TEKT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene product belongs to the tektin family of proteins. Tektins comprise a family of filament-forming proteins that are coassembled with tubulins to form ciliary and flagellar microtubules. This gene is predominantly expressed in the testis and in mouse, tektin 1 mRNA was localized to the spermatocytes and round spermatids in the seminiferous tubules, indicating that it may play a role in spermatogenesis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1binding of sperm to zona pellucida (GO:0007339)9.71112324
2acrosome reaction (GO:0007340)9.67306401
3plasma membrane fusion (GO:0045026)9.42845296
4cell-cell recognition (GO:0009988)9.34069597
5spermatid development (GO:0007286)8.43794185
6reproduction (GO:0000003)8.33920855
7piRNA metabolic process (GO:0034587)8.27345339
8regulation of cilium movement (GO:0003352)8.17130020
9male meiosis (GO:0007140)7.88451409
10primary alcohol catabolic process (GO:0034310)7.35344345
11synaptonemal complex organization (GO:0070193)7.20506273
12single fertilization (GO:0007338)7.09702267
13ventricular system development (GO:0021591)6.96335888
14synaptonemal complex assembly (GO:0007130)6.82622135
15vitamin transmembrane transport (GO:0035461)6.49449925
16ethanol metabolic process (GO:0006067)6.14026389
17sperm capacitation (GO:0048240)6.10519664
18fertilization (GO:0009566)6.02524038
19diterpenoid biosynthetic process (GO:0016102)5.85517763
20negative regulation of inclusion body assembly (GO:0090084)5.75230234
21spermatogenesis (GO:0007283)5.70994859
22male gamete generation (GO:0048232)5.68921462
23axoneme assembly (GO:0035082)5.62826047
24DNA methylation involved in gamete generation (GO:0043046)5.43897922
25GTP biosynthetic process (GO:0006183)5.36736781
26male meiosis I (GO:0007141)5.31722360
27nucleoside diphosphate phosphorylation (GO:0006165)5.25643008
28gamete generation (GO:0007276)5.23272479
29tolerance induction (GO:0002507)5.14381633
30lung epithelium development (GO:0060428)5.12252121
31response to xenobiotic stimulus (GO:0009410)5.10379880
32pyrimidine-containing compound transmembrane transport (GO:0072531)5.08337076
33intraciliary transport (GO:0042073)5.06254129
34one-carbon compound transport (GO:0019755)4.96651358
35regulation of microtubule-based movement (GO:0060632)4.96422892
36microtubule severing (GO:0051013)4.90945446
37regulation of inclusion body assembly (GO:0090083)4.90698571
38microtubule depolymerization (GO:0007019)4.83862032
39cellular process involved in reproduction in multicellular organism (GO:0022412)4.83613102
40germ cell development (GO:0007281)4.82535445
41UTP biosynthetic process (GO:0006228)4.81964050
42chromosome organization involved in meiosis (GO:0070192)4.81220639
43negative regulation of T cell differentiation in thymus (GO:0033085)4.71597193
44cell recognition (GO:0008037)4.70428570
45ethanol oxidation (GO:0006069)4.68344326
46organic cation transport (GO:0015695)4.68195064
47calcium ion-dependent exocytosis (GO:0017156)4.59003699
48establishment of apical/basal cell polarity (GO:0035089)4.57959155
49negative regulation of immunoglobulin mediated immune response (GO:0002890)4.57519109
50negative regulation of B cell mediated immunity (GO:0002713)4.57519109
51glomerular epithelial cell development (GO:0072310)4.53929347
52meiotic nuclear division (GO:0007126)4.52229365
53protein localization to cilium (GO:0061512)4.49030858
54regulation of interleukin-5 production (GO:0032674)4.37821286
55UTP metabolic process (GO:0046051)4.37442088
56spermatid nucleus differentiation (GO:0007289)4.35207192
57left/right pattern formation (GO:0060972)4.31759950
58negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)4.30456398
59centriole assembly (GO:0098534)4.28161201
60negative regulation of humoral immune response (GO:0002921)4.27652143
61cilium organization (GO:0044782)4.27515321
62meiosis I (GO:0007127)4.25851611
63seminiferous tubule development (GO:0072520)4.13419729
64protein polyglutamylation (GO:0018095)4.11807702
65positive regulation of tolerance induction (GO:0002645)4.11492350
66multicellular organismal reproductive process (GO:0048609)4.11321566
67cilium assembly (GO:0042384)4.08958556
68regulation of germinal center formation (GO:0002634)4.07457056
69retinoic acid metabolic process (GO:0042573)4.06643457
70terpenoid biosynthetic process (GO:0016114)4.04055470
71establishment or maintenance of monopolar cell polarity (GO:0061339)4.03372544
72establishment of monopolar cell polarity (GO:0061162)4.03372544
73regulation of interleukin-13 production (GO:0032656)3.94991646
74meiotic cell cycle (GO:0051321)3.94639519
75cilium morphogenesis (GO:0060271)3.87137477
76microtubule-based movement (GO:0007018)3.84886251
77centriole replication (GO:0007099)3.82488345
78chaperone-mediated protein complex assembly (GO:0051131)3.80034626
79guanosine-containing compound biosynthetic process (GO:1901070)3.78049924
80cellular component assembly involved in morphogenesis (GO:0010927)3.75492089
81left/right axis specification (GO:0070986)3.71074117
82cytoplasmic microtubule organization (GO:0031122)3.67792751
83establishment of planar polarity (GO:0001736)3.58298395
84establishment of tissue polarity (GO:0007164)3.58298395
85CTP metabolic process (GO:0046036)3.55618029
86CTP biosynthetic process (GO:0006241)3.55618029
87lateral ventricle development (GO:0021670)3.53616639
88genitalia morphogenesis (GO:0035112)3.53429712
89glycerol ether metabolic process (GO:0006662)3.52171123
90microtubule polymerization or depolymerization (GO:0031109)3.41525562
91exogenous drug catabolic process (GO:0042738)3.34636370
92pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.27525943
93ether metabolic process (GO:0018904)3.26019437
94primary alcohol metabolic process (GO:0034308)3.25013496
95positive regulation of smoothened signaling pathway (GO:0045880)3.22948762
96multicellular organismal development (GO:0007275)3.22019234
