TEN1-CDK3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This locus represents naturally occurring read-through transcription between the neighboring TEN1 telomerase capping complex subunit homolog (S. cerevisiae) and cyclin-dependent kinase 3 (CDK3) genes. The read-through transcript is a candidate for nonsense-mediated mRNA decay (NMD), and is therefore unlikely to produce a protein product. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.57257217
2piRNA metabolic process (GO:0034587)5.03301201
3fucose catabolic process (GO:0019317)4.83930775
4L-fucose metabolic process (GO:0042354)4.83930775
5L-fucose catabolic process (GO:0042355)4.83930775
6DNA methylation involved in gamete generation (GO:0043046)4.10362272
7positive regulation of fatty acid transport (GO:2000193)3.94487453
8DNA deamination (GO:0045006)3.90942329
9regulation of hippo signaling (GO:0035330)3.82575822
10male meiosis (GO:0007140)3.80434999
11indolalkylamine catabolic process (GO:0046218)3.79970101
12tryptophan catabolic process (GO:0006569)3.79970101
13indole-containing compound catabolic process (GO:0042436)3.79970101
14positive regulation of icosanoid secretion (GO:0032305)3.79449499
15indolalkylamine metabolic process (GO:0006586)3.66094699
16regulation of posttranscriptional gene silencing (GO:0060147)3.63076570
17regulation of gene silencing by miRNA (GO:0060964)3.63076570
18regulation of gene silencing by RNA (GO:0060966)3.63076570
19positive regulation of prostaglandin secretion (GO:0032308)3.62441582
20axoneme assembly (GO:0035082)3.57805704
21protein polyglutamylation (GO:0018095)3.50100643
22male meiosis I (GO:0007141)3.45295053
23opioid receptor signaling pathway (GO:0038003)3.39827340
24mannosylation (GO:0097502)3.39184290
25response to pheromone (GO:0019236)3.36005910
26preassembly of GPI anchor in ER membrane (GO:0016254)3.30905920
27water-soluble vitamin biosynthetic process (GO:0042364)3.28531056
28kynurenine metabolic process (GO:0070189)3.23165124
29tryptophan metabolic process (GO:0006568)3.22973362
30adaptation of signaling pathway (GO:0023058)3.17739688
31detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.15896826
32positive regulation of defense response to virus by host (GO:0002230)3.14292231
33NAD biosynthetic process (GO:0009435)3.09397791
34glycerophospholipid catabolic process (GO:0046475)3.07288217
35fucosylation (GO:0036065)3.01394280
36cellular response to exogenous dsRNA (GO:0071360)2.95477596
37negative regulation of telomere maintenance (GO:0032205)2.92421920
38epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.90124798
39cornea development in camera-type eye (GO:0061303)2.90102099
40cellular response to ATP (GO:0071318)2.88503655
41negative regulation of T cell differentiation in thymus (GO:0033085)2.85884575
42synapsis (GO:0007129)2.83091336
43negative regulation of mast cell activation (GO:0033004)2.78559674
44meiotic chromosome segregation (GO:0045132)2.72643375
45cellular biogenic amine catabolic process (GO:0042402)2.71611100
46amine catabolic process (GO:0009310)2.71611100
47sulfation (GO:0051923)2.69452638
48synaptic transmission, cholinergic (GO:0007271)2.69405697
49regulation of icosanoid secretion (GO:0032303)2.68830950
50indole-containing compound metabolic process (GO:0042430)2.68802535
51S-adenosylmethionine metabolic process (GO:0046500)2.68412856
52cellular ketone body metabolic process (GO:0046950)2.67446802
53GPI anchor metabolic process (GO:0006505)2.64554294
54platelet dense granule organization (GO:0060155)2.64529964
55regulation of prostaglandin secretion (GO:0032306)2.63632462
56respiratory chain complex IV assembly (GO:0008535)2.61493173
