ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	4.05905860
2	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	4.01861187
3	L-phenylalanine metabolic process (GO:0006558)	4.01861187
4	rRNA modification (GO:0000154)	3.95660489
5	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	3.88346941
6	L-phenylalanine catabolic process (GO:0006559)	3.88346941
7	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	3.50466609
8	rRNA methylation (GO:0031167)	3.46759466
9	GDP-mannose metabolic process (GO:0019673)	3.31727824
10	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.21467097
11	cytidine metabolic process (GO:0046087)	3.17070927
12	cytidine catabolic process (GO:0006216)	3.17070927
13	cytidine deamination (GO:0009972)	3.17070927
14	response to thyroid hormone (GO:0097066)	3.13332893
15	autophagic vacuole fusion (GO:0000046)	3.10578736
16	aromatic amino acid family catabolic process (GO:0009074)	2.98858707
17	respiratory chain complex IV assembly (GO:0008535)	2.97471941
18	cytochrome complex assembly (GO:0017004)	2.90368587
19	pseudouridine synthesis (GO:0001522)	2.86931223
20	regulation of mitochondrial translation (GO:0070129)	2.80241936
21	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	2.77538928
22	blood coagulation, intrinsic pathway (GO:0007597)	2.76157835
23	peptidyl-glutamic acid carboxylation (GO:0017187)	2.75962501
24	protein carboxylation (GO:0018214)	2.75962501
25	positive regulation of cellular amine metabolic process (GO:0033240)	2.70093338
26	cellular response to thyroid hormone stimulus (GO:0097067)	2.66202478
27	piRNA metabolic process (GO:0034587)	2.58805766
28	pyrimidine nucleoside catabolic process (GO:0046135)	2.58559112
29	aromatic amino acid family metabolic process (GO:0009072)	2.58282277
30	negative regulation of DNA-templated transcription, elongation (GO:0032785)	2.57635439
31	iron-sulfur cluster assembly (GO:0016226)	2.54232461
32	metallo-sulfur cluster assembly (GO:0031163)	2.54232461
33	DNA methylation involved in gamete generation (GO:0043046)	2.54105630
34	negative regulation of myeloid cell apoptotic process (GO:0033033)	2.53866116
35	folic acid metabolic process (GO:0046655)	2.52919522
36	preassembly of GPI anchor in ER membrane (GO:0016254)	2.51630771
37	imidazole-containing compound metabolic process (GO:0052803)	2.50249122
38	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.50056339
39	tyrosine metabolic process (GO:0006570)	2.46971486
40	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.46527169
41	GPI anchor biosynthetic process (GO:0006506)	2.45375908
42	regulation of memory T cell differentiation (GO:0043380)	2.44994200
43	organelle membrane fusion (GO:0090174)	2.43445282
44	negative regulation of bone mineralization (GO:0030502)	2.43019877
45	pyrimidine nucleotide catabolic process (GO:0006244)	2.42596680
46	very-low-density lipoprotein particle assembly (GO:0034379)	2.42416769
47	S-adenosylmethionine metabolic process (GO:0046500)	2.40417798
48	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.39136106
49	C-terminal protein lipidation (GO:0006501)	2.38568818
50	protein complex biogenesis (GO:0070271)	2.37046626
51	methionine biosynthetic process (GO:0009086)	2.35093283
52	mitochondrial respiratory chain complex assembly (GO:0033108)	2.34206786
53	muscle organ morphogenesis (GO:0048644)	2.33630223
54	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	2.33354156
55	NAD biosynthetic process (GO:0009435)	2.32581562
56	positive regulation of defense response to virus by host (GO:0002230)	2.31647100
57	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.30965352
58	Arp2/3 complex-mediated actin nucleation (GO:0034314)	2.30123399
59	proteasome assembly (GO:0043248)	2.29398759
60	positive regulation of B cell differentiation (GO:0045579)	2.29289188
61	folic acid-containing compound metabolic process (GO:0006760)	2.28352052
