TEKT2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene product belongs to the tektin family of proteins. Tektins comprise a family of filament-forming proteins that are coassembled with tubulins to form ciliary and flagellar microtubules. This gene is expressed in the testis and its protein is localized to the flagella of the sperms, indicating that it may play a role in spermatogenesis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1motile cilium assembly (GO:0044458)9.52923113
2acrosome assembly (GO:0001675)9.39953293
3plasma membrane fusion (GO:0045026)9.39360952
4regulation of cilium movement (GO:0003352)9.35331843
5cilium movement (GO:0003341)9.25786286
6binding of sperm to zona pellucida (GO:0007339)9.25604338
7cell wall macromolecule catabolic process (GO:0016998)9.24298538
8cell wall macromolecule metabolic process (GO:0044036)9.24298538
9spermatid development (GO:0007286)9.13846078
10cell-cell recognition (GO:0009988)9.01728572
11piRNA metabolic process (GO:0034587)8.84770908
12reproduction (GO:0000003)8.50522227
13epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.41115461
14male meiosis (GO:0007140)7.82428646
15synaptonemal complex organization (GO:0070193)7.56391693
16synaptonemal complex assembly (GO:0007130)7.17549087
17single fertilization (GO:0007338)7.11781634
18sperm capacitation (GO:0048240)6.67818141
19negative regulation of inclusion body assembly (GO:0090084)6.27855787
20microtubule depolymerization (GO:0007019)6.08884534
21male meiosis I (GO:0007141)6.06790909
22microtubule bundle formation (GO:0001578)6.04788075
23fertilization (GO:0009566)6.03930458
24spermatogenesis (GO:0007283)5.88339280
25male gamete generation (GO:0048232)5.86221714
26regulation of microtubule-based movement (GO:0060632)5.73821322
27DNA methylation involved in gamete generation (GO:0043046)5.65049090
28ventricular system development (GO:0021591)5.57499891
29gamete generation (GO:0007276)5.42205365
30regulation of inclusion body assembly (GO:0090083)5.15761731
31germ cell development (GO:0007281)5.13253813
32meiosis I (GO:0007127)5.11043848
33organic cation transport (GO:0015695)5.09156590
34microtubule severing (GO:0051013)5.02027233
35cellular process involved in reproduction in multicellular organism (GO:0022412)5.01718437
36meiotic nuclear division (GO:0007126)4.91547566
37chromosome organization involved in meiosis (GO:0070192)4.84784048
38calcium ion-dependent exocytosis (GO:0017156)4.74823112
39left/right pattern formation (GO:0060972)4.63230410
40cell recognition (GO:0008037)4.36437468
41primary alcohol catabolic process (GO:0034310)4.34561607
42multicellular organismal reproductive process (GO:0048609)4.29323375
43axoneme assembly (GO:0035082)4.26175214
44seminiferous tubule development (GO:0072520)4.20853455
45one-carbon compound transport (GO:0019755)4.16922476
46cell projection assembly (GO:0030031)4.11099781
47protein localization to cilium (GO:0061512)4.07811063
48meiotic cell cycle (GO:0051321)4.06393490
49intraciliary transport (GO:0042073)4.01584371
50protein polyglutamylation (GO:0018095)4.00670206
51vitamin transmembrane transport (GO:0035461)3.95617449
52ethanol metabolic process (GO:0006067)3.84643333
53establishment or maintenance of monopolar cell polarity (GO:0061339)3.82963053
54establishment of monopolar cell polarity (GO:0061162)3.82963053
55glycerol ether metabolic process (GO:0006662)3.81665126
56monoubiquitinated protein deubiquitination (GO:0035520)3.80535911
57response to xenobiotic stimulus (GO:0009410)3.80043318
58genitalia morphogenesis (GO:0035112)3.78861408
59negative regulation of T cell differentiation in thymus (GO:0033085)3.75142594
60response to pheromone (GO:0019236)3.71209801
61spermatid nucleus differentiation (GO:0007289)3.68279096
62nucleoside diphosphate phosphorylation (GO:0006165)3.62341298
63glomerular epithelial cell development (GO:0072310)3.60999603
64GTP biosynthetic process (GO:0006183)3.56297529
65cilium organization (GO:0044782)3.55194607
66ether metabolic process (GO:0018904)3.50726319
67lung epithelium development (GO:0060428)3.49944808
68diterpenoid biosynthetic process (GO:0016102)3.49720823
69nonmotile primary cilium assembly (GO:0035058)3.47247948
70chaperone-mediated protein complex assembly (GO:0051131)3.46089851
71cilium assembly (GO:0042384)3.44220767
72smoothened signaling pathway (GO:0007224)3.43696612
73lateral ventricle development (GO:0021670)3.41546396
74gene silencing by RNA (GO:0031047)3.37451424
75microtubule-based movement (GO:0007018)3.36085715
76centriole assembly (GO:0098534)3.35179029
77cilium morphogenesis (GO:0060271)3.34580997
78establishment of planar polarity (GO:0001736)3.33871795
79establishment of tissue polarity (GO:0007164)3.33871795
80multicellular organismal development (GO:0007275)3.32912755
81protein refolding (GO:0042026)3.31751995
82regulation of interleukin-5 production (GO:0032674)3.30837981
83establishment of apical/basal cell polarity (GO:0035089)3.30521912
84regulation of meiosis I (GO:0060631)3.29027180
85chromosome condensation (GO:0030261)3.24403108
86meiotic cell cycle process (GO:1903046)3.23053992
87determination of left/right symmetry (GO:0007368)3.20276273
88UTP biosynthetic process (GO:0006228)3.17540396
89regulation of spindle checkpoint (GO:0090231)3.15796218
90cellular component assembly involved in morphogenesis (GO:0010927)3.12904087
91DNA packaging (GO:0006323)3.11990912
92cytoplasmic microtubule organization (GO:0031122)3.10883045
93pyrimidine-containing compound transmembrane transport (GO:0072531)3.08524766
94determination of bilateral symmetry (GO:0009855)3.03102109
