TENM3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a large transmembrane protein that may be involved in the regulation of neuronal development. Mutation in this gene causes microphthalmia. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1paraxial mesoderm development (GO:0048339)5.08498741
2layer formation in cerebral cortex (GO:0021819)4.44214426
3locomotory exploration behavior (GO:0035641)4.22491165
4axonal fasciculation (GO:0007413)4.06821384
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.97943789
6synaptic vesicle maturation (GO:0016188)3.95806363
7regulation of short-term neuronal synaptic plasticity (GO:0048172)3.83725995
8dendritic spine morphogenesis (GO:0060997)3.76098673
9cell migration in hindbrain (GO:0021535)3.71269257
10innervation (GO:0060384)3.69023495
11exploration behavior (GO:0035640)3.68981183
12central nervous system projection neuron axonogenesis (GO:0021952)3.61262345
13positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.60834680
14vocalization behavior (GO:0071625)3.60025653
15neuron recognition (GO:0008038)3.59887474
16synaptic vesicle docking involved in exocytosis (GO:0016081)3.57546377
17dendrite morphogenesis (GO:0048813)3.54295088
18regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.52447647
19neuron cell-cell adhesion (GO:0007158)3.44972723
20protein localization to synapse (GO:0035418)3.43792217
21regulation of glutamate receptor signaling pathway (GO:1900449)3.31027814
22establishment of nucleus localization (GO:0040023)3.25824412
23planar cell polarity pathway involved in neural tube closure (GO:0090179)3.23368511
24glutamate secretion (GO:0014047)3.21076071
25pyrimidine nucleobase catabolic process (GO:0006208)3.20010203
26positive regulation of synapse maturation (GO:0090129)3.18563501
27notochord development (GO:0030903)3.17992014
28establishment of planar polarity (GO:0001736)3.12370230
29establishment of tissue polarity (GO:0007164)3.12370230
30establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)3.10974376
31ganglion development (GO:0061548)3.07114382
32regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.05762904
33synaptic vesicle exocytosis (GO:0016079)3.03046163
34regulation of axon extension involved in axon guidance (GO:0048841)2.98818312
35proline transport (GO:0015824)2.97699948
36axon extension involved in axon guidance (GO:0048846)2.96490890
37neuron projection extension involved in neuron projection guidance (GO:1902284)2.96490890
38non-canonical Wnt signaling pathway (GO:0035567)2.96034578
39regulation of synaptic vesicle exocytosis (GO:2000300)2.95101463
40neurotransmitter-gated ion channel clustering (GO:0072578)2.95092864
41dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.92031704
42axon extension (GO:0048675)2.91035220
43negative regulation of catenin import into nucleus (GO:0035414)2.91018301
44regulation of synapse structural plasticity (GO:0051823)2.90884591
45presynaptic membrane organization (GO:0097090)2.87932807
46lung-associated mesenchyme development (GO:0060484)2.87904641
47collagen fibril organization (GO:0030199)2.87201969
48regulation of long-term neuronal synaptic plasticity (GO:0048169)2.86548203
49regulation of neuronal synaptic plasticity (GO:0048168)2.83935235
50regulation of axon guidance (GO:1902667)2.82928302
51body morphogenesis (GO:0010171)2.80879826
52postsynaptic membrane organization (GO:0001941)2.80207393
53central nervous system neuron axonogenesis (GO:0021955)2.80108574
54negative regulation of chondrocyte differentiation (GO:0032331)2.77002967
55neuronal stem cell maintenance (GO:0097150)2.76906311
56regulation of dendritic spine morphogenesis (GO:0061001)2.76121405
57lens fiber cell development (GO:0070307)2.76120234
58cell migration involved in sprouting angiogenesis (GO:0002042)2.75636433
59ionotropic glutamate receptor signaling pathway (GO:0035235)2.74826352
60head development (GO:0060322)2.74658058
61cell communication by electrical coupling (GO:0010644)2.71496253
62suckling behavior (GO:0001967)2.71057816
63insulin-like growth factor receptor signaling pathway (GO:0048009)2.70805585
64inner ear receptor cell development (GO:0060119)2.69709909
65cell surface receptor signaling pathway involved in heart development (GO:0061311)2.68523754
66auditory behavior (GO:0031223)2.68232198
67negative regulation of axon extension involved in axon guidance (GO:0048843)2.67144259
68lateral sprouting from an epithelium (GO:0060601)2.67002272
69neuromuscular process controlling balance (GO:0050885)2.65890010
70calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.65214873
71regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.65122160
72establishment or maintenance of bipolar cell polarity (GO:0061245)2.64865535
73establishment or maintenance of apical/basal cell polarity (GO:0035088)2.64865535
74morphogenesis of an epithelial sheet (GO:0002011)2.64796742
75neurotransmitter secretion (GO:0007269)2.64136644
76midgut development (GO:0007494)2.63826105
77hippo signaling (GO:0035329)2.63791341
78regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.63652546
79glutamate receptor signaling pathway (GO:0007215)2.63229367
80negative chemotaxis (GO:0050919)2.62967806