62	L-methionine salvage (GO:0071267)	2.26783084
63	L-methionine biosynthetic process (GO:0071265)	2.26783084
64	amino acid salvage (GO:0043102)	2.26783084
65	positive regulation of granulocyte differentiation (GO:0030854)	2.26530310
66	negative regulation of fatty acid biosynthetic process (GO:0045717)	2.26522505
67	xenobiotic catabolic process (GO:0042178)	2.25782479
68	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.25755739
69	ncRNA 3-end processing (GO:0043628)	2.24693349
70	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	2.22977204
71	purine nucleoside diphosphate metabolic process (GO:0009135)	2.22318870
72	purine ribonucleoside diphosphate metabolic process (GO:0009179)	2.22318870
73	mannosylation (GO:0097502)	2.22144508
74	regulation of protein activation cascade (GO:2000257)	2.19544404
75	indole-containing compound catabolic process (GO:0042436)	2.19313610
76	indolalkylamine catabolic process (GO:0046218)	2.19313610
77	tryptophan catabolic process (GO:0006569)	2.19313610
78	urate metabolic process (GO:0046415)	2.19267180
79	proline metabolic process (GO:0006560)	2.19196879
80	cellular metabolic compound salvage (GO:0043094)	2.18307660
81	tetrahydrofolate metabolic process (GO:0046653)	2.18048080
82	regulation of translational fidelity (GO:0006450)	2.16071780
83	regulation of complement activation (GO:0030449)	2.15395452
84	oxaloacetate metabolic process (GO:0006107)	2.14064399
85	heme metabolic process (GO:0042168)	2.13961334
86	regulation of cholesterol esterification (GO:0010872)	2.13898625
87	fusion of sperm to egg plasma membrane (GO:0007342)	2.13110436
88	DNA catabolic process, exonucleolytic (GO:0000738)	2.13083077
89	positive regulation of DNA recombination (GO:0045911)	2.12559215
90	short-chain fatty acid metabolic process (GO:0046459)	2.12422297
91	regulation of B cell apoptotic process (GO:0002902)	2.12389135
92	regulation of T-helper 1 cell differentiation (GO:0045625)	2.11892830
93	pyrimidine-containing compound salvage (GO:0008655)	2.10947908
94	pyrimidine nucleoside salvage (GO:0043097)	2.10947908
95	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.10381041
96	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.10381041
97	NADH dehydrogenase complex assembly (GO:0010257)	2.10381041
98	cytolysis (GO:0019835)	2.09830202
99	high-density lipoprotein particle remodeling (GO:0034375)	2.09821712
100	heme biosynthetic process (GO:0006783)	2.09771803

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.11563171
2	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.76732995
3	ZNF263_19887448_ChIP-Seq_K562_Human	2.59067672
4	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.50510042
5	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.40287973
6	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	2.36166535
7	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.35916005
8	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	2.35021253
9	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	2.27587158
10	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	2.23155583
11	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.19071845
12	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.18934047
13	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.11054625
14	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.05433273
15	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.91014023
16	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.90027321
17	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.87835431
18	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.87626161
19	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.80339741
20	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.73926679
21	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.73867418
22	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.72797337
