TEF

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the PAR (proline and acidic amino acid-rich) subfamily of basic region/leucine zipper (bZIP) transcription factors. It is expressed in a broad range of cells and tissues in adult animals, however, during embryonic development, TEF expression appears to be restricted to the developing anterior pituitary gland, coincident with the appearance of thyroid-stimulating hormone, beta (TSHB). Indeed, TEF can bind to, and transactivate the TSHB promoter. It shows homology (in the functional domains) with other members of the PAR-bZIP subfamily of transcription factors, which include albumin D box-binding protein (DBP), human hepatic leukemia factor (HLF) and chicken vitellogenin gene-binding protein (VBP); VBP is considered the chicken homologue of TEF. Different members of the subfamily can readily form heterodimers, and share DNA-binding, and transcriptional regulatory properties. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cerebellar granule cell differentiation (GO:0021707)4.56188053
2locomotory exploration behavior (GO:0035641)4.49974290
3synaptic vesicle maturation (GO:0016188)4.36008898
4regulation of short-term neuronal synaptic plasticity (GO:0048172)4.34860689
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.21982268
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.01604439
7vocalization behavior (GO:0071625)3.79274491
8amino acid import (GO:0043090)3.76246025
9glutamate secretion (GO:0014047)3.75929421
10cytoskeletal anchoring at plasma membrane (GO:0007016)3.74703492
11regulation of synapse maturation (GO:0090128)3.74038269
12regulation of synapse structural plasticity (GO:0051823)3.62640673
13membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.61409567
14regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.59895423
15synaptic vesicle docking involved in exocytosis (GO:0016081)3.58362269
16neurotransmitter-gated ion channel clustering (GO:0072578)3.56601169
17synaptic vesicle exocytosis (GO:0016079)3.55177629
18regulation of glutamate receptor signaling pathway (GO:1900449)3.54838179
19sodium ion export (GO:0071436)3.52754354
20cellular potassium ion homeostasis (GO:0030007)3.48699020
21neurotransmitter secretion (GO:0007269)3.39200353
22neuronal action potential propagation (GO:0019227)3.35721703
23regulation of neuronal synaptic plasticity (GO:0048168)3.33002512
24gamma-aminobutyric acid transport (GO:0015812)3.32511356
25regulation of synaptic vesicle exocytosis (GO:2000300)3.31899040
26cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.29663684
27central nervous system myelination (GO:0022010)3.29496864
28axon ensheathment in central nervous system (GO:0032291)3.29496864
29positive regulation of dendritic spine development (GO:0060999)3.26373528
30regulation of long-term neuronal synaptic plasticity (GO:0048169)3.23862659
31ionotropic glutamate receptor signaling pathway (GO:0035235)3.15342071
32activation of protein kinase A activity (GO:0034199)3.12643071
33layer formation in cerebral cortex (GO:0021819)3.11967976
34synaptic vesicle endocytosis (GO:0048488)3.06151509
35regulation of synaptic vesicle transport (GO:1902803)3.05262058
36exploration behavior (GO:0035640)3.05025365
37postsynaptic membrane organization (GO:0001941)3.04415153
38positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.02392598
39cell communication by electrical coupling (GO:0010644)3.02028504
40prepulse inhibition (GO:0060134)2.98045496
41dicarboxylic acid biosynthetic process (GO:0043650)2.93846509
42long-term memory (GO:0007616)2.93692870
43regulation of vesicle fusion (GO:0031338)2.91429366
44glutamate receptor signaling pathway (GO:0007215)2.91124026
45protein localization to synapse (GO:0035418)2.90881214
46neuromuscular process controlling balance (GO:0050885)2.90853100
47regulation of dendritic spine morphogenesis (GO:0061001)2.88881489
48regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.87612401
49potassium ion import (GO:0010107)2.87534879
50negative regulation of dendrite morphogenesis (GO:0050774)2.86542292
51dendritic spine morphogenesis (GO:0060997)2.86383041
52positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.85908162
53cellular sodium ion homeostasis (GO:0006883)2.85169492
54synaptic transmission, glutamatergic (GO:0035249)2.85139335
55glycine transport (GO:0015816)2.81335975
56negative regulation of synaptic transmission, GABAergic (GO:0032229)2.80444894
57regulation of excitatory postsynaptic membrane potential (GO:0060079)2.80411906
58regulation of cell communication by electrical coupling (GO:0010649)2.74939865
59negative regulation of cytosolic calcium ion concentration (GO:0051481)2.74264772
60neuron-neuron synaptic transmission (GO:0007270)2.73436998
61chemosensory behavior (GO:0007635)2.72657947
62proline transport (GO:0015824)2.71836091
63detection of calcium ion (GO:0005513)2.70103112
64regulation of neurotransmitter transport (GO:0051588)2.69129377
