TEK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a receptor that belongs to the protein tyrosine kinase Tie2 family. The encoded protein possesses a unique extracellular region that contains two immunoglobulin-like domains, three epidermal growth factor (EGF)-like domains and three fibronectin type III repeats. The ligand angiopoietin-1 binds to this receptor and mediates a signaling pathway that functions in embryonic vascular development. Mutations in this gene are associated with inherited venous malformations of the skin and mucous membranes. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vascular endothelial growth factor signaling pathway (GO:0038084)9.28068812
2lymph vessel development (GO:0001945)8.46580871
3endothelium development (GO:0003158)7.75118258
4cellular response to vascular endothelial growth factor stimulus (GO:0035924)6.90156615
5positive regulation of vasculogenesis (GO:2001214)6.89336551
6surfactant homeostasis (GO:0043129)6.83894748
7fat-soluble vitamin biosynthetic process (GO:0042362)6.69048750
8lymphangiogenesis (GO:0001946)6.54212184
9blood vessel maturation (GO:0001955)6.38230846
10morphogenesis of an endothelium (GO:0003159)6.34880350
11endothelial tube morphogenesis (GO:0061154)6.34880350
12regulation of vasculogenesis (GO:2001212)5.88963063
13regulation of endothelial cell differentiation (GO:0045601)5.71608833
14retina vasculature morphogenesis in camera-type eye (GO:0061299)5.47156610
15vascular endothelial growth factor receptor signaling pathway (GO:0048010)5.39365361
16chemical homeostasis within a tissue (GO:0048875)5.35019096
17peptidyl-tyrosine autophosphorylation (GO:0038083)5.19443292
18patterning of blood vessels (GO:0001569)5.02515982
19endothelial cell differentiation (GO:0045446)4.78756609
20cAMP biosynthetic process (GO:0006171)4.47815022
21* sprouting angiogenesis (GO:0002040)4.42553347
22negative regulation of vascular permeability (GO:0043116)4.39635326
23positive regulation of endothelial cell differentiation (GO:0045603)4.32790999
24cell migration involved in sprouting angiogenesis (GO:0002042)4.25850034
25endothelial cell morphogenesis (GO:0001886)4.24343204
26venous blood vessel morphogenesis (GO:0048845)4.24242364
27blood vessel endothelial cell migration (GO:0043534)4.22137903
28basement membrane organization (GO:0071711)4.07572444
29establishment of endothelial barrier (GO:0061028)3.97263508
30protein kinase C signaling (GO:0070528)3.95166510
31vasculogenesis (GO:0001570)3.91046160
32neuron remodeling (GO:0016322)3.83904164
33regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)3.83257767
34glomerular filtration (GO:0003094)3.78516481
35positive regulation of dendritic spine morphogenesis (GO:0061003)3.77223929
36renal filtration (GO:0097205)3.75126375
37embryonic heart tube development (GO:0035050)3.72902708
38response to pheromone (GO:0019236)3.66803772
39lung vasculature development (GO:0060426)3.66016537
40wound healing, spreading of cells (GO:0044319)3.63963131
41positive regulation of urine volume (GO:0035810)3.62148061
42ovulation from ovarian follicle (GO:0001542)3.60715051
43transcytosis (GO:0045056)3.60287716
44positive regulation of pathway-restricted SMAD protein phosphorylation (GO:0010862)3.49796036
45negative regulation of focal adhesion assembly (GO:0051895)3.44517405
46negative regulation of cell junction assembly (GO:1901889)3.44517405
47negative regulation of adherens junction organization (GO:1903392)3.44517405
48negative regulation of DNA biosynthetic process (GO:2000279)3.42231413
49* heart trabecula formation (GO:0060347)3.40846760
50negative regulation of nitric-oxide synthase activity (GO:0051001)3.38432297
51cGMP-mediated signaling (GO:0019934)3.36237400
52negative regulation of blood vessel endothelial cell migration (GO:0043537)3.31552939
53regulation of cell migration involved in sprouting angiogenesis (GO:0090049)3.31092745
54artery development (GO:0060840)3.30674994
55smooth muscle tissue development (GO:0048745)3.30493381
56substrate-dependent cell migration (GO:0006929)3.30061946
57cell adhesion mediated by integrin (GO:0033627)3.28148286
58lung lobe morphogenesis (GO:0060463)3.24825989
59positive regulation of receptor recycling (GO:0001921)3.24247898
60negative regulation of cardiac muscle tissue growth (GO:0055022)3.23703185
61negative regulation of heart growth (GO:0061117)3.23703185
62endodermal cell differentiation (GO:0035987)3.21731904
63blood vessel remodeling (GO:0001974)3.16054636
64blood vessel morphogenesis (GO:0048514)3.15109880
65ventricular trabecula myocardium morphogenesis (GO:0003222)3.11329522
66negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)3.09097676
67negative regulation of endothelial cell migration (GO:0010596)3.07830308
68cell migration involved in heart development (GO:0060973)3.01981088
69positive regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030949)3.01921610
70coronary vasculature morphogenesis (GO:0060977)3.01244522
71* endothelial cell proliferation (GO:0001935)3.01013028
72vitamin transmembrane transport (GO:0035461)3.00693638
73gland morphogenesis (GO:0022612)2.98139725
74chondrocyte proliferation (GO:0035988)2.97758584
75paraxial mesoderm development (GO:0048339)2.95189927