95microtubule polymerization or depolymerization (GO:0031109)3.02518879
96polyol catabolic process (GO:0046174)3.01889155
97centriole replication (GO:0007099)2.98585596
98regulation of interleukin-13 production (GO:0032656)2.97998615
99retinal rod cell development (GO:0046548)2.96357536
100specification of symmetry (GO:0009799)2.94996729
101nucleus organization (GO:0006997)2.90669050
102guanosine-containing compound biosynthetic process (GO:1901070)2.90307750
103single strand break repair (GO:0000012)2.89696853
104retinoic acid metabolic process (GO:0042573)2.88584287
105phosphatidylethanolamine biosynthetic process (GO:0006646)2.87260527
106tolerance induction (GO:0002507)2.87021221
107negative regulation of B cell mediated immunity (GO:0002713)2.84092807
108negative regulation of immunoglobulin mediated immune response (GO:0002890)2.84092807
109ethanol oxidation (GO:0006069)2.83544888
110regulation of collateral sprouting (GO:0048670)2.82645150
111UTP metabolic process (GO:0046051)2.81517282
112terpenoid biosynthetic process (GO:0016114)2.78891518
113synapsis (GO:0007129)2.78185651
114microtubule-based process (GO:0007017)2.76806365
115organelle assembly (GO:0070925)2.75292116
116phosphatidylethanolamine metabolic process (GO:0046337)2.75141322
117exogenous drug catabolic process (GO:0042738)2.74575496
118lactate metabolic process (GO:0006089)2.72156457
119alditol metabolic process (GO:0019400)2.70973730
120left/right axis specification (GO:0070986)2.69738054
121mitotic sister chromatid cohesion (GO:0007064)2.68706573
122negative regulation of organelle assembly (GO:1902116)2.65080244
123retinal cone cell development (GO:0046549)2.63559360
124glycolytic process (GO:0006096)2.63327219
125protein K11-linked deubiquitination (GO:0035871)2.61936863
126sex differentiation (GO:0007548)2.61142803
127amino-acid betaine transport (GO:0015838)2.57075712
128carnitine transport (GO:0015879)2.57075712
129cellular ketone body metabolic process (GO:0046950)2.56486404
130limb development (GO:0060173)2.55080998
131appendage development (GO:0048736)2.55080998
132gene silencing (GO:0016458)2.54427169
133regulation of centriole replication (GO:0046599)2.52338225
134sexual reproduction (GO:0019953)2.51884139
135peptidyl-glutamic acid modification (GO:0018200)2.51184731
136photoreceptor cell maintenance (GO:0045494)2.50582412
137carnitine transmembrane transport (GO:1902603)2.49168445
138cornea development in camera-type eye (GO:0061303)2.46110269
139spinal cord motor neuron differentiation (GO:0021522)2.46076881
140negative regulation of humoral immune response (GO:0002921)2.45501484
141excretion (GO:0007588)2.41900222
142positive regulation of smoothened signaling pathway (GO:0045880)2.41462753
143regulation of cilium assembly (GO:1902017)2.39363826
144CDP-diacylglycerol biosynthetic process (GO:0016024)2.34953804
145brain morphogenesis (GO:0048854)2.34128982
146heart looping (GO:0001947)2.31773994
147retinol metabolic process (GO:0042572)2.30790690
148regulation of germinal center formation (GO:0002634)2.29604315
149fusion of sperm to egg plasma membrane (GO:0007342)12.4137798
150cilium or flagellum-dependent cell motility (GO:0001539)12.0804988
151* sperm motility (GO:0030317)11.9461481
152epithelial cilium movement (GO:0003351)10.4917519
153* axonemal dynein complex assembly (GO:0070286)10.2811420
154multicellular organism reproduction (GO:0032504)10.2156168
155acrosome reaction (GO:0007340)10.1956121
156sperm-egg recognition (GO:0035036)10.1671755

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.59485003
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.39542994
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.02430105
4DROSHA_22980978_ChIP-Seq_HELA_Human2.97223391
5CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.91093162
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.58795649
7PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.50392589
8CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.48873726
9STAT6_21828071_ChIP-Seq_BEAS2B_Human2.36082855
10VDR_22108803_ChIP-Seq_LS180_Human2.34970181
11MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse10.2512749
12GATA1_26923725_Chip-Seq_HPCs_Mouse1.98869186
13FLI1_27457419_Chip-Seq_LIVER_Mouse1.98267998
14ZNF274_21170338_ChIP-Seq_K562_Hela1.95135989
15CTBP1_25329375_ChIP-Seq_LNCAP_Human1.92971678
16PCGF2_27294783_Chip-Seq_ESCs_Mouse1.77944496
17KAP1_22055183_ChIP-Seq_ESCs_Mouse1.77719307
18EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.74427032
19ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.72100013
20EZH2_27294783_Chip-Seq_ESCs_Mouse1.70718642
21FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.69241647
22KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.67797595
23RBPJ_22232070_ChIP-Seq_NCS_Mouse1.66693007
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.64236927
25ELK4_26923725_Chip-Seq_MESODERM_Mouse1.63986768
26STAT1_17558387_ChIP-Seq_HELA_Human1.62515437
27PIAS1_25552417_ChIP-Seq_VCAP_Human1.59488835
28TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.58982472
29TOP2B_26459242_ChIP-Seq_MCF-7_Human1.57463143
30* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.55438827
31FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.51029585
32* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.50586991
33SUZ12_27294783_Chip-Seq_ESCs_Mouse1.50529110
34NR3C1_21868756_ChIP-Seq_MCF10A_Human1.49609887
35FUS_26573619_Chip-Seq_HEK293_Human1.46115389
36SMAD4_21799915_ChIP-Seq_A2780_Human1.43636482
37CBX2_27304074_Chip-Seq_ESCs_Mouse1.43487104
38SOX2_22085726_ChIP-Seq_NPCs_Mouse1.43359640
39GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.42895183
40MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.42515465
41BMI1_23680149_ChIP-Seq_NPCS_Mouse1.39885367
42TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.39804624
43SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37894608
44CBP_20019798_ChIP-Seq_JUKART_Human1.37359430
45IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.37359430
46ARNT_22903824_ChIP-Seq_MCF-7_Human1.36190828
47TAL1_26923725_Chip-Seq_HPCs_Mouse1.36051765
48PCGF2_27294783_Chip-Seq_NPCs_Mouse1.35590885
49CTCF_27219007_Chip-Seq_Bcells_Human1.34953917
50REST_21632747_ChIP-Seq_MESCs_Mouse1.34908075
51NFE2_27457419_Chip-Seq_LIVER_Mouse1.33783227
52GATA3_21867929_ChIP-Seq_CD8_Mouse1.32273604
53* WDR5_24793694_ChIP-Seq_LNCAP_Human1.31477059
54CTBP2_25329375_ChIP-Seq_LNCAP_Human1.31430955
55RNF2_27304074_Chip-Seq_NSC_Mouse1.30094190
56SMAD3_21741376_ChIP-Seq_EPCs_Human1.27620008
57TDRD3_21172665_ChIP-Seq_MCF-7_Human1.27582881
58SUZ12_27294783_Chip-Seq_NPCs_Mouse1.27082051
59CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.26875724
60RUNX1_26923725_Chip-Seq_HPCs_Mouse1.26640253
61PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.25202439
62PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.25045456
63* ETV1_20927104_ChIP-Seq_GIST48_Human1.25016425
64NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.24236962
65SMAD4_21741376_ChIP-Seq_EPCs_Human1.23541912
66ER_23166858_ChIP-Seq_MCF-7_Human1.23001601
67GBX2_23144817_ChIP-Seq_PC3_Human1.22791406
68AHR_22903824_ChIP-Seq_MCF-7_Human1.22706334
69MYC_19829295_ChIP-Seq_ESCs_Human1.22579499
70LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.22468285
71SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.22402157
72GATA3_21867929_ChIP-Seq_TH1_Mouse1.22219542
73FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.22070788
74TP53_18474530_ChIP-ChIP_U2OS_Human1.21453452
75AR_21572438_ChIP-Seq_LNCaP_Human1.21227152
76ERA_21632823_ChIP-Seq_H3396_Human1.20116128
77P300_19829295_ChIP-Seq_ESCs_Human1.19273906
78JARID2_20075857_ChIP-Seq_MESCs_Mouse1.18496614
79KDM2B_26808549_Chip-Seq_REH_Human1.18324630
80TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18203379
81POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.18203379
82EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.17343332
83FLI1_21867929_ChIP-Seq_TH2_Mouse1.17210436
84* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.17067122
85SMC4_20622854_ChIP-Seq_HELA_Human1.16761671
86ERG_20517297_ChIP-Seq_VCAP_Human1.16259384
87STAT3_23295773_ChIP-Seq_U87_Human1.16190593
88ELF1_20517297_ChIP-Seq_JURKAT_Human1.16109312
89* AR_25329375_ChIP-Seq_VCAP_Human1.14656722
90TAF15_26573619_Chip-Seq_HEK293_Human1.14577624
91MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.13339515
92* SMRT_27268052_Chip-Seq_Bcells_Human1.13069346
93* PHF8_20622853_ChIP-Seq_HELA_Human1.11870196
94* P53_21459846_ChIP-Seq_SAOS-2_Human1.11414180
95RUNX2_22187159_ChIP-Seq_PCA_Human1.10674054
96TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.10030117
97* HNFA_21074721_ChIP-Seq_CACO-2_Human1.09917219
98RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.09718278
99* RBPJ_21746931_ChIP-Seq_IB4_Human1.09303842
100CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09190681
101* PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.09078918
102STAT1_20625510_ChIP-Seq_HELA_Human1.09016834
103TCF4_22108803_ChIP-Seq_LS180_Human1.08068041
104ETV2_25802403_ChIP-Seq_MESCs_Mouse1.07689807
105* CBX2_22325352_ChIP-Seq_293T-Rex_Human1.07624470
106PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.07159684
107GF1_26923725_Chip-Seq_HPCs_Mouse1.06699612
108SMAD3_21741376_ChIP-Seq_ESCs_Human1.06484319
109RAD21_21589869_ChIP-Seq_MESCs_Mouse1.06194982
110SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.06077715
111* TBL1_22424771_ChIP-Seq_293T_Human1.05802617
112* CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.05451479
113YY1_22570637_ChIP-Seq_MALME-3M_Human1.05408822
114CRX_20693478_ChIP-Seq_RETINA_Mouse1.04257612
115ZFP57_27257070_Chip-Seq_ESCs_Mouse1.02980247
116TP63_22573176_ChIP-Seq_HFKS_Human1.02865728
117OCT4_20526341_ChIP-Seq_ESCs_Human1.02854114
118GATA3_21878914_ChIP-Seq_MCF-7_Human1.02624671
119NCOR_22424771_ChIP-Seq_293T_Human1.02533557
120TAF2_19829295_ChIP-Seq_ESCs_Human1.02237764
121EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.02220812
122* PHF8_20622854_ChIP-Seq_HELA_Human1.01708226
123SPI1_26923725_Chip-Seq_HPCs_Mouse1.01448669
124TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00894082
125MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.00621427
126SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.99833613
127BCAT_22108803_ChIP-Seq_LS180_Human0.99538373
128TP63_23658742_ChIP-Seq_EP156T_Human0.99405566
129* NFYA_21822215_ChIP-Seq_K562_Human0.98927304
130MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98913244
131* CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98241248
132RNF2_27304074_Chip-Seq_ESCs_Mouse0.97856024
133NANOG_18555785_Chip-Seq_ESCs_Mouse0.97711585
134TCF4_23295773_ChIP-Seq_U87_Human0.97608422
135* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.97520022
136UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.97516023
137KLF5_20875108_ChIP-Seq_MESCs_Mouse0.96878788
138EED_16625203_ChIP-ChIP_MESCs_Mouse0.96644891
139CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.96214716
140FLI1_21867929_ChIP-Seq_CD8_Mouse0.95644575
141GF1B_26923725_Chip-Seq_HPCs_Mouse0.95630987
142CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.92719582