65neurotransmitter transport (GO:0006836)2.67575405
66membrane depolarization during action potential (GO:0086010)2.67129343
67acidic amino acid transport (GO:0015800)2.65809407
68positive regulation of membrane potential (GO:0045838)2.65312948
69creatine metabolic process (GO:0006600)2.65066003
70alanine transport (GO:0032328)2.64587219
71regulation of postsynaptic membrane potential (GO:0060078)2.61654302
72glutamate metabolic process (GO:0006536)2.61589084
73striatum development (GO:0021756)2.61028741
74positive regulation of dendrite development (GO:1900006)2.60717975
75sarcoplasmic reticulum calcium ion transport (GO:0070296)2.60455451
76positive regulation of neurotransmitter secretion (GO:0001956)2.60225325
77regulation of synaptic transmission, glutamatergic (GO:0051966)2.59878355
78regulation of neurotransmitter levels (GO:0001505)2.58894360
79cell communication involved in cardiac conduction (GO:0086065)2.58869272
80regulation of synaptic plasticity (GO:0048167)2.58634591
81regulation of ARF protein signal transduction (GO:0032012)2.56960499
82neuromuscular process controlling posture (GO:0050884)2.56564722
83dendritic spine organization (GO:0097061)2.55880175
84behavioral response to cocaine (GO:0048148)2.53893374
85neurotransmitter uptake (GO:0001504)2.53271381
86neuromuscular synaptic transmission (GO:0007274)2.53044458
87gamma-aminobutyric acid signaling pathway (GO:0007214)2.52590428
88G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.52553747
89cerebellar Purkinje cell layer development (GO:0021680)2.51083610
90positive regulation of synapse maturation (GO:0090129)2.50701814
91erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.50580149
92L-phenylalanine catabolic process (GO:0006559)2.50580149
93regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.50344832
94regulation of sodium ion transmembrane transporter activity (GO:2000649)2.49589738
95regulation of sodium ion transmembrane transport (GO:1902305)2.49541413
96alpha-linolenic acid metabolic process (GO:0036109)2.48559068
97negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.48455089
98sodium ion homeostasis (GO:0055078)2.48249985
99regulation of female receptivity (GO:0045924)2.48137284
100auditory behavior (GO:0031223)2.46637932
101regulation of synaptic transmission (GO:0050804)2.46302186
102cerebellar Purkinje cell differentiation (GO:0021702)2.46222522
103cardiac muscle contraction (GO:0060048)2.45018790
104lysine catabolic process (GO:0006554)2.44336605
105lysine metabolic process (GO:0006553)2.44336605
106regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.43331017
107NADH metabolic process (GO:0006734)2.42892850
108dicarboxylic acid catabolic process (GO:0043649)2.42077942
109potassium ion homeostasis (GO:0055075)2.42009850
110dendrite morphogenesis (GO:0048813)2.41753024
111dicarboxylic acid transport (GO:0006835)2.41298633
112mating behavior (GO:0007617)2.40844228
113neuronal ion channel clustering (GO:0045161)2.40278072
114transmission of nerve impulse (GO:0019226)2.40164263
115membrane depolarization (GO:0051899)2.38514934
116long-term synaptic potentiation (GO:0060291)2.38183341
117L-amino acid import (GO:0043092)2.38086645
118positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.37826276
119regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.36363906
120positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.36220245
121regulation of dendritic spine development (GO:0060998)2.34167479
122L-phenylalanine metabolic process (GO:0006558)2.32565939
123erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.32565939
124membrane hyperpolarization (GO:0060081)2.32328655
125regulation of voltage-gated calcium channel activity (GO:1901385)2.32313396
126positive regulation of synaptic transmission, GABAergic (GO:0032230)2.31611215
127regulation of membrane repolarization (GO:0060306)2.30911240
128response to auditory stimulus (GO:0010996)2.30252490
129aspartate family amino acid catabolic process (GO:0009068)2.29499899
130G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.28471953
131positive regulation of neurotransmitter transport (GO:0051590)2.27333826
132long term synaptic depression (GO:0060292)2.27176335
133regulation of neurotransmitter secretion (GO:0046928)2.26454385
134regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.26321034

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.89453289
2SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.56493562
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.49746480
4DROSHA_22980978_ChIP-Seq_HELA_Human2.49022548
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.46441580
6* RARB_27405468_Chip-Seq_BRAIN_Mouse2.44658118
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.30615822
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.30615822
9MTF2_20144788_ChIP-Seq_MESCs_Mouse2.23745487
10GBX2_23144817_ChIP-Seq_PC3_Human2.21812468