81positive regulation of dendritic spine morphogenesis (GO:0061003)2.62788986
82asymmetric protein localization (GO:0008105)2.60909445
83gamma-aminobutyric acid transport (GO:0015812)2.60908913
84dendritic spine organization (GO:0097061)2.59842010
85negative regulation of sodium ion transport (GO:0010766)2.58113562
86synaptic transmission, glutamatergic (GO:0035249)2.55384708
87cochlea development (GO:0090102)2.53918840
88mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.53794273
89chondrocyte development (GO:0002063)2.53111449
90activation of protein kinase A activity (GO:0034199)2.52394203
91establishment or maintenance of monopolar cell polarity (GO:0061339)2.51822908
92establishment of monopolar cell polarity (GO:0061162)2.51822908
93cochlea morphogenesis (GO:0090103)2.51171800
94spinal cord development (GO:0021510)2.51094328
95regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.51080976
96pre-miRNA processing (GO:0031054)2.50793287
97dorsal/ventral axis specification (GO:0009950)2.49597916
98cerebellar Purkinje cell layer development (GO:0021680)2.49541169
99negative regulation of axon guidance (GO:1902668)2.48345889
100establishment of apical/basal cell polarity (GO:0035089)2.48211993
101regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.47052316
102retinal ganglion cell axon guidance (GO:0031290)2.46955471
103bone trabecula formation (GO:0060346)2.46906660
104* homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.46067169
105neuron projection extension (GO:1990138)2.45260762
106branching involved in salivary gland morphogenesis (GO:0060445)2.44931013
107regulation of synaptic vesicle transport (GO:1902803)2.44576644
108heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.44216731
109convergent extension (GO:0060026)2.43924127
110protein heterotrimerization (GO:0070208)2.43468439
111ephrin receptor signaling pathway (GO:0048013)2.43388847
112polarized epithelial cell differentiation (GO:0030859)2.43289192
113limb bud formation (GO:0060174)2.42139473
114nucleobase catabolic process (GO:0046113)2.41998662
115apical protein localization (GO:0045176)2.41647954
116NLS-bearing protein import into nucleus (GO:0006607)2.39604710
117positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.39407386
118synapse assembly (GO:0007416)2.39065919
119synapse organization (GO:0050808)2.38504602
120cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.38190820
121response to auditory stimulus (GO:0010996)2.38054066
122G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.37945287
123regulation of growth hormone secretion (GO:0060123)2.37886883
124Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.37879695
125positive regulation of dendrite morphogenesis (GO:0050775)2.37490951
126myelination in peripheral nervous system (GO:0022011)2.36819019
127peripheral nervous system axon ensheathment (GO:0032292)2.36819019
128gastrulation with mouth forming second (GO:0001702)2.36411104
129myoblast fusion (GO:0007520)2.35792456
130craniofacial suture morphogenesis (GO:0097094)2.35338386
131protein retention in ER lumen (GO:0006621)2.35160488
132membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.34690862
133behavioral defense response (GO:0002209)2.34678161
134behavioral fear response (GO:0001662)2.34678161
135neuron-neuron synaptic transmission (GO:0007270)2.34459014
136mesenchymal to epithelial transition (GO:0060231)2.34191294
137neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.33898069
138neuron projection morphogenesis (GO:0048812)2.33320464
139presynaptic membrane assembly (GO:0097105)2.33035612
140synaptic vesicle endocytosis (GO:0048488)2.32666886
141heparan sulfate proteoglycan metabolic process (GO:0030201)2.31150421
142glial cell proliferation (GO:0014009)2.31078588
143neuronal ion channel clustering (GO:0045161)2.30958749
144regulation of establishment of planar polarity (GO:0090175)2.30880143
145cytoskeletal anchoring at plasma membrane (GO:0007016)2.30830204
146chondrocyte proliferation (GO:0035988)2.30275376
147generation of neurons (GO:0048699)2.30166517
148endodermal cell differentiation (GO:0035987)2.29921554
149regulation of cell fate specification (GO:0042659)2.29224979
150mating behavior (GO:0007617)2.27481558
151hemidesmosome assembly (GO:0031581)2.26938281
152embryonic retina morphogenesis in camera-type eye (GO:0060059)2.26619266
153* camera-type eye morphogenesis (GO:0048593)2.26282877
154maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.25316226
155lens morphogenesis in camera-type eye (GO:0002089)2.25014357
156outer ear morphogenesis (GO:0042473)2.24377071
157forebrain development (GO:0030900)2.21673193
158embryonic body morphogenesis (GO:0010172)2.19193390
159developmental cell growth (GO:0048588)2.18957532
160artery development (GO:0060840)2.17846149
161neural tube development (GO:0021915)2.17787484
162positive regulation of synapse assembly (GO:0051965)2.17178950
163regulation of NFAT protein import into nucleus (GO:0051532)2.16589999
164kidney mesenchyme development (GO:0072074)2.16492049
165mesenchymal-epithelial cell signaling (GO:0060638)2.14818584
166negative regulation of cartilage development (GO:0061037)2.13636941