143CTCF_20526341_ChIP-Seq_ESCs_Human0.92695834
144SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92187627
145EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.90574666
146OCT4_21477851_ChIP-Seq_ESCs_Mouse0.90514985
147OCT4_18555785_Chip-Seq_ESCs_Mouse0.90206856
148PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.89757207
149ESET_19884257_ChIP-Seq_ESCs_Mouse0.89334588
150KLF4_18555785_Chip-Seq_ESCs_Mouse0.88701565
151EZH2_27294783_Chip-Seq_NPCs_Mouse0.88240621
152MYC_27129775_Chip-Seq_CORNEA_Mouse0.88239285
153NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.88012887
154RARA_24833708_ChIP-Seq_LIVER_Mouse0.87584668
155P53_22387025_ChIP-Seq_ESCs_Mouse0.86136717
156FOXA1_27270436_Chip-Seq_PROSTATE_Human0.85984548
157FOXA1_25329375_ChIP-Seq_VCAP_Human0.85984548
158SOX2_21211035_ChIP-Seq_LN229_Human0.85974561
159SOX9_26525672_Chip-Seq_HEART_Mouse0.84407220
160* NFYB_21822215_ChIP-Seq_K562_Human0.84214080
161TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.83745430
162STAT3_18555785_ChIP-Seq_MESCs_Mouse0.83436699
163CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.82291868
164CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.82148853
165RXRA_24833708_ChIP-Seq_LIVER_Mouse0.82137901
166NANOG_20526341_ChIP-Seq_ESCs_Human0.82012449
167CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.81967844

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0003698_abnormal_male_reproductive5.69897636
2* MP0001929_abnormal_gametogenesis5.19770780
3MP0008877_abnormal_DNA_methylation4.80364319
4MP0008875_abnormal_xenobiotic_pharmacok3.84340161
5MP0002210_abnormal_sex_determination3.65350124
6MP0002653_abnormal_ependyma_morphology3.56080513
7* MP0002161_abnormal_fertility/fecundity3.18530770
8MP0008789_abnormal_olfactory_epithelium3.10998069
9MP0001145_abnormal_male_reproductive3.04194897
10MP0000566_synostosis2.81266582
11MP0000653_abnormal_sex_gland2.67797478
12MP0005394_taste/olfaction_phenotype2.50696815
13MP0005499_abnormal_olfactory_system2.50696815
14MP0002277_abnormal_respiratory_mucosa2.09147720
15MP0005377_hearing/vestibular/ear_phenot2.09095338
16MP0003878_abnormal_ear_physiology2.09095338
17MP0005410_abnormal_fertilization14.2591517
18MP0002160_abnormal_reproductive_system1.98218241
19MP0002822_catalepsy1.88163865
20MP0005670_abnormal_white_adipose1.86077629
21MP0005623_abnormal_meninges_morphology1.82175302
22MP0009780_abnormal_chondrocyte_physiolo1.76626993
23MP0003136_yellow_coat_color1.75832934
24MP0009379_abnormal_foot_pigmentation1.73571825
25MP0006292_abnormal_olfactory_placode1.66640989
26MP0002734_abnormal_mechanical_nocicepti1.61241850
27MP0002735_abnormal_chemical_nociception1.54368549
28MP0003880_abnormal_central_pattern1.43336681
29MP0000778_abnormal_nervous_system1.36058693
30MP0003879_abnormal_hair_cell1.34597303
31MP0002876_abnormal_thyroid_physiology1.32413714
32MP0002249_abnormal_larynx_morphology1.32126911
33MP0000631_abnormal_neuroendocrine_gland1.31130923
34MP0008995_early_reproductive_senescence1.30762097
35MP0005248_abnormal_Harderian_gland1.27444186
36MP0000049_abnormal_middle_ear1.25685903
37MP0000955_abnormal_spinal_cord1.23581853
38MP0002272_abnormal_nervous_system1.23254867
39MP0008058_abnormal_DNA_repair1.23234470
40MP0002557_abnormal_social/conspecific_i1.22445377
41MP0001486_abnormal_startle_reflex1.21196490
42MP0005083_abnormal_biliary_tract1.18667525
43MP0003011_delayed_dark_adaptation1.18310312
44MP0009745_abnormal_behavioral_response1.18072956
45MP0001984_abnormal_olfaction1.17002877
46MP0001765_abnormal_ion_homeostasis1.14664674
47MP0001970_abnormal_pain_threshold1.13822879
48MP0002572_abnormal_emotion/affect_behav1.13395532
49MP0001968_abnormal_touch/_nociception1.11831890
50MP0003693_abnormal_embryo_hatching1.07076896
51MP0002233_abnormal_nose_morphology1.05561676
52MP0005389_reproductive_system_phenotype1.03783085
53MP0000383_abnormal_hair_follicle1.01899994
54MP0003646_muscle_fatigue1.01071238
55MP0001485_abnormal_pinna_reflex1.00009958
56MP0009046_muscle_twitch0.98925054
57MP0005195_abnormal_posterior_eye0.98743311
58MP0010094_abnormal_chromosome_stability0.97217719
59MP0002882_abnormal_neuron_morphology0.96154329
60MP0004859_abnormal_synaptic_plasticity0.94793310
61MP0004233_abnormal_muscle_weight0.94421904
62MP0010030_abnormal_orbit_morphology0.94161322
63MP0002752_abnormal_somatic_nervous0.92575764
64MP0002067_abnormal_sensory_capabilities0.92432255
65MP0002229_neurodegeneration0.92242897
66MP0001502_abnormal_circadian_rhythm0.91721316
67MP0004885_abnormal_endolymph0.91044139
68MP0005647_abnormal_sex_gland0.89841035
69MP0002733_abnormal_thermal_nociception0.88282990
70MP0003111_abnormal_nucleus_morphology0.88216462
71MP0002063_abnormal_learning/memory/cond0.86604976
72MP0002168_other_aberrant_phenotype0.86503024
73MP0003115_abnormal_respiratory_system0.86262412
74MP0005646_abnormal_pituitary_gland0.84065191
75MP0005408_hypopigmentation0.83209802
76MP0003635_abnormal_synaptic_transmissio0.82684621
77MP0001905_abnormal_dopamine_level0.82496700
78MP0005423_abnormal_somatic_nervous0.80778918
79MP0009053_abnormal_anal_canal0.79546710
80MP0003786_premature_aging0.78226770
81MP0001661_extended_life_span0.77364955
82MP0005395_other_phenotype0.75969455
83MP0003938_abnormal_ear_development0.75437980
84MP0000013_abnormal_adipose_tissue0.74985178
85MP0008007_abnormal_cellular_replicative0.72588755
86MP0001188_hyperpigmentation0.71366135
87MP0008057_abnormal_DNA_replication0.71294728
88MP0001293_anophthalmia0.70937832
89MP0002928_abnormal_bile_duct0.70631247
90MP0003890_abnormal_embryonic-extraembry0.69635475
