TECRP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytidine metabolic process (GO:0046087)6.41616305
2cytidine catabolic process (GO:0006216)6.41616305
3cytidine deamination (GO:0009972)6.41616305
4negative regulation by host of viral transcription (GO:0043922)5.59758741
5ovulation cycle (GO:0042698)5.54952138
6regulation of chronic inflammatory response (GO:0002676)5.43245238
7DNA deamination (GO:0045006)5.19921151
8pyrimidine ribonucleoside catabolic process (GO:0046133)5.19729683
9regulation of activation of Janus kinase activity (GO:0010533)5.00938972
10eosinophil chemotaxis (GO:0048245)4.95914221
11regulation of memory T cell differentiation (GO:0043380)4.90290539
12interferon-gamma secretion (GO:0072643)4.88546262
13positive regulation of defense response to virus by host (GO:0002230)4.81789077
14regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.60127107
15positive regulation of T cell apoptotic process (GO:0070234)4.58075163
16eosinophil migration (GO:0072677)4.41448449
17macrophage chemotaxis (GO:0048246)4.33467756
18regulation of mononuclear cell migration (GO:0071675)4.19122825
19regulation of lymphocyte chemotaxis (GO:1901623)4.14710219
20amyloid precursor protein catabolic process (GO:0042987)4.12883829
21negative regulation of membrane potential (GO:0045837)4.08513628
22negative regulation of synaptic transmission, glutamatergic (GO:0051967)4.03870131
23regulation of T cell chemotaxis (GO:0010819)3.97778751
24positive regulation of T cell chemotaxis (GO:0010820)3.97778751
25positive regulation of lymphocyte apoptotic process (GO:0070230)3.94860782
26positive regulation of catecholamine secretion (GO:0033605)3.90899351
27signal peptide processing (GO:0006465)3.86841031
28activated T cell proliferation (GO:0050798)3.81226662
29negative regulation of T cell apoptotic process (GO:0070233)3.70937289
30positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.63199259
31regulation of tight junction assembly (GO:2000810)3.60834431
32sulfation (GO:0051923)3.59269320
33mitochondrial respiratory chain complex I assembly (GO:0032981)3.55221047
34NADH dehydrogenase complex assembly (GO:0010257)3.55221047
35mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.55221047
36regulation of chemokine-mediated signaling pathway (GO:0070099)3.52949087
37negative regulation of lymphocyte apoptotic process (GO:0070229)3.44393892
38regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 3.42012518
39positive regulation of interleukin-8 secretion (GO:2000484)3.39824705
40regulation of defense response to virus by host (GO:0050691)3.35861908
41positive regulation of granulocyte differentiation (GO:0030854)3.31917404
42DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.29300229
43regulation of double-strand break repair via homologous recombination (GO:0010569)3.28041193
44modulation of transcription in other organism involved in symbiotic interaction (GO:0052312)3.26444302
45regulation of macrophage chemotaxis (GO:0010758)3.25394676
46negative regulation of mast cell activation (GO:0033004)3.24290768
47negative regulation of viral transcription (GO:0032897)3.20609115
48positive regulation of calcium-mediated signaling (GO:0050850)3.18873558
49water-soluble vitamin biosynthetic process (GO:0042364)3.18700901
50DNA demethylation (GO:0080111)3.17437964
51C21-steroid hormone biosynthetic process (GO:0006700)3.16462724
52mismatch repair (GO:0006298)3.14706733
53modulation by host of symbiont transcription (GO:0052472)3.14550587
54modulation by host of viral transcription (GO:0043921)3.14550587
55regulation of feeding behavior (GO:0060259)3.12055915
56T cell mediated immunity (GO:0002456)3.11694056
