ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.27254795
2	response to pheromone (GO:0019236)	5.02056689
3	L-fucose catabolic process (GO:0042355)	4.71121277
4	fucose catabolic process (GO:0019317)	4.71121277
5	L-fucose metabolic process (GO:0042354)	4.71121277
6	indolalkylamine metabolic process (GO:0006586)	4.00791349
7	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	3.96689793
8	tryptophan metabolic process (GO:0006568)	3.85902054
9	water-soluble vitamin biosynthetic process (GO:0042364)	3.78562860
10	cellular ketone body metabolic process (GO:0046950)	3.76822211
11	primary amino compound metabolic process (GO:1901160)	3.75718783
12	DNA deamination (GO:0045006)	3.68746660
13	positive regulation of cAMP-mediated signaling (GO:0043950)	3.59844484
14	serotonin metabolic process (GO:0042428)	3.58217942
15	protein localization to cilium (GO:0061512)	3.55119107
16	cellular response to ATP (GO:0071318)	3.54317663
17	detection of light stimulus involved in sensory perception (GO:0050962)	3.45737771
18	detection of light stimulus involved in visual perception (GO:0050908)	3.45737771
19	ketone body metabolic process (GO:1902224)	3.44163468
20	somatic hypermutation of immunoglobulin genes (GO:0016446)	3.41881320
21	somatic diversification of immune receptors via somatic mutation (GO:0002566)	3.41881320
22	piRNA metabolic process (GO:0034587)	3.41116474
23	cytidine deamination (GO:0009972)	3.30896542
24	cytidine metabolic process (GO:0046087)	3.30896542
25	cytidine catabolic process (GO:0006216)	3.30896542
26	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.29249961
27	sulfation (GO:0051923)	3.26084645
28	negative regulation of systemic arterial blood pressure (GO:0003085)	3.22837936
29	neuronal action potential (GO:0019228)	3.19924424
30	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.19448035
31	NADH dehydrogenase complex assembly (GO:0010257)	3.19448035
32	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.19448035
33	tryptophan catabolic process (GO:0006569)	3.18728558
34	indole-containing compound catabolic process (GO:0042436)	3.18728558
35	indolalkylamine catabolic process (GO:0046218)	3.18728558
36	indole-containing compound metabolic process (GO:0042430)	3.17594942
37	positive regulation of cardiac muscle cell differentiation (GO:2000727)	3.12938845
38	nephron epithelium morphogenesis (GO:0072088)	3.12395201
39	nephron tubule morphogenesis (GO:0072078)	3.12395201
40	protein complex biogenesis (GO:0070271)	3.09762412
41	mitochondrial respiratory chain complex assembly (GO:0033108)	3.04783788
42	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.03155474
43	DNA methylation involved in gamete generation (GO:0043046)	3.02895399
44	tyrosine metabolic process (GO:0006570)	2.97812809
45	acrosome reaction (GO:0007340)	2.96662646
46	negative regulation of multicellular organism growth (GO:0040015)	2.92860399
47	reflex (GO:0060004)	2.90099989
48	positive regulation of digestive system process (GO:0060456)	2.86050862
49	glycerophospholipid catabolic process (GO:0046475)	2.83769150
50	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.83328875
51	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.82809023
52	kynurenine metabolic process (GO:0070189)	2.79224800
53	keratinocyte development (GO:0003334)	2.74744310
54	positive regulation of meiosis (GO:0045836)	2.69008043
55	regulation of action potential (GO:0098900)	2.68832228
56	opioid receptor signaling pathway (GO:0038003)	2.65781119
57	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.65072932
58	signal peptide processing (GO:0006465)	2.64432597
59	negative regulation of mast cell activation (GO:0033004)	2.63014121
60	transepithelial transport (GO:0070633)	2.62772590
61	spinal cord motor neuron differentiation (GO:0021522)	2.62443848
62	startle response (GO:0001964)	2.60444252