23	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.70066937
24	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.69223638
25	GABP_19822575_ChIP-Seq_HepG2_Human	1.65270158
26	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.64358648
27	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.62973609
28	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.62958928
29	PPARA_22158963_ChIP-Seq_LIVER_Mouse	1.62482188
30	NCOR1_26117541_ChIP-Seq_K562_Human	1.60246359
31	RXR_22158963_ChIP-Seq_LIVER_Mouse	1.60127920
32	DCP1A_22483619_ChIP-Seq_HELA_Human	1.55788737
33	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.54038631
34	FOXP3_21729870_ChIP-Seq_TREG_Human	1.53486373
35	SCL_19346495_ChIP-Seq_HPC-7_Human	1.52907966
36	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.52720942
37	VDR_21846776_ChIP-Seq_THP-1_Human	1.52471369
38	CIITA_25753668_ChIP-Seq_RAJI_Human	1.51017616
39	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	1.49367106
40	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.46533263
41	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.46447208
42	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.45877789
43	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.44998465
44	VDR_23849224_ChIP-Seq_CD4+_Human	1.44402027
45	MEIS1_20887958_ChIP-Seq_HPC-7_Mouse	1.44226944
46	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.43307987
47	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.42047922
48	TFEB_21752829_ChIP-Seq_HELA_Human	1.40818643
49	BCL6_27268052_Chip-Seq_Bcells_Human	1.40637545
50	P68_20966046_ChIP-Seq_HELA_Human	1.40279310
51	KDM5A_27292631_Chip-Seq_BREAST_Human	1.38650464
52	BCOR_27268052_Chip-Seq_Bcells_Human	1.38089432
53	SPI1_23547873_ChIP-Seq_NB4_Human	1.37747233
54	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.35448128
55	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.34089633
56	GATA1_19941826_ChIP-Seq_K562_Human	1.33143433
57	LXR_22292898_ChIP-Seq_THP-1_Human	1.31848422
58	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.29109264
59	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.28272628
60	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	1.28166303
61	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	1.27613021
62	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	1.27231972
63	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.27016353
64	GATA1_22383799_ChIP-Seq_G1ME_Mouse	1.26546779
65	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.26270564
66	E2F1_20622854_ChIP-Seq_HELA_Human	1.25931408
67	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.25367449
68	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.24876844
69	XRN2_22483619_ChIP-Seq_HELA_Human	1.24036637
70	MAF_26560356_Chip-Seq_TH2_Human	1.23370698
71	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.23343073
72	UTX_26944678_Chip-Seq_JUKART_Human	1.22658694
73	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.22107623
74	SPI1_23127762_ChIP-Seq_K562_Human	1.21859363
75	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.21502835
76	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	1.20569760
77	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.20353630
78	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.16675540
79	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.13174157
80	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.11820855
81	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.11379231
82	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.09972005
83	STAT1_20625510_ChIP-Seq_HELA_Human	1.08707623
84	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.08606082
85	RUNX1_22412390_ChIP-Seq_EML_Mouse	1.08523226
86	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.07663596
87	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.07602067
