TEN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: C17ORF106, or TEN1, appears to function in a telomere-associated complex with STN1 (OBFC1; MIM 613128) and CTC1 (C17ORF68; MIM 613129) (Miyake et al., 2009 [PubMed 19854130]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.09544672
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.45849747
3ATP synthesis coupled proton transport (GO:0015986)4.42342235
4energy coupled proton transport, down electrochemical gradient (GO:0015985)4.42342235
5DNA deamination (GO:0045006)4.31577114
6proteasome assembly (GO:0043248)4.21165920
7ribosomal small subunit biogenesis (GO:0042274)4.19520363
8protein complex biogenesis (GO:0070271)4.07194360
9establishment of protein localization to mitochondrial membrane (GO:0090151)4.03286140
10viral transcription (GO:0019083)4.02680666
11SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.94358955
12cotranslational protein targeting to membrane (GO:0006613)3.94019650
13mitochondrial respiratory chain complex I assembly (GO:0032981)3.89298554
14NADH dehydrogenase complex assembly (GO:0010257)3.89298554
15mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.89298554
16protein targeting to ER (GO:0045047)3.86626686
17translational termination (GO:0006415)3.85805151
18mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.83924605
19respiratory chain complex IV assembly (GO:0008535)3.78060652
20protein localization to endoplasmic reticulum (GO:0070972)3.68880014
21purine deoxyribonucleotide catabolic process (GO:0009155)3.67473569
22establishment of protein localization to endoplasmic reticulum (GO:0072599)3.65146022
23protein maturation by protein folding (GO:0022417)3.63738510
24cytochrome complex assembly (GO:0017004)3.62593128
25cellular response to zinc ion (GO:0071294)3.62271117
26mitochondrial respiratory chain complex assembly (GO:0033108)3.61317255
27chaperone-mediated protein transport (GO:0072321)3.55764141
28termination of RNA polymerase III transcription (GO:0006386)3.47830412
29transcription elongation from RNA polymerase III promoter (GO:0006385)3.47830412
30respiratory electron transport chain (GO:0022904)3.43206265
31base-excision repair, AP site formation (GO:0006285)3.39241191
32GTP biosynthetic process (GO:0006183)3.35496290
33electron transport chain (GO:0022900)3.35467558
34signal peptide processing (GO:0006465)3.35349275
35maturation of SSU-rRNA (GO:0030490)3.32020953
36deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.31911324
37antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.29889377
38neutrophil activation involved in immune response (GO:0002283)3.29005500
39translational elongation (GO:0006414)3.26915798
40antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.23361129
41response to peptidoglycan (GO:0032494)3.22011789
42deoxyribonucleotide catabolic process (GO:0009264)3.21431986
43viral life cycle (GO:0019058)3.15890398
44ribosomal large subunit biogenesis (GO:0042273)3.15148041
45deoxyribose phosphate catabolic process (GO:0046386)3.13319622
46purine nucleotide salvage (GO:0032261)3.11596869
47mannosylation (GO:0097502)3.11306920
48cellular protein complex disassembly (GO:0043624)3.08828790
49negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.08175590
50protein neddylation (GO:0045116)3.06923245
51negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.05592840
52positive regulation of prostaglandin secretion (GO:0032308)3.04642037
53translation (GO:0006412)2.99586332
54DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.97812531
55regulation of autophagic vacuole assembly (GO:2000785)2.96325817
56L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.95779846
57regulation of mitochondrial translation (GO:0070129)2.95380515
58sequestering of actin monomers (GO:0042989)2.91449926
59pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.90356691
60intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.90350584
61signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.90350584
62signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.89857014
63signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.89857014
64signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.89857014
65deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.88994651
66GPI anchor biosynthetic process (GO:0006506)2.87462750
67guanosine-containing compound biosynthetic process (GO:1901070)2.85885253
68regulation of B cell apoptotic process (GO:0002902)2.85822644
69regulation of cellular amino acid metabolic process (GO:0006521)2.85707357
70rRNA modification (GO:0000154)2.83962158
71negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.83614836
72negative regulation of ligase activity (GO:0051352)2.83614836
73pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.82635570
747-methylguanosine mRNA capping (GO:0006370)2.82278575
75negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.81220586
76protein targeting to mitochondrion (GO:0006626)2.79790018
77immunoglobulin mediated immune response (GO:0016064)2.79461198
78respiratory burst (GO:0045730)2.78400594
79RNA capping (GO:0036260)2.78343875
807-methylguanosine RNA capping (GO:0009452)2.78343875
81signal transduction involved in DNA damage checkpoint (GO:0072422)2.77486178