57mesenchymal cell differentiation involved in kidney development (GO:0072161)3.11139132
58mesenchymal cell differentiation involved in renal system development (GO:2001012)3.11139132
59pyrimidine nucleoside catabolic process (GO:0046135)3.08810692
60regulation of superoxide anion generation (GO:0032928)3.07957782
61negative regulation of viral genome replication (GO:0045071)3.07050096
62auditory behavior (GO:0031223)3.05748477
63positive regulation of monocyte chemotaxis (GO:0090026)3.03206926
64regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.98739631
65negative regulation of T-helper cell differentiation (GO:0045623)2.98169626
66negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.98169626
67response to xenobiotic stimulus (GO:0009410)2.98037602
68DNA damage response, signal transduction resulting in transcription (GO:0042772)2.95230742
69postsynaptic membrane organization (GO:0001941)2.94097371
70regulation of phospholipase A2 activity (GO:0032429)2.92706172
71negative regulation of T cell differentiation in thymus (GO:0033085)2.92234531
72amyloid precursor protein metabolic process (GO:0042982)2.91588067
73cellular potassium ion homeostasis (GO:0030007)2.91320024
74mesonephros development (GO:0001823)2.91075082
75negative regulation of neurological system process (GO:0031645)2.89947241
76protein complex biogenesis (GO:0070271)2.89720657
77membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.88812193
78positive regulation of lymphocyte migration (GO:2000403)2.88191320
79glycine transport (GO:0015816)2.82476692
80cardiac left ventricle morphogenesis (GO:0003214)2.82215402
81regulation of skeletal muscle contraction (GO:0014819)2.82175067
82regulation of T cell apoptotic process (GO:0070232)2.77693710
83oxidative demethylation (GO:0070989)2.74457136
84regulation of immunoglobulin secretion (GO:0051023)2.71779492
85cellular response to exogenous dsRNA (GO:0071360)2.69570842
86positive regulation of tolerance induction (GO:0002645)2.69219330
87DNA dealkylation (GO:0035510)2.67942658
88histone H3-K9 methylation (GO:0051567)2.67013520
89proteasome assembly (GO:0043248)2.66628419
90granulocyte activation (GO:0036230)2.63807719
91regulation of calcium-mediated signaling (GO:0050848)2.62516496
92regulation of lymphocyte apoptotic process (GO:0070228)2.61108832
93cellular response to interleukin-15 (GO:0071350)2.61040399
94tongue development (GO:0043586)2.58295134
95positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.57330222
96fatty acid elongation (GO:0030497)2.57083120
97regulation of germinal center formation (GO:0002634)2.56239119
98positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)2.55869258
99negative regulation of B cell apoptotic process (GO:0002903)2.55692346
100cytokine biosynthetic process (GO:0042089)2.54711779

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.89127212
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.69597714
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.68862323
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human4.20877250
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.40174415
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.33126867
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.26298081
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.98950535
9TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.96086967
10ZNF274_21170338_ChIP-Seq_K562_Hela2.82157827
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.65719050
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.42254250
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.23951056
14IRF8_22096565_ChIP-ChIP_GC-B_Human2.19040895
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.16323610