88	P300_27268052_Chip-Seq_Bcells_Human	1.06579607
89	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.05693200
90	E2F7_22180533_ChIP-Seq_HELA_Human	1.05606935
91	MYC_22102868_ChIP-Seq_BL_Human	1.04610554
92	CTCF_27219007_Chip-Seq_ERYTHROID_Human	1.03860119
93	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.03074649
94	GATA2_22383799_ChIP-Seq_G1ME_Mouse	1.03053495
95	PHF8_20622854_ChIP-Seq_HELA_Human	1.02804986
96	MAF_26560356_Chip-Seq_TH1_Human	1.00904572
97	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.00716585
98	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	1.00348786
99	CTCF_26484167_Chip-Seq_Bcells_Mouse	1.00119753
100	CTCF_20526341_ChIP-Seq_ESCs_Human	0.98553649

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003806_abnormal_nucleotide_metabolis	4.82479394
2	MP0005451_abnormal_body_composition	3.67923490
3	MP0005058_abnormal_lysosome_morphology	3.44471149
4	MP0002139_abnormal_hepatobiliary_system	3.19687627
5	MP0005464_abnormal_platelet_physiology	2.87429726
6	MP0000372_irregular_coat_pigmentation	2.43386087
7	MP0008875_abnormal_xenobiotic_pharmacok	2.29071134
8	MP0005360_urolithiasis	2.27121875
9	MP0001661_extended_life_span	2.23789918
10	MP0002148_abnormal_hypersensitivity_rea	2.08771547
11	MP0006036_abnormal_mitochondrial_physio	2.06973434
12	MP0003195_calcinosis	2.01009441
13	MP0009840_abnormal_foam_cell	1.95506214
14	MP0005408_hypopigmentation	1.94543492
15	MP0002132_abnormal_respiratory_system	1.90243242
16	MP0000678_abnormal_parathyroid_gland	1.89278200
17	MP0005365_abnormal_bile_salt	1.88899045
18	MP0005397_hematopoietic_system_phenotyp	1.84295850
19	MP0001545_abnormal_hematopoietic_system	1.84295850
20	MP0003172_abnormal_lysosome_physiology	1.83566692
21	MP0005671_abnormal_response_to	1.79706407
22	MP0009333_abnormal_splenocyte_physiolog	1.74483062
23	MP0001835_abnormal_antigen_presentation	1.69475916
24	MP0005083_abnormal_biliary_tract	1.65456526
25	MP0009785_altered_susceptibility_to	1.64298246
26	MP0005171_absent_coat_pigmentation	1.64059828
27	MP0005332_abnormal_amino_acid	1.60373903
28	MP0003656_abnormal_erythrocyte_physiolo	1.57218323
29	MP0003436_decreased_susceptibility_to	1.55815071
30	MP0005075_abnormal_melanosome_morpholog	1.51107419
31	MP0001853_heart_inflammation	1.48411084
32	MP0005636_abnormal_mineral_homeostasis	1.48365700
33	MP0006082_CNS_inflammation	1.43890378
34	MP0005000_abnormal_immune_tolerance	1.43708745
35	MP0000015_abnormal_ear_pigmentation	1.42974057
36	MP0005410_abnormal_fertilization	1.36689472
37	MP0008058_abnormal_DNA_repair	1.36459799
38	MP0005025_abnormal_response_to	1.36378310
39	MP0004947_skin_inflammation	1.35503283
40	MP0005085_abnormal_gallbladder_physiolo	1.34717960
41	MP0008469_abnormal_protein_level	1.34597013
42	MP0004381_abnormal_hair_follicle	1.34107184
43	MP0003186_abnormal_redox_activity	1.33628629
44	MP0001764_abnormal_homeostasis	1.33592260
45	MP0002877_abnormal_melanocyte_morpholog	1.28797523
46	MP0000681_abnormal_thyroid_gland	1.28040734
47	MP0010329_abnormal_lipoprotein_level	1.26155386
48	MP0002723_abnormal_immune_serum	1.24017453
49	MP0003786_premature_aging	1.21408510
50	MP0006035_abnormal_mitochondrial_morpho	1.19841888
51	MP0004147_increased_porphyrin_level	1.18432993
52	MP0002837_dystrophic_cardiac_calcinosis	1.18163891
53	MP0009697_abnormal_copulation	1.15983999
54	MP0002876_abnormal_thyroid_physiology	1.15174752
55	MP0005319_abnormal_enzyme/_coenzyme	1.14583516
56	MP0000609_abnormal_liver_physiology	1.09927548
57	MP0003045_fibrosis	1.09825643
58	MP0002419_abnormal_innate_immunity	1.08519080
59	MP0000858_altered_metastatic_potential	1.08190599
60	MP0001845_abnormal_inflammatory_respons	1.07748664
61	MP0000689_abnormal_spleen_morphology	1.07267108
62	MP0003950_abnormal_plasma_membrane	1.07125866
63	MP0005646_abnormal_pituitary_gland	1.06731162
64	MP0002396_abnormal_hematopoietic_system	1.06481378