57neuronal action potential (GO:0019228)2.61454798
58response to misfolded protein (GO:0051788)2.60624428
59mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.60524959
60mitochondrial respiratory chain complex I assembly (GO:0032981)2.60524959
61NADH dehydrogenase complex assembly (GO:0010257)2.60524959
62protein complex biogenesis (GO:0070271)2.59941269
63cytochrome complex assembly (GO:0017004)2.59777718
64cellular extravasation (GO:0045123)2.59491312
65negative regulation of Rho protein signal transduction (GO:0035024)2.58095131
66phosphatidylinositol acyl-chain remodeling (GO:0036149)2.57095358
67negative regulation of macroautophagy (GO:0016242)2.55194532
68cAMP catabolic process (GO:0006198)2.54629691
69reciprocal DNA recombination (GO:0035825)2.53522185
70reciprocal meiotic recombination (GO:0007131)2.53522185
71rRNA methylation (GO:0031167)2.53428857
72replication fork processing (GO:0031297)2.51451146
73positive regulation of organic acid transport (GO:0032892)2.49904345
74sulfate transmembrane transport (GO:1902358)2.49714789
75detection of light stimulus involved in sensory perception (GO:0050962)2.48730951
76detection of light stimulus involved in visual perception (GO:0050908)2.48730951
77negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.48524640
78positive regulation of uterine smooth muscle contraction (GO:0070474)2.47820043
79meiosis I (GO:0007127)2.47259982
80protein localization to cilium (GO:0061512)2.46643454
81fucose metabolic process (GO:0006004)2.45348319
82nonmotile primary cilium assembly (GO:0035058)2.44649091
83regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.44507449
84endoderm formation (GO:0001706)2.42448076
85base-excision repair, AP site formation (GO:0006285)2.41212875
86alkaloid metabolic process (GO:0009820)2.40384216
87inositol phosphate catabolic process (GO:0071545)2.39534422
88phosphorylated carbohydrate dephosphorylation (GO:0046838)2.38657594
89inositol phosphate dephosphorylation (GO:0046855)2.38657594
90GPI anchor biosynthetic process (GO:0006506)2.38519794
91pyridine nucleotide biosynthetic process (GO:0019363)2.37824313
92nicotinamide nucleotide biosynthetic process (GO:0019359)2.37824313
93interferon-gamma production (GO:0032609)2.36279780
94regulation of defense response to virus by host (GO:0050691)2.35614431
95regulation of nuclear cell cycle DNA replication (GO:0033262)2.35613691
96mitochondrial respiratory chain complex assembly (GO:0033108)2.35590543
97oxidative demethylation (GO:0070989)2.35280057
98phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.35161274
99positive regulation of triglyceride biosynthetic process (GO:0010867)2.34081455
100seminiferous tubule development (GO:0072520)2.33966582

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela4.48035447
2VDR_22108803_ChIP-Seq_LS180_Human3.74613104
3IRF8_22096565_ChIP-ChIP_GC-B_Human2.92378107
4EZH2_22144423_ChIP-Seq_EOC_Human2.63476186
5NOTCH1_21737748_ChIP-Seq_TLL_Human2.39148706
6GBX2_23144817_ChIP-Seq_PC3_Human2.37634812
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.34902291
8ER_23166858_ChIP-Seq_MCF-7_Human2.06787153
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.05020588
10CTBP1_25329375_ChIP-Seq_LNCAP_Human1.90230470
11EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.86898794
12IGF1R_20145208_ChIP-Seq_DFB_Human1.80565498
13EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.75796363
14ZFP57_27257070_Chip-Seq_ESCs_Mouse1.70132088
15IRF1_19129219_ChIP-ChIP_H3396_Human1.70066824
16EWS_26573619_Chip-Seq_HEK293_Human1.69741379
17CTBP2_25329375_ChIP-Seq_LNCAP_Human1.67229307
18FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.62798969