63	epithelial cilium movement (GO:0003351)	2.58918438
64	sphingoid metabolic process (GO:0046519)	2.58124556
65	preassembly of GPI anchor in ER membrane (GO:0016254)	2.57427295
66	sulfate transmembrane transport (GO:1902358)	2.56303988
67	positive regulation of heart rate (GO:0010460)	2.55799904
68	amine catabolic process (GO:0009310)	2.54980970
69	cellular biogenic amine catabolic process (GO:0042402)	2.54980970
70	regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003339	2.53769566
71	DNA demethylation (GO:0080111)	2.53308094
72	respiratory chain complex IV assembly (GO:0008535)	2.53224472
73	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	2.53028340
74	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	2.53028340
75	dopamine transport (GO:0015872)	2.50718442
76	multicellular organism reproduction (GO:0032504)	2.49413353
77	gamma-aminobutyric acid transport (GO:0015812)	2.49327533
78	urinary tract smooth muscle contraction (GO:0014848)	2.48047174
79	renal tubule morphogenesis (GO:0061333)	2.47536081
80	thyroid hormone metabolic process (GO:0042403)	2.47416231
81	positive regulation of meiotic cell cycle (GO:0051446)	2.47209022
82	positive regulation of fatty acid oxidation (GO:0046321)	2.46513649
83	male meiosis I (GO:0007141)	2.45670606
84	aromatic amino acid family metabolic process (GO:0009072)	2.45315064
85	mannosylation (GO:0097502)	2.44454862
86	regulation of neurotransmitter uptake (GO:0051580)	2.41687317
87	kidney morphogenesis (GO:0060993)	2.41611473
88	fusion of sperm to egg plasma membrane (GO:0007342)	2.41055014
89	platelet dense granule organization (GO:0060155)	2.39632501
90	aromatic amino acid family catabolic process (GO:0009074)	2.39053318
91	photoreceptor cell development (GO:0042461)	2.39007881
92	adrenergic receptor signaling pathway (GO:0071875)	2.38297016
93	activated T cell proliferation (GO:0050798)	2.37979092
94	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.37324202
95	sperm motility (GO:0030317)	2.36841528
96	cAMP catabolic process (GO:0006198)	2.36382240
97	cell proliferation in forebrain (GO:0021846)	2.36145807
98	cornea development in camera-type eye (GO:0061303)	2.35833294
99	GPI anchor metabolic process (GO:0006505)	2.35496610
100	replicative senescence (GO:0090399)	2.34223964

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	4.78499577
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.64037841
3	EZH2_22144423_ChIP-Seq_EOC_Human	3.29797428
4	VDR_22108803_ChIP-Seq_LS180_Human	3.29359767
5	GBX2_23144817_ChIP-Seq_PC3_Human	2.50256530
6	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.40286892
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.19157173
8	IGF1R_20145208_ChIP-Seq_DFB_Human	2.15620567
9	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.13363402
10	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.11427084
11	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.05214677
12	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.96114669
13	ER_23166858_ChIP-Seq_MCF-7_Human	1.92126672
14	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.89795292
15	FUS_26573619_Chip-Seq_HEK293_Human	1.88137566
16	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.86718718
17	P300_19829295_ChIP-Seq_ESCs_Human	1.84070628
18	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.68686959
19	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.67245233
20	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.65577682
21	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.65493693
22	TAF15_26573619_Chip-Seq_HEK293_Human	1.65444364
23	EWS_26573619_Chip-Seq_HEK293_Human	1.64798434
24	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.60363544
25	BCAT_22108803_ChIP-Seq_LS180_Human	1.59770545
26	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.55852059