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.74253288
2ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.85191503
3GBX2_23144817_ChIP-Seq_PC3_Human2.83731865
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.82851252
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.69237243
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.66105666
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.59589481
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.59589481
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.58351633
10SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.53796279
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.43116109
12EED_16625203_ChIP-ChIP_MESCs_Mouse2.41613069
13RBPJ_22232070_ChIP-Seq_NCS_Mouse2.35810611
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.34400444
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.26245500
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.16214163
17RNF2_27304074_Chip-Seq_ESCs_Mouse2.15590073
18NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.06807513
19DROSHA_22980978_ChIP-Seq_HELA_Human2.03750561
20MTF2_20144788_ChIP-Seq_MESCs_Mouse2.03027154
21NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.96755239
22EZH2_27294783_Chip-Seq_ESCs_Mouse1.94303134
23SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.91266193
24SUZ12_27294783_Chip-Seq_ESCs_Mouse1.81811696
25AR_21572438_ChIP-Seq_LNCaP_Human1.76103809
26RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.74076471
27EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.73221499
28CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.72705187
29REST_21632747_ChIP-Seq_MESCs_Mouse1.72035791
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.69998770
31TP63_17297297_ChIP-ChIP_HaCaT_Human1.67975243
32POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.67906881
33RARB_27405468_Chip-Seq_BRAIN_Mouse1.67143385
34WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.66094407
35POU5F1_16153702_ChIP-ChIP_HESCs_Human1.65011308
36PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.65009387
37FOXM1_23109430_ChIP-Seq_U2OS_Human1.63859514
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.63105739
39ZNF274_21170338_ChIP-Seq_K562_Hela1.54505749
40RING1B_27294783_Chip-Seq_NPCs_Mouse1.52442707
41* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.51952163
42CBX2_27304074_Chip-Seq_ESCs_Mouse1.51039908
43SALL1_21062744_ChIP-ChIP_HESCs_Human1.51026129
44TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.50499759
45ZFP281_18757296_ChIP-ChIP_E14_Mouse1.46579577
46SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.46326566
47ERG_21242973_ChIP-ChIP_JURKAT_Human1.45528102
48RING1B_27294783_Chip-Seq_ESCs_Mouse1.45412922
49CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.45104075
50ZNF217_24962896_ChIP-Seq_MCF-7_Human1.41541575
51TBX3_20139965_ChIP-Seq_MESCs_Mouse1.41191737
52SMAD4_21799915_ChIP-Seq_A2780_Human1.41073270
53SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40803182
54EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.40342958
55TBX3_20139965_ChIP-Seq_ESCs_Mouse1.39933023
56CTBP1_25329375_ChIP-Seq_LNCAP_Human1.38545166
57HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.37471516
58PIAS1_25552417_ChIP-Seq_VCAP_Human1.36527753
59AR_19668381_ChIP-Seq_PC3_Human1.35520384
60WT1_25993318_ChIP-Seq_PODOCYTE_Human1.35098720
61PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.34212902
62ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.34095752
63SOX2_16153702_ChIP-ChIP_HESCs_Human1.31864808
64SMAD3_21741376_ChIP-Seq_EPCs_Human1.31726655
65STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.31248446
66REST_18959480_ChIP-ChIP_MESCs_Mouse1.31139082
67ISL1_27105846_Chip-Seq_CPCs_Mouse1.29896994
68ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.29703646
69DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.29097901
70SOX2_21211035_ChIP-Seq_LN229_Gbm1.28548324
71ZFP281_27345836_Chip-Seq_ESCs_Mouse1.28439187
72TP53_20018659_ChIP-ChIP_R1E_Mouse1.27946657
73YAP1_20516196_ChIP-Seq_MESCs_Mouse1.27946467
74AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.26683972
75KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.25480283
76P300_19829295_ChIP-Seq_ESCs_Human1.24776980
77ARNT_22903824_ChIP-Seq_MCF-7_Human1.23947025
78SOX9_26525672_Chip-Seq_HEART_Mouse1.23788122
79SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.21668561
80TP63_19390658_ChIP-ChIP_HaCaT_Human1.21618541
81HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.20678558
82NR3C1_23031785_ChIP-Seq_PC12_Mouse1.19840763
83AHR_22903824_ChIP-Seq_MCF-7_Human1.19738833
84POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.18189419
85SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.17150289
86TP53_16413492_ChIP-PET_HCT116_Human1.16852467
87GATA1_26923725_Chip-Seq_HPCs_Mouse1.16769453
88STAT3_23295773_ChIP-Seq_U87_Human1.16352706
89FUS_26573619_Chip-Seq_HEK293_Human1.16324041
90NR3C1_21868756_ChIP-Seq_MCF10A_Human1.14890073
91TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13647398
92OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12656334
93KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.12568021
