TEAD4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. It is preferentially expressed in the skeletal muscle, and binds to the M-CAT regulatory element found in promoters of muscle-specific genes to direct their gene expression. Alternatively spliced transcripts encoding distinct isoforms, some of which are translated through the use of a non-AUG (UUG) initiation codon, have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1purine nucleobase biosynthetic process (GO:0009113)5.74774844
2nucleobase biosynthetic process (GO:0046112)5.26608483
3ribosome assembly (GO:0042255)5.11735152
4mitotic metaphase plate congression (GO:0007080)5.00706110
5formation of translation preinitiation complex (GO:0001731)4.91010142
6folic acid metabolic process (GO:0046655)4.79210906
7ribosome biogenesis (GO:0042254)4.71776447
8mitotic chromosome condensation (GO:0007076)4.62791083
9DNA unwinding involved in DNA replication (GO:0006268)4.49493421
10intestinal epithelial cell development (GO:0060576)4.49219116
11regulation of spindle organization (GO:0090224)4.42037074
12vitamin transmembrane transport (GO:0035461)4.42007059
13regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.37330350
14DNA replication checkpoint (GO:0000076)4.28132199
15folic acid transport (GO:0015884)4.21779548
16lung-associated mesenchyme development (GO:0060484)4.18754598
17regulation of G0 to G1 transition (GO:0070316)4.16720972
18protein localization to kinetochore (GO:0034501)4.09574591
19protein complex localization (GO:0031503)4.00662586
20rRNA modification (GO:0000154)3.93427417
21regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.89418240
22regulation of translation in response to stress (GO:0043555)3.89023189
23positive regulation of chromosome segregation (GO:0051984)3.81124157
24labyrinthine layer development (GO:0060711)3.78753569
25metaphase plate congression (GO:0051310)3.74992649
26heterochromatin organization (GO:0070828)3.72489129
27transcription from mitochondrial promoter (GO:0006390)3.71623445
28muscle filament sliding (GO:0030049)3.69325830
29actin-myosin filament sliding (GO:0033275)3.69325830
30DNA strand elongation involved in DNA replication (GO:0006271)3.68211344
31nuclear pore complex assembly (GO:0051292)3.64463063
32regulation of mitotic spindle organization (GO:0060236)3.61864309
33ribonucleoprotein complex biogenesis (GO:0022613)3.61812978
34cellular protein complex localization (GO:0034629)3.61308265
35DNA strand elongation (GO:0022616)3.61239573
36interferon-gamma secretion (GO:0072643)3.57606704
37blastocyst development (GO:0001824)3.57473335
38establishment of integrated proviral latency (GO:0075713)3.56262688
39mitotic nuclear envelope disassembly (GO:0007077)3.55870897
40mitotic sister chromatid segregation (GO:0000070)3.53333813
41termination of RNA polymerase I transcription (GO:0006363)3.53111520
42transcription from RNA polymerase I promoter (GO:0006360)3.52634220
43trophectodermal cell differentiation (GO:0001829)3.49885510
44maturation of SSU-rRNA (GO:0030490)3.48826761
45proline biosynthetic process (GO:0006561)3.45389110
46regulation of translational fidelity (GO:0006450)3.41430114
47IMP metabolic process (GO:0046040)3.40765452
48transcription elongation from RNA polymerase III promoter (GO:0006385)3.40223198
49termination of RNA polymerase III transcription (GO:0006386)3.40223198
50protein localization to chromosome, centromeric region (GO:0071459)3.38820690
51paraxial mesoderm development (GO:0048339)3.32873121
52spindle checkpoint (GO:0031577)3.32778643
53membrane disassembly (GO:0030397)3.32664322
54nuclear envelope disassembly (GO:0051081)3.32664322
55transcription elongation from RNA polymerase I promoter (GO:0006362)3.32657052
56IMP biosynthetic process (GO:0006188)3.32072629
57rRNA processing (GO:0006364)3.30713519
58negative regulation of chromosome segregation (GO:0051985)3.25289078
59negative regulation of translational initiation (GO:0045947)3.25250206
60telomere maintenance via semi-conservative replication (GO:0032201)3.25023999
61anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.24929468
62mitotic spindle checkpoint (GO:0071174)3.24007877
63regulation of nuclear cell cycle DNA replication (GO:0033262)3.23998852
64proteasome assembly (GO:0043248)3.23778387
65L-serine metabolic process (GO:0006563)3.23736591
66rRNA metabolic process (GO:0016072)3.20971540
67regulation of chromosome segregation (GO:0051983)3.20463606
68histone arginine methylation (GO:0034969)3.20017614
69negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.18597441
70nuclear pore organization (GO:0006999)3.16466597
71DNA replication initiation (GO:0006270)3.15857464
72rRNA methylation (GO:0031167)3.15497912
73transcription initiation from RNA polymerase I promoter (GO:0006361)3.14600984
74modified amino acid transport (GO:0072337)3.14098047
75GMP metabolic process (GO:0046037)3.13836180
76actin-mediated cell contraction (GO:0070252)3.13769347
77protein K6-linked ubiquitination (GO:0085020)3.11330312
78spliceosomal snRNP assembly (GO:0000387)3.11008033
79mitotic spindle assembly checkpoint (GO:0007094)3.10172077
80DNA replication-dependent nucleosome organization (GO:0034723)3.09318901
81DNA replication-dependent nucleosome assembly (GO:0006335)3.09318901
82regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.08561992
83peptidyl-arginine omega-N-methylation (GO:0035247)3.07786038
84negative regulation of mitotic sister chromatid separation (GO:2000816)3.07099756
