TEKT3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene product belongs to the tektin family of proteins. Tektins comprise a family of filament-forming proteins that are coassembled with tubulins to form ciliary and flagellar microtubules. The exact function of this gene is not known. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1motile cilium assembly (GO:0044458)9.72358397
2cilium movement (GO:0003341)9.64281138
3piRNA metabolic process (GO:0034587)9.51498289
4spermatid development (GO:0007286)9.17557195
5reproduction (GO:0000003)9.07348460
6epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.93343967
7male meiosis (GO:0007140)8.49661812
8regulation of cilium movement (GO:0003352)8.39553375
9synaptonemal complex organization (GO:0070193)7.92986152
10synaptonemal complex assembly (GO:0007130)7.69865860
11single fertilization (GO:0007338)7.43746436
12sperm capacitation (GO:0048240)7.09793938
13fertilization (GO:0009566)6.34154370
14ventricular system development (GO:0021591)6.17897739
15spermatogenesis (GO:0007283)6.12874203
16male gamete generation (GO:0048232)6.10671871
17negative regulation of inclusion body assembly (GO:0090084)6.04563296
18DNA methylation involved in gamete generation (GO:0043046)5.99740040
19male meiosis I (GO:0007141)5.65659085
20gamete generation (GO:0007276)5.61135303
21organic cation transport (GO:0015695)5.39322775
22chromosome organization involved in meiosis (GO:0070192)5.35742660
23microtubule depolymerization (GO:0007019)5.34617889
24cellular process involved in reproduction in multicellular organism (GO:0022412)5.28611210
25germ cell development (GO:0007281)5.27294498
26microtubule severing (GO:0051013)5.22427575
27regulation of inclusion body assembly (GO:0090083)4.99527198
28meiotic nuclear division (GO:0007126)4.93371213
29regulation of microtubule-based movement (GO:0060632)4.92660828
30cell recognition (GO:0008037)4.83227176
31calcium ion-dependent exocytosis (GO:0017156)4.82638150
32seminiferous tubule development (GO:0072520)4.76324029
33response to pheromone (GO:0019236)4.70162374
34retinal rod cell development (GO:0046548)4.65562913
35meiosis I (GO:0007127)4.56790434
36multicellular organismal reproductive process (GO:0048609)4.41420743
37protein localization to cilium (GO:0061512)4.41273930
38left/right pattern formation (GO:0060972)4.38685150
39meiotic cell cycle (GO:0051321)4.23764263
40microtubule bundle formation (GO:0001578)4.16765774
41intraciliary transport (GO:0042073)4.09758065
42monoubiquitinated protein deubiquitination (GO:0035520)4.06284335
43axoneme assembly (GO:0035082)4.00728617
44positive regulation of meiosis (GO:0045836)3.97137331
45protein polyglutamylation (GO:0018095)3.94443746
46genitalia morphogenesis (GO:0035112)3.88293385
47spermatid nucleus differentiation (GO:0007289)3.80895006
48cellular ketone body metabolic process (GO:0046950)3.80883919
49positive regulation of meiotic cell cycle (GO:0051446)3.73660976
50chaperone-mediated protein complex assembly (GO:0051131)3.73354818
51glycerol ether metabolic process (GO:0006662)3.68123732
52nucleoside diphosphate phosphorylation (GO:0006165)3.61911552
53GTP biosynthetic process (GO:0006183)3.56967104
54multicellular organismal development (GO:0007275)3.54452010
55gene silencing by RNA (GO:0031047)3.54263296
56microtubule-based movement (GO:0007018)3.52327690
57cilium organization (GO:0044782)3.46253625
58nonmotile primary cilium assembly (GO:0035058)3.45729848
59chromosome condensation (GO:0030261)3.40039305
60ether metabolic process (GO:0018904)3.40006373
61phosphatidylethanolamine biosynthetic process (GO:0006646)3.38236461
62negative regulation of organelle assembly (GO:1902116)3.37785250
63ketone body metabolic process (GO:1902224)3.35237610
64DNA packaging (GO:0006323)3.33362387
65pyrimidine nucleobase catabolic process (GO:0006208)3.33184215
66cilium assembly (GO:0042384)3.29341538
67synapsis (GO:0007129)3.22528811
68UTP biosynthetic process (GO:0006228)3.18571782
69cellular component assembly involved in morphogenesis (GO:0010927)3.18223082
70phosphatidylethanolamine metabolic process (GO:0046337)3.17028732
71behavioral response to nicotine (GO:0035095)3.16142355
72meiotic cell cycle process (GO:1903046)3.15373380
73lactate metabolic process (GO:0006089)3.11318503
74amino-acid betaine transport (GO:0015838)3.10694431
75carnitine transport (GO:0015879)3.10694431
76retinal cone cell development (GO:0046549)3.08838008
77carnitine transmembrane transport (GO:1902603)3.05221215
78regulation of spindle checkpoint (GO:0090231)3.03394828
79regulation of centriole replication (GO:0046599)3.02152349
80regulation of transcription involved in cell fate commitment (GO:0060850)3.00629403
81alditol metabolic process (GO:0019400)2.99353011
82protein K11-linked deubiquitination (GO:0035871)2.98150772
83regulation of protein polyubiquitination (GO:1902914)2.92015263
84establishment of protein localization to Golgi (GO:0072600)2.91693037
85protein refolding (GO:0042026)2.89969339
86UTP metabolic process (GO:0046051)2.88941858
87cellular response to nicotine (GO:0071316)2.88673069
88sequestering of actin monomers (GO:0042989)2.87438283
89protein targeting to Golgi (GO:0000042)2.87038109
90cell projection assembly (GO:0030031)2.87027686
91polyol catabolic process (GO:0046174)2.85685737
92opioid receptor signaling pathway (GO:0038003)2.84676664
93centriole assembly (GO:0098534)2.83266996
94spinal cord motor neuron differentiation (GO:0021522)2.80661654
95centriole replication (GO:0007099)2.79637667
96photoreceptor cell development (GO:0042461)2.79521891
97glycolytic process (GO:0006096)2.75252539
98nucleobase catabolic process (GO:0046113)2.75215134