82signal transduction involved in DNA integrity checkpoint (GO:0072401)2.77486178
83signal transduction involved in cell cycle checkpoint (GO:0072395)2.77429044
84pentose metabolic process (GO:0019321)2.74727426
85negative regulation of B cell apoptotic process (GO:0002903)2.73943859
86cellular response to interferon-beta (GO:0035458)2.73764796
87UTP biosynthetic process (GO:0006228)2.73178383
88translational initiation (GO:0006413)2.72593796
89nucleotide salvage (GO:0043173)2.71853513
90mast cell activation (GO:0045576)2.71778361
91nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.70353746
92positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.68980566
93mature B cell differentiation involved in immune response (GO:0002313)2.67961041
94platelet dense granule organization (GO:0060155)2.67363767
95CTP metabolic process (GO:0046036)2.66952902
96CTP biosynthetic process (GO:0006241)2.66952902
97protein localization to mitochondrion (GO:0070585)2.64352336
98telomere maintenance via semi-conservative replication (GO:0032201)2.62112987
99iron-sulfur cluster assembly (GO:0016226)2.61543580
100metallo-sulfur cluster assembly (GO:0031163)2.61543580
101peptidyl-histidine modification (GO:0018202)2.61214204
102regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.59486604
103nucleoside salvage (GO:0043174)2.58125061
104regulation of vacuole organization (GO:0044088)2.57272151
105establishment of protein localization to mitochondrion (GO:0072655)2.56789352
106pseudouridine synthesis (GO:0001522)2.55800847
107pyrimidine nucleoside salvage (GO:0043097)2.55455687
108pyrimidine-containing compound salvage (GO:0008655)2.55455687
109protein complex disassembly (GO:0043241)2.55374939
110heme biosynthetic process (GO:0006783)2.54708274
111cellular component biogenesis (GO:0044085)2.54596706
112ubiquinone biosynthetic process (GO:0006744)2.53781831
113antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.53518641
1142-deoxyribonucleotide metabolic process (GO:0009394)2.52515002
115RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.50912693
116tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.50912693
117response to interferon-beta (GO:0035456)2.50040154
118protein targeting to membrane (GO:0006612)2.49913759
119cellular response to cadmium ion (GO:0071276)2.49849523
120hydrogen ion transmembrane transport (GO:1902600)2.48960651
121purine deoxyribonucleotide metabolic process (GO:0009151)2.48912084
122nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.47069667
123Arp2/3 complex-mediated actin nucleation (GO:0034314)2.45937206
124deoxyribose phosphate metabolic process (GO:0019692)2.45761848
125regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.45338501
126regulation of prostaglandin secretion (GO:0032306)2.45005401
127pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.44605080
128macromolecular complex disassembly (GO:0032984)2.44552605
129GDP-mannose metabolic process (GO:0019673)2.44416285
130cellular metabolic compound salvage (GO:0043094)2.43875591
131amyloid precursor protein catabolic process (GO:0042987)2.41818507
132anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.41122079
133oxidative phosphorylation (GO:0006119)2.40756301
134pyrimidine nucleotide catabolic process (GO:0006244)2.39785795
135exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.38151373
136purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.37679806
137positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.36915087
138GMP metabolic process (GO:0046037)2.36101526
139regulation of cellular amine metabolic process (GO:0033238)2.34908747
140positive regulation of ligase activity (GO:0051351)2.34741766
141GPI anchor metabolic process (GO:0006505)2.34544386
142viral mRNA export from host cell nucleus (GO:0046784)2.33857454
143deoxyribonucleotide metabolic process (GO:0009262)2.33753825
144proton transport (GO:0015992)2.31210560
145anterograde synaptic vesicle transport (GO:0048490)2.30430740

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.78103821
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.64984257
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.05412689
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.93423077
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.52637953
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.52391971
7BP1_19119308_ChIP-ChIP_Hs578T_Human3.51481702
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.31045635
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.04618042
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.95900364
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.93468579
12IRF8_21731497_ChIP-ChIP_J774_Mouse2.65312549
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.64271669
14ELF1_17652178_ChIP-ChIP_JURKAT_Human2.63574260
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.57052265
16IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.42844791
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.38959676
18VDR_23849224_ChIP-Seq_CD4+_Human2.36120530
19SRF_21415370_ChIP-Seq_HL-1_Mouse2.34994563
20MYC_18555785_ChIP-Seq_MESCs_Mouse2.30093800
21FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.27693187
22CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.26170128
23EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.22651290
24SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.21254132
25SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.20651533
26THAP11_20581084_ChIP-Seq_MESCs_Mouse2.18941396
27CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.15919436
28MYC_18358816_ChIP-ChIP_MESCs_Mouse2.11676236
29PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.11483200
30PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.07971087
31IRF8_22096565_ChIP-ChIP_GC-B_Human2.07656717
32HOXB4_20404135_ChIP-ChIP_EML_Mouse2.01687021
33YY1_21170310_ChIP-Seq_MESCs_Mouse2.01565055
34TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.95735669
35CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.91779280
36FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.90306835
37TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.84582773
38FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.83778318
39ELK1_19687146_ChIP-ChIP_HELA_Human1.83548816
40FOXP3_21729870_ChIP-Seq_TREG_Human1.80687051
41DCP1A_22483619_ChIP-Seq_HELA_Human1.79470206
42NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.73325451
43MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.72414173
44LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.72346376
45TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.69732965
46HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.65803997
47ERG_20887958_ChIP-Seq_HPC-7_Mouse1.62556384
48E2F1_18555785_ChIP-Seq_MESCs_Mouse1.62253445
49TFEB_21752829_ChIP-Seq_HELA_Human1.60818656
50SPI1_23547873_ChIP-Seq_NB4_Human1.58560953
51TTF2_22483619_ChIP-Seq_HELA_Human1.58403173
52MYC_19030024_ChIP-ChIP_MESCs_Mouse1.55075075
53XRN2_22483619_ChIP-Seq_HELA_Human1.47952708
54VDR_21846776_ChIP-Seq_THP-1_Human1.47608068
55STAT4_19710469_ChIP-ChIP_TH1__Mouse1.47030406
56MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.44718659
57RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.42267464
58GABP_19822575_ChIP-Seq_HepG2_Human1.42061791
59GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39663843
60ELF1_20517297_ChIP-Seq_JURKAT_Human1.39095575
61BCL6_27268052_Chip-Seq_Bcells_Human1.38314356
62ELK1_22589737_ChIP-Seq_MCF10A_Human1.35406634
63SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.35366857
64MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.33501410
65ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.32093568
66IRF1_19129219_ChIP-ChIP_H3396_Human1.31905257
67BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.30402631
68NOTCH1_21737748_ChIP-Seq_TLL_Human1.27858851
69MYC_19079543_ChIP-ChIP_MESCs_Mouse1.25146599
70DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.23590955
71TET1_21451524_ChIP-Seq_MESCs_Mouse1.22469813
72BCOR_27268052_Chip-Seq_Bcells_Human1.21923489
73TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21482075
74IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.19589178
75KDM5A_27292631_Chip-Seq_BREAST_Human1.17546137
76CTCF_26484167_Chip-Seq_Bcells_Mouse1.13853535
77MAF_26560356_Chip-Seq_TH2_Human1.12561294
78PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10333055
79MYC_18940864_ChIP-ChIP_HL60_Human1.09750893
80BMI1_23680149_ChIP-Seq_NPCS_Mouse1.09570311
81CTCF_18555785_ChIP-Seq_MESCs_Mouse1.08678438
82RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.06976215
83EGR1_23403033_ChIP-Seq_LIVER_Mouse1.06636775
84IGF1R_20145208_ChIP-Seq_DFB_Human1.05828903
85YY1_22570637_ChIP-Seq_MALME-3M_Human1.04969820
86VDR_24763502_ChIP-Seq_THP-1_Human1.04164173
87UTX_26944678_Chip-Seq_JUKART_Human1.03900112
88ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.02503134
89CIITA_25753668_ChIP-Seq_RAJI_Human1.02390212
90ZFP57_27257070_Chip-Seq_ESCs_Mouse1.01773652
91P300_27268052_Chip-Seq_Bcells_Human1.01325962
92TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00995476
93HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.00887848
94NELFA_20434984_ChIP-Seq_ESCs_Mouse1.00487024
95VDR_22108803_ChIP-Seq_LS180_Human1.00220577
96GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.00210523
97SPI1_20517297_ChIP-Seq_HL60_Human0.99731923
98CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99519653
99LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.99390794
100MYB_26560356_Chip-Seq_TH2_Human0.99084278
101ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.98310549
102E2F1_20622854_ChIP-Seq_HELA_Human0.97678219
103ELK3_25401928_ChIP-Seq_HUVEC_Human0.96194323
104E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.96075920
105MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.93506351
106SCL_19346495_ChIP-Seq_HPC-7_Human0.93368797
107ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.90847734
108FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90690198
109PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.89387814
110EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.89306621
111YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.87988727
112PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.86056959
113CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.85467855
114E2F7_22180533_ChIP-Seq_HELA_Human0.85262072
115DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.84506205
116POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.82194323
117IRF8_27001747_Chip-Seq_BMDM_Mouse0.81463303
118STAT1_20625510_ChIP-Seq_HELA_Human0.81444365
119TAF15_26573619_Chip-Seq_HEK293_Human0.80571376
120SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.80459400
121PU.1_20513432_ChIP-Seq_Bcells_Mouse0.79274375
122CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.78217756
123GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.76514309
124MYB_21317192_ChIP-Seq_ERMYB_Mouse0.75222034
125EWS_26573619_Chip-Seq_HEK293_Human0.74551534
126RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.73484857
127PCGF2_27294783_Chip-Seq_ESCs_Mouse0.73381674
128E2F4_17652178_ChIP-ChIP_JURKAT_Human0.73109226
129CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.72987207
130SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.72127566
131SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.69943001
132GATA1_22383799_ChIP-Seq_G1ME_Mouse0.69334406
133CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.69066531
134CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.67963168
135NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.67539416
136CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.67392271

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis4.33871552
2MP0009379_abnormal_foot_pigmentation3.10527197
3MP0009840_abnormal_foam_cell3.00866990
4MP0001986_abnormal_taste_sensitivity2.95135042
5MP0002148_abnormal_hypersensitivity_rea2.81850703
6MP0001835_abnormal_antigen_presentation2.71233776
7MP0003136_yellow_coat_color2.36532984
8MP0001188_hyperpigmentation2.30142165
9MP0009785_altered_susceptibility_to2.24389530
10MP0005671_abnormal_response_to2.20837168
11MP0003880_abnormal_central_pattern2.19248965
12MP0000015_abnormal_ear_pigmentation2.14279887
13MP0002837_dystrophic_cardiac_calcinosis2.13093656
14MP0002132_abnormal_respiratory_system2.10208121
15MP0000372_irregular_coat_pigmentation2.06967654
16MP0001529_abnormal_vocalization2.06579593
17MP0005174_abnormal_tail_pigmentation2.05994424
18MP0005000_abnormal_immune_tolerance2.01116372
19MP0005075_abnormal_melanosome_morpholog1.97029920
20MP0001905_abnormal_dopamine_level1.93645169
21MP0005451_abnormal_body_composition1.92235765
22MP0002638_abnormal_pupillary_reflex1.85751026
23MP0005025_abnormal_response_to1.80529475
24MP0005409_darkened_coat_color1.78263908
25MP0005171_absent_coat_pigmentation1.76781092
26MP0003724_increased_susceptibility_to1.75050226
27MP0002254_reproductive_system_inflammat1.74910392
28MP0003075_altered_response_to1.74703914
29MP0000343_altered_response_to1.74631889
30MP0003195_calcinosis1.64713041
31MP0010386_abnormal_urinary_bladder1.64511989
32MP0002723_abnormal_immune_serum1.61837384
33MP0002419_abnormal_innate_immunity1.61647715
34MP0008469_abnormal_protein_level1.60558446
35MP0006292_abnormal_olfactory_placode1.59571425
36MP0002420_abnormal_adaptive_immunity1.56779731
37MP0009333_abnormal_splenocyte_physiolog1.56689690
38MP0001819_abnormal_immune_cell1.56096477
39MP0003191_abnormal_cellular_cholesterol1.55949707
40MP0002277_abnormal_respiratory_mucosa1.55343185
41MP0002139_abnormal_hepatobiliary_system1.55131030
42MP0006035_abnormal_mitochondrial_morpho1.54486671
43MP0009764_decreased_sensitivity_to1.54319144
44MP0000490_abnormal_crypts_of1.54314848
45MP0002452_abnormal_antigen_presenting1.53730205
46MP0001533_abnormal_skeleton_physiology1.49983422
47MP0002138_abnormal_hepatobiliary_system1.48337872
48MP0005645_abnormal_hypothalamus_physiol1.47285750
49MP0002095_abnormal_skin_pigmentation1.45715627
50MP0002736_abnormal_nociception_after1.44457978
51MP0003786_premature_aging1.44289562
52MP0004381_abnormal_hair_follicle1.44050959
53MP0000920_abnormal_myelination1.40983830
54MP0001800_abnormal_humoral_immune1.40939085
55MP0002396_abnormal_hematopoietic_system1.40336617
56MP0002735_abnormal_chemical_nociception1.39528631
57MP0008260_abnormal_autophagy1.39437682
58MP0001764_abnormal_homeostasis1.39171786
59MP0008058_abnormal_DNA_repair1.37586919
60MP0002163_abnormal_gland_morphology1.36963293
61MP0004142_abnormal_muscle_tone1.33861727
62MP0002405_respiratory_system_inflammati1.33008212
63MP0001968_abnormal_touch/_nociception1.31370959
64MP0005387_immune_system_phenotype1.30047686
65MP0001790_abnormal_immune_system1.30047686
66MP0006082_CNS_inflammation1.29290343
67MP0003436_decreased_susceptibility_to1.29178125
68MP0005058_abnormal_lysosome_morphology1.28885446
69MP0003763_abnormal_thymus_physiology1.27891258
70MP0006276_abnormal_autonomic_nervous1.25727351
71MP0001984_abnormal_olfaction1.22218055
72MP0000716_abnormal_immune_system1.20461315
73MP0003303_peritoneal_inflammation1.20329868
74MP0002398_abnormal_bone_marrow1.19450112
75MP0006054_spinal_hemorrhage1.18155119
76MP0003186_abnormal_redox_activity1.17042816
77MP0005166_decreased_susceptibility_to1.16707181
78MP0005310_abnormal_salivary_gland1.14165606
79MP0004510_myositis1.13447861
80MP0003693_abnormal_embryo_hatching1.12626780
81MP0004742_abnormal_vestibular_system1.12497452
82MP0004947_skin_inflammation1.11782337
83MP0000358_abnormal_cell_content/1.10925187
84MP0001970_abnormal_pain_threshold1.10773334
85MP0005410_abnormal_fertilization1.10184658
86MP0005379_endocrine/exocrine_gland_phen1.08026396
