ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	protein complex biogenesis (GO:0070271)	4.90493877
2	respiratory chain complex IV assembly (GO:0008535)	4.88327525
3	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.84526867
4	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.79668114
5	cytochrome complex assembly (GO:0017004)	4.77977822
6	DNA deamination (GO:0045006)	4.61570997
7	mitochondrial respiratory chain complex assembly (GO:0033108)	4.52221808
8	ATP synthesis coupled proton transport (GO:0015986)	4.38838886
9	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.38838886
10	proteasome assembly (GO:0043248)	4.38407527
11	platelet dense granule organization (GO:0060155)	4.28529876
12	respiratory electron transport chain (GO:0022904)	4.25654198
13	electron transport chain (GO:0022900)	4.24103138
14	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.91939526
15	mannosylation (GO:0097502)	3.90738553
16	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.89856126
17	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.89856126
18	NADH dehydrogenase complex assembly (GO:0010257)	3.89856126
19	chaperone-mediated protein transport (GO:0072321)	3.88194503
20	cellular ketone body metabolic process (GO:0046950)	3.69440697
21	regulation of mitochondrial translation (GO:0070129)	3.66894016
22	protein-cofactor linkage (GO:0018065)	3.66204389
23	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.48485124
24	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.48485124
25	water-soluble vitamin biosynthetic process (GO:0042364)	3.41176183
26	ketone body metabolic process (GO:1902224)	3.30487065
27	protein neddylation (GO:0045116)	3.30244645
28	maturation of 5.8S rRNA (GO:0000460)	3.22133068
29	ubiquinone biosynthetic process (GO:0006744)	3.18211719
30	cullin deneddylation (GO:0010388)	3.16892150
31	L-phenylalanine catabolic process (GO:0006559)	3.14226987
32	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	3.14226987
33	termination of RNA polymerase III transcription (GO:0006386)	3.12027974
34	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.12027974
35	hydrogen ion transmembrane transport (GO:1902600)	3.07411186
36	protein deneddylation (GO:0000338)	3.06796987
37	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.06630333
38	ubiquinone metabolic process (GO:0006743)	2.99196399
39	proton transport (GO:0015992)	2.97449262
40	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.96424267
41	regulation of cellular amino acid metabolic process (GO:0006521)	2.96344060
42	hydrogen transport (GO:0006818)	2.92858873
43	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	2.91978346
44	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.84564386
45	purine nucleotide salvage (GO:0032261)	2.83960575
46	dolichol-linked oligosaccharide biosynthetic process (GO:0006488)	2.83842702
47	regulation of hexokinase activity (GO:1903299)	2.83548592
48	regulation of glucokinase activity (GO:0033131)	2.83548592
49	metallo-sulfur cluster assembly (GO:0031163)	2.82752542
50	iron-sulfur cluster assembly (GO:0016226)	2.82752542
51	xenobiotic catabolic process (GO:0042178)	2.80780656
52	inositol phosphate catabolic process (GO:0071545)	2.79869034
53	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.79712085
54	inositol phosphate dephosphorylation (GO:0046855)	2.79712085
55	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.78142974
56	preassembly of GPI anchor in ER membrane (GO:0016254)	2.75880003
57	cytidine metabolic process (GO:0046087)	2.71238606
58	cytidine catabolic process (GO:0006216)	2.71238606
59	cytidine deamination (GO:0009972)	2.71238606
60	piRNA metabolic process (GO:0034587)	2.70557461
61	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.69876793
62	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.68691714