99regulation of meiosis I (GO:0060631)2.73913684
100photoreceptor cell maintenance (GO:0045494)2.71263768
101nephron tubule morphogenesis (GO:0072078)2.70151321
102nephron epithelium morphogenesis (GO:0072088)2.70151321
103left/right axis specification (GO:0070986)2.69925174
104L-fucose catabolic process (GO:0042355)2.69001153
105fucose catabolic process (GO:0019317)2.69001153
106L-fucose metabolic process (GO:0042354)2.69001153
107peptidyl-glutamic acid modification (GO:0018200)2.68488882
108microtubule polymerization or depolymerization (GO:0031109)2.66861620
109single strand break repair (GO:0000012)2.66230894
110limb bud formation (GO:0060174)2.65803701
111mitotic sister chromatid cohesion (GO:0007064)2.65066905
112nuclear pore complex assembly (GO:0051292)2.63622528
113eye photoreceptor cell development (GO:0042462)2.63011954
114* cilium morphogenesis (GO:0060271)2.62644156
115retrograde transport, vesicle recycling within Golgi (GO:0000301)2.62262115
116nucleus organization (GO:0006997)2.62124698
117negative regulation of transcription regulatory region DNA binding (GO:2000678)2.61919097
118glycerol metabolic process (GO:0006071)2.61515033
119one-carbon compound transport (GO:0019755)2.59522010
120vitamin transmembrane transport (GO:0035461)2.59141309
121regulation of mesenchymal cell apoptotic process (GO:2001053)2.55847738
122smoothened signaling pathway (GO:0007224)2.50481203
123determination of left/right symmetry (GO:0007368)2.48103935
124brain morphogenesis (GO:0048854)2.46391671
125limb development (GO:0060173)2.45445169
126appendage development (GO:0048736)2.45445169
127G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.45157990
128protein localization to Golgi apparatus (GO:0034067)2.44606684
129startle response (GO:0001964)2.43913399
130regulation of mesoderm development (GO:2000380)2.37968177
131establishment of tissue polarity (GO:0007164)2.37345656
132establishment of planar polarity (GO:0001736)2.37345656
133pattern specification involved in kidney development (GO:0061004)2.35212318
134cilium or flagellum-dependent cell motility (GO:0001539)13.9234407
135fusion of sperm to egg plasma membrane (GO:0007342)13.3561214
136* sperm motility (GO:0030317)12.1055187
137axonemal dynein complex assembly (GO:0070286)11.6622476
138acrosome assembly (GO:0001675)11.6383299
139sperm-egg recognition (GO:0035036)11.2211994
140multicellular organism reproduction (GO:0032504)11.0434964
141epithelial cilium movement (GO:0003351)10.6426161
142acrosome reaction (GO:0007340)10.6161536
143cell wall macromolecule metabolic process (GO:0044036)10.6084122
144cell wall macromolecule catabolic process (GO:0016998)10.6084122
145binding of sperm to zona pellucida (GO:0007339)10.2742022
146plasma membrane fusion (GO:0045026)10.1566049
147cell-cell recognition (GO:0009988)10.0424551

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.83161133
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.81300767
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.97771043
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.80096365
5PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.68536455
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.57176953
7CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.45665485
8ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.34204016
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.32993432
10CTBP1_25329375_ChIP-Seq_LNCAP_Human2.16716964
11ZNF274_21170338_ChIP-Seq_K562_Hela2.15258602
12EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.09565389
13CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.08022505
14PCGF2_27294783_Chip-Seq_ESCs_Mouse2.04763410
15FUS_26573619_Chip-Seq_HEK293_Human2.00632724
16MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse10.6066829
17AR_21572438_ChIP-Seq_LNCaP_Human1.98966167
18GATA1_26923725_Chip-Seq_HPCs_Mouse1.96664095
19GBX2_23144817_ChIP-Seq_PC3_Human1.94554601
20BMI1_23680149_ChIP-Seq_NPCS_Mouse1.89154888
21STAT6_21828071_ChIP-Seq_BEAS2B_Human1.82189956
22P300_19829295_ChIP-Seq_ESCs_Human1.81987311
23VDR_22108803_ChIP-Seq_LS180_Human1.81975770
24TAF15_26573619_Chip-Seq_HEK293_Human1.79936343
25ELK4_26923725_Chip-Seq_MESODERM_Mouse1.76507769
26DROSHA_22980978_ChIP-Seq_HELA_Human1.76254461
27KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.72606564
28* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.68073948
29TOP2B_26459242_ChIP-Seq_MCF-7_Human1.67404360
30RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.63137218
31PCGF2_27294783_Chip-Seq_NPCs_Mouse1.62993153
32WDR5_24793694_ChIP-Seq_LNCAP_Human1.61710416
33STAT1_17558387_ChIP-Seq_HELA_Human1.61594044
34IGF1R_20145208_ChIP-Seq_DFB_Human1.61138885
35SMAD4_21799915_ChIP-Seq_A2780_Human1.58510184
36* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.54452908
37ER_23166858_ChIP-Seq_MCF-7_Human1.53980345
38KAP1_22055183_ChIP-Seq_ESCs_Mouse1.53299670
39EZH2_27294783_Chip-Seq_ESCs_Mouse1.52895853
40UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.51957256
41CBX2_27304074_Chip-Seq_ESCs_Mouse1.51421422
42SUZ12_27294783_Chip-Seq_ESCs_Mouse1.50638232
43* GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.49471905
44NFE2_27457419_Chip-Seq_LIVER_Mouse1.47014683
45TAL1_26923725_Chip-Seq_HPCs_Mouse1.46546131
46IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.44732566
47CBP_20019798_ChIP-Seq_JUKART_Human1.44732566
48PIAS1_25552417_ChIP-Seq_VCAP_Human1.44383569
49SOX2_22085726_ChIP-Seq_NPCs_Mouse1.44142844
50POU3F2_20337985_ChIP-ChIP_501MEL_Human1.43962253
51GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43214247
52* FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.42934061
53* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.42742287
54* SMAD3_21741376_ChIP-Seq_EPCs_Human1.41535014
55* STAT3_23295773_ChIP-Seq_U87_Human1.40918823
56GATA3_21867929_ChIP-Seq_CD8_Mouse1.39363948
57EED_16625203_ChIP-ChIP_MESCs_Mouse1.39143699
58SUZ12_27294783_Chip-Seq_NPCs_Mouse1.38975494
59AR_25329375_ChIP-Seq_VCAP_Human1.38963440
60KDM2B_26808549_Chip-Seq_REH_Human1.37206086
61MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.36809785
62TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.35899171
63* SMAD4_21741376_ChIP-Seq_EPCs_Human1.32933315
64RUNX2_22187159_ChIP-Seq_PCA_Human1.32872370
65ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.31858449
66SALL1_21062744_ChIP-ChIP_HESCs_Human1.31413493
67BCAT_22108803_ChIP-Seq_LS180_Human1.31128281
68* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.28934003
69TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.28756723
70EZH2_27304074_Chip-Seq_ESCs_Mouse1.27156321
71NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.24697193
72* LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.23703394
73* FLI1_21867929_ChIP-Seq_TH2_Mouse1.23488085
74RNF2_27304074_Chip-Seq_NSC_Mouse1.22583184
75NANOG_19829295_ChIP-Seq_ESCs_Human1.22407679
76SOX2_19829295_ChIP-Seq_ESCs_Human1.22407679
77SMAD3_21741376_ChIP-Seq_ESCs_Human1.22101219
78* TCF4_23295773_ChIP-Seq_U87_Human1.22092441
79* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.21472566
80REST_21632747_ChIP-Seq_MESCs_Mouse1.20827184
81TDRD3_21172665_ChIP-Seq_MCF-7_Human1.20800465
82NANOG_20526341_ChIP-Seq_ESCs_Human1.19146246
83SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.19025547
84CRX_20693478_ChIP-Seq_RETINA_Mouse1.18518287
85JARID2_20064375_ChIP-Seq_MESCs_Mouse1.18417914
86GATA3_21867929_ChIP-Seq_TH1_Mouse1.18218157
87SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.17921089
88JARID2_20075857_ChIP-Seq_MESCs_Mouse1.17701149
89ERA_21632823_ChIP-Seq_H3396_Human1.17692475
90SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.17296051
91* PRDM14_20953172_ChIP-Seq_ESCs_Human1.17136134
92EWS_26573619_Chip-Seq_HEK293_Human1.17010726
93ETV2_25802403_ChIP-Seq_MESCs_Mouse1.16851376
94ETV1_20927104_ChIP-Seq_GIST48_Human1.16407204
95AUTS2_25519132_ChIP-Seq_293T-REX_Human1.15545165
96RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.14928062
97* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.14900048
98POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.14406759
99TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14406759
100* P53_21459846_ChIP-Seq_SAOS-2_Human1.14220688
101NANOG_18555785_Chip-Seq_ESCs_Mouse1.13847292
102TAF2_19829295_ChIP-Seq_ESCs_Human1.13441491
103NCOR_22424771_ChIP-Seq_293T_Human1.13409744
104CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.13246551
105SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.13070263
106GF1_26923725_Chip-Seq_HPCs_Mouse1.13059226
107MYC_19829295_ChIP-Seq_ESCs_Human1.12566610
108MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.12063419
109KLF5_20875108_ChIP-Seq_MESCs_Mouse1.11076051
110SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.10889827
111TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10694546
112AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.10627178
113HOXB7_26014856_ChIP-Seq_BT474_Human1.10026397
114OCT4_18555785_Chip-Seq_ESCs_Mouse1.09881722
115CTBP2_25329375_ChIP-Seq_LNCAP_Human1.09178734
116RAD21_21589869_ChIP-Seq_MESCs_Mouse1.08605360
117ZFP57_27257070_Chip-Seq_ESCs_Mouse1.08413764
118MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.08039058
119EZH2_27294783_Chip-Seq_NPCs_Mouse1.07751113
120EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.07543568
121MTF2_20144788_ChIP-Seq_MESCs_Mouse1.07201802
122RBPJ_21746931_ChIP-Seq_IB4_Human1.07012846
123TCF4_22108803_ChIP-Seq_LS180_Human1.06449205
124GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05986167
125OCT4_20526341_ChIP-Seq_ESCs_Human1.05891115
126TP53_18474530_ChIP-ChIP_U2OS_Human1.05612922
127P53_22387025_ChIP-Seq_ESCs_Mouse1.05577411
128FOXA1_25329375_ChIP-Seq_VCAP_Human1.04600436
129RUNX1_26923725_Chip-Seq_HPCs_Mouse1.04355924
130* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.03920530
131TBL1_22424771_ChIP-Seq_293T_Human1.03548453
132PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.02817917
133RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.02488258
134REST_18959480_ChIP-ChIP_MESCs_Mouse1.02372650
135EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.02253807
136* FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02233062
137ERG_20517297_ChIP-Seq_VCAP_Human1.02223421
138PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.01768846
139CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.01456553
140SMAD4_21741376_ChIP-Seq_HESCs_Human1.01307978
141HNFA_21074721_ChIP-Seq_CACO-2_Human1.00523511
142ARNT_22903824_ChIP-Seq_MCF-7_Human0.99823517
143SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.99799381
144P300_18555785_Chip-Seq_ESCs_Mouse0.99569635
145GATA3_21878914_ChIP-Seq_MCF-7_Human0.99126026
146FOXH1_21741376_ChIP-Seq_EPCs_Human0.99059833
147PHF8_20622853_ChIP-Seq_HELA_Human0.98926579
148* OCT4_21477851_ChIP-Seq_ESCs_Mouse0.97967035
149PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.97905842
150KLF4_18555785_Chip-Seq_ESCs_Mouse0.97670914
151SPI1_26923725_Chip-Seq_HPCs_Mouse0.97622870
152ESRRB_18555785_Chip-Seq_ESCs_Mouse0.97022548
153CMYC_18555785_Chip-Seq_ESCs_Mouse0.96617481
154ESET_19884257_ChIP-Seq_ESCs_Mouse0.95900403
155EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.95241842
156EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.94061057