27	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.49243874
28	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.47769047
29	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.47647536
30	SMAD4_21799915_ChIP-Seq_A2780_Human	1.45252381
31	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.43780107
32	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.43487018
33	STAT3_23295773_ChIP-Seq_U87_Human	1.43436030
34	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.42595281
35	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.42595281
36	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.42100835
37	AR_21572438_ChIP-Seq_LNCaP_Human	1.41678265
38	AR_25329375_ChIP-Seq_VCAP_Human	1.40953137
39	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.39178451
40	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.38721559
41	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.38714291
42	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.38403516
43	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.37681189
44	REST_21632747_ChIP-Seq_MESCs_Mouse	1.36653994
45	* SOX2_19829295_ChIP-Seq_ESCs_Human	1.36073251
46	* NANOG_19829295_ChIP-Seq_ESCs_Human	1.36073251
47	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.34520776
48	CBP_20019798_ChIP-Seq_JUKART_Human	1.34520776
49	TP53_22573176_ChIP-Seq_HFKS_Human	1.32588268
50	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.31937351
51	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.31816089
52	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.30428055
53	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.27376631
54	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.27348387
55	HOXB7_26014856_ChIP-Seq_BT474_Human	1.27346777
56	TCF4_23295773_ChIP-Seq_U87_Human	1.26730092
57	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.25614599
58	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.23883089
59	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.21998164
60	NCOR_22424771_ChIP-Seq_293T_Human	1.21047596
61	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.19324952
62	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.19324952
63	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.18544573
64	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.17632892
65	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.17600046
66	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.17331176
67	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.15813306
68	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.15557526
69	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.15149396
70	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.14814101
71	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.13461839
72	IRF1_19129219_ChIP-ChIP_H3396_Human	1.11388645
73	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.10537034
74	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.10520460
75	TCF4_22108803_ChIP-Seq_LS180_Human	1.09854946
76	RUNX2_22187159_ChIP-Seq_PCA_Human	1.07937194
77	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.06587156
78	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.04819115
79	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.04692285
80	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.02940010
81	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.02381648
82	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.01724198
83	* STAT3_18555785_Chip-Seq_ESCs_Mouse	0.99578388
84	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.98536927
85	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.98406267
86	CDX2_22108803_ChIP-Seq_LS180_Human	0.98395620
87	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.98329937
88	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.97922320