97monoubiquitinated protein deubiquitination (GO:0035520)3.19281434
98pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.17953052
99retinol metabolic process (GO:0042572)3.17683855
100negative regulation of organelle assembly (GO:1902116)3.11155325
101glutathione derivative biosynthetic process (GO:1901687)3.10302273
102glutathione derivative metabolic process (GO:1901685)3.10302273
103determination of left/right symmetry (GO:0007368)3.10294622
104protein refolding (GO:0042026)3.09380663
105regulation of centriole replication (GO:0046599)3.08418230
106synapsis (GO:0007129)3.05893929
107O-glycan processing (GO:0016266)3.05716444
108regulation of tolerance induction (GO:0002643)3.05076677
109chromosome condensation (GO:0030261)3.03975729
110pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)3.03786854
111hydrogen peroxide biosynthetic process (GO:0050665)3.02601997
112smoothened signaling pathway (GO:0007224)3.01639100
113lateral sprouting from an epithelium (GO:0060601)3.01581489
114determination of bilateral symmetry (GO:0009855)2.97853537
115specification of symmetry (GO:0009799)2.91896176
116DNA packaging (GO:0006323)2.91886762
117lactate metabolic process (GO:0006089)2.90565805
118carnitine metabolic process (GO:0009437)2.90225089
119protein K11-linked deubiquitination (GO:0035871)2.87432835
120microtubule bundle formation (GO:0001578)2.86794558
121gene silencing by RNA (GO:0031047)2.85070612
122regulation of microtubule depolymerization (GO:0031114)2.84086275
123meiotic cell cycle process (GO:1903046)2.83653648
124aldehyde catabolic process (GO:0046185)2.82886670
125nucleotide phosphorylation (GO:0046939)2.82501682
126apical protein localization (GO:0045176)2.81557529
127pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.79678807
128microtubule-based process (GO:0007017)2.77500133
129regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.73863903
130multicellular organismal water homeostasis (GO:0050891)2.73608770
131retinal rod cell development (GO:0046548)2.73081624
132phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.72169605
133reactive oxygen species biosynthetic process (GO:1903409)2.68425170
134nucleoside diphosphate metabolic process (GO:0009132)2.65141004
135organelle assembly (GO:0070925)2.63303427
136glycolytic process (GO:0006096)2.61459802
137sequestering of actin monomers (GO:0042989)2.61369160
138alditol metabolic process (GO:0019400)2.61003772
139cell projection assembly (GO:0030031)2.60136541
140drug catabolic process (GO:0042737)2.57515172
141single strand break repair (GO:0000012)2.56686619
142amino-acid betaine transport (GO:0015838)2.56616287
143carnitine transport (GO:0015879)2.56616287
144phosphatidylcholine biosynthetic process (GO:0006656)2.56512350
145progesterone metabolic process (GO:0042448)2.53954937
146regulation of autophagic vacuole assembly (GO:2000785)2.51280566
147hydrogen peroxide catabolic process (GO:0042744)2.50433357
148dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.48720340
149heart looping (GO:0001947)2.48557311
150excretion (GO:0007588)2.47731093
151phenol-containing compound catabolic process (GO:0019336)2.44079063
152oligosaccharide biosynthetic process (GO:0009312)2.41490559
153calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.41434005
154polyol transport (GO:0015791)2.36153535
155sodium ion homeostasis (GO:0055078)2.35612998
156hypotonic response (GO:0006971)2.33259157
157water homeostasis (GO:0030104)2.32635299
158cilium or flagellum-dependent cell motility (GO:0001539)13.9443170
159axonemal dynein complex assembly (GO:0070286)12.8038695
160fusion of sperm to egg plasma membrane (GO:0007342)12.3849246
161epithelial cilium movement (GO:0003351)11.6225054
162sperm motility (GO:0030317)11.4350193
163cilium movement (GO:0003341)11.1714245
164acrosome assembly (GO:0001675)11.1084578
165sperm-egg recognition (GO:0035036)10.4779848
166epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)10.2997705
167motile cilium assembly (GO:0044458)10.2337458
168cell wall macromolecule metabolic process (GO:0044036)10.2285156
169cell wall macromolecule catabolic process (GO:0016998)10.2285156
170multicellular organism reproduction (GO:0032504)10.1615604

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.27548882
2EZH2_22144423_ChIP-Seq_EOC_Human5.52812589
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.57869715
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.45553621
5FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human3.41479801
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.26712472
7* DROSHA_22980978_ChIP-Seq_HELA_Human3.10311688
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.05633528
9TRIM28_21343339_ChIP-Seq_HEK293_Human2.72803197
10PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.68517098
11ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.56970271
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.46770408
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.34265991
14ESR1_20079471_ChIP-ChIP_T-47D_Human2.28781239
15GATA1_26923725_Chip-Seq_HPCs_Mouse2.19068688
16ZNF274_21170338_ChIP-Seq_K562_Hela2.18008946
17PCGF2_27294783_Chip-Seq_ESCs_Mouse2.04694790
18AHR_22903824_ChIP-Seq_MCF-7_Human1.96619433
19CBX2_27304074_Chip-Seq_ESCs_Mouse1.94950559
20EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.94271676
21PIAS1_25552417_ChIP-Seq_VCAP_Human1.92460537
22ESR2_21235772_ChIP-Seq_MCF-7_Human1.91147248
23ESR1_21235772_ChIP-Seq_MCF-7_Human1.90577443
24STAT6_21828071_ChIP-Seq_BEAS2B_Human1.88623761
25RBPJ_22232070_ChIP-Seq_NCS_Mouse1.87561702
26RUNX1_27514584_Chip-Seq_MCF-7_Human1.87385729
27KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.85249218
28CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.80880512
29TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.76959857
30RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.76666765
31NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.76301021
32* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.75457092
33SOX2_27498859_Chip-Seq_STOMACH_Mouse1.74702632
34ELK4_26923725_Chip-Seq_MESODERM_Mouse1.74427856
35SMC4_20622854_ChIP-Seq_HELA_Human1.71656047
36FOXM1_26456572_ChIP-Seq_MCF-7_Human1.69978266
37STAT1_20625510_ChIP-Seq_HELA_Human1.68019502
38* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.67804837
39PCGF2_27294783_Chip-Seq_NPCs_Mouse1.67556705
40VDR_22108803_ChIP-Seq_LS180_Human1.66932699
41GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.65980194
42ARNT_22903824_ChIP-Seq_MCF-7_Human1.65478592
43RNF2_27304074_Chip-Seq_NSC_Mouse1.64333514
44NR3C1_21868756_ChIP-Seq_MCF10A_Human1.59938890
45KAP1_22055183_ChIP-Seq_ESCs_Mouse1.59115438
46TP63_23658742_ChIP-Seq_EP156T_Human1.58593934
47CTBP2_25329375_ChIP-Seq_LNCAP_Human1.56954337
48AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.52021761
49ZNF217_24962896_ChIP-Seq_MCF-7_Human1.51831713
50* STAT1_17558387_ChIP-Seq_HELA_Human1.51471201
51CBP_20019798_ChIP-Seq_JUKART_Human1.49491171
52IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.49491171
53* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.49485841
54KLF5_25053715_ChIP-Seq_YYC3_Human1.47717074
55WDR5_24793694_ChIP-Seq_LNCAP_Human1.47471539
56ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.46823147
57NFE2_27457419_Chip-Seq_LIVER_Mouse1.46011083
58MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.45956612
59SOX9_24532713_ChIP-Seq_HFSC_Mouse1.45510489
60TAL1_26923725_Chip-Seq_HPCs_Mouse1.45478204
61SUZ12_27294783_Chip-Seq_NPCs_Mouse1.44236113
62SOX2_20726797_ChIP-Seq_SW620_Human1.42428414
63CTNNB1_20460455_ChIP-Seq_HCT116_Human1.41954761
64TP53_18474530_ChIP-ChIP_U2OS_Human1.41165651
65REST_21632747_ChIP-Seq_MESCs_Mouse1.40935440
66TP63_22573176_ChIP-Seq_HFKS_Human1.40515465
67CDX2_20551321_ChIP-Seq_CACO-2_Human1.40493241
68SOX2_22085726_ChIP-Seq_NPCs_Mouse1.40159885
69* GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.39967276
70TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.39786079
71KDM2B_26808549_Chip-Seq_REH_Human1.37498146
72TDRD3_21172665_ChIP-Seq_MCF-7_Human1.36950817
73GATA3_21867929_ChIP-Seq_CD8_Mouse1.36200528
74P63_26484246_Chip-Seq_KERATINOCYTES_Human1.35739644
75FOXA1_25552417_ChIP-Seq_VCAP_Human1.35431984
76CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.32477117
77FLI1_21867929_ChIP-Seq_TH2_Mouse1.32084992
78TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31947419
79POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.31947419
80ETV1_20927104_ChIP-Seq_GIST48_Human1.30690976
81CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.30594888
82SMRT_27268052_Chip-Seq_Bcells_Human1.28343448
83FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26156065
84HNFA_21074721_ChIP-Seq_CACO-2_Human1.24719602
85ZFP57_27257070_Chip-Seq_ESCs_Mouse1.24652364
86PHF8_20622853_ChIP-Seq_HELA_Human1.24601307
87GATA1_19941826_ChIP-Seq_K562_Human1.23830889
88NANOG_18555785_Chip-Seq_ESCs_Mouse1.22968082
89ELF1_20517297_ChIP-Seq_JURKAT_Human1.21556456
90EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.21260694
91PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.21199398
92TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20696484
93CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20385129
94SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.20286452
95TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.20173603
96CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.20090667
97GATA3_21867929_ChIP-Seq_TH1_Mouse1.18318981
98TAF15_26573619_Chip-Seq_HEK293_Human1.16850498
99SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.16444976
100CRX_20693478_ChIP-Seq_RETINA_Mouse1.15865420
101* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15812584
102* LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.15767422
103PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.14704422
104ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.14648062
105P53_21459846_ChIP-Seq_SAOS-2_Human1.13057243
106STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.12881632
107OCT4_18555785_Chip-Seq_ESCs_Mouse1.12632959
108CTCF_27219007_Chip-Seq_Bcells_Human1.11343054
109KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.10761793
110P53_22387025_ChIP-Seq_ESCs_Mouse1.10627969
111GATA4_25053715_ChIP-Seq_YYC3_Human1.09273322
112YY1_22570637_ChIP-Seq_MALME-3M_Human1.08502408
113CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.08287651
114CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.08264231
115P300_18555785_Chip-Seq_ESCs_Mouse1.08213449
116EZH2_27294783_Chip-Seq_ESCs_Mouse1.07095837
117KLF4_18555785_Chip-Seq_ESCs_Mouse1.07069386
118* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.05977672
119ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.05949970
120RBPJ_21746931_ChIP-Seq_IB4_Human1.05777142
121FOXO3_23340844_ChIP-Seq_DLD1_Human1.05008782
122MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.04821929
123CMYC_18555785_Chip-Seq_ESCs_Mouse1.03745879
124EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.03500062
125CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.03073708
126CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.02739221
127CTCF_20526341_ChIP-Seq_ESCs_Human1.02571554
128EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.02429761
129GATA3_24758297_ChIP-Seq_MCF-7_Human1.02420456
130EZH2_27294783_Chip-Seq_NPCs_Mouse1.01993816
131PPAR_26484153_Chip-Seq_NCI-H1993_Human1.01926999
132GF1_26923725_Chip-Seq_HPCs_Mouse1.01853290
133CBX2_22325352_ChIP-Seq_293T-Rex_Human1.01835908
134FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.01820177
135NFYA_21822215_ChIP-Seq_K562_Human1.01739412
136ERG_20517297_ChIP-Seq_VCAP_Human1.01737122
137PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.01624554
138GATA6_21074721_ChIP-Seq_CACO-2_Human1.00546487
139* RAD21_21589869_ChIP-Seq_MESCs_Mouse1.00306994
140RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.00296815
141STAT3_18555785_Chip-Seq_ESCs_Mouse1.00268482
142SMAD3_21741376_ChIP-Seq_HESCs_Human0.99730756
143ESRRB_18555785_Chip-Seq_ESCs_Mouse0.98650240
144SMAD4_21799915_ChIP-Seq_A2780_Human0.97521939
145SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.97484485
146PHF8_20622854_ChIP-Seq_HELA_Human0.97394423
147ER_23166858_ChIP-Seq_MCF-7_Human0.97326140
148SUZ12_18555785_Chip-Seq_ESCs_Mouse0.97238884
149OCT4_21477851_ChIP-Seq_ESCs_Mouse0.97217521
150AR_21572438_ChIP-Seq_LNCaP_Human0.96980756
151GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.96822785
152SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.96732780
153FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.96624440
154P68_20966046_ChIP-Seq_HELA_Human0.96077927
155ZNF263_19887448_ChIP-Seq_K562_Human0.95585995
156CEBPB_22108803_ChIP-Seq_LS180_Human0.95452988
157SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.95337933
158FOXA2_19822575_ChIP-Seq_HepG2_Human0.94698489
159FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94604427
160TBL1_22424771_ChIP-Seq_293T_Human0.94578345
161GF1B_26923725_Chip-Seq_HPCs_Mouse0.94327027
162CREB1_26743006_Chip-Seq_LNCaP_Human0.93688346
163TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.93685107
164NFYB_21822215_ChIP-Seq_K562_Human0.92807063
165SOX9_26525672_Chip-Seq_HEART_Mouse0.91779371
166SOX2_18555785_Chip-Seq_ESCs_Mouse0.91706450
167PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.90559393
168BCAT_22108803_ChIP-Seq_LS180_Human0.89239429
169ZFX_18555785_Chip-Seq_ESCs_Mouse0.88405030
170BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.88211729
171RUNX1_26923725_Chip-Seq_HPCs_Mouse0.88148985
172EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.88091219
173RUNX1_27457419_Chip-Seq_LIVER_Mouse0.88003727
174E2F1_18555785_Chip-Seq_ESCs_Mouse0.87925881
175SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.87635686
176SOX2_21211035_ChIP-Seq_LN229_Human0.87597349
177TP53_16413492_ChIP-PET_HCT116_Human0.87468772
178SMAD4_21741376_ChIP-Seq_EPCs_Human0.86999799
179PU1_27457419_Chip-Seq_LIVER_Mouse0.86642202
180CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.86356095
181ESET_19884257_ChIP-Seq_ESCs_Mouse0.86136082
182STAT3_18555785_ChIP-Seq_MESCs_Mouse0.86125571
183CTCF_18555785_Chip-Seq_ESCs_Mouse0.86082603
184SPI1_26923725_Chip-Seq_HPCs_Mouse0.85728511
185TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.84589951
186FLI1_21867929_ChIP-Seq_CD8_Mouse0.84343259
187TCF4_22108803_ChIP-Seq_LS180_Human0.84112887
188RACK7_27058665_Chip-Seq_MCF-7_Human0.83314741
189P300_27268052_Chip-Seq_Bcells_Human0.82927591

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008875_abnormal_xenobiotic_pharmacok6.85846979
2MP0003698_abnormal_male_reproductive5.67837571
3MP0001929_abnormal_gametogenesis5.19071111
4MP0008877_abnormal_DNA_methylation4.96918850
5MP0002653_abnormal_ependyma_morphology3.93115028
6MP0002277_abnormal_respiratory_mucosa3.90364252
7MP0004043_abnormal_pH_regulation3.68365714
8MP0002210_abnormal_sex_determination3.51332088
9MP0009780_abnormal_chondrocyte_physiolo3.40420487
10MP0008789_abnormal_olfactory_epithelium3.22772423
11MP0002161_abnormal_fertility/fecundity3.04793116
12MP0001145_abnormal_male_reproductive2.92998837
13MP0000566_synostosis2.80223410
14MP0005623_abnormal_meninges_morphology2.65179973
15MP0000653_abnormal_sex_gland2.55601209
16MP0000383_abnormal_hair_follicle2.46826514
17MP0002160_abnormal_reproductive_system2.32554291
18MP0005394_taste/olfaction_phenotype2.14452082
19MP0005499_abnormal_olfactory_system2.14452082
20MP0004019_abnormal_vitamin_homeostasis2.14311454
21MP0010678_abnormal_skin_adnexa2.09643272
22MP0001984_abnormal_olfaction2.02859694
23MP0005410_abnormal_fertilization14.1421131
24MP0002168_other_aberrant_phenotype1.82530980
25MP0005083_abnormal_biliary_tract1.80243364
26MP0002282_abnormal_trachea_morphology1.78198132
27MP0009046_muscle_twitch1.72982738
28MP0003656_abnormal_erythrocyte_physiolo1.72075462
29MP0008057_abnormal_DNA_replication1.68251065
30MP0005670_abnormal_white_adipose1.54512668
31MP0003646_muscle_fatigue1.48510104
32MP0002909_abnormal_adrenal_gland1.43420187
33MP0001346_abnormal_lacrimal_gland1.38389148
34MP0009379_abnormal_foot_pigmentation1.36487082
35MP0000678_abnormal_parathyroid_gland1.35694801
36MP0005389_reproductive_system_phenotype1.32449457
37MP0005165_increased_susceptibility_to1.29567375
38MP0008995_early_reproductive_senescence1.27769269
39MP0008058_abnormal_DNA_repair1.26368124
40MP0010030_abnormal_orbit_morphology1.24008952
41MP0004133_heterotaxia1.21204718
42MP0002734_abnormal_mechanical_nocicepti1.19854971
43MP0002638_abnormal_pupillary_reflex1.17758334
44MP0005248_abnormal_Harderian_gland1.16492549
45MP0001485_abnormal_pinna_reflex1.16155103
46MP0005395_other_phenotype1.11060610
47MP0004233_abnormal_muscle_weight1.10689426
48MP0000465_gastrointestinal_hemorrhage1.07440196
49MP0005377_hearing/vestibular/ear_phenot1.05176411
50MP0003878_abnormal_ear_physiology1.05176411
51MP0010234_abnormal_vibrissa_follicle1.04600239
52MP0002102_abnormal_ear_morphology1.02292481
53MP0010155_abnormal_intestine_physiology0.99787735
54MP0005647_abnormal_sex_gland0.99302632
55MP0001765_abnormal_ion_homeostasis0.92436904
56MP0002234_abnormal_pharynx_morphology0.92256062
57MP0003011_delayed_dark_adaptation0.90796879
58MP0002132_abnormal_respiratory_system0.90687176
59MP0005164_abnormal_response_to0.88673894
60MP0002735_abnormal_chemical_nociception0.85498643
61MP0002876_abnormal_thyroid_physiology0.84757845
62MP0004883_abnormal_blood_vessel0.83167668
63MP0000026_abnormal_inner_ear0.83083330
64MP0000467_abnormal_esophagus_morphology0.80222678
65MP0006072_abnormal_retinal_apoptosis0.79099506
66MP0005551_abnormal_eye_electrophysiolog0.78805368
67MP0005503_abnormal_tendon_morphology0.78511341
68MP0005365_abnormal_bile_salt0.77638121
69MP0005253_abnormal_eye_physiology0.77430241