91MP0003123_paternal_imprinting0.69396721
92MP0001346_abnormal_lacrimal_gland0.68803993
93MP0002064_seizures0.68581699
94MP0000358_abnormal_cell_content/0.68181211
95MP0003699_abnormal_female_reproductive0.65957571
96MP0002102_abnormal_ear_morphology0.64423564
97MP0005636_abnormal_mineral_homeostasis0.64167053
98MP0000462_abnormal_digestive_system0.62738213
99MP0003942_abnormal_urinary_system0.62048416
100MP0001727_abnormal_embryo_implantation0.59764148
101MP0006072_abnormal_retinal_apoptosis0.59418405
102MP0000534_abnormal_ureter_morphology0.58292446
103MP0004742_abnormal_vestibular_system0.58033663
104MP0002234_abnormal_pharynx_morphology0.56801701
105MP0002693_abnormal_pancreas_physiology0.55950875
106MP0001944_abnormal_pancreas_morphology0.55368437
107MP0001730_embryonic_growth_arrest0.55194798
108MP0003718_maternal_effect0.51968798
109MP0003861_abnormal_nervous_system0.51887563
110MP0004043_abnormal_pH_regulation0.51355213
111MP0003077_abnormal_cell_cycle0.48613812
112MP0001119_abnormal_female_reproductive0.46189641
113MP0005391_vision/eye_phenotype0.46123780
114MP0005379_endocrine/exocrine_gland_phen0.44919920
115MP0004270_analgesia0.44429539
116* MP0002282_abnormal_trachea_morphology0.43926135
117MP0002084_abnormal_developmental_patter0.43736287
118MP0001529_abnormal_vocalization0.43034027
119MP0005253_abnormal_eye_physiology0.42585773
120MP0003283_abnormal_digestive_organ0.41273918
121MP0001849_ear_inflammation0.39750389
122MP0005257_abnormal_intraocular_pressure0.39377381
123MP0001440_abnormal_grooming_behavior0.39102766
124MP0002152_abnormal_brain_morphology0.38548390
125MP0009672_abnormal_birth_weight0.38373275
126MP0002092_abnormal_eye_morphology0.38125494
127MP0003121_genomic_imprinting0.37532389
128MP0002638_abnormal_pupillary_reflex0.35376874
129MP0002909_abnormal_adrenal_gland0.34621125
130MP0001963_abnormal_hearing_physiology0.34504047
131MP0003122_maternal_imprinting0.34438466
132MP0004264_abnormal_extraembryonic_tissu0.34380963
133MP0000026_abnormal_inner_ear0.34247582
134MP0005380_embryogenesis_phenotype0.33612422
135MP0001672_abnormal_embryogenesis/_devel0.33612422
136MP0009703_decreased_birth_body0.33415229
137MP0001324_abnormal_eye_pigmentation0.33343950
138MP0002269_muscular_atrophy0.33248480
139MP0002085_abnormal_embryonic_tissue0.32942703
140MP0005551_abnormal_eye_electrophysiolog0.32754508
141MP0004145_abnormal_muscle_electrophysio0.32496122
142MP0006276_abnormal_autonomic_nervous0.31879505
143MP0008932_abnormal_embryonic_tissue0.31249133
144MP0004133_heterotaxia0.29792230
145MP0001697_abnormal_embryo_size0.29637762
146MP0002163_abnormal_gland_morphology0.29470707
147MP0002132_abnormal_respiratory_system0.28940919
148MP0003787_abnormal_imprinting0.28901755
149MP0002116_abnormal_craniofacial_bone0.28865943
150MP0004019_abnormal_vitamin_homeostasis0.28746909
151MP0010386_abnormal_urinary_bladder0.27975827
152MP0005666_abnormal_adipose_tissue0.27962312
153MP0003953_abnormal_hormone_level0.27334380
154MP0001764_abnormal_homeostasis0.27273030
155MP0003119_abnormal_digestive_system0.27167234
156MP0000678_abnormal_parathyroid_gland0.27103178

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.56619967
2Abnormal respiratory motile cilium morphology (HP:0005938)9.17596884
3Abnormal respiratory epithelium morphology (HP:0012253)9.17596884
4Rhinitis (HP:0012384)8.25439830
5Abnormal ciliary motility (HP:0012262)7.75539154
6Chronic bronchitis (HP:0004469)7.53587282
7Infertility (HP:0000789)6.44588649
8Nasal polyposis (HP:0100582)5.71649246
9Bronchiectasis (HP:0002110)4.84867057
10Male infertility (HP:0003251)4.66806846
11Abnormality of the nasal mucosa (HP:0000433)4.63536480
12Nephronophthisis (HP:0000090)4.49499220
13Bronchitis (HP:0012387)4.47718574
14Chronic hepatic failure (HP:0100626)3.61079219
15Impulsivity (HP:0100710)3.45062890
16Abnormality of the renal medulla (HP:0100957)3.42388510
17Abnormal spermatogenesis (HP:0008669)3.29823334
18Recurrent otitis media (HP:0000403)3.19104527
19Abnormality of midbrain morphology (HP:0002418)2.98210721
20Molar tooth sign on MRI (HP:0002419)2.98210721
21Tubulointerstitial nephritis (HP:0001970)2.96009680
22Recurrent sinusitis (HP:0011108)2.85054201
23Atelectasis (HP:0100750)2.76852478
24Anencephaly (HP:0002323)2.52520130
25Medial flaring of the eyebrow (HP:0010747)2.51990029
26Tubular atrophy (HP:0000092)2.43987672
27Recurrent bronchitis (HP:0002837)2.43806102
28Gonadotropin excess (HP:0000837)2.30367052
29Tubulointerstitial abnormality (HP:0001969)2.29893138
30Chronic otitis media (HP:0000389)2.29516900
31Sclerocornea (HP:0000647)2.26721832
32Pancreatic fibrosis (HP:0100732)2.21715482
33Hyperactive renin-angiotensin system (HP:0000841)2.19042530
34Postaxial foot polydactyly (HP:0001830)2.15612330
35Male pseudohermaphroditism (HP:0000037)2.14894653
36Azoospermia (HP:0000027)2.13802844
37Facial cleft (HP:0002006)2.04046412
38Hypoplasia of the capital femoral epiphysis (HP:0003090)2.00617689
39Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.1907992
40Absent/shortened dynein arms (HP:0200106)12.2839415
41Dynein arm defect of respiratory motile cilia (HP:0012255)12.2839415
42Abnormality of dentin (HP:0010299)1.99980971
43Bell-shaped thorax (HP:0001591)1.93235086
44Median cleft lip (HP:0000161)1.90852878
45Spastic tetraparesis (HP:0001285)1.88737254
46Fibular hypoplasia (HP:0003038)1.87259706
47Congenital hepatic fibrosis (HP:0002612)1.84575229
48Stage 5 chronic kidney disease (HP:0003774)1.82916753
49Asplenia (HP:0001746)1.81872833
50Aplasia/Hypoplasia of the spleen (HP:0010451)1.80936458
51Short nail (HP:0001799)1.80240282