89	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.96965450
90	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.96117474
91	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	0.95791531
92	ERA_21632823_ChIP-Seq_H3396_Human	0.95567850
93	* CRX_20693478_ChIP-Seq_RETINA_Mouse	0.94650188
94	MYC_18940864_ChIP-ChIP_HL60_Human	0.94518845
95	MYC_19829295_ChIP-Seq_ESCs_Human	0.93731217
96	AR_20517297_ChIP-Seq_VCAP_Human	0.92578698
97	* CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.92014433
98	DROSHA_22980978_ChIP-Seq_HELA_Human	0.90979852
99	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.90877687
100	GABP_17652178_ChIP-ChIP_JURKAT_Human	0.90824386

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005171_absent_coat_pigmentation	3.75811786
2	MP0002837_dystrophic_cardiac_calcinosis	3.44267685
3	MP0002163_abnormal_gland_morphology	2.84613664
4	MP0002876_abnormal_thyroid_physiology	2.67748553
5	MP0001968_abnormal_touch/_nociception	2.65842634
6	MP0008877_abnormal_DNA_methylation	2.48803929
7	MP0000372_irregular_coat_pigmentation	2.46962667
8	MP0002102_abnormal_ear_morphology	2.46089259
9	MP0005379_endocrine/exocrine_gland_phen	2.28221875
10	MP0004142_abnormal_muscle_tone	2.26717548
11	MP0005410_abnormal_fertilization	2.21596662
12	MP0008872_abnormal_physiological_respon	2.18381329
13	MP0003195_calcinosis	2.12893061
14	MP0005551_abnormal_eye_electrophysiolog	2.08370765
15	MP0001986_abnormal_taste_sensitivity	2.06272090
16	MP0003787_abnormal_imprinting	2.04249513
17	MP0003646_muscle_fatigue	2.03762434
18	MP0000569_abnormal_digit_pigmentation	1.95197380
19	MP0000427_abnormal_hair_cycle	1.94677583
20	MP0009745_abnormal_behavioral_response	1.93348676
21	MP0009046_muscle_twitch	1.91723231
22	MP0003136_yellow_coat_color	1.89204840
23	MP0002736_abnormal_nociception_after	1.84485934
24	MP0002272_abnormal_nervous_system	1.83096436
25	MP0006072_abnormal_retinal_apoptosis	1.82021376
26	MP0005645_abnormal_hypothalamus_physiol	1.77287874
27	MP0004133_heterotaxia	1.72590313
28	MP0002735_abnormal_chemical_nociception	1.70838254
29	MP0005646_abnormal_pituitary_gland	1.67630820
30	MP0005084_abnormal_gallbladder_morpholo	1.63711605
31	MP0001486_abnormal_startle_reflex	1.56470256
32	MP0002138_abnormal_hepatobiliary_system	1.53011343
33	MP0002064_seizures	1.52869400
34	MP0002938_white_spotting	1.51919173
35	MP0005253_abnormal_eye_physiology	1.51869688
36	MP0005670_abnormal_white_adipose	1.50546881
37	MP0004885_abnormal_endolymph	1.48081872
38	MP0002638_abnormal_pupillary_reflex	1.47348200
39	MP0008875_abnormal_xenobiotic_pharmacok	1.44540772
40	MP0005083_abnormal_biliary_tract	1.43830928
41	MP0006292_abnormal_olfactory_placode	1.43749469
42	MP0003183_abnormal_peptide_metabolism	1.42426905
43	MP0002653_abnormal_ependyma_morphology	1.40475011
44	MP0001970_abnormal_pain_threshold	1.36229290
45	MP0003011_delayed_dark_adaptation	1.32132904
46	MP0002733_abnormal_thermal_nociception	1.28831620
47	MP0002928_abnormal_bile_duct	1.24495633
48	MP0001501_abnormal_sleep_pattern	1.24326737
49	MP0000631_abnormal_neuroendocrine_gland	1.19219718
50	MP0002160_abnormal_reproductive_system	1.15506512
51	MP0001905_abnormal_dopamine_level	1.15011531
52	MP0002572_abnormal_emotion/affect_behav	1.14038928
53	MP0001502_abnormal_circadian_rhythm	1.11197269
54	MP0001984_abnormal_olfaction	1.10811274
55	MP0005174_abnormal_tail_pigmentation	1.10300387
56	MP0002909_abnormal_adrenal_gland	1.09686580
57	MP0005389_reproductive_system_phenotype	1.09301575
58	MP0001485_abnormal_pinna_reflex	1.08323377
59	MP0002277_abnormal_respiratory_mucosa	1.08220697
60	MP0002693_abnormal_pancreas_physiology	1.06840545
61	MP0004145_abnormal_muscle_electrophysio	1.05439395
62	MP0004215_abnormal_myocardial_fiber	1.01308557
63	MP0001873_stomach_inflammation	0.98773743
64	MP0002067_abnormal_sensory_capabilities	0.98676535