65	MP0009763_increased_sensitivity_to	1.06470085
66	MP0002398_abnormal_bone_marrow	1.05606948
67	MP0009643_abnormal_urine_homeostasis	1.05186418
68	MP0005174_abnormal_tail_pigmentation	1.03989532
69	MP0002420_abnormal_adaptive_immunity	1.03161943
70	MP0001819_abnormal_immune_cell	1.03125703
71	MP0003646_muscle_fatigue	1.02764080
72	MP0002452_abnormal_antigen_presenting	1.02085862
73	MP0002722_abnormal_immune_system	1.01856313
74	MP0001800_abnormal_humoral_immune	1.01806563
75	MP0005387_immune_system_phenotype	1.00945656
76	MP0001790_abnormal_immune_system	1.00945656
77	MP0000371_diluted_coat_color	0.98400624
78	MP0005167_abnormal_blood-brain_barrier	0.94738778
79	MP0002429_abnormal_blood_cell	0.94506356
80	MP0002118_abnormal_lipid_homeostasis	0.92322773
81	MP0003075_altered_response_to	0.91581951
82	MP0003763_abnormal_thymus_physiology	0.91532591
83	MP0000716_abnormal_immune_system	0.89409645
84	MP0000685_abnormal_immune_system	0.88735417
85	MP0008995_early_reproductive_senescence	0.86263488
86	MP0009642_abnormal_blood_homeostasis	0.84622957
87	MP0000598_abnormal_liver_morphology	0.84296477
88	MP0003111_abnormal_nucleus_morphology	0.83332172
89	MP0010155_abnormal_intestine_physiology	0.82927627
90	MP0005165_increased_susceptibility_to	0.82761018
91	MP0003718_maternal_effect	0.81412353
92	MP0005330_cardiomyopathy	0.81245496
93	MP0002019_abnormal_tumor_incidence	0.79579363
94	MP0002405_respiratory_system_inflammati	0.78506547
95	MP0000639_abnormal_adrenal_gland	0.77101767
96	MP0000703_abnormal_thymus_morphology	0.76418522
97	MP0002138_abnormal_hepatobiliary_system	0.75045408
98	MP0008007_abnormal_cellular_replicative	0.75009157
99	MP0009765_abnormal_xenobiotic_induced	0.74972023
100	MP0008004_abnormal_stomach_pH	0.73601578

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Petechiae (HP:0000967)	4.58359990
2	Abnormality of aromatic amino acid family metabolism (HP:0004338)	3.84832305
3	Purpura (HP:0000979)	3.73083909
4	Prolonged bleeding time (HP:0003010)	3.70545208
5	Renal Fanconi syndrome (HP:0001994)	3.24559158
6	Prolonged partial thromboplastin time (HP:0003645)	3.13097257
7	Increased serum ferritin (HP:0003281)	3.11736234
8	Seborrheic dermatitis (HP:0001051)	2.95931445
9	Deep venous thrombosis (HP:0002625)	2.83336139
10	Abnormality of iron homeostasis (HP:0011031)	2.79636812
11	Prolonged neonatal jaundice (HP:0006579)	2.75250556
12	Hyperthyroidism (HP:0000836)	2.72696769
13	Menorrhagia (HP:0000132)	2.72325985
14	Aplastic anemia (HP:0001915)	2.67645440
15	Abnormality of transition element cation homeostasis (HP:0011030)	2.66918850
16	Generalized aminoaciduria (HP:0002909)	2.66876266
17	Hepatocellular necrosis (HP:0001404)	2.59770362
18	Hemorrhage of the eye (HP:0011885)	2.59561845
19	Hepatic necrosis (HP:0002605)	2.59475873
20	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.59118021
21	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.59118021
22	Vacuolated lymphocytes (HP:0001922)	2.55236350
23	Dysostosis multiplex (HP:0000943)	2.54826545
24	Systemic lupus erythematosus (HP:0002725)	2.54421860
25	Reduced antithrombin III activity (HP:0001976)	2.53040502
26	Truncus arteriosus (HP:0001660)	2.52501725
27	Increased intramyocellular lipid droplets (HP:0012240)	2.50713990
28	Elevated erythrocyte sedimentation rate (HP:0003565)	2.49339668
29	Increased muscle lipid content (HP:0009058)	2.49180767
30	Abnormality of glycolipid metabolism (HP:0010969)	2.47035194
31	Abnormality of liposaccharide metabolism (HP:0010968)	2.47035194
32	Abnormality of glycosphingolipid metabolism (HP:0004343)	2.47035194
33	Abnormality of lateral ventricle (HP:0030047)	2.46882056
34	Increased CSF lactate (HP:0002490)	2.45282513
35	Mitochondrial inheritance (HP:0001427)	2.41850912
36	Hypertensive crisis (HP:0100735)	2.40537827
37	Joint hemorrhage (HP:0005261)	2.39522971
38	Epistaxis (HP:0000421)	2.39170821