76mRNA transcription from RNA polymerase II promoter (GO:0042789)2.94278722
77negative regulation of endothelial cell proliferation (GO:0001937)2.92448748
78Notch signaling involved in heart development (GO:0061314)2.91774577
79response to BMP (GO:0071772)2.90232879
80cellular response to BMP stimulus (GO:0071773)2.90232879
81dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.89603782
82angiogenesis involved in wound healing (GO:0060055)2.88535719
83cardiac muscle hypertrophy (GO:0003300)2.85476239
84cyclic purine nucleotide metabolic process (GO:0052652)2.84960101
85SMAD protein complex assembly (GO:0007183)2.84543900
86negative regulation of cardiac muscle tissue development (GO:0055026)2.83432915
87anatomical structure maturation (GO:0071695)2.81898845
88cardiac muscle cell proliferation (GO:0060038)2.81857001
89* negative regulation of endothelial cell apoptotic process (GO:2000352)2.81813705
90heart trabecula morphogenesis (GO:0061384)2.81812200
91positive regulation of endothelial cell apoptotic process (GO:2000353)2.81636431
92nephron epithelium development (GO:0072009)2.81005735
93negative regulation of epithelial cell migration (GO:0010633)2.80135331
94endothelial cell chemotaxis (GO:0035767)2.79671293
95regulation of phospholipid biosynthetic process (GO:0071071)2.79336157
96negative regulation of Rho protein signal transduction (GO:0035024)2.79005094
97* substrate adhesion-dependent cell spreading (GO:0034446)2.78746570
98endothelial cell migration (GO:0043542)2.78730133
99pathway-restricted SMAD protein phosphorylation (GO:0060389)2.78048625
100negative regulation of platelet activation (GO:0010544)2.77024456
101glomerular visceral epithelial cell development (GO:0072015)2.75720413
102neuron projection extension involved in neuron projection guidance (GO:1902284)2.75259173
103axon extension involved in axon guidance (GO:0048846)2.75259173
104adherens junction assembly (GO:0034333)2.75008500
105glomerular epithelial cell development (GO:0072310)2.74566462
106glomerular basement membrane development (GO:0032836)2.74170386
107trabecula morphogenesis (GO:0061383)2.73988069
108striated muscle hypertrophy (GO:0014897)2.71520613
109regulation of cardioblast differentiation (GO:0051890)2.70971173
110hyaluronan catabolic process (GO:0030214)2.70831320
111positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-2.69985611
112cyclic nucleotide biosynthetic process (GO:0009190)2.69794594
113endothelial cell development (GO:0001885)2.67761241
114* regulation of vascular permeability (GO:0043114)2.67097500
115* negative regulation of angiogenesis (GO:0016525)2.66790310
116* regulation of endothelial cell migration (GO:0010594)2.64740652
117positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.63910996
118regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.63451602
119wound healing, spreading of epidermal cells (GO:0035313)2.61939479
120* angiogenesis (GO:0001525)2.61492454
121hippo signaling (GO:0035329)2.60328992
122gap junction assembly (GO:0016264)2.59537279
123mRNA transcription (GO:0009299)2.59473311
124organ formation (GO:0048645)2.59441069
125bundle of His cell to Purkinje myocyte communication (GO:0086069)2.59034051
126artery morphogenesis (GO:0048844)2.57853424
127muscle filament sliding (GO:0030049)2.57372622
128actin-myosin filament sliding (GO:0033275)2.57372622
129Notch receptor processing (GO:0007220)2.57149681
130regulation of blood vessel endothelial cell migration (GO:0043535)2.56824252
131positive regulation of vascular permeability (GO:0043117)2.56015335
132negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.55591115
133protein localization to endosome (GO:0036010)2.55310902
134cAMP metabolic process (GO:0046058)2.50539452
135sodium-independent organic anion transport (GO:0043252)2.49889450
136cardiac myofibril assembly (GO:0055003)2.49462222
137* positive regulation of endothelial cell migration (GO:0010595)2.49382226
138exocrine pancreas development (GO:0031017)2.48865227
139low-density lipoprotein particle clearance (GO:0034383)2.47757409
140* positive regulation of endothelial cell proliferation (GO:0001938)2.47544644
141renal absorption (GO:0070293)2.47328873

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA2_21666600_ChIP-Seq_HMVEC_Human3.97047470
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.84097962
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.33195057
4TRIM28_21343339_ChIP-Seq_HEK293_Human3.24514182
5CLOCK_20551151_ChIP-Seq_293T_Human3.23558792
6GATA1_22025678_ChIP-Seq_K562_Human3.21737291
7ESR1_20079471_ChIP-ChIP_T-47D_Human3.18790172
8RARG_19884340_ChIP-ChIP_MEFs_Mouse2.99616749
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.98514095
10EP300_21415370_ChIP-Seq_HL-1_Mouse2.82299828
11TP63_17297297_ChIP-ChIP_HaCaT_Human2.58817424
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.58179589
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.33726252
14KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.32707531
15KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.32707531
16KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.32707531
17ELK3_25401928_ChIP-Seq_HUVEC_Human2.23239899
18NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.15143246
19TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.13696974
20LXR_22158963_ChIP-Seq_LIVER_Mouse2.08388869
21STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.07137803
22TBX20_22328084_ChIP-Seq_HEART_Mouse1.95777286
23TBX20_22080862_ChIP-Seq_HEART_Mouse1.95777286
24ESR2_21235772_ChIP-Seq_MCF-7_Human1.91374399
25* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.89171301
26* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.88873204
27GATA1_19941826_ChIP-Seq_K562_Human1.88311843
28RXR_22158963_ChIP-Seq_LIVER_Mouse1.87737269
29ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.86007502
30PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.85162762
31NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.82161415
32PPAR_26484153_Chip-Seq_NCI-H1993_Human1.79633341
33EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.79283059
34ESR1_21235772_ChIP-Seq_MCF-7_Human1.76047446
35SCL_19346495_ChIP-Seq_HPC-7_Human1.73700382
36WT1_19549856_ChIP-ChIP_CCG9911_Human1.71215130
37HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.68759939
38PPARA_22158963_ChIP-Seq_LIVER_Mouse1.63066544
39STAT6_21828071_ChIP-Seq_BEAS2B_Human1.59753636
40* CJUN_26792858_Chip-Seq_BT549_Human1.57999312
41THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.54420775
42HIF1A_21447827_ChIP-Seq_MCF-7_Human1.53719761
43KDM2B_26808549_Chip-Seq_SUP-B15_Human1.51216988
44SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.50280348
45CDX2_20551321_ChIP-Seq_CACO-2_Human1.50157422
46EED_16625203_ChIP-ChIP_MESCs_Mouse1.49957308
47SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.48494867
48SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.47597969
49ZNF217_24962896_ChIP-Seq_MCF-7_Human1.47011505
50NFIB_24661679_ChIP-Seq_LUNG_Mouse1.45741587
51SMAD_19615063_ChIP-ChIP_OVARY_Human1.45206626
52BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.41602151
53CDX2_19796622_ChIP-Seq_MESCs_Mouse1.41490761
54SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.40041555
55ZNF263_19887448_ChIP-Seq_K562_Human1.39983078
56TCF4_18268006_ChIP-ChIP_LS174T_Human1.38825082
57TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.35299878
58SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.34105244
59STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.33946195
60CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.33879610
61IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.31100739
62SOX2_20726797_ChIP-Seq_SW620_Human1.27209063
63OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26233120
64MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.26151785
65SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.26030668
66ZFP57_27257070_Chip-Seq_ESCs_Mouse1.25645919
67SOX9_24532713_ChIP-Seq_HFSC_Mouse1.25108594
68FOXO3_23340844_ChIP-Seq_DLD1_Human1.22938824
69NR3C1_23031785_ChIP-Seq_PC12_Mouse1.22690158
70PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.22464599
71MTF2_20144788_ChIP-Seq_MESCs_Mouse1.21604070
72TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21267153
73ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.20988111
74KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.20534457
75YAP1_20516196_ChIP-Seq_MESCs_Mouse1.19856209
76RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.16367883
77ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.16314140
78PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.12910218
79SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.12803908
80SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.12803908
81TCF3_18692474_ChIP-Seq_MEFs_Mouse1.12689102
82NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.10654607
83CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.09775565
84FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.09493611
85SMAD4_21799915_ChIP-Seq_A2780_Human1.08820347
86TBX3_20139965_ChIP-Seq_ESCs_Mouse1.08615601
87TBX3_20139965_ChIP-Seq_MESCs_Mouse1.08035945
88SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07536208
89TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.07198430
90GATA2_19941826_ChIP-Seq_K562_Human1.06919240
91STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.06705365
92PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.06682932
93FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.06431890
94ISL1_27105846_Chip-Seq_CPCs_Mouse1.06120596
95FOXA2_19822575_ChIP-Seq_HepG2_Human1.05796347
96TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05427279
97PIAS1_25552417_ChIP-Seq_VCAP_Human1.05287647
98P300_19829295_ChIP-Seq_ESCs_Human1.04627087
99PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.04065473
100STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.03716255
101SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.03217621
102POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.03130550
103SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.02793588
104FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.02713128
105AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.02612745
106RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01924164
107RNF2_18974828_ChIP-Seq_MESCs_Mouse1.01501569
108EZH2_18974828_ChIP-Seq_MESCs_Mouse1.01501569
109TCF3_18692474_ChIP-Seq_MESCs_Mouse1.01065164
110CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.00969654
111KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.99359831
112LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99251612
113TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99132650
114JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98440074
115SMAD3_21741376_ChIP-Seq_HESCs_Human0.97681214
116SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97532522
117GF1_26923725_Chip-Seq_HPCs_Mouse0.97476112
118KDM2B_26808549_Chip-Seq_K562_Human0.97463689
119AHR_22903824_ChIP-Seq_MCF-7_Human0.97304628
120RUNX_20019798_ChIP-Seq_JUKART_Human0.97015301
121NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.96526122
122* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.96443489
123AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.95726965
124SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.95492559
125WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.95233163
126GBX2_23144817_ChIP-Seq_PC3_Human0.93889107
127TP53_18474530_ChIP-ChIP_U2OS_Human0.93751560
128LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.93324056
129SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.93247356
130SMAD4_21741376_ChIP-Seq_HESCs_Human0.92898338
131* BRD4_25478319_ChIP-Seq_HGPS_Human0.92472987
132TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.91769509
133WT1_25993318_ChIP-Seq_PODOCYTE_Human0.91553188
134SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.91542696
135RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.90998596
136RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.89843762
137PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.89176299
138JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88679834
139DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.87412830
140NRF2_20460467_ChIP-Seq_MEFs_Mouse0.87311816
141NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.87311816
142GATA1_19941827_ChIP-Seq_MEL_Mouse0.86631613
143HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.86613010
144BCAT_22108803_ChIP-Seq_LS180_Human0.84392071
145NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.83257592

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010368_abnormal_lymphatic_system7.62328009
2MP0001879_abnormal_lymphatic_vessel6.03611063
3MP0005167_abnormal_blood-brain_barrier5.43118982
4MP0004272_abnormal_basement_membrane4.33031904
5MP0003724_increased_susceptibility_to3.68629659
6MP0003828_pulmonary_edema3.36418242
7MP0006054_spinal_hemorrhage2.91520503
8MP0004084_abnormal_cardiac_muscle2.90664555
9* MP0006138_congestive_heart_failure2.38236701
10MP0002138_abnormal_hepatobiliary_system2.36191237
11MP0000767_abnormal_smooth_muscle2.10296496
12MP0004484_altered_response_of2.01863448
13MP0010030_abnormal_orbit_morphology1.96716983
14MP0005165_increased_susceptibility_to1.90459204
15MP0001958_emphysema1.89808149
16MP0003941_abnormal_skin_development1.86109589
17MP0004036_abnormal_muscle_relaxation1.79393240
18MP0003279_aneurysm1.74997097
19MP0004215_abnormal_myocardial_fiber1.74691508
20MP0003705_abnormal_hypodermis_morpholog1.73973469
21MP0003567_abnormal_fetal_cardiomyocyte1.71278956
22* MP0001544_abnormal_cardiovascular_syste1.69528455
23* MP0005385_cardiovascular_system_phenoty1.69528455
24MP0004782_abnormal_surfactant_physiolog1.61844230
25MP0004147_increased_porphyrin_level1.61473099
26MP0003943_abnormal_hepatobiliary_system1.61058398
27MP0005595_abnormal_vascular_smooth1.58764294
28MP0000249_abnormal_blood_vessel1.54738464
29MP0005670_abnormal_white_adipose1.50430893
30MP0005623_abnormal_meninges_morphology1.50147504
31MP0005330_cardiomyopathy1.49713868
32MP0005360_urolithiasis1.48203925
33MP0000343_altered_response_to1.47587006
34MP0003303_peritoneal_inflammation1.46337800
35* MP0010630_abnormal_cardiac_muscle1.44382113
36* MP0002128_abnormal_blood_circulation1.42655358
37MP0003191_abnormal_cellular_cholesterol1.39277337
38MP0008775_abnormal_heart_ventricle1.34662310
39MP0002877_abnormal_melanocyte_morpholog1.34531054
40* MP0002925_abnormal_cardiovascular_devel1.33453862
41MP0000465_gastrointestinal_hemorrhage1.33399973
42MP0003566_abnormal_cell_adhesion1.33128962
43MP0004130_abnormal_muscle_cell1.32488147
44MP0002332_abnormal_exercise_endurance1.32420654
45MP0002127_abnormal_cardiovascular_syste1.32289826
46MP0000013_abnormal_adipose_tissue1.31971474
47MP0002972_abnormal_cardiac_muscle1.30539917
48MP0009278_abnormal_bone_marrow1.26544044
49* MP0001614_abnormal_blood_vessel1.21705651
50MP0004145_abnormal_muscle_electrophysio1.20657305
51MP0004883_abnormal_blood_vessel1.17881391
52MP0008438_abnormal_cutaneous_collagen1.14999632
53MP0003806_abnormal_nucleotide_metabolis1.14405957
54MP0003950_abnormal_plasma_membrane1.14011885
55MP0002933_joint_inflammation1.12914607
56MP0002295_abnormal_pulmonary_circulatio1.11041306
57MP0004085_abnormal_heartbeat1.07455392
58MP0002108_abnormal_muscle_morphology1.06355943
59MP0005620_abnormal_muscle_contractility1.04958011
60MP0000751_myopathy1.04804345
61MP0005164_abnormal_response_to1.03392250
62MP0005409_darkened_coat_color1.02713620
63MP0003868_abnormal_feces_composition1.01460931
64MP0001873_stomach_inflammation1.00983180
65MP0002133_abnormal_respiratory_system1.00821598
66MP0005388_respiratory_system_phenotype1.00821598