87MP0005167_abnormal_blood-brain_barrier1.07298628
88MP0004782_abnormal_surfactant_physiolog1.06650732
89MP0002272_abnormal_nervous_system1.05344991
90MP0005319_abnormal_enzyme/_coenzyme1.05230333
91MP0000465_gastrointestinal_hemorrhage1.02861511
92MP0005397_hematopoietic_system_phenotyp1.02503019
93MP0001545_abnormal_hematopoietic_system1.02503019
94MP0005165_increased_susceptibility_to1.02167562
95MP0010155_abnormal_intestine_physiology1.01510899
96MP0002429_abnormal_blood_cell1.01439082
97MP0005365_abnormal_bile_salt1.00931898
98MP0008932_abnormal_embryonic_tissue1.00874971
99MP0000858_altered_metastatic_potential1.00195838
100MP0005360_urolithiasis1.00195263
101MP0002693_abnormal_pancreas_physiology0.99939839
102MP0005464_abnormal_platelet_physiology0.99652684
103MP0005332_abnormal_amino_acid0.98972391
104MP0000681_abnormal_thyroid_gland0.98866521
105MP0008004_abnormal_stomach_pH0.96687390
106MP0000685_abnormal_immune_system0.96176007
107MP0004147_increased_porphyrin_level0.96112776
108MP0002722_abnormal_immune_system0.95606568
109MP0003866_abnormal_defecation0.95545263
110MP0010094_abnormal_chromosome_stability0.92393873
111MP0001845_abnormal_inflammatory_respons0.92020760
112MP0000689_abnormal_spleen_morphology0.91563907
113MP0005646_abnormal_pituitary_gland0.91266142
114MP0002751_abnormal_autonomic_nervous0.88398786
115MP0009643_abnormal_urine_homeostasis0.87409741
116MP0005423_abnormal_somatic_nervous0.87375514
117MP0005330_cardiomyopathy0.87318811
118MP0008875_abnormal_xenobiotic_pharmacok0.86764503
119MP0002938_white_spotting0.86454857
120MP0009278_abnormal_bone_marrow0.85561964
121MP0001485_abnormal_pinna_reflex0.84213256
122MP0009763_increased_sensitivity_to0.83321513
123MP0002733_abnormal_thermal_nociception0.83173657
124MP0000678_abnormal_parathyroid_gland0.82895318
125MP0002102_abnormal_ear_morphology0.82623520
126MP0001853_heart_inflammation0.81499618
127MP0001963_abnormal_hearing_physiology0.81191529
128MP0008789_abnormal_olfactory_epithelium0.80899777
129MP0001542_abnormal_bone_strength0.80784292
130MP0001663_abnormal_digestive_system0.80695536
131MP0002166_altered_tumor_susceptibility0.80060516
132MP0002064_seizures0.79304991
133MP0002019_abnormal_tumor_incidence0.77473354
134MP0008873_increased_physiological_sensi0.77441560
135MP0008007_abnormal_cellular_replicative0.77436334
136MP0002734_abnormal_mechanical_nocicepti0.77079707
137MP0003172_abnormal_lysosome_physiology0.76512142
138MP0003448_altered_tumor_morphology0.74999158
139MP0006036_abnormal_mitochondrial_physio0.74220655
140MP0005636_abnormal_mineral_homeostasis0.73321131
141MP0001486_abnormal_startle_reflex0.72360493
142MP0002876_abnormal_thyroid_physiology0.72219779
143MP0000703_abnormal_thymus_morphology0.71486168
144MP0001919_abnormal_reproductive_system0.70958256
145MP0009046_muscle_twitch0.70834041
146MP0002572_abnormal_emotion/affect_behav0.70727977
147MP0003718_maternal_effect0.70691868
148MP0002006_tumorigenesis0.69023198

Predicted human phenotypes

RankGene SetZ-score
1Mitochondrial inheritance (HP:0001427)4.33324862
2Acute necrotizing encephalopathy (HP:0006965)4.31709768
3Abnormality of cells of the erythroid lineage (HP:0012130)4.19602783
4Increased hepatocellular lipid droplets (HP:0006565)4.06841110
5Abnormal number of erythroid precursors (HP:0012131)4.05451782
6Abnormal mitochondria in muscle tissue (HP:0008316)3.84213456
7Abnormality of liposaccharide metabolism (HP:0010968)3.80929549
8Abnormality of glycosphingolipid metabolism (HP:0004343)3.80929549
9Abnormality of glycolipid metabolism (HP:0010969)3.80929549
10Hepatocellular necrosis (HP:0001404)3.71032190
113-Methylglutaconic aciduria (HP:0003535)3.65530666
12Increased CSF lactate (HP:0002490)3.62377806
13Renal Fanconi syndrome (HP:0001994)3.61982087
14Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.56334482
15Progressive macrocephaly (HP:0004481)3.46755771
16Type I transferrin isoform profile (HP:0003642)3.43980336
17Lipid accumulation in hepatocytes (HP:0006561)3.41084097
18Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.36717716
19Reticulocytopenia (HP:0001896)3.14571721
20Exertional dyspnea (HP:0002875)3.11159466
21Acute encephalopathy (HP:0006846)3.07825241
22Recurrent abscess formation (HP:0002722)2.99442745
23Increased neuronal autofluorescent lipopigment (HP:0002074)2.97446926
24Hepatic necrosis (HP:0002605)2.97234296
25Increased cerebral lipofuscin (HP:0011813)2.95569679
26Elevated erythrocyte sedimentation rate (HP:0003565)2.90249657
27Petechiae (HP:0000967)2.89154805
28Aplasia/Hypoplasia of the sacrum (HP:0008517)2.77882053
29Loss of speech (HP:0002371)2.77801948
30Abnormal hair whorl (HP:0010721)2.75915570
31Hypothermia (HP:0002045)2.73997678
32Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.69632631
33Patchy hypopigmentation of hair (HP:0011365)2.69212820
34Generalized aminoaciduria (HP:0002909)2.65445162
35Cerebral hypomyelination (HP:0006808)2.60835117
36Increased intramyocellular lipid droplets (HP:0012240)2.60649566
37Increased serum lactate (HP:0002151)2.59938066
38Decreased activity of mitochondrial respiratory chain (HP:0008972)2.58022333
39Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.58022333
40Pallor (HP:0000980)2.57021650
41Cerebral edema (HP:0002181)2.54967526
42Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.50702274
43Abnormal protein N-linked glycosylation (HP:0012347)2.50702274
44Abnormal protein glycosylation (HP:0012346)2.50702274
45Abnormal glycosylation (HP:0012345)2.50702274
46Absent rod-and cone-mediated responses on ERG (HP:0007688)2.50573216
47White forelock (HP:0002211)2.50269069
48Respiratory difficulties (HP:0002880)2.48357203
49Ragged-red muscle fibers (HP:0003200)2.48251669
50Exercise intolerance (HP:0003546)2.44581884
51Microvesicular hepatic steatosis (HP:0001414)2.43925018
52Abnormality of renal resorption (HP:0011038)2.43617819
53Increased serum ferritin (HP:0003281)2.42176522
54Abnormality of dicarboxylic acid metabolism (HP:0010995)2.40269607
55Dicarboxylic aciduria (HP:0003215)2.40269607
56Dysostosis multiplex (HP:0000943)2.37516272
57Optic disc pallor (HP:0000543)2.34962024
58Leukodystrophy (HP:0002415)2.34840236
59Stomatitis (HP:0010280)2.34218826
60Macrocytic anemia (HP:0001972)2.32532510
61Abnormality of aromatic amino acid family metabolism (HP:0004338)2.31723346
62Respiratory failure (HP:0002878)2.30281981
63Abnormality of T cell physiology (HP:0011840)2.28716396
64Autoimmune thrombocytopenia (HP:0001973)2.25485416
65Obstructive lung disease (HP:0006536)2.25367711
66Chronic obstructive pulmonary disease (HP:0006510)2.25367711
67Recurrent bacterial skin infections (HP:0005406)2.24246340
68Aplastic anemia (HP:0001915)2.23983280
69Progressive neurologic deterioration (HP:0002344)2.22430199
70CNS demyelination (HP:0007305)2.18910750
71Lactic acidosis (HP:0003128)2.17156377
72Reduced antithrombin III activity (HP:0001976)2.12777937
73Myositis (HP:0100614)2.12194125
74Medial flaring of the eyebrow (HP:0010747)2.10736062
75Emotional lability (HP:0000712)2.09369273
76Poor head control (HP:0002421)2.08264415
77Testicular atrophy (HP:0000029)2.07098022
78Nausea (HP:0002018)2.06505818
79Lethargy (HP:0001254)2.06417651
80Abnormality of lateral ventricle (HP:0030047)2.04694707
81Panhypogammaglobulinemia (HP:0003139)2.02124250
82Increased muscle lipid content (HP:0009058)2.00562437
83Parakeratosis (HP:0001036)1.99945334
84Mutism (HP:0002300)1.99943519
85Autoimmune hemolytic anemia (HP:0001890)1.98081328
86Delusions (HP:0000746)1.97879229
87Vacuolated lymphocytes (HP:0001922)1.97820035
88Microretrognathia (HP:0000308)1.97280581
89Chronic mucocutaneous candidiasis (HP:0002728)1.95790669
90Recurrent cutaneous fungal infections (HP:0011370)1.95790669
91Abnormality of iron homeostasis (HP:0011031)1.95664196
92Nephrogenic diabetes insipidus (HP:0009806)1.95228410
93Congenital primary aphakia (HP:0007707)1.94557548
94Prolonged neonatal jaundice (HP:0006579)1.93967358
95Abnormal rod and cone electroretinograms (HP:0008323)1.93895328
96Hypokinesia (HP:0002375)1.93846811
97Rough bone trabeculation (HP:0100670)1.93762106
98Abnormal delayed hypersensitivity skin test (HP:0002963)1.93701809
99Abnormality of B cell number (HP:0010975)1.92503734
100B lymphocytopenia (HP:0010976)1.92503734
101IgM deficiency (HP:0002850)1.92338804
102Encephalitis (HP:0002383)1.90769417
103Gait imbalance (HP:0002141)1.90624839
104Increased IgM level (HP:0003496)1.89416763
105Abnormality of T cells (HP:0002843)1.89265607
106Opisthotonus (HP:0002179)1.87991516
107True hermaphroditism (HP:0010459)1.87850892
108Retinal dysplasia (HP:0007973)1.87238265
109Progressive microcephaly (HP:0000253)1.84705570
110Albinism (HP:0001022)1.83165928
111Severe visual impairment (HP:0001141)1.83007997
112Granulocytopenia (HP:0001913)1.82609584
113Dry hair (HP:0011359)1.82571738
114Eczematoid dermatitis (HP:0000976)1.81268217
115Axonal loss (HP:0003447)1.80556250
116Congenital ichthyosiform erythroderma (HP:0007431)1.80412212
117Prostate neoplasm (HP:0100787)1.80342359
118Type 2 muscle fiber atrophy (HP:0003554)1.78802841
119Hypertensive crisis (HP:0100735)1.78801679
120Severe combined immunodeficiency (HP:0004430)1.77537165
121Orchitis (HP:0100796)1.77396432
122Ketosis (HP:0001946)1.77034198
123Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.76492122
124Abnormality of glycosaminoglycan metabolism (HP:0004371)1.75105458
125Abnormality of macrophages (HP:0004311)1.74696422
126Pancreatic fibrosis (HP:0100732)1.72445892
127Hepatosplenomegaly (HP:0001433)1.67914232
128Increased serum pyruvate (HP:0003542)1.67607576
129Abnormality of glycolysis (HP:0004366)1.67607576
130Recurrent pneumonia (HP:0006532)1.67552256
131Neutropenia (HP:0001875)1.67339053
132Thrombocytosis (HP:0001894)1.65751566
133Abnormality of the columella (HP:0009929)1.63991680
134IgG deficiency (HP:0004315)1.63931049
135Recurrent fungal infections (HP:0002841)1.62433433
136Chromsome breakage (HP:0040012)1.62306235
137Pustule (HP:0200039)1.61820364
138Thyroiditis (HP:0100646)1.61792656
139Recurrent skin infections (HP:0001581)1.61502437
140Hypoproteinemia (HP:0003075)1.61436070
141Abnormality of the heme biosynthetic pathway (HP:0010472)1.61382786
142Abnormality of the prostate (HP:0008775)1.61095578
143Premature graying of hair (HP:0002216)1.60921963
144Congenital sensorineural hearing impairment (HP:0008527)1.59730229
145Septo-optic dysplasia (HP:0100842)1.58817980
146Pancytopenia (HP:0001876)1.58454071
147Abnormality of the preputium (HP:0100587)1.58316898
148Renal tubular dysfunction (HP:0000124)1.57607713
149Abnormality of the axillary hair (HP:0100134)1.56005666

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.02587802
2STK163.66041227
3NME23.28607904
4BCKDK2.66580554
5NME12.58136315
6CASK2.53832139
7BLK2.42454801
8MAP3K122.14792923
9TNIK2.13683166
10PIM22.12284751
11PBK2.05355574
12VRK12.04701755
13KDR1.98546939
14BUB11.98505265
15MST41.95025234
16TXK1.88417492
17IRAK41.87880498
18BMPR1B1.86564545
19MAPKAPK31.84304544
20MAPKAPK51.80825482
21ERN11.70210543
22MAP3K111.69874452
23EIF2AK31.65104720
24SIK31.65060442
25TLK11.64974972
26MARK31.59078311
27MAP3K31.58579378
28EIF2AK11.57265872
29CDK81.56254427
30ABL21.55217315
31MAP4K21.54792307
32BMPR21.51385046
33TAOK21.51204485
34CDK191.49502110
35PINK11.49275855
36GRK61.45936768
37KIT1.40256615
38TEC1.39597586
39MUSK1.37898664
40YES11.37672124
41CLK11.36323788
42PRPF4B1.34382365
43ADRBK21.33888508
44MAP3K141.28647628
45DAPK11.21657712
46GRK71.21498950
47MKNK11.19236151
48RIPK41.16913835
49SYK1.15085134
50LIMK11.12063622
51TAOK31.11618893
52ARAF1.11148959
53IRAK31.10719210
54TYK21.10455995
55DAPK31.10039926
56PRKCI1.09420392
57BRAF1.09327766
58JAK31.07880351
59DYRK21.07230775
60BTK1.07014150
61TAOK11.05368664
62MAP4K11.02684788
63CCNB11.01848251
64TBK11.01160093
65CSNK1G31.01083518
66MAP2K31.00704545
67SMG11.00564928
68EIF2AK20.97892263
69TESK20.95521479
70BCR0.93907387
71LYN0.92090802
72ERBB30.91654637
73MST1R0.90165165
74IKBKE0.89441148
75SCYL20.87944924
76MAP2K70.87881753
77OXSR10.87460097
78IKBKB0.85384160
79GRK50.83236561
80TIE10.82373378
81PIK3CA0.80170313
82LRRK20.79956867
83TGFBR10.79322869
84TAF10.78448770
85ZAP700.77558308
86MYLK0.76689021
87STK390.76392415
88MKNK20.75819060
89CDK30.74758634
90MAPK130.73678842
91GRK10.69487897
92PLK40.68999398
93ZAK0.68201942
94RPS6KA50.68136064
95TSSK60.66860538
96FES0.63315240
97PKN10.62612912
98LCK0.62596608
99CSNK1A1L0.61960275
100CSF1R0.61213189
101CSNK1G10.60076678
102ILK0.59799044
103MAP2K60.58172414
104IRAK10.56958025
105TESK10.55860779
106TRPM70.54999083
107IRAK20.54930935
108WEE10.54536568
109MAP3K50.53141528
110NUAK10.52399042
111TNK20.51395644
112CAMK2B0.50620151
113MATK0.50240997
114PRKCD0.48327758
115AURKA0.48255468
116DYRK30.47786959
117MAP2K20.45693070
118PRKCQ0.44996571
119PIM10.41967511
120CSNK2A10.41438283
121FGR0.41424211
122SRPK10.40465600
123NLK0.40335040
124CAMK2D0.40266393
125PAK10.40245890
126CAMKK20.40220980
127NEK10.39982103
128PASK0.39640979
129PAK40.39600631
130ACVR1B0.39596933
131MAP3K10.39373913
132ADRBK10.39207648
133STK240.39059401
134CSNK1G20.38293204
135MAP3K80.35672766
136UHMK10.35666792
137FLT30.35651625
138STK100.35648851
139RPS6KA60.35536131
140CSK0.35463154
141CDK90.31197904
142ITK0.31046860

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.04106964
2Oxidative phosphorylation_Homo sapiens_hsa001903.69442304
3Proteasome_Homo sapiens_hsa030503.53300342
4Protein export_Homo sapiens_hsa030603.31984373
5Parkinsons disease_Homo sapiens_hsa050123.03575728
6RNA polymerase_Homo sapiens_hsa030202.81077605
7Alzheimers disease_Homo sapiens_hsa050102.32561161
8Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.31616764
9Huntingtons disease_Homo sapiens_hsa050162.24668457
10DNA replication_Homo sapiens_hsa030302.12574508
11Mismatch repair_Homo sapiens_hsa034302.00181792
12Homologous recombination_Homo sapiens_hsa034401.95194623
13Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.86186471
14Pyrimidine metabolism_Homo sapiens_hsa002401.78867431
15SNARE interactions in vesicular transport_Homo sapiens_hsa041301.71535711
16Base excision repair_Homo sapiens_hsa034101.68173731
17Sulfur relay system_Homo sapiens_hsa041221.59555454
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.59175870
19Non-homologous end-joining_Homo sapiens_hsa034501.48375631
20Nucleotide excision repair_Homo sapiens_hsa034201.47059188
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.44548318
22Spliceosome_Homo sapiens_hsa030401.41657672
23Rheumatoid arthritis_Homo sapiens_hsa053231.33729761
24Collecting duct acid secretion_Homo sapiens_hsa049661.33209404
25Primary immunodeficiency_Homo sapiens_hsa053401.31403566
26Basal transcription factors_Homo sapiens_hsa030221.28415690
27Vibrio cholerae infection_Homo sapiens_hsa051101.19579530
28Fanconi anemia pathway_Homo sapiens_hsa034601.16410564
29Arachidonic acid metabolism_Homo sapiens_hsa005901.13821007
30Purine metabolism_Homo sapiens_hsa002301.12325097
31Graft-versus-host disease_Homo sapiens_hsa053321.12250934
32Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.11681254
33Allograft rejection_Homo sapiens_hsa053301.08526364
34Asthma_Homo sapiens_hsa053101.07127118
35Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.06892357
36Staphylococcus aureus infection_Homo sapiens_hsa051501.06847886
37Phagosome_Homo sapiens_hsa041451.02668394
38Cardiac muscle contraction_Homo sapiens_hsa042600.99214807
39Cysteine and methionine metabolism_Homo sapiens_hsa002700.98739998
40Galactose metabolism_Homo sapiens_hsa000520.97936691
41Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.95593156
42Other glycan degradation_Homo sapiens_hsa005110.93889978
43Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.93095666