157YY1_22570637_ChIP-Seq_MALME-3M_Human0.93883072
158STAT3_18555785_Chip-Seq_ESCs_Mouse0.92175571
159CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90623305
160SUZ12_18555785_Chip-Seq_ESCs_Mouse0.90011877
161MYC_27129775_Chip-Seq_CORNEA_Mouse0.89287180
162RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.88747081
163SOX9_26525672_Chip-Seq_HEART_Mouse0.87221327
164LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.87073252
165PU1_27457419_Chip-Seq_LIVER_Mouse0.86654178
166RBPJ_22232070_ChIP-Seq_NCS_Mouse0.86076585
167RXRA_24833708_ChIP-Seq_LIVER_Mouse0.85284130
168* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.85005205
169GF1B_26923725_Chip-Seq_HPCs_Mouse0.84029336
170FLI1_21867929_ChIP-Seq_CD8_Mouse0.83738453
171RARA_24833708_ChIP-Seq_LIVER_Mouse0.82736974
172E2F1_18555785_Chip-Seq_ESCs_Mouse0.82618070
173NFYB_21822215_ChIP-Seq_K562_Human0.82606432
174FOXA1_27270436_Chip-Seq_PROSTATE_Human0.82262305

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0003698_abnormal_male_reproductive6.00046322
2* MP0001929_abnormal_gametogenesis5.48606730
3MP0008877_abnormal_DNA_methylation4.91999840
4MP0002210_abnormal_sex_determination3.77463902
5MP0002653_abnormal_ependyma_morphology3.35552840
6* MP0002161_abnormal_fertility/fecundity3.23454535
7MP0001145_abnormal_male_reproductive3.17077122
8MP0009379_abnormal_foot_pigmentation2.91864154
9MP0000653_abnormal_sex_gland2.77507551
10MP0002735_abnormal_chemical_nociception2.60277550
11MP0005623_abnormal_meninges_morphology2.48440785
12MP0008875_abnormal_xenobiotic_pharmacok2.42970623
13MP0001968_abnormal_touch/_nociception2.39204830
14MP0002160_abnormal_reproductive_system2.27999343
15MP0006292_abnormal_olfactory_placode2.20895685
16MP0004885_abnormal_endolymph2.16725639
17MP0005670_abnormal_white_adipose2.09493696
18MP0003787_abnormal_imprinting2.01927065
19MP0005410_abnormal_fertilization15.5763065
20MP0008789_abnormal_olfactory_epithelium1.90804934
21MP0005645_abnormal_hypothalamus_physiol1.87843198
22MP0002822_catalepsy1.84070155
23MP0005646_abnormal_pituitary_gland1.83989782
24MP0001486_abnormal_startle_reflex1.81874406
25MP0003880_abnormal_central_pattern1.80059608
26MP0001485_abnormal_pinna_reflex1.69592591
27MP0002734_abnormal_mechanical_nocicepti1.67110780
28MP0000566_synostosis1.59389953
29MP0002282_abnormal_trachea_morphology1.56732736
30MP0002272_abnormal_nervous_system1.52869285
31MP0005647_abnormal_sex_gland1.51352052
32MP0005499_abnormal_olfactory_system1.51338721
33MP0005394_taste/olfaction_phenotype1.51338721
34MP0001529_abnormal_vocalization1.47127148
35MP0000049_abnormal_middle_ear1.46644435
36MP0002837_dystrophic_cardiac_calcinosis1.46526056
37MP0009745_abnormal_behavioral_response1.45811958
38MP0001188_hyperpigmentation1.42706359
39MP0008058_abnormal_DNA_repair1.42299680
40MP0004142_abnormal_muscle_tone1.42079471
41MP0002572_abnormal_emotion/affect_behav1.39173847
42MP0000631_abnormal_neuroendocrine_gland1.39083442
43MP0005379_endocrine/exocrine_gland_phen1.38542407
44MP0003646_muscle_fatigue1.38192942
45MP0002557_abnormal_social/conspecific_i1.37683204
46MP0008057_abnormal_DNA_replication1.35777320
47MP0004742_abnormal_vestibular_system1.34151955
48MP0002163_abnormal_gland_morphology1.33924327
49MP0000778_abnormal_nervous_system1.31317267
50MP0002067_abnormal_sensory_capabilities1.29423040
51MP0004859_abnormal_synaptic_plasticity1.28276358
52MP0001970_abnormal_pain_threshold1.28106086
53MP0000026_abnormal_inner_ear1.26815683
54MP0005084_abnormal_gallbladder_morpholo1.25590456
55MP0009046_muscle_twitch1.24515299
56MP0006276_abnormal_autonomic_nervous1.23640571
57MP0009053_abnormal_anal_canal1.23293056
58MP0001963_abnormal_hearing_physiology1.21213252
59MP0003718_maternal_effect1.18666292
60MP0005389_reproductive_system_phenotype1.18160839
61MP0004043_abnormal_pH_regulation1.12800181
62MP0005195_abnormal_posterior_eye1.10917626
63MP0005423_abnormal_somatic_nervous1.10737710
64MP0003122_maternal_imprinting1.08554175
65MP0001440_abnormal_grooming_behavior1.06819801
66MP0002638_abnormal_pupillary_reflex1.03681821
67MP0008872_abnormal_physiological_respon1.03340303
68MP0001765_abnormal_ion_homeostasis1.02629084
69MP0003011_delayed_dark_adaptation1.01741372
70MP0004233_abnormal_muscle_weight1.00580186
71MP0001984_abnormal_olfaction1.00188434
72MP0008995_early_reproductive_senescence1.00134714
73MP0002938_white_spotting1.00056150
74MP0002752_abnormal_somatic_nervous0.99436073
75MP0001905_abnormal_dopamine_level0.98705740
76MP0003121_genomic_imprinting0.97290890
77MP0003283_abnormal_digestive_organ0.97205183
78MP0005386_behavior/neurological_phenoty0.97099936
79MP0004924_abnormal_behavior0.97099936
80MP0000955_abnormal_spinal_cord0.96828402
81MP0003635_abnormal_synaptic_transmissio0.96758502
82MP0002733_abnormal_thermal_nociception0.95914294
83MP0003937_abnormal_limbs/digits/tail_de0.92998413
84MP0002063_abnormal_learning/memory/cond0.92781244
85MP0002876_abnormal_thyroid_physiology0.91547975
86MP0002909_abnormal_adrenal_gland0.90941961
87MP0005174_abnormal_tail_pigmentation0.90650329
88MP0010094_abnormal_chromosome_stability0.90155125
89MP0002249_abnormal_larynx_morphology0.89553127
90MP0004270_analgesia0.86205094
91MP0002229_neurodegeneration0.85153881
92MP0002928_abnormal_bile_duct0.83806270
93MP0002882_abnormal_neuron_morphology0.81845664
94MP0002064_seizures0.79926933
95MP0003950_abnormal_plasma_membrane0.74791012
96MP0008007_abnormal_cellular_replicative0.70758727
97MP0003786_premature_aging0.68117304
98MP0003878_abnormal_ear_physiology0.63608577
99MP0005377_hearing/vestibular/ear_phenot0.63608577
100MP0004134_abnormal_chest_morphology0.63164243
101MP0002234_abnormal_pharynx_morphology0.62182505