94CDX2_19796622_ChIP-Seq_MESCs_Mouse1.11616413
95TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11405809
96BMI1_23680149_ChIP-Seq_NPCS_Mouse1.10978464
97TP53_18474530_ChIP-ChIP_U2OS_Human1.10135204
98WT1_19549856_ChIP-ChIP_CCG9911_Human1.09189452
99RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.08413608
100NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.08318522
101KDM2B_26808549_Chip-Seq_K562_Human1.07930270
102POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.07893763
103TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07893763
104AR_25329375_ChIP-Seq_VCAP_Human1.07510716
105ZFP57_27257070_Chip-Seq_ESCs_Mouse1.06783274
106SMAD4_21741376_ChIP-Seq_HESCs_Human1.06678972
107TCF3_18692474_ChIP-Seq_MESCs_Mouse1.06514200
108SOX2_18555785_ChIP-Seq_MESCs_Mouse1.06125706
109MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.05958074
110NANOG_16153702_ChIP-ChIP_HESCs_Human1.05309717
111ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.04337420
112TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.03220528
113TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.02858535
114TCF3_18692474_ChIP-Seq_MEFs_Mouse1.02460617
115TAF15_26573619_Chip-Seq_HEK293_Human1.02413506
116EP300_21415370_ChIP-Seq_HL-1_Mouse1.01999143
117TRIM28_21343339_ChIP-Seq_HEK293_Human1.00705821
118SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00145933
119TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.00141799
120TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00068711
121TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.99306113
122FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.98733206
123OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.97624996
124RNF2_27304074_Chip-Seq_NSC_Mouse0.97421914
125IGF1R_20145208_ChIP-Seq_DFB_Human0.96931527
126SMAD3_21741376_ChIP-Seq_ESCs_Human0.96123307
127KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.95480219
128KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.95480219
129KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.95480219

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.11710177
2MP0003122_maternal_imprinting2.95094895
3MP0004270_analgesia2.63236679
4MP0003635_abnormal_synaptic_transmissio2.48595655
5MP0009780_abnormal_chondrocyte_physiolo2.34258818
6MP0003880_abnormal_central_pattern2.24351770
7MP0000778_abnormal_nervous_system2.17060616
8MP0010030_abnormal_orbit_morphology2.15844756
9MP0003283_abnormal_digestive_organ2.11131913
10MP0002063_abnormal_learning/memory/cond2.10765477
11MP0004858_abnormal_nervous_system2.09327489
12MP0009053_abnormal_anal_canal2.04835778
13MP0005257_abnormal_intraocular_pressure2.00694510
14MP0003123_paternal_imprinting1.92709525
15MP0003385_abnormal_body_wall1.92542542
16MP0000534_abnormal_ureter_morphology1.91342992
17MP0003942_abnormal_urinary_system1.90575328
18MP0000569_abnormal_digit_pigmentation1.88894115
19MP0000566_synostosis1.84161765
20MP0005503_abnormal_tendon_morphology1.83506393
21MP0000537_abnormal_urethra_morphology1.81895949
22MP0002697_abnormal_eye_size1.79318314
23MP0003121_genomic_imprinting1.74051714
24MP0000579_abnormal_nail_morphology1.71919018
25MP0005423_abnormal_somatic_nervous1.70297493
26MP0009745_abnormal_behavioral_response1.67112485
27MP0005248_abnormal_Harderian_gland1.65266322
28MP0005187_abnormal_penis_morphology1.59668507
29MP0000049_abnormal_middle_ear1.58069290
30MP0004233_abnormal_muscle_weight1.57735419
31MP0002734_abnormal_mechanical_nocicepti1.56972837
32MP0002572_abnormal_emotion/affect_behav1.54738510
33MP0002184_abnormal_innervation1.54540920
34MP0001299_abnormal_eye_distance/1.52632447
35MP0005275_abnormal_skin_tensile1.52573638
36MP0009250_abnormal_appendicular_skeleto1.49446068
37MP0001486_abnormal_startle_reflex1.49201242
38MP0003705_abnormal_hypodermis_morpholog1.47839858
39MP0003755_abnormal_palate_morphology1.47598119
40MP0000955_abnormal_spinal_cord1.46532267
41MP0003787_abnormal_imprinting1.44562439
42MP0003119_abnormal_digestive_system1.42469407
43MP0002249_abnormal_larynx_morphology1.41355073
44MP0002064_seizures1.40722752
45MP0003937_abnormal_limbs/digits/tail_de1.36373135
46MP0004885_abnormal_endolymph1.35731554
47MP0001968_abnormal_touch/_nociception1.34746326
48MP0001346_abnormal_lacrimal_gland1.34512943
49MP0002233_abnormal_nose_morphology1.30562502
50MP0004811_abnormal_neuron_physiology1.28596956
51MP0003935_abnormal_craniofacial_develop1.27386317
52MP0005623_abnormal_meninges_morphology1.26778622
53MP0002092_abnormal_eye_morphology1.26267470
54MP0006292_abnormal_olfactory_placode1.25848002
55MP0002557_abnormal_social/conspecific_i1.24471883
56MP0000428_abnormal_craniofacial_morphol1.22278229
57MP0009046_muscle_twitch1.21746866
58MP0008438_abnormal_cutaneous_collagen1.20016610
59MP0001286_abnormal_eye_development1.19874452
60MP0003861_abnormal_nervous_system1.19069307
61MP0002116_abnormal_craniofacial_bone1.19026634
62MP0002653_abnormal_ependyma_morphology1.18620530
63MP0003115_abnormal_respiratory_system1.18507308
64MP0004272_abnormal_basement_membrane1.15848915
65MP0002152_abnormal_brain_morphology1.14839885
66MP0002882_abnormal_neuron_morphology1.14474098