39	Ragged-red muscle fibers (HP:0003200)	2.37822165
40	Poikilocytosis (HP:0004447)	2.34043403
41	Abnormal mitochondria in muscle tissue (HP:0008316)	2.29771160
42	Lipid accumulation in hepatocytes (HP:0006561)	2.27112526
43	Male infertility (HP:0003251)	2.26917105
44	Abnormal gallbladder physiology (HP:0012438)	2.26360531
45	Cholecystitis (HP:0001082)	2.26360531
46	Increased serum lactate (HP:0002151)	2.25838309
47	Type I transferrin isoform profile (HP:0003642)	2.20726911
48	Increased hepatocellular lipid droplets (HP:0006565)	2.19861966
49	Reticulocytosis (HP:0001923)	2.12267632
50	Abnormal protein glycosylation (HP:0012346)	2.11337712
51	Abnormal glycosylation (HP:0012345)	2.11337712
52	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.11337712
53	Abnormal protein N-linked glycosylation (HP:0012347)	2.11337712
54	Rough bone trabeculation (HP:0100670)	2.11032328
55	J-shaped sella turcica (HP:0002680)	2.10693860
56	Abnormality of polysaccharide metabolism (HP:0011012)	2.10194151
57	Abnormality of glycosaminoglycan metabolism (HP:0004371)	2.10194151
58	Abnormality of mucopolysaccharide metabolism (HP:0011020)	2.10194151
59	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.09989757
60	Cutaneous melanoma (HP:0012056)	2.09879926
61	Acute necrotizing encephalopathy (HP:0006965)	2.08446680
62	Testicular atrophy (HP:0000029)	2.07655687
63	Abnormality of the common coagulation pathway (HP:0010990)	2.06233822
64	Acute encephalopathy (HP:0006846)	2.05203135
65	Abnormality of the heme biosynthetic pathway (HP:0010472)	2.04971088
66	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.99993508
67	Acanthocytosis (HP:0001927)	1.99298584
68	Abnormality of T cell physiology (HP:0011840)	1.98916074
69	Mucopolysacchariduria (HP:0008155)	1.96363588
70	Urinary glycosaminoglycan excretion (HP:0003541)	1.96363588
71	Gingival bleeding (HP:0000225)	1.95288518
72	Orthostatic hypotension (HP:0001278)	1.94697214
73	Pigmentary retinal degeneration (HP:0001146)	1.94448652
74	Abnormal pupillary function (HP:0007686)	1.93851468
75	Pustule (HP:0200039)	1.92526323
76	Obstructive lung disease (HP:0006536)	1.90599123
77	Chronic obstructive pulmonary disease (HP:0006510)	1.90599123
78	Polycythemia (HP:0001901)	1.90456735
79	Abnormality of fatty-acid metabolism (HP:0004359)	1.89020439
80	Abnormal trabecular bone morphology (HP:0100671)	1.87572899
81	Esophageal neoplasm (HP:0100751)	1.87324189
82	Neoplasm of head and neck (HP:0012288)	1.87324189
83	Lactic acidosis (HP:0003128)	1.86642554
84	Complement deficiency (HP:0004431)	1.86203876
85	Autoimmune hemolytic anemia (HP:0001890)	1.85868037
86	Atelectasis (HP:0100750)	1.85635415
87	Impaired platelet aggregation (HP:0003540)	1.83682626
88	Abnormal platelet function (HP:0011869)	1.83682626
89	Poor head control (HP:0002421)	1.82415445
90	Spastic paraparesis (HP:0002313)	1.81651578
91	Hypophosphatemic rickets (HP:0004912)	1.79489109
92	Acute hepatic failure (HP:0006554)	1.78720154
93	Opisthotonus (HP:0002179)	1.75421290
94	Joint swelling (HP:0001386)	1.74062497
95	Glomerulonephritis (HP:0000099)	1.73888065
96	Dysautonomia (HP:0002459)	1.73514578
97	Progressive microcephaly (HP:0000253)	1.73058334
98	Abnormality of macrophages (HP:0004311)	1.72472861
99	Short middle phalanx of the 5th finger (HP:0004220)	1.72009995
100	Premature graying of hair (HP:0002216)	1.71334795

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TAOK3	3.74366971
2	NME2	3.73863400
3	ERN1	3.05470630
4	IRAK3	2.91676077
5	MST4	2.39850498
6	TESK2	2.19135924
7	TLK1	2.18041109
8	MAPKAPK3	2.08619198
9	EIF2AK1	2.05332356
10	PIM2	2.04802765
11	TBK1	2.00793366
12	MAP2K6	1.86103202
13	BMPR2	1.83877611
14	STK16	1.83768320
15	MAP4K1	1.81378828
16	PDK2	1.76387490
17	KDR	1.65625174
18	IKBKB	1.64105183
19	TXK	1.63064600
20	TRIB3	1.59404326
21	MAP2K3	1.54642244
22	TNK2	1.45215637
23	RIPK4	1.40296979