102MP0000358_abnormal_cell_content/0.60041322
103MP0003115_abnormal_respiratory_system0.58541826
104MP0000569_abnormal_digit_pigmentation0.57160738
105MP0004133_heterotaxia0.54355297
106MP0003699_abnormal_female_reproductive0.53068463
107MP0005636_abnormal_mineral_homeostasis0.49259634
108MP0005397_hematopoietic_system_phenotyp0.48713266
109MP0001545_abnormal_hematopoietic_system0.48713266
110MP0004036_abnormal_muscle_relaxation0.47324453
111MP0005666_abnormal_adipose_tissue0.46055334
112MP0001324_abnormal_eye_pigmentation0.43657408
113MP0001119_abnormal_female_reproductive0.43654275
114MP0005253_abnormal_eye_physiology0.43260327
115MP0005551_abnormal_eye_electrophysiolog0.41828890
116MP0001293_anophthalmia0.41686493
117MP0008004_abnormal_stomach_pH0.39433383
118MP0003329_amyloid_beta_deposits0.36663753
119MP0010307_abnormal_tumor_latency0.35783978
120MP0004019_abnormal_vitamin_homeostasis0.35746123
121MP0005391_vision/eye_phenotype0.35000099
122MP0003111_abnormal_nucleus_morphology0.34908492
123MP0004808_abnormal_hematopoietic_stem0.33817676
124MP0003045_fibrosis0.32170292
125MP0009278_abnormal_bone_marrow0.31866589
126MP0001764_abnormal_homeostasis0.31328820
127MP0009115_abnormal_fat_cell0.30828665
128MP0001727_abnormal_embryo_implantation0.29728803
129MP0003633_abnormal_nervous_system0.29021370
130MP0003942_abnormal_urinary_system0.28713106
131MP0002269_muscular_atrophy0.28502605
132MP0001730_embryonic_growth_arrest0.27464260
133MP0003861_abnormal_nervous_system0.27178049
134MP0002971_abnormal_brown_adipose0.26120653
135MP0000313_abnormal_cell_death0.23769773
136MP0002796_impaired_skin_barrier0.23683202
137MP0004811_abnormal_neuron_physiology0.23651821
138MP0002152_abnormal_brain_morphology0.23481153
139MP0006036_abnormal_mitochondrial_physio0.22102961
140MP0002084_abnormal_developmental_patter0.20825729
141MP0003879_abnormal_hair_cell0.20636085
142MP0003631_nervous_system_phenotype0.19888110
143MP0002092_abnormal_eye_morphology0.19753620
144MP0001851_eye_inflammation0.19547643
145MP0002102_abnormal_ear_morphology0.18263468
146MP0003936_abnormal_reproductive_system0.17967768
147MP0002132_abnormal_respiratory_system0.17944559
148MP0003943_abnormal_hepatobiliary_system0.17536417
149MP0001986_abnormal_taste_sensitivity0.16843604
150MP0003948_abnormal_gas_homeostasis0.16617398
151MP0006072_abnormal_retinal_apoptosis0.16161869
152MP0002108_abnormal_muscle_morphology0.15990622
153MP0002139_abnormal_hepatobiliary_system0.15713499
154MP0002736_abnormal_nociception_after0.15590055
155MP0001919_abnormal_reproductive_system0.15273567
156MP0002169_no_abnormal_phenotype0.14734480
157MP0002873_normal_phenotype0.14493692
158MP0003136_yellow_coat_color0.14381157
159MP0000534_abnormal_ureter_morphology0.14376416
160MP0002405_respiratory_system_inflammati0.14165519
161MP0002133_abnormal_respiratory_system0.13641135
162MP0005388_respiratory_system_phenotype0.13641135
163MP0002109_abnormal_limb_morphology0.12914267
164MP0005275_abnormal_skin_tensile0.12404433
165MP0001661_extended_life_span0.12166489
166MP0009250_abnormal_appendicular_skeleto0.11889897
167MP0000001_mammalian_phenotype0.11666652
168MP0000432_abnormal_head_morphology0.11534044

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium morphology (HP:0005938)9.29084645
2Abnormal respiratory epithelium morphology (HP:0012253)9.29084645
3Abnormal ciliary motility (HP:0012262)8.50567527
4Rhinitis (HP:0012384)8.33803684
5Chronic bronchitis (HP:0004469)7.27441980
6Infertility (HP:0000789)6.48815075
7Nasal polyposis (HP:0100582)6.44330447
8Abnormality of the nasal mucosa (HP:0000433)5.28985159
9Bronchiectasis (HP:0002110)4.85270269
10Bronchitis (HP:0012387)4.51590797
11Male infertility (HP:0003251)4.32735048
12Nephronophthisis (HP:0000090)4.28496454
13Chronic hepatic failure (HP:0100626)4.21183739
14Recurrent sinusitis (HP:0011108)3.52235702
15Recurrent otitis media (HP:0000403)3.29382170
16Abnormality of the renal medulla (HP:0100957)3.25614626
17Tubulointerstitial nephritis (HP:0001970)3.07723096
18Abnormal spermatogenesis (HP:0008669)2.91350896
19Abnormality of the lower motor neuron (HP:0002366)2.69468301
20Recurrent bronchitis (HP:0002837)2.67690007
21Medial flaring of the eyebrow (HP:0010747)2.66944638
22Abnormal rod and cone electroretinograms (HP:0008323)2.66240280
23Type II lissencephaly (HP:0007260)2.63764481
24Abnormality of midbrain morphology (HP:0002418)2.59621572
25Molar tooth sign on MRI (HP:0002419)2.59621572
26Gonadotropin excess (HP:0000837)2.59203949
27Decreased circulating renin level (HP:0003351)2.46973034
28Tubulointerstitial abnormality (HP:0001969)2.43015542
29Tubular atrophy (HP:0000092)2.41990721
30Concave nail (HP:0001598)2.41795994
31Hyperactive renin-angiotensin system (HP:0000841)2.39388056
32Absent rod-and cone-mediated responses on ERG (HP:0007688)2.30146112
33Fibular hypoplasia (HP:0003038)2.26647940
34Bony spicule pigmentary retinopathy (HP:0007737)2.25164201
35Postaxial foot polydactyly (HP:0001830)2.23878829
36Severe visual impairment (HP:0001141)2.23315191
37Sclerocornea (HP:0000647)2.21207450
38Anencephaly (HP:0002323)2.18018195
39Azoospermia (HP:0000027)2.15173754
40Impulsivity (HP:0100710)2.14896461
41Hyperkalemia (HP:0002153)2.12261853
42Amyotrophic lateral sclerosis (HP:0007354)2.11140128
43Congenital hepatic fibrosis (HP:0002612)2.01365361
44Abnormal biliary tract physiology (HP:0012439)2.00081861
45Bile duct proliferation (HP:0001408)2.00081861
46Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.6353617
47Absent/shortened dynein arms (HP:0200106)12.6429850
48Dynein arm defect of respiratory motile cilia (HP:0012255)12.6429850