67MP0002932_abnormal_joint_morphology1.14395101
68MP0002234_abnormal_pharynx_morphology1.13739551
69MP0000631_abnormal_neuroendocrine_gland1.13122544
70MP0002084_abnormal_developmental_patter1.11873389
71MP0009672_abnormal_birth_weight1.10306154
72MP0004133_heterotaxia1.09564405
73MP0005394_taste/olfaction_phenotype1.08034535
74MP0005499_abnormal_olfactory_system1.08034535
75MP0002909_abnormal_adrenal_gland1.08010796
76MP0001849_ear_inflammation1.07845259
77MP0002938_white_spotting1.06699215
78MP0005377_hearing/vestibular/ear_phenot1.06576418
79MP0003878_abnormal_ear_physiology1.06576418
80MP0002272_abnormal_nervous_system1.05346398
81MP0001958_emphysema1.05200373
82MP0002085_abnormal_embryonic_tissue1.04542134
83MP0000462_abnormal_digestive_system1.04503184
84MP0003890_abnormal_embryonic-extraembry1.03876299
85MP0009384_cardiac_valve_regurgitation1.03238415
86MP0002735_abnormal_chemical_nociception1.00626157
87MP0001177_atelectasis0.99369065
88MP0002067_abnormal_sensory_capabilities0.99262018
89MP0002733_abnormal_thermal_nociception0.99008602
90MP0003938_abnormal_ear_development0.97308188
91MP0002111_abnormal_tail_morphology0.97270904
92MP0002254_reproductive_system_inflammat0.96978776
93MP0003566_abnormal_cell_adhesion0.96786036
94MP0008789_abnormal_olfactory_epithelium0.96616646
95MP0005197_abnormal_uvea_morphology0.96164073
96MP0002822_catalepsy0.96055603
97MP0005171_absent_coat_pigmentation0.95686070
98MP0002108_abnormal_muscle_morphology0.92874941
99MP0004145_abnormal_muscle_electrophysio0.92822686
100MP0008932_abnormal_embryonic_tissue0.92810445
101MP0003136_yellow_coat_color0.92614067
102MP0002896_abnormal_bone_mineralization0.92395139
103MP0001529_abnormal_vocalization0.91764265
104MP0001440_abnormal_grooming_behavior0.89468480
105MP0005367_renal/urinary_system_phenotyp0.89305908
106MP0000516_abnormal_urinary_system0.89305908
107MP0000762_abnormal_tongue_morphology0.89286960
108MP0010368_abnormal_lymphatic_system0.89076991
109MP0002081_perinatal_lethality0.87384007
110MP0005646_abnormal_pituitary_gland0.87238113
111MP0001293_anophthalmia0.87208350
112MP0001984_abnormal_olfaction0.86576831
113MP0001501_abnormal_sleep_pattern0.85988850
114MP0006276_abnormal_autonomic_nervous0.85649283
115MP0003329_amyloid_beta_deposits0.85285964
116MP0005076_abnormal_cell_differentiation0.83203435
117MP0005508_abnormal_skeleton_morphology0.82937058
118MP0002109_abnormal_limb_morphology0.82882079
119MP0004924_abnormal_behavior0.82832895
120MP0005386_behavior/neurological_phenoty0.82832895
121MP0003941_abnormal_skin_development0.82734164
122MP0003315_abnormal_perineum_morphology0.82524366
123MP0009703_decreased_birth_body0.82495741
124MP0002066_abnormal_motor_capabilities/c0.82088797
125MP0000733_abnormal_muscle_development0.80236876
126MP0002751_abnormal_autonomic_nervous0.79952684
127MP0005391_vision/eye_phenotype0.79459013
128MP0002282_abnormal_trachea_morphology0.79365508
129MP0000432_abnormal_head_morphology0.78873763
130MP0005409_darkened_coat_color0.78655547
131MP0001970_abnormal_pain_threshold0.78442056
132MP0002114_abnormal_axial_skeleton0.78154860
133MP0004197_abnormal_fetal_growth/weight/0.76989861

Predicted human phenotypes

RankGene SetZ-score
1Short 4th metacarpal (HP:0010044)4.03447042
2Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)4.03447042
3Premature rupture of membranes (HP:0001788)3.95141698
4Hepatoblastoma (HP:0002884)3.46534400
5Abnormality of the 4th metacarpal (HP:0010012)3.24156593
6Atrophic scars (HP:0001075)3.14450110
7Shallow orbits (HP:0000586)3.13041725
8Abnormality of dentin (HP:0010299)2.91926930
9Neonatal short-limb short stature (HP:0008921)2.88976719
10Renal duplication (HP:0000075)2.77208681
11Myokymia (HP:0002411)2.76228993
12Focal motor seizures (HP:0011153)2.72259392
13Cutaneous finger syndactyly (HP:0010554)2.69021521
14Focal seizures (HP:0007359)2.58735582
15High anterior hairline (HP:0009890)2.49065233
16Termporal pattern (HP:0011008)2.46648379
17Insidious onset (HP:0003587)2.46648379
18Soft skin (HP:0000977)2.40965381
19Epileptic encephalopathy (HP:0200134)2.37153956
20Cutaneous syndactyly (HP:0012725)2.37081716
21Turricephaly (HP:0000262)2.36487826
22Renovascular hypertension (HP:0100817)2.30415214
23Midline defect of the nose (HP:0004122)2.28800206
24Action tremor (HP:0002345)2.27479766
25Protrusio acetabuli (HP:0003179)2.27293667
26Vitreoretinal degeneration (HP:0000655)2.25584835
27Microglossia (HP:0000171)2.25425029
28Ulnar bowing (HP:0003031)2.25367048
29Ankle contracture (HP:0006466)2.24704843
30Morphological abnormality of the middle ear (HP:0008609)2.22342992
31Myelomeningocele (HP:0002475)2.19731235
32Megalencephaly (HP:0001355)2.12893219
33Ankyloglossia (HP:0010296)2.12397838
34Buphthalmos (HP:0000557)2.11475380
35Vascular tortuosity (HP:0004948)2.10904338
36Excessive salivation (HP:0003781)2.08555327
37Drooling (HP:0002307)2.08555327
38Genetic anticipation (HP:0003743)2.07810818
39Aortic dissection (HP:0002647)2.07115739
40Vertebral arch anomaly (HP:0008438)2.06797521
41Arterial tortuosity (HP:0005116)2.06450373
42Coronal craniosynostosis (HP:0004440)2.02272437
43Abnormality of the lower motor neuron (HP:0002366)2.01390113