19GATA3_21878914_ChIP-Seq_MCF-7_Human1.61946791
20ETV2_25802403_ChIP-Seq_MESCs_Mouse1.61776707
21FLI1_27457419_Chip-Seq_LIVER_Mouse1.61026230
22BCAT_22108803_ChIP-Seq_LS180_Human1.60007755
23TP53_22573176_ChIP-Seq_HFKS_Human1.56798776
24LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.56591199
25CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.55711325
26ERA_21632823_ChIP-Seq_H3396_Human1.53498781
27RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.52047318
28HOXB7_26014856_ChIP-Seq_BT474_Human1.49015800
29FUS_26573619_Chip-Seq_HEK293_Human1.48551105
30CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.46312102
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.44787529
32AR_20517297_ChIP-Seq_VCAP_Human1.42725299
33GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.42182265
34SRF_21415370_ChIP-Seq_HL-1_Mouse1.39879565
35EGR1_23403033_ChIP-Seq_LIVER_Mouse1.38793350
36OCT4_20526341_ChIP-Seq_ESCs_Human1.38258097
37IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.36772260
38GATA3_26560356_Chip-Seq_TH2_Human1.34683653
39JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.34026380
40GABP_17652178_ChIP-ChIP_JURKAT_Human1.33704501
41PCGF2_27294783_Chip-Seq_ESCs_Mouse1.33274106
42MYC_19829295_ChIP-Seq_ESCs_Human1.32628809
43FOXA1_27270436_Chip-Seq_PROSTATE_Human1.29489378
44FOXA1_25329375_ChIP-Seq_VCAP_Human1.29489378
45EST1_17652178_ChIP-ChIP_JURKAT_Human1.28672385
46RAC3_21632823_ChIP-Seq_H3396_Human1.27448635
47UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.27139265
48NANOG_20526341_ChIP-Seq_ESCs_Human1.27129224
49MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.27011936
50TAF2_19829295_ChIP-Seq_ESCs_Human1.24854219
51POU3F2_20337985_ChIP-ChIP_501MEL_Human1.24121881
52NCOR_22424771_ChIP-Seq_293T_Human1.23902948
53MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.23587791
54REST_21632747_ChIP-Seq_MESCs_Mouse1.23540791
55MYC_18940864_ChIP-ChIP_HL60_Human1.23353633
56VDR_23849224_ChIP-Seq_CD4+_Human1.23300425
57PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.23210003
58CBP_20019798_ChIP-Seq_JUKART_Human1.23028472
59IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.23028472
60VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.21628957
61BCL6_27268052_Chip-Seq_Bcells_Human1.20820184
62E2F1_20622854_ChIP-Seq_HELA_Human1.20220720
63NANOG_19829295_ChIP-Seq_ESCs_Human1.18627461
64SOX2_19829295_ChIP-Seq_ESCs_Human1.18627461
65P300_19829295_ChIP-Seq_ESCs_Human1.18544850
66RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.17062374
67EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.16432791
68FOXH1_21741376_ChIP-Seq_ESCs_Human1.16001541
69TCF4_23295773_ChIP-Seq_U87_Human1.13224688
70IKZF1_21737484_ChIP-ChIP_HCT116_Human1.12906138
71TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.11381811
72P53_21459846_ChIP-Seq_SAOS-2_Human1.10369038
73CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.06974255
74P300_27268052_Chip-Seq_Bcells_Human1.06619196
75PRDM14_20953172_ChIP-Seq_ESCs_Human1.06555154
76PHF8_20622854_ChIP-Seq_HELA_Human1.06424990
77TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05342830
78FOXH1_21741376_ChIP-Seq_EPCs_Human1.03800892
79AR_25329375_ChIP-Seq_VCAP_Human1.03356200
80EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.03112823
81POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.02925027
82TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02925027
83KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.02910559
84FOXA1_21572438_ChIP-Seq_LNCaP_Human1.02608552
85STAT3_23295773_ChIP-Seq_U87_Human1.01432536
86RUNX2_22187159_ChIP-Seq_PCA_Human1.00882570
87NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00769284
88TCF4_22108803_ChIP-Seq_LS180_Human0.99756121
89KLF5_20875108_ChIP-Seq_MESCs_Mouse0.98229860
90CTCF_20526341_ChIP-Seq_ESCs_Human0.97169352
91BCOR_27268052_Chip-Seq_Bcells_Human0.97078377
92FLI1_21867929_ChIP-Seq_TH2_Mouse0.96946310
93GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.95669234
94CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.95342653
95E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.94915871
96RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93387488
97YY1_22570637_ChIP-Seq_MALME-3M_Human0.93283791
98IRF8_21731497_ChIP-ChIP_J774_Mouse0.93148986
99NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.93098032
100PCGF2_27294783_Chip-Seq_NPCs_Mouse0.92433480

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation4.17513518
2MP0003195_calcinosis3.21496836
3MP0003787_abnormal_imprinting3.02485403
4MP0008875_abnormal_xenobiotic_pharmacok2.87794792
5MP0003806_abnormal_nucleotide_metabolis2.60623742
6MP0003646_muscle_fatigue2.39398627
7MP0005174_abnormal_tail_pigmentation2.26307122
8MP0001986_abnormal_taste_sensitivity2.23081417
9MP0002876_abnormal_thyroid_physiology2.15386319
10MP0005551_abnormal_eye_electrophysiolog2.13077009
11MP0008872_abnormal_physiological_respon2.06772410
12MP0004885_abnormal_endolymph2.04728217
13MP0004147_increased_porphyrin_level1.85158492
14MP0006072_abnormal_retinal_apoptosis1.81641674
15MP0002837_dystrophic_cardiac_calcinosis1.76297232
16MP0002102_abnormal_ear_morphology1.68182262
17MP0005671_abnormal_response_to1.65395611
18MP0005360_urolithiasis1.63314983
19MP0001968_abnormal_touch/_nociception1.62562674
20MP0005389_reproductive_system_phenotype1.62492153
21MP0001919_abnormal_reproductive_system1.57398193
22MP0002928_abnormal_bile_duct1.53281702
23MP0000569_abnormal_digit_pigmentation1.52656248
24MP0000685_abnormal_immune_system1.52443101
25MP0004043_abnormal_pH_regulation1.51589500
26MP0001764_abnormal_homeostasis1.51577165
27MP0002148_abnormal_hypersensitivity_rea1.51488365
28MP0005365_abnormal_bile_salt1.50822252
29MP0002160_abnormal_reproductive_system1.49498825
30MP0004142_abnormal_muscle_tone1.47590647
31MP0001501_abnormal_sleep_pattern1.47491687
32MP0000427_abnormal_hair_cycle1.47405744
33MP0005075_abnormal_melanosome_morpholog1.46039228
34MP0002254_reproductive_system_inflammat1.43925048
35MP0004133_heterotaxia1.42341751
36MP0005310_abnormal_salivary_gland1.41233823
37MP0005646_abnormal_pituitary_gland1.41192540
38MP0004742_abnormal_vestibular_system1.39412817
39MP0003011_delayed_dark_adaptation1.35349336
40MP0005253_abnormal_eye_physiology1.33649114
41MP0002138_abnormal_hepatobiliary_system1.33403988
42MP0005085_abnormal_gallbladder_physiolo1.30531505
43MP0002653_abnormal_ependyma_morphology1.29205845
44MP0003724_increased_susceptibility_to1.27900116
45MP0009745_abnormal_behavioral_response1.25659535
46MP0003121_genomic_imprinting1.24493884
47MP0006292_abnormal_olfactory_placode1.23480585
48MP0002272_abnormal_nervous_system1.19795295
49MP0003136_yellow_coat_color1.19536954
50MP0000230_abnormal_systemic_arterial1.18373951
51MP0005167_abnormal_blood-brain_barrier1.18181398
52MP0005332_abnormal_amino_acid1.18066507
53MP0002938_white_spotting1.17344163
54MP0001800_abnormal_humoral_immune1.17135829
55MP0002693_abnormal_pancreas_physiology1.16239618
56MP0005410_abnormal_fertilization1.16184151
57MP0000538_abnormal_urinary_bladder1.15774903
58MP0001835_abnormal_antigen_presentation1.14522552
59MP0002210_abnormal_sex_determination1.11588259
60MP0001661_extended_life_span1.11293023
61MP0003283_abnormal_digestive_organ1.09155796
62MP0009046_muscle_twitch1.08886696