85negative regulation of mitotic sister chromatid segregation (GO:0033048)3.07099756
86negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.07099756
87negative regulation of sister chromatid segregation (GO:0033046)3.07099756
88nuclear envelope organization (GO:0006998)3.05684250
89spindle assembly checkpoint (GO:0071173)3.05594660
90mitotic G1 DNA damage checkpoint (GO:0031571)3.05060544
91positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.01696899
92regulation of mitotic metaphase/anaphase transition (GO:0030071)3.01398371
93DNA deamination (GO:0045006)3.01340116
94maturation of 5.8S rRNA (GO:0000460)2.99737809
95autophagic vacuole assembly (GO:0000045)2.98962841
96regulation of mammary gland epithelial cell proliferation (GO:0033599)2.98044244
97regulation of double-strand break repair via homologous recombination (GO:0010569)2.97903978
98negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.96713965
99histone-serine phosphorylation (GO:0035404)2.96522871
100ribosomal small subunit biogenesis (GO:0042274)2.94680653
101establishment of protein localization to mitochondrial membrane (GO:0090151)2.93721918
102regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.93502563
103regulation of posttranscriptional gene silencing (GO:0060147)2.92775914
104regulation of gene silencing by miRNA (GO:0060964)2.92775914
105regulation of gene silencing by RNA (GO:0060966)2.92775914
106establishment of chromosome localization (GO:0051303)2.92077562
107negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.91928310
108protein maturation by protein folding (GO:0022417)2.90867649
109pseudouridine synthesis (GO:0001522)2.88628679
1107-methylguanosine mRNA capping (GO:0006370)2.86861420
111positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.86598153
112regulation of telomere maintenance via telomerase (GO:0032210)2.86226549
113sister chromatid segregation (GO:0000819)2.85837861
114ribosomal large subunit biogenesis (GO:0042273)2.84619043
115regulation of centrosome cycle (GO:0046605)2.80634268
116adherens junction assembly (GO:0034333)2.79655113
117regulation of sister chromatid segregation (GO:0033045)2.79038512
118regulation of mitotic sister chromatid separation (GO:0010965)2.79038512
119regulation of mitotic sister chromatid segregation (GO:0033047)2.79038512
120anterior/posterior axis specification, embryo (GO:0008595)2.78926472
121muscle cell fate commitment (GO:0042693)2.77134230
122regulation of translational termination (GO:0006449)2.76647138
123regulation of hippo signaling (GO:0035330)2.76230597
124notochord development (GO:0030903)2.76162935
125cell-substrate adherens junction assembly (GO:0007045)2.76038898
126focal adhesion assembly (GO:0048041)2.76038898
127chromosome condensation (GO:0030261)2.74990992
128G1 DNA damage checkpoint (GO:0044783)2.74671308
129histone H2A monoubiquitination (GO:0035518)2.74601112
130attachment of spindle microtubules to kinetochore (GO:0008608)2.74244589
131nucleobase-containing small molecule interconversion (GO:0015949)2.73912734
132skeletal muscle contraction (GO:0003009)2.70793876
133COPI coating of Golgi vesicle (GO:0048205)2.68959404
134Golgi transport vesicle coating (GO:0048200)2.68959404
135ventricular cardiac muscle cell development (GO:0055015)2.65874272
136positive regulation of SMAD protein import into nucleus (GO:0060391)2.65610004
137mitotic sister chromatid cohesion (GO:0007064)2.64305073
138establishment of viral latency (GO:0019043)2.62609968
139rRNA transcription (GO:0009303)2.60865182
140telomere maintenance via recombination (GO:0000722)2.59303946
141response to muscle activity (GO:0014850)2.57413658
142regulation of mitochondrial translation (GO:0070129)2.56556394
143mitochondrial fusion (GO:0008053)2.53656359
144peptidyl-arginine N-methylation (GO:0035246)2.50405287
145peptidyl-arginine methylation (GO:0018216)2.50405287
146folic acid-containing compound biosynthetic process (GO:0009396)2.50147793
147NADH metabolic process (GO:0006734)2.49710709
148ncRNA 3-end processing (GO:0043628)2.49378029
149planar cell polarity pathway involved in neural tube closure (GO:0090179)2.49178406
150pore complex assembly (GO:0046931)2.48636187
151mitotic recombination (GO:0006312)2.47817256
152regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.45771164
153apoptotic process involved in morphogenesis (GO:0060561)2.45680164
154negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.43880662
1554-hydroxyproline metabolic process (GO:0019471)2.42965495
156mitochondrial DNA metabolic process (GO:0032042)2.42951919
157convergent extension (GO:0060026)2.40817487
158sarcomere organization (GO:0045214)2.40552550
159tRNA aminoacylation for protein translation (GO:0006418)2.40083869
160ribosomal small subunit assembly (GO:0000028)2.39266224
161proline metabolic process (GO:0006560)2.39264009
162epithelial cell-cell adhesion (GO:0090136)2.38470407
163DNA duplex unwinding (GO:0032508)2.36255432
164gluconeogenesis (GO:0006094)2.36213695
165spliceosomal tri-snRNP complex assembly (GO:0000244)2.35828954
166L-alpha-amino acid transmembrane transport (GO:1902475)2.33277050
167skeletal muscle fiber development (GO:0048741)2.32633066
168negative regulation of cell size (GO:0045792)2.28890783
169amino acid activation (GO:0043038)2.28749950
170tRNA aminoacylation (GO:0043039)2.28749950

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.86606212
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.81921177
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.56888597