70MP0004264_abnormal_extraembryonic_tissu0.76510151
71MP0003786_premature_aging0.76068679
72MP0003136_yellow_coat_color0.74775881
73MP0002098_abnormal_vibrissa_morphology0.74649743
74MP0001849_ear_inflammation0.74426485
75MP0003115_abnormal_respiratory_system0.74408196
76MP0005646_abnormal_pituitary_gland0.74059500
77MP0001270_distended_abdomen0.73118611
78MP0009643_abnormal_urine_homeostasis0.73083925
79MP0010094_abnormal_chromosome_stability0.72545136
80MP0002136_abnormal_kidney_physiology0.70447251
81MP0001293_anophthalmia0.70232274
82MP0003453_abnormal_keratinocyte_physiol0.68899621
83MP0000681_abnormal_thyroid_gland0.67818645
84MP0002139_abnormal_hepatobiliary_system0.66620672
85MP0003303_peritoneal_inflammation0.65896494
86MP0002928_abnormal_bile_duct0.65296630
87MP0005085_abnormal_gallbladder_physiolo0.64787504
88MP0003942_abnormal_urinary_system0.64776473
89MP0001299_abnormal_eye_distance/0.64767057
90MP0003122_maternal_imprinting0.63958563
91MP0005220_abnormal_exocrine_pancreas0.63925706
92MP0005408_hypopigmentation0.63219746
93MP0001440_abnormal_grooming_behavior0.62756623
94MP0005391_vision/eye_phenotype0.60407379
95MP0009765_abnormal_xenobiotic_induced0.59961943
96MP0003861_abnormal_nervous_system0.58780068
97MP0001502_abnormal_circadian_rhythm0.58268267
98MP0009703_decreased_birth_body0.58207401
99MP0004134_abnormal_chest_morphology0.57536585
100MP0002896_abnormal_bone_mineralization0.56064801
101MP0003075_altered_response_to0.56018336
102MP0002152_abnormal_brain_morphology0.55744562
103MP0002405_respiratory_system_inflammati0.53779578
104MP0002736_abnormal_nociception_after0.52329694
105MP0000631_abnormal_neuroendocrine_gland0.51752842
106MP0001963_abnormal_hearing_physiology0.50676072
107MP0003938_abnormal_ear_development0.50509259
108MP0004885_abnormal_endolymph0.50412917
109MP0009763_increased_sensitivity_to0.50132130
110MP0001944_abnormal_pancreas_morphology0.49306600
111MP0003890_abnormal_embryonic-extraembry0.48406216
112MP0003937_abnormal_limbs/digits/tail_de0.47808044
113MP0000778_abnormal_nervous_system0.47735000
114MP0005310_abnormal_salivary_gland0.47201891
115MP0008007_abnormal_cellular_replicative0.46817964
116MP0003950_abnormal_plasma_membrane0.45960187
117MP0003866_abnormal_defecation0.45867173
118MP0000358_abnormal_cell_content/0.45544021
119MP0000534_abnormal_ureter_morphology0.45537717
120MP0005423_abnormal_somatic_nervous0.45235226
121MP0001664_abnormal_digestion0.44734183
122MP0002572_abnormal_emotion/affect_behav0.44506092
123MP0001970_abnormal_pain_threshold0.44435614
124MP0001968_abnormal_touch/_nociception0.43440029
125MP0001663_abnormal_digestive_system0.43194394
126MP0003787_abnormal_imprinting0.42090104
127MP0005195_abnormal_posterior_eye0.41566900
128MP0000049_abnormal_middle_ear0.41537910
129MP0005636_abnormal_mineral_homeostasis0.41218235
130MP0002557_abnormal_social/conspecific_i0.41051157
131MP0009250_abnormal_appendicular_skeleto0.40290822
132MP0004036_abnormal_muscle_relaxation0.39728754
133MP0001324_abnormal_eye_pigmentation0.39543534
134MP0003699_abnormal_female_reproductive0.38582056
135MP0005645_abnormal_hypothalamus_physiol0.38348201
136MP0002249_abnormal_larynx_morphology0.37981164
137MP0002752_abnormal_somatic_nervous0.37565186
138MP0001119_abnormal_female_reproductive0.37268415
139MP0003634_abnormal_glial_cell0.35640675
140MP0002272_abnormal_nervous_system0.35161792
141MP0004145_abnormal_muscle_electrophysio0.35139069
142MP0003879_abnormal_hair_cell0.35011294
143MP0002092_abnormal_eye_morphology0.35008033
144MP0003121_genomic_imprinting0.34912937
145MP0001545_abnormal_hematopoietic_system0.34620208
146MP0005397_hematopoietic_system_phenotyp0.34620208
147MP0001919_abnormal_reproductive_system0.34044249
148MP0001727_abnormal_embryo_implantation0.33894068
149MP0000955_abnormal_spinal_cord0.33610867
150MP0003283_abnormal_digestive_organ0.33491274
151MP0000432_abnormal_head_morphology0.33467433
152MP0006035_abnormal_mitochondrial_morpho0.32746866
153MP0002133_abnormal_respiratory_system0.32191080
154MP0005388_respiratory_system_phenotype0.32191080
155MP0006036_abnormal_mitochondrial_physio0.31959874
156MP0002084_abnormal_developmental_patter0.31819996
157MP0004811_abnormal_neuron_physiology0.31733610
158MP0002233_abnormal_nose_morphology0.31700917
159MP0002882_abnormal_neuron_morphology0.30781277
160MP0002116_abnormal_craniofacial_bone0.30017196
161MP0002064_seizures0.29581285
162MP0003635_abnormal_synaptic_transmissio0.29445517
163MP0001529_abnormal_vocalization0.29263391
164MP0009745_abnormal_behavioral_response0.28831397
165MP0003633_abnormal_nervous_system0.28760547
166MP0002295_abnormal_pulmonary_circulatio0.28517730
167MP0003880_abnormal_central_pattern0.28203588
168MP0003948_abnormal_gas_homeostasis0.28202150

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory epithelium morphology (HP:0012253)9.72607243
2Abnormal respiratory motile cilium morphology (HP:0005938)9.72607243
3Abnormal ciliary motility (HP:0012262)9.62411084
4Rhinitis (HP:0012384)9.01366138
5Chronic bronchitis (HP:0004469)7.53548306
6Nasal polyposis (HP:0100582)5.73566124
7Infertility (HP:0000789)5.54903696
8Bronchiectasis (HP:0002110)5.20349411
9Abnormality of the nasal mucosa (HP:0000433)4.72044732
10Nephronophthisis (HP:0000090)4.48822312
11Bronchitis (HP:0012387)4.27526214
12Recurrent sinusitis (HP:0011108)3.56015407
13Abnormality of the renal medulla (HP:0100957)3.46382640
14Abnormality of midbrain morphology (HP:0002418)3.29278495
15Molar tooth sign on MRI (HP:0002419)3.29278495
16Medial flaring of the eyebrow (HP:0010747)3.14261312
17Recurrent otitis media (HP:0000403)3.12524487
18Atelectasis (HP:0100750)3.07347054
19Chronic otitis media (HP:0000389)3.03784010
20Tubulointerstitial nephritis (HP:0001970)2.98357759
21Male infertility (HP:0003251)2.94583053
22Hyperactive renin-angiotensin system (HP:0000841)2.86093828
23Chronic sinusitis (HP:0011109)2.70614860
24Pancreatic fibrosis (HP:0100732)2.63793220