63MP0001485_abnormal_pinna_reflex1.08439696
64MP0002909_abnormal_adrenal_gland1.08182427
65MP0001929_abnormal_gametogenesis1.07461459
66MP0002638_abnormal_pupillary_reflex1.06295622
67MP0003698_abnormal_male_reproductive1.02039774
68MP0002736_abnormal_nociception_after1.00390453
69MP0002723_abnormal_immune_serum0.99917282
70MP0010329_abnormal_lipoprotein_level0.97943659
71MP0001145_abnormal_male_reproductive0.97205697
72MP0008995_early_reproductive_senescence0.96901699
73MP0008058_abnormal_DNA_repair0.96542593
74MP0001502_abnormal_circadian_rhythm0.95334369
75MP0003436_decreased_susceptibility_to0.94917882
76MP0005195_abnormal_posterior_eye0.94215003
77MP0000470_abnormal_stomach_morphology0.94019483
78MP0002277_abnormal_respiratory_mucosa0.93859113
79MP0000653_abnormal_sex_gland0.91931303
80MP0003252_abnormal_bile_duct0.91615396
81MP0001790_abnormal_immune_system0.89962588
82MP0005387_immune_system_phenotype0.89962588
83MP0003172_abnormal_lysosome_physiology0.89749768
84MP0008775_abnormal_heart_ventricle0.89213826
85MP0009764_decreased_sensitivity_to0.86411164
86MP0006035_abnormal_mitochondrial_morpho0.84495932
87MP0001663_abnormal_digestive_system0.84398607
88MP0002420_abnormal_adaptive_immunity0.83584888
89MP0001819_abnormal_immune_cell0.82932682
90MP0001970_abnormal_pain_threshold0.82684850
91MP0009785_altered_susceptibility_to0.80736497
92MP0002452_abnormal_antigen_presenting0.78108153
93MP0004019_abnormal_vitamin_homeostasis0.77683303
94MP0002229_neurodegeneration0.77566262
95MP0001873_stomach_inflammation0.77435406
96MP0005647_abnormal_sex_gland0.77339206
97MP0000015_abnormal_ear_pigmentation0.76108599
98MP0005377_hearing/vestibular/ear_phenot0.75919742
99MP0003878_abnormal_ear_physiology0.75919742
100MP0002064_seizures0.75212756

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of midbrain morphology (HP:0002418)4.07551770
2Molar tooth sign on MRI (HP:0002419)4.07551770
3Type II lissencephaly (HP:0007260)3.92490604
4Congenital stationary night blindness (HP:0007642)3.82017192
5Pancreatic fibrosis (HP:0100732)3.70757795
6Pancreatic cysts (HP:0001737)3.57252246
7Nephronophthisis (HP:0000090)3.50599983
8Abnormality of the renal medulla (HP:0100957)3.20772226
9Attenuation of retinal blood vessels (HP:0007843)3.08956115
10True hermaphroditism (HP:0010459)2.87986339
11Pendular nystagmus (HP:0012043)2.81681828
12Hypoplasia of the pons (HP:0012110)2.81548334
13Abnormality of the renal cortex (HP:0011035)2.79079933
14Abolished electroretinogram (ERG) (HP:0000550)2.78270034
15Chronic hepatic failure (HP:0100626)2.77610441
16Stomach cancer (HP:0012126)2.70521579
17Abnormality of the pons (HP:0007361)2.69114785
18Abnormal rod and cone electroretinograms (HP:0008323)2.66443432
19Clumsiness (HP:0002312)2.65410032
20Mesangial abnormality (HP:0001966)2.65369984
21Inability to walk (HP:0002540)2.65280650
22Cerebellar dysplasia (HP:0007033)2.56843210
23Stomatitis (HP:0010280)2.54910296
24Decreased electroretinogram (ERG) amplitude (HP:0000654)2.53204471
25Large for gestational age (HP:0001520)2.53011579
26Hyperventilation (HP:0002883)2.50778039
27Retinal dysplasia (HP:0007973)2.50511251
28Tubular atrophy (HP:0000092)2.45937303
29Medial flaring of the eyebrow (HP:0010747)2.44538689
30Cystic liver disease (HP:0006706)2.42788272
31Progressive inability to walk (HP:0002505)2.33355680
32Panhypogammaglobulinemia (HP:0003139)2.33321717
33Aplasia/Hypoplasia of the tibia (HP:0005772)2.31518226
34Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.29733213
35Increased neuronal autofluorescent lipopigment (HP:0002074)2.29124785
36Absent rod-and cone-mediated responses on ERG (HP:0007688)2.28356265
