TECTA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The tectorial membrane is an extracellular matrix of the inner ear that contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia, and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals. Alpha-tectorin is one of the major noncollagenous components of the tectorial membrane. Mutations in the TECTA gene have been shown to be responsible for autosomal dominant nonsyndromic hearing impairment and a recessive form of sensorineural pre-lingual non-syndromic deafness. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1inner ear receptor cell differentiation (GO:0060113)9.34499991
2regulation of female gonad development (GO:2000194)9.30649609
3hair cell differentiation (GO:0035315)8.98406286
4regulation of somitogenesis (GO:0014807)8.61216770
5piRNA metabolic process (GO:0034587)8.30479626
6regulation of acrosome reaction (GO:0060046)7.90463274
7mechanoreceptor differentiation (GO:0042490)7.66104603
8regulation of meiosis I (GO:0060631)7.52806797
9meiotic cell cycle (GO:0051321)7.40200859
10endocardial cushion morphogenesis (GO:0003203)7.13081741
11retinal cone cell development (GO:0046549)6.56052128
12multicellular organism reproduction (GO:0032504)6.43708358
13DNA methylation involved in gamete generation (GO:0043046)6.36073334
14vitamin catabolic process (GO:0009111)6.33208544
15fat-soluble vitamin catabolic process (GO:0042363)6.33208544
16oocyte development (GO:0048599)6.30251841
17female gamete generation (GO:0007292)5.99447014
18positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.98566146
19positive regulation of histone H3-K4 methylation (GO:0051571)5.95813994
20glycine transport (GO:0015816)5.93761732
21Notch signaling involved in heart development (GO:0061314)5.89471282
22aorta morphogenesis (GO:0035909)5.88772529
23regulation of histone H3-K9 methylation (GO:0051570)5.86761056
24type B pancreatic cell proliferation (GO:0044342)5.80068052
25mesenchyme morphogenesis (GO:0072132)5.76184564
26regulation of cardioblast proliferation (GO:0003264)5.69087227
27regulation of secondary heart field cardioblast proliferation (GO:0003266)5.69087227
28* sensory perception of sound (GO:0007605)5.68706453
29* sensory perception of mechanical stimulus (GO:0050954)5.59539761
30regulation of steroid hormone secretion (GO:2000831)5.43843076
31negative regulation of reproductive process (GO:2000242)5.27854340
32regulation of skeletal muscle cell differentiation (GO:2001014)5.25921082
33regulation of cell maturation (GO:1903429)5.18900324
34positive regulation of gastrulation (GO:2000543)5.05237079
35negative regulation of histone methylation (GO:0031061)4.99759699
36protein kinase C signaling (GO:0070528)4.80172116
37positive regulation of Notch signaling pathway (GO:0045747)4.77573980
38gene silencing by RNA (GO:0031047)4.76413956
39mitotic chromosome condensation (GO:0007076)4.70578740
40lateral sprouting from an epithelium (GO:0060601)4.66895980
41synapsis (GO:0007129)4.52724558
42glycoprotein catabolic process (GO:0006516)4.50576691
43L-amino acid import (GO:0043092)4.48479148
44protein polyglutamylation (GO:0018095)4.48242297
45bone trabecula formation (GO:0060346)4.47261938
46inner ear morphogenesis (GO:0042472)4.46646922
47epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)4.44008308
48neuronal stem cell maintenance (GO:0097150)4.38245940
49heart valve morphogenesis (GO:0003179)4.31570440
50attachment of spindle microtubules to kinetochore (GO:0008608)4.26036373
51cellular sodium ion homeostasis (GO:0006883)4.17938405
52outer ear morphogenesis (GO:0042473)4.16694794
53positive regulation of humoral immune response (GO:0002922)4.16682622
54reproduction (GO:0000003)4.16110303
55cardiac muscle cell proliferation (GO:0060038)4.09845535
56centriole replication (GO:0007099)4.08405359
57protein localization to chromosome, centromeric region (GO:0071459)4.07469608
58synaptonemal complex assembly (GO:0007130)4.03128931
59primitive streak formation (GO:0090009)4.02950923
60regulation of meiosis (GO:0040020)4.01982506
61positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)4.01205530
62phosphorelay signal transduction system (GO:0000160)3.95166632
63mitotic metaphase plate congression (GO:0007080)3.93983519
64cardiac right ventricle morphogenesis (GO:0003215)3.93688056
65planar cell polarity pathway involved in neural tube closure (GO:0090179)3.87908968
66protein localization to kinetochore (GO:0034501)3.86500551
67diterpenoid biosynthetic process (GO:0016102)3.85779967
68positive regulation of reproductive process (GO:2000243)3.83266459
69cardiac ventricle morphogenesis (GO:0003208)3.76199526
70male meiosis I (GO:0007141)3.75185765
71microtubule severing (GO:0051013)3.74298341
72positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.73659886
73positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.73659886
74positive regulation of mitotic sister chromatid separation (GO:1901970)3.73659886
75chromosome organization involved in meiosis (GO:0070192)3.73290028
76heart valve formation (GO:0003188)3.69131737
77lipopolysaccharide biosynthetic process (GO:0009103)3.65476221
78positive regulation of skeletal muscle tissue development (GO:0048643)3.65442022
79regulation of corticosteroid hormone secretion (GO:2000846)3.63650417
80cardiac epithelial to mesenchymal transition (GO:0060317)3.62616360
81phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.61925127
82ventricular septum morphogenesis (GO:0060412)3.61866550
83male meiosis (GO:0007140)3.60680098
84generation of neurons (GO:0048699)3.60155984
85binding of sperm to zona pellucida (GO:0007339)3.59470749
86positive regulation of histone methylation (GO:0031062)3.58448079
87fertilization (GO:0009566)3.58367588
88synaptonemal complex organization (GO:0070193)3.57798167
89regulation of transforming growth factor beta2 production (GO:0032909)3.57515172
90DNA methylation (GO:0006306)3.57476522
91DNA alkylation (GO:0006305)3.57476522
92regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.56649925
93cell aggregation (GO:0098743)3.54532500
94cartilage condensation (GO:0001502)3.54532500
95regulation of steroid hormone biosynthetic process (GO:0090030)3.53043094
96dorsal/ventral axis specification (GO:0009950)3.51669869
97negative regulation of smooth muscle cell migration (GO:0014912)3.49275786
98regulation of histone H3-K4 methylation (GO:0051569)3.47593672
99positive regulation of chromosome segregation (GO:0051984)3.47507919