4MYC_19079543_ChIP-ChIP_MESCs_Mouse3.09756817
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.02115015
6ETS1_20019798_ChIP-Seq_JURKAT_Human2.83259656
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.79610757
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.76922853
9CREB1_15753290_ChIP-ChIP_HEK293T_Human2.76522745
10MYC_19030024_ChIP-ChIP_MESCs_Mouse2.64048736
11MYC_18358816_ChIP-ChIP_MESCs_Mouse2.59828731
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.55407562
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.48133881
14E2F4_17652178_ChIP-ChIP_JURKAT_Human2.46594410
15MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.42646094
16KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.39203224
17KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.39203224
18KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.39203224
19ZNF263_19887448_ChIP-Seq_K562_Human2.36674996
20AR_21909140_ChIP-Seq_LNCAP_Human2.33363179
21POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.33093863
22GABP_17652178_ChIP-ChIP_JURKAT_Human2.31815507
23EST1_17652178_ChIP-ChIP_JURKAT_Human2.31026087
24NANOG_18555785_ChIP-Seq_MESCs_Mouse2.25932361
25SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.22947695
26NELFA_20434984_ChIP-Seq_ESCs_Mouse2.13301110
27NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.07666143
28NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.06034357
29POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.98147607
30STAT3_1855785_ChIP-Seq_MESCs_Mouse1.96784328
31XRN2_22483619_ChIP-Seq_HELA_Human1.90626664
32CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.88996634
33KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.85754097
34MYCN_18555785_ChIP-Seq_MESCs_Mouse1.83386809
35TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.81240949
36* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.81059698
37GABP_19822575_ChIP-Seq_HepG2_Human1.76631291
38RARG_19884340_ChIP-ChIP_MEFs_Mouse1.76265922
39KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.74139970
40VDR_23849224_ChIP-Seq_CD4+_Human1.73806291
41TCF3_18692474_ChIP-Seq_MEFs_Mouse1.70153948
42NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.69566567
43DCP1A_22483619_ChIP-Seq_HELA_Human1.67685275
44KLF4_18555785_ChIP-Seq_MESCs_Mouse1.66837808
45TP63_17297297_ChIP-ChIP_HaCaT_Human1.66335413
46MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.63085872
47YY1_21170310_ChIP-Seq_MESCs_Mouse1.62266646
48TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55806334
49CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.54717431
50NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.53425115
51TP63_19390658_ChIP-ChIP_HaCaT_Human1.50997026
52KDM5A_27292631_Chip-Seq_BREAST_Human1.50011597
53SALL1_21062744_ChIP-ChIP_HESCs_Human1.48593849
54PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.48561682
55NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.45938631
56SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.44632767
57* RACK7_27058665_Chip-Seq_MCF-7_Human1.42383979
58TCF3_18692474_ChIP-Seq_MESCs_Mouse1.40904101
59EGR1_19374776_ChIP-ChIP_THP-1_Human1.39887878
60POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.38293131
61DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.37860004
62SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.37772882
63TTF2_22483619_ChIP-Seq_HELA_Human1.37377163
64CLOCK_20551151_ChIP-Seq_293T_Human1.34957566
65E2F1_21310950_ChIP-Seq_MCF-7_Human1.33938624
66FOXP3_21729870_ChIP-Seq_TREG_Human1.33932484
67* ELK3_25401928_ChIP-Seq_HUVEC_Human1.32517086
68NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.32378046
69THAP11_20581084_ChIP-Seq_MESCs_Mouse1.29902503
70* NANOG_21062744_ChIP-ChIP_HESCs_Human1.28697189
71KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.27687189
72* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.25719813
73* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.25322659
74* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.24665919
75HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.24618707
76ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.24548941
77SOX2_18692474_ChIP-Seq_MEFs_Mouse1.24189048
78ELK1_22589737_ChIP-Seq_MCF10A_Human1.22724859
79* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.22617569
80SOX2_18555785_ChIP-Seq_MESCs_Mouse1.21391906
81* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.19686613
82PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19506187
83TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.17723267
84ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.17313651
85ESR1_15608294_ChIP-ChIP_MCF-7_Human1.17013473
86* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.17000524
87KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.16617761
88ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.16529815
89TET1_21451524_ChIP-Seq_MESCs_Mouse1.16277943
90YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.16248147
91ZFP281_18757296_ChIP-ChIP_E14_Mouse1.15010240
92ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.14120565
93* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.13923603
94NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.13917170
95LXR_22292898_ChIP-Seq_THP-1_Human1.13444525
96ATF3_27146783_Chip-Seq_COLON_Human1.12637652
97SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.11470892
98CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.10974599
99ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.10239172
100HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.10130651
101TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09939730
102NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.09874452
103RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.09599748
104SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.07642594
105SOX2_18692474_ChIP-Seq_MESCs_Mouse1.05455225
106* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.05353728
107ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.04499445
108TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.04301108
109SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.04181817
110* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.01869871
111PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.01863521
112MYC_22102868_ChIP-Seq_BL_Human1.01003832
113BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.99862892
114* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.99774632
115* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.99740114
116TBX5_21415370_ChIP-Seq_HL-1_Mouse0.99528598
117DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.98871461
118TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.98578016
119* KAP1_27257070_Chip-Seq_ESCs_Mouse0.98196197
120TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.97693079
121UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.97480632
122E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.97434640
123TFEB_21752829_ChIP-Seq_HELA_Human0.97159411
124SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.97100956
125CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.94633269
126ELK1_19687146_ChIP-ChIP_HELA_Human0.94070777
127CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.92709308
128CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.91936741
129POU5F1_16518401_ChIP-PET_MESCs_Mouse0.89827264
130CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.88141863

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.08423400
2MP0003111_abnormal_nucleus_morphology4.20915815
3* MP0004957_abnormal_blastocyst_morpholog3.72610939
4MP0003718_maternal_effect3.07988976
5MP0000751_myopathy3.00995916
6MP0003077_abnormal_cell_cycle2.97300449
7MP0010094_abnormal_chromosome_stability2.83896274
8MP0000749_muscle_degeneration2.77740473
9MP0008057_abnormal_DNA_replication2.77263689
10MP0009840_abnormal_foam_cell2.41592842
11MP0001730_embryonic_growth_arrest2.38123822
12MP0003123_paternal_imprinting2.23465856
13MP0008932_abnormal_embryonic_tissue2.21115639
14* MP0001672_abnormal_embryogenesis/_devel2.14918355
15* MP0005380_embryogenesis_phenotype2.14918355
16MP0008260_abnormal_autophagy2.08472181
17MP0003786_premature_aging2.08345666
18MP0003984_embryonic_growth_retardation1.99693680
19MP0004087_abnormal_muscle_fiber1.97817629
20MP0002088_abnormal_embryonic_growth/wei1.96227409
21MP0000759_abnormal_skeletal_muscle1.92101840
22MP0000350_abnormal_cell_proliferation1.92072781
23MP0003646_muscle_fatigue1.91294247
24MP0008058_abnormal_DNA_repair1.86149150
25MP0000750_abnormal_muscle_regeneration1.85006101
26MP0010352_gastrointestinal_tract_polyps1.82703175
27MP0001697_abnormal_embryo_size1.81687869
28MP0003567_abnormal_fetal_cardiomyocyte1.81517656
29MP0003705_abnormal_hypodermis_morpholog1.81431895
30MP0003941_abnormal_skin_development1.80829186
31MP0004145_abnormal_muscle_electrophysio1.78194524
32MP0010030_abnormal_orbit_morphology1.76474857
33* MP0002086_abnormal_extraembryonic_tissu1.74596965
34MP0005377_hearing/vestibular/ear_phenot1.67748912
35MP0003878_abnormal_ear_physiology1.67748912
36MP0002085_abnormal_embryonic_tissue1.66609735
37MP0002084_abnormal_developmental_patter1.64970645
38MP0002106_abnormal_muscle_physiology1.60493949
39* MP0002080_prenatal_lethality1.59668895
40MP0001542_abnormal_bone_strength1.56425870
41MP0008007_abnormal_cellular_replicative1.56409947
42MP0004264_abnormal_extraembryonic_tissu1.53032174
43MP0004197_abnormal_fetal_growth/weight/1.51352316
44MP0004036_abnormal_muscle_relaxation1.50758948
45MP0003119_abnormal_digestive_system1.49665085
46MP0008438_abnormal_cutaneous_collagen1.44960698
47MP0010368_abnormal_lymphatic_system1.44347201
48MP0010630_abnormal_cardiac_muscle1.44116334
49MP0002653_abnormal_ependyma_morphology1.44022561
50MP0005369_muscle_phenotype1.42205326
51MP0010307_abnormal_tumor_latency1.37834115
52MP0010234_abnormal_vibrissa_follicle1.35083502
53MP0000733_abnormal_muscle_development1.34595816
54MP0004858_abnormal_nervous_system1.31015021
55MP0004084_abnormal_cardiac_muscle1.31014671
56MP0005257_abnormal_intraocular_pressure1.28370695
57MP0002877_abnormal_melanocyte_morpholog1.27150824
58MP0003566_abnormal_cell_adhesion1.22193974
59MP0000003_abnormal_adipose_tissue1.21278568
60MP0002108_abnormal_muscle_morphology1.20053331
61MP0005395_other_phenotype1.19932959
62MP0000678_abnormal_parathyroid_gland1.18706596
63MP0003221_abnormal_cardiomyocyte_apopto1.18367502
64MP0002697_abnormal_eye_size1.17093344
65MP0002796_impaired_skin_barrier1.15961017
66MP0005076_abnormal_cell_differentiation1.13753725
67MP0003315_abnormal_perineum_morphology1.13183212
68MP0002254_reproductive_system_inflammat1.12976739
69MP0002269_muscular_atrophy1.11714988
70MP0003937_abnormal_limbs/digits/tail_de1.09156316
71MP0001346_abnormal_lacrimal_gland1.08758868
72MP0001849_ear_inflammation1.08698599
73MP0001293_anophthalmia1.07564324
74MP0000428_abnormal_craniofacial_morphol1.06123374
75MP0002089_abnormal_postnatal_growth/wei1.05680631
76MP0005623_abnormal_meninges_morphology1.04513162