11JARID2_20064375_ChIP-Seq_MESCs_Mouse2.20239621
12SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.18182533
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.12930018
14MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.09154534
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.06566442
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.04262716
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.97642330
18REST_21632747_ChIP-Seq_MESCs_Mouse1.95098652
19RXR_22158963_ChIP-Seq_LIVER_Mouse1.89342415
20EZH2_27294783_Chip-Seq_ESCs_Mouse1.88792559
21SUZ12_27294783_Chip-Seq_ESCs_Mouse1.87071181
22EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.85210040
23EZH2_27304074_Chip-Seq_ESCs_Mouse1.76681175
24EED_16625203_ChIP-ChIP_MESCs_Mouse1.72995765
25LXR_22158963_ChIP-Seq_LIVER_Mouse1.72717035
26PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.71110903
27RNF2_27304074_Chip-Seq_ESCs_Mouse1.69878150
28* REST_18959480_ChIP-ChIP_MESCs_Mouse1.69295730
29ERG_21242973_ChIP-ChIP_JURKAT_Human1.68650456
30NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.68403096
31AR_21572438_ChIP-Seq_LNCaP_Human1.60160687
32IKZF1_21737484_ChIP-ChIP_HCT116_Human1.58158662
33TRIM28_21343339_ChIP-Seq_HEK293_Human1.54920226
34RARG_19884340_ChIP-ChIP_MEFs_Mouse1.52270983
35* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.51640102
36FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.49144737
37PPARA_22158963_ChIP-Seq_LIVER_Mouse1.46586232
38PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.46410658
39THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.43131957
40TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.42117141
41ZFP281_27345836_Chip-Seq_ESCs_Mouse1.40301714
42ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.38276757
43DNAJC2_21179169_ChIP-ChIP_NT2_Human1.37615426
44RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.36927949
45ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.30888221
46KDM2B_26808549_Chip-Seq_K562_Human1.29258236
47WT1_25993318_ChIP-Seq_PODOCYTE_Human1.26679317
48PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.24769211
49ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.23267103
50GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.23139291
51ESR1_21235772_ChIP-Seq_MCF-7_Human1.22514285
52PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.21849140
53* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.19483642
54SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.19394999
55EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.19376743
56ESR1_20079471_ChIP-ChIP_T-47D_Human1.19250063
57SMAD4_21799915_ChIP-Seq_A2780_Human1.18279404
58* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.16573375
59CREB1_26743006_Chip-Seq_LNCaP_Human1.16356216
60NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.15409652
61ZNF217_24962896_ChIP-Seq_MCF-7_Human1.15136209
62CDX2_19796622_ChIP-Seq_MESCs_Mouse1.14918859
63* KDM2B_26808549_Chip-Seq_DND41_Human1.14682287
64SOX2_21211035_ChIP-Seq_LN229_Gbm1.14622614
65* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.14254372
66EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.13588083
67ESR2_21235772_ChIP-Seq_MCF-7_Human1.13535538
68RACK7_27058665_Chip-Seq_MCF-7_Human1.12402240
69* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.11565777
70CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.10928228
71RING1B_27294783_Chip-Seq_ESCs_Mouse1.10774564
72AR_19668381_ChIP-Seq_PC3_Human1.10611166
73NR3C1_23031785_ChIP-Seq_PC12_Mouse1.09754426
74GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09151285
75* FOXA2_19822575_ChIP-Seq_HepG2_Human1.08045848
76CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.07728415
77EP300_21415370_ChIP-Seq_HL-1_Mouse1.07231026
78TBX20_22080862_ChIP-Seq_HEART_Mouse1.06902117
79TBX20_22328084_ChIP-Seq_HEART_Mouse1.06902117
80SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.05536714
81CTNNB1_20460455_ChIP-Seq_HCT116_Human1.03536404
82OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.02045708
83UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.01993413
84RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.01822796
85CTCF_27219007_Chip-Seq_Bcells_Human1.01454674
86CTBP1_25329375_ChIP-Seq_LNCAP_Human1.00417428
87PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.00261516
88P68_20966046_ChIP-Seq_HELA_Human0.99954327
89TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.99422088
90CTBP2_25329375_ChIP-Seq_LNCAP_Human0.98773613
91SMAD3_21741376_ChIP-Seq_HESCs_Human0.98763710
92ZFP281_18757296_ChIP-ChIP_E14_Mouse0.98533498
93SMAD4_21741376_ChIP-Seq_HESCs_Human0.98096385
94AHR_22903824_ChIP-Seq_MCF-7_Human0.97154462
95CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.96030156
96PIAS1_25552417_ChIP-Seq_VCAP_Human0.95771755
97RXR_22108803_ChIP-Seq_LS180_Human0.94644586
98SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94415886