16NOTCH1_21737748_ChIP-Seq_TLL_Human2.15197311
17GATA1_22025678_ChIP-Seq_K562_Human2.07450646
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.06541546
19CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.82360950
20ZFP57_27257070_Chip-Seq_ESCs_Mouse1.80791939
21VDR_23849224_ChIP-Seq_CD4+_Human1.77896528
22IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.75164822
23SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.71346514
24ELK1_19687146_ChIP-ChIP_HELA_Human1.69923774
25ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.67232674
26SMAD_19615063_ChIP-ChIP_OVARY_Human1.66635589
27RUNX_20019798_ChIP-Seq_JUKART_Human1.62470347
28ELK1_22589737_ChIP-Seq_MCF10A_Human1.59646979
29SRF_21415370_ChIP-Seq_HL-1_Mouse1.58034497
30YY1_21170310_ChIP-Seq_MESCs_Mouse1.58013750
31PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.54666818
32JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.52640474
33HIF1A_21447827_ChIP-Seq_MCF-7_Human1.50175234
34FOXH1_21741376_ChIP-Seq_EPCs_Human1.46890819
35ETS1_20019798_ChIP-Seq_JURKAT_Human1.46067589
36FOXP3_21729870_ChIP-Seq_TREG_Human1.44159028
37JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.44008682
38GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42576348
39GBX2_23144817_ChIP-Seq_PC3_Human1.40642133
40MYB_26560356_Chip-Seq_TH2_Human1.36353921
41P300_19829295_ChIP-Seq_ESCs_Human1.29139616
42JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.27257867
43EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.27028241
44CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.22327103
45BCAT_22108803_ChIP-Seq_LS180_Human1.21306450
46GATA3_26560356_Chip-Seq_TH2_Human1.20863373
47TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.18964671
48PADI4_21655091_ChIP-ChIP_MCF-7_Human1.18367841
49STAT4_19710469_ChIP-ChIP_TH1__Mouse1.18221125
50CIITA_25753668_ChIP-Seq_RAJI_Human1.16359600
51PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.13937786
52CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.13706506
53IRF8_21731497_ChIP-ChIP_J774_Mouse1.13118134
54RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.12517262
55TP53_22573176_ChIP-Seq_HFKS_Human1.11369915
56POU5F1_16153702_ChIP-ChIP_HESCs_Human1.09792537
57SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.09044050
58MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.04665510
59MYC_18940864_ChIP-ChIP_HL60_Human1.04416732
60VDR_22108803_ChIP-Seq_LS180_Human1.03721219
61CREB1_15753290_ChIP-ChIP_HEK293T_Human1.03493316
62GATA3_27048872_Chip-Seq_THYMUS_Human1.01292894
63PRDM14_20953172_ChIP-Seq_ESCs_Human1.01228398
64GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.99917994
65CTBP2_25329375_ChIP-Seq_LNCAP_Human0.99411566
66GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.98586327
67AR_21572438_ChIP-Seq_LNCaP_Human0.97597058
68LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.96026056
69ERG_20517297_ChIP-Seq_VCAP_Human0.95952898
70EWS_26573619_Chip-Seq_HEK293_Human0.94759138
71FOXA1_21572438_ChIP-Seq_LNCaP_Human0.93700382
72FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.93145462
73ER_23166858_ChIP-Seq_MCF-7_Human0.92974016
74PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91251849
75GATA1_26923725_Chip-Seq_HPCs_Mouse0.91084066
76CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.90631413
77PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.90297847
78TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.90139421
79EGR1_23403033_ChIP-Seq_LIVER_Mouse0.89848082
80CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.89464719
81FUS_26573619_Chip-Seq_HEK293_Human0.88306486
82EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.87965931
83GATA3_21878914_ChIP-Seq_MCF-7_Human0.86472650