77MP0003938_abnormal_ear_development1.04212281
78MP0002127_abnormal_cardiovascular_syste1.03031716
79MP0003828_pulmonary_edema1.01482052
80MP0002396_abnormal_hematopoietic_system1.00846950
81MP0009278_abnormal_bone_marrow1.00805753
82MP0005501_abnormal_skin_physiology0.99109908
83MP0000747_muscle_weakness0.98829747
84MP0005451_abnormal_body_composition0.97842280
85MP0003890_abnormal_embryonic-extraembry0.97210681
86MP0004272_abnormal_basement_membrane0.95789563
87MP0000013_abnormal_adipose_tissue0.95436804
88MP0000313_abnormal_cell_death0.94333494
89MP0000762_abnormal_tongue_morphology0.93241150
90MP0003806_abnormal_nucleotide_metabolis0.92782140
91MP0002111_abnormal_tail_morphology0.92665128
92MP0003950_abnormal_plasma_membrane0.92660602
93MP0001661_extended_life_span0.92647904
94MP0003942_abnormal_urinary_system0.91721400
95MP0000358_abnormal_cell_content/0.91506670
96MP0005620_abnormal_muscle_contractility0.91171968
97MP0005023_abnormal_wound_healing0.90666714
98MP0003755_abnormal_palate_morphology0.89651481
99MP0003385_abnormal_body_wall0.89467422
100MP0001545_abnormal_hematopoietic_system0.87552438
101MP0005397_hematopoietic_system_phenotyp0.87552438
102MP0002249_abnormal_larynx_morphology0.87000271
103MP0005670_abnormal_white_adipose0.86551066
104MP0005621_abnormal_cell_physiology0.86287215
105MP0002163_abnormal_gland_morphology0.85350943
106MP0006035_abnormal_mitochondrial_morpho0.85001569
107MP0005375_adipose_tissue_phenotype0.84945790
108MP0000383_abnormal_hair_follicle0.84428924
109MP0002092_abnormal_eye_morphology0.84032068
110MP0000490_abnormal_crypts_of0.83882237
111MP0002972_abnormal_cardiac_muscle0.82871650
112MP0000579_abnormal_nail_morphology0.82683198
113MP0009672_abnormal_birth_weight0.82515243
114MP0000566_synostosis0.82191656
115MP0002132_abnormal_respiratory_system0.81688219
116MP0000432_abnormal_head_morphology0.81057294
117MP0005330_cardiomyopathy0.80476195
118MP0001145_abnormal_male_reproductive0.80284807
119MP0002060_abnormal_skin_morphology0.80074994
120MP0009703_decreased_birth_body0.80056155
121MP0000647_abnormal_sebaceous_gland0.79943970
122MP0000049_abnormal_middle_ear0.79922441
123MP0005384_cellular_phenotype0.79508835
124MP0009053_abnormal_anal_canal0.79470314
125MP0000627_abnormal_mammary_gland0.79074476
126MP0003935_abnormal_craniofacial_develop0.78481279
127MP0001299_abnormal_eye_distance/0.77979629
128MP0000467_abnormal_esophagus_morphology0.77676653
129MP0005508_abnormal_skeleton_morphology0.77242614
130MP0005666_abnormal_adipose_tissue0.77129495
131MP0002210_abnormal_sex_determination0.76021582
132MP0001348_abnormal_lacrimal_gland0.75549798
133MP0002019_abnormal_tumor_incidence0.74936191
134MP0009333_abnormal_splenocyte_physiolog0.74791474
135MP0006138_congestive_heart_failure0.73439119
136MP0002009_preneoplasia0.72516289
137MP0000537_abnormal_urethra_morphology0.72504193
138MP0004233_abnormal_muscle_weight0.70243067
139MP0004185_abnormal_adipocyte_glucose0.67684750
140MP0010678_abnormal_skin_adnexa0.67256836
141MP0000377_abnormal_hair_follicle0.65304243

Predicted human phenotypes

RankGene SetZ-score
1Breast hypoplasia (HP:0003187)4.90465419
2Type 1 muscle fiber predominance (HP:0003803)4.30499835
3Birth length less than 3rd percentile (HP:0003561)4.05803700
4Exercise-induced myalgia (HP:0003738)3.77724399
5Impulsivity (HP:0100710)3.71065844
6Carpal bone hypoplasia (HP:0001498)3.68190445
7Muscle fiber splitting (HP:0003555)3.63986407
8Round ear (HP:0100830)3.52744181
9Distal arthrogryposis (HP:0005684)3.52551193
10Abnormality of the umbilical cord (HP:0010881)3.49207092
11Rough bone trabeculation (HP:0100670)3.48336668
12Premature rupture of membranes (HP:0001788)3.46501196
13Exercise-induced muscle cramps (HP:0003710)3.42728660
14Difficulty climbing stairs (HP:0003551)3.42632159
15Cerebral hypomyelination (HP:0006808)3.40347580
16Trismus (HP:0000211)3.40204565
17Multiple enchondromatosis (HP:0005701)3.27056084
18Patellar aplasia (HP:0006443)3.26141374
19Aplasia/Hypoplasia of the patella (HP:0006498)3.24735597
20Ureteral duplication (HP:0000073)3.18794862
21Centrally nucleated skeletal muscle fibers (HP:0003687)3.18574957
22Aplasia/Hypoplasia involving the musculature (HP:0001460)3.16557885
23Hyperglycinemia (HP:0002154)3.15705825
24Aplasia of the musculature (HP:0100854)3.09276171
25Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.02952146
26Progressive muscle weakness (HP:0003323)3.01474338
27Absent radius (HP:0003974)3.00105133
28Ulnar deviation of the wrist (HP:0003049)2.97915129
29Aplasia/hypoplasia of the humerus (HP:0006507)2.94557146
30Distal lower limb muscle weakness (HP:0009053)2.88374429
31Hyperglycinuria (HP:0003108)2.83685266
32Absent forearm bone (HP:0003953)2.80119623
33Aplasia involving forearm bones (HP:0009822)2.80119623
34Abnormality of the distal phalanges of the toes (HP:0010182)2.77551320
35Premature ovarian failure (HP:0008209)2.76767413
36Popliteal pterygium (HP:0009756)2.71839069
37Entropion (HP:0000621)2.69244278
38Areflexia of lower limbs (HP:0002522)2.69192093
39Short humerus (HP:0005792)2.64091785
40Malignant hyperthermia (HP:0002047)2.63616974
41EMG: myopathic abnormalities (HP:0003458)2.62563518
42Neck muscle weakness (HP:0000467)2.60455594
43Short nail (HP:0001799)2.55195786
44Abnormalities of placenta or umbilical cord (HP:0001194)2.54038562
45Secondary amenorrhea (HP:0000869)2.53147004
46Spinal rigidity (HP:0003306)2.52526009
47Abnormality of skeletal muscle fiber size (HP:0012084)2.52355683