99STAT3_23295773_ChIP-Seq_U87_Human0.93883782
100ARNT_22903824_ChIP-Seq_MCF-7_Human0.93484111
101NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.92821012
102OCT4_19829295_ChIP-Seq_ESCs_Human0.92754307
103* CLOCK_20551151_ChIP-Seq_293T_Human0.92434975
104KDM2B_26808549_Chip-Seq_JURKAT_Human0.91064850
105AR_25329375_ChIP-Seq_VCAP_Human0.90739456
106* TP53_23651856_ChIP-Seq_MEFs_Mouse0.90518410
107* TP53_20018659_ChIP-ChIP_R1E_Mouse0.90346674
108SMAD3_21741376_ChIP-Seq_EPCs_Human0.87945071
109KDM2B_26808549_Chip-Seq_SUP-B15_Human0.87572974
110TP53_16413492_ChIP-PET_HCT116_Human0.87414003
111* LXR_22292898_ChIP-Seq_THP-1_Human0.86509077
112* TCF7_22412390_ChIP-Seq_EML_Mouse0.86378373
113KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.85945235
114NFIB_24661679_ChIP-Seq_LUNG_Mouse0.85890791
115BCAT_22108803_ChIP-Seq_LS180_Human0.85841458
116RING1B_27294783_Chip-Seq_NPCs_Mouse0.85657734
117* KLF4_19829295_ChIP-Seq_ESCs_Human0.85565957
118NR3C1_21868756_ChIP-Seq_MCF10A_Human0.85046934
119NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.84400538
120SA1_27219007_Chip-Seq_ERYTHROID_Human0.84286208
121PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.84082997
122SRY_22984422_ChIP-ChIP_TESTIS_Rat0.83697137
123TAF15_26573619_Chip-Seq_HEK293_Human0.83526562
124TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.83182521
125ZNF274_21170338_ChIP-Seq_K562_Hela0.82909053
126CTCF_27219007_Chip-Seq_ERYTHROID_Human0.82434893
127RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.81683258
128AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.81454766
129P53_22127205_ChIP-Seq_FIBROBLAST_Human0.80882261
130MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.80877448
131SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.80525026
132SMAD4_21741376_ChIP-Seq_EPCs_Human0.80203190
133* TET1_21490601_ChIP-Seq_MESCs_Mouse0.79559809
134ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.78516851
135SMC4_20622854_ChIP-Seq_HELA_Human0.78036935
136* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.77759766

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.50525221
2MP0002822_catalepsy4.03996755
3MP0003635_abnormal_synaptic_transmissio3.27725765
4MP0003880_abnormal_central_pattern2.88732517
5MP0004270_analgesia2.82478764
6MP0009745_abnormal_behavioral_response2.76382221
7MP0002139_abnormal_hepatobiliary_system2.63305780
8MP0005360_urolithiasis2.58989273
9MP0002063_abnormal_learning/memory/cond2.56200993
10* MP0002064_seizures2.41186740
11MP0009046_muscle_twitch2.37254688
12MP0005085_abnormal_gallbladder_physiolo2.22983530
13MP0009780_abnormal_chondrocyte_physiolo2.05485851
14MP0002572_abnormal_emotion/affect_behav2.04273850
15MP0001486_abnormal_startle_reflex2.02948556
16MP0002272_abnormal_nervous_system2.00781008
17MP0003329_amyloid_beta_deposits1.99456852
18MP0002837_dystrophic_cardiac_calcinosis1.98882663
19MP0000751_myopathy1.97331220
20MP0005365_abnormal_bile_salt1.93576881
21MP0002909_abnormal_adrenal_gland1.90267503
22MP0001501_abnormal_sleep_pattern1.90089983
23MP0008875_abnormal_xenobiotic_pharmacok1.88686366
24MP0004130_abnormal_muscle_cell1.86578573
25MP0001968_abnormal_touch/_nociception1.80084114
26MP0005423_abnormal_somatic_nervous1.73504785
27MP0002734_abnormal_mechanical_nocicepti1.72108775
28MP0008569_lethality_at_weaning1.68641911
29MP0010329_abnormal_lipoprotein_level1.64469536
30MP0001440_abnormal_grooming_behavior1.57016855
31MP0003690_abnormal_glial_cell1.51698317
32MP0004885_abnormal_endolymph1.48528457
33MP0004145_abnormal_muscle_electrophysio1.46099570
34MP0004858_abnormal_nervous_system1.41833862
35MP0003633_abnormal_nervous_system1.41007689
36MP0005646_abnormal_pituitary_gland1.39021680
37MP0003252_abnormal_bile_duct1.38836406
38MP0008961_abnormal_basal_metabolism1.38536592
39MP0005409_darkened_coat_color1.35939527
40MP0003075_altered_response_to1.35578134
41MP0002067_abnormal_sensory_capabilities1.34344196
42MP0005167_abnormal_blood-brain_barrier1.31739473
43MP0004043_abnormal_pH_regulation1.31438018
44MP0005386_behavior/neurological_phenoty1.31201616
45MP0004924_abnormal_behavior1.31201616
46MP0003646_muscle_fatigue1.30241159
47MP0000013_abnormal_adipose_tissue1.28326832
48MP0003879_abnormal_hair_cell1.27802429
49MP0005535_abnormal_body_temperature1.27676715
50MP0004215_abnormal_myocardial_fiber1.25122374
51MP0002090_abnormal_vision1.23526762
52MP0004036_abnormal_muscle_relaxation1.22401338
53MP0003634_abnormal_glial_cell1.21520531
54MP0001984_abnormal_olfaction1.21225317
55MP0005332_abnormal_amino_acid1.18963913
56MP0002733_abnormal_thermal_nociception1.18911465
57MP0001502_abnormal_circadian_rhythm1.18831075
58MP0001970_abnormal_pain_threshold1.17751868
59MP0002736_abnormal_nociception_after1.17225922
60MP0000604_amyloidosis1.16582773
61MP0008874_decreased_physiological_sensi1.15551768
62MP0004811_abnormal_neuron_physiology1.13833496
63MP0002557_abnormal_social/conspecific_i1.13409510
64MP0000747_muscle_weakness1.12025607
65MP0002118_abnormal_lipid_homeostasis1.11367749
66MP0003123_paternal_imprinting1.10769633
67MP0002066_abnormal_motor_capabilities/c1.09021353
68MP0010234_abnormal_vibrissa_follicle1.08278013
69MP0003631_nervous_system_phenotype1.07375117
70MP0000759_abnormal_skeletal_muscle1.07056370
71MP0008872_abnormal_physiological_respon1.04104538
72MP0000566_synostosis1.03975040
73MP0003195_calcinosis1.01628829
74MP0005620_abnormal_muscle_contractility0.99441061
75MP0002735_abnormal_chemical_nociception0.99083232
76MP0000749_muscle_degeneration0.98861035
77MP0004085_abnormal_heartbeat0.98211977
78MP0000955_abnormal_spinal_cord0.98108056
79MP0005584_abnormal_enzyme/coenzyme_acti0.97057729
80MP0005551_abnormal_eye_electrophysiolog0.96132410
81MP0002184_abnormal_innervation0.95408187
82MP0001348_abnormal_lacrimal_gland0.95011940
83MP0001177_atelectasis0.94319598
84MP0005670_abnormal_white_adipose0.93257907
85MP0002069_abnormal_eating/drinking_beha0.89812929
86MP0002882_abnormal_neuron_morphology0.89431987
87MP0003632_abnormal_nervous_system0.88021690
88MP0005083_abnormal_biliary_tract0.87744286
89MP0004510_myositis0.87605519
90MP0002269_muscular_atrophy0.87456981
91MP0002249_abnormal_larynx_morphology0.87148812
92MP0002106_abnormal_muscle_physiology0.86667223
93MP0004087_abnormal_muscle_fiber0.86452604
94MP0005666_abnormal_adipose_tissue0.85503295
95MP0003137_abnormal_impulse_conducting0.85164924
96MP0005375_adipose_tissue_phenotype0.84154494
97MP0000579_abnormal_nail_morphology0.82489637
98MP0002229_neurodegeneration0.81782760
99MP0003191_abnormal_cellular_cholesterol0.81181561
100MP0001346_abnormal_lacrimal_gland0.80994842
101MP0005369_muscle_phenotype0.79455121
102MP0000920_abnormal_myelination0.78449130
103MP0001963_abnormal_hearing_physiology0.77131915
104MP0005623_abnormal_meninges_morphology0.77023230
105MP0000778_abnormal_nervous_system0.76435968
106MP0001666_abnormal_nutrient_absorption0.76411700
107MP0001299_abnormal_eye_distance/0.76213174
108MP0002971_abnormal_brown_adipose0.76098174
109MP0004084_abnormal_cardiac_muscle0.75699433
110MP0004233_abnormal_muscle_weight0.75636176
111MP0003787_abnormal_imprinting0.75294026
112MP0009840_abnormal_foam_cell0.75201562
113MP0001765_abnormal_ion_homeostasis0.75073019
114MP0003705_abnormal_hypodermis_morpholog0.75009952
115MP0002152_abnormal_brain_morphology0.74817648
116MP0003283_abnormal_digestive_organ0.74717342
117MP0004142_abnormal_muscle_tone0.73964145
118MP0002078_abnormal_glucose_homeostasis0.73819726
119MP0005330_cardiomyopathy0.73592502
120MP0006276_abnormal_autonomic_nervous0.73064923
121MP0005166_decreased_susceptibility_to0.70546026
122MP0002876_abnormal_thyroid_physiology0.70375147
123MP0001958_emphysema0.68340135
124MP0004742_abnormal_vestibular_system0.67923505
125MP0003045_fibrosis0.67420500
126MP0001485_abnormal_pinna_reflex0.67145321
127MP0000003_abnormal_adipose_tissue0.66685444
128MP0002332_abnormal_exercise_endurance0.65419051
129MP0006138_congestive_heart_failure0.65418750
130MP0002089_abnormal_postnatal_growth/wei0.63926698

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.41003781
2Focal motor seizures (HP:0011153)5.21791524
3Obstructive sleep apnea (HP:0002870)4.08943017
4Focal seizures (HP:0007359)4.03235270
5Visual hallucinations (HP:0002367)3.65185793
6Diplopia (HP:0000651)3.61045644
7Abnormality of binocular vision (HP:0011514)3.61045644
8Action tremor (HP:0002345)3.58500494
9Exercise-induced myalgia (HP:0003738)3.50244845
10Muscle fiber inclusion bodies (HP:0100299)3.27982382
11Type 1 muscle fiber predominance (HP:0003803)3.23898777
12Nemaline bodies (HP:0003798)3.19858980
13Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.11002188
14Generalized tonic-clonic seizures (HP:0002069)2.95894585
15Dysdiadochokinesis (HP:0002075)2.91847754
16Impaired social interactions (HP:0000735)2.86249380
17Abnormal social behavior (HP:0012433)2.86249380
18Deep venous thrombosis (HP:0002625)2.85664002
19Dysmetric saccades (HP:0000641)2.83654278
20Impaired vibration sensation in the lower limbs (HP:0002166)2.81190731
21Abnormality of the lower motor neuron (HP:0002366)2.79407989
22Poor eye contact (HP:0000817)2.78086581
23Epileptic encephalopathy (HP:0200134)2.75712486
24Postural instability (HP:0002172)2.75512375
25Muscle fiber splitting (HP:0003555)2.74016441
26Torticollis (HP:0000473)2.73930364
27Depression (HP:0000716)2.73059874
28Papilledema (HP:0001085)2.70389698
29Absence seizures (HP:0002121)2.69932191
30Intention tremor (HP:0002080)2.69904750
31Status epilepticus (HP:0002133)2.68427742
32Progressive cerebellar ataxia (HP:0002073)2.61860927
33Bundle branch block (HP:0011710)2.61575439
34Anxiety (HP:0000739)2.60870847
35Ketosis (HP:0001946)2.59046154
36Atonic seizures (HP:0010819)2.57589054
37Febrile seizures (HP:0002373)2.55351926
38Dysmetria (HP:0001310)2.55125961
39Ankle clonus (HP:0011448)2.53381341
40Supranuclear gaze palsy (HP:0000605)2.53064799