65	MP0003698_abnormal_male_reproductive	0.97976014
66	MP0001440_abnormal_grooming_behavior	0.97651668
67	MP0002557_abnormal_social/conspecific_i	0.93734494
68	MP0005085_abnormal_gallbladder_physiolo	0.91816526
69	MP0005332_abnormal_amino_acid	0.91215500
70	MP0009697_abnormal_copulation	0.90721998
71	MP0005386_behavior/neurological_phenoty	0.89865934
72	MP0004924_abnormal_behavior	0.89865934
73	MP0002063_abnormal_learning/memory/cond	0.88289780
74	MP0006276_abnormal_autonomic_nervous	0.87291763
75	MP0001929_abnormal_gametogenesis	0.86593588
76	MP0005075_abnormal_melanosome_morpholog	0.86443166
77	MP0010386_abnormal_urinary_bladder	0.85398804
78	MP0005310_abnormal_salivary_gland	0.85179438
79	MP0003137_abnormal_impulse_conducting	0.84967831
80	MP0001944_abnormal_pancreas_morphology	0.84295276
81	MP0001529_abnormal_vocalization	0.83293503
82	MP0003880_abnormal_central_pattern	0.83179552
83	MP0005365_abnormal_bile_salt	0.81746113
84	MP0004043_abnormal_pH_regulation	0.81329960
85	MP0009764_decreased_sensitivity_to	0.80588830
86	MP0002229_neurodegeneration	0.80034974
87	MP0003635_abnormal_synaptic_transmissio	0.79142228
88	MP0002139_abnormal_hepatobiliary_system	0.78860126
89	MP0005448_abnormal_energy_balance	0.77545936
90	MP0002734_abnormal_mechanical_nocicepti	0.77417588
91	MP0005195_abnormal_posterior_eye	0.77287435
92	MP0003045_fibrosis	0.77189170
93	MP0004381_abnormal_hair_follicle	0.77083084
94	MP0005535_abnormal_body_temperature	0.76717146
95	MP0002254_reproductive_system_inflammat	0.76265144
96	MP0004742_abnormal_vestibular_system	0.76239395
97	MP0001765_abnormal_ion_homeostasis	0.75310318
98	MP0000230_abnormal_systemic_arterial	0.74182114
99	MP0003638_abnormal_response/metabolism_	0.72852401
100	MP0000026_abnormal_inner_ear	0.71809669

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Congenital stationary night blindness (HP:0007642)	3.95233617
2	Pancreatic cysts (HP:0001737)	3.85836088
3	Type II lissencephaly (HP:0007260)	3.83046746
4	Hypothermia (HP:0002045)	3.64500907
5	Nephronophthisis (HP:0000090)	3.56187895
6	Abnormality of the renal cortex (HP:0011035)	3.55950987
7	Pancreatic fibrosis (HP:0100732)	3.34887293
8	Tubular atrophy (HP:0000092)	3.32974300
9	Attenuation of retinal blood vessels (HP:0007843)	3.29245696
10	Abnormality of the renal medulla (HP:0100957)	3.20871867
11	Abnormal rod and cone electroretinograms (HP:0008323)	3.19645812
12	Abnormality of midbrain morphology (HP:0002418)	3.19233423
13	Molar tooth sign on MRI (HP:0002419)	3.19233423
14	True hermaphroditism (HP:0010459)	3.18440527
15	Pendular nystagmus (HP:0012043)	3.15844335
16	Chronic hepatic failure (HP:0100626)	3.03384941
17	Cerebellar dysplasia (HP:0007033)	2.97953118
18	Abolished electroretinogram (ERG) (HP:0000550)	2.92715772
19	Absent/shortened dynein arms (HP:0200106)	2.87184056
20	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.87184056
21	3-Methylglutaconic aciduria (HP:0003535)	2.75623105
22	Hyperventilation (HP:0002883)	2.70343478
23	Keratoconus (HP:0000563)	2.69614762
24	Increased corneal curvature (HP:0100692)	2.69614762
25	Gaze-evoked nystagmus (HP:0000640)	2.67398847
26	Abnormal drinking behavior (HP:0030082)	2.64613826
27	Polydipsia (HP:0001959)	2.64613826
28	Hypoplasia of the pons (HP:0012110)	2.62164179
29	Focal motor seizures (HP:0011153)	2.58376389
30	Abnormality of the pons (HP:0007361)	2.54473861
31	Lissencephaly (HP:0001339)	2.50578620
32	Bony spicule pigmentary retinopathy (HP:0007737)	2.48436597
33	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.45815434
34	Inability to walk (HP:0002540)	2.42860873
35	Genetic anticipation (HP:0003743)	2.42821216
36	Stomatitis (HP:0010280)	2.41142047
37	Abnormal respiratory epithelium morphology (HP:0012253)	2.31373696
38	Abnormal respiratory motile cilium morphology (HP:0005938)	2.31373696