37Abnormal drinking behavior (HP:0030082)2.24953943
38Polydipsia (HP:0001959)2.24953943
39Chorioretinal atrophy (HP:0000533)2.20610074
40Fair hair (HP:0002286)2.18829030
41Hypoalbuminemia (HP:0003073)2.16390609
42Abnormal albumin level (HP:0012116)2.16390609
43Severe muscular hypotonia (HP:0006829)2.16113958
44Pachygyria (HP:0001302)2.13085303
45Ketosis (HP:0001946)2.07860219
46IgG deficiency (HP:0004315)2.06281977
47Congenital hepatic fibrosis (HP:0002612)2.04821776
48Patellar aplasia (HP:0006443)2.03945767
49Polyuria (HP:0000103)2.02563249
50Protruding tongue (HP:0010808)2.02465128
51Aplasia/Hypoplasia of the patella (HP:0006498)2.01857088
52Lissencephaly (HP:0001339)1.99207690
53Male pseudohermaphroditism (HP:0000037)1.99010538
54Abnormality of lateral ventricle (HP:0030047)1.98423190
55Broad-based gait (HP:0002136)1.97250675
56Abnormality of alanine metabolism (HP:0010916)1.96035327
57Hyperalaninemia (HP:0003348)1.96035327
58Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.96035327
59Renal cortical cysts (HP:0000803)1.95945420
60Recurrent cutaneous fungal infections (HP:0011370)1.94264385
61Chronic mucocutaneous candidiasis (HP:0002728)1.94264385
62Gaze-evoked nystagmus (HP:0000640)1.94252871
63Hypoproteinemia (HP:0003075)1.93768064
64Decreased circulating renin level (HP:0003351)1.92901347
65Abnormal delayed hypersensitivity skin test (HP:0002963)1.92258174
66Absent speech (HP:0001344)1.90268481
67Thyroiditis (HP:0100646)1.88602646
68Decreased central vision (HP:0007663)1.88120319
69Anterior segment dysgenesis (HP:0007700)1.87351035
70Absent thumb (HP:0009777)1.86248471
71Short tibia (HP:0005736)1.84752876
72Furrowed tongue (HP:0000221)1.82658685
73Progressive microcephaly (HP:0000253)1.82075366
743-Methylglutaconic aciduria (HP:0003535)1.81295557
75Sclerocornea (HP:0000647)1.80118477
76Mitochondrial inheritance (HP:0001427)1.79285326
77Opisthotonus (HP:0002179)1.79258659
78Abnormal biliary tract physiology (HP:0012439)1.78916290
79Bile duct proliferation (HP:0001408)1.78916290
80Metaphyseal dysplasia (HP:0100255)1.78457683
81Adactyly (HP:0009776)1.76888935
82Increased CSF lactate (HP:0002490)1.73584588
83Disproportionate short-trunk short stature (HP:0003521)1.72844428
84Aplasia/hypoplasia of the uterus (HP:0008684)1.72813409
85Aplasia/Hypoplasia of the tongue (HP:0010295)1.72752400
86Rib fusion (HP:0000902)1.72532945
87Bony spicule pigmentary retinopathy (HP:0007737)1.72442695
88Aplasia/Hypoplasia of the spleen (HP:0010451)1.71382028
89Median cleft lip (HP:0000161)1.70763674
90Congenital sensorineural hearing impairment (HP:0008527)1.69450564
91Macular degeneration (HP:0000608)1.69303423
92Congenital, generalized hypertrichosis (HP:0004540)1.68525058
93Abnormality of B cell number (HP:0010975)1.68354838
94Severe visual impairment (HP:0001141)1.68326158
95Hemiparesis (HP:0001269)1.66815379
96Increased cerebral lipofuscin (HP:0011813)1.66130905
97Limb hypertonia (HP:0002509)1.65348735
98Tachypnea (HP:0002789)1.65287055
99Elevated erythrocyte sedimentation rate (HP:0003565)1.64623108
100Methylmalonic aciduria (HP:0012120)1.62660299

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.64782706
2TAOK34.86259060
3TLK13.52984180
4BMPR1B3.39810731
5ADRBK23.35781853
6ACVR1B2.98825979
7MAP4K22.42885096
8PINK12.24663286
9GRK12.20390207
10TAF12.16778961
11NUAK12.03640271
12TXK1.98047595
13ZAK1.87782486
14CAMKK21.69431611
15GRK61.66200431
16WNK31.61051419
17MAPK151.57111721
18DAPK21.56048355
19MAPK131.52156147
20TNIK1.49759809
21WNK41.44923113
22IKBKB1.42860473
23TGFBR11.34404757
24INSRR1.22361615
25MAP4K11.20966312
26FGFR21.20322615
27SIK21.17798039
28MAP2K61.13864516
29ADRBK11.11824291
30TNK21.11436693