25Tubular atrophy (HP:0000092)2.59093559
26Tubulointerstitial abnormality (HP:0001969)2.47995673
27True hermaphroditism (HP:0010459)2.37065582
28Postaxial foot polydactyly (HP:0001830)2.34970861
29Gait imbalance (HP:0002141)2.29204965
30Congenital hepatic fibrosis (HP:0002612)2.28992388
31Congenital primary aphakia (HP:0007707)2.27770773
32Abnormal spermatogenesis (HP:0008669)2.23535921
33Median cleft lip (HP:0000161)2.21067205
34Abnormality of the lower motor neuron (HP:0002366)2.20116446
35Fibular hypoplasia (HP:0003038)2.18317078
36Stage 5 chronic kidney disease (HP:0003774)2.18273908
37Supernumerary spleens (HP:0009799)2.14654804
38Recurrent bronchitis (HP:0002837)2.10178153
39Cystic liver disease (HP:0006706)2.07253596
40Gonadotropin excess (HP:0000837)2.06912426
41Tubulointerstitial fibrosis (HP:0005576)2.04691109
42Abnormality of dentin (HP:0010299)2.01687480
43Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.5579900
44Absent/shortened dynein arms (HP:0200106)11.9605029
45Dynein arm defect of respiratory motile cilia (HP:0012255)11.9605029
46Abnormal respiratory motile cilium physiology (HP:0012261)10.8148874
47Nephrogenic diabetes insipidus (HP:0009806)1.99716603
48Abnormality of permanent molar morphology (HP:0011071)1.98133329
49Abnormality of the dental root (HP:0006486)1.98133329
50Taurodontia (HP:0000679)1.98133329
51Oculomotor apraxia (HP:0000657)1.93737913
52Facial cleft (HP:0002006)1.92519995
53Aplasia/Hypoplasia of the tongue (HP:0010295)1.91825538
54Postaxial hand polydactyly (HP:0001162)1.88807858
55Abnormality of molar (HP:0011077)1.83320945
56Abnormality of molar morphology (HP:0011070)1.83320945
57Pancreatic cysts (HP:0001737)1.81902016
58Genital tract atresia (HP:0001827)1.80500591
59Abnormality of the dental pulp (HP:0006479)1.77724999
60Decreased circulating renin level (HP:0003351)1.74825308
61Furrowed tongue (HP:0000221)1.74657310
62Vaginal atresia (HP:0000148)1.74321991
63Abnormal drinking behavior (HP:0030082)1.73972173
64Polydipsia (HP:0001959)1.73972173
65Renal salt wasting (HP:0000127)1.73599185
66Abnormality of the renal cortex (HP:0011035)1.70073256
67Occipital encephalocele (HP:0002085)1.69189453
68Asplenia (HP:0001746)1.68564467
69Poor coordination (HP:0002370)1.68129215
70Aplasia/Hypoplasia of the spleen (HP:0010451)1.68057156
71Aplasia/Hypoplasia of the lens (HP:0008063)1.62337917
72Impulsivity (HP:0100710)1.61730566
73Renal dysplasia (HP:0000110)1.59246444
74Amyotrophic lateral sclerosis (HP:0007354)1.59185432
75Short ribs (HP:0000773)1.57124701
76Azoospermia (HP:0000027)1.54075140
77Microglossia (HP:0000171)1.52943174
78Bile duct proliferation (HP:0001408)1.52394494
79Abnormal biliary tract physiology (HP:0012439)1.52394494
80Hyperkalemia (HP:0002153)1.50556454
81Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.48500028
82Bell-shaped thorax (HP:0001591)1.44705479
83Abnormality of renal excretion (HP:0011036)1.44553993
84Hyperaldosteronism (HP:0000859)1.42802651
85Aplasia/Hypoplasia of the fibula (HP:0006492)1.38431979
86Short nail (HP:0001799)1.37826944
87Decreased central vision (HP:0007663)1.37733465
88Preaxial hand polydactyly (HP:0001177)1.36940695
89Impaired proprioception (HP:0010831)1.36642631
90Anencephaly (HP:0002323)1.31464896
91Abnormality of renin-angiotensin system (HP:0000847)1.30441151
92Chronic hepatic failure (HP:0100626)1.29103040
93Sclerocornea (HP:0000647)1.28082703
94Nephropathy (HP:0000112)1.27478433
95Bifid tongue (HP:0010297)1.26667890
96Hypoplasia of the capital femoral epiphysis (HP:0003090)1.25667367
9711 pairs of ribs (HP:0000878)1.25635025
98Abnormality of chloride homeostasis (HP:0011422)1.23241291
99Short thorax (HP:0010306)1.23204891
100Dyschromatopsia (HP:0007641)1.22619274
101Absent frontal sinuses (HP:0002688)1.21479048
102Abnormality of the frontal sinuses (HP:0002687)1.20279040
103Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.18926342
104Male pseudohermaphroditism (HP:0000037)1.18775872
105Abdominal situs inversus (HP:0003363)1.18410146
106Abnormality of abdominal situs (HP:0011620)1.18410146
107Bifid scrotum (HP:0000048)1.18090599
108Hypokalemic alkalosis (HP:0001949)1.17354235
109Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.17331189
110Absent rod-and cone-mediated responses on ERG (HP:0007688)1.17204569
111J-shaped sella turcica (HP:0002680)1.12955340
112Abnormality of the distal phalanges of the toes (HP:0010182)1.12762665
113Abnormal urine output (HP:0012590)1.12486854
114Glucose intolerance (HP:0000833)1.11305280
115Broad distal phalanx of finger (HP:0009836)1.10791257
116Cholecystitis (HP:0001082)1.09329850
117Abnormal gallbladder physiology (HP:0012438)1.09329850
118Cone-rod dystrophy (HP:0000548)1.07001025
119Retinitis pigmentosa (HP:0000510)1.06781632
120Hyponatremia (HP:0002902)1.04781341
121Abnormality of ocular smooth pursuit (HP:0000617)1.04213644
122Specific learning disability (HP:0001328)1.03800781
123Hand muscle atrophy (HP:0009130)1.03692640
124Fetal akinesia sequence (HP:0001989)1.00468748
125Short femoral neck (HP:0100864)0.98938074
126Muscle fiber splitting (HP:0003555)0.98066454
127Aplasia of the musculature (HP:0100854)0.95881573
128Popliteal pterygium (HP:0009756)0.93536690
129Obstructive sleep apnea (HP:0002870)0.91736732

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK48.71595279
2PDK38.71595279
3PDK25.60817373
4TESK14.50410388
5EPHA24.40751770
6PRKD33.62420194
7PNCK3.21170878
8ICK3.04575714
9MAPK152.79860529
10PTK2B2.46645587
11MAPKAPK32.37500727
12STK392.10640759
13WNK42.10522543
14NME11.94483086
15MAP3K21.90355479
16STK241.81310970
17SMG11.73965631
18TSSK61.65090699
19NEK21.63912428
20STK381.45223410
21MAP3K31.43422133
22BCR1.41305150
23CSK1.38776744
24EPHB11.30491658
25EPHA31.14283899
26LRRK21.13291756
27DYRK1B1.05854211
28WEE11.04276585
29DYRK30.96068479
30TLK10.93606698
31TYRO30.91206820
32MAP3K70.90540593
33MST1R0.88077424
34RIPK40.87023528
35LMTK20.83600071
36TTK0.82415424