39	Decreased central vision (HP:0007663)	2.29362346
40	Chorioretinal atrophy (HP:0000533)	2.24758620
41	Progressive cerebellar ataxia (HP:0002073)	2.22255498
42	Decreased circulating renin level (HP:0003351)	2.21604596
43	Cystic liver disease (HP:0006706)	2.19926208
44	Methylmalonic acidemia (HP:0002912)	2.19913914
45	Congenital sensorineural hearing impairment (HP:0008527)	2.18108805
46	Renal cortical cysts (HP:0000803)	2.18091071
47	Bile duct proliferation (HP:0001408)	2.17931369
48	Abnormal biliary tract physiology (HP:0012439)	2.17931369
49	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.15209944
50	Hemiparesis (HP:0001269)	2.14624503
51	Dialeptic seizures (HP:0011146)	2.14213826
52	Acute necrotizing encephalopathy (HP:0006965)	2.13121982
53	Ketoacidosis (HP:0001993)	2.12708504
54	Furrowed tongue (HP:0000221)	2.12569641
55	Severe muscular hypotonia (HP:0006829)	2.12509807
56	Mitochondrial inheritance (HP:0001427)	2.12140584
57	Medial flaring of the eyebrow (HP:0010747)	2.10899799
58	Abnormality of macular pigmentation (HP:0008002)	2.10533954
59	Asplenia (HP:0001746)	2.09425923
60	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.07488797
61	Large for gestational age (HP:0001520)	2.03775061
62	Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)	2.03622184
63	Short 4th metacarpal (HP:0010044)	2.03622184
64	Progressive inability to walk (HP:0002505)	2.03426724
65	Increased CSF lactate (HP:0002490)	2.02681185
66	Tachypnea (HP:0002789)	2.01160867
67	Progressive macrocephaly (HP:0004481)	2.00788081
68	Lipid accumulation in hepatocytes (HP:0006561)	1.94969297
69	Abnormality of alanine metabolism (HP:0010916)	1.93375292
70	Hyperalaninemia (HP:0003348)	1.93375292
71	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.93375292
72	Polyuria (HP:0000103)	1.92816669
73	Ketosis (HP:0001946)	1.92433561
74	Agitation (HP:0000713)	1.89714470
75	Methylmalonic aciduria (HP:0012120)	1.88147116
76	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.87509694
77	Abnormal albumin level (HP:0012116)	1.86141531
78	Hypoalbuminemia (HP:0003073)	1.86141531
79	Sclerocornea (HP:0000647)	1.85913941
80	Acute encephalopathy (HP:0006846)	1.85093296
81	Optic nerve hypoplasia (HP:0000609)	1.84926254
82	Volvulus (HP:0002580)	1.83618758
83	Severe visual impairment (HP:0001141)	1.83056463
84	Abnormal ciliary motility (HP:0012262)	1.81825771
85	Renal Fanconi syndrome (HP:0001994)	1.80871339
86	Congenital hepatic fibrosis (HP:0002612)	1.77671527
87	Pachygyria (HP:0001302)	1.75955778
88	Febrile seizures (HP:0002373)	1.75506014
89	Brushfield spots (HP:0001088)	1.75372759
90	Protruding tongue (HP:0010808)	1.74642069
91	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.74488265
92	Abnormality of homocysteine metabolism (HP:0010919)	1.74426559
93	Homocystinuria (HP:0002156)	1.74426559
94	Limb dystonia (HP:0002451)	1.73325250
95	Broad-based gait (HP:0002136)	1.73020487
96	Amelogenesis imperfecta (HP:0000705)	1.69882284
97	Optic disc pallor (HP:0000543)	1.69249490
98	Increased hepatocellular lipid droplets (HP:0006565)	1.68407386
99	Calf muscle hypertrophy (HP:0008981)	1.68361323
100	Abnormal mitochondria in muscle tissue (HP:0008316)	1.67091170

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.38135236
2	ADRBK2	4.15762586
3	ZAK	3.60875620
4	MAP4K2	3.16982850
5	TAOK3	3.10147900
6	CASK	2.58059898
7	GRK1	2.50213091
8	EPHA3	2.37496902
9	WNK4	2.29892114
10	TLK1	2.22105638
11	MAP2K6	2.18954103
12	PINK1	2.10826170
13	WNK3	2.08435732
14	NUAK1	2.08363260
15	STK38L	1.83276607
16	INSRR	1.82836237
17	LATS1	1.66735618
18	BMPR1B	1.64501209
19	NTRK3	1.64017926
20	STK39	1.58381716
21	OXSR1	1.52626219
22	TXK	1.48874001
23	TAF1	1.47927658
24	PAK3	1.38962841
25	TEC	1.38304279
26	PTK2B	1.36868885
27	EIF2AK3	1.31339391
28	ACVR1B	1.31246231
29	MAPK13	1.29541318
30	MAP3K4	1.29041513