100regulation of heart morphogenesis (GO:2000826)3.46597023
101cranial nerve development (GO:0021545)3.46396281
102regulation of meiotic cell cycle (GO:0051445)3.45881827
103oogenesis (GO:0048477)3.45010063
104galactose catabolic process (GO:0019388)3.44715840
105regulation of calcium ion-dependent exocytosis (GO:0017158)3.44467982
106cochlea morphogenesis (GO:0090103)3.42955361
107striated muscle cell proliferation (GO:0014855)3.40987004
108righting reflex (GO:0060013)3.40861503
109pathway-restricted SMAD protein phosphorylation (GO:0060389)3.39946765
110neuron fate determination (GO:0048664)3.39507079
111protein K6-linked ubiquitination (GO:0085020)3.39127716
112retinoic acid metabolic process (GO:0042573)3.38709388
113lung epithelium development (GO:0060428)3.37756785
114interkinetic nuclear migration (GO:0022027)3.37657267
115protein localization to chromosome (GO:0034502)3.37641889
116regulation of cell proliferation involved in heart morphogenesis (GO:2000136)3.37596766
117establishment of chromosome localization (GO:0051303)3.37246769
118somatic stem cell division (GO:0048103)3.36066719
119establishment of tissue polarity (GO:0007164)3.35554589
120establishment of planar polarity (GO:0001736)3.35554589
121negative regulation of hormone biosynthetic process (GO:0032353)3.34758167
122pharyngeal system development (GO:0060037)3.33923008
123positive regulation of uterine smooth muscle contraction (GO:0070474)3.33229098
124non-canonical Wnt signaling pathway (GO:0035567)3.32877878
125gene silencing (GO:0016458)3.32177487
126positive regulation of meiosis (GO:0045836)3.30632193
127cochlea development (GO:0090102)3.26571402
128meiotic nuclear division (GO:0007126)3.25539474
129DNA damage induced protein phosphorylation (GO:0006975)3.24341717
130cardiac chamber morphogenesis (GO:0003206)3.24300012
131somite rostral/caudal axis specification (GO:0032525)3.24005118
132stress granule assembly (GO:0034063)3.22799575
133nephron tubule development (GO:0072080)3.22101470
134ectodermal placode formation (GO:0060788)3.22053251
135CENP-A containing nucleosome assembly (GO:0034080)3.21759159
136synaptic vesicle exocytosis (GO:0016079)3.21496287
137cell surface receptor signaling pathway involved in heart development (GO:0061311)3.21125171
138regulation of reproductive process (GO:2000241)3.20725100
139single fertilization (GO:0007338)3.18673541
140translesion synthesis (GO:0019985)3.18475519
141detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.16348961
142metaphase plate congression (GO:0051310)3.14662449
143amino acid import (GO:0043090)3.13558550
144regulation of histone methylation (GO:0031060)3.13332297
145regulation of spindle organization (GO:0090224)3.13207352
146negative regulation of hormone metabolic process (GO:0032351)3.12333809
147histone H3-K9 demethylation (GO:0033169)3.12281276
148ventricular trabecula myocardium morphogenesis (GO:0003222)3.09590392
149labyrinthine layer development (GO:0060711)3.09515009
150face development (GO:0060324)3.07772743
151positive regulation of meiotic cell cycle (GO:0051446)3.07090796
152meiosis I (GO:0007127)3.06426801
153metanephric mesenchyme development (GO:0072075)3.06131622
154atrioventricular valve morphogenesis (GO:0003181)3.05627149
155lipopolysaccharide metabolic process (GO:0008653)3.05070898
156regulation of female receptivity (GO:0045924)3.04322536
157retinal ganglion cell axon guidance (GO:0031290)3.03928031
158relaxation of smooth muscle (GO:0044557)3.03017554
159neuroblast proliferation (GO:0007405)3.00355491
160meiotic cell cycle process (GO:1903046)3.00080972
161negative regulation of execution phase of apoptosis (GO:1900118)2.96431591
162nerve development (GO:0021675)2.96272173
163Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.94918596
164sperm-egg recognition (GO:0035036)2.94177537
165regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.93995347
166chromatin remodeling at centromere (GO:0031055)2.93644052
167regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.93093902
168reflex (GO:0060004)2.91550686
169cerebral cortex neuron differentiation (GO:0021895)2.91403619
170chromatin assembly (GO:0031497)2.90667519
171regulation of Notch signaling pathway (GO:0008593)2.90635136
172middle ear morphogenesis (GO:0042474)2.90372752
173regulation of water loss via skin (GO:0033561)2.89269313
174protein localization to cell surface (GO:0034394)2.88659990
175inner ear development (GO:0048839)2.86602814
176negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.86427534
177dopamine biosynthetic process (GO:0042416)2.86218005
178negative regulation of circadian rhythm (GO:0042754)2.85940389
179regulation of alkaline phosphatase activity (GO:0010692)2.85926620
180digestive tract morphogenesis (GO:0048546)2.84804201
181type B pancreatic cell development (GO:0003323)2.82318924
182calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.82069335
183regulation of G2/M transition of mitotic cell cycle (GO:0010389)2.81438435
184renal tubule development (GO:0061326)2.81079807
185cardiac septum morphogenesis (GO:0060411)2.80761673
186negative regulation of cAMP-mediated signaling (GO:0043951)2.80639761
187regulation of establishment of planar polarity (GO:0090175)2.79934412
188negative regulation of histone modification (GO:0031057)2.79596450
189cellular response to pH (GO:0071467)2.79032007
190lens fiber cell development (GO:0070307)2.78903169
191regulation of chemokine-mediated signaling pathway (GO:0070099)2.76001051
192endothelial cell differentiation (GO:0045446)2.74783237
193nephron tubule formation (GO:0072079)2.73687040
194muscle cell proliferation (GO:0033002)2.70346754
195regulation of cardioblast differentiation (GO:0051890)2.69565390
196artery morphogenesis (GO:0048844)2.67136063
197auditory receptor cell differentiation (GO:0042491)14.1582010
198pentose metabolic process (GO:0019321)11.1007664
199regulation of DNA methylation (GO:0044030)10.5100034

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat6.01982677
2TP63_17297297_ChIP-ChIP_HaCaT_Human5.63825698
3TRIM28_21343339_ChIP-Seq_HEK293_Human5.26808918
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.42893171
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.30169298
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.29009009
7EZH2_22144423_ChIP-Seq_EOC_Human2.81812697
8GBX2_23144817_ChIP-Seq_PC3_Human2.75442443
9ERG_21242973_ChIP-ChIP_JURKAT_Human2.60436912
10CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.55843861