67MP0010352_gastrointestinal_tract_polyps0.98685164
68* MP0000266_abnormal_heart_morphology0.98185278
69MP0000230_abnormal_systemic_arterial0.96568403
70MP0003300_gastrointestinal_ulcer0.96094603
71MP0010329_abnormal_lipoprotein_level0.95065410
72MP0004233_abnormal_muscle_weight0.94745886
73MP0003385_abnormal_body_wall0.94441976
74MP0004087_abnormal_muscle_fiber0.94365225
75MP0005085_abnormal_gallbladder_physiolo0.92973561
76MP0005084_abnormal_gallbladder_morpholo0.89217926
77MP0003122_maternal_imprinting0.87931243
78MP0009384_cardiac_valve_regurgitation0.87510189
79* MP0003984_embryonic_growth_retardation0.86398434
80* MP0001784_abnormal_fluid_regulation0.85467929
81* MP0002088_abnormal_embryonic_growth/wei0.84757465
82MP0009697_abnormal_copulation0.83908912
83MP0000003_abnormal_adipose_tissue0.82938300
84MP0003878_abnormal_ear_physiology0.82370482
85MP0005377_hearing/vestibular/ear_phenot0.82370482
86MP0003091_abnormal_cell_migration0.81433716
87MP0003935_abnormal_craniofacial_develop0.80903116
88MP0008875_abnormal_xenobiotic_pharmacok0.79527555
89MP0008004_abnormal_stomach_pH0.79444119
90MP0003646_muscle_fatigue0.79201101
91MP0005369_muscle_phenotype0.79137189
92MP0005397_hematopoietic_system_phenotyp0.75983329
93MP0001545_abnormal_hematopoietic_system0.75983329
94MP0005275_abnormal_skin_tensile0.75916663
95MP0002837_dystrophic_cardiac_calcinosis0.75106725
96MP0009780_abnormal_chondrocyte_physiolo0.73903000
97MP0003119_abnormal_digestive_system0.73733931
98MP0004019_abnormal_vitamin_homeostasis0.72211579
99MP0001756_abnormal_urination0.71860394
100MP0009643_abnormal_urine_homeostasis0.71816840
101MP0002896_abnormal_bone_mineralization0.71585975
102MP0000049_abnormal_middle_ear0.71370994
103* MP0005380_embryogenesis_phenotype0.70750237
104* MP0001672_abnormal_embryogenesis/_devel0.70750237
105MP0000759_abnormal_skeletal_muscle0.70661314
106MP0003252_abnormal_bile_duct0.70395357
107MP0002106_abnormal_muscle_physiology0.69663017
108* MP0002086_abnormal_extraembryonic_tissu0.69230930
109MP0001299_abnormal_eye_distance/0.69069213
110MP0004808_abnormal_hematopoietic_stem0.67669222
111MP0000749_muscle_degeneration0.67069023
112MP0002139_abnormal_hepatobiliary_system0.66874682
113MP0005023_abnormal_wound_healing0.66801779
114MP0001849_ear_inflammation0.66357834
115MP0001175_abnormal_lung_morphology0.65496408
116MP0005365_abnormal_bile_salt0.65398761
117MP0005503_abnormal_tendon_morphology0.64784797
118MP0000537_abnormal_urethra_morphology0.64164205
119MP0000428_abnormal_craniofacial_morphol0.64116139
120MP0000750_abnormal_muscle_regeneration0.62962304
121MP0000747_muscle_weakness0.62724009
122MP0002166_altered_tumor_susceptibility0.59755876
123MP0005083_abnormal_biliary_tract0.58885453
124MP0000733_abnormal_muscle_development0.57807880
125MP0005666_abnormal_adipose_tissue0.57738366
126* MP0001915_intracranial_hemorrhage0.57491712
127MP0002254_reproductive_system_inflammat0.57261562
128MP0000516_abnormal_urinary_system0.55039758
129MP0005367_renal/urinary_system_phenotyp0.55039758
130MP0004510_myositis0.54833260
131MP0005508_abnormal_skeleton_morphology0.53172245
132MP0002084_abnormal_developmental_patter0.52739708
133MP0001661_extended_life_span0.52381543

Predicted human phenotypes

RankGene SetZ-score
1Polycythemia (HP:0001901)6.63155736
2Spontaneous hematomas (HP:0007420)5.83559978
3Hematochezia (HP:0002573)5.32498290
4Esophageal varix (HP:0002040)5.30740304
5Arterial tortuosity (HP:0005116)5.07685586
6Premature rupture of membranes (HP:0001788)4.43216623
7Broad metatarsal (HP:0001783)4.18522553
8Abnormality of the nasal mucosa (HP:0000433)4.15915183
9Nonimmune hydrops fetalis (HP:0001790)4.09415897
10Wrist flexion contracture (HP:0001239)3.90660471
11Lymphangioma (HP:0100764)3.75178981
12Portal hypertension (HP:0001409)3.63100895
13Cerebral hemorrhage (HP:0001342)3.61438726
14Annular pancreas (HP:0001734)3.60788110
15Deep venous thrombosis (HP:0002625)3.59835012
16Adactyly (HP:0009776)3.53205349
17Conjunctival telangiectasia (HP:0000524)3.42973526
18Mesangial abnormality (HP:0001966)3.41013509
19Hyperactive renin-angiotensin system (HP:0000841)3.37546020
20Abnormality of the hepatic vasculature (HP:0006707)3.30339595
21Hyperinsulinemic hypoglycemia (HP:0000825)3.29594126
22Abnormality of skeletal muscle fiber size (HP:0012084)3.23306911
23Type 1 muscle fiber predominance (HP:0003803)3.23063856
24Visceral angiomatosis (HP:0100761)3.22244690
25Cerebral aneurysm (HP:0004944)3.15075311
26Muscle fiber splitting (HP:0003555)3.14239709
27Hypoglycemic coma (HP:0001325)3.13903594
28Mitral valve prolapse (HP:0001634)3.10646127
29Shallow orbits (HP:0000586)3.09905804
30Hemangiomatosis (HP:0007461)3.07279770
31Absent hand (HP:0004050)3.05982256
32Atrial fibrillation (HP:0005110)3.04696758
33Joint hemorrhage (HP:0005261)3.02391398
34Ventricular tachycardia (HP:0004756)3.01353362
35Round ear (HP:0100830)2.98045855
36Abnormality of the vasculature of the conjunctiva (HP:0008054)2.93784632
37Supraventricular arrhythmia (HP:0005115)2.90421152
38Sudden death (HP:0001699)2.84504979
39Primary atrial arrhythmia (HP:0001692)2.80982804
40Nemaline bodies (HP:0003798)2.80919143
41Increased connective tissue (HP:0009025)2.77912092