84BMI1_23680149_ChIP-Seq_NPCS_Mouse0.86331847
85HOXB7_26014856_ChIP-Seq_BT474_Human0.86162628
86UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.86022025
87EED_16625203_ChIP-ChIP_MESCs_Mouse0.85963250
88ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.85894881
89FOXA1_27270436_Chip-Seq_PROSTATE_Human0.85500471
90FOXA1_25329375_ChIP-Seq_VCAP_Human0.85500471
91GATA3_26560356_Chip-Seq_TH1_Human0.85010357
92SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.84993799
93TCF4_22108803_ChIP-Seq_LS180_Human0.84857054
94BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.84471499
95SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.83724125
96LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.83639566
97EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.83260231
98TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.82497661
99CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.82272491
100FOXH1_21741376_ChIP-Seq_ESCs_Human0.82227109

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.00246220
2MP0005423_abnormal_somatic_nervous3.35617915
3MP0006072_abnormal_retinal_apoptosis3.16573966
4MP0005671_abnormal_response_to3.10128545
5MP0000685_abnormal_immune_system2.77513546
6MP0003880_abnormal_central_pattern2.62241496
7MP0006082_CNS_inflammation2.45769736
8MP0008775_abnormal_heart_ventricle2.44768750
9MP0001501_abnormal_sleep_pattern2.42321538
10MP0001348_abnormal_lacrimal_gland2.27755556
11MP0000383_abnormal_hair_follicle2.25255939
12MP0001986_abnormal_taste_sensitivity2.11753748
13MP0005253_abnormal_eye_physiology2.09872886
14MP0004142_abnormal_muscle_tone2.02767148
15MP0001968_abnormal_touch/_nociception1.90962902
16MP0003763_abnormal_thymus_physiology1.88928387
17MP0005387_immune_system_phenotype1.88646258
18MP0001790_abnormal_immune_system1.88646258
19MP0010368_abnormal_lymphatic_system1.83510692
20MP0008877_abnormal_DNA_methylation1.82528860
21MP0002148_abnormal_hypersensitivity_rea1.81543338
22MP0009745_abnormal_behavioral_response1.77343407
23MP0003786_premature_aging1.67002230
24MP0000613_abnormal_salivary_gland1.65401015
25MP0009046_muscle_twitch1.65247536
26MP0006054_spinal_hemorrhage1.65136124
27MP0002138_abnormal_hepatobiliary_system1.61039267
28MP0002736_abnormal_nociception_after1.59519776
29MP0001502_abnormal_circadian_rhythm1.45385107
30MP0002095_abnormal_skin_pigmentation1.43968738
31MP0009333_abnormal_splenocyte_physiolog1.40162419
32MP0008007_abnormal_cellular_replicative1.40093627
33MP0003191_abnormal_cellular_cholesterol1.39862222
34MP0001905_abnormal_dopamine_level1.39218168
35MP0009384_cardiac_valve_regurgitation1.39134179
36MP0001853_heart_inflammation1.38436657
37MP0005000_abnormal_immune_tolerance1.37321320
38MP0001919_abnormal_reproductive_system1.36674189
39MP0008872_abnormal_physiological_respon1.30343561
40MP0001873_stomach_inflammation1.29924216
41MP0009765_abnormal_xenobiotic_induced1.29614259
42MP0001835_abnormal_antigen_presentation1.28519021
43MP0003436_decreased_susceptibility_to1.25886444
44MP0005647_abnormal_sex_gland1.24381883
45MP0003195_calcinosis1.24229454
46MP0002723_abnormal_immune_serum1.24228434
47MP0005551_abnormal_eye_electrophysiolog1.21498833
48MP0001800_abnormal_humoral_immune1.21297492
49MP0005389_reproductive_system_phenotype1.20675358
50MP0003718_maternal_effect1.19563541
51MP0005365_abnormal_bile_salt1.17158257
52MP0000465_gastrointestinal_hemorrhage1.15636875
53MP0002064_seizures1.15239572
54MP0002277_abnormal_respiratory_mucosa1.11496846
55MP0001440_abnormal_grooming_behavior1.09875526
56MP0001486_abnormal_startle_reflex1.09704385
57MP0002420_abnormal_adaptive_immunity1.09574379
58MP0002405_respiratory_system_inflammati1.08181299