48Selective tooth agenesis (HP:0001592)2.51082545
49Abnormal trabecular bone morphology (HP:0100671)2.50996783
50Distal lower limb amyotrophy (HP:0008944)2.48804053
51Gout (HP:0001997)2.46270057
52Abnormality of the labia minora (HP:0012880)2.43493752
53Ileus (HP:0002595)2.42636091
54Male infertility (HP:0003251)2.39506095
55Alopecia of scalp (HP:0002293)2.38659483
56Spinal muscular atrophy (HP:0007269)2.37658451
57Pelvic girdle muscle weakness (HP:0003749)2.34825416
58Muscle fibrillation (HP:0010546)2.34721683
59Protrusio acetabuli (HP:0003179)2.32160247
60Fused cervical vertebrae (HP:0002949)2.30590586
61Myopathic facies (HP:0002058)2.30581400
62Calcaneovalgus deformity (HP:0001848)2.29909147
63Thin ribs (HP:0000883)2.29370651
64Sparse eyelashes (HP:0000653)2.29349187
65Irregular epiphyses (HP:0010582)2.29331610
66Rhabdomyolysis (HP:0003201)2.27552363
67Deformed tarsal bones (HP:0008119)2.27324472
68Pterygium (HP:0001059)2.26933523
69Ragged-red muscle fibers (HP:0003200)2.26299205
70Increased connective tissue (HP:0009025)2.25945473
71Achilles tendon contracture (HP:0001771)2.25711103
72Sparse lateral eyebrow (HP:0005338)2.25225554
73Generalized amyotrophy (HP:0003700)2.23983345
74Ankle contracture (HP:0006466)2.23649037
75Stillbirth (HP:0003826)2.22747279
76Muscle hypertrophy of the lower extremities (HP:0008968)2.22564309
77Atrioventricular block (HP:0001678)2.21442822
78Concave nail (HP:0001598)2.21051673
79Mildly elevated creatine phosphokinase (HP:0008180)2.21034097
80Abnormality of the anterior horn cell (HP:0006802)2.19719638
81Degeneration of anterior horn cells (HP:0002398)2.19719638
82Amniotic constriction ring (HP:0009775)2.19715431
83Abnormality of placental membranes (HP:0011409)2.19715431
84Pustule (HP:0200039)2.16467062
85Increased variability in muscle fiber diameter (HP:0003557)2.15400276
86Abnormality of glycine metabolism (HP:0010895)2.15382240
87Abnormality of serine family amino acid metabolism (HP:0010894)2.15382240
88Congenital, generalized hypertrichosis (HP:0004540)2.14096857
89Abnormality of the calcaneus (HP:0008364)2.13825190
90Muscle stiffness (HP:0003552)2.12319151
91Abnormality of the proximal phalanges of the hand (HP:0009834)2.10449421
92Chromosomal breakage induced by crosslinking agents (HP:0003221)2.10121052
93Rib fusion (HP:0000902)2.09672737
94Glossoptosis (HP:0000162)2.08676201
95Limb-girdle muscle atrophy (HP:0003797)2.08651019
96Ependymoma (HP:0002888)2.08522750
97Abnormality of the calf musculature (HP:0001430)2.07734048
98Shoulder girdle muscle weakness (HP:0003547)2.07177871
99Ulnar bowing (HP:0003031)2.07020809
100Rimmed vacuoles (HP:0003805)2.05405666
101Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.04011633
102Myoglobinuria (HP:0002913)2.03284368
103Hyporeflexia of lower limbs (HP:0002600)2.02755814
104Microretrognathia (HP:0000308)2.02588936
105Bulbar palsy (HP:0001283)2.02582334
106Breast aplasia (HP:0100783)2.02376248
107Shawl scrotum (HP:0000049)2.01859910
108Breech presentation (HP:0001623)2.01309606
109Absent phalangeal crease (HP:0006109)2.01170787
110Death in infancy (HP:0001522)2.00345516
111Aplasia/Hypoplasia of the sacrum (HP:0008517)1.99912463
112Abnormality of the Achilles tendon (HP:0005109)1.99062833
113Tongue fasciculations (HP:0001308)1.98052239
114Calf muscle hypertrophy (HP:0008981)1.97646427
115Nemaline bodies (HP:0003798)1.97634368
116Oral leukoplakia (HP:0002745)1.95373713
117Hyperacusis (HP:0010780)1.95070960
118Bundle branch block (HP:0011710)1.92400194
119Aplasia/Hypoplasia of the breasts (HP:0010311)1.91889973
120Abnormality of the hip-girdle musculature (HP:0001445)1.91294328
121Abnormality of the musculature of the pelvis (HP:0001469)1.91294328
122Muscle fiber inclusion bodies (HP:0100299)1.89147762
123Muscle fiber atrophy (HP:0100295)1.88825944
124Microvesicular hepatic steatosis (HP:0001414)1.88130281
125Patent foramen ovale (HP:0001655)1.87911027
126Tetraplegia (HP:0002445)1.85739884
127Osteolytic defects of the phalanges of the hand (HP:0009771)1.85426668
128Osteolytic defects of the hand bones (HP:0009699)1.85426668
129Lower limb amyotrophy (HP:0007210)1.85164895
130Absent hand (HP:0004050)1.83525523
131Abnormal umbilical cord blood vessels (HP:0011403)1.83351151
132Single umbilical artery (HP:0001195)1.83351151
133Abnormality of the fetal cardiovascular system (HP:0010948)1.83351151
134Subaortic stenosis (HP:0001682)1.82648128
135Abnormality of the left ventricular outflow tract (HP:0011103)1.82648128
136CNS hypomyelination (HP:0003429)1.81200988
137Chromsome breakage (HP:0040012)1.80272481
138Hypoplasia of the capital femoral epiphysis (HP:0003090)1.79693749
139Meckel diverticulum (HP:0002245)1.77976642
140Progressive external ophthalmoplegia (HP:0000590)1.76552399
141Megaloblastic anemia (HP:0001889)1.76208807
142Type 2 muscle fiber atrophy (HP:0003554)1.76060125
143Personality changes (HP:0000751)1.75546967
144Flat capital femoral epiphysis (HP:0003370)1.74784582
145Natal tooth (HP:0000695)1.73804525
146Gowers sign (HP:0003391)1.73686265
147Polycythemia (HP:0001901)1.73275086
148Scapular winging (HP:0003691)1.72948430
149Fatigable weakness (HP:0003473)1.71715738
150Abnormality of the neuromuscular junction (HP:0003398)1.71715738
151Adducted thumb (HP:0001181)1.70586544
152Limb-girdle muscle weakness (HP:0003325)1.68647075
153Metatarsus adductus (HP:0001840)1.68576676
154Congenital hip dislocation (HP:0001374)1.63548185
155Shallow orbits (HP:0000586)1.61544093
156Increased nuchal translucency (HP:0010880)1.60420201
157Abnormality of glycolysis (HP:0004366)1.60097176
158Short palpebral fissure (HP:0012745)1.59892429
159Ventricular tachycardia (HP:0004756)1.59355966
160Deviation of the thumb (HP:0009603)1.58243613
161Abnormality of the tricuspid valve (HP:0001702)1.57826754
162Back pain (HP:0003418)1.56684665
163Generalized muscle weakness (HP:0003324)1.56225312
164Microglossia (HP:0000171)1.54336314
165Weak cry (HP:0001612)1.53234745
166Fetal akinesia sequence (HP:0001989)1.51759032
167Reticulocytopenia (HP:0001896)1.50614437
168Proximal placement of thumb (HP:0009623)1.50571091
169Renal duplication (HP:0000075)1.49002574
170Right ventricular cardiomyopathy (HP:0011663)1.47654549
171Abnormality of the shoulder girdle musculature (HP:0001435)1.47407361

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.56570469
2EPHA24.40083241
3WEE14.08286863
4AKT33.60304980
5SMG13.20706742
6NEK22.88290241
7OBSCN2.70539060
8PBK2.65738880
9PLK42.65455547
10EEF2K2.64866362
11NME22.26418065
12TTK2.26081301
13NEK12.23622314
14BRSK22.20634226
15LATS22.12665728
16VRK22.04261364
17EIF2AK11.96356465
18PLK11.93387004
19TSSK61.91073299
20DYRK31.76641543
21IRAK31.64535581
22PHKG21.63420097
23PHKG11.63420097
24PIM21.62934338
25SRPK11.59025981
26CDK121.54986059
27STK38L1.53624488
28MAP3K101.48594143
29CHEK21.44437163
30PLK31.43652290
31MKNK21.41749429
32CDK71.41032428
33DDR21.40073972
34STK31.38661404
35MST1R1.36965085
36MUSK1.34297111
37PDK21.34215867
38BRSK11.33906457
39AURKB1.32116347
40ACVR1B1.28547347
41PDK41.27374409
42PDK31.27374409
43AURKA1.21898161
44TRIB31.20213497
45ZAK1.19059265
46PINK11.17770550
47MAP3K31.17381958
48RPS6KB21.14791332
49RPS6KA41.14032711
50PAK41.11088132
51CDK81.10896082
52CDK41.10721220
53LATS11.08664106
54ALK1.08012627
55FGFR41.07089720
56MAP3K81.04795239
57LIMK11.04316517
58PRKCI1.04112740
59EIF2AK31.01936674
60MKNK11.01328031
61SIK11.01268580
62ERBB40.99775063
63STK100.96242731
64TAF10.95890753
65LMTK20.95765888
66STK160.95053729
67CDC70.94983919
68TESK10.93375162
69TESK20.90428579
70CHEK10.89544939
71PAK10.88839004
72ARAF0.86373049
73BRAF0.85495492
74MTOR0.84331635
75SCYL20.83991869
76PIM10.83802708
77TIE10.77592861
78AKT20.76254065
79PNCK0.75486849
80RIPK10.72108907
81CDK20.70423904
82MAP2K20.70318979
83DMPK0.69458001
84NME10.68688930
85STK40.68668775
86TYRO30.67939047
87ILK0.66945065
88KSR20.66068821
89PRKG20.65131002
90ICK0.62934839
91CDK190.62836394
92CDK60.61244333
93CCNB10.60620946
94MOS0.58239763
95KDR0.56261666
96CSNK1E0.55244466
97MAP3K110.52162870
98PRKD30.51482333
99NTRK10.49873644
100ATR0.49509565
101PRKAA10.47860150
102MELK0.47499258
103CDK90.47174782
104MAPK110.47103030
105PIK3CG0.46768726
106MARK30.46762085
107TAOK20.46510599
108PAK20.45790462
109MAPKAPK30.45108565
110TAOK10.43303186
111MAP2K30.43087317
112CDK10.42980618
113CSNK2A10.42971402
114STK380.40501560
115CSNK2A20.40142006
116PKN20.39652182
117GRK50.39153852
118DAPK10.38922495
119CAMK2G0.38790904
120FGFR10.38317628
121STK240.38208143
122ATM0.36667952
123DAPK30.36088003
124PTK20.35684458
125PDGFRA0.34939219
126CDK11A0.34556736
127CSNK1G10.34449042
128RPS6KA10.33078650
129GRK10.32650836
130BMX0.32189958
131MET0.32112814
132EIF2AK20.30396782
133TTN0.29172195
134MAP3K90.28063917
135MAP2K10.25836650
136MAP3K50.24216541
137TLK10.24128568
138CSNK1G30.23583833
139RAF10.22008890

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007506.21318232
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.60371346
3RNA polymerase_Homo sapiens_hsa030204.00967920
4RNA transport_Homo sapiens_hsa030133.52810658
5Proteasome_Homo sapiens_hsa030503.02411261
6Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.73155959
7Cell cycle_Homo sapiens_hsa041102.63572815
8DNA replication_Homo sapiens_hsa030302.59623063
9Spliceosome_Homo sapiens_hsa030402.40696473
10Mismatch repair_Homo sapiens_hsa034302.21887776
11Pyrimidine metabolism_Homo sapiens_hsa002402.09725111
12Regulation of autophagy_Homo sapiens_hsa041402.07443067
13Nucleotide excision repair_Homo sapiens_hsa034202.01953991
14Folate biosynthesis_Homo sapiens_hsa007902.01629696
15Base excision repair_Homo sapiens_hsa034102.01451497
16Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.99140471
17Ribosome_Homo sapiens_hsa030101.94622080
18p53 signaling pathway_Homo sapiens_hsa041151.90288865
19Basal transcription factors_Homo sapiens_hsa030221.82562328
20Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.81286104
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.71923130
22Homologous recombination_Homo sapiens_hsa034401.70165388
23mRNA surveillance pathway_Homo sapiens_hsa030151.52693374
24Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.44869415
25Fanconi anemia pathway_Homo sapiens_hsa034601.41091313
26Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.36535308
27Glycerophospholipid metabolism_Homo sapiens_hsa005641.36008078
28Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.35301646
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.33576991
30Fructose and mannose metabolism_Homo sapiens_hsa000511.31376973
31Pyruvate metabolism_Homo sapiens_hsa006201.30668346
32Oocyte meiosis_Homo sapiens_hsa041141.28381273
33Purine metabolism_Homo sapiens_hsa002301.27786499
34One carbon pool by folate_Homo sapiens_hsa006701.25735549
35Pentose phosphate pathway_Homo sapiens_hsa000301.21869093
36Vitamin digestion and absorption_Homo sapiens_hsa049771.21816235
37Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.17685865
38Cyanoamino acid metabolism_Homo sapiens_hsa004601.14229198
39Biosynthesis of amino acids_Homo sapiens_hsa012301.12597641
40Dilated cardiomyopathy_Homo sapiens_hsa054141.10894746
41Arginine biosynthesis_Homo sapiens_hsa002201.09722367
42Drug metabolism - other enzymes_Homo sapiens_hsa009831.08622873
43Sulfur relay system_Homo sapiens_hsa041221.08443904
44Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.08002635
45* Hippo signaling pathway_Homo sapiens_hsa043901.07580167
46Epstein-Barr virus infection_Homo sapiens_hsa051691.05065660
47RNA degradation_Homo sapiens_hsa030181.01395202
48Tight junction_Homo sapiens_hsa045300.98268559
49Cysteine and methionine metabolism_Homo sapiens_hsa002700.97990872
50mTOR signaling pathway_Homo sapiens_hsa041500.95044991
51Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.91295344
52Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.90980222
53Insulin signaling pathway_Homo sapiens_hsa049100.90232414
542-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.87761575
55Fatty acid elongation_Homo sapiens_hsa000620.85846364
56Hedgehog signaling pathway_Homo sapiens_hsa043400.83166793
57Glucagon signaling pathway_Homo sapiens_hsa049220.79913973
58Lysine degradation_Homo sapiens_hsa003100.78350420
59Small cell lung cancer_Homo sapiens_hsa052220.76674577
60N-Glycan biosynthesis_Homo sapiens_hsa005100.75851375
61Cardiac muscle contraction_Homo sapiens_hsa042600.70225126
62Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.69220557
63Adherens junction_Homo sapiens_hsa045200.66870012
64Arginine and proline metabolism_Homo sapiens_hsa003300.66794738
65Chronic myeloid leukemia_Homo sapiens_hsa052200.66547579
66Circadian rhythm_Homo sapiens_hsa047100.64935267
67Longevity regulating pathway - mammal_Homo sapiens_hsa042110.63879796
68MicroRNAs in cancer_Homo sapiens_hsa052060.63563848
69Steroid biosynthesis_Homo sapiens_hsa001000.62818771
70Selenocompound metabolism_Homo sapiens_hsa004500.60003306
71Galactose metabolism_Homo sapiens_hsa000520.58652442
72Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.58112261
73Bladder cancer_Homo sapiens_hsa052190.56255302
74Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.55061944
75Thyroid cancer_Homo sapiens_hsa052160.54284193
76Basal cell carcinoma_Homo sapiens_hsa052170.53792129
77Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.53076699
78Carbon metabolism_Homo sapiens_hsa012000.51333420
79Viral carcinogenesis_Homo sapiens_hsa052030.51086104
80Glutathione metabolism_Homo sapiens_hsa004800.49888502
81HTLV-I infection_Homo sapiens_hsa051660.48151976
82TGF-beta signaling pathway_Homo sapiens_hsa043500.47762910
83Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.47654948
84Arachidonic acid metabolism_Homo sapiens_hsa005900.46505513
85Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.46330931
86Phenylalanine metabolism_Homo sapiens_hsa003600.46058964
87Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.45793301
88ECM-receptor interaction_Homo sapiens_hsa045120.45107217
89Proteoglycans in cancer_Homo sapiens_hsa052050.41473444
90Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.41255986
91Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.40875130
92HIF-1 signaling pathway_Homo sapiens_hsa040660.40461317
93Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.39374116
94Renin-angiotensin system_Homo sapiens_hsa046140.38985266
95Huntingtons disease_Homo sapiens_hsa050160.38863422
96Fatty acid metabolism_Homo sapiens_hsa012120.38630153
97FoxO signaling pathway_Homo sapiens_hsa040680.38037391
98Endometrial cancer_Homo sapiens_hsa052130.37262295
99Melanoma_Homo sapiens_hsa052180.37184912
100AMPK signaling pathway_Homo sapiens_hsa041520.36392180
101Renal cell carcinoma_Homo sapiens_hsa052110.36306152
102Pancreatic cancer_Homo sapiens_hsa052120.35933465
103Linoleic acid metabolism_Homo sapiens_hsa005910.35529433
104Mineral absorption_Homo sapiens_hsa049780.35312224
105Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.32398201
106Colorectal cancer_Homo sapiens_hsa052100.32017995
107Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.31225510
108Focal adhesion_Homo sapiens_hsa045100.31037020
109Prostate cancer_Homo sapiens_hsa052150.30856898
110Non-homologous end-joining_Homo sapiens_hsa034500.29927888
111Metabolic pathways_Homo sapiens_hsa011000.29187307
112Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.28415859
113Pathways in cancer_Homo sapiens_hsa052000.28338989
114Thyroid hormone signaling pathway_Homo sapiens_hsa049190.28079103
115Regulation of actin cytoskeleton_Homo sapiens_hsa048100.27323388
116Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.27175100
117Notch signaling pathway_Homo sapiens_hsa043300.25767594
118Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.25555377
119PI3K-Akt signaling pathway_Homo sapiens_hsa041510.25409970
120Herpes simplex infection_Homo sapiens_hsa051680.24119116
121Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.24083254
122Central carbon metabolism in cancer_Homo sapiens_hsa052300.21094642
123Wnt signaling pathway_Homo sapiens_hsa043100.21054154
124Apoptosis_Homo sapiens_hsa042100.20335415
125Fatty acid biosynthesis_Homo sapiens_hsa000610.19321299
126Inositol phosphate metabolism_Homo sapiens_hsa005620.19287114
127Lysosome_Homo sapiens_hsa041420.18816591
128alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.18238450
129Antigen processing and presentation_Homo sapiens_hsa046120.17848892
130Endocytosis_Homo sapiens_hsa041440.17253696

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