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.33746723
12ZNF217_24962896_ChIP-Seq_MCF-7_Human2.30352908
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.30274496
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.30274496
15JARID2_20064375_ChIP-Seq_MESCs_Mouse2.28059365
16KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.20082762
17KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.20082762
18KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.20082762
19SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.04087587
20E2F7_22180533_ChIP-Seq_HELA_Human2.01255731
21HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.00397663
22RNF2_27304074_Chip-Seq_ESCs_Mouse1.99045079
23ESR2_21235772_ChIP-Seq_MCF-7_Human1.98828432
24SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.97487613
25EZH2_27294783_Chip-Seq_ESCs_Mouse1.96941136
26WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.96438057
27SUZ12_27294783_Chip-Seq_ESCs_Mouse1.85061730
28ESR1_21235772_ChIP-Seq_MCF-7_Human1.84080860
29AHR_22903824_ChIP-Seq_MCF-7_Human1.83799404
30SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.82350836
31SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.81513935
32JARID2_20075857_ChIP-Seq_MESCs_Mouse1.80199450
33ARNT_22903824_ChIP-Seq_MCF-7_Human1.79492292
34ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.78362076
35SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.78248440
36EED_16625203_ChIP-ChIP_MESCs_Mouse1.70678107
37SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.69209798
38TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.68780548
39GATA1_26923725_Chip-Seq_HPCs_Mouse1.68064258
40EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.67669942
41TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.66821565
42POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.66821565
43WT1_25993318_ChIP-Seq_PODOCYTE_Human1.65836797
44RING1B_27294783_Chip-Seq_ESCs_Mouse1.60519811
45EZH2_27304074_Chip-Seq_ESCs_Mouse1.58416227
46DROSHA_22980978_ChIP-Seq_HELA_Human1.57109516
47* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.56233073
48MTF2_20144788_ChIP-Seq_MESCs_Mouse1.54320150
49TOP2B_26459242_ChIP-Seq_MCF-7_Human1.54029226
50SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.53690018
51FOXM1_23109430_ChIP-Seq_U2OS_Human1.53218379
52EP300_21415370_ChIP-Seq_HL-1_Mouse1.50353740
53TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.45162376
54NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.44869333
55REST_21632747_ChIP-Seq_MESCs_Mouse1.44239618
56TP63_19390658_ChIP-ChIP_HaCaT_Human1.40409778
57RING1B_27294783_Chip-Seq_NPCs_Mouse1.39465532
58NOTCH1_21737748_ChIP-Seq_TLL_Human1.38610913
59BMI1_23680149_ChIP-Seq_NPCS_Mouse1.38351280
60TCF4_23295773_ChIP-Seq_U87_Human1.37898486
61UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.37028430
62* SMAD4_21799915_ChIP-Seq_A2780_Human1.36168966
63MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.35671833
64TP53_18474530_ChIP-ChIP_U2OS_Human1.35577104
65CTBP1_25329375_ChIP-Seq_LNCAP_Human1.32471445
66PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.32004108
67RNF2_27304074_Chip-Seq_NSC_Mouse1.30888059
68PRDM14_20953172_ChIP-Seq_ESCs_Human1.30675850
69AR_25329375_ChIP-Seq_VCAP_Human1.30024702
70TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.28634681
71FOXO3_23340844_ChIP-Seq_DLD1_Human1.27643581
72VDR_24787735_ChIP-Seq_THP-1_Human1.23990151
73CTBP2_25329375_ChIP-Seq_LNCAP_Human1.23801643
74RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.23702272
75DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.22309683
76CLOCK_20551151_ChIP-Seq_293T_Human1.21676757
77KDM2B_26808549_Chip-Seq_K562_Human1.21530910
78RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21194086
79MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.21070737
80PIAS1_25552417_ChIP-Seq_VCAP_Human1.20818484
81* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.19605285
82* CBP_20019798_ChIP-Seq_JUKART_Human1.19605285
83FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.18991192
84RUNX2_22187159_ChIP-Seq_PCA_Human1.18984428
85STAT3_23295773_ChIP-Seq_U87_Human1.18226048
86SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.15278780
87CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15097179
88P300_19829295_ChIP-Seq_ESCs_Human1.15090122
89PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.15047954
90BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.14693479
91ZFP281_18757296_ChIP-ChIP_E14_Mouse1.13411904
92NR3C1_23031785_ChIP-Seq_PC12_Mouse1.13115658
93GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11654983
94* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11607112
95AR_21572438_ChIP-Seq_LNCaP_Human1.11187506
96TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.10567016
97TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10425378
98TP53_20018659_ChIP-ChIP_R1E_Mouse1.10362311
99SALL1_21062744_ChIP-ChIP_HESCs_Human1.10137294
100ISL1_27105846_Chip-Seq_CPCs_Mouse1.09753064
101STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.07776249
102ESR1_20079471_ChIP-ChIP_T-47D_Human1.07435856
103SOX9_24532713_ChIP-Seq_HFSC_Mouse1.07027655
104* SMAD4_21741376_ChIP-Seq_EPCs_Human1.06921331
105MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.06779714
106EWS_26573619_Chip-Seq_HEK293_Human1.06739215
107TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.06591863
108BP1_19119308_ChIP-ChIP_Hs578T_Human1.06529043
109SMAD3_21741376_ChIP-Seq_ESCs_Human1.05639243
110LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04227699
111FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.03916088
112ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.03180088
113EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.01631746
114ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.01498458
115AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.00970393
116ZFP281_27345836_Chip-Seq_ESCs_Mouse1.00260817
117SOX2_21211035_ChIP-Seq_LN229_Gbm1.00048855
118ESR1_15608294_ChIP-ChIP_MCF-7_Human0.99861512
119PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.98610678
120KDM2B_26808549_Chip-Seq_DND41_Human0.98183421
121GF1_26923725_Chip-Seq_HPCs_Mouse0.97826426
122KDM2B_26808549_Chip-Seq_JURKAT_Human0.97771757
123RUNX1_27514584_Chip-Seq_MCF-7_Human0.96345993
124TAL1_26923725_Chip-Seq_HPCs_Mouse0.95942863
125GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.93888186
126* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93170144