59MP0002272_abnormal_nervous_system1.07964024
60MP0000427_abnormal_hair_cycle1.07667227
61MP0001819_abnormal_immune_cell1.07510937
62MP0001764_abnormal_homeostasis1.07042103
63MP0000569_abnormal_digit_pigmentation1.04497807
64MP0002332_abnormal_exercise_endurance1.03746640
65MP0002735_abnormal_chemical_nociception1.00618252
66MP0009053_abnormal_anal_canal0.99937625
67MP0006276_abnormal_autonomic_nervous0.94751475
68MP0004885_abnormal_endolymph0.94678055
69MP0010678_abnormal_skin_adnexa0.91546542
70MP0002452_abnormal_antigen_presenting0.90962964
71MP0003635_abnormal_synaptic_transmissio0.89461421
72MP0000716_abnormal_immune_system0.87597778
73MP0002067_abnormal_sensory_capabilities0.87226849
74MP0001765_abnormal_ion_homeostasis0.85517295
75MP0009763_increased_sensitivity_to0.85082134
76MP0002837_dystrophic_cardiac_calcinosis0.84069187
77MP0008058_abnormal_DNA_repair0.83785362
78MP0002163_abnormal_gland_morphology0.83519648
79MP0001881_abnormal_mammary_gland0.83447997
80MP0004924_abnormal_behavior0.83423518
81MP0005386_behavior/neurological_phenoty0.83423518
82MP0005165_increased_susceptibility_to0.80434048
83MP0002006_tumorigenesis0.79558628
84MP0000703_abnormal_thymus_morphology0.79448783
85MP0000579_abnormal_nail_morphology0.78006228
86MP0008569_lethality_at_weaning0.76378274
87MP0003638_abnormal_response/metabolism_0.75260138
88MP0002722_abnormal_immune_system0.74416527
89MP0004215_abnormal_myocardial_fiber0.74280474
90MP0002572_abnormal_emotion/affect_behav0.73744185
91MP0003806_abnormal_nucleotide_metabolis0.73095175
92MP0008875_abnormal_xenobiotic_pharmacok0.72283786
93MP0001984_abnormal_olfaction0.72198746
94MP0002398_abnormal_bone_marrow0.71822670
95MP0001970_abnormal_pain_threshold0.71154221
96MP0005391_vision/eye_phenotype0.70122840
97MP0009780_abnormal_chondrocyte_physiolo0.69898624
98MP0002733_abnormal_thermal_nociception0.68549033
99MP0000689_abnormal_spleen_morphology0.68259795
100MP0002876_abnormal_thyroid_physiology0.68083555

Predicted human phenotypes

RankGene SetZ-score
1Hemiplegia (HP:0002301)5.01319330
2Fibular aplasia (HP:0002990)3.96297060
3Abnormality of the phalanges of the 2nd finger (HP:0009541)3.82475508
4Male infertility (HP:0003251)3.76482827
5Hemiparesis (HP:0001269)3.34206051
6Hepatocellular necrosis (HP:0001404)3.31790491
7Atonic seizures (HP:0010819)3.18793024
8Entropion (HP:0000621)3.12723695
9Oral leukoplakia (HP:0002745)3.04523849
10Squamous cell carcinoma (HP:0002860)2.97788834
11Abnormality of T cell number (HP:0011839)2.97610078
12Tetraplegia (HP:0002445)2.97060093
13T lymphocytopenia (HP:0005403)2.93401966
14IgG deficiency (HP:0004315)2.89612345
15Hepatic necrosis (HP:0002605)2.82633712
16Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.79258342
17Congenital, generalized hypertrichosis (HP:0004540)2.78306429
18Abnormality of the proximal phalanges of the hand (HP:0009834)2.75158511
19Elevated erythrocyte sedimentation rate (HP:0003565)2.73858086
20Cutaneous melanoma (HP:0012056)2.71859220
21Progressive cerebellar ataxia (HP:0002073)2.71698950
22Alveolar cell carcinoma (HP:0006519)2.69151635
23Aplasia/hypoplasia of the uterus (HP:0008684)2.68893987
24Increased CSF lactate (HP:0002490)2.60351896
25Pustule (HP:0200039)2.59830658
26Autoimmune hemolytic anemia (HP:0001890)2.57600124
27Abolished electroretinogram (ERG) (HP:0000550)2.55378061
28Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.54983221
29Adrenal hypoplasia (HP:0000835)2.51419025
30Mitochondrial inheritance (HP:0001427)2.50757822
31Gaze-evoked nystagmus (HP:0000640)2.48111194
32Abnormality of the phalanges of the 5th finger (HP:0004213)2.45823949
33Adactyly (HP:0009776)2.45306182
34Decreased electroretinogram (ERG) amplitude (HP:0000654)2.44288086