44Bladder diverticulum (HP:0000015)1.98897588
45Bowel diverticulosis (HP:0005222)1.96359854
46Aqueductal stenosis (HP:0002410)1.95123294
47Insomnia (HP:0100785)1.95075788
48Macroorchidism (HP:0000053)1.93816991
49Abnormality of the ischium (HP:0003174)1.93554303
50Fragile skin (HP:0001030)1.91293043
51Overgrowth (HP:0001548)1.90651653
52Pointed chin (HP:0000307)1.88393959
53Elfin facies (HP:0004428)1.86814921
54Septo-optic dysplasia (HP:0100842)1.84991185
55Impaired vibration sensation in the lower limbs (HP:0002166)1.84989161
56Broad thumb (HP:0011304)1.84780144
57Hyperacusis (HP:0010780)1.82956824
58Visual hallucinations (HP:0002367)1.82791365
59Lymphangioma (HP:0100764)1.81718204
60Abnormality of the distal phalanx of the thumb (HP:0009617)1.81224280
61Infantile muscular hypotonia (HP:0008947)1.80572696
62Sacral dimple (HP:0000960)1.79264998
63Urinary bladder sphincter dysfunction (HP:0002839)1.79083559
64Bronchomalacia (HP:0002780)1.79008664
65Epileptiform EEG discharges (HP:0011182)1.78147966
66Cortical dysplasia (HP:0002539)1.78067174
67Mitral valve prolapse (HP:0001634)1.76690654
68Aplasia involving bones of the upper limbs (HP:0009823)1.76374344
69Aplasia of the phalanges of the hand (HP:0009802)1.76374344
70Aplasia involving bones of the extremities (HP:0009825)1.76374344
71Cerebral inclusion bodies (HP:0100314)1.76099063
72Deviation of the hallux (HP:0010051)1.75551232
73Broad metatarsal (HP:0001783)1.75467383
74Progressive cerebellar ataxia (HP:0002073)1.75174085
75Abnormality of the phalanges of the hallux (HP:0010057)1.74748606
76EEG with generalized epileptiform discharges (HP:0011198)1.74430929
77Partial duplication of the phalanx of hand (HP:0009999)1.73192895
78Abnormality of the calcaneus (HP:0008364)1.71053942
79Absence seizures (HP:0002121)1.70993539
80Arnold-Chiari malformation (HP:0002308)1.69787853
81Omphalocele (HP:0001539)1.69307895
82Wide anterior fontanel (HP:0000260)1.69254177
83Abnormality of the diencephalon (HP:0010662)1.68913031
84Hypsarrhythmia (HP:0002521)1.68842873
85Narrow nasal bridge (HP:0000446)1.68588624
86Broad-based gait (HP:0002136)1.68260228
87Partial duplication of thumb phalanx (HP:0009944)1.67677670
88Preaxial foot polydactyly (HP:0001841)1.67668987
89Mild short stature (HP:0003502)1.67492262
90Flat cornea (HP:0007720)1.67237092
91Trigonocephaly (HP:0000243)1.67149296
92Hyperextensible skin (HP:0000974)1.67142864
93Bifid tongue (HP:0010297)1.67036024
94Absent eyebrow (HP:0002223)1.67011234
95Hallux valgus (HP:0001822)1.66465224
96Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.66416141
97Obsessive-compulsive behavior (HP:0000722)1.65996630
98Anophthalmia (HP:0000528)1.65793438
99Papillary thyroid carcinoma (HP:0002895)1.65514758
100Choanal stenosis (HP:0000452)1.65052975
101Calcaneovalgus deformity (HP:0001848)1.65037042
102Asymmetry of the thorax (HP:0001555)1.64754300
103Renal hypoplasia (HP:0000089)1.64607813
104Breech presentation (HP:0001623)1.64246899
105Astrocytoma (HP:0009592)1.63586434
106Abnormality of the astrocytes (HP:0100707)1.63586434
107Amblyopia (HP:0000646)1.63552004
108Overriding aorta (HP:0002623)1.63375598
109Thin ribs (HP:0000883)1.62876872
110Abnormality of the corticospinal tract (HP:0002492)1.61899863
111Hyperventilation (HP:0002883)1.61889241
112Hypoplastic ischia (HP:0003175)1.61885352
113Ankle clonus (HP:0011448)1.61328856
114Neoplasm of the heart (HP:0100544)1.61299506
115Broad long bones (HP:0005622)1.59505657
116Narrow palate (HP:0000189)1.58279960
117Generalized tonic-clonic seizures (HP:0002069)1.57684106
118Broad finger (HP:0001500)1.56471700
119Torticollis (HP:0000473)1.55680286
120Atonic seizures (HP:0010819)1.55354712
121Aplasia/Hypoplasia of metatarsal bones (HP:0001964)1.55246217
122Hypoplasia of the maxilla (HP:0000327)1.54811631
123Abnormality of the pubic bones (HP:0003172)1.54809265
124Increased nuchal translucency (HP:0010880)1.54506033
125Relative macrocephaly (HP:0004482)1.54029805
126Missing ribs (HP:0000921)1.53959891
127Hypoventilation (HP:0002791)1.53867414
128Vertebral clefting (HP:0008428)1.53419498
129Abnormality of oral frenula (HP:0000190)1.53224223
130Absent frontal sinuses (HP:0002688)1.52663478
131Cervical subluxation (HP:0003308)1.52477260
132Esophageal atresia (HP:0002032)1.52319289
133Broad phalanges of the hand (HP:0009768)1.51997286
134Fibular hypoplasia (HP:0003038)1.51563505
135Increased number of teeth (HP:0011069)1.51501535
136Wormian bones (HP:0002645)1.51074665
137Pterygium (HP:0001059)1.51040553
138Agitation (HP:0000713)1.50668462
139Genu recurvatum (HP:0002816)1.50545658
140Dilatation of the ascending aorta (HP:0005111)1.49545649
141Broad phalanx (HP:0006009)1.49192215
142Bilateral microphthalmos (HP:0007633)1.48949594
143Natal tooth (HP:0000695)1.48105246
144Deformed tarsal bones (HP:0008119)1.47211650
145Mitral regurgitation (HP:0001653)1.46564518
146Tracheomalacia (HP:0002779)1.46008205
147Congenital glaucoma (HP:0001087)1.44980350
148Abnormality of the parietal bone (HP:0002696)1.44446528
149Synostosis of carpal bones (HP:0005048)1.44164167
150Limited hip movement (HP:0008800)1.43985414
151Abnormality of the antihelix (HP:0009738)1.43794099