41Ventricular fibrillation (HP:0001663)2.51214402
42Ketoacidosis (HP:0001993)2.49403890
43Focal dystonia (HP:0004373)2.46471216
44Neuronal loss in central nervous system (HP:0002529)2.46045748
45Xanthomatosis (HP:0000991)2.44688874
46Difficulty running (HP:0009046)2.43663230
47Myoglobinuria (HP:0002913)2.43273880
48Myopathic facies (HP:0002058)2.42650677
49Dialeptic seizures (HP:0011146)2.42499623
50Gaze-evoked nystagmus (HP:0000640)2.41964766
51Gout (HP:0001997)2.41653289
52Scanning speech (HP:0002168)2.40745651
53Neurofibrillary tangles (HP:0002185)2.40378861
54Resting tremor (HP:0002322)2.38536486
55Sudden death (HP:0001699)2.38427448
56Urinary bladder sphincter dysfunction (HP:0002839)2.37711864
57Rapidly progressive (HP:0003678)2.35184240
58Craniofacial dystonia (HP:0012179)2.35104737
59Exercise-induced muscle cramps (HP:0003710)2.34962749
60Hemiplegia (HP:0002301)2.34566768
61Hyperventilation (HP:0002883)2.33486147
62Centrally nucleated skeletal muscle fibers (HP:0003687)2.33034912
63Urinary urgency (HP:0000012)2.32536802
64Broad-based gait (HP:0002136)2.32335824
65Abnormality of skeletal muscle fiber size (HP:0012084)2.32195669
66EMG: myopathic abnormalities (HP:0003458)2.31297858
67Hyperlipoproteinemia (HP:0010980)2.30025812
68Mutism (HP:0002300)2.30018117
69Cerebral inclusion bodies (HP:0100314)2.29907609
70Sleep apnea (HP:0010535)2.27687565
71Akinesia (HP:0002304)2.27548065
72Rigidity (HP:0002063)2.25610336
73Distal lower limb muscle weakness (HP:0009053)2.24928072
74Aplasia involving bones of the extremities (HP:0009825)2.23545453
75Aplasia involving bones of the upper limbs (HP:0009823)2.23545453
76Aplasia of the phalanges of the hand (HP:0009802)2.23545453
77Foot dorsiflexor weakness (HP:0009027)2.21028203
78Insomnia (HP:0100785)2.19095361
79Abnormal eating behavior (HP:0100738)2.16054253
80Atrioventricular block (HP:0001678)2.15540641
81Heart block (HP:0012722)2.15339912
82Abnormality of aromatic amino acid family metabolism (HP:0004338)2.14391980
83Complement deficiency (HP:0004431)2.09609705
84Prolonged QT interval (HP:0001657)2.08989245
85Hyporeflexia of lower limbs (HP:0002600)2.08794454
86Clonus (HP:0002169)2.08127609
87Impaired vibratory sensation (HP:0002495)2.07780075
88Abnormality of the Achilles tendon (HP:0005109)2.07416204
89Turricephaly (HP:0000262)2.07036570
90Abnormality of the foot musculature (HP:0001436)2.06289892
91Cerebral hypomyelination (HP:0006808)2.05790910
92Round ear (HP:0100830)2.05306945
93Muscle stiffness (HP:0003552)2.04704348
94Hypoalphalipoproteinemia (HP:0003233)2.03899325
95Fetal akinesia sequence (HP:0001989)2.03597491
96Intrahepatic cholestasis (HP:0001406)2.03081684
97Hyperglycinuria (HP:0003108)2.01802578
98Hyperammonemia (HP:0001987)2.01311157
99Increased variability in muscle fiber diameter (HP:0003557)2.01005975
100Truncal ataxia (HP:0002078)2.00944359
101Abnormality of glycine metabolism (HP:0010895)1.99669132
102Abnormality of serine family amino acid metabolism (HP:0010894)1.99669132
103EMG: neuropathic changes (HP:0003445)1.99028037
104Calf muscle hypertrophy (HP:0008981)1.98475187
105Delayed CNS myelination (HP:0002188)1.98148420
106Annular pancreas (HP:0001734)1.97931233
107Bronchomalacia (HP:0002780)1.97409997
108Abnormal atrioventricular conduction (HP:0005150)1.97138732
109Muscle hypertrophy of the lower extremities (HP:0008968)1.97048383
110Increased connective tissue (HP:0009025)1.96057179
111Mildly elevated creatine phosphokinase (HP:0008180)1.93359777
112Increased circulating renin level (HP:0000848)1.93201578
113Spastic gait (HP:0002064)1.92829666
114Apathy (HP:0000741)1.92800077
115Stridor (HP:0010307)1.92040191
116Distal upper limb amyotrophy (HP:0007149)1.91370545
117Upper limb amyotrophy (HP:0009129)1.91370545
118Syncope (HP:0001279)1.91051867
119Hyperglycinemia (HP:0002154)1.89342994
120Frequent falls (HP:0002359)1.88412128
121Bradykinesia (HP:0002067)1.88182141
122Achilles tendon contracture (HP:0001771)1.87230016
123Lower limb asymmetry (HP:0100559)1.86603254
124Tetraplegia (HP:0002445)1.86385162
125Abnormal EKG (HP:0003115)1.85590066
126Hypercortisolism (HP:0001578)1.84927813
127Lower limb amyotrophy (HP:0007210)1.84872458
128Peripheral hypomyelination (HP:0007182)1.84000490
129Cerebral aneurysm (HP:0004944)1.83722368
130Hemiparesis (HP:0001269)1.83029888
131Myotonia (HP:0002486)1.82721251
132Slow progression (HP:0003677)1.81663215
133Impaired smooth pursuit (HP:0007772)1.81472695
134Neonatal onset (HP:0003623)1.81106371
135Cholecystitis (HP:0001082)1.80152678
136Abnormal gallbladder physiology (HP:0012438)1.80152678
137Lower limb muscle weakness (HP:0007340)1.79973321
138Central scotoma (HP:0000603)1.79812201
139Ventricular arrhythmia (HP:0004308)1.79204024
140Hyperkalemia (HP:0002153)1.76894545
141Amblyopia (HP:0000646)1.76395989
142Genetic anticipation (HP:0003743)1.73871356
143Megalencephaly (HP:0001355)1.73530229
144Cholelithiasis (HP:0001081)1.73368236