63	ATP biosynthetic process (GO:0006754)	2.68223571
64	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	2.67968170
65	L-phenylalanine metabolic process (GO:0006558)	2.67968170
66	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	2.66510527
67	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.66423126
68	positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:00357	2.66322524
69	C-terminal protein lipidation (GO:0006501)	2.66210679
70	deoxyribonucleotide catabolic process (GO:0009264)	2.65787222
71	regulation of cilium movement (GO:0003352)	2.65556291
72	pseudouridine synthesis (GO:0001522)	2.63944876
73	purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)	2.63285473
74	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.62914335
75	energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)	2.61453494
76	ATP hydrolysis coupled proton transport (GO:0015991)	2.61453494
77	glutathione derivative metabolic process (GO:1901685)	2.60925556
78	glutathione derivative biosynthetic process (GO:1901687)	2.60925556
79	quinone biosynthetic process (GO:1901663)	2.60916877
80	inner mitochondrial membrane organization (GO:0007007)	2.60406075
81	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.57869223
82	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.57869223
83	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.57869223
84	adenosine metabolic process (GO:0046085)	2.56673219
85	rRNA modification (GO:0000154)	2.56413984
86	aldehyde catabolic process (GO:0046185)	2.56282846
87	branched-chain amino acid catabolic process (GO:0009083)	2.55582686
88	oxidative phosphorylation (GO:0006119)	2.54618061
89	aromatic amino acid family catabolic process (GO:0009074)	2.53224652
90	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.53184479
91	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.53184479
92	positive regulation of prostaglandin secretion (GO:0032308)	2.51966558
93	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	2.50678410
94	fucose catabolic process (GO:0019317)	2.50594567
95	L-fucose metabolic process (GO:0042354)	2.50594567
96	L-fucose catabolic process (GO:0042355)	2.50594567
97	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.50237968
98	signal peptide processing (GO:0006465)	2.49858635
99	DNA double-strand break processing (GO:0000729)	2.48909793
100	fatty acid elongation (GO:0030497)	2.47744844

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.59349755
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.88800569
3	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.38426359
4	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.34615573
5	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.15928199
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.14095444
7	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.00138112
8	ZNF274_21170338_ChIP-Seq_K562_Hela	2.91827397
9	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.56490226
10	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.55420834
11	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.54669264
12	VDR_23849224_ChIP-Seq_CD4+_Human	2.39846730
13	VDR_22108803_ChIP-Seq_LS180_Human	2.37599354
14	IGF1R_20145208_ChIP-Seq_DFB_Human	2.17707943
15	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.17331535
16	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.14305120
17	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	2.13034138
18	ELK1_19687146_ChIP-ChIP_HELA_Human	2.10566685
19	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.02869153
20	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.01323149
21	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.92579890
22	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.87442531
23	FOXP3_21729870_ChIP-Seq_TREG_Human	1.84831139
24	GBX2_23144817_ChIP-Seq_PC3_Human	1.77267320