37TRPM70.82242748
38PLK40.81445699
39PASK0.79963837
40PDK10.78731737
41WNK10.77254838
42IRAK10.76599185
43NTRK20.75981847
44ERBB30.70229194
45PRKCI0.70174384
46TBK10.69177054
47CCNB10.67973126
48CDC70.66073878
49STK30.65251864
50ERBB20.64371084
51MAP3K120.61216577
52STK38L0.59022969
53CHEK20.57589401
54BRSK20.51818087
55PRKCG0.46769570
56PINK10.45388519
57NLK0.44904693
58NEK60.42982361
59CHEK10.42266022
60PRKCD0.41725931
61NEK90.39557094
62MAP2K70.39259122
63RPS6KB20.39217832
64GRK60.37883816
65MAP2K60.37645540
66CAMK1G0.37572543
67MAP3K40.36254873
68PAK20.36091681
69PLK10.35106699
70IRAK20.34970621
71CDK30.34146305
72STK160.34046610
73ATM0.33349795
74ATR0.33299269
75SGK10.32437288
76LATS10.31845186
77AURKA0.29553434
78MAP2K20.29517296
79EPHA40.29452928
80TRIB30.28985802
81PAK10.28930570
82ROCK20.28584373
83TESK20.28441665
84MUSK0.28174065
85PDPK10.27357146
86PRKAA20.26589154
87MET0.26133896
88PBK0.26061910
89MARK10.25619308
90HIPK20.25288799
91INSRR0.25122300
92TAOK10.25074555
93BRAF0.24787418
94RIPK10.24046505
95DYRK1A0.23939271
96ABL10.23094481
97RET0.22862940
98ROCK10.22068770
99FER0.22066285
100ADRBK10.20712114
101MAPKAPK50.20646709
102FGFR30.20557029
103RPS6KB10.20349588
104AKT20.19690734
105GRK10.19518467
106GRK70.19274952
107CAMKK10.19194751
108CDC42BPA0.18249511
109PTK60.18224509
110EEF2K0.17453361
111PRKCA0.17425176
112PHKG10.16280750
113PHKG20.16280750
114BRSK10.15949301
115MINK10.15802903
116PRKAA10.15353145
117CAMK2A0.14632974
118FYN0.14631226
119SRC0.14460715
120MTOR0.14387056
121PRKG10.13909585
122CSNK2A10.13468430
123MAPK130.11997224
124PIM20.11804275
125RPS6KA20.11291494
126PRKACG0.10773852
127STK100.10190588
128MAPK100.10110787
129EGFR0.09785880
130PRKCZ0.09464051
131PRKACA0.08492063
132CAMKK20.08345912
133CDK60.08123013
134ARAF0.07938822
135PRKDC0.07776327
136CSNK2A20.07668265
137DDR20.07180702
138CSNK1E0.06983440
139GSK3B0.06950342
140MARK20.06939105
141YES10.06897626
142MST40.06306577
143CDK10.05939009
144CDK150.05385417
145MAP2K40.05363037
146PAK60.05036371
147WNK30.04824036
148GRK50.04812386
149GSK3A0.04733490
150MAPK80.04677482
151STK110.04631557
152CDK180.04619697
153CAMK2G0.04497182
154CDK20.04113577
155RPS6KA10.04019397
156PRKACB0.03979164
157PRKCQ0.03841602
158PKN10.03796576
159PLK30.03654928
160PAK40.03106602
161VRK10.02903846

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007505.26022584
2Phenylalanine metabolism_Homo sapiens_hsa003605.11544210
3Histidine metabolism_Homo sapiens_hsa003404.69524399
4Pyruvate metabolism_Homo sapiens_hsa006204.03025485
5Tyrosine metabolism_Homo sapiens_hsa003503.97508065
6Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.87145179
7Propanoate metabolism_Homo sapiens_hsa006403.19674939
8beta-Alanine metabolism_Homo sapiens_hsa004103.04467451
9Fatty acid biosynthesis_Homo sapiens_hsa000612.95287007
10Basal transcription factors_Homo sapiens_hsa030222.88951965
11Huntingtons disease_Homo sapiens_hsa050162.83153223
12Glucagon signaling pathway_Homo sapiens_hsa049222.67759907
13Retinol metabolism_Homo sapiens_hsa008302.30082797
14Caffeine metabolism_Homo sapiens_hsa002322.28876113
15Linoleic acid metabolism_Homo sapiens_hsa005912.13173806
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.11311195
17Oocyte meiosis_Homo sapiens_hsa041142.00314248
18Fanconi anemia pathway_Homo sapiens_hsa034601.95038049
19Pentose phosphate pathway_Homo sapiens_hsa000301.93791867
20Amphetamine addiction_Homo sapiens_hsa050311.92351667
21Cardiac muscle contraction_Homo sapiens_hsa042601.79906708
22Dorso-ventral axis formation_Homo sapiens_hsa043201.72670844
23Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.64580970
24Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.58778769
25Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.58190680
26Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.54091743
27Sphingolipid metabolism_Homo sapiens_hsa006001.51395862
28Selenocompound metabolism_Homo sapiens_hsa004501.49704474
29Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.47955004
30Glycerolipid metabolism_Homo sapiens_hsa005611.47218219
31Renin secretion_Homo sapiens_hsa049241.45295557
32Tight junction_Homo sapiens_hsa045301.44998961
33Steroid hormone biosynthesis_Homo sapiens_hsa001401.44014091
34Glycosaminoglycan degradation_Homo sapiens_hsa005311.40562008
35Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.38464887
36Purine metabolism_Homo sapiens_hsa002301.33284308
37Olfactory transduction_Homo sapiens_hsa047401.31507554
38PPAR signaling pathway_Homo sapiens_hsa033201.30802215
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.26283529
40Glycerophospholipid metabolism_Homo sapiens_hsa005641.21883878
41Ether lipid metabolism_Homo sapiens_hsa005651.21532452
42Carbohydrate digestion and absorption_Homo sapiens_hsa049731.20716677
43Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.14082355
44Carbon metabolism_Homo sapiens_hsa012001.12914175
45mRNA surveillance pathway_Homo sapiens_hsa030151.11002165
46Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.10927590
47Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.08802967
48Peroxisome_Homo sapiens_hsa041461.07551117
49Collecting duct acid secretion_Homo sapiens_hsa049661.06425124
50Glutathione metabolism_Homo sapiens_hsa004801.05517628
51Fructose and mannose metabolism_Homo sapiens_hsa000511.04979864
52Mineral absorption_Homo sapiens_hsa049781.02974956
53RNA transport_Homo sapiens_hsa030131.02837765
54Oxidative phosphorylation_Homo sapiens_hsa001901.00760419
55Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.99732843
56Long-term potentiation_Homo sapiens_hsa047200.96283319
57Notch signaling pathway_Homo sapiens_hsa043300.95792126
58Calcium signaling pathway_Homo sapiens_hsa040200.94563568
59Hedgehog signaling pathway_Homo sapiens_hsa043400.93034541
60Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.92504348
61Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.87631362
62Taste transduction_Homo sapiens_hsa047420.86761410
63Starch and sucrose metabolism_Homo sapiens_hsa005000.86582820
64Arachidonic acid metabolism_Homo sapiens_hsa005900.85788484
65Insulin secretion_Homo sapiens_hsa049110.82297146
66Chemical carcinogenesis_Homo sapiens_hsa052040.82242365
67Estrogen signaling pathway_Homo sapiens_hsa049150.80904320
68Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.80373579
69Parkinsons disease_Homo sapiens_hsa050120.78933090
70Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.78903809
71Alzheimers disease_Homo sapiens_hsa050100.78511513
72Circadian rhythm_Homo sapiens_hsa047100.76154396
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.74497022
74Leukocyte transendothelial migration_Homo sapiens_hsa046700.72234385
75Nicotine addiction_Homo sapiens_hsa050330.71875886
76Thyroid hormone synthesis_Homo sapiens_hsa049180.70393146
77Choline metabolism in cancer_Homo sapiens_hsa052310.69746946
78Biosynthesis of amino acids_Homo sapiens_hsa012300.68231811
79Fat digestion and absorption_Homo sapiens_hsa049750.68009885
80cGMP-PKG signaling pathway_Homo sapiens_hsa040220.65885807
81Antigen processing and presentation_Homo sapiens_hsa046120.65041503
82Synaptic vesicle cycle_Homo sapiens_hsa047210.64359527
83Drug metabolism - other enzymes_Homo sapiens_hsa009830.64278873
84Primary bile acid biosynthesis_Homo sapiens_hsa001200.63977576
85Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.63238561
86Pyrimidine metabolism_Homo sapiens_hsa002400.61588016
87Hepatitis C_Homo sapiens_hsa051600.61234547
88Systemic lupus erythematosus_Homo sapiens_hsa053220.60732043
89Gastric acid secretion_Homo sapiens_hsa049710.60364796
90Basal cell carcinoma_Homo sapiens_hsa052170.59718047
91Circadian entrainment_Homo sapiens_hsa047130.57252357
92Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.56940393
93Adherens junction_Homo sapiens_hsa045200.56743717
94Pentose and glucuronate interconversions_Homo sapiens_hsa000400.54839787
95Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.54362977
96Salivary secretion_Homo sapiens_hsa049700.54214323
97Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53936738
98Complement and coagulation cascades_Homo sapiens_hsa046100.51187998
99Alcoholism_Homo sapiens_hsa050340.50922096
100Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.50867107
101Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.49996278
102Cocaine addiction_Homo sapiens_hsa050300.49956727
103Wnt signaling pathway_Homo sapiens_hsa043100.49230866
104Fatty acid metabolism_Homo sapiens_hsa012120.48639264
105Metabolic pathways_Homo sapiens_hsa011000.48061381
106Glutamatergic synapse_Homo sapiens_hsa047240.46522563
107Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.45896208
108Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.45011098
109Homologous recombination_Homo sapiens_hsa034400.44154767
110Fatty acid degradation_Homo sapiens_hsa000710.43925460
111Renin-angiotensin system_Homo sapiens_hsa046140.43912245
112Vascular smooth muscle contraction_Homo sapiens_hsa042700.41880123
113Inositol phosphate metabolism_Homo sapiens_hsa005620.40364210
114Hippo signaling pathway_Homo sapiens_hsa043900.39596251
115cAMP signaling pathway_Homo sapiens_hsa040240.38179610
116Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.38012043
117Hematopoietic cell lineage_Homo sapiens_hsa046400.37959730
118AMPK signaling pathway_Homo sapiens_hsa041520.37749780
119Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.37623964
120Phosphatidylinositol signaling system_Homo sapiens_hsa040700.36414959
121Transcriptional misregulation in cancer_Homo sapiens_hsa052020.35471120
122Phototransduction_Homo sapiens_hsa047440.35163415
123Central carbon metabolism in cancer_Homo sapiens_hsa052300.33918926
124Nucleotide excision repair_Homo sapiens_hsa034200.33846510
125Bile secretion_Homo sapiens_hsa049760.33153546
126Proteasome_Homo sapiens_hsa030500.33070261
127Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.31522220
128Adipocytokine signaling pathway_Homo sapiens_hsa049200.31499131
129Dopaminergic synapse_Homo sapiens_hsa047280.31189256
130Amoebiasis_Homo sapiens_hsa051460.30810257
131ABC transporters_Homo sapiens_hsa020100.29517344
132RNA degradation_Homo sapiens_hsa030180.29349567
133Arginine and proline metabolism_Homo sapiens_hsa003300.29293613
134Pancreatic secretion_Homo sapiens_hsa049720.28401102
135Cell cycle_Homo sapiens_hsa041100.27839642
136Sulfur metabolism_Homo sapiens_hsa009200.27829770
137Axon guidance_Homo sapiens_hsa043600.25277583
138Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.22293744
139Nitrogen metabolism_Homo sapiens_hsa009100.20653424
140Serotonergic synapse_Homo sapiens_hsa047260.20508582
141Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.20150247
142Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.20065057
143Vitamin digestion and absorption_Homo sapiens_hsa049770.19636167
144Cyanoamino acid metabolism_Homo sapiens_hsa004600.19289317
145Lysosome_Homo sapiens_hsa041420.18533841
146Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.17141979
147Melanogenesis_Homo sapiens_hsa049160.15658793
148Tryptophan metabolism_Homo sapiens_hsa003800.15381091
149Sphingolipid signaling pathway_Homo sapiens_hsa040710.15295473
150Type I diabetes mellitus_Homo sapiens_hsa049400.14495775
151Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.12425458
152Insulin resistance_Homo sapiens_hsa049310.10834499
153Phagosome_Homo sapiens_hsa041450.10818829
154Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.10094018
155Dilated cardiomyopathy_Homo sapiens_hsa054140.08725014
156Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.08187961
157Jak-STAT signaling pathway_Homo sapiens_hsa046300.07810998
158Prostate cancer_Homo sapiens_hsa052150.06740535
159Allograft rejection_Homo sapiens_hsa053300.06421376
160Endocytosis_Homo sapiens_hsa041440.04431934

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