42Porencephaly (HP:0002132)2.77690081
43Skull defect (HP:0001362)2.76944963
44Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.75798445
45Exercise-induced muscle cramps (HP:0003710)2.71744504
46Muscle fiber inclusion bodies (HP:0100299)2.71353108
47Hypoglycemic seizures (HP:0002173)2.66026970
48Supraventricular tachycardia (HP:0004755)2.65036615
49Aortic aneurysm (HP:0004942)2.64835105
50Myocardial infarction (HP:0001658)2.59152910
51Overgrowth (HP:0001548)2.57212742
52Hip contracture (HP:0003273)2.51346324
53Spinal rigidity (HP:0003306)2.45841970
54Growth hormone excess (HP:0000845)2.44113506
55Hemorrhage of the eye (HP:0011885)2.43890768
56Centrally nucleated skeletal muscle fibers (HP:0003687)2.43709638
57Hypokalemic alkalosis (HP:0001949)2.41229300
58Venous insufficiency (HP:0005293)2.41013497
59Striae distensae (HP:0001065)2.40277614
60Pancreatic islet-cell hyperplasia (HP:0004510)2.39772021
61Microcytic anemia (HP:0001935)2.36039931
62Lipoatrophy (HP:0100578)2.35397545
63Cavernous hemangioma (HP:0001048)2.35392888
64Ankle contracture (HP:0006466)2.35270423
65Abnormality of the intrinsic pathway (HP:0010989)2.35075282
66Pulmonary hypertension (HP:0002092)2.33485390
67Dilatation of the ascending aorta (HP:0005111)2.32972462
68Soft skin (HP:0000977)2.32877653
69Hyporeflexia of lower limbs (HP:0002600)2.32331768
70Pulmonary embolism (HP:0002204)2.31531100
71Petechiae (HP:0000967)2.29983001
72Right ventricular cardiomyopathy (HP:0011663)2.29707865
73Tetany (HP:0001281)2.28537405
74Vascular tortuosity (HP:0004948)2.28365461
75Ectopia lentis (HP:0001083)2.27512306
76Aneurysm (HP:0002617)2.27292811
77Stroke (HP:0001297)2.26769760
78Abnormality of fatty-acid metabolism (HP:0004359)2.26567451
79Protrusio acetabuli (HP:0003179)2.26481077
80Cervical subluxation (HP:0003308)2.26348874
81Distal arthrogryposis (HP:0005684)2.24489442
82Capillary hemangiomas (HP:0005306)2.22536523
83Aortic valve stenosis (HP:0001650)2.22465269
84Limited hip movement (HP:0008800)2.20691173
85Distal lower limb muscle weakness (HP:0009053)2.20235149
86Stenosis of the external auditory canal (HP:0000402)2.19706003
87Chondrocalcinosis (HP:0000934)2.17006057
88Disproportionate tall stature (HP:0001519)2.16511409
89Mucosal telangiectasiae (HP:0100579)2.15957469
90Venous abnormality (HP:0002624)2.15777976
91Blue sclerae (HP:0000592)2.15516850
92Facial diplegia (HP:0001349)2.13118343
93Interstitial pulmonary disease (HP:0006530)2.11317826
94Symptomatic seizures (HP:0011145)2.10479014
95Difficulty climbing stairs (HP:0003551)2.09922481
96Pulmonary artery stenosis (HP:0004415)2.09286738
97Neonatal death (HP:0003811)2.06105910
98Tetraparesis (HP:0002273)2.02503146
99Increased CSF protein (HP:0002922)2.02178265
100Abnormality of Sharpey fibers (HP:0100685)2.01434004
101Camptodactyly of toe (HP:0001836)2.01144811
102Wormian bones (HP:0002645)2.00994556
103Mildly elevated creatine phosphokinase (HP:0008180)2.00589989
104EMG: myopathic abnormalities (HP:0003458)1.99995802
105Impaired platelet aggregation (HP:0003540)1.98332239
106Abnormal platelet function (HP:0011869)1.98332239
107Hydroureter (HP:0000072)1.98265141
108Short 4th metacarpal (HP:0010044)1.98060601
109Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.98060601
110Thrombophlebitis (HP:0004418)1.97379230
111Short hallux (HP:0010109)1.97360090
112Hyperaldosteronism (HP:0000859)1.96141068
113Subacute progressive viral hepatitis (HP:0006572)1.95224526
114Abnormality of the calf musculature (HP:0001430)1.93752519
115Abnormal atrioventricular conduction (HP:0005150)1.93737233
116Dilated cardiomyopathy (HP:0001644)1.93255919
117Difficulty running (HP:0009046)1.93168609
118Syncope (HP:0001279)1.93085611
119Focal segmental glomerulosclerosis (HP:0000097)1.93007569
120Bladder diverticulum (HP:0000015)1.91964344
121Heart block (HP:0012722)1.91499969
122Joint contractures involving the joints of the feet (HP:0100492)1.87800828
123Flexion contracture of toe (HP:0005830)1.87800828
124Atrioventricular block (HP:0001678)1.87603391
125Neck muscle weakness (HP:0000467)1.86190180
126Aplasia/Hypoplasia of the hallux (HP:0008362)1.84926746
127Joint laxity (HP:0001388)1.84920380
128Increased circulating renin level (HP:0000848)1.84374321
129Facial shape deformation (HP:0011334)1.83244257
130Potter facies (HP:0002009)1.83244257
131Asymmetric septal hypertrophy (HP:0001670)1.82845257
132Abnormal pancreas size (HP:0012094)1.82658971
133Intrahepatic cholestasis (HP:0001406)1.82223617
134Aortic dissection (HP:0002647)1.81992746
135Autoimmune thrombocytopenia (HP:0001973)1.81975737
136Prolonged bleeding time (HP:0003010)1.81794555
137Pigmentary retinal degeneration (HP:0001146)1.81440178
138Bicuspid aortic valve (HP:0001647)1.80654119
139Renal salt wasting (HP:0000127)1.79563289
140Increased variability in muscle fiber diameter (HP:0003557)1.78524305
141Absent toe (HP:0010760)1.77292604
142Delayed CNS myelination (HP:0002188)1.76889116
143Abnormality of renin-angiotensin system (HP:0000847)1.76742226
144Congenital, generalized hypertrichosis (HP:0004540)1.76574783
145High pitched voice (HP:0001620)1.76568086
146Myotonia (HP:0002486)1.76410213
147Bundle branch block (HP:0011710)1.76117045
148Hypomagnesemia (HP:0002917)1.75776772
149Abnormality of the ischium (HP:0003174)1.75492807