44Drug metabolism - other enzymes_Homo sapiens_hsa009830.92968789
45Autoimmune thyroid disease_Homo sapiens_hsa053200.91565124
46Pentose phosphate pathway_Homo sapiens_hsa000300.91425661
47Ether lipid metabolism_Homo sapiens_hsa005650.90496613
48Hematopoietic cell lineage_Homo sapiens_hsa046400.89275544
49Intestinal immune network for IgA production_Homo sapiens_hsa046720.88105138
50Sphingolipid metabolism_Homo sapiens_hsa006000.87379845
51Peroxisome_Homo sapiens_hsa041460.87217314
52Primary bile acid biosynthesis_Homo sapiens_hsa001200.84962026
53Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.84503385
54Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.84205110
55Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.80725428
56Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.78119273
57Leishmaniasis_Homo sapiens_hsa051400.76083529
58Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.75862181
59RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.75583537
60Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.74363008
61Serotonergic synapse_Homo sapiens_hsa047260.72474018
62RNA degradation_Homo sapiens_hsa030180.71959249
63Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.71942045
64Type I diabetes mellitus_Homo sapiens_hsa049400.71824532
65Lysosome_Homo sapiens_hsa041420.71041865
66Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.71021565
67Glycosaminoglycan degradation_Homo sapiens_hsa005310.71009106
68Legionellosis_Homo sapiens_hsa051340.70009400
69Pyruvate metabolism_Homo sapiens_hsa006200.69555986
70N-Glycan biosynthesis_Homo sapiens_hsa005100.69548966
71Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.69398996
72NOD-like receptor signaling pathway_Homo sapiens_hsa046210.69283019
73One carbon pool by folate_Homo sapiens_hsa006700.69126018
74Fructose and mannose metabolism_Homo sapiens_hsa000510.69012671
75Regulation of autophagy_Homo sapiens_hsa041400.67856125
76Tryptophan metabolism_Homo sapiens_hsa003800.67215904
77Pertussis_Homo sapiens_hsa051330.66899337
78Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.66257226
79NF-kappa B signaling pathway_Homo sapiens_hsa040640.66146430
80Epstein-Barr virus infection_Homo sapiens_hsa051690.65047735
81Salmonella infection_Homo sapiens_hsa051320.64783271
82Shigellosis_Homo sapiens_hsa051310.64318140
83Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.63938271
84Tuberculosis_Homo sapiens_hsa051520.63096932
85Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.61748136
86Mineral absorption_Homo sapiens_hsa049780.61083540
87Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.60439853
88Measles_Homo sapiens_hsa051620.59536584
89Synaptic vesicle cycle_Homo sapiens_hsa047210.59106180
90Linoleic acid metabolism_Homo sapiens_hsa005910.58978465
91Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.58222737
92Phototransduction_Homo sapiens_hsa047440.57780340
93Pentose and glucuronate interconversions_Homo sapiens_hsa000400.57481918
94Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.57446038
95Viral myocarditis_Homo sapiens_hsa054160.57186130
96Antigen processing and presentation_Homo sapiens_hsa046120.56448177
97Osteoclast differentiation_Homo sapiens_hsa043800.55773282
98Taste transduction_Homo sapiens_hsa047420.54257093
99Toll-like receptor signaling pathway_Homo sapiens_hsa046200.54227367
100Carbon metabolism_Homo sapiens_hsa012000.53715663
101Fatty acid degradation_Homo sapiens_hsa000710.52834525
102Vitamin B6 metabolism_Homo sapiens_hsa007500.52590761
103Chemical carcinogenesis_Homo sapiens_hsa052040.52161090
104Malaria_Homo sapiens_hsa051440.51491650
105Folate biosynthesis_Homo sapiens_hsa007900.49979299
106RNA transport_Homo sapiens_hsa030130.49785197
107Herpes simplex infection_Homo sapiens_hsa051680.49504340
1082-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.48667389
109Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48132539
110African trypanosomiasis_Homo sapiens_hsa051430.45720706
111Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.44431781
112Maturity onset diabetes of the young_Homo sapiens_hsa049500.42308231
113Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.41822163
114Alcoholism_Homo sapiens_hsa050340.40097945
115Metabolic pathways_Homo sapiens_hsa011000.40080288
116alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.38624329
117Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37988688
118B cell receptor signaling pathway_Homo sapiens_hsa046620.34601314
119Apoptosis_Homo sapiens_hsa042100.32771508
120Influenza A_Homo sapiens_hsa051640.31914083
121Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.31702129
122Cell cycle_Homo sapiens_hsa041100.31660753
123Sulfur metabolism_Homo sapiens_hsa009200.31550364
124Systemic lupus erythematosus_Homo sapiens_hsa053220.30245768
125Fatty acid elongation_Homo sapiens_hsa000620.30223799
126Jak-STAT signaling pathway_Homo sapiens_hsa046300.28347872
127Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.27862337
128Chemokine signaling pathway_Homo sapiens_hsa040620.27623157
129Nicotine addiction_Homo sapiens_hsa050330.27367475
130Glutathione metabolism_Homo sapiens_hsa004800.26136201
131Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.26109781

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