49Abnormal respiratory motile cilium physiology (HP:0012261)10.0869928
50Abnormality of dentin (HP:0010299)1.99104461
51Limb dystonia (HP:0002451)1.97472731
52Stage 5 chronic kidney disease (HP:0003774)1.95135251
53Abolished electroretinogram (ERG) (HP:0000550)1.94813562
54Abnormality of the dental root (HP:0006486)1.93021828
55Taurodontia (HP:0000679)1.93021828
56Abnormality of permanent molar morphology (HP:0011071)1.93021828
57Attenuation of retinal blood vessels (HP:0007843)1.89504573
58Chronic sinusitis (HP:0011109)1.88860362
59Retinal dysplasia (HP:0007973)1.86234153
60Increased corneal curvature (HP:0100692)1.85315796
61Keratoconus (HP:0000563)1.85315796
62Pancreatic fibrosis (HP:0100732)1.84668804
63Supernumerary spleens (HP:0009799)1.84464899
64Abnormality of molar (HP:0011077)1.81197910
65Abnormality of molar morphology (HP:0011070)1.81197910
66Tubulointerstitial fibrosis (HP:0005576)1.80046559
67Hypoplasia of the capital femoral epiphysis (HP:0003090)1.77693642
68Progressive cerebellar ataxia (HP:0002073)1.77403608
69Polyuria (HP:0000103)1.75512310
70Cystic liver disease (HP:0006706)1.75213451
71Abnormality of the dental pulp (HP:0006479)1.75124851
72Oculomotor apraxia (HP:0000657)1.74929913
73Chorioretinal atrophy (HP:0000533)1.74138431
74Abnormality of renin-angiotensin system (HP:0000847)1.72274518
75Absent frontal sinuses (HP:0002688)1.69930160
76Short ribs (HP:0000773)1.68895763
77Hyperaldosteronism (HP:0000859)1.68756111
78Facial cleft (HP:0002006)1.67802341
79True hermaphroditism (HP:0010459)1.67655254
80Polyphagia (HP:0002591)1.67470215
81Renal salt wasting (HP:0000127)1.67289377
82J-shaped sella turcica (HP:0002680)1.67173070
83Pendular nystagmus (HP:0012043)1.66221922
84Abnormality of the renal cortex (HP:0011035)1.66191969
85Abnormal drinking behavior (HP:0030082)1.65780635
86Polydipsia (HP:0001959)1.65780635
87Aplasia/Hypoplasia of the tongue (HP:0010295)1.65470527
88Abnormality of macular pigmentation (HP:0008002)1.63825851
89Spastic tetraparesis (HP:0001285)1.62799925
90Congenital primary aphakia (HP:0007707)1.62658894
91Lissencephaly (HP:0001339)1.62643004
92Microglossia (HP:0000171)1.62492035
93Anophthalmia (HP:0000528)1.62483402
94Gait imbalance (HP:0002141)1.61863195
95Impaired proprioception (HP:0010831)1.61635618
96Aplasia/Hypoplasia of the spleen (HP:0010451)1.61230058
97Febrile seizures (HP:0002373)1.60123837
98Asplenia (HP:0001746)1.58757679
99Postaxial hand polydactyly (HP:0001162)1.58595443
100Narrow forehead (HP:0000341)1.57268958
101Genetic anticipation (HP:0003743)1.57123659
102Hypokalemic alkalosis (HP:0001949)1.56248411
103Renal dysplasia (HP:0000110)1.55681816
104Cholecystitis (HP:0001082)1.55104578
105Abnormal gallbladder physiology (HP:0012438)1.55104578
106Preaxial hand polydactyly (HP:0001177)1.54470147
107Occipital encephalocele (HP:0002085)1.53684793
108Broad distal phalanx of finger (HP:0009836)1.52507320
109Median cleft lip (HP:0000161)1.51255539
110Bell-shaped thorax (HP:0001591)1.46813160
111Upper motor neuron abnormality (HP:0002127)1.46576935
112Abnormality of renal excretion (HP:0011036)1.44743367
113Intellectual disability, moderate (HP:0002342)1.44598858
114Cerebellar dysplasia (HP:0007033)1.44074725
115Optic disc pallor (HP:0000543)1.43912878
116Short nail (HP:0001799)1.42932392
117Optic nerve coloboma (HP:0000588)1.41857889
118Retinitis pigmentosa (HP:0000510)1.41817668
119Multicystic kidney dysplasia (HP:0000003)1.41405092
120Hypokalemia (HP:0002900)1.41236167
121Bilateral microphthalmos (HP:0007633)1.40879522
122Nephrogenic diabetes insipidus (HP:0009806)1.39877681
123Short thorax (HP:0010306)1.39300944
124Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.39086326
125Absent epiphyses (HP:0010577)1.39086326
126Heterotopia (HP:0002282)1.39046425
127Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.38256600
128Aplasia/Hypoplasia of the fibula (HP:0006492)1.37978801
129Aplasia/Hypoplasia of the lens (HP:0008063)1.37630421
130Dyschromatopsia (HP:0007641)1.35448812
131Deformed sella turcica (HP:0002681)1.32892348
132Decreased central vision (HP:0007663)1.30691068
133Nephropathy (HP:0000112)1.28877401
134Short femoral neck (HP:0100864)1.23526576
135Pancreatic cysts (HP:0001737)1.22375829
136Poor coordination (HP:0002370)1.21824147
137Genital tract atresia (HP:0001827)1.20751165
138Vaginal atresia (HP:0000148)1.18279899
13911 pairs of ribs (HP:0000878)1.18049209
140Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.16189113
141Pachygyria (HP:0001302)1.14262206
142Male pseudohermaphroditism (HP:0000037)1.13194895
143Abnormal urine output (HP:0012590)1.12955276
144Abnormality of the anterior horn cell (HP:0006802)1.10078838

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK48.67573184
2PDK38.67573184
3PDK25.62771741
4TESK15.13626947
5PRKD34.24531707
6ICK3.49372624
7TIE13.02739063
8PNCK2.61851939
9INSRR2.60486062
10PTK2B2.54989187
11WNK42.48443540
12CASK2.47978360
13STK392.39128341
14ADRBK22.38400447
15TAOK32.28797042
16MAP4K22.20291097
17MARK12.16774773
18FRK2.15747241
19ACVR1B2.01062112
20ZAK1.99458034
21TLK11.87049907
22DDR21.82604035
23NEK21.75527893
24MAPK131.69014128
25PLK21.57503079
26STK381.52953877
27OXSR11.44501073
28MAPK151.42808318
29DYRK21.40805612
30STK161.34460751
31NTRK31.31526389
32MST41.20805642
33PHKG11.20023607
34PHKG21.20023607
35DYRK1B1.15511463
36MAP3K111.14889249
37MAP3K121.13083948
38NUAK11.11617051
39WNK11.04484202
40TNIK1.03556003
41PDK10.95355220
42SIK20.94510237
43TYRO30.91101392
44GRK70.86328900
45CDK190.85971222
46EEF2K0.85569439
47PASK0.85100568
48STK30.84653568
49MATK0.83444382
50CCNB10.81834529
51TEC0.80506222
52DYRK30.79103613
53EPHA40.78950306
54WEE10.75992780
55CDK80.72265886
56TTK0.71811197
57ADRBK10.70252865
58PINK10.69142724
59MAP2K20.67430746
60MINK10.64597544
61IRAK10.63114707
62CAMK1G0.61863501
63TGFBR10.59818679
64CDC70.57954608
65DYRK1A0.57140278
66PRKCE0.56340923
67CHEK20.54365539
68LMTK20.53317032
69CAMK10.52933339
70TXK0.52340071
71AKT30.52197510
72STK240.50144741
73KIT0.50024811
74EPHB20.49478712
75CHEK10.49078466
76MAP3K70.47084807
77PAK30.46976280
78BCR0.46882707
79MUSK0.45750912
80PKN10.45340410
81RIPK10.44481056
82DAPK20.44277042
83MAP2K40.44002719
84ATR0.43581903
85TESK20.42921881
86PDPK10.42493961
87SGK10.40079997
88MAP2K60.39994504
89MAPKAPK50.39050384
90SGK2230.38964871
91SGK4940.38964871
92STK38L0.38429686
93CSNK1G20.38132513
94BRSK20.36610891
95ATM0.35113043
96PRKCG0.34880275
97NTRK20.34320325
98CDK50.33303404
99PAK10.31523386
100ERBB30.30800690
101ROCK10.30090099
102PRKCI0.29122515
103ERBB20.28920068
104CAMKK10.27883340
105MTOR0.25832337
106BMPR1B0.25355166
107RIPK40.24606701
108PAK20.23475433
109PLK40.22904308
110RPS6KB10.22826924
111PLK10.22431775
112NEK60.22061559
113PRKAA10.20458165
114IRAK20.19434612
115MAP3K40.18573216
116GRK10.17274347
117CDK120.17019464
118MAPKAPK30.15053673
119BRSK10.13791726
120MAP2K70.13161752
121BRAF0.12841508
122MARK20.11653487
123PRKCQ0.07954122
124PRKACG0.07414646
125PRKCZ0.07363234
126CSNK2A10.07033269
127PAK40.06659744
128CDK10.06539266
129RPS6KA10.06193930
130MAPK80.05905303
131PRKG10.05716749
132CDC42BPA0.05659533
133CSNK1D0.05280296
134GSK3B0.04894085
135PRKDC0.04543627
136CDK150.04521843
137CDK30.04361500
138STK110.04281293
139PRKG20.04147248
140MARK30.03791303
141CDK20.03384928
142AURKA0.03013069
143WNK30.02944433
144CSNK2A20.02476072
145CDK180.02197904
146CDK11A0.02051826
147MAP3K100.01964033
148STK100.01163771
149ZAP700.00687889
150PRKCB0.00642431
151CAMK2A0.00509359
152PDGFRB-0.0217214
153PRKACA-0.0211427
154PRKCA-0.0191720
155EGFR-0.0188349
156CDK14-0.0115353
157CSK-0.0081321
158RPS6KA3-0.0045941
159CSF1R-0.0035180
160PRKACB-0.0008952

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.96532298
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.19195219
3Pyruvate metabolism_Homo sapiens_hsa006204.14645016
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.00246884
5Fatty acid biosynthesis_Homo sapiens_hsa000613.58465700
6Propanoate metabolism_Homo sapiens_hsa006403.39099013
7Glucagon signaling pathway_Homo sapiens_hsa049222.83491658
8Basal transcription factors_Homo sapiens_hsa030222.70016832
9alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.69049633
10Linoleic acid metabolism_Homo sapiens_hsa005912.60894495
11Phototransduction_Homo sapiens_hsa047442.48445253
12Nicotine addiction_Homo sapiens_hsa050332.47982378
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.43548672
14Fanconi anemia pathway_Homo sapiens_hsa034602.40199411
15Pentose phosphate pathway_Homo sapiens_hsa000302.30378911
16Selenocompound metabolism_Homo sapiens_hsa004502.29151231
17Dorso-ventral axis formation_Homo sapiens_hsa043202.28309476
18Caffeine metabolism_Homo sapiens_hsa002322.27194791
19Oxidative phosphorylation_Homo sapiens_hsa001902.21760388
20Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.20505655
21Butanoate metabolism_Homo sapiens_hsa006502.12745087
22Glycerolipid metabolism_Homo sapiens_hsa005611.98191584
23Huntingtons disease_Homo sapiens_hsa050161.89883076
24Oocyte meiosis_Homo sapiens_hsa041141.89433567
25Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.79699897
26Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.77482948
27Carbohydrate digestion and absorption_Homo sapiens_hsa049731.75831211
28Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.75246809
29Maturity onset diabetes of the young_Homo sapiens_hsa049501.74510352
30PPAR signaling pathway_Homo sapiens_hsa033201.73912683
31Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.70547729
32Phenylalanine metabolism_Homo sapiens_hsa003601.70131654
33Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.67706035
34Parkinsons disease_Homo sapiens_hsa050121.66182908
35Tyrosine metabolism_Homo sapiens_hsa003501.62450507
36Histidine metabolism_Homo sapiens_hsa003401.59434993
37Glycosaminoglycan degradation_Homo sapiens_hsa005311.59186380
38Amphetamine addiction_Homo sapiens_hsa050311.57077927
39Nitrogen metabolism_Homo sapiens_hsa009101.55126505
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.51872448
41Glycerophospholipid metabolism_Homo sapiens_hsa005641.41982623
42Carbon metabolism_Homo sapiens_hsa012001.40555301
43Morphine addiction_Homo sapiens_hsa050321.38303829
44Fructose and mannose metabolism_Homo sapiens_hsa000511.34771266
45Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.33985927
46Renin secretion_Homo sapiens_hsa049241.31338088
47Steroid hormone biosynthesis_Homo sapiens_hsa001401.29396741
48Cardiac muscle contraction_Homo sapiens_hsa042601.27565538
49Alzheimers disease_Homo sapiens_hsa050101.22764955
50Fat digestion and absorption_Homo sapiens_hsa049751.22589656
51Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.20404036
52Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.20395491
53Ether lipid metabolism_Homo sapiens_hsa005651.19275431
54Tryptophan metabolism_Homo sapiens_hsa003801.19125735
55mRNA surveillance pathway_Homo sapiens_hsa030151.14852062
56Purine metabolism_Homo sapiens_hsa002301.08721863
57Mineral absorption_Homo sapiens_hsa049781.08470339
58RNA transport_Homo sapiens_hsa030131.07206413
59Primary bile acid biosynthesis_Homo sapiens_hsa001201.06657709
60Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.06212449
61Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.04988577
62Fatty acid metabolism_Homo sapiens_hsa012121.03271522
63Antigen processing and presentation_Homo sapiens_hsa046120.98920876
64Fatty acid degradation_Homo sapiens_hsa000710.98399603
65Glutamatergic synapse_Homo sapiens_hsa047240.96407354
66Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.95127381
67Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.94841483
68Biosynthesis of amino acids_Homo sapiens_hsa012300.93801685
69Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.92987359
70Peroxisome_Homo sapiens_hsa041460.92669879
71beta-Alanine metabolism_Homo sapiens_hsa004100.91841371
72Serotonergic synapse_Homo sapiens_hsa047260.91399916
73Cocaine addiction_Homo sapiens_hsa050300.90994289
74Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.88387810
75Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.88264346
76Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.86380090
77Glutathione metabolism_Homo sapiens_hsa004800.84538514
78GABAergic synapse_Homo sapiens_hsa047270.83795134
79Ribosome_Homo sapiens_hsa030100.81511457
80Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.81380768
81Long-term potentiation_Homo sapiens_hsa047200.80487352
82Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.80485890
83Collecting duct acid secretion_Homo sapiens_hsa049660.76837307
84ABC transporters_Homo sapiens_hsa020100.71467014
85Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.70550097
86Chemical carcinogenesis_Homo sapiens_hsa052040.69967598
87Drug metabolism - other enzymes_Homo sapiens_hsa009830.69379367
88Dopaminergic synapse_Homo sapiens_hsa047280.69022734
89Arachidonic acid metabolism_Homo sapiens_hsa005900.68665719
90Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.66283312
91Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.65971817
92Calcium signaling pathway_Homo sapiens_hsa040200.65566329
93cGMP-PKG signaling pathway_Homo sapiens_hsa040220.65555113
94Hedgehog signaling pathway_Homo sapiens_hsa043400.64772071
95Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.64192554
96Estrogen signaling pathway_Homo sapiens_hsa049150.62620333
97Cholinergic synapse_Homo sapiens_hsa047250.60088141
98Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.59835769
99Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.59824926
100Vitamin digestion and absorption_Homo sapiens_hsa049770.58633588
101RNA polymerase_Homo sapiens_hsa030200.57025004
102Adipocytokine signaling pathway_Homo sapiens_hsa049200.55949984
103Type II diabetes mellitus_Homo sapiens_hsa049300.55035901
104Renin-angiotensin system_Homo sapiens_hsa046140.54347646
105Insulin secretion_Homo sapiens_hsa049110.53928340
106Arginine and proline metabolism_Homo sapiens_hsa003300.53777488
107Steroid biosynthesis_Homo sapiens_hsa001000.52485477
108Central carbon metabolism in cancer_Homo sapiens_hsa052300.50544545
109Axon guidance_Homo sapiens_hsa043600.49855600
110Phosphatidylinositol signaling system_Homo sapiens_hsa040700.49684422
111Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.48312993
112Thyroid hormone synthesis_Homo sapiens_hsa049180.45026377
113SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44972720
114Regulation of autophagy_Homo sapiens_hsa041400.43702399
115Inositol phosphate metabolism_Homo sapiens_hsa005620.42462103
116VEGF signaling pathway_Homo sapiens_hsa043700.42439443
117Bile secretion_Homo sapiens_hsa049760.40325066
118Systemic lupus erythematosus_Homo sapiens_hsa053220.40174092
119AMPK signaling pathway_Homo sapiens_hsa041520.40020076
120Metabolic pathways_Homo sapiens_hsa011000.39018105
121Endocytosis_Homo sapiens_hsa041440.38539115
122Circadian rhythm_Homo sapiens_hsa047100.38498819
123Pyrimidine metabolism_Homo sapiens_hsa002400.38094884
124Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.37928348
125Aldosterone synthesis and secretion_Homo sapiens_hsa049250.34338861
126Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.34294022
127Legionellosis_Homo sapiens_hsa051340.32734963
128Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.32286591
129Hippo signaling pathway_Homo sapiens_hsa043900.31893207
130Vascular smooth muscle contraction_Homo sapiens_hsa042700.31378599
131Taste transduction_Homo sapiens_hsa047420.31295059
132Synaptic vesicle cycle_Homo sapiens_hsa047210.30358834
133Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.30028078
134RNA degradation_Homo sapiens_hsa030180.28966582
135Pancreatic secretion_Homo sapiens_hsa049720.28703652
136N-Glycan biosynthesis_Homo sapiens_hsa005100.28654331
137Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.26967843
138Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.25868179
139Protein digestion and absorption_Homo sapiens_hsa049740.24816163
140Homologous recombination_Homo sapiens_hsa034400.24354538
141Salivary secretion_Homo sapiens_hsa049700.24329047
142Wnt signaling pathway_Homo sapiens_hsa043100.23490827
143Circadian entrainment_Homo sapiens_hsa047130.23459933
144Ovarian steroidogenesis_Homo sapiens_hsa049130.23148116
145cAMP signaling pathway_Homo sapiens_hsa040240.22711493
146Retinol metabolism_Homo sapiens_hsa008300.20478687
147Olfactory transduction_Homo sapiens_hsa047400.19962200
148Gastric acid secretion_Homo sapiens_hsa049710.19587440
149Pentose and glucuronate interconversions_Homo sapiens_hsa000400.18711369
150Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.18585608
151B cell receptor signaling pathway_Homo sapiens_hsa046620.16201952
152Thyroid hormone signaling pathway_Homo sapiens_hsa049190.15403444
153Basal cell carcinoma_Homo sapiens_hsa052170.13875586
154Cell cycle_Homo sapiens_hsa041100.13565944
155Sulfur metabolism_Homo sapiens_hsa009200.12045030

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