127IKZF1_21737484_ChIP-ChIP_HCT116_Human0.92860451
128CBX2_27304074_Chip-Seq_ESCs_Mouse0.91600205
129POU3F2_20337985_ChIP-ChIP_501MEL_Human0.91447660
130KDM2B_26808549_Chip-Seq_SUP-B15_Human0.90991840
131KLF5_25053715_ChIP-Seq_YYC3_Human0.90747728
132CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.90742123
133TAF15_26573619_Chip-Seq_HEK293_Human0.90684309
134* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.90668373
135SMAD3_21741376_ChIP-Seq_EPCs_Human0.90544179
136IRF1_19129219_ChIP-ChIP_H3396_Human0.88781025
137NANOG_20526341_ChIP-Seq_ESCs_Human0.88551126
138SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88164690
139SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.88066583
140LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87503338
141CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.87328341
142NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.86611577
143FOXM1_26456572_ChIP-Seq_MCF-7_Human0.86308002
144GATA3_24758297_ChIP-Seq_MCF-7_Human0.86092539
145ZNF274_21170338_ChIP-Seq_K562_Hela0.85415784
146EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.84916133
147FOXA2_19822575_ChIP-Seq_HepG2_Human0.83897187
148AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.83588676
149KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.82895073
150ZNF263_19887448_ChIP-Seq_K562_Human0.82809829
151* DNAJC2_21179169_ChIP-ChIP_NT2_Human0.82387938
152MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.82124067
153CTCF_27219007_Chip-Seq_Bcells_Human0.81196974
154FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.80934929
155ZFP57_27257070_Chip-Seq_ESCs_Mouse0.80861999
156* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.80819950
157NR3C1_21868756_ChIP-Seq_MCF10A_Human0.79526973
158AR_19668381_ChIP-Seq_PC3_Human0.77094229
159MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.75846978
160TBX3_20139965_ChIP-Seq_ESCs_Mouse0.75704178
161TBX3_20139965_ChIP-Seq_MESCs_Mouse0.75588786
162KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.75494340
163BCAT_22108803_ChIP-Seq_LS180_Human0.75269739
164TP53_22573176_ChIP-Seq_HFKS_Human0.74880028

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003878_abnormal_ear_physiology8.62424045
2MP0005377_hearing/vestibular/ear_phenot8.62424045
3MP0001485_abnormal_pinna_reflex8.03138393
4MP0003718_maternal_effect7.51023198
5* MP0003879_abnormal_hair_cell6.82089232
6MP0008877_abnormal_DNA_methylation4.76664949
7MP0006292_abnormal_olfactory_placode4.35470830
8* MP0000026_abnormal_inner_ear4.14889606
9* MP0001963_abnormal_hearing_physiology3.77536411
10MP0005394_taste/olfaction_phenotype3.66607014
11MP0005499_abnormal_olfactory_system3.66607014
12MP0005395_other_phenotype3.04091443
13MP0003890_abnormal_embryonic-extraembry3.00503590
14MP0008057_abnormal_DNA_replication2.61316452
15MP0003941_abnormal_skin_development2.52847622
16MP0002139_abnormal_hepatobiliary_system2.46819271
17MP0001486_abnormal_startle_reflex2.43583760
18MP0005248_abnormal_Harderian_gland2.41014458
19MP0002234_abnormal_pharynx_morphology2.20905697
20MP0002653_abnormal_ependyma_morphology2.20873381
21MP0003699_abnormal_female_reproductive2.18764958
22MP0001929_abnormal_gametogenesis2.16292014
23MP0002210_abnormal_sex_determination2.11593807
24MP0005646_abnormal_pituitary_gland2.05240037
25MP0002138_abnormal_hepatobiliary_system1.92658286
26MP0005360_urolithiasis1.89739531
27MP0003121_genomic_imprinting1.86121371
28MP0000566_synostosis1.85221383
29MP0005410_abnormal_fertilization1.83772193
30MP0009780_abnormal_chondrocyte_physiolo1.83710640
31MP0004885_abnormal_endolymph1.79648619
32MP0004742_abnormal_vestibular_system1.76821198
33MP0003938_abnormal_ear_development1.75215418
34MP0003693_abnormal_embryo_hatching1.73531343
35MP0000653_abnormal_sex_gland1.67807237
36MP0000534_abnormal_ureter_morphology1.63717529
37MP0002161_abnormal_fertility/fecundity1.62971071
38MP0003183_abnormal_peptide_metabolism1.61379417
39MP0003950_abnormal_plasma_membrane1.60899380
40MP0002249_abnormal_larynx_morphology1.57856154
41MP0003942_abnormal_urinary_system1.56242146
42MP0010234_abnormal_vibrissa_follicle1.53868482
43MP0008058_abnormal_DNA_repair1.51764803
44MP0003077_abnormal_cell_cycle1.48960296
45MP0001984_abnormal_olfaction1.48460996
46MP0000049_abnormal_middle_ear1.41686949
47MP0005623_abnormal_meninges_morphology1.41052635
48MP0004142_abnormal_muscle_tone1.40090958
49MP0001849_ear_inflammation1.38046258
50MP0001145_abnormal_male_reproductive1.34708225
51MP0003698_abnormal_male_reproductive1.33979926
52MP0010678_abnormal_skin_adnexa1.33801817
53MP0003136_yellow_coat_color1.33481357
54MP0002160_abnormal_reproductive_system1.32688706
55MP0004134_abnormal_chest_morphology1.26283834
56MP0010094_abnormal_chromosome_stability1.24088897
57MP0000383_abnormal_hair_follicle1.20504624
58MP0004270_analgesia1.19492849
59MP0002734_abnormal_mechanical_nocicepti1.17492674
60MP0010307_abnormal_tumor_latency1.15400212
61MP0001346_abnormal_lacrimal_gland1.14159711
62MP0001119_abnormal_female_reproductive1.13649308
63MP0000762_abnormal_tongue_morphology1.13087369
64MP0002932_abnormal_joint_morphology1.10725909
65MP0005551_abnormal_eye_electrophysiolog1.09886073
66MP0002089_abnormal_postnatal_growth/wei1.09265125
67MP0005647_abnormal_sex_gland1.08823966
68MP0003111_abnormal_nucleus_morphology1.07152134
69MP0003705_abnormal_hypodermis_morpholog1.06459589
70MP0003635_abnormal_synaptic_transmissio1.05303132
71MP0000427_abnormal_hair_cycle1.04464249
72MP0010030_abnormal_orbit_morphology1.04415044
73MP0001664_abnormal_digestion1.04123870
74MP0004264_abnormal_extraembryonic_tissu1.03463837
75MP0008932_abnormal_embryonic_tissue1.02863006
76MP0002752_abnormal_somatic_nervous1.00405169
77MP0010368_abnormal_lymphatic_system0.99808897
78MP0003115_abnormal_respiratory_system0.99366560
79MP0000428_abnormal_craniofacial_morphol0.96236065
80MP0009384_cardiac_valve_regurgitation0.94781897
81MP0005508_abnormal_skeleton_morphology0.93580299
82MP0001730_embryonic_growth_arrest0.93495083
83MP0008995_early_reproductive_senescence0.93493002
84MP0002102_abnormal_ear_morphology0.93445122
85MP0001299_abnormal_eye_distance/0.92955350
86MP0002735_abnormal_chemical_nociception0.91644705
87MP0005389_reproductive_system_phenotype0.89378208
88MP0001986_abnormal_taste_sensitivity0.88964196
89MP0005423_abnormal_somatic_nervous0.87474209
90MP0002277_abnormal_respiratory_mucosa0.87304762
91MP0009745_abnormal_behavioral_response0.86728457
92MP0002184_abnormal_innervation0.86037579
93MP0002009_preneoplasia0.84324148
94MP0004272_abnormal_basement_membrane0.84310105
95MP0000613_abnormal_salivary_gland0.83307985
96MP0002063_abnormal_learning/memory/cond0.81498570
97MP0003195_calcinosis0.79567010
98MP0002233_abnormal_nose_morphology0.78595638
99MP0001286_abnormal_eye_development0.78314761
100MP0002116_abnormal_craniofacial_bone0.76938599
101MP0001324_abnormal_eye_pigmentation0.75961674
102MP0009250_abnormal_appendicular_skeleto0.75958072
103MP0002572_abnormal_emotion/affect_behav0.75085699
104MP0004043_abnormal_pH_regulation0.74756900
105MP0009053_abnormal_anal_canal0.74004573
106MP0009840_abnormal_foam_cell0.73960416
107MP0000163_abnormal_cartilage_morphology0.73871384
108MP0003880_abnormal_central_pattern0.73632344
109MP0002115_abnormal_skeleton_extremities0.72457063
110MP0005380_embryogenesis_phenotype0.72348576
111MP0001672_abnormal_embryogenesis/_devel0.72348576
112MP0002638_abnormal_pupillary_reflex0.70472924
113MP0004811_abnormal_neuron_physiology0.70047995
114MP0002282_abnormal_trachea_morphology0.69038654
115MP0005085_abnormal_gallbladder_physiolo0.68134563
116MP0001340_abnormal_eyelid_morphology0.67168641
117MP0003283_abnormal_digestive_organ0.66816758
118MP0003252_abnormal_bile_duct0.66533742
119MP0002882_abnormal_neuron_morphology0.64586885
120MP0002229_neurodegeneration0.64154043
121MP0008438_abnormal_cutaneous_collagen0.63535966
122MP0004858_abnormal_nervous_system0.63336193
123MP0003755_abnormal_palate_morphology0.63226803
124MP0000579_abnormal_nail_morphology0.60759020
125MP0000778_abnormal_nervous_system0.60138861
126MP0005503_abnormal_tendon_morphology0.59022060
127MP0002111_abnormal_tail_morphology0.57861473
128MP0002127_abnormal_cardiovascular_syste0.57387830
129MP0002109_abnormal_limb_morphology0.57328512
130MP0002557_abnormal_social/conspecific_i0.56760379
131MP0000631_abnormal_neuroendocrine_gland0.54940057
132MP0002938_white_spotting0.54897856
133MP0000733_abnormal_muscle_development0.51123621
134MP0003935_abnormal_craniofacial_develop0.50887299
135MP0004859_abnormal_synaptic_plasticity0.50394459
136MP0001501_abnormal_sleep_pattern0.49845179
137MP0001958_emphysema0.49738443
138MP0000350_abnormal_cell_proliferation0.49513135
139MP0002751_abnormal_autonomic_nervous0.48808331
140MP0003861_abnormal_nervous_system0.48742805
141MP0000467_abnormal_esophagus_morphology0.47731086
142MP0001502_abnormal_circadian_rhythm0.47617365
143MP0005076_abnormal_cell_differentiation0.47430093
144MP0003119_abnormal_digestive_system0.46994553
145MP0005195_abnormal_posterior_eye0.46944721
146MP0002697_abnormal_eye_size0.46644472
147MP0000537_abnormal_urethra_morphology0.45994899
148MP0004145_abnormal_muscle_electrophysio0.45275192
149MP0002067_abnormal_sensory_capabilities0.44333362
150MP0008789_abnormal_olfactory_epithelium0.43924342
151MP0006276_abnormal_autonomic_nervous0.43771663
152MP0000767_abnormal_smooth_muscle0.41300388
153MP0000432_abnormal_head_morphology0.40348555
154MP0002092_abnormal_eye_morphology0.39217688
155MP0004381_abnormal_hair_follicle0.39165909
156MP0001270_distended_abdomen0.38155991
157MP0002177_abnormal_outer_ear0.38045458
158MP0005187_abnormal_penis_morphology0.38003365
159MP0002113_abnormal_skeleton_development0.37674189
160MP0002085_abnormal_embryonic_tissue0.37407200
161MP0002084_abnormal_developmental_patter0.37040851
162MP0010352_gastrointestinal_tract_polyps0.35976440
163MP0002796_impaired_skin_barrier0.35332443
164* MP0002272_abnormal_nervous_system0.35050317
165MP0001943_abnormal_respiration0.33096935
166MP0001293_anophthalmia0.32944914
167MP0009278_abnormal_bone_marrow0.32789492
168MP0003567_abnormal_fetal_cardiomyocyte0.32186159

Predicted human phenotypes

RankGene SetZ-score
1Epiphyseal dysplasia (HP:0002656)8.89367682
2Aplasia/Hypoplasia of the pubic bone (HP:0009104)7.50901166
3Mixed hearing impairment (HP:0000410)6.27832170
4Hypoplastic ischia (HP:0003175)6.22536888
5Vitreoretinal degeneration (HP:0000655)5.57125807
6Abnormality of the ischium (HP:0003174)5.48667631
7Aplasia/Hypoplasia of the fovea (HP:0008060)5.38486820
8Hypoplasia of the fovea (HP:0007750)5.38486820
9Humeroradial synostosis (HP:0003041)5.34599523
10Synostosis involving the elbow (HP:0003938)5.34599523
11Severe Myopia (HP:0011003)5.30194904
12Abnormality of the pubic bones (HP:0003172)5.29228194
13Supernumerary spleens (HP:0009799)5.26322853
14Osteomalacia (HP:0002749)5.21462879
15Anterior segment dysgenesis (HP:0007700)5.14396392
16Male infertility (HP:0003251)4.96312463
17Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)4.76890955
18Abnormality of abdominal situs (HP:0011620)4.68886423
19Abdominal situs inversus (HP:0003363)4.68886423
20Anomalous pulmonary venous return (HP:0010772)4.58518529
21Oligodactyly (HP:0012165)4.56610206
22Abnormality of the fovea (HP:0000493)4.47205713
23Abnormal auditory evoked potentials (HP:0006958)4.35898344
24Lip pit (HP:0100267)4.26456864
25Irregular epiphyses (HP:0010582)4.25338763
26Impulsivity (HP:0100710)4.24086793
27Facial hemangioma (HP:0000329)4.14291001
28Bell-shaped thorax (HP:0001591)4.13315081
29Congenital sensorineural hearing impairment (HP:0008527)4.10779275
30Septo-optic dysplasia (HP:0100842)4.02388971
31Mild short stature (HP:0003502)4.00105062
32Vertebral clefting (HP:0008428)3.98856727
33Abnormality of the pulmonary veins (HP:0011718)3.97645925
34Hypophosphatemic rickets (HP:0004912)3.93057726
35Arterial tortuosity (HP:0005116)3.84842392
36Cholecystitis (HP:0001082)3.84656882
37Abnormal gallbladder physiology (HP:0012438)3.84656882
38Infertility (HP:0000789)3.70408123
39Enlarged epiphyses (HP:0010580)3.58187632
40Morphological abnormality of the middle ear (HP:0008609)3.54589522
41Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)3.53845731
42Absent epiphyses (HP:0010577)3.53845731
43Abnormal vertebral ossification (HP:0100569)3.46150592
44Azoospermia (HP:0000027)3.45075165
45Myokymia (HP:0002411)3.43444840
46Aplasia/Hypoplasia of the macula (HP:0008059)3.40838102
47Gonadotropin excess (HP:0000837)3.35646692
48Vascular tortuosity (HP:0004948)3.34920934
49Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.32769906
50Abnormality of the labia minora (HP:0012880)3.26976089
51Absent septum pellucidum (HP:0001331)3.24366029
52Bilateral microphthalmos (HP:0007633)3.14344108
53Aplasia/Hypoplasia affecting the retina (HP:0008061)3.12453485
54Renal dysplasia (HP:0000110)3.11502530
55Median cleft lip (HP:0000161)3.05834607
56Apathy (HP:0000741)3.02965757
57Alacrima (HP:0000522)3.01517671
58Abnormality of the vitreous humor (HP:0004327)2.96323360
59Absent eyelashes (HP:0000561)2.95753671
60Maternal diabetes (HP:0009800)2.93659977
61Diminished motivation (HP:0000745)2.92311393
62Osteoarthritis (HP:0002758)2.92227070
63Abnormality of the intervertebral disk (HP:0005108)2.88181664
64Aplasia involving bones of the upper limbs (HP:0009823)2.87956243
65Aplasia of the phalanges of the hand (HP:0009802)2.87956243
66Aplasia involving bones of the extremities (HP:0009825)2.87956243
67Truncal obesity (HP:0001956)2.86654258
68Protuberant abdomen (HP:0001538)2.86343561
69Urethral obstruction (HP:0000796)2.81119698
70Short tibia (HP:0005736)2.80491125
71Recurrent corneal erosions (HP:0000495)2.80090849
72Exostoses (HP:0100777)2.77598209
73Vertebral arch anomaly (HP:0008438)2.75139386
74Premature ovarian failure (HP:0008209)2.74759576
75Flattened epiphyses (HP:0003071)2.69077080
76Abnormality of the septum pellucidum (HP:0007375)2.67657270
77Abnormality of the lacrimal duct (HP:0011481)2.67450086
78Aplasia/Hypoplasia of the tibia (HP:0005772)2.67196789
79Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.66348274
80Glossoptosis (HP:0000162)2.65165192
81Partial duplication of thumb phalanx (HP:0009944)2.65143368
82Morphological abnormality of the inner ear (HP:0011390)2.60703847
83Malnutrition (HP:0004395)2.59353076
84Chromsome breakage (HP:0040012)2.58444535
85Capillary hemangiomas (HP:0005306)2.58123394
86Periauricular skin pits (HP:0100277)2.57991118
87Preauricular pit (HP:0004467)2.57991118
88Genu varum (HP:0002970)2.53038620
89Platyspondyly (HP:0000926)2.51985337
90Abnormal spermatogenesis (HP:0008669)2.49909293
91Chromosomal breakage induced by crosslinking agents (HP:0003221)2.49580028
92Enlarged penis (HP:0000040)2.47495198
93Abnormal ciliary motility (HP:0012262)2.46963728
94Synostosis of carpal bones (HP:0005048)2.44334812
95Proximal tubulopathy (HP:0000114)2.43052181
96Optic nerve hypoplasia (HP:0000609)2.42926532
97Hypokinesia (HP:0002375)2.42252175
98Dysdiadochokinesis (HP:0002075)2.42236742
99Decreased lacrimation (HP:0000633)2.37682401
100Occipital encephalocele (HP:0002085)2.35099114
101Wrist flexion contracture (HP:0001239)2.34197267
102Partial duplication of the phalanx of hand (HP:0009999)2.32546538
103Abnormality of the nasolacrimal system (HP:0000614)2.32546192
104Papillary thyroid carcinoma (HP:0002895)2.31170416
105Aplasia/Hypoplasia involving the pelvis (HP:0009103)2.28876359
106Aplasia of the musculature (HP:0100854)2.28118664
107Spinal cord compression (HP:0002176)2.27484145
108Fair hair (HP:0002286)2.26684099
109Meningocele (HP:0002435)2.24930871
110Abnormality of the anterior chamber (HP:0000593)2.24668872
111Increased circulating renin level (HP:0000848)2.24131052
112Conjunctival telangiectasia (HP:0000524)2.20876629
113Bicuspid aortic valve (HP:0001647)2.19549253
114Generalized aminoaciduria (HP:0002909)2.17128089
115Abnormality of calcium-phosphate metabolism (HP:0100530)2.16690607
116Aplasia/Hypoplasia of the tongue (HP:0010295)2.13984403
117Bicornuate uterus (HP:0000813)2.13852336
118Sprengel anomaly (HP:0000912)2.13087393
119Metaphyseal irregularity (HP:0003025)2.12722818
120Midline defect of the nose (HP:0004122)2.11280406
121Bundle branch block (HP:0011710)2.11125953
122Spondylolisthesis (HP:0003302)2.08071820
123Unilateral renal agenesis (HP:0000122)2.07391079
124Striae distensae (HP:0001065)2.06738081
125Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.05244394
126Muscle stiffness (HP:0003552)2.04776012
127Abnormality of the phalanges of the hallux (HP:0010057)2.03947529
128Abnormal lung lobation (HP:0002101)2.03095376
129Knee flexion contracture (HP:0006380)2.02698001
130Hip contracture (HP:0003273)2.02293142
131Down-sloping shoulders (HP:0200021)2.02273095
132Skin pits (HP:0100276)2.01727214
133Preauricular skin tag (HP:0000384)2.01285695
134Thyroid carcinoma (HP:0002890)1.99225978
135Nasolacrimal duct obstruction (HP:0000579)1.98912447
136Rhizomelia (HP:0008905)1.98389410
137Gaze-evoked nystagmus (HP:0000640)1.97313793
138Dysmetric saccades (HP:0000641)1.96436730
139Limited hip movement (HP:0008800)1.96097588
140Abnormality of the humeroradial joint (HP:0100744)1.93737258
141Abnormality of the salivary glands (HP:0010286)1.93505161
142Potter facies (HP:0002009)1.93184463
143Facial shape deformation (HP:0011334)1.93184463
144Germ cell neoplasia (HP:0100728)1.93086615
145Hydroureter (HP:0000072)1.92249601
146Abnormality of aromatic amino acid family metabolism (HP:0004338)1.91709966
147Flared metaphyses (HP:0003015)1.88198781
148Heterotopia (HP:0002282)1.88163174
149Small epiphyses (HP:0010585)1.86929056
150Abnormality of midbrain morphology (HP:0002418)1.86293400
151Molar tooth sign on MRI (HP:0002419)1.86293400
152Skull defect (HP:0001362)1.85689880
153Neoplasm of the oral cavity (HP:0100649)1.85042411
154Abnormal respiratory motile cilium physiology (HP:0012261)1.84664383
155Micromelia (HP:0002983)1.83980780
156Hypercortisolism (HP:0001578)1.78890318
157Loss of speech (HP:0002371)1.78223532
158Abnormality of the labia (HP:0000058)1.77269740
159Posterior subcapsular cataract (HP:0007787)1.77173843
160Cupped ear (HP:0000378)1.76860254
161Chorioretinal atrophy (HP:0000533)1.76328044
162Nephroblastoma (Wilms tumor) (HP:0002667)1.76247266
163Skin tags (HP:0010609)1.76081240
164Anhidrosis (HP:0000970)1.76014590
165Oligodactyly (hands) (HP:0001180)1.75455678
166Limb hypertonia (HP:0002509)1.75420600
167Hypoplastic pelvis (HP:0008839)1.75121816
168Lower limb hyperreflexia (HP:0002395)1.74811706
169Bile duct proliferation (HP:0001408)1.73135602
170Abnormal biliary tract physiology (HP:0012439)1.73135602
171Arachnodactyly (HP:0001166)1.72295164
172Hypoplasia of the ulna (HP:0003022)1.71793438
173Hemivertebrae (HP:0002937)1.71518674
174Hypoplastic ilia (HP:0000946)1.71128539
175Progressive cerebellar ataxia (HP:0002073)1.70679206
176Medial flaring of the eyebrow (HP:0010747)1.70435067
177Plagiocephaly (HP:0001357)1.69941470
178Rhinitis (HP:0012384)1.69228149
179Neonatal short-limb short stature (HP:0008921)1.68996887
180Sensory axonal neuropathy (HP:0003390)1.68643507
181Embryonal renal neoplasm (HP:0011794)1.67527774
182Hypoplastic nipples (HP:0002557)1.66249181
183Aplasia/Hypoplasia of the ulna (HP:0006495)1.65852551
184Carpal synostosis (HP:0009702)1.63779357
185Aortic dissection (HP:0002647)1.61345070
186Pterygium (HP:0001059)1.58756890
187Delayed epiphyseal ossification (HP:0002663)1.58148756

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ARAF5.54469759
2LATS13.24225199
3BRAF2.89690617
4NEK62.87641149
5TAOK32.79914099
6STK242.69131650
7EPHB12.61929839
8TRPM72.52028934
9MOS2.41333036
10PINK12.39509267
11TTK2.33254487
12CDK122.09124286
13TNIK2.02352616
14DDR212.7573819
15AURKA1.99094412
16DYRK1B1.88560702
17NTRK11.85225309
18TRIB31.83982948
19CDK91.69316201
20EPHA31.68699284
21CDC71.68500853
22RAF11.64853879
23FGFR31.56064170
24PRKCI1.52561011
25PKN21.47268508
26RIPK11.46833327
27UHMK11.44879251
28TRIM281.41949934
29EPHA21.39332655
30NEK21.36033723
31MAPK151.33864966
32MELK1.25068422
33CDK61.20021212
34CDK191.19791668
35EIF2AK31.14403822
36ERBB21.10802616
37CSNK1A1L1.10032487
38PAK31.07723247
39SIK11.07085050
40PDGFRA1.06902797
41PLK11.06699858
42ERBB31.06141365
43CDK71.05530136
44DAPK21.05109317
45MAPK131.04966416
46MAP3K101.04563179
47YES11.02624847
48MAP3K90.98728413
49FGFR40.98673990
50WNK40.98633807
51PIM10.98025436
52PTK60.97924139
53STK390.94489786
54FGFR10.91955656
55MARK30.89752952
56WNK10.83069040
57PAK40.82943376
58WNK30.82498353
59FER0.82181959
60BRSK10.80603017
61CAMK1G0.80539846
62EPHA40.79499794
63HIPK20.79348216
64TNK20.78675693
65BRD40.78411834
66KSR20.78107721
67PRKD30.74972936
68LATS20.74151266
69PNCK0.73458620
70ERBB40.70744081
71ZAK0.69964899
72BUB10.68863262
73STK30.68506507
74MAP3K80.68298784
75MARK10.68181105
76CHEK10.67955292
77PLK30.65892239
78PRKG10.65621492
79MAP3K20.64713214
80CHEK20.64586315
81NEK10.64216489
82TIE10.62247539
83DMPK0.62171478
84CDK20.62024416
85EPHB20.60485802
86BMPR1B0.58881083
87TGFBR20.58810454
88ACVR1B0.58745196
89RET0.58690635
90CSNK1G10.57497173
91PKN10.57401304
92MAP3K50.56801946
93LRRK20.56431238
94RPS6KL10.55328534
95RPS6KC10.55328534
96NTRK30.55141190
97KSR10.54703004
98IRAK10.54130815
99CSNK1G30.53590026
100PAK60.52340280
101CAMK2A0.51530386
102CSNK1G20.50675592
103ATM0.50390763
104BMX0.48616142
105MAP2K70.47883199
106CDK50.47310450
107TESK20.46364702
108PAK10.46316346
109ALK0.46167191
110RIPK40.45935000
111LMTK20.45922165
112NME10.45406322
113CAMK1D0.44705998
114MAP3K130.44421416
115RPS6KA60.44122109
116BCR0.42524724
117CDK10.42459779
118CDK80.41662813
119MET0.40021430
120TAOK10.37721102
121MAP3K70.37630981
122MKNK20.37537546
123PDK10.37260274
124PRKACA0.37236145
125PDGFRB0.36899067
126AURKB0.36625197
127PRKACB0.36522365
128ROCK20.36126861
129NUAK10.36031106
130PRKCZ0.35909811
131SGK20.35713877
132CAMK40.35355903
133MAP3K40.34873885
134MAPKAPK30.33463548
135SCYL20.33329440
136MTOR0.32312129
137RPS6KA10.31719609
138TGFBR10.31611968
139IRAK20.31499656
140RPS6KA20.30513174
141CASK0.30066540
142PTK20.29706330
143JAK20.29602015
144MARK20.29509348
145PRKCE0.29413752
146CAMK10.29094072
147NEK90.28968966
148GSK3B0.28644930
149MST40.28267618
150TYRO30.28218000
151CSNK1E0.27388787
152CSNK1D0.26923246
153MKNK10.26646806
154PRKCH0.26315178
155MINK10.26077940
156PAK20.25905763
157EGFR0.24957835
158EEF2K0.24774587
159ILK0.24060389
160DYRK20.23882921
161OXSR10.23750939
162STK38L0.22994667
163MAPK100.22884525
164ABL10.22020119
165ATR0.21930252
166SRPK10.21676822
167AKT20.21414384
168PLK40.21409328
169CDC42BPA0.21138469
170NTRK20.20538526

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal transcription factors_Homo sapiens_hsa030224.94696970
2Other types of O-glycan biosynthesis_Homo sapiens_hsa005144.32565045
3Cell cycle_Homo sapiens_hsa041103.68791167
4Oocyte meiosis_Homo sapiens_hsa041143.23756741
5Notch signaling pathway_Homo sapiens_hsa043303.19445328
6Ovarian steroidogenesis_Homo sapiens_hsa049133.14697752
7Basal cell carcinoma_Homo sapiens_hsa052173.06565354
8Mismatch repair_Homo sapiens_hsa034302.91244354
9Hippo signaling pathway_Homo sapiens_hsa043902.85158002
10Dorso-ventral axis formation_Homo sapiens_hsa043202.66206341
11ECM-receptor interaction_Homo sapiens_hsa045122.65520964
12Protein digestion and absorption_Homo sapiens_hsa049742.60522610
13Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.56316353
14Nicotine addiction_Homo sapiens_hsa050332.38490277
15Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.36912445
16Caffeine metabolism_Homo sapiens_hsa002322.32554648
17Base excision repair_Homo sapiens_hsa034102.27727658
18RNA degradation_Homo sapiens_hsa030182.12934834
19Olfactory transduction_Homo sapiens_hsa047402.10422486
20Cell adhesion molecules (CAMs)_Homo sapiens_hsa045142.09845128
21Wnt signaling pathway_Homo sapiens_hsa043101.97899849
22Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.85354836
23Circadian rhythm_Homo sapiens_hsa047101.82342630
24Melanogenesis_Homo sapiens_hsa049161.80748567
25TGF-beta signaling pathway_Homo sapiens_hsa043501.80036109
26Phenylalanine metabolism_Homo sapiens_hsa003601.77313069
27Morphine addiction_Homo sapiens_hsa050321.75979957
28GABAergic synapse_Homo sapiens_hsa047271.73806896
29Adherens junction_Homo sapiens_hsa045201.72772284
30Fanconi anemia pathway_Homo sapiens_hsa034601.69699055
31Tight junction_Homo sapiens_hsa045301.69013007
32Phototransduction_Homo sapiens_hsa047441.68236597
33Lysine degradation_Homo sapiens_hsa003101.67749354
34Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.66932856
35Nucleotide excision repair_Homo sapiens_hsa034201.64931293
36Chronic myeloid leukemia_Homo sapiens_hsa052201.64202377
37Proteoglycans in cancer_Homo sapiens_hsa052051.63467982
38Focal adhesion_Homo sapiens_hsa045101.62483586
39Bladder cancer_Homo sapiens_hsa052191.55738229
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.49175123
41Axon guidance_Homo sapiens_hsa043601.48703981
42Leukocyte transendothelial migration_Homo sapiens_hsa046701.36463611
43Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.35889995
44Folate biosynthesis_Homo sapiens_hsa007901.34821489
45Colorectal cancer_Homo sapiens_hsa052101.33836425
46Synaptic vesicle cycle_Homo sapiens_hsa047211.33584384
47RNA transport_Homo sapiens_hsa030131.29031028
48ErbB signaling pathway_Homo sapiens_hsa040121.26112872
49DNA replication_Homo sapiens_hsa030301.23871988
50Histidine metabolism_Homo sapiens_hsa003401.21803897
51p53 signaling pathway_Homo sapiens_hsa041151.18282320
52Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.16045681
53Endometrial cancer_Homo sapiens_hsa052131.13111495
54Glioma_Homo sapiens_hsa052141.12513531
55Hedgehog signaling pathway_Homo sapiens_hsa043401.12111947
56Dilated cardiomyopathy_Homo sapiens_hsa054141.12082051
57mRNA surveillance pathway_Homo sapiens_hsa030151.10680141