145Abnormality of the periventricular white matter (HP:0002518)1.72754898
146Termporal pattern (HP:0011008)1.72443241

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.55651997
2NTRK33.77615367
3MAP3K93.01076987
4DAPK22.78674280
5KSR22.37799140
6PRKD32.24955359
7MAP3K42.24944751
8PAK62.01466648
9MAP2K41.96767211
10CAMKK11.93573842
11TRIB31.79993685
12MINK11.79710391
13RIPK11.70267643
14PINK11.67438981
15STK381.67266838
16PHKG21.65011318
17PHKG11.65011318
18NTRK11.64303990
19NTRK21.56578886
20MAP3K21.56560944
21TYRO31.38810205
22PRPF4B1.38633377
23LMTK21.35835468
24MARK11.30326104
25MAP3K131.28158508
26RIPK41.27846120
27CDK51.27053359
28KSR11.25975784
29MAP2K71.25137555
30EEF2K1.19459562
31MAP3K71.16334632
32PRKCH1.14095505
33SGK4941.13966716
34SGK2231.13966716
35SGK31.13018718
36TAOK11.12025665
37RET1.03170899
38SIK21.02505061
39DAPK11.02365636
40SGK20.98941703
41CAMKK20.98458700
42CAMK1G0.97928025
43PDPK10.97436470
44PKN20.97200515
45SIK10.95919660
46TTN0.95904569
47BCKDK0.95682371
48FES0.94817689
49NEK10.94214928
50NEK60.92893763
51OXSR10.91522812
52PRKCG0.89552232
53TESK10.89214619
54STK110.87140818
55PDK10.87006287
56PTK2B0.86778859
57CAMK10.86219508
58FGFR20.85754898
59PAK30.85639679
60ARAF0.85119304
61CASK0.82664008
62CDK190.82220332
63WNK10.81287856
64PDK30.78457513
65PDK40.78457513
66DMPK0.77263730
67SGK10.76699372
68WNK40.75581399
69TNIK0.75402757
70PDGFRA0.74490146
71OBSCN0.74114958
72MAP3K10.73696683
73CDK11A0.73410087
74GRK50.73215019
75MAPK100.73091516
76INSRR0.72542711
77CAMK2A0.72273438
78MAP3K110.72118413
79DYRK1A0.70583293
80LIMK10.68330901
81PLK20.67581963
82MARK20.67409087
83CAMK1D0.66566223
84MAP2K10.65574605
85CAMK40.63707036
86DAPK30.61082412
87CAMK2G0.60532705
88FER0.60078589
89MAPK120.59218486
90MOS0.58752194
91ROCK20.58207132
92RAF10.57835476
93PRKCZ0.57485827
94BRAF0.56419714
95RPS6KA30.56384969
96CAMK2B0.54722639
97CDC42BPA0.54122769
98TNK20.53238617
99DDR20.52424703
100UHMK10.52079901
101MAPK70.51404637
102PKN10.51065553
103PRKD10.50641677
104ALK0.50553469
105FGFR40.50522749
106CDK150.50197413
107LATS20.48749862
108CAMK2D0.48387835
109RPS6KA20.47906672
110CDK180.46682696
111BMX0.45842684
112SMG10.45437473
113ERN10.45426441
114ICK0.45126612
115PRKG20.45092351
116PRKAA10.44933691
117MAP2K60.44845111
118MAPK40.44550503
119ROCK10.44374604
120CDK140.43134217
121DYRK1B0.42905582
122TAOK20.41935476
123PRKACG0.41665417
124MAPK130.41475292
125PDK20.41392416
126PRKD20.40812178
127FYN0.40406794
128PTK20.40394694

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.55739315
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.34493976
3Nicotine addiction_Homo sapiens_hsa050332.04781095
4Olfactory transduction_Homo sapiens_hsa047401.98794232
5Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.97665993
6Arginine biosynthesis_Homo sapiens_hsa002201.95709450
7GABAergic synapse_Homo sapiens_hsa047271.91209280
8Circadian entrainment_Homo sapiens_hsa047131.88918166
9Synaptic vesicle cycle_Homo sapiens_hsa047211.87402919
10Primary bile acid biosynthesis_Homo sapiens_hsa001201.82495977
11Glutamatergic synapse_Homo sapiens_hsa047241.74752641
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.66131837
13Long-term potentiation_Homo sapiens_hsa047201.65880147
14Morphine addiction_Homo sapiens_hsa050321.64457972
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.58788689
16Salivary secretion_Homo sapiens_hsa049701.57368231
17Amphetamine addiction_Homo sapiens_hsa050311.54471613
18Butanoate metabolism_Homo sapiens_hsa006501.50886871
19Bile secretion_Homo sapiens_hsa049761.50662139
20Gastric acid secretion_Homo sapiens_hsa049711.45847988
212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.44639834
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.42675663
23Insulin secretion_Homo sapiens_hsa049111.41861292
24Fatty acid degradation_Homo sapiens_hsa000711.35388847
25Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.33575676
26Renin secretion_Homo sapiens_hsa049241.32231281
27Histidine metabolism_Homo sapiens_hsa003401.31971435
28Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.30967209
29Dopaminergic synapse_Homo sapiens_hsa047281.30735814
30Vitamin B6 metabolism_Homo sapiens_hsa007501.28700106
31Cholinergic synapse_Homo sapiens_hsa047251.27648341
32Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.26373728
33Propanoate metabolism_Homo sapiens_hsa006401.26238481
34Oxytocin signaling pathway_Homo sapiens_hsa049211.23500110
35PPAR signaling pathway_Homo sapiens_hsa033201.19141085
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.16027353
37Fatty acid metabolism_Homo sapiens_hsa012121.15823444
38Cocaine addiction_Homo sapiens_hsa050301.14523961
39Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.14032160
40Calcium signaling pathway_Homo sapiens_hsa040201.13755607
41Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.10198185
42Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.07813569