31	PRKCG	1.26027134
32	DAPK2	1.20877444
33	VRK1	1.19598179
34	PRKCH	1.11943442
35	PHKG1	1.04747945
36	PHKG2	1.04747945
37	ADRBK1	1.04363275
38	PRKCI	1.01463051
39	PRKCE	0.99743006
40	CAMKK2	0.98612393
41	PIK3CG	0.97689722
42	MKNK2	0.96415758
43	TNIK	0.92106463
44	MST4	0.85654905
45	MAP2K7	0.84933677
46	PLK2	0.84872082
47	NME1	0.83944930
48	MAPK15	0.80096840
49	BCKDK	0.79616333
50	STK3	0.78261596
51	MAPKAPK5	0.76706828
52	BCR	0.76378390
53	FGFR2	0.76053974
54	STK11	0.69877148
55	DYRK2	0.69001209
56	IKBKB	0.68717714
57	ITK	0.68248496
58	RPS6KA5	0.67820872
59	TRIM28	0.67009610
60	GRK5	0.66998917
61	PNCK	0.65644447
62	PRKAA1	0.64340028
63	GRK7	0.62738014
64	MARK1	0.61814579
65	PRKCQ	0.59994019
66	NLK	0.58352576
67	PRKACA	0.55191586
68	PRKAA2	0.54578517
69	MUSK	0.54016736
70	CAMK2A	0.53052566
71	MAP3K2	0.50518930
72	BRSK2	0.50061623
73	PLK4	0.47602759
74	NTRK2	0.46392978
75	PLK3	0.46271800
76	CSNK1G2	0.45337966
77	WNK1	0.39571472
78	PRKCZ	0.39210662
79	TNK2	0.37493637
80	PRKCA	0.37223123
81	CSNK1A1L	0.36993773
82	MAP2K4	0.36682276
83	CSNK1A1	0.36180252
84	PRKG1	0.35743829
85	CSNK1G1	0.29891210
86	PIK3CA	0.29609469
87	CSNK1G3	0.29125446
88	PRKD2	0.28343936
89	PAK6	0.25117005
90	CDK3	0.24155659
91	PKN1	0.23983681
92	MAP2K1	0.23229694
93	CSNK1D	0.22155028
94	TIE1	0.21743762
95	STK38	0.21597956
96	PRKACB	0.20538281
97	CAMK1	0.20273104
98	OBSCN	0.19538804
99	PRKCB	0.19119844
100	TRPM7	0.17590614

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Maturity onset diabetes of the young_Homo sapiens_hsa04950	3.26894733
2	Phototransduction_Homo sapiens_hsa04744	2.77983187
3	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.73139083
4	Selenocompound metabolism_Homo sapiens_hsa00450	2.38026084
5	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.32682196
6	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.31663451
7	Nicotine addiction_Homo sapiens_hsa05033	2.26668145
8	Protein export_Homo sapiens_hsa03060	2.17265121
9	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.14683278
10	Oxidative phosphorylation_Homo sapiens_hsa00190	2.12184708
11	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.11814801
12	Linoleic acid metabolism_Homo sapiens_hsa00591	2.10884163
13	Nitrogen metabolism_Homo sapiens_hsa00910	2.04026946
14	Butanoate metabolism_Homo sapiens_hsa00650	2.03243619
15	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.00741015
16	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.97374994
17	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.84221463
18	Tryptophan metabolism_Homo sapiens_hsa00380	1.72735108
19	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.66276375
20	Taste transduction_Homo sapiens_hsa04742	1.61112650
21	Ether lipid metabolism_Homo sapiens_hsa00565	1.54239110
22	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.52035872
23	Homologous recombination_Homo sapiens_hsa03440	1.50762051
24	Basal transcription factors_Homo sapiens_hsa03022	1.47523214
25	Parkinsons disease_Homo sapiens_hsa05012	1.47514009
26	RNA polymerase_Homo sapiens_hsa03020	1.42690707
27	Insulin secretion_Homo sapiens_hsa04911	1.37346236
28	Olfactory transduction_Homo sapiens_hsa04740	1.31160574
29	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.26626471
30	Morphine addiction_Homo sapiens_hsa05032	1.25736367
31	Fanconi anemia pathway_Homo sapiens_hsa03460	1.25483282
32	Graft-versus-host disease_Homo sapiens_hsa05332	1.21976961
33	Cardiac muscle contraction_Homo sapiens_hsa04260	1.20843330
34	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.19190014
35	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.19189534
36	Peroxisome_Homo sapiens_hsa04146	1.14098700
37	Type I diabetes mellitus_Homo sapiens_hsa04940	1.13309064
38	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.11726782
39	Regulation of autophagy_Homo sapiens_hsa04140	1.11707760