25	EWS_26573619_Chip-Seq_HEK293_Human	1.74308434
26	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.71512114
27	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.71064482
28	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.69825124
29	TP53_22573176_ChIP-Seq_HFKS_Human	1.69044687
30	MYC_18940864_ChIP-ChIP_HL60_Human	1.62051411
31	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.51929034
32	FUS_26573619_Chip-Seq_HEK293_Human	1.51467050
33	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.51440711
34	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.49102144
35	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.49102144
36	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.48510913
37	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.46473359
38	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.45699334
39	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.44456345
40	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.41778342
41	SOX2_19829295_ChIP-Seq_ESCs_Human	1.41085206
42	NANOG_19829295_ChIP-Seq_ESCs_Human	1.41085206
43	HTT_18923047_ChIP-ChIP_STHdh_Human	1.40741732
44	P300_19829295_ChIP-Seq_ESCs_Human	1.39681040
45	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.38642820
46	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.38634559
47	TAF15_26573619_Chip-Seq_HEK293_Human	1.37271562
48	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.37156485
49	BCAT_22108803_ChIP-Seq_LS180_Human	1.34210255
50	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.32982739
51	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.28633762
52	AR_20517297_ChIP-Seq_VCAP_Human	1.28228321
53	DCP1A_22483619_ChIP-Seq_HELA_Human	1.27084159
54	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.26194212
55	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.23160040
56	GABP_19822575_ChIP-Seq_HepG2_Human	1.20119394
57	ER_23166858_ChIP-Seq_MCF-7_Human	1.19568890
58	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.18196791
59	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.15417669
60	ERG_20517297_ChIP-Seq_VCAP_Human	1.14942610
61	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.14884238
62	NCOR_22424771_ChIP-Seq_293T_Human	1.14438166
63	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.13603127
64	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.13541072
65	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.12527268
66	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.12420736
67	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.11935428
68	CBP_20019798_ChIP-Seq_JUKART_Human	1.11438784
69	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.11438784
70	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.10658584
71	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.09294956
72	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.08311829
73	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.07150218
74	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.05602965
75	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.04599989
76	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.04177459
77	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.02325915
78	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.02210196
79	TAF2_19829295_ChIP-Seq_ESCs_Human	1.01216639
80	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.00452266
81	MYC_19829295_ChIP-Seq_ESCs_Human	0.99967188
82	TCF4_22108803_ChIP-Seq_LS180_Human	0.99960594
83	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	0.99515298
84	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.98366425
85	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.97293736
86	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.96124935
87	NANOG_20526341_ChIP-Seq_ESCs_Human	0.96100431
88	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.96082053