24	CCNB1	1.37888873
25	VRK2	1.36524889
26	MAP3K3	1.26590093
27	ZAK	1.24875335
28	INSRR	1.23031718
29	ZAP70	1.22090600
30	PRKD3	1.20568334
31	TYK2	1.16577472
32	MATK	1.16314819
33	ADRBK2	1.15884363
34	GRK6	1.09020358
35	WNK4	1.07357354
36	GRK7	1.06505320
37	ARAF	1.06286208
38	BMX	1.04398468
39	RAF1	1.04090329
40	TAOK2	1.03505888
41	TRPM7	1.01380169
42	BCKDK	0.99849474
43	TRIM28	0.92333282
44	MUSK	0.91527462
45	SYK	0.90889737
46	EIF2AK3	0.90601139
47	KSR2	0.86597961
48	CDK12	0.86075900
49	MARK3	0.85655002
50	MAP3K2	0.84535088
51	MAP3K1	0.84300164
52	CSF1R	0.83930455
53	ITK	0.83674177
54	MAP3K11	0.80563593
55	MYLK	0.77068970
56	MAPK11	0.74159735
57	SCYL2	0.72586339
58	TEC	0.71317980
59	CLK1	0.71008821
60	BTK	0.70109157
61	MAP3K14	0.67963797
62	DAPK1	0.67868116
63	ILK	0.67690591
64	PRKCI	0.63441614
65	GRK5	0.62666244
66	PTK2B	0.62479370
67	PRKD2	0.59348691
68	PDPK1	0.58744146
69	FGFR4	0.58153004
70	SIK3	0.57974526
71	TGFBR2	0.57833615
72	ABL2	0.57282021
73	ICK	0.56435811
74	CDK7	0.55811677
75	JAK3	0.54317240
76	DAPK3	0.51855046
77	PKN2	0.51780971
78	MST1R	0.51079822
79	ATR	0.50843526
80	NME1	0.50828362
81	PRKD1	0.48934687
82	JAK2	0.48739203
83	SIK1	0.48343220
84	IRAK4	0.47188452
85	PIM1	0.47092388
86	PAK1	0.47043062
87	BLK	0.46189792
88	TESK1	0.45334441
89	MAPKAPK2	0.45324332
90	CSNK1G3	0.44476696
91	LYN	0.44174227
92	IKBKE	0.43695577
93	MAP3K13	0.43678458
94	RPS6KA5	0.42076444
95	MAPK3	0.41672152
96	PDK1	0.41060258
97	NTRK3	0.38838855
98	MAP2K2	0.37016910
99	DDR2	0.35390352
100	JAK1	0.33735061

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Other glycan degradation_Homo sapiens_hsa00511	3.17241907
2	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.73426047
3	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	2.38567623
4	Glycosaminoglycan degradation_Homo sapiens_hsa00531	2.28041199
5	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	2.16972679
6	One carbon pool by folate_Homo sapiens_hsa00670	2.01948508
7	Sulfur relay system_Homo sapiens_hsa04122	1.98676888
8	Complement and coagulation cascades_Homo sapiens_hsa04610	1.91410758
9	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.84838271
10	Proteasome_Homo sapiens_hsa03050	1.80262475
11	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.76245638
12	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.72735514
13	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.63337158
14	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	1.56874621
15	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.55907686
16	Peroxisome_Homo sapiens_hsa04146	1.54199881
17	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.52869822
18	Homologous recombination_Homo sapiens_hsa03440	1.51908007
19	Oxidative phosphorylation_Homo sapiens_hsa00190	1.51828659
20	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.47426575
21	Lysosome_Homo sapiens_hsa04142	1.45265242
22	Primary immunodeficiency_Homo sapiens_hsa05340	1.44911284
23	Tyrosine metabolism_Homo sapiens_hsa00350	1.42359903
24	Chemical carcinogenesis_Homo sapiens_hsa05204	1.39210584
25	Glutathione metabolism_Homo sapiens_hsa00480	1.39071216
26	Pyrimidine metabolism_Homo sapiens_hsa00240	1.39007435
27	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.36635605
28	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.36134052
29	RNA polymerase_Homo sapiens_hsa03020	1.27562197
30	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.26895122
31	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.24383782
32	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.23492038
33	Graft-versus-host disease_Homo sapiens_hsa05332	1.21078677
34	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.20285749
35	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.15743922
36	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.15499355
37	Phenylalanine metabolism_Homo sapiens_hsa00360	1.09052740
38	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.07074837
39	ABC transporters_Homo sapiens_hsa02010	1.06622177
40	Parkinsons disease_Homo sapiens_hsa05012	1.04746256
41	NF-kappa B signaling pathway_Homo sapiens_hsa04064	1.03216114
42	Fatty acid elongation_Homo sapiens_hsa00062	1.01060614
43	Fanconi anemia pathway_Homo sapiens_hsa03460	0.99183733
44	Sulfur metabolism_Homo sapiens_hsa00920	0.99124692
45	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.98464102
46	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.97823093
47	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.96094205
48	Fatty acid degradation_Homo sapiens_hsa00071	0.95954020
49	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.93632197
50	Allograft rejection_Homo sapiens_hsa05330	0.93460440
51	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.92425794
52	Arginine biosynthesis_Homo sapiens_hsa00220	0.91800491
53	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.89185614
54	Antigen processing and presentation_Homo sapiens_hsa04612	0.88450228
55	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.85938355
56	Fatty acid metabolism_Homo sapiens_hsa01212	0.85632007
57	Selenocompound metabolism_Homo sapiens_hsa00450	0.85576655
58	Asthma_Homo sapiens_hsa05310	0.83166262
59	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.82514984
60	Rheumatoid arthritis_Homo sapiens_hsa05323	0.81842989
61	Arginine and proline metabolism_Homo sapiens_hsa00330	0.81104394
62	DNA replication_Homo sapiens_hsa03030	0.80148443
63	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.79729864
64	Metabolic pathways_Homo sapiens_hsa01100	0.79686480
65	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.79444394
66	Legionellosis_Homo sapiens_hsa05134	0.73647556
67	Huntingtons disease_Homo sapiens_hsa05016	0.73621016
68	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.72536895
69	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.72068470
70	Purine metabolism_Homo sapiens_hsa00230	0.71767972
71	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.71707193
72	Histidine metabolism_Homo sapiens_hsa00340	0.69593653
73	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.69569850
74	Nucleotide excision repair_Homo sapiens_hsa03420	0.67110022
75	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.65163125
76	Sphingolipid metabolism_Homo sapiens_hsa00600	0.64919834
77	Herpes simplex infection_Homo sapiens_hsa05168	0.63594528
78	Retinol metabolism_Homo sapiens_hsa00830	0.63413124
79	Ribosome_Homo sapiens_hsa03010	0.62268990
80	Type I diabetes mellitus_Homo sapiens_hsa04940	0.61778474
81	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.59005027
82	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.58847932
83	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.58401094
84	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.57527237
85	Alzheimers disease_Homo sapiens_hsa05010	0.57259925
86	Base excision repair_Homo sapiens_hsa03410	0.57025837
87	Butanoate metabolism_Homo sapiens_hsa00650	0.55152238
88	Tryptophan metabolism_Homo sapiens_hsa00380	0.53385021
89	Pertussis_Homo sapiens_hsa05133	0.53341592
90	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.52829912
91	Basal transcription factors_Homo sapiens_hsa03022	0.52771779
92	Pyruvate metabolism_Homo sapiens_hsa00620	0.52632286
93	beta-Alanine metabolism_Homo sapiens_hsa00410	0.50187892
94	Malaria_Homo sapiens_hsa05144	0.49862584
95	TNF signaling pathway_Homo sapiens_hsa04668	0.48243321
96	Folate biosynthesis_Homo sapiens_hsa00790	0.47709972
97	Fat digestion and absorption_Homo sapiens_hsa04975	0.46796565
98	Mismatch repair_Homo sapiens_hsa03430	0.46595201
99	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.46405989
100	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.45531865

TEKT4P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »