TENM1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the tenascin family and teneurin subfamily. It is expressed in the neurons and may function as a cellular signal transducer. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vocalization behavior (GO:0071625)5.78230814
2positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.55339279
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.52772935
4locomotory exploration behavior (GO:0035641)5.51629459
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.44801405
6ionotropic glutamate receptor signaling pathway (GO:0035235)5.26969072
7neuron cell-cell adhesion (GO:0007158)5.15269744
8regulation of glutamate receptor signaling pathway (GO:1900449)4.95304869
9glutamate receptor signaling pathway (GO:0007215)4.93535694
10protein localization to synapse (GO:0035418)4.82645276
11synaptic vesicle maturation (GO:0016188)4.72559265
12positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.71173081
13exploration behavior (GO:0035640)4.58413887
14synaptic transmission, glutamatergic (GO:0035249)4.51279604
15G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.49146848
16synaptic vesicle exocytosis (GO:0016079)4.39473280
17regulation of synaptic vesicle exocytosis (GO:2000300)4.39264792
18regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.32264476
19layer formation in cerebral cortex (GO:0021819)4.28390624
20glutamate secretion (GO:0014047)4.23501452
21synaptic vesicle docking involved in exocytosis (GO:0016081)4.23403082
22postsynaptic membrane organization (GO:0001941)4.21731391
23neuron-neuron synaptic transmission (GO:0007270)4.21054610
24neurotransmitter-gated ion channel clustering (GO:0072578)4.19534866
25gamma-aminobutyric acid transport (GO:0015812)4.16118642
26proline transport (GO:0015824)4.15897892
27dendritic spine morphogenesis (GO:0060997)4.05904255
28gamma-aminobutyric acid signaling pathway (GO:0007214)4.04409518
29neuron recognition (GO:0008038)3.93064837
30regulation of long-term neuronal synaptic plasticity (GO:0048169)3.92767685
31neurotransmitter secretion (GO:0007269)3.91328554
32regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.89409738
33long-term memory (GO:0007616)3.89223168
34neuronal action potential propagation (GO:0019227)3.88646252
35regulation of synaptic vesicle transport (GO:1902803)3.85739538
36positive regulation of synapse maturation (GO:0090129)3.82114195
37nucleobase catabolic process (GO:0046113)3.80562716
38cerebellar granule cell differentiation (GO:0021707)3.77944236
39regulation of excitatory postsynaptic membrane potential (GO:0060079)3.71045264
40presynaptic membrane assembly (GO:0097105)3.70892769
41negative regulation of synaptic transmission, GABAergic (GO:0032229)3.68889294
42positive regulation of membrane potential (GO:0045838)3.67738971
43regulation of synapse structural plasticity (GO:0051823)3.66870599
44dendrite morphogenesis (GO:0048813)3.66171879
45response to pheromone (GO:0019236)3.64795505
46central nervous system projection neuron axonogenesis (GO:0021952)3.63269831
47transmission of nerve impulse (GO:0019226)3.63194444
48axonal fasciculation (GO:0007413)3.62802692
49regulation of neuronal synaptic plasticity (GO:0048168)3.61104935
50regulation of postsynaptic membrane potential (GO:0060078)3.60502733
51response to histamine (GO:0034776)3.59604015
52membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.55154227
53cerebellar Purkinje cell differentiation (GO:0021702)3.53765490
54regulation of synaptic transmission, glutamatergic (GO:0051966)3.52577680
55negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.50059408
56positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.48778698
57cellular potassium ion homeostasis (GO:0030007)3.47799523
58regulation of ARF protein signal transduction (GO:0032012)3.39954538
59presynaptic membrane organization (GO:0097090)3.36583534
60synaptic vesicle endocytosis (GO:0048488)3.34776891
61synapse assembly (GO:0007416)3.33429480
62positive regulation of neurotransmitter secretion (GO:0001956)3.30357410
63neurotransmitter transport (GO:0006836)3.29616871
64regulation of synapse maturation (GO:0090128)3.27981041
65response to auditory stimulus (GO:0010996)3.27138074
66auditory behavior (GO:0031223)3.26901876
67positive regulation of synaptic transmission, GABAergic (GO:0032230)3.26781831
68pyrimidine nucleobase catabolic process (GO:0006208)3.24221738
69regulation of neurotransmitter secretion (GO:0046928)3.20667141
70membrane depolarization during action potential (GO:0086010)3.17801797
71startle response (GO:0001964)3.16733664
72behavioral fear response (GO:0001662)3.15575572
73behavioral defense response (GO:0002209)3.15575572
74regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.14122843
75membrane depolarization (GO:0051899)3.13587234
76glycine transport (GO:0015816)3.11040556
77establishment of mitochondrion localization (GO:0051654)3.10489130
78membrane hyperpolarization (GO:0060081)3.09188323
79regulation of dendritic spine morphogenesis (GO:0061001)3.05545321
80positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.05517443
81learning (GO:0007612)3.04518453
82innervation (GO:0060384)3.04493046
83regulation of synaptic plasticity (GO:0048167)3.03640491
84cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.02253770
85positive regulation of synapse assembly (GO:0051965)3.02006021
86regulation of neurotransmitter levels (GO:0001505)3.01270390
87positive regulation of action potential (GO:0045760)3.00933045
88cochlea development (GO:0090102)2.98320555
89positive regulation of neurotransmitter transport (GO:0051590)2.97654206
90positive regulation of dendritic spine development (GO:0060999)2.96239922
91cell migration in hindbrain (GO:0021535)2.95736249
92fear response (GO:0042596)2.95516364
93positive regulation of dendritic spine morphogenesis (GO:0061003)2.94754061
94dendritic spine organization (GO:0097061)2.94638775
95social behavior (GO:0035176)2.94035204
96intraspecies interaction between organisms (GO:0051703)2.94035204
97mechanosensory behavior (GO:0007638)2.93593958
98regulation of neurotransmitter transport (GO:0051588)2.92768538
99organelle transport along microtubule (GO:0072384)2.92760565
100vesicle transport along microtubule (GO:0047496)2.92361592
101regulation of synaptic transmission, GABAergic (GO:0032228)2.89165853
102synapse organization (GO:0050808)2.88980534
103long-term synaptic potentiation (GO:0060291)2.88854931
104cell differentiation in hindbrain (GO:0021533)2.88680124
105negative regulation of neurotransmitter transport (GO:0051589)2.88206878
106cell communication by electrical coupling (GO:0010644)2.87259552
107cAMP catabolic process (GO:0006198)2.87018618
108neuronal ion channel clustering (GO:0045161)2.84364907
109regulation of vesicle fusion (GO:0031338)2.83983579
110regulation of voltage-gated calcium channel activity (GO:1901385)2.82045417
111establishment of nucleus localization (GO:0040023)2.78521569
112negative regulation of neurotransmitter secretion (GO:0046929)2.77332652
113regulation of respiratory system process (GO:0044065)2.75101268
114urinary tract smooth muscle contraction (GO:0014848)2.72956327
115regulation of respiratory gaseous exchange (GO:0043576)2.71389912
116cellular sodium ion homeostasis (GO:0006883)2.71225462
117mitochondrion transport along microtubule (GO:0047497)2.70964695
118establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.70964695
119cyclic nucleotide catabolic process (GO:0009214)2.69608508
120phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.68923216
121neuronal action potential (GO:0019228)2.68899378
122central nervous system neuron axonogenesis (GO:0021955)2.68533913
123adult walking behavior (GO:0007628)2.66803354
124dopamine biosynthetic process (GO:0042416)2.65590540
125central nervous system myelination (GO:0022010)2.64882517
126axon ensheathment in central nervous system (GO:0032291)2.64882517
127serotonin metabolic process (GO:0042428)2.64580172

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.88848289
2GBX2_23144817_ChIP-Seq_PC3_Human3.97451548
3JARID2_20064375_ChIP-Seq_MESCs_Mouse2.98792248
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.90628067
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.87373284
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.52537803
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.52537803
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.50288279
9REST_21632747_ChIP-Seq_MESCs_Mouse2.46330920
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.45767558
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.44089810
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.42437362
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.35186490
14EED_16625203_ChIP-ChIP_MESCs_Mouse2.32796951
15DROSHA_22980978_ChIP-Seq_HELA_Human2.28962230
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.27370113
17ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.26474732
18MTF2_20144788_ChIP-Seq_MESCs_Mouse2.26314267
19SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.22540955
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.11828344
21RNF2_27304074_Chip-Seq_ESCs_Mouse2.09251339
22RBPJ_22232070_ChIP-Seq_NCS_Mouse2.05239648
23SUZ12_27294783_Chip-Seq_ESCs_Mouse2.04171665
24CTBP2_25329375_ChIP-Seq_LNCAP_Human1.93083727
25ZFP57_27257070_Chip-Seq_ESCs_Mouse1.92119051
26IKZF1_21737484_ChIP-ChIP_HCT116_Human1.90801246
27CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.89919664
28AR_21572438_ChIP-Seq_LNCaP_Human1.89630931
29SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.87623730
30TAF15_26573619_Chip-Seq_HEK293_Human1.87307443
31REST_18959480_ChIP-ChIP_MESCs_Mouse1.78550444
32SMAD4_21799915_ChIP-Seq_A2780_Human1.77493587
33PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.75370897
34CTBP1_25329375_ChIP-Seq_LNCAP_Human1.75248541
35RARB_27405468_Chip-Seq_BRAIN_Mouse1.74107242
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.70832886
37P300_19829295_ChIP-Seq_ESCs_Human1.64520369
38NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.59017876
39IGF1R_20145208_ChIP-Seq_DFB_Human1.58167497
40CBX2_27304074_Chip-Seq_ESCs_Mouse1.54586570
41BMI1_23680149_ChIP-Seq_NPCS_Mouse1.48908252
42ZNF274_21170338_ChIP-Seq_K562_Hela1.48252520
43SMAD3_21741376_ChIP-Seq_EPCs_Human1.46689092
44POU3F2_20337985_ChIP-ChIP_501MEL_Human1.45213777
45SMAD_19615063_ChIP-ChIP_OVARY_Human1.44202127
46VDR_22108803_ChIP-Seq_LS180_Human1.43324589
47RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.42998088
48PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.42058865
49EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.41632555
50SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40216867
51STAT3_23295773_ChIP-Seq_U87_Human1.39329116
52AR_25329375_ChIP-Seq_VCAP_Human1.38672897
53PIAS1_25552417_ChIP-Seq_VCAP_Human1.37817651
54MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.31687678
55TOP2B_26459242_ChIP-Seq_MCF-7_Human1.31098280
56RNF2_27304074_Chip-Seq_NSC_Mouse1.30919304
57SOX2_21211035_ChIP-Seq_LN229_Gbm1.29914530
58TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29443995
59CDX2_19796622_ChIP-Seq_MESCs_Mouse1.28972858
60BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.25308839
61AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.24839380
62CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.24821164
63MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.24410625
64OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23947013
65NR3C1_23031785_ChIP-Seq_PC12_Mouse1.22920903
66TCF4_23295773_ChIP-Seq_U87_Human1.22426546
67RING1B_27294783_Chip-Seq_ESCs_Mouse1.21682177
68FUS_26573619_Chip-Seq_HEK293_Human1.21145340
69ZNF217_24962896_ChIP-Seq_MCF-7_Human1.20635928
70AR_19668381_ChIP-Seq_PC3_Human1.20183327
71ARNT_22903824_ChIP-Seq_MCF-7_Human1.19920143
72TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.19535883
73TP53_16413492_ChIP-PET_HCT116_Human1.18929204
74SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18687858
75POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.17633467
76TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17633467
77CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15784389
78ER_23166858_ChIP-Seq_MCF-7_Human1.15375991
79RUNX2_22187159_ChIP-Seq_PCA_Human1.14933166
80TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.14746810
81P53_22127205_ChIP-Seq_FIBROBLAST_Human1.14553653
82NANOG_18555785_Chip-Seq_ESCs_Mouse1.14117893
83YAP1_20516196_ChIP-Seq_MESCs_Mouse1.12524745
84ERG_21242973_ChIP-ChIP_JURKAT_Human1.11652724
85CTNNB1_20460455_ChIP-Seq_HCT116_Human1.10503483
86RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.10499218
87NR3C1_21868756_ChIP-Seq_MCF10A_Human1.10377059
88AHR_22903824_ChIP-Seq_MCF-7_Human1.09800525
89RING1B_27294783_Chip-Seq_NPCs_Mouse1.07351494
90FLI1_21867929_ChIP-Seq_TH2_Mouse1.06100903
91LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05741065
92UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.04678826
93VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.04668677
94BCAT_22108803_ChIP-Seq_LS180_Human1.04082609
95E2F1_18555785_Chip-Seq_ESCs_Mouse1.03058223
96TP53_18474530_ChIP-ChIP_U2OS_Human1.02828902
97RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.02152445
98MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01769853
99PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.00568924
100WT1_25993318_ChIP-Seq_PODOCYTE_Human1.00466662
101TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.00364075
102KDM2B_26808549_Chip-Seq_REH_Human0.99851294
103RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99768056
104STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.99631358
105JUN_21703547_ChIP-Seq_K562_Human0.97919172
106PRDM14_20953172_ChIP-Seq_ESCs_Human0.97099867
107TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.96908363
108CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.96629031
109SMAD4_21741376_ChIP-Seq_HESCs_Human0.96581934
110TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95376930
111EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.95134829
112RXR_22108803_ChIP-Seq_LS180_Human0.95058553
113SUZ12_27294783_Chip-Seq_NPCs_Mouse0.94997436
114SMAD3_21741376_ChIP-Seq_ESCs_Human0.94967640

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.77952549
2MP0003880_abnormal_central_pattern4.26720316
3MP0003635_abnormal_synaptic_transmissio3.96244268
4MP0009046_muscle_twitch3.42910025
5MP0005423_abnormal_somatic_nervous3.38144280
6MP0009745_abnormal_behavioral_response3.35987546
7MP0004270_analgesia3.33005176
8MP0002063_abnormal_learning/memory/cond3.16342631
9MP0001968_abnormal_touch/_nociception3.06232831
10MP0002064_seizures2.97482333
11MP0002572_abnormal_emotion/affect_behav2.89294830
12MP0002734_abnormal_mechanical_nocicepti2.75711541
13MP0002735_abnormal_chemical_nociception2.71709731
14MP0001486_abnormal_startle_reflex2.70454568
15MP0001440_abnormal_grooming_behavior2.51599995
16MP0002272_abnormal_nervous_system2.51551659
17MP0001501_abnormal_sleep_pattern2.37596671
18MP0002736_abnormal_nociception_after2.32442349
19MP0005645_abnormal_hypothalamus_physiol2.30827225
20MP0002184_abnormal_innervation2.25693258
21MP0002067_abnormal_sensory_capabilities2.14929820
22MP0000778_abnormal_nervous_system2.13793802
23MP0006276_abnormal_autonomic_nervous2.06941741
24MP0002733_abnormal_thermal_nociception2.05506469
25MP0002557_abnormal_social/conspecific_i2.03985967
26MP0001970_abnormal_pain_threshold1.96736515
27MP0003879_abnormal_hair_cell1.95573328
28MP0004924_abnormal_behavior1.91629584
29MP0005386_behavior/neurological_phenoty1.91629584
30MP0008569_lethality_at_weaning1.81825945
31MP0001188_hyperpigmentation1.68946972
32MP0005646_abnormal_pituitary_gland1.66399194
33MP0003787_abnormal_imprinting1.63939285
34MP0000569_abnormal_digit_pigmentation1.60402883
35MP0009780_abnormal_chondrocyte_physiolo1.59611111
36MP0004811_abnormal_neuron_physiology1.58709411
37MP0004858_abnormal_nervous_system1.54722569
38MP0000955_abnormal_spinal_cord1.50054961
39MP0003121_genomic_imprinting1.49341839
40MP0004742_abnormal_vestibular_system1.48854224
41MP0004043_abnormal_pH_regulation1.47937002
42MP0004142_abnormal_muscle_tone1.45473766
43MP0004885_abnormal_endolymph1.44280970
44MP0002066_abnormal_motor_capabilities/c1.41088287
45MP0001984_abnormal_olfaction1.38509459
46MP0002882_abnormal_neuron_morphology1.38013700
47MP0003890_abnormal_embryonic-extraembry1.33013102
48MP0008877_abnormal_DNA_methylation1.31393538
49MP0003329_amyloid_beta_deposits1.30419787
50MP0002909_abnormal_adrenal_gland1.29978621
51MP0001529_abnormal_vocalization1.27859287
52MP0002822_catalepsy1.25529769
53MP0001502_abnormal_circadian_rhythm1.22760239
54MP0002009_preneoplasia1.21824484
55MP0004145_abnormal_muscle_electrophysio1.17419304
56MP0003122_maternal_imprinting1.17310218
57MP0003633_abnormal_nervous_system1.15896274
58MP0004130_abnormal_muscle_cell1.13399396
59MP0002152_abnormal_brain_morphology1.11969733
60MP0003136_yellow_coat_color1.06492761
61MP0001905_abnormal_dopamine_level1.04248687
62MP0006292_abnormal_olfactory_placode1.03235062
63MP0003631_nervous_system_phenotype1.02969074
64MP0005187_abnormal_penis_morphology1.02831422
65MP0002102_abnormal_ear_morphology0.97616347
66MP0001963_abnormal_hearing_physiology0.96558998
67MP0000631_abnormal_neuroendocrine_gland0.95166902
68MP0002653_abnormal_ependyma_morphology0.92883964
69MP0002069_abnormal_eating/drinking_beha0.90589135
70MP0004085_abnormal_heartbeat0.89378411
71MP0005551_abnormal_eye_electrophysiolog0.89315319
72MP0002229_neurodegeneration0.88491508
73MP0001299_abnormal_eye_distance/0.87223148
74MP0001485_abnormal_pinna_reflex0.85284556
75MP0002752_abnormal_somatic_nervous0.83914215
76MP0003878_abnormal_ear_physiology0.81887781
77MP0005377_hearing/vestibular/ear_phenot0.81887781
78MP0003123_paternal_imprinting0.81769949
79MP0005409_darkened_coat_color0.80728132
80MP0008872_abnormal_physiological_respon0.80482851
81MP0010386_abnormal_urinary_bladder0.79520410
82MP0003632_abnormal_nervous_system0.79305840
83MP0005167_abnormal_blood-brain_barrier0.79084450
84MP0001177_atelectasis0.76707851
85MP0008874_decreased_physiological_sensi0.76699421
86MP0002638_abnormal_pupillary_reflex0.73644849
87MP0004510_myositis0.71674954
88MP0005394_taste/olfaction_phenotype0.70845971
89MP0005499_abnormal_olfactory_system0.70845971
90MP0004484_altered_response_of0.70342780
91MP0003137_abnormal_impulse_conducting0.69019082
92MP0001943_abnormal_respiration0.69009019
93MP0000026_abnormal_inner_ear0.68668633
94MP0003634_abnormal_glial_cell0.67900398
95MP0002234_abnormal_pharynx_morphology0.67258786
96MP0000751_myopathy0.65822149
97MP0004215_abnormal_myocardial_fiber0.65483148
98MP0003861_abnormal_nervous_system0.64808262
99MP0003045_fibrosis0.64555174
100MP0008995_early_reproductive_senescence0.63965737
101MP0001986_abnormal_taste_sensitivity0.63514592
102MP0008057_abnormal_DNA_replication0.63424374
103MP0003646_muscle_fatigue0.63203527
104MP0001664_abnormal_digestion0.62725684
105MP0005171_absent_coat_pigmentation0.61029558
106MP0005535_abnormal_body_temperature0.58779930
107MP0003690_abnormal_glial_cell0.58049476
108MP0010770_preweaning_lethality0.57835526
109MP0002082_postnatal_lethality0.57835526
110MP0010769_abnormal_survival0.57724046
111MP0000920_abnormal_myelination0.57169276
112MP0002837_dystrophic_cardiac_calcinosis0.56328637
113MP0002876_abnormal_thyroid_physiology0.55383085
114MP0008004_abnormal_stomach_pH0.55343702
115MP0003956_abnormal_body_size0.55269445
116MP0010768_mortality/aging0.54248260
117MP0003938_abnormal_ear_development0.54227003
118MP0002928_abnormal_bile_duct0.53908804
119MP0004133_heterotaxia0.52859972
120MP0002081_perinatal_lethality0.52657454
121MP0001765_abnormal_ion_homeostasis0.52397143
122MP0005174_abnormal_tail_pigmentation0.52032003
123MP0005448_abnormal_energy_balance0.50316042

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.27439046
2Focal seizures (HP:0007359)5.56702330
3Myokymia (HP:0002411)4.95871567
4Febrile seizures (HP:0002373)4.94045005
5Visual hallucinations (HP:0002367)4.92201141
6Progressive cerebellar ataxia (HP:0002073)4.84465919
7Epileptic encephalopathy (HP:0200134)4.78870159
8Atonic seizures (HP:0010819)4.33994509
9Broad-based gait (HP:0002136)4.14310322
10Absence seizures (HP:0002121)4.09664994
11Action tremor (HP:0002345)3.93153516
12Mutism (HP:0002300)3.75282395
13Dialeptic seizures (HP:0011146)3.71718974
14Generalized tonic-clonic seizures (HP:0002069)3.69835335
15Hyperventilation (HP:0002883)3.58166660
16Gaze-evoked nystagmus (HP:0000640)3.54772589
17Drooling (HP:0002307)3.28688330
18Excessive salivation (HP:0003781)3.28688330
19Genetic anticipation (HP:0003743)3.28633068
20Poor eye contact (HP:0000817)3.28089404
21Diplopia (HP:0000651)3.14468043
22Abnormality of binocular vision (HP:0011514)3.14468043
23Supranuclear gaze palsy (HP:0000605)3.09077573
24Truncal ataxia (HP:0002078)2.98948136
25Dysdiadochokinesis (HP:0002075)2.96832034
26Limb dystonia (HP:0002451)2.87830718
27Fetal akinesia sequence (HP:0001989)2.83976011
28Impaired social interactions (HP:0000735)2.83144136
29Abnormal social behavior (HP:0012433)2.83144136
30Absent speech (HP:0001344)2.79289612
31Abnormality of the corticospinal tract (HP:0002492)2.78163653
32Dynein arm defect of respiratory motile cilia (HP:0012255)2.77917489
33Absent/shortened dynein arms (HP:0200106)2.77917489
34Urinary bladder sphincter dysfunction (HP:0002839)2.71738136
35Dysmetria (HP:0001310)2.70253486
36Abnormal eating behavior (HP:0100738)2.69891252
37Polyphagia (HP:0002591)2.68786362
38Papilledema (HP:0001085)2.66728930
39Amyotrophic lateral sclerosis (HP:0007354)2.64589198
40Inappropriate behavior (HP:0000719)2.62988788
41Thyroid-stimulating hormone excess (HP:0002925)2.62256808
42Hemiparesis (HP:0001269)2.61221269
43Ankle clonus (HP:0011448)2.60282664
44Impaired smooth pursuit (HP:0007772)2.53315085
45Progressive inability to walk (HP:0002505)2.51415157
46Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.50094605
47Degeneration of the lateral corticospinal tracts (HP:0002314)2.50094605
48Scanning speech (HP:0002168)2.45064974
49Impaired vibration sensation in the lower limbs (HP:0002166)2.44825601
50Agitation (HP:0000713)2.43903872
51Epileptiform EEG discharges (HP:0011182)2.43901346
52Akinesia (HP:0002304)2.42459133
53Neurofibrillary tangles (HP:0002185)2.38675599
54Postural instability (HP:0002172)2.35378425
55EEG with generalized epileptiform discharges (HP:0011198)2.33264028
56Overgrowth (HP:0001548)2.33072379
57Truncal obesity (HP:0001956)2.31399512
58Protruding tongue (HP:0010808)2.31134206
59Abnormality of ocular smooth pursuit (HP:0000617)2.30344062
60Depression (HP:0000716)2.29950343
61Inability to walk (HP:0002540)2.29825813
62Cerebral inclusion bodies (HP:0100314)2.28816973
63Fair hair (HP:0002286)2.27628226
64Anxiety (HP:0000739)2.26957301
65Hemiplegia (HP:0002301)2.25929999
66Aqueductal stenosis (HP:0002410)2.25763999
67Pheochromocytoma (HP:0002666)2.24810655
68Stereotypic behavior (HP:0000733)2.21902665
69Absent eyebrow (HP:0002223)2.21634914
70Macroorchidism (HP:0000053)2.21125186
71Abnormality of salivation (HP:0100755)2.19745024
72Blue irides (HP:0000635)2.17684320
73Hypsarrhythmia (HP:0002521)2.17405881
74Status epilepticus (HP:0002133)2.16882578
75Abnormal hair whorl (HP:0010721)2.15549820
76Hyperthyroidism (HP:0000836)2.15151892
77Obstructive sleep apnea (HP:0002870)2.12861019
78Intention tremor (HP:0002080)2.12211939
79Abnormal ciliary motility (HP:0012262)2.11640682
80Widely spaced teeth (HP:0000687)2.10440403
81Amblyopia (HP:0000646)2.09658658
82Hypoplastic nipples (HP:0002557)2.09212274
83Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.09116495
84Sporadic (HP:0003745)2.07351922
85Spastic gait (HP:0002064)2.03912299
86Urinary urgency (HP:0000012)2.02678363
87Shawl scrotum (HP:0000049)2.00683184
88Neoplasm of the heart (HP:0100544)1.97979320
89Insidious onset (HP:0003587)1.94887526
90Termporal pattern (HP:0011008)1.94887526
91Dysmetric saccades (HP:0000641)1.94666662
92Exotropia (HP:0000577)1.94288152
93Generalized myoclonic seizures (HP:0002123)1.94270748
94Gait imbalance (HP:0002141)1.92399847
95Bradykinesia (HP:0002067)1.92207227
96Parakeratosis (HP:0001036)1.89739910
97Morphological abnormality of the pyramidal tract (HP:0002062)1.89160148
98Generalized hypopigmentation of hair (HP:0011358)1.87613465
99Spastic tetraplegia (HP:0002510)1.87379341
100Torticollis (HP:0000473)1.85099216
101Tented upper lip vermilion (HP:0010804)1.84037093
102Hypoplasia of the corpus callosum (HP:0002079)1.82702175
103Split foot (HP:0001839)1.82667555
104Impaired vibratory sensation (HP:0002495)1.81930981
105Intellectual disability, severe (HP:0010864)1.80236033
106Lower limb muscle weakness (HP:0007340)1.79937804
107Abnormality of the lower motor neuron (HP:0002366)1.78882341
108Bradycardia (HP:0001662)1.78813318
109Syncope (HP:0001279)1.78343807
110Neuroendocrine neoplasm (HP:0100634)1.78118344
111Neuronal loss in central nervous system (HP:0002529)1.77944139
112Hypothermia (HP:0002045)1.77389057
113Unilateral renal agenesis (HP:0000122)1.76365784
114Volvulus (HP:0002580)1.75982340
115Hepatoblastoma (HP:0002884)1.75474633
116Lower limb amyotrophy (HP:0007210)1.75312541
117Gastroesophageal reflux (HP:0002020)1.75008306
118Abnormal EKG (HP:0003115)1.74567536
119Autism (HP:0000717)1.72518086
120Incomplete penetrance (HP:0003829)1.69594179
121Megalencephaly (HP:0001355)1.68085333
122Horizontal nystagmus (HP:0000666)1.67776846
123Prolonged QT interval (HP:0001657)1.67206000
124Sleep apnea (HP:0010535)1.65043103
125Gait ataxia (HP:0002066)1.64858114
126Lissencephaly (HP:0001339)1.62997700
127Abnormality of saccadic eye movements (HP:0000570)1.62484723
128Bronchomalacia (HP:0002780)1.62020160
129Cubitus valgus (HP:0002967)1.61441956
130Focal dystonia (HP:0004373)1.60736072
131Abnormal respiratory epithelium morphology (HP:0012253)1.60667710

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.27606728
2NTRK34.56087164
3MAP3K93.21167520
4MAP3K43.14195569
5CASK2.86062711
6MAP2K72.85311006
7EPHA42.79202645
8NTRK22.70957533
9SIK22.59710389
10MINK12.34112540
11TNIK2.28118692
12MAPK132.19197684
13SIK32.14144689
14EPHA32.01812586
15TAOK31.95022119
16MAP2K41.92693726
17PAK61.66719250
18MAP3K121.63334276
19RIPK41.61542341
20DAPK21.59269518
21LATS21.57400168
22PRPF4B1.54012258
23PLK21.44884214
24PHKG11.40874353
25PHKG21.40874353
26CAMKK21.36931854
27STK381.34129876
28CAMKK11.30908407