31MATK1.09406335
32KIT1.09320507
33BCKDK1.08101535
34PTK2B1.08074972
35TIE11.07193063
36NEK21.01561343
37TEC0.92761355
38NTRK20.90887898
39PHKG20.90361701
40PHKG10.90361701
41ZAP700.89549477
42CHUK0.88716656
43OXSR10.85652883
44SYK0.83663368
45PRKCI0.82851836
46MARK30.82495158
47MAP2K20.81672604
48STK110.81368483
49NTRK30.76895540
50BRSK20.73342798
51ITK0.70861239
52DYRK20.70736619
53IKBKE0.67883735
54CAMK1D0.64700607
55IRAK40.63927676
56MAP3K40.60477581
57FLT30.59699781
58CAMK1G0.57457522
59LYN0.56874781
60MAPK70.55156162
61PRKCQ0.54282170
62JAK30.52588615
63GRK70.52552127
64CDK80.51343071
65LCK0.51142561
66BTK0.49962291
67MAPK120.49042534
68PNCK0.48569109
69HIPK20.48194658
70NME10.48047060
71CDK30.47126299
72RPS6KA60.46001572
73MST40.44483523
74TBK10.41963232
75CASK0.41170258
76CCNB10.41107953
77PRKCG0.40846740
78PRKD20.40404634
79MAPKAPK30.39814874
80PRKAA10.38896718
81CSNK1G20.38604786
82PRKCE0.37633109
83PRKAA20.37412520
84VRK10.35567971
85STK390.35410126
86MAP2K70.35258065
87MAP3K110.34761554
88RPS6KA50.34370490
89ERBB20.34187491
90CSF1R0.33520828
91NTRK10.32188535
92FES0.31521784
93CAMK10.31116126
94PRKACA0.31043591
95PIK3CA0.29669757
96PKN10.29434510
97CSNK1A10.28671322
98ABL10.28477720
99MKNK20.28044007
100MAP3K70.26780808

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.45160759
2alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.69396614
3Linoleic acid metabolism_Homo sapiens_hsa005912.59951504
4Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.50760082
5Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.35787467
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.21757418
7Maturity onset diabetes of the young_Homo sapiens_hsa049502.18909888
8ABC transporters_Homo sapiens_hsa020102.16295595
9Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.08696212
10Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.04170542
11Homologous recombination_Homo sapiens_hsa034402.01836107
12Caffeine metabolism_Homo sapiens_hsa002321.99233697
13Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.92942575
14Phototransduction_Homo sapiens_hsa047441.90786988
15Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.89933635
16Asthma_Homo sapiens_hsa053101.82279549
17Tryptophan metabolism_Homo sapiens_hsa003801.79860540
18Fanconi anemia pathway_Homo sapiens_hsa034601.72518610
19Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.71704805
20Primary immunodeficiency_Homo sapiens_hsa053401.66892569
21Ether lipid metabolism_Homo sapiens_hsa005651.59880140
22Nitrogen metabolism_Homo sapiens_hsa009101.58404594
23Basal transcription factors_Homo sapiens_hsa030221.56657947
24Butanoate metabolism_Homo sapiens_hsa006501.55701935
25Selenocompound metabolism_Homo sapiens_hsa004501.45921231
26Chemical carcinogenesis_Homo sapiens_hsa052041.40780626
27RNA polymerase_Homo sapiens_hsa030201.38950409
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.37363914
29Olfactory transduction_Homo sapiens_hsa047401.36411107
30Regulation of autophagy_Homo sapiens_hsa041401.31614555
31Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.31237044
32Oxidative phosphorylation_Homo sapiens_hsa001901.27668996
33Allograft rejection_Homo sapiens_hsa053301.23131831
34Arachidonic acid metabolism_Homo sapiens_hsa005901.20075883
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.20002591
36Type I diabetes mellitus_Homo sapiens_hsa049401.12632161
37Sulfur relay system_Homo sapiens_hsa041221.11040695
38Steroid hormone biosynthesis_Homo sapiens_hsa001401.10161330
39Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.06073570
40Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.04968353