40	One carbon pool by folate_Homo sapiens_hsa00670	1.10976322
41	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.03596569
42	Primary immunodeficiency_Homo sapiens_hsa05340	1.03420616
43	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.02335530
44	Alzheimers disease_Homo sapiens_hsa05010	1.00771241
45	Salivary secretion_Homo sapiens_hsa04970	1.00752450
46	Sulfur metabolism_Homo sapiens_hsa00920	0.99079341
47	Huntingtons disease_Homo sapiens_hsa05016	0.97412215
48	Circadian entrainment_Homo sapiens_hsa04713	0.93640066
49	Chemical carcinogenesis_Homo sapiens_hsa05204	0.92272666
50	Sulfur relay system_Homo sapiens_hsa04122	0.91532498
51	Collecting duct acid secretion_Homo sapiens_hsa04966	0.89232231
52	Mineral absorption_Homo sapiens_hsa04978	0.88605432
53	Circadian rhythm_Homo sapiens_hsa04710	0.87818384
54	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.84570730
55	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.83523148
56	GABAergic synapse_Homo sapiens_hsa04727	0.82728422
57	Glutamatergic synapse_Homo sapiens_hsa04724	0.82512111
58	Calcium signaling pathway_Homo sapiens_hsa04020	0.82197315
59	ABC transporters_Homo sapiens_hsa02010	0.81991295
60	Alcoholism_Homo sapiens_hsa05034	0.79174971
61	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.75563996
62	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.75422986
63	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.75297811
64	Serotonergic synapse_Homo sapiens_hsa04726	0.73805701
65	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.71973607
66	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.71355831
67	Caffeine metabolism_Homo sapiens_hsa00232	0.71313029
68	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.70292203
69	beta-Alanine metabolism_Homo sapiens_hsa00410	0.70011548
70	Sphingolipid metabolism_Homo sapiens_hsa00600	0.69296608
71	RNA degradation_Homo sapiens_hsa03018	0.69073690
72	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.67755046
73	cAMP signaling pathway_Homo sapiens_hsa04024	0.64246900
74	Fatty acid degradation_Homo sapiens_hsa00071	0.63608060
75	Propanoate metabolism_Homo sapiens_hsa00640	0.62369487
76	Allograft rejection_Homo sapiens_hsa05330	0.61068686
77	Asthma_Homo sapiens_hsa05310	0.59603163
78	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.57388021
79	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.57292318
80	Fat digestion and absorption_Homo sapiens_hsa04975	0.53833704
81	Glycerolipid metabolism_Homo sapiens_hsa00561	0.53131071
82	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.52084173
83	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.51693833
84	Histidine metabolism_Homo sapiens_hsa00340	0.50702501
85	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.49960211
86	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.49922965
87	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.49750626
88	Renin secretion_Homo sapiens_hsa04924	0.49474567
89	Metabolic pathways_Homo sapiens_hsa01100	0.49168737
90	Retinol metabolism_Homo sapiens_hsa00830	0.48986927
91	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.47634259
92	Purine metabolism_Homo sapiens_hsa00230	0.42360398
93	Fatty acid metabolism_Homo sapiens_hsa01212	0.41059876
94	Type II diabetes mellitus_Homo sapiens_hsa04930	0.39145675
95	Basal cell carcinoma_Homo sapiens_hsa05217	0.38986217
96	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.38617819
97	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.37116734
98	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.36640964
99	Steroid biosynthesis_Homo sapiens_hsa00100	0.35816261
100	Non-homologous end-joining_Homo sapiens_hsa03450	0.34393686

TEDDM1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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