29CDK51.30487547
30PNCK1.26043074
31NTRK11.25343416
32EEF2K1.25029039
33MARK21.22899444
34WNK41.22322097
35KSR11.18995106
36FRK1.17998547
37PRKCG1.13985291
38GRK51.13657549
39PINK11.08521959
40STK391.04995570
41CAMK2A1.03468058
42CAMK11.02590664
43CAMK1G1.01148866
44BRD40.98698438
45CSNK1G20.98282350
46SGK20.95351596
47BCR0.89877214
48ERBB30.89055408
49DAPK10.87712051
50DYRK20.84665284
51PKN10.84419226
52DYRK1A0.83171944
53STK110.81682838
54MAP3K60.80511823
55SGK4940.80029887
56SGK2230.80029887
57NLK0.79216170
58SGK10.76010609
59FES0.74061479
60WNK10.73935043
61UHMK10.73551402
62KSR20.72582349
63CAMK2B0.71582458
64BMPR20.71335421
65AKT30.66726276
66ERBB20.65480206
67PAK30.65051828
68SGK30.63779961
69LATS10.62810693
70PRKCE0.62633287
71CDK180.62023017
72PRKCH0.61059119
73CDK150.60487512
74MKNK20.60338480
75MAP3K130.59315592
76RET0.58929289
77CAMK40.57345355
78CDK190.56231526
79GRK70.55983972
80PRKCZ0.55950612
81WNK30.55882695
82ADRBK20.55440216
83MAPK120.54807433
84PRKD30.54693888
85PRKAA10.54516063
86CDK140.54196301
87ALK0.53415407
88MAP2K60.53247348
89CDK11A0.53183306
90RIPK10.51495035
91NEK60.51017613
92MAPKAPK50.50138562
93FYN0.49504575
94PRKG10.48863365
95TAOK10.48735221
96RPS6KA30.48069729
97CDK30.45972458
98CAMK1D0.45440693
99TYRO30.44917959
100FGR0.43846546
101PIK3CG0.43425913
102CDC42BPA0.43120070
103INSRR0.42339006
104MAPK100.41798435
105CAMK2D0.41762774
106MAP3K70.40998721
107OXSR10.40603602
108MAPK80.40543724
109MAP3K20.39013892
110DYRK1B0.38377412
111TNK20.38255361
112BMPR1B0.38191639
113DMPK0.38064935
114CAMK2G0.37901503
115SIK10.36785091
116CSNK1A1L0.36201390
117GSK3B0.35854309
118RAF10.35416893
119RPS6KA20.33245043
120CDK120.33079488
121CSNK1G30.32737873
122PRKCB0.32234730
123TAOK20.31933747
124CSNK1D0.31863840
125CSNK1E0.31640896
126PRKACA0.29134077
127JAK20.29024565
128PDK10.28181735

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.53947872
2Retrograde endocannabinoid signaling_Homo sapiens_hsa047233.00157970
3Synaptic vesicle cycle_Homo sapiens_hsa047212.80251616
4GABAergic synapse_Homo sapiens_hsa047272.79274088
5Glutamatergic synapse_Homo sapiens_hsa047242.75796384
6Circadian entrainment_Homo sapiens_hsa047132.71428518
7Morphine addiction_Homo sapiens_hsa050322.69269025
8Long-term potentiation_Homo sapiens_hsa047202.52819992
9Olfactory transduction_Homo sapiens_hsa047402.25301560
10Taste transduction_Homo sapiens_hsa047422.23715318
11Amphetamine addiction_Homo sapiens_hsa050312.18093693
12Salivary secretion_Homo sapiens_hsa049702.11013688
13Dopaminergic synapse_Homo sapiens_hsa047282.04964728
14Serotonergic synapse_Homo sapiens_hsa047261.95865781
15Long-term depression_Homo sapiens_hsa047301.89255520
16Cholinergic synapse_Homo sapiens_hsa047251.86272303
17Insulin secretion_Homo sapiens_hsa049111.83916754
18Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.74946483
19Calcium signaling pathway_Homo sapiens_hsa040201.71063237
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.68997020
21Gastric acid secretion_Homo sapiens_hsa049711.66836667
22Renin secretion_Homo sapiens_hsa049241.65079729
23Cocaine addiction_Homo sapiens_hsa050301.57711515
24Axon guidance_Homo sapiens_hsa043601.56412148
25Oxytocin signaling pathway_Homo sapiens_hsa049211.55324997
26Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.52051734
27Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.48604631
28Type II diabetes mellitus_Homo sapiens_hsa049301.44982922
29Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.33434304
30cAMP signaling pathway_Homo sapiens_hsa040241.32345388
31GnRH signaling pathway_Homo sapiens_hsa049121.31000333
32Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.26608611
33Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.21451295
34Gap junction_Homo sapiens_hsa045401.20167251
35Phosphatidylinositol signaling system_Homo sapiens_hsa040701.15560950
36Estrogen signaling pathway_Homo sapiens_hsa049151.14686360
37ErbB signaling pathway_Homo sapiens_hsa040121.11499767
38Collecting duct acid secretion_Homo sapiens_hsa049661.10812351
39Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.99647797
40cGMP-PKG signaling pathway_Homo sapiens_hsa040220.98733695
41Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.98474523
42Glioma_Homo sapiens_hsa052140.92778137
43Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.92255607
44Melanogenesis_Homo sapiens_hsa049160.91723701
45Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.89497691
46Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.89279955
47ABC transporters_Homo sapiens_hsa020100.88365206
48Pancreatic secretion_Homo sapiens_hsa049720.85278694
49Vascular smooth muscle contraction_Homo sapiens_hsa042700.84432785
50Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.82763044
51Phototransduction_Homo sapiens_hsa047440.81852157
52Phospholipase D signaling pathway_Homo sapiens_hsa040720.81216058
53Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.80417355
54Dorso-ventral axis formation_Homo sapiens_hsa043200.79950314
55Cardiac muscle contraction_Homo sapiens_hsa042600.79372706
56Choline metabolism in cancer_Homo sapiens_hsa052310.79174201
57MAPK signaling pathway_Homo sapiens_hsa040100.76386544
58Dilated cardiomyopathy_Homo sapiens_hsa054140.76142431
59Butanoate metabolism_Homo sapiens_hsa006500.74603677
60FoxO signaling pathway_Homo sapiens_hsa040680.73927801
61Non-small cell lung cancer_Homo sapiens_hsa052230.73198187
62Fatty acid biosynthesis_Homo sapiens_hsa000610.72124507
63Ras signaling pathway_Homo sapiens_hsa040140.70779956
64Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.70532982
65Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.70324349
66Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.67219193
67Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.67062531
68Thyroid hormone synthesis_Homo sapiens_hsa049180.66874476
69Carbohydrate digestion and absorption_Homo sapiens_hsa049730.63213642
70AMPK signaling pathway_Homo sapiens_hsa041520.61850864
71Oocyte meiosis_Homo sapiens_hsa041140.61521361
72T cell receptor signaling pathway_Homo sapiens_hsa046600.61280283
73Prion diseases_Homo sapiens_hsa050200.58594133
74Ovarian steroidogenesis_Homo sapiens_hsa049130.56805003
75Rap1 signaling pathway_Homo sapiens_hsa040150.56606079
76Wnt signaling pathway_Homo sapiens_hsa043100.56157008
77Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.56108098
78Renal cell carcinoma_Homo sapiens_hsa052110.56070895
79Prostate cancer_Homo sapiens_hsa052150.54169123
80Circadian rhythm_Homo sapiens_hsa047100.53756336
81Sphingolipid signaling pathway_Homo sapiens_hsa040710.53234675
82Endometrial cancer_Homo sapiens_hsa052130.53017476
83Lysine degradation_Homo sapiens_hsa003100.52543816
84Neurotrophin signaling pathway_Homo sapiens_hsa047220.50960441
85Linoleic acid metabolism_Homo sapiens_hsa005910.49397827
86Vibrio cholerae infection_Homo sapiens_hsa051100.49276158
87Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.48862666
88Inositol phosphate metabolism_Homo sapiens_hsa005620.48059053
89Alcoholism_Homo sapiens_hsa050340.46390082
90Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.45206816
91Histidine metabolism_Homo sapiens_hsa003400.41538954
92Mineral absorption_Homo sapiens_hsa049780.41358755
93Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.41334487
94Type I diabetes mellitus_Homo sapiens_hsa049400.41268366
95African trypanosomiasis_Homo sapiens_hsa051430.41235318
96Colorectal cancer_Homo sapiens_hsa052100.41156462
97Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41100146
98Thyroid hormone signaling pathway_Homo sapiens_hsa049190.40722951
99Melanoma_Homo sapiens_hsa052180.40680146
100VEGF signaling pathway_Homo sapiens_hsa043700.40524390
101Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.40353667
102mTOR signaling pathway_Homo sapiens_hsa041500.39293289
103Chemokine signaling pathway_Homo sapiens_hsa040620.39248203
104Glucagon signaling pathway_Homo sapiens_hsa049220.37501468
105Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.36002934
106Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.35734995
107Pancreatic cancer_Homo sapiens_hsa052120.34172011
108Prolactin signaling pathway_Homo sapiens_hsa049170.32455993
109Acute myeloid leukemia_Homo sapiens_hsa052210.32313254
110Bile secretion_Homo sapiens_hsa049760.31938892
111Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.30503019
112Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.30249009
113Insulin signaling pathway_Homo sapiens_hsa049100.30242046
114Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.30014055
115Chronic myeloid leukemia_Homo sapiens_hsa052200.29432101
116SNARE interactions in vesicular transport_Homo sapiens_hsa041300.28861221
117Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.28133551

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