41Retinol metabolism_Homo sapiens_hsa008301.04920951
42Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.01208029
43Taste transduction_Homo sapiens_hsa047421.00354274
44RNA degradation_Homo sapiens_hsa030180.98622014
45Graft-versus-host disease_Homo sapiens_hsa053320.97604626
46Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.97013963
47Glycosaminoglycan degradation_Homo sapiens_hsa005310.95693531
48Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.94466399
49Autoimmune thyroid disease_Homo sapiens_hsa053200.93841832
50Peroxisome_Homo sapiens_hsa041460.92802610
51Nicotine addiction_Homo sapiens_hsa050330.91273877
52Primary bile acid biosynthesis_Homo sapiens_hsa001200.90046678
53NOD-like receptor signaling pathway_Homo sapiens_hsa046210.89309006
54Cyanoamino acid metabolism_Homo sapiens_hsa004600.88423278
55Histidine metabolism_Homo sapiens_hsa003400.83661193
56Rheumatoid arthritis_Homo sapiens_hsa053230.82060429
57Morphine addiction_Homo sapiens_hsa050320.81301987
58Glycerolipid metabolism_Homo sapiens_hsa005610.77228504
59Vitamin digestion and absorption_Homo sapiens_hsa049770.75217701
60Fat digestion and absorption_Homo sapiens_hsa049750.73358152
61Parkinsons disease_Homo sapiens_hsa050120.72855885
62Sphingolipid metabolism_Homo sapiens_hsa006000.71879845
63RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.70839052
64Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.69496245
65Collecting duct acid secretion_Homo sapiens_hsa049660.69473148
66Ovarian steroidogenesis_Homo sapiens_hsa049130.68704487
67Dorso-ventral axis formation_Homo sapiens_hsa043200.66507596
68Serotonergic synapse_Homo sapiens_hsa047260.65199168
69Fatty acid degradation_Homo sapiens_hsa000710.61503139
70Lysosome_Homo sapiens_hsa041420.61182525
71Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.60568254
72Drug metabolism - other enzymes_Homo sapiens_hsa009830.59869718
73Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.59558276
74Staphylococcus aureus infection_Homo sapiens_hsa051500.58574224
75Lysine degradation_Homo sapiens_hsa003100.58535443
76Glycerophospholipid metabolism_Homo sapiens_hsa005640.57160088
77Purine metabolism_Homo sapiens_hsa002300.56806871
78Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.54266005
79Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.54109156
80Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.51610675
81Metabolic pathways_Homo sapiens_hsa011000.50600178
82Type II diabetes mellitus_Homo sapiens_hsa049300.48380516
83Insulin secretion_Homo sapiens_hsa049110.46556601
84Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.45747532
85Other glycan degradation_Homo sapiens_hsa005110.45309322
86One carbon pool by folate_Homo sapiens_hsa006700.44655032
87Calcium signaling pathway_Homo sapiens_hsa040200.44225922
88Mineral absorption_Homo sapiens_hsa049780.42166796
89Pyrimidine metabolism_Homo sapiens_hsa002400.41828032
90Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.40786681
91Base excision repair_Homo sapiens_hsa034100.38948913
92NF-kappa B signaling pathway_Homo sapiens_hsa040640.38818724
93beta-Alanine metabolism_Homo sapiens_hsa004100.37130007
94Vascular smooth muscle contraction_Homo sapiens_hsa042700.36870206
95Antigen processing and presentation_Homo sapiens_hsa046120.36464753
96Hematopoietic cell lineage_Homo sapiens_hsa046400.34697251
97Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.33971064
98Jak-STAT signaling pathway_Homo sapiens_hsa046300.31981720
99Glutamatergic synapse_Homo sapiens_hsa047240.31617874
100SNARE interactions in vesicular transport_Homo sapiens_hsa041300.30674356

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »