TECR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a multi-pass membrane protein that resides in the endoplasmic reticulum, and belongs to the steroid 5-alpha reductase family. The elongation of microsomal long and very long chain fatty acid consists of 4 sequential reactions. This protein catalyzes the final step, reducing trans-2,3-enoyl-CoA to saturated acyl-CoA. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein maturation by protein folding (GO:0022417)4.82101752
2mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.78923551
3neuron cell-cell adhesion (GO:0007158)4.67310096
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.66516011
5synaptic vesicle exocytosis (GO:0016079)4.56178413
6deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.54484800
7proteasome assembly (GO:0043248)4.43305082
8regulation of mitochondrial translation (GO:0070129)4.40039331
9energy coupled proton transport, down electrochemical gradient (GO:0015985)4.35620279
10ATP synthesis coupled proton transport (GO:0015986)4.35620279
11chaperone-mediated protein transport (GO:0072321)4.32010794
12neuronal action potential propagation (GO:0019227)4.17750411
13presynaptic membrane assembly (GO:0097105)4.09269810
14respiratory electron transport chain (GO:0022904)4.02686029
15presynaptic membrane organization (GO:0097090)4.00870286
16oxidative phosphorylation (GO:0006119)3.98187740
17ATP hydrolysis coupled proton transport (GO:0015991)3.98141963
18energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.98141963
19electron transport chain (GO:0022900)3.93573442
20glutamate secretion (GO:0014047)3.87757708
21regulation of cellular amino acid metabolic process (GO:0006521)3.87359479
22vocalization behavior (GO:0071625)3.86034636
23GDP-mannose metabolic process (GO:0019673)3.82612028
24axon ensheathment in central nervous system (GO:0032291)3.82392870
25central nervous system myelination (GO:0022010)3.82392870
26respiratory chain complex IV assembly (GO:0008535)3.77445734
27negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.76236549
28cytochrome complex assembly (GO:0017004)3.73352747
29regulation of short-term neuronal synaptic plasticity (GO:0048172)3.71835722
30long-chain fatty acid biosynthetic process (GO:0042759)3.71583932
31regulation of synaptic vesicle exocytosis (GO:2000300)3.69163626
32negative regulation of synaptic transmission, GABAergic (GO:0032229)3.67135894
33regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.63827595
34transferrin transport (GO:0033572)3.57995962
35positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.54332579
36regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.53085582
37protein localization to synapse (GO:0035418)3.51160338
38mannosylation (GO:0097502)3.49161960
39negative regulation of ligase activity (GO:0051352)3.47693877
40negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.47693877
41DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.45597591
42regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.45490302
43erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.44949884
44L-phenylalanine metabolic process (GO:0006558)3.44949884
45neurotransmitter secretion (GO:0007269)3.44795293
46neurotransmitter uptake (GO:0001504)3.40034654
47metallo-sulfur cluster assembly (GO:0031163)3.37956092
48iron-sulfur cluster assembly (GO:0016226)3.37956092
49oxaloacetate metabolic process (GO:0006107)3.36902200
50neurotransmitter-gated ion channel clustering (GO:0072578)3.36575166
51neuron-neuron synaptic transmission (GO:0007270)3.34869401
52signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.34687237
53intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.34687237
54signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.33323539
55signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.33323539
56signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.33323539
57establishment of protein localization to mitochondrial membrane (GO:0090151)3.33161950
58protein deneddylation (GO:0000338)3.33008865
59trivalent inorganic cation transport (GO:0072512)3.32872846
60ferric iron transport (GO:0015682)3.32872846
61membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.30144042
62regulation of cholesterol esterification (GO:0010872)3.30050055
63regulation of glutamate receptor signaling pathway (GO:1900449)3.28532172
64anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.28324739
65gluconeogenesis (GO:0006094)3.26219215
66gamma-aminobutyric acid signaling pathway (GO:0007214)3.25990129
67cerebellar granule cell differentiation (GO:0021707)3.25855507
68regulation of synaptic vesicle transport (GO:1902803)3.22873815
69signal transduction involved in DNA integrity checkpoint (GO:0072401)3.22211462
70signal transduction involved in DNA damage checkpoint (GO:0072422)3.22211462
71synaptic vesicle maturation (GO:0016188)3.20486311
72postsynaptic membrane organization (GO:0001941)3.18890564
73purine nucleoside triphosphate biosynthetic process (GO:0009145)3.17977636
74synaptic transmission, glutamatergic (GO:0035249)3.16827560
75purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.15669239
76branched-chain amino acid catabolic process (GO:0009083)3.15557562
77protein complex biogenesis (GO:0070271)3.15404878
78signal transduction involved in cell cycle checkpoint (GO:0072395)3.13929058
79negative regulation of neurotransmitter transport (GO:0051589)3.13629005
80protein targeting to mitochondrion (GO:0006626)3.12970591
81positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.12915390
82proline biosynthetic process (GO:0006561)3.12358186
83monosaccharide biosynthetic process (GO:0046364)3.12161708
84synaptic vesicle docking involved in exocytosis (GO:0016081)3.11765087
85erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.11268172
86L-phenylalanine catabolic process (GO:0006559)3.11268172
87neuromuscular process controlling posture (GO:0050884)3.11023261
88positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.10471983
89positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.09683206
90lipopolysaccharide biosynthetic process (GO:0009103)3.09664752
91hexose biosynthetic process (GO:0019319)3.09512966
92regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.07930301
93aerobic respiration (GO:0009060)3.07382107
94positive regulation of synapse assembly (GO:0051965)3.06615981
95cellular ketone body metabolic process (GO:0046950)3.05050439
96neurotransmitter transport (GO:0006836)3.04369446
97ionotropic glutamate receptor signaling pathway (GO:0035235)3.04263493
98protein neddylation (GO:0045116)3.03876285
99gamma-aminobutyric acid transport (GO:0015812)3.03535813
100NADH metabolic process (GO:0006734)3.02731089
101regulation of cellular amine metabolic process (GO:0033238)3.02492685
102nuclear envelope reassembly (GO:0031468)3.01981594
103mitotic nuclear envelope reassembly (GO:0007084)3.01981594
104aldehyde catabolic process (GO:0046185)3.01414699
105mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.01382374
106mitochondrial respiratory chain complex I assembly (GO:0032981)3.01382374
107NADH dehydrogenase complex assembly (GO:0010257)3.01382374
108* fatty acid elongation (GO:0030497)3.00989123
109negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.99616933
110startle response (GO:0001964)2.98779779
111glutamate receptor signaling pathway (GO:0007215)2.95390113
112positive regulation of action potential (GO:0045760)2.95168777
113positive regulation of ligase activity (GO:0051351)2.94839427
114ketone body metabolic process (GO:1902224)2.94838261
115ribonucleoside triphosphate biosynthetic process (GO:0009201)2.93379435
116regulation of catecholamine metabolic process (GO:0042069)2.92786384
117regulation of dopamine metabolic process (GO:0042053)2.92786384
118regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.92541533
119regulation of cellular respiration (GO:0043457)2.91495554
120positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.90942666
121substantia nigra development (GO:0021762)2.89767298
122adult walking behavior (GO:0007628)2.89102250
123regulation of neurotransmitter levels (GO:0001505)2.87875066
124establishment of protein localization to mitochondrion (GO:0072655)2.87635892
125hydrogen ion transmembrane transport (GO:1902600)2.87072034
126transcription elongation from RNA polymerase III promoter (GO:0006385)2.86841989
127termination of RNA polymerase III transcription (GO:0006386)2.86841989
128glutathione derivative metabolic process (GO:1901685)2.86350702
129glutathione derivative biosynthetic process (GO:1901687)2.86350702
130tricarboxylic acid cycle (GO:0006099)2.85607147
131neuron recognition (GO:0008038)2.85178805
132positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.84706257
133negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.84632873
134transmission of nerve impulse (GO:0019226)2.84094974
135establishment of integrated proviral latency (GO:0075713)2.83360384
136dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.81047314
137long-term synaptic potentiation (GO:0060291)2.79818855
138mitochondrial respiratory chain complex assembly (GO:0033108)2.78738010
139purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.78708929
140purine nucleoside monophosphate biosynthetic process (GO:0009127)2.78708929
141establishment of viral latency (GO:0019043)2.76545439
142regulation of ubiquitin-protein transferase activity (GO:0051438)2.75877110
143mitochondrial transport (GO:0006839)2.75058016
144locomotory exploration behavior (GO:0035641)2.74748422
145heme biosynthetic process (GO:0006783)2.73883136
146telomere maintenance via semi-conservative replication (GO:0032201)2.73698877
147nucleoside triphosphate biosynthetic process (GO:0009142)2.73688410
148deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.72244488
149behavioral response to cocaine (GO:0048148)2.71786284
150mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.71426825
151succinate metabolic process (GO:0006105)2.71262625
152Golgi transport vesicle coating (GO:0048200)2.70760142
153COPI coating of Golgi vesicle (GO:0048205)2.70760142
154cullin deneddylation (GO:0010388)2.70759906
155protein localization to mitochondrion (GO:0070585)2.70610975
156ATP biosynthetic process (GO:0006754)2.69628922
157striatum development (GO:0021756)2.69395972
158pseudouridine synthesis (GO:0001522)2.69329099
159calcium-mediated signaling using intracellular calcium source (GO:0035584)2.68935950
1602-deoxyribonucleotide biosynthetic process (GO:0009265)2.68358310
161deoxyribose phosphate biosynthetic process (GO:0046385)2.68358310
162antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.66752057
163membrane hyperpolarization (GO:0060081)2.66740912
164cerebellar Purkinje cell differentiation (GO:0021702)2.66398608
165guanosine-containing compound biosynthetic process (GO:1901070)2.65650748
166proton transport (GO:0015992)2.63035942
167G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.62280262
168phagosome maturation (GO:0090382)2.62033834
169mechanosensory behavior (GO:0007638)2.60376955
170dopamine transport (GO:0015872)2.59460726
171hydrogen transport (GO:0006818)2.59404653
172regulation of voltage-gated calcium channel activity (GO:1901385)2.59122080
173regulation of glutamate secretion (GO:0014048)2.58602991
174regulation of synaptic transmission, glutamatergic (GO:0051966)2.58400524
175establishment of mitochondrion localization (GO:0051654)2.58210000
176regulation of vesicle fusion (GO:0031338)2.57830491
177inner mitochondrial membrane organization (GO:0007007)2.57674312
178regulation of protein kinase A signaling (GO:0010738)2.56963656
179regulation of neuronal synaptic plasticity (GO:0048168)2.55085285
180positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.54671721
181neuromuscular synaptic transmission (GO:0007274)2.54008382

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.78059696
2GBX2_23144817_ChIP-Seq_PC3_Human4.34567681
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.82296945
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.75979005
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.45998095
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.10667861
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.02709758
8TAF15_26573619_Chip-Seq_HEK293_Human2.96785591
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.90966122
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.87152597
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.80805856
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.74080939
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.69991354
14JARID2_20064375_ChIP-Seq_MESCs_Mouse2.68969135
15MYC_18555785_ChIP-Seq_MESCs_Mouse2.61306704
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.53596691
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.46528338
18SRF_21415370_ChIP-Seq_HL-1_Mouse2.45462331
19NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.42900578
20EZH2_27304074_Chip-Seq_ESCs_Mouse2.42347364
21TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.39025880
22SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.37297234
23JARID2_20075857_ChIP-Seq_MESCs_Mouse2.36699773
24REST_21632747_ChIP-Seq_MESCs_Mouse2.36033233
25SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.35997101
26SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.35736024
27TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.33274108
28EZH2_18974828_ChIP-Seq_MESCs_Mouse2.31324760
29RNF2_18974828_ChIP-Seq_MESCs_Mouse2.31324760
30EED_16625203_ChIP-ChIP_MESCs_Mouse2.30714215
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.29151799
32SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.19975424
33MTF2_20144788_ChIP-Seq_MESCs_Mouse2.19314157
34CTBP2_25329375_ChIP-Seq_LNCAP_Human2.17120284
35REST_18959480_ChIP-ChIP_MESCs_Mouse2.16593673
36E2F1_18555785_ChIP-Seq_MESCs_Mouse2.09573852
37CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.09335144
38ZFP57_27257070_Chip-Seq_ESCs_Mouse2.08169579
39XRN2_22483619_ChIP-Seq_HELA_Human2.05448115
40DCP1A_22483619_ChIP-Seq_HELA_Human2.04535347
41GABP_19822575_ChIP-Seq_HepG2_Human2.02861757
42CTBP1_25329375_ChIP-Seq_LNCAP_Human2.01752195
43CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.00609550
44MYC_19030024_ChIP-ChIP_MESCs_Mouse1.97356603
45SUZ12_27294783_Chip-Seq_ESCs_Mouse1.97225401
46EZH2_27294783_Chip-Seq_ESCs_Mouse1.95461465
47YY1_21170310_ChIP-Seq_MESCs_Mouse1.92859685
48BMI1_23680149_ChIP-Seq_NPCS_Mouse1.89697578
49CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.89017102
50CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.84722176
51ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.82995683
52ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.82124512
53E2F7_22180533_ChIP-Seq_HELA_Human1.78254058
54NELFA_20434984_ChIP-Seq_ESCs_Mouse1.77670582
55ELF1_17652178_ChIP-ChIP_JURKAT_Human1.77625991
56GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.77352963
57CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.74951578
58RARB_27405468_Chip-Seq_BRAIN_Mouse1.74832403
59MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.73916242
60SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.73782740
61ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.73417453
62RNF2_27304074_Chip-Seq_ESCs_Mouse1.69765789
63CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.69527940
64DROSHA_22980978_ChIP-Seq_HELA_Human1.69243452
65P300_19829295_ChIP-Seq_ESCs_Human1.65395605
66BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.64557341
67MYC_19079543_ChIP-ChIP_MESCs_Mouse1.63522919
68CBX2_27304074_Chip-Seq_ESCs_Mouse1.62649410
69PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.59947144
70FOXP3_21729870_ChIP-Seq_TREG_Human1.58775421
71SMAD4_21799915_ChIP-Seq_A2780_Human1.58601343
72POU3F2_20337985_ChIP-ChIP_501MEL_Human1.56116200
73AR_21572438_ChIP-Seq_LNCaP_Human1.55132165
74SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.54291361
75OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.53100413
76VDR_22108803_ChIP-Seq_LS180_Human1.52278138
77FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.51514151
78TET1_21451524_ChIP-Seq_MESCs_Mouse1.51492189
79TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49572293
80SRY_22984422_ChIP-ChIP_TESTIS_Rat1.48385349
81VDR_23849224_ChIP-Seq_CD4+_Human1.48183850
82NANOG_18555785_ChIP-Seq_MESCs_Mouse1.47798370
83NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.46357224
84PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.45520233
85ELF1_20517297_ChIP-Seq_JURKAT_Human1.45003862
86IKZF1_21737484_ChIP-ChIP_HCT116_Human1.44618428
87TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.43466269
88TTF2_22483619_ChIP-Seq_HELA_Human1.42473108
89ZNF263_19887448_ChIP-Seq_K562_Human1.42361584
90DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.41966343
91MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.41933209
92PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.40648815
93P68_20966046_ChIP-Seq_HELA_Human1.40038832
94CTCF_18555785_ChIP-Seq_MESCs_Mouse1.39084193
95TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.38560570
96TOP2B_26459242_ChIP-Seq_MCF-7_Human1.37913079
97IGF1R_20145208_ChIP-Seq_DFB_Human1.36722548
98ER_23166858_ChIP-Seq_MCF-7_Human1.36641076
99KDM5A_27292631_Chip-Seq_BREAST_Human1.35426813
100FOXP1_21924763_ChIP-Seq_HESCs_Human1.34263632
101SMAD3_21741376_ChIP-Seq_EPCs_Human1.33753248
102LXR_22292898_ChIP-Seq_THP-1_Human1.33227198
103* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.32792464
104FUS_26573619_Chip-Seq_HEK293_Human1.31271428
105SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.29102116
106PIAS1_25552417_ChIP-Seq_VCAP_Human1.28628140
107RNF2_27304074_Chip-Seq_NSC_Mouse1.28032204
108HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.25615873
109ZFX_18555785_ChIP-Seq_MESCs_Mouse1.25584186
110NR3C1_23031785_ChIP-Seq_PC12_Mouse1.25180843
111SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.25170064
112SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.23287164
113SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.22965089
114RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.22776497
115SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.21303988
116NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.20399950
117BCL6_27268052_Chip-Seq_Bcells_Human1.20396315
118PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.20279078
119STAT3_1855785_ChIP-Seq_MESCs_Mouse1.20216252
120TBX5_21415370_ChIP-Seq_HL-1_Mouse1.19658967
121THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.18531128
122ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.16735674
123SOX2_21211035_ChIP-Seq_LN229_Gbm1.16609578
124FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.16589586
125YY1_22570637_ChIP-Seq_MALME-3M_Human1.16244703
126BCOR_27268052_Chip-Seq_Bcells_Human1.16183924
127DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.16028318
128KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.15881612
129AR_25329375_ChIP-Seq_VCAP_Human1.14855316
130ERG_21242973_ChIP-ChIP_JURKAT_Human1.14824384
131HOXB4_20404135_ChIP-ChIP_EML_Mouse1.14553349
132TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12963585
133PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12530934
134CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.12352912
135PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.12064639
136PPARA_22158963_ChIP-Seq_LIVER_Mouse1.11997586
137ZNF274_21170338_ChIP-Seq_K562_Hela1.11978293
138HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.11747994
139* CTCF_26484167_Chip-Seq_Bcells_Mouse1.11107999
140MYCN_18555785_ChIP-Seq_MESCs_Mouse1.10444184
141UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.10283082
142RARG_19884340_ChIP-ChIP_MEFs_Mouse1.10053214
143E2F1_20622854_ChIP-Seq_HELA_Human1.09030323
144HTT_18923047_ChIP-ChIP_STHdh_Human1.08610603
145CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.07763893
146RARB_24833708_ChIP-Seq_LIVER_Mouse1.07506501
147RACK7_27058665_Chip-Seq_MCF-7_Human1.07500131
148PHF8_20622854_ChIP-Seq_HELA_Human1.06638359
149MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.06496457
150THAP11_20581084_ChIP-Seq_MESCs_Mouse1.06402170
151CTCF_20526341_ChIP-Seq_ESCs_Human1.06374460
152RXR_22158963_ChIP-Seq_LIVER_Mouse1.05526404
153POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.05203560
154SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.04789770
155CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04531364
156* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.04117726
157SA1_27219007_Chip-Seq_Bcells_Human1.03720188
158TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03102319
159JUN_21703547_ChIP-Seq_K562_Human1.02810753
160FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.02570995
161* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.02179027
162SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.02015970
163SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.01612166
164SA1_27219007_Chip-Seq_ERYTHROID_Human1.00847436
165P53_22127205_ChIP-Seq_FIBROBLAST_Human1.00779253
166STAT3_23295773_ChIP-Seq_U87_Human0.97869089
167MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97717099
168PRDM14_20953172_ChIP-Seq_ESCs_Human0.97679859
169SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.97582985
170POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.96435573
171TCF4_23295773_ChIP-Seq_U87_Human0.95772894
172DNAJC2_21179169_ChIP-ChIP_NT2_Human0.95115599
173KLF4_18555785_ChIP-Seq_MESCs_Mouse0.95007285
174SOX9_26525672_Chip-Seq_HEART_Mouse0.94036104
175SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.93661191
176RUNX2_22187159_ChIP-Seq_PCA_Human0.91459387
177RING1B_27294783_Chip-Seq_ESCs_Mouse0.90042650
178GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.87813429
179E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.87771858
180TAL1_26923725_Chip-Seq_HPCs_Mouse0.86998559
181NANOG_18555785_Chip-Seq_ESCs_Mouse0.85860745
182HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.83815744
183CDX2_19796622_ChIP-Seq_MESCs_Mouse0.83723074
184RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.83047434
185NANOG_19829295_ChIP-Seq_ESCs_Human0.79886044
186SOX2_19829295_ChIP-Seq_ESCs_Human0.79886044
187REST_19997604_ChIP-ChIP_NEURONS_Mouse0.79839667
188NR3C1_21868756_ChIP-Seq_MCF10A_Human0.79102431
189ARNT_22903824_ChIP-Seq_MCF-7_Human0.78580768
190EP300_21415370_ChIP-Seq_HL-1_Mouse0.78374216
191AR_19668381_ChIP-Seq_PC3_Human0.77772343
192AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.77501126
193TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.76999610

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.70637745
2MP0009840_abnormal_foam_cell4.26975107
3MP0003806_abnormal_nucleotide_metabolis3.74979780
4MP0004859_abnormal_synaptic_plasticity3.60540449
5MP0001529_abnormal_vocalization3.23831591
6MP0009046_muscle_twitch3.22790479
7MP0000372_irregular_coat_pigmentation3.13196764
8MP0003635_abnormal_synaptic_transmissio3.12304453
9MP0002064_seizures3.00067455
10MP0004270_analgesia2.94226737
11MP0005670_abnormal_white_adipose2.91274999
12MP0009745_abnormal_behavioral_response2.88543298
13MP0003191_abnormal_cellular_cholesterol2.87482470
14MP0003186_abnormal_redox_activity2.78202259
15MP0002272_abnormal_nervous_system2.75787952
16MP0001968_abnormal_touch/_nociception2.72632918
17MP0005058_abnormal_lysosome_morphology2.71048802
18MP0002736_abnormal_nociception_after2.61768301
19MP0006276_abnormal_autonomic_nervous2.51235470
20MP0002063_abnormal_learning/memory/cond2.50704594
21MP0002572_abnormal_emotion/affect_behav2.49931469
22MP0003122_maternal_imprinting2.41624178
23MP0002734_abnormal_mechanical_nocicepti2.37673892
24MP0001905_abnormal_dopamine_level2.33495270
25MP0004142_abnormal_muscle_tone2.33049775
26MP0001486_abnormal_startle_reflex2.27594248
27MP0002735_abnormal_chemical_nociception2.18175493
28MP0005075_abnormal_melanosome_morpholog2.11974605
29MP0003693_abnormal_embryo_hatching2.09862564
30MP0008875_abnormal_xenobiotic_pharmacok2.08232220
31MP0002837_dystrophic_cardiac_calcinosis2.06886859
32MP0001440_abnormal_grooming_behavior2.04366107
33MP0005423_abnormal_somatic_nervous2.01386499
34MP0008058_abnormal_DNA_repair1.98976791
35MP0002067_abnormal_sensory_capabilities1.96416006
36MP0005646_abnormal_pituitary_gland1.95316298
37MP0001764_abnormal_homeostasis1.93787983
38MP0002822_catalepsy1.93570731
39MP0001501_abnormal_sleep_pattern1.90336680
40MP0002938_white_spotting1.87593707
41MP0001970_abnormal_pain_threshold1.82903077
42MP0001984_abnormal_olfaction1.78431893
43MP0000751_myopathy1.78304574
44MP0002733_abnormal_thermal_nociception1.78173121
45MP0004924_abnormal_behavior1.77076598
46MP0005386_behavior/neurological_phenoty1.77076598
47MP0002139_abnormal_hepatobiliary_system1.71982818
48MP0003329_amyloid_beta_deposits1.71402623
49MP0003786_premature_aging1.69190739
50MP0003123_paternal_imprinting1.68037495
51MP0000778_abnormal_nervous_system1.61951063
52MP0010329_abnormal_lipoprotein_level1.60666731
53MP0000920_abnormal_myelination1.60481969
54MP0008569_lethality_at_weaning1.59875770
55MP0005332_abnormal_amino_acid1.57660412
56MP0002557_abnormal_social/conspecific_i1.53326904
57MP0002184_abnormal_innervation1.51334954
58MP0005408_hypopigmentation1.46458902
59MP0005636_abnormal_mineral_homeostasis1.46132733
60MP0003195_calcinosis1.46050593
61MP0003718_maternal_effect1.43199705
62MP0003136_yellow_coat_color1.42829768
63MP0005645_abnormal_hypothalamus_physiol1.41491936
64MP0010030_abnormal_orbit_morphology1.37387385
65MP0003787_abnormal_imprinting1.36726036
66MP0005365_abnormal_bile_salt1.36535101
67MP0002066_abnormal_motor_capabilities/c1.36489238
68MP0005330_cardiomyopathy1.35502780
69MP0010094_abnormal_chromosome_stability1.35409704
70MP0002882_abnormal_neuron_morphology1.33413832
71MP0000955_abnormal_spinal_cord1.32189976
72MP0003011_delayed_dark_adaptation1.28720217
73MP0000015_abnormal_ear_pigmentation1.28628158
74MP0002229_neurodegeneration1.27673242
75MP0005551_abnormal_eye_electrophysiolog1.26940957
76MP0003111_abnormal_nucleus_morphology1.22223860
77MP0003646_muscle_fatigue1.22010287
78MP0001502_abnormal_circadian_rhythm1.18770232
79MP0005501_abnormal_skin_physiology1.17199486
80MP0005171_absent_coat_pigmentation1.16884770
81MP0000003_abnormal_adipose_tissue1.15938425
82MP0004811_abnormal_neuron_physiology1.15357477
83MP0004742_abnormal_vestibular_system1.14177027
84MP0009697_abnormal_copulation1.13677728
85MP0001188_hyperpigmentation1.13172010
86MP0004215_abnormal_myocardial_fiber1.12521371
87MP0010234_abnormal_vibrissa_follicle1.11593421
88MP0009780_abnormal_chondrocyte_physiolo1.11425720
89MP0005410_abnormal_fertilization1.11174684
90MP0002090_abnormal_vision1.10772763
91MP0004957_abnormal_blastocyst_morpholog1.10583994
92MP0000358_abnormal_cell_content/1.10471197
93MP0002796_impaired_skin_barrier1.10384402
94MP0005584_abnormal_enzyme/coenzyme_acti1.09438638
95MP0003634_abnormal_glial_cell1.09047852
96MP0004858_abnormal_nervous_system1.08900330
97MP0004145_abnormal_muscle_electrophysio1.07484926
98MP0001346_abnormal_lacrimal_gland1.07431619
99MP0003690_abnormal_glial_cell1.07339998
100MP0002876_abnormal_thyroid_physiology1.06554835
101MP0004885_abnormal_endolymph1.05113705
102MP0003631_nervous_system_phenotype1.04985760
103MP0004019_abnormal_vitamin_homeostasis1.04469383
104MP0008872_abnormal_physiological_respon1.04207506
105MP0000749_muscle_degeneration1.04117162
106MP0003633_abnormal_nervous_system1.03858396
107MP0004036_abnormal_muscle_relaxation1.03441146
108MP0004043_abnormal_pH_regulation1.02786663
109MP0002118_abnormal_lipid_homeostasis1.02036459
110MP0002095_abnormal_skin_pigmentation1.01662260
111MP0006035_abnormal_mitochondrial_morpho1.01211980
112MP0006036_abnormal_mitochondrial_physio1.01143786
113MP0001986_abnormal_taste_sensitivity1.00122527
114MP0003137_abnormal_impulse_conducting0.97448806
115MP0000639_abnormal_adrenal_gland0.97058084
116MP0004381_abnormal_hair_follicle0.96760078
117MP0001963_abnormal_hearing_physiology0.96256833
118MP0009643_abnormal_urine_homeostasis0.96228446
119MP0004085_abnormal_heartbeat0.96093550
120MP0002163_abnormal_gland_morphology0.96019197
121MP0003632_abnormal_nervous_system0.94582532
122MP0003879_abnormal_hair_cell0.93015901
123MP0000647_abnormal_sebaceous_gland0.92605619
124MP0008932_abnormal_embryonic_tissue0.92305387
125MP0002752_abnormal_somatic_nervous0.92097056
126MP0005379_endocrine/exocrine_gland_phen0.91559213
127MP0005165_increased_susceptibility_to0.91080361
128MP0008007_abnormal_cellular_replicative0.91051886
129MP0003638_abnormal_response/metabolism_0.91019120
130MP0005083_abnormal_biliary_tract0.90958941
131MP0001485_abnormal_pinna_reflex0.90919266
132MP0003075_altered_response_to0.90144679
133MP0005451_abnormal_body_composition0.89191770
134MP0005394_taste/olfaction_phenotype0.88146564
135MP0005499_abnormal_olfactory_system0.88146564
136MP0002909_abnormal_adrenal_gland0.85507836
137MP0000579_abnormal_nail_morphology0.85495926
138MP0002152_abnormal_brain_morphology0.85182427
139MP0005452_abnormal_adipose_tissue0.84887738
140MP0000013_abnormal_adipose_tissue0.84778168
141MP0003183_abnormal_peptide_metabolism0.83986118
142MP0004147_increased_porphyrin_level0.81755008
143MP0002069_abnormal_eating/drinking_beha0.81167680
144MP0001664_abnormal_digestion0.79941554
145MP0002970_abnormal_white_adipose0.79092937
146MP0010771_integument_phenotype0.78261750
147MP0000747_muscle_weakness0.78025010
148MP0000631_abnormal_neuroendocrine_gland0.75808168
149MP0004233_abnormal_muscle_weight0.75101367
150MP0005535_abnormal_body_temperature0.74487968
151MP0000566_synostosis0.74296823
152MP0002751_abnormal_autonomic_nervous0.73909707
153MP0005367_renal/urinary_system_phenotyp0.73871047
154MP0000516_abnormal_urinary_system0.73871047
155MP0003878_abnormal_ear_physiology0.72537608
156MP0005377_hearing/vestibular/ear_phenot0.72537608
157MP0005253_abnormal_eye_physiology0.72065067
158MP0003121_genomic_imprinting0.71991067
159MP0005375_adipose_tissue_phenotype0.71744831
160MP0010386_abnormal_urinary_bladder0.71536564
161MP0006072_abnormal_retinal_apoptosis0.70553179
162MP0002332_abnormal_exercise_endurance0.70510966
163MP0002638_abnormal_pupillary_reflex0.70197660
164MP0005409_darkened_coat_color0.68923935
165MP0008877_abnormal_DNA_methylation0.67160013
166MP0002653_abnormal_ependyma_morphology0.66512613
167MP0000026_abnormal_inner_ear0.63350766

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.44105362
2Acute necrotizing encephalopathy (HP:0006965)5.07683220
3Abnormal mitochondria in muscle tissue (HP:0008316)4.81260119
4Pheochromocytoma (HP:0002666)4.66281172
5Myokymia (HP:0002411)4.50469250
6Mitochondrial inheritance (HP:0001427)4.33899594
7Neuroendocrine neoplasm (HP:0100634)4.33761013
8Atonic seizures (HP:0010819)4.27421333
9Progressive macrocephaly (HP:0004481)4.22983790
10Acute encephalopathy (HP:0006846)4.18088588
11Hepatocellular necrosis (HP:0001404)4.11502009
12Epileptic encephalopathy (HP:0200134)4.02481232
13Abnormality of glycolysis (HP:0004366)3.98841018
14Increased serum pyruvate (HP:0003542)3.98841018
15Type I transferrin isoform profile (HP:0003642)3.79260018
16Increased CSF lactate (HP:0002490)3.73751162
17Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.64668418
18Focal seizures (HP:0007359)3.44882542
19Hepatic necrosis (HP:0002605)3.33408116
20Hyperventilation (HP:0002883)3.32842629
21Leukodystrophy (HP:0002415)3.24896228
22Febrile seizures (HP:0002373)3.21644107
23Abnormal hair whorl (HP:0010721)3.21000098
24Abnormal protein glycosylation (HP:0012346)3.10774515
25Abnormal glycosylation (HP:0012345)3.10774515
26Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.10774515
27Abnormal protein N-linked glycosylation (HP:0012347)3.10774515
28Absence seizures (HP:0002121)3.02886693
29Increased muscle lipid content (HP:0009058)2.96593317
30Abnormality of aromatic amino acid family metabolism (HP:0004338)2.91306722
31Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.89192578
32Degeneration of the lateral corticospinal tracts (HP:0002314)2.89192578
33Progressive cerebellar ataxia (HP:0002073)2.85650513
34Dialeptic seizures (HP:0011146)2.84911700
35Limb dystonia (HP:0002451)2.82133114
36Cerebral edema (HP:0002181)2.79164176
37Hypokinesia (HP:0002375)2.74764340
38Gait imbalance (HP:0002141)2.74550123
39Abnormality of dicarboxylic acid metabolism (HP:0010995)2.74490342
40Dicarboxylic aciduria (HP:0003215)2.74490342
41Polyphagia (HP:0002591)2.74197810
42Optic disc pallor (HP:0000543)2.73094955
43Visual hallucinations (HP:0002367)2.73016346
44Poor suck (HP:0002033)2.70258470
45Respiratory failure (HP:0002878)2.66231980
46Generalized tonic-clonic seizures (HP:0002069)2.65538620
47Testicular atrophy (HP:0000029)2.65159719
48Rhabdomyolysis (HP:0003201)2.64296864
49Lactic acidosis (HP:0003128)2.58866779
50Abnormality of the corticospinal tract (HP:0002492)2.57697613
51Congenital primary aphakia (HP:0007707)2.56682794
52Medial flaring of the eyebrow (HP:0010747)2.52879414
53Abnormal eating behavior (HP:0100738)2.47078643
54Opisthotonus (HP:0002179)2.46779191
55Sparse eyelashes (HP:0000653)2.44245443
56Nephrogenic diabetes insipidus (HP:0009806)2.43747113
57Failure to thrive in infancy (HP:0001531)2.43422325
58Methylmalonic aciduria (HP:0012120)2.43127419
59Sensory axonal neuropathy (HP:0003390)2.42470139
60Tongue fasciculations (HP:0001308)2.41614684
61Ankle clonus (HP:0011448)2.41061003
62Anxiety (HP:0000739)2.40958862
63Vaginal atresia (HP:0000148)2.40401811
64Reduced antithrombin III activity (HP:0001976)2.40317535
65Broad-based gait (HP:0002136)2.38615520
66Lethargy (HP:0001254)2.37941185
67Genital tract atresia (HP:0001827)2.37283603
68Cerebral hypomyelination (HP:0006808)2.34814802
69Exercise intolerance (HP:0003546)2.34684664
70Renal Fanconi syndrome (HP:0001994)2.31957362
71Abnormality of alanine metabolism (HP:0010916)2.31893816
72Hyperalaninemia (HP:0003348)2.31893816
73Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.31893816
74Myoglobinuria (HP:0002913)2.30773057
75Hypothermia (HP:0002045)2.29456702
76Cholecystitis (HP:0001082)2.29189575
77Abnormal gallbladder physiology (HP:0012438)2.29189575
78Oligomenorrhea (HP:0000876)2.28954192
79Hypoglycemic coma (HP:0001325)2.28626729
80Microvesicular hepatic steatosis (HP:0001414)2.26852997
81Dysmetria (HP:0001310)2.26521770
82Myopathic facies (HP:0002058)2.26431390
83Neurofibrillary tangles (HP:0002185)2.25467440
84Ragged-red muscle fibers (HP:0003200)2.24725568
85Spastic gait (HP:0002064)2.22286057
86Scanning speech (HP:0002168)2.22174314
87Prolonged neonatal jaundice (HP:0006579)2.21687225
88Microretrognathia (HP:0000308)2.20248931
89Supranuclear gaze palsy (HP:0000605)2.19525522
90Neoplasm of the peripheral nervous system (HP:0100007)2.16802057
91Increased serum lactate (HP:0002151)2.16453708
92Emotional lability (HP:0000712)2.16040204
93Spastic paraparesis (HP:0002313)2.14704343
94Degeneration of anterior horn cells (HP:0002398)2.13651774
95Abnormality of the anterior horn cell (HP:0006802)2.13651774
96Progressive microcephaly (HP:0000253)2.13222067
97Patchy hypopigmentation of hair (HP:0011365)2.12062599
98Cerebral palsy (HP:0100021)2.11748094
99Increased hepatocellular lipid droplets (HP:0006565)2.11543761
100Specific learning disability (HP:0001328)2.07985253
101Ketoacidosis (HP:0001993)2.07822165
102Epileptiform EEG discharges (HP:0011182)2.05404321
103X-linked dominant inheritance (HP:0001423)2.04943371
104CNS hypomyelination (HP:0003429)2.03437570
105Truncal ataxia (HP:0002078)2.02988930
106Congenital ichthyosiform erythroderma (HP:0007431)2.02718265
1073-Methylglutaconic aciduria (HP:0003535)2.01402630
108Dysdiadochokinesis (HP:0002075)2.00056957
109Parakeratosis (HP:0001036)2.00019553
110Abnormal gallbladder morphology (HP:0012437)2.00000877
111Gaze-evoked nystagmus (HP:0000640)1.99592580
112Exercise-induced muscle cramps (HP:0003710)1.99373376
113Large for gestational age (HP:0001520)1.99169966
114Increased intramyocellular lipid droplets (HP:0012240)1.98150612
115Vacuolated lymphocytes (HP:0001922)1.97878705
116Methylmalonic acidemia (HP:0002912)1.97428787
117CNS demyelination (HP:0007305)1.93945346
118Gout (HP:0001997)1.93718405
119Hyperammonemia (HP:0001987)1.92081311
120Progressive inability to walk (HP:0002505)1.90904215
121Action tremor (HP:0002345)1.90571487
122EEG with generalized epileptiform discharges (HP:0011198)1.89891226
123Muscle hypertrophy of the lower extremities (HP:0008968)1.89361958
124Ketosis (HP:0001946)1.88862304
125Narrow nasal bridge (HP:0000446)1.88658522
126Cholelithiasis (HP:0001081)1.87908225
127Cerebral hemorrhage (HP:0001342)1.87900616
128Gliosis (HP:0002171)1.87436105
129Abnormal pupillary function (HP:0007686)1.87430003
130Hypoglycemic seizures (HP:0002173)1.86698376
131Esotropia (HP:0000565)1.86174963
132Psychosis (HP:0000709)1.85868214
133Abnormality of the labia minora (HP:0012880)1.85075361
134Poor coordination (HP:0002370)1.84767481
135Exercise-induced myalgia (HP:0003738)1.84140917
136Lipid accumulation in hepatocytes (HP:0006561)1.83998506
137Delayed CNS myelination (HP:0002188)1.83870022
138Muscle fibrillation (HP:0010546)1.83058299
139Fasciculations (HP:0002380)1.82831435
140Impaired vibration sensation in the lower limbs (HP:0002166)1.81474494
141Hypsarrhythmia (HP:0002521)1.81335623
142Poor speech (HP:0002465)1.81060511
143Respiratory difficulties (HP:0002880)1.78032283
144Hypoplasia of the capital femoral epiphysis (HP:0003090)1.76790148
145Unsteady gait (HP:0002317)1.76718251
146Generalized aminoaciduria (HP:0002909)1.76628899
147White forelock (HP:0002211)1.76615294
148Termporal pattern (HP:0011008)1.76572846
149Insidious onset (HP:0003587)1.76572846
150Akinesia (HP:0002304)1.76030899
151Delusions (HP:0000746)1.75903595
152Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.75820289
153Abnormality of magnesium homeostasis (HP:0004921)1.74248982
154Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.73499923
155Distal lower limb muscle weakness (HP:0009053)1.73435508
156Fetal akinesia sequence (HP:0001989)1.73209108
157Progressive muscle weakness (HP:0003323)1.72885609
158Calf muscle hypertrophy (HP:0008981)1.72424077
159Depression (HP:0000716)1.71533529
160Pancytopenia (HP:0001876)1.69571001
161Cerebral inclusion bodies (HP:0100314)1.69339788
162Hyperinsulinemic hypoglycemia (HP:0000825)1.68592950
163Decreased activity of mitochondrial respiratory chain (HP:0008972)1.68310387
164Abnormality of the gallbladder (HP:0005264)1.65774453
165Vomiting (HP:0002013)1.65141618
166Xanthomatosis (HP:0000991)1.63800026

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.57550100
2CASK4.47378956
3MAP3K123.89295724
4NME23.88599275
5TESK23.81075252
6BUB13.46622464
7TESK13.20530874
8CDK193.01113472
9NTRK32.99687827
10OXSR12.71494371
11MAP2K72.52783864
12STK392.43653868
13PIM22.43585003
14MAP3K42.41809372
15EPHA22.34637547
16MAPKAPK32.27927682
17PBK2.17599853
18PRPF4B2.12953071
19MINK11.94717364
20EPHA41.93422626
21BCR1.81795214
22MARK11.76847511
23NME11.73108421
24TNIK1.70850249
25KDR1.65799119
26MAP2K41.62998787
27PLK21.62575899
28EIF2AK11.58622708
29MYLK1.55188500
30NTRK21.54671910
31LIMK11.49770974
32UHMK11.49676317
33MAPK131.48594580
34ARAF1.47410767
35SIK31.44935143
36PHKG21.43482953
37PHKG11.43482953
38BRSK11.42519555
39TSSK61.41641254
40CCNB11.40257451
41SGK2231.39674305
42SGK4941.39674305
43VRK11.37718803
44WNK41.35605592
45AKT31.34120973
46DAPK11.28895204
47CAMK2B1.28732857
48ABL21.28628357
49MAPKAPK51.28315309
50MAP3K111.27673312
51CAMK2A1.21282578
52MAP3K91.20241741
53PRKCG1.18914528
54GRK71.17308212
55GRK51.17199797
56MST1R1.16131564
57DAPK21.15896033
58PNCK1.11537233
59CDK51.07926759
60CAMK2D1.05967376
61CSNK1G31.05683605
62ERN11.02619881
63CDK181.01690384
64SMG11.01019360
65MAP4K20.99474469
66STK160.98852793
67LMTK20.97966727
68TRIM280.97960077
69CDK140.96622175
70MUSK0.95983823
71ADRBK20.95764607
72WNK10.94820945
73ROCK20.94627921
74PAK60.94266452
75CDK150.93306086
76CAMK2G0.93061108
77BRAF0.92122773
78CSNK1G20.91968549
79NTRK10.91749529
80PKN10.91012497
81PDK30.89665703
82PDK40.89665703
83MAP2K60.88727875
84PRKCI0.86846568
85BMPR1B0.86788523
86PRKCE0.86302699
87WEE10.86301527
88PAK40.85720736
89SCYL20.82989141
90CDK11A0.82415708
91PRKD30.81672042
92OBSCN0.80145551
93ADRBK10.77829746
94SGK20.77206804
95PLK30.75461240
96WNK30.71483070
97NEK60.71437176
98PAK10.70208585
99AURKA0.69814690
100TTK0.69798789
101NUAK10.67438789
102PLK10.66845949
103IRAK30.66084502
104SRPK10.65738749
105NEK10.65439155
106KSR10.64720737
107PINK10.63998926
108CAMKK20.63837814
109PAK30.62631327
110MAPK110.61826289
111LRRK20.59325475
112AKT20.58370984
113TAOK20.58181881
114ZAK0.57983617
115ATR0.57642458
116DAPK30.57113927
117ILK0.55901298
118MAP3K30.54275986
119TNK20.54046639
120CSNK1G10.53597123
121PRKACA0.52800804
122SIK10.52620013
123DYRK20.51131515
124PDK20.50417221
125CAMK10.45890029
126BCKDK0.45765569
127CSNK1A1L0.45226205
128PRKCH0.45001574
129DYRK1A0.44329174
130RPS6KB20.42306224
131CDK70.42282218
132CSNK2A10.42063512
133BMPR20.41810554
134PRKACB0.41286764
135PTK2B0.41270631
136CDK80.41225814
137AURKB0.40688193
138PRKG10.40584775
139FES0.39377458
140STK100.38610616
141ERBB40.37680854
142CSNK2A20.36818607
143FGFR20.36516971
144MST40.36109250
145PRKCA0.34586974
146CSNK1A10.33489057
147PDPK10.32558838
148SGK10.32024051
149ROCK10.31761388
150SGK30.31409754
151CHEK20.29524070
152FER0.29261030
153CDC70.28276109
154EIF2AK20.24995775
155TBK10.24806567
156STK40.24327004
157RPS6KA50.22424005

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.30315453
2Parkinsons disease_Homo sapiens_hsa050123.45753071
3Synaptic vesicle cycle_Homo sapiens_hsa047213.40781624
4Collecting duct acid secretion_Homo sapiens_hsa049663.18461849
5Nicotine addiction_Homo sapiens_hsa050333.17088843
6Alzheimers disease_Homo sapiens_hsa050102.68041034
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.46623016
8Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.44954241
9Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.26740469
10DNA replication_Homo sapiens_hsa030302.23919066
11Huntingtons disease_Homo sapiens_hsa050162.22352084
12GABAergic synapse_Homo sapiens_hsa047272.18209456
13Vibrio cholerae infection_Homo sapiens_hsa051102.14371237
14Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.11300161
15Sulfur relay system_Homo sapiens_hsa041222.07993286
16Cardiac muscle contraction_Homo sapiens_hsa042602.01897352
17Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.93489594
18Base excision repair_Homo sapiens_hsa034101.90824102
19* Fatty acid elongation_Homo sapiens_hsa000621.87867117
20RNA polymerase_Homo sapiens_hsa030201.84441207
21Glutathione metabolism_Homo sapiens_hsa004801.82276677
22Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.76562591
23Morphine addiction_Homo sapiens_hsa050321.75559539
24Circadian entrainment_Homo sapiens_hsa047131.73359775
25Folate biosynthesis_Homo sapiens_hsa007901.71103223
26Mismatch repair_Homo sapiens_hsa034301.70895680
27Steroid biosynthesis_Homo sapiens_hsa001001.65237172
28Pyruvate metabolism_Homo sapiens_hsa006201.62966432
29Glutamatergic synapse_Homo sapiens_hsa047241.58134156
30Butanoate metabolism_Homo sapiens_hsa006501.55691813
31Amphetamine addiction_Homo sapiens_hsa050311.53881709
32Pentose phosphate pathway_Homo sapiens_hsa000301.50162659
33Serotonergic synapse_Homo sapiens_hsa047261.49658752
34Pyrimidine metabolism_Homo sapiens_hsa002401.49542592
35Olfactory transduction_Homo sapiens_hsa047401.46567880
36Dopaminergic synapse_Homo sapiens_hsa047281.46516436
37Taste transduction_Homo sapiens_hsa047421.45751469
382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.45736301
39Ribosome_Homo sapiens_hsa030101.42540004
40Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.30379423
41Cyanoamino acid metabolism_Homo sapiens_hsa004601.27412442
42Homologous recombination_Homo sapiens_hsa034401.27113725
43Cocaine addiction_Homo sapiens_hsa050301.27049966
44* Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.24807522
45Long-term potentiation_Homo sapiens_hsa047201.23783962
46Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.23762854
47Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.23124176
48Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.21954309
49Primary bile acid biosynthesis_Homo sapiens_hsa001201.20834305
50Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.19238380
51Insulin secretion_Homo sapiens_hsa049111.18344814
52Galactose metabolism_Homo sapiens_hsa000521.18201360
53Propanoate metabolism_Homo sapiens_hsa006401.17149217
54Long-term depression_Homo sapiens_hsa047301.14940422
55Salivary secretion_Homo sapiens_hsa049701.14551775
56Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.08788357
57Proteasome_Homo sapiens_hsa030501.07847348
58Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.06525617
59Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.05855645
60Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.05014216
61N-Glycan biosynthesis_Homo sapiens_hsa005101.04704491
62Cholinergic synapse_Homo sapiens_hsa047251.02698706
63Arginine biosynthesis_Homo sapiens_hsa002201.00426062
64Nucleotide excision repair_Homo sapiens_hsa034201.00413024
65Purine metabolism_Homo sapiens_hsa002300.98871776
66Calcium signaling pathway_Homo sapiens_hsa040200.97661030
67Fatty acid degradation_Homo sapiens_hsa000710.94664233
68Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.93310497
69Sulfur metabolism_Homo sapiens_hsa009200.93112605
70Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.91079016
71Gastric acid secretion_Homo sapiens_hsa049710.90993744
72Rheumatoid arthritis_Homo sapiens_hsa053230.90009968
73Renin secretion_Homo sapiens_hsa049240.87629433
74Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.86908184
75One carbon pool by folate_Homo sapiens_hsa006700.85032370
76Carbon metabolism_Homo sapiens_hsa012000.84010760
77Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.83229991
78Protein export_Homo sapiens_hsa030600.82873405
79Other glycan degradation_Homo sapiens_hsa005110.82603430
80SNARE interactions in vesicular transport_Homo sapiens_hsa041300.79696739
81Phototransduction_Homo sapiens_hsa047440.79436109
82Fat digestion and absorption_Homo sapiens_hsa049750.79315130
83Vitamin digestion and absorption_Homo sapiens_hsa049770.78426213
84Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.78217723
85Axon guidance_Homo sapiens_hsa043600.76844454
86Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.74962235
87Spliceosome_Homo sapiens_hsa030400.73448687
88Maturity onset diabetes of the young_Homo sapiens_hsa049500.72899936
89Aldosterone synthesis and secretion_Homo sapiens_hsa049250.72037459
90Nitrogen metabolism_Homo sapiens_hsa009100.71156791
91Phenylalanine metabolism_Homo sapiens_hsa003600.70744047
92Ether lipid metabolism_Homo sapiens_hsa005650.70434849
93Phagosome_Homo sapiens_hsa041450.70355418
94Tryptophan metabolism_Homo sapiens_hsa003800.67181289
95Gap junction_Homo sapiens_hsa045400.66716472
96Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.64994475
97Oxytocin signaling pathway_Homo sapiens_hsa049210.64865651
98Pentose and glucuronate interconversions_Homo sapiens_hsa000400.64163853
99Tyrosine metabolism_Homo sapiens_hsa003500.63993867
100PPAR signaling pathway_Homo sapiens_hsa033200.63676187
101Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.61498432
102Chemical carcinogenesis_Homo sapiens_hsa052040.61441314
103Glycosaminoglycan degradation_Homo sapiens_hsa005310.60736989
104Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.60360341
105Fanconi anemia pathway_Homo sapiens_hsa034600.60342633
106Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.57175284
107Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.56426858
108Drug metabolism - other enzymes_Homo sapiens_hsa009830.55785718
109Metabolic pathways_Homo sapiens_hsa011000.55443719
110Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.51334646
111* Fatty acid metabolism_Homo sapiens_hsa012120.50508189
112Lysosome_Homo sapiens_hsa041420.49937645
113Dilated cardiomyopathy_Homo sapiens_hsa054140.47266767
114Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.47251129
115Biosynthesis of amino acids_Homo sapiens_hsa012300.47221492
116Cysteine and methionine metabolism_Homo sapiens_hsa002700.47021591
117cAMP signaling pathway_Homo sapiens_hsa040240.47014326
118Vitamin B6 metabolism_Homo sapiens_hsa007500.46868363
119Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.46276310
120Vascular smooth muscle contraction_Homo sapiens_hsa042700.44139904
121Peroxisome_Homo sapiens_hsa041460.43471875
122Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.39806919
123Non-homologous end-joining_Homo sapiens_hsa034500.39713081
124RNA transport_Homo sapiens_hsa030130.36837282
125cGMP-PKG signaling pathway_Homo sapiens_hsa040220.32053508
126Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.31411971
127Arginine and proline metabolism_Homo sapiens_hsa003300.31271087
128GnRH signaling pathway_Homo sapiens_hsa049120.31049491
129Regulation of autophagy_Homo sapiens_hsa041400.31032473
130Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.30420105
131Melanogenesis_Homo sapiens_hsa049160.29079578
132alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.28780125
133Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.27651413
134Arachidonic acid metabolism_Homo sapiens_hsa005900.27610224
135RNA degradation_Homo sapiens_hsa030180.27479337
136Pancreatic secretion_Homo sapiens_hsa049720.27442260
137Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.26419457
138Fructose and mannose metabolism_Homo sapiens_hsa000510.26240887
139Glucagon signaling pathway_Homo sapiens_hsa049220.26177651
140ErbB signaling pathway_Homo sapiens_hsa040120.25872114
141Histidine metabolism_Homo sapiens_hsa003400.24949603
142Alcoholism_Homo sapiens_hsa050340.24806989
143Steroid hormone biosynthesis_Homo sapiens_hsa001400.23942428
144Glycerolipid metabolism_Homo sapiens_hsa005610.23418027
145Oocyte meiosis_Homo sapiens_hsa041140.22555540
146Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.22314631
147Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.21820601
148Glycerophospholipid metabolism_Homo sapiens_hsa005640.21453323
149Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.21220663
150Sphingolipid metabolism_Homo sapiens_hsa006000.20743776
151Ovarian steroidogenesis_Homo sapiens_hsa049130.20611360
152Thyroid hormone synthesis_Homo sapiens_hsa049180.19687995
153beta-Alanine metabolism_Homo sapiens_hsa004100.19603021

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