58Estrogen signaling pathway_Homo sapiens_hsa049151.10627049
59Homologous recombination_Homo sapiens_hsa034401.10155396
60Glutamatergic synapse_Homo sapiens_hsa047241.10060587
61MicroRNAs in cancer_Homo sapiens_hsa052061.09820142
62Serotonergic synapse_Homo sapiens_hsa047261.09807686
63ABC transporters_Homo sapiens_hsa020101.04657218
64Circadian entrainment_Homo sapiens_hsa047131.02345724
65Melanoma_Homo sapiens_hsa052181.01949350
66Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.01855204
67Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.99772628
68Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.99280963
69Renal cell carcinoma_Homo sapiens_hsa052110.98986167
70AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.97646719
71Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.96686792
72Pancreatic cancer_Homo sapiens_hsa052120.94235100
73Bile secretion_Homo sapiens_hsa049760.92932339
74Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.89972739
75Fatty acid elongation_Homo sapiens_hsa000620.88493256
76Retinol metabolism_Homo sapiens_hsa008300.87459348
77RNA polymerase_Homo sapiens_hsa030200.86141525
78beta-Alanine metabolism_Homo sapiens_hsa004100.83985087
79Amoebiasis_Homo sapiens_hsa051460.83801769
80Insulin secretion_Homo sapiens_hsa049110.83693196
81Prostate cancer_Homo sapiens_hsa052150.83259704
82Pathways in cancer_Homo sapiens_hsa052000.82943520
83Phosphatidylinositol signaling system_Homo sapiens_hsa040700.81510461
84PI3K-Akt signaling pathway_Homo sapiens_hsa041510.80871280
85Maturity onset diabetes of the young_Homo sapiens_hsa049500.80615172
86Aldosterone synthesis and secretion_Homo sapiens_hsa049250.80149786
87Neurotrophin signaling pathway_Homo sapiens_hsa047220.79803732
88Fatty acid biosynthesis_Homo sapiens_hsa000610.78577226
89Rap1 signaling pathway_Homo sapiens_hsa040150.78003558
90Thyroid cancer_Homo sapiens_hsa052160.77619924
91Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.74009259
92Long-term potentiation_Homo sapiens_hsa047200.73110814
93Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.72205969
94Insulin resistance_Homo sapiens_hsa049310.71764429
95Oxytocin signaling pathway_Homo sapiens_hsa049210.71222246
96Regulation of actin cytoskeleton_Homo sapiens_hsa048100.69534996
97SNARE interactions in vesicular transport_Homo sapiens_hsa041300.68558850
98Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.68440922
99cAMP signaling pathway_Homo sapiens_hsa040240.67427570
100Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.67351078
101Hepatitis C_Homo sapiens_hsa051600.67199935
102Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.66542264
103Small cell lung cancer_Homo sapiens_hsa052220.66173277
104Cocaine addiction_Homo sapiens_hsa050300.65979863
105Thyroid hormone signaling pathway_Homo sapiens_hsa049190.64746771
106Prolactin signaling pathway_Homo sapiens_hsa049170.64527762
107Viral myocarditis_Homo sapiens_hsa054160.64439835
108Thyroid hormone synthesis_Homo sapiens_hsa049180.62835353
109Regulation of autophagy_Homo sapiens_hsa041400.60274542
110GnRH signaling pathway_Homo sapiens_hsa049120.58904157
111Nitrogen metabolism_Homo sapiens_hsa009100.58614443
112Cardiac muscle contraction_Homo sapiens_hsa042600.58232694
113Prion diseases_Homo sapiens_hsa050200.58082886
114Long-term depression_Homo sapiens_hsa047300.57691155
115Calcium signaling pathway_Homo sapiens_hsa040200.57255006
116Tyrosine metabolism_Homo sapiens_hsa003500.56486698
117FoxO signaling pathway_Homo sapiens_hsa040680.55696924
118Transcriptional misregulation in cancer_Homo sapiens_hsa052020.55023917
119Central carbon metabolism in cancer_Homo sapiens_hsa052300.53366485
120Amphetamine addiction_Homo sapiens_hsa050310.51539203
121HTLV-I infection_Homo sapiens_hsa051660.51513907
122Insulin signaling pathway_Homo sapiens_hsa049100.51135399
123Toxoplasmosis_Homo sapiens_hsa051450.50943640
124Dopaminergic synapse_Homo sapiens_hsa047280.49568296
125Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49554807
126Choline metabolism in cancer_Homo sapiens_hsa052310.49218311
127Ras signaling pathway_Homo sapiens_hsa040140.49193008
128Type II diabetes mellitus_Homo sapiens_hsa049300.48969459
129Gastric acid secretion_Homo sapiens_hsa049710.48731984
130MAPK signaling pathway_Homo sapiens_hsa040100.48017782
131Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.47180931
132Purine metabolism_Homo sapiens_hsa002300.46961517
133Gap junction_Homo sapiens_hsa045400.46609784
134Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.45580289
135Taste transduction_Homo sapiens_hsa047420.44356944
136Non-small cell lung cancer_Homo sapiens_hsa052230.43523952
137Phospholipase D signaling pathway_Homo sapiens_hsa040720.42708158
138mTOR signaling pathway_Homo sapiens_hsa041500.42236950
139Hepatitis B_Homo sapiens_hsa051610.41582158
140Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.41504920
141Propanoate metabolism_Homo sapiens_hsa006400.41010598
142Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.39652954
143Endocytosis_Homo sapiens_hsa041440.39036436
144Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.38074294
145VEGF signaling pathway_Homo sapiens_hsa043700.37346387
146Cholinergic synapse_Homo sapiens_hsa047250.37235949
147Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.37082983
148Longevity regulating pathway - mammal_Homo sapiens_hsa042110.36965272
149Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.35295666
150cGMP-PKG signaling pathway_Homo sapiens_hsa040220.34662492
151Arginine and proline metabolism_Homo sapiens_hsa003300.34393721
152Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.33492392
153Inositol phosphate metabolism_Homo sapiens_hsa005620.32724229
154Vascular smooth muscle contraction_Homo sapiens_hsa042700.31881563
155TNF signaling pathway_Homo sapiens_hsa046680.31761922
156Arginine biosynthesis_Homo sapiens_hsa002200.31648173
157Huntingtons disease_Homo sapiens_hsa050160.29120474
158Glycerophospholipid metabolism_Homo sapiens_hsa005640.28035028
159Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.25996130
160Collecting duct acid secretion_Homo sapiens_hsa049660.22640306
161Ether lipid metabolism_Homo sapiens_hsa005650.22213324
162Linoleic acid metabolism_Homo sapiens_hsa005910.21505596
163Viral carcinogenesis_Homo sapiens_hsa052030.18057554
164Glycosaminoglycan degradation_Homo sapiens_hsa005310.17962508

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