150Vertebral clefting (HP:0008428)1.74926575
151Limb-girdle muscle atrophy (HP:0003797)1.74885506

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR7.05940629
2TGFBR23.87034799
3GRK13.49161367
4TGFBR13.08376343
5CAMK1D2.30086015
6* TIE111.1561002
7BMX1.91992433
8CAMK1G1.77226304
9EPHB21.46898193
10INSRR1.37356052
11MYLK1.36526981
12LATS21.36135752
13RIPK11.35565841
14PTK2B1.34817329
15BMPR1B1.34061692
16NTRK11.29265172
17FER1.23007637
18PTK61.13362512
19TSSK61.05970129
20MAP2K31.04978984
21PKN21.03879657
22PAK41.02978768
23TTN1.02424331
24PDK20.96718168
25FGFR40.93933108
26PDGFRA0.91961544
27AKT30.90445147
28ERN10.90297747
29TRIB30.90284998
30EPHB10.82134056
31MAPK120.82071362
32PRKAA20.71799708
33PRKG20.70829326
34PRKD10.70721582
35DMPK0.68552599
36MAP3K30.67075357
37LRRK20.66114185
38CAMK40.65635352
39NEK90.63424599
40PIK3CA0.62293661
41TRPM70.61963439
42MAP2K20.60651335
43KIT0.60334375
44MAP3K130.58648002
45OBSCN0.57395380
46STK38L0.56975741
47ROCK20.56484515
48CDK90.54466614
49SGK20.50860936
50PRKCE0.50711532
51DDR20.50421415
52EEF2K0.50145786
53ROCK10.49278305
54IGF1R0.47668469
55BCKDK0.47158497
56MOS0.45987580
57PRKCH0.45122956
58STK100.44062722
59PDPK10.44023290
60MAPK150.43631566
61MAPKAPK30.43564371
62SGK30.43377979
63MAPK70.42151305
64ARAF0.41993743
65CAMK10.41876511
66CSK0.41645846
67NLK0.40597319
68PIK3CG0.39704564
69PINK10.39244074
70STK240.38984909
71MAP2K10.37997558
72RET0.37949191
73ICK0.36457062
74PTK20.36233995
75ACVR1B0.36216909
76LMTK20.36170732
77SRC0.35841092
78GRK50.35795948
79AKT20.35216644
80TNIK0.35079330
81LATS10.33832473
82MAP3K70.33778626
83FGFR30.33777354
84PLK40.33237967
85SIK10.30915966
86GSK3A0.30623725
87SGK2230.29426017
88SGK4940.29426017
89JAK10.29282271
90PDGFRB0.29157547
91FGFR20.28449998
92PRKAA10.28000797
93WNK40.27919137
94CDC42BPA0.27822814
95INSR0.27395365
96MTOR0.26254307
97PRKD20.26128732
98MAP3K110.26090544
99LIMK10.25880483
100MET0.25617960
101PLK30.25448958
102ERBB40.24512235
103PAK20.23645601
104DAPK30.22696040
105ILK0.22524865
106JAK30.22003906
107RPS6KA20.21806727
108MAP3K10.21378662
109PRKD30.21224361
110TBK10.20968530
111CDK60.20901533
112MATK0.20723653
113PDK40.19359664
114PDK30.19359664
115PHKG20.19171688
116PHKG10.19171688
117CDK80.18843009
118FLT30.18093653
119PLK20.17413287
120CSNK1G10.17210734
121* EGFR0.17013356
122PRKG10.16653467
123FGFR10.16592213
124MARK20.16465448
125MAPK40.14686608
126JAK20.14213553
127STK30.13717714
128FES0.13580748
129MAPK100.12404956
130TTK0.11909611
131TESK10.11862271
132EPHA40.11316064
133TYRO30.10510323
134MAPKAPK50.10332950
135OXSR10.07808027
136CAMK2A0.07416381
137MAPK90.06109288

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045122.61859943
2Bile secretion_Homo sapiens_hsa049762.58825167
3Glycosaminoglycan degradation_Homo sapiens_hsa005312.38479855
4PPAR signaling pathway_Homo sapiens_hsa033202.34162394
5Adherens junction_Homo sapiens_hsa045202.30495087
6Focal adhesion_Homo sapiens_hsa045102.23703893
7Dilated cardiomyopathy_Homo sapiens_hsa054142.21809980
8Leukocyte transendothelial migration_Homo sapiens_hsa046702.05217712
9Complement and coagulation cascades_Homo sapiens_hsa046102.00659659
10Nitrogen metabolism_Homo sapiens_hsa009101.89753125
11Fatty acid degradation_Homo sapiens_hsa000711.86745014
12Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.82923064
13Ovarian steroidogenesis_Homo sapiens_hsa049131.74904223
142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.68941906
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.68935553
16Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.66998280
17Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.65639549
18Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.65285716
19Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.63333836
20Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.61652828
21Propanoate metabolism_Homo sapiens_hsa006401.60257512
22Arginine biosynthesis_Homo sapiens_hsa002201.58531240
23Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.55719968
24* Rap1 signaling pathway_Homo sapiens_hsa040151.49770406
25Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.47735843
26Primary bile acid biosynthesis_Homo sapiens_hsa001201.46201522
27Platelet activation_Homo sapiens_hsa046111.46094585
28AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.43068861
29Dorso-ventral axis formation_Homo sapiens_hsa043201.42736750
30Hippo signaling pathway_Homo sapiens_hsa043901.42671272
31Tryptophan metabolism_Homo sapiens_hsa003801.41863907
32Notch signaling pathway_Homo sapiens_hsa043301.37526506
33Small cell lung cancer_Homo sapiens_hsa052221.36760771
34Vitamin digestion and absorption_Homo sapiens_hsa049771.34128647
35Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.32564415
36* HIF-1 signaling pathway_Homo sapiens_hsa040661.31766333
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.21940649
38Vascular smooth muscle contraction_Homo sapiens_hsa042701.15312675
39Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.14989498
40* PI3K-Akt signaling pathway_Homo sapiens_hsa041511.14570564
41Aldosterone synthesis and secretion_Homo sapiens_hsa049251.14095243
42Tight junction_Homo sapiens_hsa045301.13271888