35Abnormal delayed hypersensitivity skin test (HP:0002963)2.43433975
36Abnormality of the middle phalanges of the toes (HP:0010183)2.41104714
37Severe muscular hypotonia (HP:0006829)2.39727337
38Abnormality of T cells (HP:0002843)2.39438506
39Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.39167662
40Eosinophilia (HP:0001880)2.38999266
41Pancreatic cysts (HP:0001737)2.38230482
42Hypoproteinemia (HP:0003075)2.35929347
43Neoplasm of the tracheobronchial system (HP:0100552)2.31872758
44Paralysis (HP:0003470)2.30822740
45Hypoplasia of the uterus (HP:0000013)2.28196295
46Status epilepticus (HP:0002133)2.27694190
47Palpitations (HP:0001962)2.25448479
48Conjugated hyperbilirubinemia (HP:0002908)2.21612067
49Reduced subcutaneous adipose tissue (HP:0003758)2.20666503
50Abnormality of DNA repair (HP:0003254)2.19596977
51Action tremor (HP:0002345)2.15610160
52Abnormality of eosinophils (HP:0001879)2.14972894
53Diplopia (HP:0000651)2.14500249
54Abnormality of binocular vision (HP:0011514)2.14500249
55Poikiloderma (HP:0001029)2.12189399
56Conjunctival hamartoma (HP:0100780)2.10498716
57Methylmalonic acidemia (HP:0002912)2.10393488
58Absent speech (HP:0001344)2.09170067
59Rough bone trabeculation (HP:0100670)2.08363607
60Abnormal mitochondria in muscle tissue (HP:0008316)2.06099273
61Focal seizures (HP:0007359)2.04721392
62Acute necrotizing encephalopathy (HP:0006965)2.03842714
63Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.03501761
64Progressive microcephaly (HP:0000253)2.03036545
65Aplasia involving bones of the extremities (HP:0009825)2.02900109
66Aplasia involving bones of the upper limbs (HP:0009823)2.02900109
67Aplasia of the phalanges of the hand (HP:0009802)2.02900109
68Abnormality of the 2nd finger (HP:0004100)2.01564236
69Short femoral neck (HP:0100864)1.97065255
70Ependymoma (HP:0002888)1.96360989
71Aplasia/Hypoplasia of the tibia (HP:0005772)1.95979197
72Pendular nystagmus (HP:0012043)1.92947728
73Degeneration of the lateral corticospinal tracts (HP:0002314)1.91543457
74Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.91543457
75Increased density of long bones (HP:0006392)1.90367293
76Genetic anticipation (HP:0003743)1.85704331
77Bone cyst (HP:0012062)1.85465298
78Abnormality of T cell physiology (HP:0011840)1.84868644
79Verrucae (HP:0200043)1.84772937
80Papilloma (HP:0012740)1.84772937
81Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.84518971
82Granulocytopenia (HP:0001913)1.83723062
83Myoglobinuria (HP:0002913)1.83020244
84Premature graying of hair (HP:0002216)1.82270009
85Hamartoma of the eye (HP:0010568)1.81937985
86True hermaphroditism (HP:0010459)1.81807183
87Optic disc pallor (HP:0000543)1.81550376
88Angiofibromas (HP:0010615)1.81069727
89Adenoma sebaceum (HP:0009720)1.81069727
90Stomatitis (HP:0010280)1.80043847
91Renal cortical cysts (HP:0000803)1.79339875
92Pancreatic fibrosis (HP:0100732)1.79049318
93Dialeptic seizures (HP:0011146)1.78340134
94Melanoma (HP:0002861)1.77103699
95Methylmalonic aciduria (HP:0012120)1.76405352
96Delayed CNS myelination (HP:0002188)1.76029260
97Insulin-resistant diabetes mellitus (HP:0000831)1.71509670
98Gliosis (HP:0002171)1.71194035
99Brushfield spots (HP:0001088)1.70678975
100Congenital stationary night blindness (HP:0007642)1.70226408

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERBB44.05620909
2GRK73.82377585
3DAPK23.43017724
4TESK23.30454846
5FRK3.11799112
6BUB12.86612216
7VRK22.76387757
8TXK2.55321894
9WNK42.34740188
10WNK12.34034384
11TAOK32.08781712
12NUAK11.94609519
13LIMK11.85604815
14KDR1.80293542
15PIK3CA1.70198138
16PHKG11.56302624
17PHKG21.56302624
18FGFR11.56113914
19ITK1.54585799
20PLK21.48608818
21CAMKK21.48590148
22TAF11.46415830
