302.49277351
12Glutamatergic synapse_Homo sapiens_hsa047242.49177433
13Morphine addiction_Homo sapiens_hsa050322.46988938
14DNA replication_Homo sapiens_hsa030302.33470802
15Dopaminergic synapse_Homo sapiens_hsa047282.31935649
16Long-term potentiation_Homo sapiens_hsa047202.29752210
17Base excision repair_Homo sapiens_hsa034102.27633542
18Amphetamine addiction_Homo sapiens_hsa050312.18309733
19Insulin secretion_Homo sapiens_hsa049112.03760222
20Fanconi anemia pathway_Homo sapiens_hsa034602.02235395
21RNA transport_Homo sapiens_hsa030131.97606787
22Phototransduction_Homo sapiens_hsa047441.97130774
23Cholinergic synapse_Homo sapiens_hsa047251.93382314
24Basal transcription factors_Homo sapiens_hsa030221.89549524
25Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.89488962
26Cell cycle_Homo sapiens_hsa041101.89066223
27Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.88245716
28Oxidative phosphorylation_Homo sapiens_hsa001901.81865686
29Cocaine addiction_Homo sapiens_hsa050301.79201076
30Fatty acid elongation_Homo sapiens_hsa000621.78702655
31Homologous recombination_Homo sapiens_hsa034401.74929772
322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.73620780
33Serotonergic synapse_Homo sapiens_hsa047261.73031513
34Non-homologous end-joining_Homo sapiens_hsa034501.72971869
35Propanoate metabolism_Homo sapiens_hsa006401.71404401
36Parkinsons disease_Homo sapiens_hsa050121.70166267
37Taste transduction_Homo sapiens_hsa047421.65821906
38Aldosterone synthesis and secretion_Homo sapiens_hsa049251.64012093
39Long-term depression_Homo sapiens_hsa047301.63921527
40Salivary secretion_Homo sapiens_hsa049701.60911560
41Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.58449716
42Pyruvate metabolism_Homo sapiens_hsa006201.57505999
43Oocyte meiosis_Homo sapiens_hsa041141.55494584
44Selenocompound metabolism_Homo sapiens_hsa004501.52879627
45Spliceosome_Homo sapiens_hsa030401.52220365
46Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.50967724
47Oxytocin signaling pathway_Homo sapiens_hsa049211.49886660
48Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.48266336
49Gastric acid secretion_Homo sapiens_hsa049711.47250003
50Renin secretion_Homo sapiens_hsa049241.46616439
51Protein export_Homo sapiens_hsa030601.45329254
52Nucleotide excision repair_Homo sapiens_hsa034201.42329995
53Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.41066600
54Carbon metabolism_Homo sapiens_hsa012001.37665632
55Gap junction_Homo sapiens_hsa045401.36616593
56Axon guidance_Homo sapiens_hsa043601.35231400
57Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.34651379
58RNA degradation_Homo sapiens_hsa030181.33138445
59Biosynthesis of amino acids_Homo sapiens_hsa012301.32340578
60Huntingtons disease_Homo sapiens_hsa050161.31546557
61Cysteine and methionine metabolism_Homo sapiens_hsa002701.28054205
62GnRH signaling pathway_Homo sapiens_hsa049121.27902864
63Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.24139163
64Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.22539490
65Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.22236153
66Calcium signaling pathway_Homo sapiens_hsa040201.22127049
67Type II diabetes mellitus_Homo sapiens_hsa049301.21933511
68Circadian rhythm_Homo sapiens_hsa047101.21264425
69Glioma_Homo sapiens_hsa052141.20322663
70Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.19529813
71Estrogen signaling pathway_Homo sapiens_hsa049151.19456776
72Fatty acid metabolism_Homo sapiens_hsa012121.19175151
73cAMP signaling pathway_Homo sapiens_hsa040241.18280801
74ErbB signaling pathway_Homo sapiens_hsa040121.16399767
75Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.15650564
76Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.14785001
77Butanoate metabolism_Homo sapiens_hsa006501.13550589
78Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.10425423
79Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.06857799
80RNA polymerase_Homo sapiens_hsa030201.06183244
81Dorso-ventral axis formation_Homo sapiens_hsa043201.03950885
82Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.02988660
83N-Glycan biosynthesis_Homo sapiens_hsa005101.02305848
84Phosphatidylinositol signaling system_Homo sapiens_hsa040701.00792122
85Collecting duct acid secretion_Homo sapiens_hsa049661.00485896
86Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.00041661
87Alcoholism_Homo sapiens_hsa050340.97555317
88Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.93698659
89cGMP-PKG signaling pathway_Homo sapiens_hsa040220.93545186
90Pyrimidine metabolism_Homo sapiens_hsa002400.93011950
91Melanogenesis_Homo sapiens_hsa049160.92667050
92Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.88986856
93Vitamin B6 metabolism_Homo sapiens_hsa007500.87925743
94Phospholipase D signaling pathway_Homo sapiens_hsa040720.84373829
95Alzheimers disease_Homo sapiens_hsa050100.83771181
96beta-Alanine metabolism_Homo sapiens_hsa004100.83488431
97Peroxisome_Homo sapiens_hsa041460.83256117
98Neurotrophin signaling pathway_Homo sapiens_hsa047220.82315658
99Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.80053612
100Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.78478245
101Endometrial cancer_Homo sapiens_hsa052130.77627126
102mTOR signaling pathway_Homo sapiens_hsa041500.77150323
103MAPK signaling pathway_Homo sapiens_hsa040100.75796968
104Vibrio cholerae infection_Homo sapiens_hsa051100.74557356
105Colorectal cancer_Homo sapiens_hsa052100.74194873
106Thyroid hormone signaling pathway_Homo sapiens_hsa049190.73932224
107Purine metabolism_Homo sapiens_hsa002300.73375052
108Choline metabolism in cancer_Homo sapiens_hsa052310.70202813
109Carbohydrate digestion and absorption_Homo sapiens_hsa049730.69116204
110Glucagon signaling pathway_Homo sapiens_hsa049220.68589139
111Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.65732634
112Renal cell carcinoma_Homo sapiens_hsa052110.65194355
113Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.62440528
114Ras signaling pathway_Homo sapiens_hsa040140.62341987
115Wnt signaling pathway_Homo sapiens_hsa043100.62097243
116Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.61756360
117Vascular smooth muscle contraction_Homo sapiens_hsa042700.61654282
118Metabolic pathways_Homo sapiens_hsa011000.60864010
119Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.60313609
120Insulin signaling pathway_Homo sapiens_hsa049100.59150319
121Cardiac muscle contraction_Homo sapiens_hsa042600.57923940
122Regulation of autophagy_Homo sapiens_hsa041400.57704267
123Thyroid hormone synthesis_Homo sapiens_hsa049180.57499712
124Non-small cell lung cancer_Homo sapiens_hsa052230.56545055
125Fatty acid biosynthesis_Homo sapiens_hsa000610.55056770
126mRNA surveillance pathway_Homo sapiens_hsa030150.54848795
127Arginine and proline metabolism_Homo sapiens_hsa003300.54215955
128Longevity regulating pathway - mammal_Homo sapiens_hsa042110.54004124
129Folate biosynthesis_Homo sapiens_hsa007900.53246447
130Central carbon metabolism in cancer_Homo sapiens_hsa052300.53167259
131VEGF signaling pathway_Homo sapiens_hsa043700.52941388
132Endocytosis_Homo sapiens_hsa041440.52564980
133Lysine degradation_Homo sapiens_hsa003100.51790595
134Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.51288912
135SNARE interactions in vesicular transport_Homo sapiens_hsa041300.50171070
136Pancreatic secretion_Homo sapiens_hsa049720.49984575
137Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.49178146
138Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.49130142
139Tryptophan metabolism_Homo sapiens_hsa003800.47652210
140Type I diabetes mellitus_Homo sapiens_hsa049400.46593559
141Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.44601117
142Prolactin signaling pathway_Homo sapiens_hsa049170.43633481
143Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.43515658
144Sphingolipid signaling pathway_Homo sapiens_hsa040710.43502766
145p53 signaling pathway_Homo sapiens_hsa041150.41339451
146Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.40230439
147Tight junction_Homo sapiens_hsa045300.40135742
148Hippo signaling pathway_Homo sapiens_hsa043900.39714365
149Rap1 signaling pathway_Homo sapiens_hsa040150.36969105
150Inositol phosphate metabolism_Homo sapiens_hsa005620.36689774
151Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.36039336
152Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.35546275
153Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.35331002
154AMPK signaling pathway_Homo sapiens_hsa041520.35244777
155Ovarian steroidogenesis_Homo sapiens_hsa049130.34860705
156Arginine biosynthesis_Homo sapiens_hsa002200.34614219
157Dilated cardiomyopathy_Homo sapiens_hsa054140.33464998
158Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.32462777
159Thyroid cancer_Homo sapiens_hsa052160.32225597
160Hedgehog signaling pathway_Homo sapiens_hsa043400.31812815
161Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.29789171
162Fatty acid degradation_Homo sapiens_hsa000710.27203383
163Melanoma_Homo sapiens_hsa052180.27018268
164Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.25568321
165Cyanoamino acid metabolism_Homo sapiens_hsa004600.25012599
166Vitamin digestion and absorption_Homo sapiens_hsa049770.23373771

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