152Biconcave vertebral bodies (HP:0004586)1.43379109
153Abnormality of the aortic arch (HP:0012303)1.43141851

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.33846574
2EPHA43.48786476
3NTRK33.18278430
4MAP3K92.66118525
5MAP3K42.41995704
6LATS22.41496718
7MINK12.24863404
8LATS12.24339639
9PRKD32.18898590
10NTRK12.14820078
11NTRK22.09502969
12KSR12.08341190
13DDR21.95959385
14PAK61.84520105
15STK38L1.81278015
16DAPK21.72158984
17EPHB21.70576501
18PDGFRA1.60461257
19SIK11.46562548
20ERBB31.46433898
21MAPK131.32839475
22MAP2K41.32593223
23BRD41.31997377
24RIPK11.28099279
25PHKG11.27924651
26PHKG21.27924651
27SIK21.26371808
28MAP2K71.26144957
29CAMK1G1.25902731
30PLK21.23464118
31CAMKK11.22411736
32CDC71.21624735
33PAK21.21547389
34FGFR21.20754661
35KSR21.19929002
36TYRO31.19674036
37CASK1.13140063
38PNCK1.10727417
39CDK51.08514823
40TTN1.07072069
41PAK31.06882814
42MET1.05155655
43EPHA31.02297585
44PRKCG1.02028742
45NEK21.01820011
46MKNK11.00926930
47STK380.99904694
48ERBB20.98716154
49CSNK1G20.98482739
50ICK0.98251375
51TTK0.96096523
52FGFR10.95786464
53SRPK10.95264063
54TRIB30.93911399
55RET0.92383618
56ROCK20.90791565
57MKNK20.89998238
58STK30.88559399
59CDK190.85858133
60MOS0.85357579
61DYRK20.82790406
62CDK180.82734986
63TAF10.81265014
64PTK20.80883850
65CDK150.80741021
66CDK140.80041783
67MARK20.77739944
68DYRK30.74119314
69CAMK1D0.73867738
70FER0.73842486
71CDC42BPA0.73216497
72MAP3K20.72895515
73DAPK10.72872545
74PASK0.71416203
75CSNK1A1L0.71086583
76CDK120.70218549
77SGK20.70029010
78SGK30.69988380
79TSSK60.69926923
80LIMK10.69197364
81ALK0.68629208
82MAP3K100.68436915
83DYRK1A0.68213344
84CDK11A0.67719627
85SCYL20.67158800
86MTOR0.66613453
87UHMK10.66565820
88NEK10.66476083
89PLK30.65922065
90DMPK0.65555519
91SGK4940.65389569
92SGK2230.65389569
93NEK90.65034633
94TNIK0.64598855
95WEE10.61938699
96PRKCH0.61914763
97PAK40.61843666
98PRKCZ0.60947326
99CAMK2A0.59956296
100PLK10.59232216
101AKT30.58192155
102SGK10.57595455
103RPS6KA20.56083424
104MAPK100.55659782
105PRPF4B0.55113170
106WNK30.55069217
107STK110.54228759
108EEF2K0.54077967
109ROCK10.53812695
110BCR0.53404034
111TAOK10.52692369
112PDGFRB0.52470382
113RPS6KA30.51625415
114LMTK20.51588915
115FLT30.50845890
116PKN20.50635180
117RPS6KA40.50183671
118INSRR0.49364181
119CHEK20.49012474
120CSNK1E0.48734742
121PTK60.46431168
122PRKDC0.45810260
123FYN0.43800689
124AURKB0.43581827
125CDK70.43544609
126CSNK1G10.43250425
127CSNK1G30.42595111
128CDK10.42362545
129CAMK40.42342795
130TRIM280.41934095
131GSK3B0.41933231
132MAPK80.41868131
133PLK40.41682972
134CSNK1D0.41669244
135ERBB40.41478306
136ATM0.41446342
137PRKCE0.39866793

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.58081209
2Circadian entrainment_Homo sapiens_hsa047132.25451671
3GABAergic synapse_Homo sapiens_hsa047272.07516714
4Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.07389280
5Long-term potentiation_Homo sapiens_hsa047202.01641022
6Axon guidance_Homo sapiens_hsa043601.97729850
7Amphetamine addiction_Homo sapiens_hsa050311.95719271
8Nitrogen metabolism_Homo sapiens_hsa009101.94931598
9Glutamatergic synapse_Homo sapiens_hsa047241.92481370
10Olfactory transduction_Homo sapiens_hsa047401.87663972
11Synaptic vesicle cycle_Homo sapiens_hsa047211.83600679
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.83555359
13Dopaminergic synapse_Homo sapiens_hsa047281.83000202
14Insulin secretion_Homo sapiens_hsa049111.80500351
15Basal cell carcinoma_Homo sapiens_hsa052171.78957651
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.78336488
17Morphine addiction_Homo sapiens_hsa050321.76551323
18Cocaine addiction_Homo sapiens_hsa050301.64998828
19Hedgehog signaling pathway_Homo sapiens_hsa043401.62643772
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.62510866
21Cholinergic synapse_Homo sapiens_hsa047251.60540304
22Melanogenesis_Homo sapiens_hsa049161.57550834
23Salivary secretion_Homo sapiens_hsa049701.56264817
24Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.49750613
25Renin secretion_Homo sapiens_hsa049241.47539340
26Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.46242269
27Gap junction_Homo sapiens_hsa045401.45901139
28Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.45763845
29Hippo signaling pathway_Homo sapiens_hsa043901.41993494
30Steroid biosynthesis_Homo sapiens_hsa001001.36046866
31Glioma_Homo sapiens_hsa052141.34873115
32Type II diabetes mellitus_Homo sapiens_hsa049301.33918983
33Notch signaling pathway_Homo sapiens_hsa043301.31570883
34Gastric acid secretion_Homo sapiens_hsa049711.30998771
35Estrogen signaling pathway_Homo sapiens_hsa049151.30958783
36Wnt signaling pathway_Homo sapiens_hsa043101.30794925
37Long-term depression_Homo sapiens_hsa047301.29024023
38Oxytocin signaling pathway_Homo sapiens_hsa049211.25419934
39Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.25417924
40GnRH signaling pathway_Homo sapiens_hsa049121.17233483
41Thyroid cancer_Homo sapiens_hsa052161.14758126
42Taste transduction_Homo sapiens_hsa047421.14420899
43Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.12411303
44Endometrial cancer_Homo sapiens_hsa052131.11889375
45Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.09867649
46Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.09792567
47Calcium signaling pathway_Homo sapiens_hsa040201.08627335
48cAMP signaling pathway_Homo sapiens_hsa040241.07753432
49ErbB signaling pathway_Homo sapiens_hsa040121.07242809
50Dilated cardiomyopathy_Homo sapiens_hsa054141.06024279
51Serotonergic synapse_Homo sapiens_hsa047261.04113934
52Cell cycle_Homo sapiens_hsa041101.02567374
53cGMP-PKG signaling pathway_Homo sapiens_hsa040221.02423861
54Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.01106157
55Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.98372124
56Oocyte meiosis_Homo sapiens_hsa041140.98213607
57Pathways in cancer_Homo sapiens_hsa052000.97855423
58Dorso-ventral axis formation_Homo sapiens_hsa043200.96614791
59Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.94977737
60mTOR signaling pathway_Homo sapiens_hsa041500.94464497
61Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.93797451
62Small cell lung cancer_Homo sapiens_hsa052220.93576163
63Thyroid hormone signaling pathway_Homo sapiens_hsa049190.92667614
64Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.91390517
65Bile secretion_Homo sapiens_hsa049760.90848514
66Colorectal cancer_Homo sapiens_hsa052100.89046305
67Glucagon signaling pathway_Homo sapiens_hsa049220.87736771
68Adherens junction_Homo sapiens_hsa045200.87264979
69Regulation of actin cytoskeleton_Homo sapiens_hsa048100.87108129
70PI3K-Akt signaling pathway_Homo sapiens_hsa041510.86892652
71Thyroid hormone synthesis_Homo sapiens_hsa049180.84947278
72Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.81652393
73Proteoglycans in cancer_Homo sapiens_hsa052050.80535003
74Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.80149993
75Alcoholism_Homo sapiens_hsa050340.78947210
76mRNA surveillance pathway_Homo sapiens_hsa030150.78229080
77Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.78225775
78Prostate cancer_Homo sapiens_hsa052150.77840988
79Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.77762275
80Rap1 signaling pathway_Homo sapiens_hsa040150.77469919
81Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.77266805
82Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.76387086
83Focal adhesion_Homo sapiens_hsa045100.75722463
84Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.74153148
85Neurotrophin signaling pathway_Homo sapiens_hsa047220.73193854
86Amoebiasis_Homo sapiens_hsa051460.72737974
87Vascular smooth muscle contraction_Homo sapiens_hsa042700.72347767
88Longevity regulating pathway - mammal_Homo sapiens_hsa042110.71621081
89Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.71282898
90Arginine biosynthesis_Homo sapiens_hsa002200.69973333
91Phospholipase D signaling pathway_Homo sapiens_hsa040720.69786138
92Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.67933592
93Central carbon metabolism in cancer_Homo sapiens_hsa052300.67457160
94Insulin signaling pathway_Homo sapiens_hsa049100.66945254
95ECM-receptor interaction_Homo sapiens_hsa045120.65418256
96Renal cell carcinoma_Homo sapiens_hsa052110.65298412
97Tight junction_Homo sapiens_hsa045300.65117118
98Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.64555013
99Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.63371481
100N-Glycan biosynthesis_Homo sapiens_hsa005100.63210338
101MAPK signaling pathway_Homo sapiens_hsa040100.62370942
102TGF-beta signaling pathway_Homo sapiens_hsa043500.62220753
103Lysine degradation_Homo sapiens_hsa003100.61289155
104Non-small cell lung cancer_Homo sapiens_hsa052230.60208523
105Bladder cancer_Homo sapiens_hsa052190.59853799
106RNA transport_Homo sapiens_hsa030130.59352155
107AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.59050205
108Butanoate metabolism_Homo sapiens_hsa006500.58549243
109Choline metabolism in cancer_Homo sapiens_hsa052310.58492699
110MicroRNAs in cancer_Homo sapiens_hsa052060.58168486
111Biosynthesis of amino acids_Homo sapiens_hsa012300.58160767
112Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.57884433
113Phosphatidylinositol signaling system_Homo sapiens_hsa040700.57226622
114Ras signaling pathway_Homo sapiens_hsa040140.57022264
115Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.56622704
116Non-homologous end-joining_Homo sapiens_hsa034500.56095760
117Circadian rhythm_Homo sapiens_hsa047100.55978683
118Phototransduction_Homo sapiens_hsa047440.54567356
119Carbohydrate digestion and absorption_Homo sapiens_hsa049730.54177786
120Melanoma_Homo sapiens_hsa052180.53879017
121Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.52132028
122Cardiac muscle contraction_Homo sapiens_hsa042600.52031229
123Chronic myeloid leukemia_Homo sapiens_hsa052200.51638283
124Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.50795650
125p53 signaling pathway_Homo sapiens_hsa041150.49977168
126Protein digestion and absorption_Homo sapiens_hsa049740.49911823
127Ovarian steroidogenesis_Homo sapiens_hsa049130.48252687
128AMPK signaling pathway_Homo sapiens_hsa041520.48095616
129Insulin resistance_Homo sapiens_hsa049310.46807246
130Fatty acid biosynthesis_Homo sapiens_hsa000610.46289871
131Vibrio cholerae infection_Homo sapiens_hsa051100.43833064

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