43Arginine and proline metabolism_Homo sapiens_hsa003301.07012333
44Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.06431724
45Type II diabetes mellitus_Homo sapiens_hsa049301.05945049
46GnRH signaling pathway_Homo sapiens_hsa049121.02826294
47Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.01465873
48Tryptophan metabolism_Homo sapiens_hsa003800.95918490
49Fatty acid biosynthesis_Homo sapiens_hsa000610.95346329
50Long-term depression_Homo sapiens_hsa047300.95165167
51cAMP signaling pathway_Homo sapiens_hsa040240.94028974
52Taste transduction_Homo sapiens_hsa047420.93984372
53Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.85716192
54Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.84917892
55Dilated cardiomyopathy_Homo sapiens_hsa054140.84681481
56cGMP-PKG signaling pathway_Homo sapiens_hsa040220.82849106
57Gap junction_Homo sapiens_hsa045400.82123648
58Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.81572336
59Thyroid hormone signaling pathway_Homo sapiens_hsa049190.80756589
60Glucagon signaling pathway_Homo sapiens_hsa049220.79628787
61Cardiac muscle contraction_Homo sapiens_hsa042600.76933535
62Phosphatidylinositol signaling system_Homo sapiens_hsa040700.76498890
63beta-Alanine metabolism_Homo sapiens_hsa004100.75912191
64Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.75622683
65VEGF signaling pathway_Homo sapiens_hsa043700.75526260
66Inositol phosphate metabolism_Homo sapiens_hsa005620.74385989
67Vascular smooth muscle contraction_Homo sapiens_hsa042700.73595215
68Serotonergic synapse_Homo sapiens_hsa047260.72740387
69Pyruvate metabolism_Homo sapiens_hsa006200.72729933
70Estrogen signaling pathway_Homo sapiens_hsa049150.70689482
71Glycerolipid metabolism_Homo sapiens_hsa005610.70032034
72Neurotrophin signaling pathway_Homo sapiens_hsa047220.68962934
73Glioma_Homo sapiens_hsa052140.68041144
74Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.67283464
75Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.66336724
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.66223167
77Thyroid hormone synthesis_Homo sapiens_hsa049180.65608777
78Complement and coagulation cascades_Homo sapiens_hsa046100.64421512
79Carbon metabolism_Homo sapiens_hsa012000.63922651
80Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.62866143
81Dorso-ventral axis formation_Homo sapiens_hsa043200.62706247
82Phospholipase D signaling pathway_Homo sapiens_hsa040720.62688944
83Circadian rhythm_Homo sapiens_hsa047100.62349127
84Cyanoamino acid metabolism_Homo sapiens_hsa004600.62127722
85Carbohydrate digestion and absorption_Homo sapiens_hsa049730.61502462
86Pancreatic secretion_Homo sapiens_hsa049720.60261935
87Peroxisome_Homo sapiens_hsa041460.58084640
88Phenylalanine metabolism_Homo sapiens_hsa003600.56963891
89Biosynthesis of amino acids_Homo sapiens_hsa012300.56722118
90Vibrio cholerae infection_Homo sapiens_hsa051100.56440403
91Starch and sucrose metabolism_Homo sapiens_hsa005000.55957378
92Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.55786999
93Melanogenesis_Homo sapiens_hsa049160.55441444
94Insulin signaling pathway_Homo sapiens_hsa049100.54918900
95Rap1 signaling pathway_Homo sapiens_hsa040150.54670342
96Insulin resistance_Homo sapiens_hsa049310.53687461
97ABC transporters_Homo sapiens_hsa020100.51962620
98MAPK signaling pathway_Homo sapiens_hsa040100.51870466
99Tight junction_Homo sapiens_hsa045300.51606426
100Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.50295410
101Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.49619406
102Endocytosis_Homo sapiens_hsa041440.48630150
103Longevity regulating pathway - mammal_Homo sapiens_hsa042110.47942082
104Tyrosine metabolism_Homo sapiens_hsa003500.47857012
105Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.47395021
106ErbB signaling pathway_Homo sapiens_hsa040120.47257331
107Prion diseases_Homo sapiens_hsa050200.46708880
108Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.46448585
109Ras signaling pathway_Homo sapiens_hsa040140.45892944
110Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.45802539
111Mineral absorption_Homo sapiens_hsa049780.45777855
112Choline metabolism in cancer_Homo sapiens_hsa052310.44319058
113Protein digestion and absorption_Homo sapiens_hsa049740.43172268
114Sphingolipid signaling pathway_Homo sapiens_hsa040710.43165528
115AMPK signaling pathway_Homo sapiens_hsa041520.42387799
116Axon guidance_Homo sapiens_hsa043600.40740092
117Collecting duct acid secretion_Homo sapiens_hsa049660.40644917
118Glycerophospholipid metabolism_Homo sapiens_hsa005640.40388718
119mTOR signaling pathway_Homo sapiens_hsa041500.40152223
120Endometrial cancer_Homo sapiens_hsa052130.36291529
121Focal adhesion_Homo sapiens_hsa045100.34197988
122Ovarian steroidogenesis_Homo sapiens_hsa049130.33687254
123Oocyte meiosis_Homo sapiens_hsa041140.33649407
124Renal cell carcinoma_Homo sapiens_hsa052110.33095759

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