23ADRBK21.38268105
24TESK11.36332893
25PKN11.30369453
26IKBKB1.28356677
27SRPK11.26270309
28CCNB11.25383300
29CSNK1A1L1.25137584
30INSRR1.16615653
31ZAK1.16473597
32GRK51.15847367
33TNIK1.15820883
34NME21.13965254
35CSNK1G31.13055458
36PDK21.12973075
37ADRBK11.10414969
38TNK21.04724825
39MAP2K71.04646335
40SCYL21.03438006
41VRK11.01114630
42CDK30.95685771
43JAK10.95468387
44HIPK20.90216925
45CAMK2G0.89878681
46STK380.89490931
47TTK0.87912408
48PIM20.86241205
49CDK190.86160769
50PRKCE0.85988239
51MAPKAPK30.85176385
52TLK10.83869501
53TRIM280.83472552
54GRK10.82055752
55LCK0.80216837
56NEK90.79718509
57FES0.79525557
58CSNK1G10.79493907
59PRKCQ0.79255926
60CSNK1G20.78746578
61MAP4K10.76333274
62LATS10.76116510
63PTK2B0.76063071
64MAPK110.73466915
65CAMK2A0.72949109
66MAPKAPK50.70974056
67BCKDK0.69468178
68MAP3K110.66661648
69CSNK1D0.66525430
70CSK0.66476294
71SYK0.63353622
72AURKA0.63225026
73ERBB20.61223889
74OXSR10.60577445
75GRK60.59592922
76AKT30.58533776
77PRKCG0.58061856
78BRSK10.56333285
79ATR0.55793602
80TEC0.55337060
81PAK30.54433207
82MAP2K60.52840297
83RPS6KA50.52708257
84IKBKE0.51555015
85TBK10.50831232
86SGK20.50268588
87PRKCH0.48929229
88EPHA20.48459331
89DAPK10.48398042
90NME10.46220359
91PRKCA0.45505525
92SGK2230.42454553
93SGK4940.42454553
94EIF2AK20.40936491
95CSNK2A10.38244530
96STK390.38014072
97CSNK1A10.37685693
98STK40.35830233
99NTRK30.35243491
100PRKACA0.35081087

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.40698683
2Antigen processing and presentation_Homo sapiens_hsa046123.19511926
3Primary immunodeficiency_Homo sapiens_hsa053403.08049787
4Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.69948395
5Cyanoamino acid metabolism_Homo sapiens_hsa004602.68690639
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.44845784
7RNA polymerase_Homo sapiens_hsa030202.38459477
8Graft-versus-host disease_Homo sapiens_hsa053322.33365893
9Oxidative phosphorylation_Homo sapiens_hsa001902.32350249
10Collecting duct acid secretion_Homo sapiens_hsa049662.14041171
11Fatty acid elongation_Homo sapiens_hsa000622.04460735
12Salivary secretion_Homo sapiens_hsa049702.01916798
13Nitrogen metabolism_Homo sapiens_hsa009101.97360688
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.94954709
15Fanconi anemia pathway_Homo sapiens_hsa034601.94399581
16Homologous recombination_Homo sapiens_hsa034401.78407299
17Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.77444072
18SNARE interactions in vesicular transport_Homo sapiens_hsa041301.62971710
19Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.58709888
20Intestinal immune network for IgA production_Homo sapiens_hsa046721.56789494
21Rheumatoid arthritis_Homo sapiens_hsa053231.56114182
22Ether lipid metabolism_Homo sapiens_hsa005651.55943928
23Parkinsons disease_Homo sapiens_hsa050121.55600675
24Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.43966804
25Primary bile acid biosynthesis_Homo sapiens_hsa001201.39152318
26Alzheimers disease_Homo sapiens_hsa050101.37486382
27Autoimmune thyroid disease_Homo sapiens_hsa053201.33595333
28Allograft rejection_Homo sapiens_hsa053301.31623351
29Huntingtons disease_Homo sapiens_hsa050161.23733254
30Linoleic acid metabolism_Homo sapiens_hsa005911.23432340
31Nucleotide excision repair_Homo sapiens_hsa034201.21828699
32Type I diabetes mellitus_Homo sapiens_hsa049401.21586820
33Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.21152243
34Nicotine addiction_Homo sapiens_hsa050331.21127436
35Basal transcription factors_Homo sapiens_hsa030221.20329960
36Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.19658168
37T cell receptor signaling pathway_Homo sapiens_hsa046601.14115858
38One carbon pool by folate_Homo sapiens_hsa006701.05419328
39Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.01348553
40Gastric acid secretion_Homo sapiens_hsa049711.00508093
41Folate biosynthesis_Homo sapiens_hsa007900.98570959
42Peroxisome_Homo sapiens_hsa041460.98378278
43Pentose phosphate pathway_Homo sapiens_hsa000300.97555413
44Taste transduction_Homo sapiens_hsa047420.96819663
45NF-kappa B signaling pathway_Homo sapiens_hsa040640.96396369
46Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.95909090
47Ovarian steroidogenesis_Homo sapiens_hsa049130.95640981
48Insulin secretion_Homo sapiens_hsa049110.95570193
49Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.94947159
50ABC transporters_Homo sapiens_hsa020100.94092469
51Calcium signaling pathway_Homo sapiens_hsa040200.89416311
52Asthma_Homo sapiens_hsa053100.89178742
53Mismatch repair_Homo sapiens_hsa034300.87446726
54Maturity onset diabetes of the young_Homo sapiens_hsa049500.79745911
55Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.79214597
56Morphine addiction_Homo sapiens_hsa050320.76859933
57Propanoate metabolism_Homo sapiens_hsa006400.75659968
58Glutamatergic synapse_Homo sapiens_hsa047240.73425146
59RNA degradation_Homo sapiens_hsa030180.73420861
60alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.72678712
61Cardiac muscle contraction_Homo sapiens_hsa042600.71784263
62Synaptic vesicle cycle_Homo sapiens_hsa047210.68621824
63Measles_Homo sapiens_hsa051620.66336265
64Amphetamine addiction_Homo sapiens_hsa050310.62454345
65Fatty acid biosynthesis_Homo sapiens_hsa000610.61680601
66Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.58606061
67Renin secretion_Homo sapiens_hsa049240.57706592
68Pyrimidine metabolism_Homo sapiens_hsa002400.57422318
69RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.57023188
70Mineral absorption_Homo sapiens_hsa049780.56556438
71Arachidonic acid metabolism_Homo sapiens_hsa005900.54021683
72Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.53426106
73Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.50454194
74Pancreatic secretion_Homo sapiens_hsa049720.49187266
75Hematopoietic cell lineage_Homo sapiens_hsa046400.49158842
76Aldosterone synthesis and secretion_Homo sapiens_hsa049250.49051011
77Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.46103833
78Circadian entrainment_Homo sapiens_hsa047130.45702614
79Olfactory transduction_Homo sapiens_hsa047400.44268231
80GABAergic synapse_Homo sapiens_hsa047270.43717398
81Thyroid hormone synthesis_Homo sapiens_hsa049180.42664853
82Protein export_Homo sapiens_hsa030600.42652911
83Tryptophan metabolism_Homo sapiens_hsa003800.40315374
84Sulfur relay system_Homo sapiens_hsa041220.40185698
85Chemical carcinogenesis_Homo sapiens_hsa052040.39744602
86Drug metabolism - other enzymes_Homo sapiens_hsa009830.37952382
87Glutathione metabolism_Homo sapiens_hsa004800.37819323
88Dorso-ventral axis formation_Homo sapiens_hsa043200.36602193
89Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.35228387
90Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.35032734
91Cholinergic synapse_Homo sapiens_hsa047250.34282555
92Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.34095550
93Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.33423064
94Carbon metabolism_Homo sapiens_hsa012000.32734410
95Retinol metabolism_Homo sapiens_hsa008300.31640961
96Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.30486530
97Purine metabolism_Homo sapiens_hsa002300.30182169
98Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.28451860
99Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.28269626
100Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.26762937

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