52Broad distal phalanx of finger (HP:0009836)1.79799039
53Abnormality of the dental root (HP:0006486)1.76423633
54Taurodontia (HP:0000679)1.76423633
55Abnormality of permanent molar morphology (HP:0011071)1.76423633
56Cystic liver disease (HP:0006706)1.74666842
57Microglossia (HP:0000171)1.74603750
58Renal dysplasia (HP:0000110)1.74117214
59Furrowed tongue (HP:0000221)1.73123213
60Supernumerary spleens (HP:0009799)1.72174765
61Tubulointerstitial fibrosis (HP:0005576)1.71333991
62Preaxial hand polydactyly (HP:0001177)1.68715729
63Oculomotor apraxia (HP:0000657)1.67531949
64Abnormality of macular pigmentation (HP:0008002)1.67003062
65Postaxial hand polydactyly (HP:0001162)1.66300547
66Short ribs (HP:0000773)1.66264822
67Abnormality of the dental pulp (HP:0006479)1.64496727
68Decreased circulating renin level (HP:0003351)1.64171026
69Abnormality of the lower motor neuron (HP:0002366)1.63900005
70Abnormality of molar (HP:0011077)1.63540560
71Abnormality of molar morphology (HP:0011070)1.63540560
72Abnormal drinking behavior (HP:0030082)1.62461332
73Polydipsia (HP:0001959)1.62461332
74Aplasia/Hypoplasia of the tongue (HP:0010295)1.62444872
75Absent epiphyses (HP:0010577)1.61585978
76Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.61585978
77Heterotopia (HP:0002282)1.57160044
78True hermaphroditism (HP:0010459)1.56808194
79Hyperkalemia (HP:0002153)1.55234486
80Abnormal rod and cone electroretinograms (HP:0008323)1.55198790
81Gait imbalance (HP:0002141)1.54163526
82Congenital primary aphakia (HP:0007707)1.53847969
83Chronic sinusitis (HP:0011109)1.53454643
84Bony spicule pigmentary retinopathy (HP:0007737)1.51660917
85Bile duct proliferation (HP:0001408)1.50193814
86Abnormal biliary tract physiology (HP:0012439)1.50193814
87Abnormality of the renal cortex (HP:0011035)1.49871614
88Pancreatic cysts (HP:0001737)1.49054638
89Short thorax (HP:0010306)1.47055200
90Polyuria (HP:0000103)1.45847550
91Narrow forehead (HP:0000341)1.44692562
92Renal salt wasting (HP:0000127)1.44407965
93Aplasia/Hypoplasia of the lens (HP:0008063)1.43808745
94Dyschromatopsia (HP:0007641)1.43806810
95Cone-rod dystrophy (HP:0000548)1.41882457
96Occipital encephalocele (HP:0002085)1.41428678
97Amyotrophic lateral sclerosis (HP:0007354)1.40678188
98Abnormality of renal excretion (HP:0011036)1.40356127
99Severe visual impairment (HP:0001141)1.38798085
100Cholecystitis (HP:0001082)1.36694718
101Abnormal gallbladder physiology (HP:0012438)1.36694718
102Choroideremia (HP:0001139)1.36471490
103Hemiparesis (HP:0001269)1.36338231
104Nephropathy (HP:0000112)1.35682059
105Bundle branch block (HP:0011710)1.33719175
106Optic nerve coloboma (HP:0000588)1.33234721
107Retinal dysplasia (HP:0007973)1.33160642
108Decreased central vision (HP:0007663)1.32266161
109Nephrogenic diabetes insipidus (HP:0009806)1.30720626
110Multicystic kidney dysplasia (HP:0000003)1.29607737
111Aganglionic megacolon (HP:0002251)1.29051034
112Absent rod-and cone-mediated responses on ERG (HP:0007688)1.28865324
113Glucose intolerance (HP:0000833)1.28659614
114Hyperaldosteronism (HP:0000859)1.27416519
115Holoprosencephaly (HP:0001360)1.26599706
116Genital tract atresia (HP:0001827)1.26146421
117Lissencephaly (HP:0001339)1.25981890
118Hip dysplasia (HP:0001385)1.25902915
119J-shaped sella turcica (HP:0002680)1.25260211
120Aplasia/Hypoplasia of the fibula (HP:0006492)1.24854250
121Retinitis pigmentosa (HP:0000510)1.24285222
122Prominent nasal bridge (HP:0000426)1.23916260
123Vaginal atresia (HP:0000148)1.22274665
124Absent frontal sinuses (HP:0002688)1.22071206
125Degeneration of anterior horn cells (HP:0002398)1.19903205
126Abnormality of the anterior horn cell (HP:0006802)1.19903205
127Truncal obesity (HP:0001956)1.19282349
128Abnormality of renin-angiotensin system (HP:0000847)1.19224760
129Progressive cerebellar ataxia (HP:0002073)1.18901731
130Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.18499797
131Intellectual disability, moderate (HP:0002342)1.16569627
132Type II lissencephaly (HP:0007260)1.16563751
133Fetal akinesia sequence (HP:0001989)1.16256059
134Short femoral neck (HP:0100864)1.16064000
135Abnormal urine output (HP:0012590)1.15099639
136Poor coordination (HP:0002370)1.14820803
137Highly arched eyebrow (HP:0002553)1.13513885
138Anophthalmia (HP:0000528)1.10556034
139Absent speech (HP:0001344)1.10200307

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK37.96806092
2PDK47.96806092
3PRKD35.31959783
4TESK15.25072611
5PDK25.15967583
6ICK3.43166195
7PNCK2.86764245
8MAPK152.65214029
9MST42.62312133
10WNK42.39036069
11BCR2.19578998
12MAP3K41.94570545
13PTK2B1.92420443
14MAP4K21.84675010
15STK391.81381674
16NEK21.70359903
17DYRK1B1.61310765
18NME11.49740575
19STK381.46911306
20EPHA41.38189127
21MAP2K71.33509297
22CASK1.33062209
23PASK1.16505462
24DYRK31.15506863
25ADRBK21.14653390
26WEE11.13602830
27PLK21.06391192
28TLK11.06177142
29MAPK131.04552639
30BUB11.02895319
31WNK10.99424078
32NTRK30.94523707
33OXSR10.94121204
34GRK10.92351151
35PLK40.90713444
36TNIK0.89464068
37TYRO30.87078310
38MAP3K20.85109141
39STK240.79362597
40WNK30.78184299
41EPHA30.77302795
42STK30.76262168
43TTK0.74880252
44SGK4940.74450058
45SGK2230.74450058
46STK38L0.74382024
47MINK10.71572708
48STK110.70603476
49CDK90.69721729
50PDK10.68462434
51CHEK20.66271324
52CDK190.63843990
53ERBB20.63485219
54FGFR20.63397418
55IRAK10.63242922
56MAP2K40.62464239
57CSNK1G20.60775944
58BRAF0.60327596
59BRSK20.59548691
60CHEK10.56987491
61MAP3K70.56676658
62CAMK1G0.56522075
63SIK20.56491410
64ERBB30.55285965
65CCNB10.53167937
66RPS6KA20.53095530
67PAK10.51387727
68STK160.51286512
69CDC70.50480042
70PRKACA0.50153968
71BMPR1B0.48881600
72DYRK1A0.47402173
73PIM20.46325172
74TSSK60.46321571
75NEK60.46041372
76PLK10.45098732
77PRKCQ0.45070867
78ACVR1B0.44472101
79CAMK2A0.43427394
80PRKCE0.42718820
81EPHA20.42658349
82SRPK10.42269948
83AKT30.42028604
84BRSK10.41486036
85MTOR0.40863135
86SGK10.38371945
87PINK10.38154612
88PRKAA20.37424114
89PRKCG0.37064620
90IRAK20.35970892
91UHMK10.35786678
92PAK20.35490211
93EPHB20.34378967
94TESK20.33313356
95PDPK10.33290837
96CDK50.33240318
97ADRBK10.31980230
98MAP2K60.30912785
99ATM0.30841597
100EEF2K0.30641946
101AURKA0.30519618
102CSK0.30487901
103NTRK20.30349157
104PRKCA0.30280484
105MARK20.30278655
106CSNK1G30.29893164
107PRKAA10.29470914
108MAP3K110.29347202
109PKN10.29295914
110ATR0.28020577
111CAMK2G0.26194916
112CAMK10.26090813
113DYRK20.26060069
114MUSK0.25672754
115LRRK20.24111035
116PRKCH0.23289650
117LATS20.22260870
118PRKCD0.22117150
119LATS10.20730769
120MAPKAPK30.18808572
121LMTK20.18462407
122CDK30.16797161
123MAPKAPK50.16648316
124MARK10.16321780
125ARAF0.15404642
126PLK30.15352179
127FRK0.13680918
128EIF2AK10.12014572
129CDK20.11743269
130CDK10.11677616
131TAOK10.10941869
132CSNK2A10.09589480
133GSK3B0.09286558
134MST1R0.09249660
135PIK3CG0.08663737
136AURKB0.07972702
137CAMKK10.07967416
138INSRR0.07650755
139PHKG20.07544950
140PHKG10.07544950
141PAK30.07461501
142PRKCZ0.07110671
143CDK120.06953653
144CSNK1E0.06802714
145PAK40.05298006
146CSNK2A20.05038987
147RPS6KB10.04895394
148PRKCI0.04285503
149DDR20.03857613
150CDC42BPA0.03232884
151PRKG10.03032236
152PRKDC0.02768819
153RPS6KA10.02495378
154MKNK20.02451154
155MAPK80.02413483
156EPHB10.02370588
157PRKACB0.01370723

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007505.03964622
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.90764747
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.50185250
4Chemical carcinogenesis_Homo sapiens_hsa052043.18234229
5Phenylalanine metabolism_Homo sapiens_hsa003603.13954135
6Basal transcription factors_Homo sapiens_hsa030223.01651755
7Pyruvate metabolism_Homo sapiens_hsa006202.96968611
8Histidine metabolism_Homo sapiens_hsa003402.86961066
9Fatty acid biosynthesis_Homo sapiens_hsa000612.85815235
10Glucagon signaling pathway_Homo sapiens_hsa049222.53919488
11Linoleic acid metabolism_Homo sapiens_hsa005912.52440891
12Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.52222169
13Tyrosine metabolism_Homo sapiens_hsa003502.50799971
14Dorso-ventral axis formation_Homo sapiens_hsa043202.45543558
15alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.44315167
16beta-Alanine metabolism_Homo sapiens_hsa004102.31847591
17Oocyte meiosis_Homo sapiens_hsa041142.28152334
18Phototransduction_Homo sapiens_hsa047442.20702376
19Butanoate metabolism_Homo sapiens_hsa006502.13565122
20Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.09500502
21RNA transport_Homo sapiens_hsa030132.06035167
22Nicotine addiction_Homo sapiens_hsa050332.00857300
23Huntingtons disease_Homo sapiens_hsa050161.99682556
24Caffeine metabolism_Homo sapiens_hsa002321.90688318
25Fanconi anemia pathway_Homo sapiens_hsa034601.88669152
26Olfactory transduction_Homo sapiens_hsa047401.87467891
27Glycerophospholipid metabolism_Homo sapiens_hsa005641.86779420
28Retinol metabolism_Homo sapiens_hsa008301.85893811
29Carbohydrate digestion and absorption_Homo sapiens_hsa049731.77079190
30Selenocompound metabolism_Homo sapiens_hsa004501.74781702
31Amphetamine addiction_Homo sapiens_hsa050311.73006496
32Maturity onset diabetes of the young_Homo sapiens_hsa049501.67823866
33Propanoate metabolism_Homo sapiens_hsa006401.66185576
34mRNA surveillance pathway_Homo sapiens_hsa030151.62770039
35Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.61383898
36Pentose phosphate pathway_Homo sapiens_hsa000301.50961193
37Glycerolipid metabolism_Homo sapiens_hsa005611.50620417
38Purine metabolism_Homo sapiens_hsa002301.48911269
39Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.44984014
40Collecting duct acid secretion_Homo sapiens_hsa049661.43785145
41Fructose and mannose metabolism_Homo sapiens_hsa000511.41391619
42Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.38937850
43Glycosaminoglycan degradation_Homo sapiens_hsa005311.37753635
44Peroxisome_Homo sapiens_hsa041461.33086976
45Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.32440032
46ABC transporters_Homo sapiens_hsa020101.28424618
47Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.25827402
48Proteasome_Homo sapiens_hsa030501.25674160
49Insulin secretion_Homo sapiens_hsa049111.25130223
50Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.22729628
51Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.22635119
52Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.20253514
53Hedgehog signaling pathway_Homo sapiens_hsa043401.19869227
54Ether lipid metabolism_Homo sapiens_hsa005651.19110826
55Salivary secretion_Homo sapiens_hsa049701.19062365
56Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.16047478
57Mineral absorption_Homo sapiens_hsa049781.15140108
58Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.14925939
59Antigen processing and presentation_Homo sapiens_hsa046121.14463900
60Steroid hormone biosynthesis_Homo sapiens_hsa001401.13743074
61Cardiac muscle contraction_Homo sapiens_hsa042601.12669014
62PPAR signaling pathway_Homo sapiens_hsa033201.11588667
63Tight junction_Homo sapiens_hsa045301.03305805
64Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.01288720
65Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.99298356
66Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.97761543
67Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.97707491
68Pyrimidine metabolism_Homo sapiens_hsa002400.97272763
69Protein export_Homo sapiens_hsa030600.97219806
70Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.93133984
71Renin secretion_Homo sapiens_hsa049240.93026819
72Cysteine and methionine metabolism_Homo sapiens_hsa002700.92424588
73Taste transduction_Homo sapiens_hsa047420.92283971
74Cell cycle_Homo sapiens_hsa041100.89725717
75Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.89491580
76Estrogen signaling pathway_Homo sapiens_hsa049150.88735139
77Serotonergic synapse_Homo sapiens_hsa047260.86989225
78Glutamatergic synapse_Homo sapiens_hsa047240.86748871
79Tryptophan metabolism_Homo sapiens_hsa003800.83780885
80Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.82802862
81Parkinsons disease_Homo sapiens_hsa050120.81166792
82Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.80605651
83Arachidonic acid metabolism_Homo sapiens_hsa005900.80041480
84Morphine addiction_Homo sapiens_hsa050320.79954866
85Carbon metabolism_Homo sapiens_hsa012000.79649103
86cAMP signaling pathway_Homo sapiens_hsa040240.79400135
87Primary bile acid biosynthesis_Homo sapiens_hsa001200.73134918
88Fat digestion and absorption_Homo sapiens_hsa049750.72938988
89Synaptic vesicle cycle_Homo sapiens_hsa047210.72317839
90GABAergic synapse_Homo sapiens_hsa047270.69094107
91Thyroid hormone synthesis_Homo sapiens_hsa049180.68978111
92Nitrogen metabolism_Homo sapiens_hsa009100.68706302
93Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.67990601
94RNA degradation_Homo sapiens_hsa030180.67948268
95Vibrio cholerae infection_Homo sapiens_hsa051100.67618756
96Cocaine addiction_Homo sapiens_hsa050300.67288907
97Axon guidance_Homo sapiens_hsa043600.65953909
98Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.65764421
99Alzheimers disease_Homo sapiens_hsa050100.63054409
100Spliceosome_Homo sapiens_hsa030400.62439615
101Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62143047
102Long-term potentiation_Homo sapiens_hsa047200.60593788
103Glutathione metabolism_Homo sapiens_hsa004800.59151220
104Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.58719718
105Dopaminergic synapse_Homo sapiens_hsa047280.55690854
106Notch signaling pathway_Homo sapiens_hsa043300.55468325
107Arginine and proline metabolism_Homo sapiens_hsa003300.55251513
108Sulfur metabolism_Homo sapiens_hsa009200.55234700
109Circadian rhythm_Homo sapiens_hsa047100.54564029
110Hippo signaling pathway_Homo sapiens_hsa043900.53013283
111Fatty acid metabolism_Homo sapiens_hsa012120.52629898
112Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.52194203
113Steroid biosynthesis_Homo sapiens_hsa001000.51308557
114Sphingolipid metabolism_Homo sapiens_hsa006000.48048909
115Fatty acid degradation_Homo sapiens_hsa000710.47714203
116cGMP-PKG signaling pathway_Homo sapiens_hsa040220.47097786
117Endocytosis_Homo sapiens_hsa041440.46631305
118Epstein-Barr virus infection_Homo sapiens_hsa051690.46301907
119Biosynthesis of amino acids_Homo sapiens_hsa012300.44814516
120Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.44095136
121Protein digestion and absorption_Homo sapiens_hsa049740.43951081
122Metabolic pathways_Homo sapiens_hsa011000.43357953
123RNA polymerase_Homo sapiens_hsa030200.42898229
124Sulfur relay system_Homo sapiens_hsa041220.42169569
125Adipocytokine signaling pathway_Homo sapiens_hsa049200.42090135
126Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.41355474
127Renin-angiotensin system_Homo sapiens_hsa046140.40986085
128AMPK signaling pathway_Homo sapiens_hsa041520.40621760
129Calcium signaling pathway_Homo sapiens_hsa040200.39759339
130Inositol phosphate metabolism_Homo sapiens_hsa005620.39156197
131Regulation of autophagy_Homo sapiens_hsa041400.38082010
132Homologous recombination_Homo sapiens_hsa034400.36987792
133Circadian entrainment_Homo sapiens_hsa047130.36865986
134Starch and sucrose metabolism_Homo sapiens_hsa005000.36548805
135Vascular smooth muscle contraction_Homo sapiens_hsa042700.35690834
136Basal cell carcinoma_Homo sapiens_hsa052170.34174133
137N-Glycan biosynthesis_Homo sapiens_hsa005100.34121876
138Legionellosis_Homo sapiens_hsa051340.34119418
139Aldosterone synthesis and secretion_Homo sapiens_hsa049250.33606831
140Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.33544903
141Oxidative phosphorylation_Homo sapiens_hsa001900.33420341
142Type II diabetes mellitus_Homo sapiens_hsa049300.33211127
143Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.31281195
144Pentose and glucuronate interconversions_Homo sapiens_hsa000400.30479702
145Vitamin digestion and absorption_Homo sapiens_hsa049770.29978554
146Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.29482981
147Central carbon metabolism in cancer_Homo sapiens_hsa052300.28939799
148Pancreatic secretion_Homo sapiens_hsa049720.28840357
149p53 signaling pathway_Homo sapiens_hsa041150.28621588
150Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.28518401
151Alcoholism_Homo sapiens_hsa050340.28505100
152Choline metabolism in cancer_Homo sapiens_hsa052310.28256394
153Thyroid hormone signaling pathway_Homo sapiens_hsa049190.28169721
154Wnt signaling pathway_Homo sapiens_hsa043100.28053266
155Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.27445682
156Cholinergic synapse_Homo sapiens_hsa047250.26726209
157Gastric acid secretion_Homo sapiens_hsa049710.26435215
158Phosphatidylinositol signaling system_Homo sapiens_hsa040700.26043556
159Oxytocin signaling pathway_Homo sapiens_hsa049210.25174039

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