43Renin-angiotensin system_Homo sapiens_hsa046141.11976379
44Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.10195729
45Prion diseases_Homo sapiens_hsa050201.09040112
46Proteoglycans in cancer_Homo sapiens_hsa052051.08175557
47ABC transporters_Homo sapiens_hsa020101.08025472
48Amoebiasis_Homo sapiens_hsa051461.06391241
49Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.05741540
50Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.04743615
51Insulin resistance_Homo sapiens_hsa049311.04122594
52Fatty acid metabolism_Homo sapiens_hsa012121.03448004
53Basal cell carcinoma_Homo sapiens_hsa052171.02127902
54Caffeine metabolism_Homo sapiens_hsa002321.00631054
55Arginine and proline metabolism_Homo sapiens_hsa003300.99780418
56Gastric acid secretion_Homo sapiens_hsa049710.96769964
57Malaria_Homo sapiens_hsa051440.96004413
58Renin secretion_Homo sapiens_hsa049240.94654624
59cGMP-PKG signaling pathway_Homo sapiens_hsa040220.89327976
60Toxoplasmosis_Homo sapiens_hsa051450.87409183
61TGF-beta signaling pathway_Homo sapiens_hsa043500.87346858
62Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.86993538
63Viral myocarditis_Homo sapiens_hsa054160.86220035
64Protein digestion and absorption_Homo sapiens_hsa049740.85368211
65Longevity regulating pathway - mammal_Homo sapiens_hsa042110.85342951
66Estrogen signaling pathway_Homo sapiens_hsa049150.84276680
67Selenocompound metabolism_Homo sapiens_hsa004500.82869541
68Adipocytokine signaling pathway_Homo sapiens_hsa049200.80708974
69beta-Alanine metabolism_Homo sapiens_hsa004100.78590970
70Renal cell carcinoma_Homo sapiens_hsa052110.77043582
71Melanogenesis_Homo sapiens_hsa049160.76005199
72Pathways in cancer_Homo sapiens_hsa052000.74815536
73Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.72528988
74Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.72040786
75Thyroid cancer_Homo sapiens_hsa052160.72001165
76Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.69159833
77Gap junction_Homo sapiens_hsa045400.67545294
78Bladder cancer_Homo sapiens_hsa052190.67477026
79Thyroid hormone synthesis_Homo sapiens_hsa049180.67047300
80Butanoate metabolism_Homo sapiens_hsa006500.65894852
81* Ras signaling pathway_Homo sapiens_hsa040140.65097280
82Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.63887890
83Peroxisome_Homo sapiens_hsa041460.63112485
84Pancreatic cancer_Homo sapiens_hsa052120.62525663
85Phenylalanine metabolism_Homo sapiens_hsa003600.61077974
86VEGF signaling pathway_Homo sapiens_hsa043700.60922579
87African trypanosomiasis_Homo sapiens_hsa051430.60259338
88AMPK signaling pathway_Homo sapiens_hsa041520.59883461
89Pancreatic secretion_Homo sapiens_hsa049720.58510636
90Colorectal cancer_Homo sapiens_hsa052100.58458883
91Glucagon signaling pathway_Homo sapiens_hsa049220.57981319
92Calcium signaling pathway_Homo sapiens_hsa040200.56743027
93Endocytosis_Homo sapiens_hsa041440.55989415
94Wnt signaling pathway_Homo sapiens_hsa043100.55523666
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.54805190
96Serotonergic synapse_Homo sapiens_hsa047260.54272388
97Chronic myeloid leukemia_Homo sapiens_hsa052200.52548062
98Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.50245902
99Phospholipase D signaling pathway_Homo sapiens_hsa040720.49313315
100Hedgehog signaling pathway_Homo sapiens_hsa043400.49154013
101cAMP signaling pathway_Homo sapiens_hsa040240.48258519
102Regulation of actin cytoskeleton_Homo sapiens_hsa048100.47341283
103Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.46747099
104Pertussis_Homo sapiens_hsa051330.46746699
105Hepatitis C_Homo sapiens_hsa051600.46719099
106Staphylococcus aureus infection_Homo sapiens_hsa051500.45531868
107Carbon metabolism_Homo sapiens_hsa012000.44295854
108Salivary secretion_Homo sapiens_hsa049700.43833612
109Oxytocin signaling pathway_Homo sapiens_hsa049210.43302428
110Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.42689401
111Transcriptional misregulation in cancer_Homo sapiens_hsa052020.41012918
112Axon guidance_Homo sapiens_hsa043600.40954005
113Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.40802092
114MAPK signaling pathway_Homo sapiens_hsa040100.40677425
115Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.40671355
116Sulfur metabolism_Homo sapiens_hsa009200.39615748
117MicroRNAs in cancer_Homo sapiens_hsa052060.37149843
118Hematopoietic cell lineage_Homo sapiens_hsa046400.37130757
119HTLV-I infection_Homo sapiens_hsa051660.36175818
120Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.34951015
121Thyroid hormone signaling pathway_Homo sapiens_hsa049190.34809990
122Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.34341289
123Lysine degradation_Homo sapiens_hsa003100.34296708
124Histidine metabolism_Homo sapiens_hsa003400.33587807
125Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.32659279
126Melanoma_Homo sapiens_hsa052180.32029894
127Glutamatergic synapse_Homo sapiens_hsa047240.29768368
128GnRH signaling pathway_Homo sapiens_hsa049120.29280991
129Insulin signaling pathway_Homo sapiens_hsa049100.28139517
130Long-term depression_Homo sapiens_hsa047300.26950214
131Sphingolipid signaling pathway_Homo sapiens_hsa040710.26625933
132Shigellosis_Homo sapiens_hsa051310.25991384

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