89	GATA3_26560356_Chip-Seq_TH2_Human	0.94590092
90	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.94181206
91	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.93903528
92	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.93032831
93	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.92787897
94	TTF2_22483619_ChIP-Seq_HELA_Human	0.90961524
95	AR_25329375_ChIP-Seq_VCAP_Human	0.89468553
96	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.88262058
97	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.87260284
98	IRF1_19129219_ChIP-ChIP_H3396_Human	0.86761223
99	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.86629209
100	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.86127086

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002837_dystrophic_cardiac_calcinosis	4.23433599
2	MP0008877_abnormal_DNA_methylation	2.73121762
3	MP0003195_calcinosis	2.72702269
4	MP0003806_abnormal_nucleotide_metabolis	2.70404265
5	MP0002139_abnormal_hepatobiliary_system	2.49093344
6	MP0003186_abnormal_redox_activity	2.42101585
7	MP0006072_abnormal_retinal_apoptosis	2.36647369
8	MP0005379_endocrine/exocrine_gland_phen	2.33435970
9	MP0002163_abnormal_gland_morphology	2.26163031
10	MP0008875_abnormal_xenobiotic_pharmacok	2.24348003
11	MP0005084_abnormal_gallbladder_morpholo	2.06784208
12	MP0008058_abnormal_DNA_repair	2.05689604
13	MP0005645_abnormal_hypothalamus_physiol	2.02719782
14	MP0010386_abnormal_urinary_bladder	2.02352716
15	MP0000372_irregular_coat_pigmentation	2.00108768
16	MP0002876_abnormal_thyroid_physiology	1.95472095
17	MP0006036_abnormal_mitochondrial_physio	1.92014400
18	MP0005551_abnormal_eye_electrophysiolog	1.91339278
19	MP0001764_abnormal_homeostasis	1.87908348
20	MP0009046_muscle_twitch	1.82721959
21	MP0005174_abnormal_tail_pigmentation	1.71956613
22	MP0003252_abnormal_bile_duct	1.70472231
23	MP0001968_abnormal_touch/_nociception	1.70469254
24	MP0003011_delayed_dark_adaptation	1.69755151
25	MP0008872_abnormal_physiological_respon	1.59544316
26	MP0002736_abnormal_nociception_after	1.58788028
27	MP0001984_abnormal_olfaction	1.57699453
28	MP0002638_abnormal_pupillary_reflex	1.57408666
29	MP0005075_abnormal_melanosome_morpholog	1.57405488
30	MP0005646_abnormal_pituitary_gland	1.57327816
31	MP0003880_abnormal_central_pattern	1.54390622
32	MP0009697_abnormal_copulation	1.54276850
33	MP0006054_spinal_hemorrhage	1.53270348
34	MP0002138_abnormal_hepatobiliary_system	1.50141288
35	MP0003718_maternal_effect	1.49595566
36	MP0001905_abnormal_dopamine_level	1.49003562
37	MP0006292_abnormal_olfactory_placode	1.48201610
38	MP0005410_abnormal_fertilization	1.45081481
39	MP0002693_abnormal_pancreas_physiology	1.43973126
40	MP0005332_abnormal_amino_acid	1.43667896
41	MP0005253_abnormal_eye_physiology	1.42124869
42	MP0005636_abnormal_mineral_homeostasis	1.37124338
43	MP0002653_abnormal_ependyma_morphology	1.35326413
44	MP0009785_altered_susceptibility_to	1.34478952
45	MP0003787_abnormal_imprinting	1.33731466
46	MP0006035_abnormal_mitochondrial_morpho	1.32951774
47	MP0004147_increased_porphyrin_level	1.31568780
48	MP0002102_abnormal_ear_morphology	1.30173234
49	MP0003786_premature_aging	1.29478042
50	MP0005671_abnormal_response_to	1.26910080
51	MP0001501_abnormal_sleep_pattern	1.24162019
52	MP0002272_abnormal_nervous_system	1.21867242
53	MP0002160_abnormal_reproductive_system	1.21444062
54	MP0002909_abnormal_adrenal_gland	1.14757048
55	MP0004142_abnormal_muscle_tone	1.13768122
56	MP0004145_abnormal_muscle_electrophysio	1.13739298
57	MP0005389_reproductive_system_phenotype	1.12815085
58	MP0006082_CNS_inflammation	1.12591274
59	MP0005365_abnormal_bile_salt	1.12233988
60	MP0004019_abnormal_vitamin_homeostasis	1.12116639
61	MP0002938_white_spotting	1.11743441
62	MP0004215_abnormal_myocardial_fiber	1.11668488
63	MP0002148_abnormal_hypersensitivity_rea	1.11337984
64	MP0005220_abnormal_exocrine_pancreas	1.08690114
65	MP0002277_abnormal_respiratory_mucosa	1.07327878
66	MP0010329_abnormal_lipoprotein_level	1.07292137
67	MP0009745_abnormal_behavioral_response	1.05453472
68	MP0001944_abnormal_pancreas_morphology	1.05376464
69	MP0005085_abnormal_gallbladder_physiolo	1.04662566
70	MP0002095_abnormal_skin_pigmentation	1.04176788
71	MP0000015_abnormal_ear_pigmentation	1.01306922
72	MP0004885_abnormal_endolymph	1.01214677
73	MP0001986_abnormal_taste_sensitivity	0.98866303
74	MP0005319_abnormal_enzyme/_coenzyme	0.96641529
75	MP0003646_muscle_fatigue	0.96564493
76	MP0001756_abnormal_urination	0.93325102
77	MP0002229_neurodegeneration	0.92654906
78	MP0002254_reproductive_system_inflammat	0.92481978
79	MP0001929_abnormal_gametogenesis	0.92307211
80	MP0005266_abnormal_metabolism	0.92175312
81	MP0005535_abnormal_body_temperature	0.91706122
82	MP0002090_abnormal_vision	0.86452346
83	MP0006276_abnormal_autonomic_nervous	0.82174912
84	MP0005360_urolithiasis	0.81927386
85	MP0009643_abnormal_urine_homeostasis	0.80257622
86	MP0000639_abnormal_adrenal_gland	0.78779542
87	MP0001485_abnormal_pinna_reflex	0.78749164
88	MP0001970_abnormal_pain_threshold	0.77716666
89	MP0009379_abnormal_foot_pigmentation	0.77253261
90	MP0002078_abnormal_glucose_homeostasis	0.75671538
91	MP0002210_abnormal_sex_determination	0.74747836
92	MP0002735_abnormal_chemical_nociception	0.74731050
93	MP0008873_increased_physiological_sensi	0.74617254
94	MP0001529_abnormal_vocalization	0.74360447
95	MP0005367_renal/urinary_system_phenotyp	0.73633497
96	MP0000516_abnormal_urinary_system	0.73633497
97	MP0000653_abnormal_sex_gland	0.72396061
98	MP0008469_abnormal_protein_level	0.71547542
99	MP0004133_heterotaxia	0.69987632
100	MP0009764_decreased_sensitivity_to	0.69746387

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.73600399
2	Mitochondrial inheritance (HP:0001427)	4.50202723
3	Abnormal mitochondria in muscle tissue (HP:0008316)	4.29984144
4	Hepatocellular necrosis (HP:0001404)	4.20261736
5	Progressive macrocephaly (HP:0004481)	4.16280983
6	Acute encephalopathy (HP:0006846)	4.14973780
7	Increased CSF lactate (HP:0002490)	4.14177658
8	Hepatic necrosis (HP:0002605)	4.01425397
9	Increased hepatocellular lipid droplets (HP:0006565)	3.52889002
10	Lipid accumulation in hepatocytes (HP:0006561)	3.52445930
11	Cerebral edema (HP:0002181)	3.30406105
12	Type I transferrin isoform profile (HP:0003642)	3.29273110
13	Renal Fanconi syndrome (HP:0001994)	3.14040767
14	3-Methylglutaconic aciduria (HP:0003535)	3.13266792
15	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.00751544
16	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.00751544
17	Methylmalonic acidemia (HP:0002912)	2.87831034
18	Lactic acidosis (HP:0003128)	2.83097386
19	Pancreatic cysts (HP:0001737)	2.80923896
20	Respiratory failure (HP:0002878)	2.80288841
21	Increased serum lactate (HP:0002151)	2.74516407
22	Abnormal protein glycosylation (HP:0012346)	2.73037545
23	Abnormal glycosylation (HP:0012345)	2.73037545
24	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.73037545
25	Abnormal protein N-linked glycosylation (HP:0012347)	2.73037545
26	Increased intramyocellular lipid droplets (HP:0012240)	2.66121725
27	Abnormality of aromatic amino acid family metabolism (HP:0004338)	2.58480406
28	Glycosuria (HP:0003076)	2.57287472
29	Abnormality of urine glucose concentration (HP:0011016)	2.57287472
30	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.56542195
31	Optic disc pallor (HP:0000543)	2.54019968
32	Abnormality of midbrain morphology (HP:0002418)	2.49354638
33	Molar tooth sign on MRI (HP:0002419)	2.49354638
34	Methylmalonic aciduria (HP:0012120)	2.48256004
35	Pancreatic fibrosis (HP:0100732)	2.45817756
36	Lethargy (HP:0001254)	2.45210339
37	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.40315001
38	Reduced antithrombin III activity (HP:0001976)	2.37225664
39	CNS demyelination (HP:0007305)	2.37092663
40	Abnormality of the renal cortex (HP:0011035)	2.36356855
41	Ketoacidosis (HP:0001993)	2.36242921
42	Increased muscle lipid content (HP:0009058)	2.35713304
43	Nephronophthisis (HP:0000090)	2.34961116
44	Renal cortical cysts (HP:0000803)	2.30287378
45	Exertional dyspnea (HP:0002875)	2.29917783
46	True hermaphroditism (HP:0010459)	2.28037708
47	Abolished electroretinogram (ERG) (HP:0000550)	2.26293039
48	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.26073804
49	Dicarboxylic aciduria (HP:0003215)	2.26073804
50	Generalized aminoaciduria (HP:0002909)	2.25318156
51	Ketosis (HP:0001946)	2.25263845
52	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.25061552
53	Medial flaring of the eyebrow (HP:0010747)	2.24149572
54	Abnormality of renal resorption (HP:0011038)	2.23581477
55	Congenital stationary night blindness (HP:0007642)	2.23445140
56	Abnormal rod and cone electroretinograms (HP:0008323)	2.21782306
57	Hypoglycemic coma (HP:0001325)	2.19667780
58	Hypothermia (HP:0002045)	2.15531606
59	Exercise intolerance (HP:0003546)	2.12738316
60	Aplastic anemia (HP:0001915)	2.11372054
61	Abnormality of vitamin B metabolism (HP:0004340)	2.10847283
62	Stomatitis (HP:0010280)	2.08189043
63	Attenuation of retinal blood vessels (HP:0007843)	2.02428321
64	Leukodystrophy (HP:0002415)	2.01937518
65	Hypoproteinemia (HP:0003075)	2.01810781
66	Opisthotonus (HP:0002179)	2.01379332
67	Constricted visual fields (HP:0001133)	1.99845780
68	Hypoglycemic seizures (HP:0002173)	1.98542590
69	Large for gestational age (HP:0001520)	1.98310606
70	Abnormality of the renal medulla (HP:0100957)	1.96301068
71	Hyperinsulinemic hypoglycemia (HP:0000825)	1.94776762
72	Polydipsia (HP:0001959)	1.89018784
73	Abnormal drinking behavior (HP:0030082)	1.89018784
74	Hyperglycinemia (HP:0002154)	1.88497599
75	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.86717496
76	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.84538106
77	Abnormality of alanine metabolism (HP:0010916)	1.84538106
78	Hyperalaninemia (HP:0003348)	1.84538106
79	Hypomagnesemia (HP:0002917)	1.84016376
80	Degeneration of anterior horn cells (HP:0002398)	1.83401725
81	Abnormality of the anterior horn cell (HP:0006802)	1.83401725
82	Oral leukoplakia (HP:0002745)	1.80599888
83	Hyperphosphaturia (HP:0003109)	1.79663738
84	Respiratory difficulties (HP:0002880)	1.77801726
85	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.76514638
86	Aplasia/hypoplasia of the uterus (HP:0008684)	1.72648885
87	Bile duct proliferation (HP:0001408)	1.71234145
88	Abnormal biliary tract physiology (HP:0012439)	1.71234145
89	Progressive neurologic deterioration (HP:0002344)	1.71141716
90	Palpitations (HP:0001962)	1.69696873
91	Hyperglycemia (HP:0003074)	1.69319750
92	Emotional lability (HP:0000712)	1.68339702
93	Progressive microcephaly (HP:0000253)	1.67933362
94	Pancytopenia (HP:0001876)	1.67397013
95	Abnormality of the pons (HP:0007361)	1.66027108
96	Thyroiditis (HP:0100646)	1.65744509
97	Hypoplasia of the pons (HP:0012110)	1.65738917
98	Congenital sensorineural hearing impairment (HP:0008527)	1.63836454
99	Hypoplasia of the fovea (HP:0007750)	1.63671389
100	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.63671389

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	VRK2	3.62864034
2	MAP4K2	3.33852148
3	FRK	3.23728314
4	BCKDK	2.92204939
5	MST4	2.61450581
6	ADRBK2	2.37885873
7	ZAK	2.28908666
8	NUAK1	2.02703357
9	TXK	1.87469053
10	MAP3K12	1.86024497
11	WNK3	1.82942440
12	BMPR1B	1.81156637
13	VRK1	1.75905451
14	EIF2AK3	1.73362622
15	GRK1	1.73161817
16	ACVR1B	1.72226817
17	PASK	1.66931733
18	TRIM28	1.62893228
19	KDR	1.61249219
20	STK16	1.60324552
21	NME2	1.54999190
22	INSRR	1.48017985
23	OXSR1	1.45759461
24	TLK1	1.39595358
25	BUB1	1.26814748
26	WNK4	1.23261521
27	PINK1	1.20431752
28	PHKG2	1.20350747
29	PHKG1	1.20350747
30	CSNK1G3	1.19636575
31	STK39	1.16983495
32	MAP2K6	1.15726565
33	CSNK1G1	1.14246966
34	ARAF	1.09605176
35	CSNK1G2	1.03853400
36	DAPK1	1.02361220
37	EIF2AK1	1.00592998
38	PIM2	1.00353486
39	PRKCE	0.98395757
40	KIT	0.97144658
41	MUSK	0.95539628
42	PLK2	0.93683979
43	TEC	0.92202257
44	PLK3	0.89249915
45	DAPK2	0.88480736
46	TAOK3	0.87181417
47	TNIK	0.85695194
48	PLK4	0.84976362
49	ADRBK1	0.84147644
50	CDK19	0.82470361
51	MYLK	0.81722233
52	DYRK2	0.81331126
53	ITK	0.79056483
54	IKBKB	0.78952032
55	PAK3	0.78294629
56	PDK2	0.77970399
57	MAPK13	0.77421542
58	ABL2	0.74303152
59	BRSK2	0.72966959
60	CSNK1A1L	0.72909412
61	SYK	0.72830011
62	PRKCQ	0.70979358
63	LIMK1	0.70338034
64	NME1	0.69971597
65	MAP3K4	0.69619341
66	TAF1	0.68004398
67	PRKCG	0.67730974
68	GRK5	0.67021851
69	PBK	0.60368136
70	GRK7	0.57960950
71	TNK2	0.56331577
72	CAMKK2	0.53617148
73	RPS6KA5	0.53160577
74	MAPKAPK5	0.51530368
75	CAMK2D	0.50578328
76	IKBKE	0.48635180
77	TRPM7	0.47769474
78	NEK1	0.46975527
79	PLK1	0.46958943
80	OBSCN	0.46366359
81	MAP4K1	0.45352311
82	CSNK1A1	0.44974772
83	TESK1	0.44325118
84	SCYL2	0.44091464
85	CSNK2A1	0.44053192
86	PRKCA	0.43445235
87	ERBB3	0.42683336
88	TESK2	0.42666272
89	PRKACA	0.42539683
90	PRKG1	0.41668255
91	PRKCI	0.40874920
92	TIE1	0.38465067
93	PTK2B	0.38080524
94	LYN	0.37486886
95	NLK	0.37313811
96	DAPK3	0.37084335
97	EIF2AK2	0.36523929
98	CSNK2A2	0.35817685
99	CAMK2A	0.35522272
100	JAK3	0.35292224

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	4.09010597
2	Proteasome_Homo sapiens_hsa03050	3.36793142
3	Parkinsons disease_Homo sapiens_hsa05012	3.22552330
4	Protein export_Homo sapiens_hsa03060	3.03676175
5	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.42106117
6	RNA polymerase_Homo sapiens_hsa03020	2.17108921
7	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.16583471
8	Fatty acid elongation_Homo sapiens_hsa00062	2.12307208
9	Huntingtons disease_Homo sapiens_hsa05016	2.10525623
10	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.06329326
11	Alzheimers disease_Homo sapiens_hsa05010	2.05520173
12	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.99076368
13	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.84972367
14	Sulfur metabolism_Homo sapiens_hsa00920	1.82991838
15	Ribosome_Homo sapiens_hsa03010	1.70293210
16	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.64027875
17	Butanoate metabolism_Homo sapiens_hsa00650	1.63041425
18	Folate biosynthesis_Homo sapiens_hsa00790	1.56876474
19	Homologous recombination_Homo sapiens_hsa03440	1.55544870
20	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.50577621
21	Collecting duct acid secretion_Homo sapiens_hsa04966	1.48163616
22	Peroxisome_Homo sapiens_hsa04146	1.48013700
23	Type I diabetes mellitus_Homo sapiens_hsa04940	1.42733488
24	Propanoate metabolism_Homo sapiens_hsa00640	1.36650946
25	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.36424958
26	Mismatch repair_Homo sapiens_hsa03430	1.32521515
27	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.27209769
28	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.26826573
29	Pyrimidine metabolism_Homo sapiens_hsa00240	1.26010705
30	Asthma_Homo sapiens_hsa05310	1.24814189
31	Glutathione metabolism_Homo sapiens_hsa00480	1.22863235
32	Cardiac muscle contraction_Homo sapiens_hsa04260	1.22777168
33	Phototransduction_Homo sapiens_hsa04744	1.21606311
34	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.20961126
35	Rheumatoid arthritis_Homo sapiens_hsa05323	1.19518606
36	Tryptophan metabolism_Homo sapiens_hsa00380	1.13258580
37	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.10332643
38	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.10003333
39	Regulation of autophagy_Homo sapiens_hsa04140	1.08606925
40	Purine metabolism_Homo sapiens_hsa00230	1.07270738
41	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.06628877
42	Basal transcription factors_Homo sapiens_hsa03022	1.06382377
43	Chemical carcinogenesis_Homo sapiens_hsa05204	1.04427879
44	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.03870400
45	Fanconi anemia pathway_Homo sapiens_hsa03460	1.01328246
46	Primary immunodeficiency_Homo sapiens_hsa05340	1.01267322
47	DNA replication_Homo sapiens_hsa03030	1.00695701
48	Base excision repair_Homo sapiens_hsa03410	0.99777674
49	RNA degradation_Homo sapiens_hsa03018	0.97107043
50	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.96425216
51	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.95904125
52	Non-homologous end-joining_Homo sapiens_hsa03450	0.92015941
53	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.90812266
54	Metabolic pathways_Homo sapiens_hsa01100	0.89359298
55	Nucleotide excision repair_Homo sapiens_hsa03420	0.85110728
56	Allograft rejection_Homo sapiens_hsa05330	0.85023715
57	Retinol metabolism_Homo sapiens_hsa00830	0.83236342
58	Fatty acid degradation_Homo sapiens_hsa00071	0.83048683
59	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.82367761
60	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.79153442
61	beta-Alanine metabolism_Homo sapiens_hsa00410	0.79130616
62	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.78804510
63	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.78385385
64	Nitrogen metabolism_Homo sapiens_hsa00910	0.77535693
65	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.75862099
66	Selenocompound metabolism_Homo sapiens_hsa00450	0.73972113
67	Linoleic acid metabolism_Homo sapiens_hsa00591	0.71721850
68	Fatty acid metabolism_Homo sapiens_hsa01212	0.70697607
69	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.68735322
70	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.67891672
71	Pyruvate metabolism_Homo sapiens_hsa00620	0.66688448
72	One carbon pool by folate_Homo sapiens_hsa00670	0.66447183
73	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.66235272
74	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.65034367
75	Mineral absorption_Homo sapiens_hsa04978	0.62020969
76	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.61817108
77	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.60515895
78	Caffeine metabolism_Homo sapiens_hsa00232	0.60278698
79	Graft-versus-host disease_Homo sapiens_hsa05332	0.59995286
80	Ether lipid metabolism_Homo sapiens_hsa00565	0.59789753
81	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.56952665
82	Tyrosine metabolism_Homo sapiens_hsa00350	0.56892810
83	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.55827169
84	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.51250103
85	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.51242534
86	Sulfur relay system_Homo sapiens_hsa04122	0.49734612
87	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.48628824
88	Vibrio cholerae infection_Homo sapiens_hsa05110	0.47116477
89	Insulin secretion_Homo sapiens_hsa04911	0.46450537
90	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.45154062
91	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.39174971
92	Steroid biosynthesis_Homo sapiens_hsa00100	0.38430121
93	Lysosome_Homo sapiens_hsa04142	0.36994393
94	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.36451288
95	Olfactory transduction_Homo sapiens_hsa04740	0.35819328
96	RNA transport_Homo sapiens_hsa03013	0.34389781
97	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.33210100
98	Spliceosome_Homo sapiens_hsa03040	0.32198507
99	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.31625135
100	Fat digestion and absorption_Homo sapiens_hsa04975	0.30318243

TECRP1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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